pulmonary circulation

Summary

Summary: The circulation of the BLOOD through the LUNGS.

Top Publications

  1. ncbi Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat
    H A Golpon
    Department of Internal Medicine, Philipps University of Marburg, Baldinger Strasse, 35033, Marburg, Germany
    Regul Pept 102:81-6. 2001
  2. ncbi Regulation of the pulmonary circulation in the fetus and newborn
    Yuansheng Gao
    Department of Physiology and Pathophysiology, Peking University, Health Science Center, Beijing, China
    Physiol Rev 90:1291-335. 2010
  3. ncbi The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness
    Dante Penaloza
    Department of Medicine, Faculty of Medicine, University Cayetano Heredia, Lima, Peru
    Circulation 115:1132-46. 2007
  4. pmc Effect of ablated bronchial blood flow on survival rate and pulmonary function after burn and smoke inhalation in sheep
    Atsumori Hamahata
    Department of Plastic and Reconstructive Surgery, Tokyo Women s Medical University, Tokyo, Japan
    Burns 35:802-10. 2009
  5. pmc Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension
    Kendall S Hunter
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Am Heart J 155:166-74. 2008
  6. pmc Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation
    Gregory B Waypa
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Respir Crit Care Med 187:424-32. 2013
  7. ncbi The Fontan circulation: who controls cardiac output?
    Marc Gewillig
    Paediatric and Congenital Cardiology, University Hospitals Leuven, Belgium
    Interact Cardiovasc Thorac Surg 10:428-33. 2010
  8. ncbi Separating the direct effect of hypoxia from the indirect effect of changes in cardiac output on the maximum pressure difference across the tricuspid valve in healthy humans
    George M Balanos
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Pflugers Arch 450:372-80. 2005
  9. pmc Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension
    Shruti Sharma
    Program in Pulmonary Disease, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 294:L46-56. 2008
  10. pmc Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation
    Katherine Howell
    Department of Physiology, Conway Institute of Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College, Dublin, Ireland
    J Physiol 547:133-45. 2003

Detail Information

Publications261 found, 100 shown here

  1. ncbi Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat
    H A Golpon
    Department of Internal Medicine, Philipps University of Marburg, Baldinger Strasse, 35033, Marburg, Germany
    Regul Pept 102:81-6. 2001
    ..In conclusion, GLP-1 and amylin represent two additional peptides which may modulate pulmonary vascular tone...
  2. ncbi Regulation of the pulmonary circulation in the fetus and newborn
    Yuansheng Gao
    Department of Physiology and Pathophysiology, Peking University, Health Science Center, Beijing, China
    Physiol Rev 90:1291-335. 2010
    ..The development of the pulmonary circulation is genetically controlled by an array of mitogenic factors in a temporo-spatial order...
  3. ncbi The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness
    Dante Penaloza
    Department of Medicine, Faculty of Medicine, University Cayetano Heredia, Lima, Peru
    Circulation 115:1132-46. 2007
    ..present study is to review the physiology, pathology, pathogenesis, and clinical features of the heart and pulmonary circulation in healthy highlanders and patients with chronic mountain sickness...
  4. pmc Effect of ablated bronchial blood flow on survival rate and pulmonary function after burn and smoke inhalation in sheep
    Atsumori Hamahata
    Department of Plastic and Reconstructive Surgery, Tokyo Women s Medical University, Tokyo, Japan
    Burns 35:802-10. 2009
    ..Ablated bronchial circulation attenuated these pathophysiological changes...
  5. pmc Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension
    Kendall S Hunter
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Am Heart J 155:166-74. 2008
    ....
  6. pmc Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation
    Gregory B Waypa
    Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Respir Crit Care Med 187:424-32. 2013
    ..Hence, genetic animal models are required to test mechanistic hypotheses...
  7. ncbi The Fontan circulation: who controls cardiac output?
    Marc Gewillig
    Paediatric and Congenital Cardiology, University Hospitals Leuven, Belgium
    Interact Cardiovasc Thorac Surg 10:428-33. 2010
    ..A conceptual model of the determinants of cardiac output in Fontan patients is presented...
  8. ncbi Separating the direct effect of hypoxia from the indirect effect of changes in cardiac output on the maximum pressure difference across the tricuspid valve in healthy humans
    George M Balanos
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Pflugers Arch 450:372-80. 2005
    ..The low sensitivity of DeltaPmax to changes in cardiac output makes it a useful index of hypoxic pulmonary vasoconstriction in healthy humans...
  9. pmc Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension
    Shruti Sharma
    Program in Pulmonary Disease, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 294:L46-56. 2008
    ..Our data suggest that mitochondrial dysfunction may play a role in the development of endothelial dysfunction and pulmonary hypertension and increased pulmonary blood flow...
  10. pmc Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation
    Katherine Howell
    Department of Physiology, Conway Institute of Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College, Dublin, Ireland
    J Physiol 547:133-45. 2003
    ..of chronic hypoxia in all other vascular beds and the demonstration that new vessels can form in the pulmonary circulation when stimulated by chronic infection and lung resection...
  11. ncbi NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs
    N Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 280:L638-45. 2001
    ....
  12. pmc Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine model
    Atsumori Hamahata
    Department of Plastic and Reconstructive Surgery, Tokyo Women s Medical University, 8 1 Kawada cho Shinjuku ku, Tokyo 162 8666, Japan
    Burns 36:1042-9. 2010
    ..We hypothesized that sclerosis of the bronchial artery after insult attenuates smoke/burn-induced acute lung injury...
  13. ncbi Effect of inhaled nitric oxide on pulmonary vascular hyperpermeability in sheep following smoke inhalation
    Perenlei Enkhbaatar
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch at Galveston, 610 Texas Avenue, Galveston, TX 77555 0833, USA
    Burns 31:1013-9. 2005
    ..Nitric oxide inhalation ameliorated the above-mentioned pathological changes. The results suggest that nitric oxide inhalation has potential for beneficial effect in the treatment of patients suffering from smoke inhalation...
  14. ncbi Aortopulmonary collaterals after bidirectional cavopulmonary connection or Fontan completion: quantification with MRI
    Lars Grosse-Wortmann
    The Labatt Family Heart Center and the Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Circ Cardiovasc Imaging 2:219-25. 2009
    ..We aimed to quantify APC flow after bidirectional cavopulmonary connections and Fontan completions, using phase-contrast MRI, and to identify risk factors for the development of APCs...
  15. ncbi Dual-energy CT for assessment of the severity of acute pulmonary embolism: pulmonary perfusion defect score compared with CT angiographic obstruction score and right ventricular/left ventricular diameter ratio
    Eun Jin Chae
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    AJR Am J Roentgenol 194:604-10. 2010
    ..The purpose of this study was to prospectively evaluate the usefulness of scoring perfusion defects on perfusion images at dual-energy CT for assessment of the severity of pulmonary embolism...
  16. pmc Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress
    Peter E Oishi
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 295:L756-66. 2008
    ..05). We conclude that increased pulmonary blood flow results in progressive impairment of basal and agonist-induced NOS function, in part secondary to oxidative stress that decreases bioavailable NO...
  17. ncbi Contrast echocardiography for pulmonary blood volume quantification
    Massimo Mischi
    Eindhoven University of Technology, Eindhoven, The Netherlands
    IEEE Trans Ultrason Ferroelectr Freq Control 51:1137-47. 2004
    ..The results show very accurate volume measurements. The volume estimate determination coefficient is greater than 0.999 for both model fits. A preliminary study in patients shows promising results...
  18. pmc Involvement of ceramide in cell death responses in the pulmonary circulation
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    Proc Am Thorac Soc 8:492-6. 2011
    ....
  19. pmc Prolonged hypoxia augments L-citrulline transport by system A in the newborn piglet pulmonary circulation
    Candice D Fike
    Department of Pediatrics, University School of Medicine, Vanderbilt University Medical Center, 2215 B Garland Ave, Nashville, TN 37232 0656, USA
    Cardiovasc Res 95:375-84. 2012
    ....
  20. ncbi Lung capillary changes in hepatic cirrhosis in rats
    D E Schraufnagel
    Department of Medicine, University of Illinois at Chicago 60612, USA
    Am J Physiol 272:L139-47. 1997
    ..In the ligated animals, evidence for enhancement of the bronchial to pulmonary circulation was found: cast vasa vasorum of the pulmonary arteries and cast bronchial veins emptying into pulmonary ..
  21. ncbi Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms
    N Sommer
    University of Giessen Lung Center, Medical Clinic II V, Justus Liebig University Giessen, Giessen, Germany
    Eur Respir J 32:1639-51. 2008
    ....
  22. ncbi Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography
    Daryl O Schwenke
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    J Appl Physiol 102:787-93. 2007
    Structural changes of the pulmonary circulation during the pathogenesis of pulmonary arterial hypertension remain to be fully elucidated...
  23. ncbi Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambs
    Girija G Konduri
    Department of Pediatrics and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 283:H1600-8. 2002
    ..An increase in oxidative phosphorylation and ATP release during oxygen exposure may contribute to birth-related pulmonary vasodilation in fetal lambs...
  24. ncbi Usefulness of a new Doppler index for assessing both ventricular functions and pulmonary circulation in newborn piglet with hypoxic pulmonary hypertension
    Takahiro Sugiura
    Department of Pediatrics, Nagoya City University Medical School and Department of Pediatrics, Nagoya City Johoku Hospital, Japan
    Pediatr Res 53:927-32. 2003
    ..Serial evaluation of pulmonary circulation and cardiac function is important, but available imaging techniques have been limited...
  25. ncbi Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation
    K A Fagan
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol 277:L472-8. 1999
    ..3 +/- 0.7 mmHg). We conclude that in the normal murine pulmonary circulation 1) nNOS does not modulate tone, 2) eNOS-derived nitric oxide is the principle mediator of endothelium-..
  26. ncbi Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow
    Shruti Sharma
    Vascular Biology Center, Medical College of Georgia, CB3210B, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 293:L960-71. 2007
    ..An increased understanding of these alterations may have important therapeutic implications for the treatment of pulmonary hypertension secondary to increased pulmonary blood flow...
  27. pmc The interdependent contributions of gravitational and structural features to perfusion distribution in a multiscale model of the pulmonary circulation
    A R Clark
    Auckland Bioengineering Institute, Univ of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    J Appl Physiol (1985) 110:943-55. 2011
    ..presence of tissue deformation, we have developed an anatomically structured computational model of the pulmonary circulation (arteries, capillaries, veins), coupled to a continuum model of tissue deformation, and including scale-..
  28. ncbi Role of veins in regulation of pulmonary circulation
    Yuansheng Gao
    Division of Neonatology, Department of Pediatrics, Harbor UCLA Research and Education Institute, 1124 W Carson St, RB 1, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 288:L213-26. 2005
    ..In this review, the role of veins in regulation of the pulmonary circulation, particularly during the perinatal period and under certain pathophysiological conditions, is discussed...
  29. ncbi Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells
    Alexander Dietrich
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Karl von Frisch Str 1, 35043 Marburg, Germany
    Pharmacol Ther 112:744-60. 2006
    ..Therefore, they present important drug targets for future pharmacological interventions...
  30. ncbi A novel echocardiographic predictor of in-hospital mortality and mid-term haemodynamic improvement after pulmonary endarterectomy for chronic thrombo-embolic pulmonary hypertension
    Maxim Hardziyenka
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 28:842-9. 2007
    ....
  31. ncbi Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase
    Albert C Grobe
    Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59802, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1069-77. 2006
    ..Rather, the observed increase in oxidative stress is due, at least in part, to increased expression and activity of the NADPH oxidase complex and uncoupled eNOS due to elevated levels of BH(2)...
  32. ncbi Two temporal components within the human pulmonary vascular response to approximately 2 h of isocapnic hypoxia
    Nick P Talbot
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    J Appl Physiol 98:1125-39. 2005
    ..These findings demonstrate the presence of two distinct phases of hypoxic pulmonary vasoconstriction, which may result from two distinct underlying processes...
  33. ncbi Ca2+ sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium dependent
    Tom P Robertson
    Department of Physiology and Pharmacology, Institute of Comparative Medicine, University of Georgia, Athens, Georgia 30602 7389, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1121-6. 2003
    ..These results are consistent with sustained HPV being mediated by an endothelium-derived constrictor factor that is distinct from endothelin-1 and that elicits vasoconstriction via Ca(2+) sensitization...
  34. pmc Sequence optimization to reduce velocity offsets in cardiovascular magnetic resonance volume flow quantification--a multi-vendor study
    Marijn P Rolf
    Department of Physics and Medical Technology, ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 13:18. 2011
    ..This study is aimed at identifying correlations between protocol parameters and the resulting velocity error in clinical CMR flow measurements in a multi-vendor study...
  35. ncbi Intravascular ultrasound assessment of pulmonary vascular disease in patients with pulmonary hypertension
    E Bressollette
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    Chest 120:809-15. 2001
    ..The severity of structural abnormalities found on IVUS is directly correlated with hemodynamic findings and ET-1 levels. IVUS may provide useful additional information in the assessment of patients with PH...
  36. ncbi Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH
    Yuji Tada
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1556-63. 2007
    ....
  37. ncbi Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury
    Martin Westphal
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, USA
    Anesthesiology 102:954-61. 2005
    ....
  38. ncbi Evaluation of regional pulmonary perfusion using ultrafast magnetic resonance imaging
    D L Levin
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Magn Reson Med 46:166-71. 2001
    ..used to measure changes in signal intensity during the first pass of intravascular contrast through the pulmonary circulation. From this, mean transit time, relative blood volume, and relative blood flow were calculated...
  39. ncbi Basic features of hypoxic pulmonary vasoconstriction in mice
    Norbert Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Respir Physiol Neurobiol 139:191-202. 2004
    ..In summary, we have characterised HPV and established an experimental set-up optimized for investigation of the basic mechanisms of HPV in mice...
  40. pmc Noninvasive quantification of systemic-to-pulmonary collateral flow: a major source of inefficiency in patients with superior cavopulmonary connections
    Kevin K Whitehead
    Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Circ Cardiovasc Imaging 2:405-11. 2009
    ....
  41. pmc Preoperative evaluation of pulmonary artery morphology and pulmonary circulation in neonates with pulmonary atresia--usefulness of MR angiography in clinical routine
    Nadine Kawel
    Department of Diagnostic Imaging, University Children s Hospital Zurich, Zurich, Switzerland
    J Cardiovasc Magn Reson 12:52. 2010
    ..In those cases where surgery or conventional angiocardiography was performed results were compared...
  42. ncbi Dynamic perfusion MRI versus perfusion scintigraphy: prediction of postoperative lung function in patients with lung cancer
    Yoshiharu Ohno
    Department of Radiology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    AJR Am J Roentgenol 182:73-8. 2004
    ..To determine the capability of MRI as an alternative to scintigraphy, we evaluated correlations and the limits of agreement between predicted FEV(1,MRI) and postoperative FEV(1) and between predicted FEV(1,PS) and postoperative FEV(1)...
  43. ncbi Gravity is an important but secondary determinant of regional pulmonary blood flow in upright primates
    R W Glenny
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Appl Physiol (1985) 86:623-32. 1999
    ..Although important, gravity is not the predominant determinant of pulmonary perfusion heterogeneity in upright primates. Because of anatomic similarities, the same may be true for humans...
  44. pmc Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury
    Matthias Lange
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 39:718-24. 2011
    ....
  45. ncbi A model for educational simulation of infant cardiovascular physiology
    Jane A Goodwin
    Nemours Children s Clinic Jacksonville, 807 Children s Way, Jacksonville, FL 32207, USA
    Anesth Analg 99:1655-64, table of contents. 2004
    ..This infant cardiovascular model can form the basis for screen-based educational simulations. The model is also an essential step in attaining a full-body, model-driven infant simulator...
  46. ncbi Hypoxia, leukocytes, and the pulmonary circulation
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:715-21. 2005
    ..in support of the idea that circulating monocytes and/or mononuclear fibrocytes are recruited to the pulmonary circulation of chronically hypoxic animals and that these cells play an important role in the pulmonary hypertensive ..
  47. ncbi A novel model for post-transplant obliterative airway disease reveals angiogenesis from the pulmonary circulation
    Andre E Dutly
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, Toronto, ON, Canada
    Am J Transplant 5:248-54. 2005
    ..This model has revealed new insights into angiogenic potential of the pulmonary circulation.
  48. pmc Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow
    Shruti Sharma
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, United States
    Vascul Pharmacol 53:38-52. 2010
    ..Collectively, our findings suggest that NADPH oxidase and XO are major contributors to superoxide generation both during the normal development and during the development of pulmonary hypertension...
  49. ncbi Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome
    Anne Rabiller
    Laboratoire de Chirurgie Expérimentale UPRES, Centre Chirurgical Marie Lannelongue, Universite Paris Sud, 133 avenue de la Resistance, 92350 Le Plessis Robinson, Paris, France
    Am J Respir Crit Care Med 166:514-7. 2002
    ..iNOS by pulmonary intravascular macrophages might be related to translocated gut bacteria present in the pulmonary circulation. To test this hypothesis, we determined whether macrophage sequestration, lung iNOS expression and ..
  50. ncbi Prevention of hepatopulmonary syndrome and hyperdynamic state by pentoxifylline in cirrhotic rats
    B Sztrymf
    Laboratoire de Chirurgie Experimentale, Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil 2705, Centre Chirurgical Marie Lannelongue, Universite Paris Sud, Paris, France
    Eur Respir J 23:752-8. 2004
    ..These results support an important role for tumour necrosis factor-alpha in the genesis of hepatopulmonary syndrome...
  51. ncbi Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation
    R J Gryglewski
    Jagiellonian University, 16 Grzegorzecka str, 31 531 Cracow, Poland
    Med Sci Monit 7:1-16. 2001
    ..We looked for mechanisms of protective endothelial function, with a special respect to the differences between peripheral and pulmonary circulation.
  52. ncbi Appropriate additional pulmonary blood flow at the bidirectional Glenn procedure is useful for completion of total cavopulmonary connection
    Masahiro Yoshida
    Department of Cardiothoracic Surgery, Kobe Childre s Hospital, Kobe, Hyogo, Japan
    Ann Thorac Surg 80:976-81. 2005
    ..We assessed our experiences to clarify the effects of controlled additional pulmonary blood flow on outcomes after BDG...
  53. ncbi Effects of perinatal exposure to hypoxia upon the pulmonary circulation of the adult rat
    R D Jones
    Section of Respiratory Medicine, Division of Academic Medicine, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom
    Physiol Res 53:11-7. 2004
    ..01), and PGF2(2alpha) (1.40+/-0.14 vs. 2.47+/-0.44 mN/mm, P<0.05). Perinatal exposure to hypoxia had a profound effect upon the adult pulmonary circulation, which could predispose to cardiopulmonary diseases in adulthood.
  54. ncbi Assessment of normal flow patterns in the pulmonary circulation by using 4D magnetic resonance velocity mapping
    Pablo Bächler
    Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Magn Reson Imaging 31:178-88. 2013
    The purpose of this study was to analyze flow patterns in the pulmonary circulation of healthy volunteers by using 4D flow magnetic resonance imaging.
  55. pmc Inflow-weighted pulmonary perfusion: comparison between dynamic contrast-enhanced MRI versus perfusion scintigraphy in complex pulmonary circulation
    Yi Ru Lin
    Department of Electronic and Computer Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
    J Cardiovasc Magn Reson 15:21. 2013
    ..those measured by dynamic contrast-enhanced MRI (DCE-MRI) using indicator-dilution analysis in complex pulmonary circulation. Since PS offers the pre-capillary perfusion of the first-pass transit, we hypothesized that an inflow-..
  56. ncbi Efficiency differences in computational simulations of the total cavo-pulmonary circulation with and without compliant vessel walls
    Wendell Orlando
    Northwest Research Associates, Inc, Colorado Research Associates Division, 3380 Mitchell Lane, Boulder, CO 80301, USA
    Comput Methods Programs Biomed 81:220-7. 2006
    ..We have shown incorporating elasticity into numerical models of the total cavo-pulmonary connection is important when determining circuit efficiencies...
  57. ncbi Endothelium-derived mediators and hypoxic pulmonary vasoconstriction
    Philip I Aaronson
    Department of Respiratory Medicine and Allergy, Centre for Cardiovascular Biology and Medicine, Guy s, King s and St Thomas School of Medicine, 5th Floor Thomas Guy House, King s College London, Guy s Campus, London SE1 9RT, UK
    Respir Physiol Neurobiol 132:107-20. 2002
    ..In particular, we propose that in response to hypoxia the pulmonary vascular endothelium releases an as yet unidentified agent that causes Ca(2+) sensitisation in the smooth muscle...
  58. ncbi Calcium, mitochondria and oxygen sensing in the pulmonary circulation
    Jeremy P T Ward
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas School of Medicine, 5th Floor Thomas Guy House, King s College London, Guy s Campus, London SE1 9RT, UK
    Cell Calcium 36:209-20. 2004
    ....
  59. ncbi Magnitude and time course of acute hypoxic pulmonary vasoconstriction in man
    N W Morrell
    Department of Medicine, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK
    Respir Physiol 100:271-81. 1995
    ..We conclude that this technique has allowed us to monitor both the dynamic and steady state responses of the pulmonary circulation to lobar hypoxia in man.
  60. pmc Exercise stress echocardiography of the pulmonary circulation: limits of normal and sex differences
    Paola Argiento
    Department of Cardiology, Second University of Naples, Naples, Italy
    Chest 142:1158-65. 2012
    ..Exercise stress echocardiography has not been recommended in the diagnostic workup of pulmonary hypertension because of insufficient certainty about feasibility and limits of normal...
  61. ncbi Multiscale modeling of the cardiovascular system: application to the study of pulmonary and coronary perfusions in the univentricular circulation
    Katia Laganà
    Laboratory of Biological Structure Mechanics, Bioengineering Department, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy
    J Biomech 38:1129-41. 2005
    ..In the CS option, a smaller percentage of aortic flow is distributed to the coronary circulation, while that percentage rises for the MBTS. These findings may have important implications for coronary blood flow and ventricular function...
  62. ncbi Obstructive sleep apnea syndrome and the pulmonary circulation
    Emmanuel Weitzenblum
    Division of Pneumology, Hopital de Hautepierre, Strasbourg, France
    Ital Heart J 6:795-8. 2005
    ....
  63. ncbi [Role of nitric oxide in the control of the pulmonary circulation: physiological, pathophysiological, and therapeutic implications]
    Carlos Alan Dias-Junior
    Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    J Bras Pneumol 34:412-9. 2008
    ..This review aimed at outlining the role played by NO in the control of pulmonary circulation, both under physiological and pathophysiological conditions...
  64. ncbi Hemodynamic and humoral effects of atrial natriuretic peptide on pulmonary circulation after cardiac surgery
    Keisuke Morimoto
    Department of Thoracic and Cardiovascular Surgery, Tottori Prefectural Central Hospital, Tottori, Japan
    Surg Today 38:395-8. 2008
    ..peptide (h-ANP) elicits biological effects such as natriuresis, diuresis, and vasodilation, and plays a role in regulating pulmonary circulation. We conducted this clinical study to define its role and elucidate its mechanisms.
  65. ncbi Proximal pulmonary arterial obstruction decreases the time constant of the pulmonary circulation and increases right ventricular afterload
    Alberto Pagnamenta
    Department of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium
    J Appl Physiol (1985) 114:1586-92. 2013
    The time constant of the pulmonary circulation, or product of pulmonary vascular resistance (PVR) and compliance (Ca), called the RC-time, has been reported to remain constant over a wide range of pressures, etiologies of pulmonary ..
  66. ncbi 4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice
    Fabian Spöhr
    Department of Anaesthesiology, Ruprecht Karls University, Heidelberg, Germany
    Anesthesiology 107:597-604. 2007
    ..Voltage-gated potassium channels play a central role in mediating HPV. The aim of this study was to determine whether 4-aminopyridine (4-AP), a known voltage-gated potassium channel inhibitor, may restore HPV in sepsis...
  67. pmc Decreased time constant of the pulmonary circulation in chronic thromboembolic pulmonary hypertension
    Robert V Mackenzie Ross
    Pulmonary Vascular Disease Unit, Papworth Hospital, Cambridge, UK
    Am J Physiol Heart Circ Physiol 305:H259-64. 2013
    ..It has recently been shown that the time constant of the pulmonary circulation (RC time constant), or PVR × Ca, remains unaltered in various forms and severities of pulmonary ..
  68. ncbi Impact of oxygen inhalation on the pulmonary circulation: assessment by magnetic resonance (MR)-perfusion and MR-flow measurements
    Sebastian Ley
    Department of Pediatric Radiology, Children s Hospital University Heidelberg, Heidelberg, Germany
    Invest Radiol 42:283-90. 2007
    ..However, the effect of hyperoxia on the pulmonary circulation is not yet fully understood...
  69. ncbi Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension
    Eugenia Mata-Greenwood
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611 3008, USA
    Am J Physiol Lung Cell Mol Physiol 285:L209-21. 2003
    ..Our data suggest that increased pulmonary blood flow dysregulates TGF-beta1 signaling, producing imbalance between pro- and antiangiogenic signaling that may be important in vascular remodeling in shunted lambs...
  70. pmc Fasudil inhibits the myogenic response in the fetal pulmonary circulation
    Pierre Tourneux
    The Pediatric Heart Lung Center, Sections of Neonatology and Pulmonary Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Am J Physiol Heart Circ Physiol 295:H1505-13. 2008
    In addition to high pulmonary vascular resistance (PVR) and low pulmonary blood flow, the fetal pulmonary circulation is characterized by mechanisms that oppose vasodilation...
  71. ncbi Time-resolved MR angiography of the thorax
    Derek G Lohan
    Department of Radiology, David Geffen School of Medicine at the University of California, Los Angeles, 10945 Le Conte Avenue, Suite 3371, Peter V Ueberroth Building, Los Angeles, CA 90095 7206, USA
    Magn Reson Imaging Clin N Am 16:235-48, viii. 2008
    ..This article considers the current role of TR-MRA in thoracic imaging, illustrating many of its clinical applications, and potential future of this recent approach to noninvasive dynamic vascular evaluation...
  72. ncbi Nitric oxide and milrinone: combined effect on pulmonary circulation after Fontan-type procedure: a prospective, randomized study
    Jiming Cai
    Department of Cardiovascular and Thoracic Surgery, Shanghai Children s Medical Center, Shanghai Jiao Tong University School of Medicine formerly Shanghai Second Medical University, Shanghai, China
    Ann Thorac Surg 86:882-8; discussion 882-8. 2008
    ..We hypothesized that their combined use could maximally stabilize the pulmonary circulation after Fontan operation.
  73. pmc Targeted delivery of nucleic-acid-based therapeutics to the pulmonary circulation
    Ramalinga Kuruba
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    AAPS J 11:23-30. 2009
    ..This review summarizes the recent progress that has been made in our laboratory along these research directions. Factors that affect pulmonary nucleic acids delivery are also discussed...
  74. pmc Major differences in the pulmonary circulation between birds and mammals
    John B West
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    Respir Physiol Neurobiol 157:382-90. 2007
    ..The work suggests a pathogenesis for pulmonary hypertension syndrome in chickens which costs the broiler industry $1 billion per year...
  75. ncbi Temporal correlation-based dynamic contrast-enhanced MR imaging improves assessment of complex pulmonary circulation in congenital heart disease
    Shang Yueh Tsai
    Department of Electrical Engineering, National Taiwan University, Taipei, and Department of Radiology, Kaohsiung Veterans General Hospital, Taiwan, R O C
    Magn Reson Med 56:517-26. 2006
    ..mapping method is proposed to help bolus chasing during dynamic contrast-enhanced (DCE) MRI of complex pulmonary circulation (CPC) in patients with congenital heart disease...
  76. ncbi Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia
    C M Littler
    Cardiovascular Pulmonary Research Laboratory, B 133, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1083-93. 2005
    ..that loss of PKC-epsilon would decrease the contractile and/or structural response of the murine pulmonary circulation to chronic hypoxia (Hx)...
  77. ncbi Measurement of pulmonary circulation parameters using time-resolved MR angiography in patients after Ross procedure
    Anna Lakoma
    Department of Radiology, Northwestern University, 737 N Michigan Ave, Ste 1600, Chicago, IL 60611, USA
    AJR Am J Roentgenol 194:912-9. 2010
    The purposes of our study were to retrospectively evaluate the pulmonary circulation parameters of pulmonary transit time and pulmonary blood volume in patients after Ross procedures using time-resolved MR angiography and to investigate ..
  78. ncbi On occasion of 800th anniversary of birth of Ibn al-Nafis--discoverer of cardiac and pulmonary circulation
    Izet Masic
    Academy of Medical Sciences, Sarajevo, Bosnia and Herzegovina
    Med Arh 64:309-13. 2010
    ..He, 250 years ago Servet, (Michael Servetus, XVI century) reveals the truly describes the small or pulmonary circulation, but also gives a description of the great forerunner of the bloodstream...
  79. ncbi Endothelial nitric oxide synthase expression in systemic and pulmonary circulation of streptozotocin induced diabetic rats: comparison using image analysis
    P Sridulyakul
    Field of Medical Science, Graduate School, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Clin Hemorheol Microcirc 29:423-8. 2003
    ..On the other hand, eNOS levels in DM lungs was increased, compared to CON lungs. Therefore, it may be concluded that high, not low, flow-mediated eNOS expression is a good measure of hyperglycemic-induced endothelial dysfunction...
  80. ncbi Differential response of the systemic and pulmonary circulation related to disease severity of cirrhosis
    F Acosta
    Liver Transplantation Unit, University Hospital V, Arrixaca, Murcia, Spain
    Transplant Proc 37:3889-90. 2005
    ..We sought to assess how the severity of disease, which was stratified according to the Child-Pugh criteria, influences the pulmonary and systemic circulation among patients undergoing liver transplantation...
  81. ncbi Effects of cigarette smoke and hypoxia on pulmonary circulation in the guinea pig
    E Ferrer
    Dept of Pulmonary Medicine, Hospital Clinic, Barcelona, Spain
    Eur Respir J 38:617-27. 2011
    ..the present study was to investigate the effects of CS and CH, as single factors or in combination, on the pulmonary circulation in the guinea pig. 51 guinea pigs were exposed to CS for 12 weeks and 32 were sham-exposed...
  82. ncbi The right ventricle and pulmonary circulation: basic concepts
    CLIFFORD R GREYSON
    Department of Veterans Affairs Medical Center and the University of Colorado, Denver, Colorado, USA
    Rev Esp Cardiol 63:81-95. 2010
    The primary purpose of the right ventricle and pulmonary circulation is gas exchange...
  83. ncbi Pulsatile pulmonary perfusion with oxygenated blood ameliorates pulmonary hemodynamic and respiratory indices in low-risk coronary artery bypass patients
    Francesco Santini
    Division of Cardiac Surgery, University of Verona, Verona, Italy
    Eur J Cardiothorac Surg 40:794-803. 2011
    ..The safety and the efficacy of pulsatile pulmonary perfusion (PPP) during CPB were analyzed. Preliminary results of the first PPP trial in human beings are reported...
  84. ncbi The impact of pulmonary venous hypertension on the pulmonary circulation in the young
    Thomas J Kulik
    The Pulmonary Hypertension Program Department of Cardiology, Division of Cardiac Critical Care, Department of Nursing Patient Services, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Congenit Heart Dis 6:603-7. 2011
    ..8 months) and (2) how pulmonary arteriolar resistance changes after mitral valve replacement...
  85. ncbi Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation
    Noriyuki Homma
    Cardiovascular Pulmonary Research Laboratory, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    J Cardiovasc Pharmacol 50:697-702. 2007
    ..voltage-gated Ca influx-mediated vasoconstrictor) is augmented in the chronically hypoxic hypertensive rat pulmonary circulation probably through increased Rho kinase-mediated Ca sensitization...
  86. ncbi Prospective comparison of MR lung perfusion and lung scintigraphy
    Y Berthezene
    Department of Radiology, CREATIS UMR 5515, Hopital Cardiologique, Lyon, France
    J Magn Reson Imaging 9:61-8. 1999
    ..48). The data showed an overall good interobserver agreement (kappa = 0.66). MR perfusion of the lung is a promising technique in detecting lung perfusion defects...
  87. pmc Exercise stress echocardiography for the study of the pulmonary circulation
    P Argiento
    Dept of Cardiology, Second University of Naples, Naples, Italy
    Eur Respir J 35:1273-8. 2010
    ..We conclude that exercise echocardiography of the pulmonary circulation is feasible and provides realistic resistance and compliance estimations...
  88. pmc The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
    K A Fagan
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262, USA
    J Clin Invest 103:291-9. 1999
    ..vasoconstriction and development of hypoxic pulmonary hypertension (PHTN) are unique properties of the pulmonary circulation. The pulmonary endothelium produces vasoactive factors, including nitric oxide (NO), that modify these ..
  89. ncbi Pulmonary vascular responses during acute and sustained respiratory alkalosis or acidosis in intact newborn piglets
    J B Gordon
    Department of Pediatrics, Medical College of Wisconsin, and Zablocki VAMC, Milwaukee, USA
    Pediatr Res 46:735-41. 1999
    ....
  90. ncbi Exhaled nitric oxide in isolated pig lungs
    G Cremona
    Department of Respiratory Physiology, Papworth Hospital, Cambridge, United Kingdom
    J Appl Physiol 78:59-63. 1995
    ..0 mmHg.l-1.min and a decrease in NO to 1.5 +/- 1.0 ppb. Addition of autologous blood to the perfusate of four lungs caused no change in PVR from baseline but decreased exhaled NO to 2.7 +/- 0.5 ppb.(ABSTRACT TRUNCATED AT 250 WORDS)..
  91. ncbi Role of airway nitric oxide on the regulation of pulmonary circulation by carbon dioxide
    Y Yamamoto
    Department of Internal Medicine, School of Nursing, Asahikawa Medical College, Asahikawa 078-8510, Japan
    J Appl Physiol 91:1121-30. 2001
    ....
  92. ncbi Adenosine and ATP cause nitric oxide-dependent pulmonary vasodilation in fetal lambs
    G G Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biol Neonate 78:220-9. 2000
    ..The activation of K(+)(ATP) channels plays a role in adenosine-induced pulmonary vasodilation. The mechanism by which ATP causes NO release and pulmonary vasodilation requires further investigation...
  93. ncbi Interactive effects of mechano- and chemo-receptor inputs on cardiorespiratory outputs in the toad
    T Wang
    Biosciences, The University of Birmingham, Edgbaston, UK
    Respir Physiol Neurobiol 140:63-76. 2004
    ....
  94. ncbi Capacitative calcium entry: a central role in hypoxic pulmonary vasoconstriction?
    Jeremy P T Ward
    Am J Physiol Lung Cell Mol Physiol 289:L2-4. 2005
  95. ncbi Evidence for uneven distribution of L-type calcium channels in rat pulmonary circulation
    B R Walker
    Department of Physiology, University of New Mexico School of Medicine, Albuquerque 87131 5321, USA
    Am J Physiol 269:H2051-6. 1995
    ..These data suggest that a greater density of L-type calcium channels may exist within the arterial segment of the pulmonary circulation than in the veins.
  96. ncbi Current perspectives modern hemodynamic evaluation of the pulmonary circulation. Application to pulmonary arterial hypertension and embolic pulmonary hypertension
    Robert Naeije
    Department of Pathophysiology, Faculty of Medicine of the Free University of Brussels, Brussels, Belgium
    Ital Heart J 6:784-8. 2005
    The hemodynamic evaluation of the pulmonary circulation normally includes the measurements of mean pulmonary artery pressure and a calculation of pulmonary vascular resistance (PVR)...
  97. ncbi Vascular impedance analysis in human pulmonary circulation
    Qinlian Zhou
    Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA
    Biomed Sci Instrum 42:470-5. 2006
    ..A mathematical model representing the entire system of human pulmonary circulation was constructed based on experimentally measured morphometric and elasticity data of the vessels...
  98. pmc Improved accuracy in flow mapping of congenital heart disease using stationary phantom technique
    Thomas A Miller
    Department of Pediatrics, Maine Medical Center, 22 Bramhall St, Portland, ME, USA
    J Cardiovasc Magn Reson 11:52. 2009
    ..Previous reports have highlighted the presence of inherent errors in flow mapping that are improved with the use of a stationary phantom control. To our knowledge, these studies have only been performed in healthy volunteers...
  99. ncbi Pathologic assessment of vasculopathies in pulmonary hypertension
    Giuseppe G Pietra
    Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 43:25S-32S. 2004
    ....
  100. ncbi Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema
    Fiona Murray
    Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0725, USA
    Respir Physiol Neurobiol 151:192-208. 2006
    ..in caveolae, may play a role in excitation-contraction coupling and perhaps in O(2)-sensing in the pulmonary circulation and thereby may contribute to the development of HAPE...
  101. ncbi Imaging techniques and the evaluation of the right heart and the pulmonary circulation
    Javier Sanz
    The Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY, USA
    Rev Esp Cardiol 63:209-23. 2010
    Since the right side of the heart and the pulmonary circulation are regarded as secondary components of the circulatory system, their role in disease has traditionally not received the same attention as their counterparts in the systemic ..

Research Grants65

  1. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease of the pulmonary circulation affecting children and adults...
  2. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..PPHN delivered at term to investigate the role of mitochondrial O2[unreadable]- in the transition of pulmonary circulation and oxygenation at birth. These studies will identify an important new source of oxidative stress in PPHN...
  3. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..This project will provide novel information on the unique control of pulmonary circulation by subcellular local Ca2+ signals...
  4. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..investigate the novel hypothesis that antenatal betamethasone will improve the postnatal adaptation of pulmonary circulation and oxygenation in PPHN...
  5. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..oxide (NO) production and NO/cyclic guanosine 5'monophosphate (cGMP)- dependent vasorelaxation in the pulmonary circulation. Alternatively, pulmonary vascular cGMP levels can also be elevated via inhibition of phosphodiesterase ..
  6. Pulmonary Vasoreactivity Following Chronic Hypoxia
    Thomas C Resta; Fiscal Year: 2012
    ..VSM membrane depolarization, NOX-derived ROS generation, and RhoA/ROK signaling in the hypertensive pulmonary circulation. Collectively, these outcomes are expected to fundamentally advance our understanding of signaling ..
  7. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..Our findings to date are limited, however, by an inability to assess directly the pulmonary circulation, lack of full-lung CT scans and post-bronchodilator spirometry, and mostly cross-sectional findings...
  8. NO-Zinc Signaling in Intact Pulmonary Endothelium
    CLAUDETTE MARIE ST CROIX; Fiscal Year: 2010
    Although hypoxic pulmonary vasoconstriction (HPV) has been reported to affect all segments of the pulmonary circulation relatively little is known regarding vasoconstriction of small (<50um) intra-acinar arterioles...
  9. Recombinant Polymers for Transarterial Chemoembolization of Liver Cancer
    AZADEH POURSAID; Fiscal Year: 2013
    ..beads, fracturing of beads while under strain in the catheter, off target embolization particularly in pulmonary circulation, elution of only charged small molecule therapeutics, non-degradability, limited tumor depth penetration, ..
  10. RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
    Luis A Ortiz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The pulmonary circulation is coupled with the right ventricular (RV) function in health and disease and RV failure (RVF) is the immediate cause of death in patients with idiopathic pulmonary fibrosis ..
  11. Role of Acid-Sensing Ion Channels in Pulmonary Vascular Smooth Muscle Store-Opera
    Nikki L Jernigan; Fiscal Year: 2012
    ..Lay Relevance: The pressure in the pulmonary circulation is relatively low compared to the rest of the body...
  12. Properties of Clca Channels in Vascular Myocytes
    Normand Leblanc; Fiscal Year: 2009
    ..arterial smooth muscle cells, and how this might impact on the electrical and vasoactive properties of the pulmonary circulation. 4 Specific Aims are proposed in this grant: (1) determine the effect of general phosphorylation status on ..
  13. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2012
    ..stress accompanying these pathologies results in increased levels of oxidized phospholipids (OxPL) in the pulmonary circulation. We have previously characterized a group of barrier-protective OxPLs in vitro and in vivo and described ..
  14. Vascular Smooth Muscle Function in Pulmonary Hypertension
    Nikki L Jernigan; Fiscal Year: 2013
    ..undefined mechanisms of ASIC1 membrane trafficking, channel regulation and Ca2+ influx in the normal pulmonary circulation. In addition, our work is at the forefront of determining how hypoxia affects ASIC1 function in the ..
  15. Training in Lung Molecular and Cell Pathobiology-Phase II
    Joseph A Lasky; Fiscal Year: 2013
    ..The main research areas are in mechanisms of lung fibrosis, lung cancer, pulmonary circulation, asthma, COPD, gene therapy, and effects of inhaled toxicants on the lung and airway inflammation ..
  16. Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRI
    Susan R Hopkins; Fiscal Year: 2013
    ..on characterization of underlying nonlinear behavior can provide new metrics for evaluating the human pulmonary circulation. If successful, this may provide biomarkers for the early detection and classification of disease, and a ..
  17. CYTOSKELETAL REGULATION OF LUNG ENDOTHELIAL PATHOBIOLOGY
    Joe G N Garcia; Fiscal Year: 2012
    ..We anticipate our work will quickly facilitate development of new strategies and targets to limit the adverse effects of the injured pulmonary circulation.
  18. 3D Ultrasound Guidance of Interventional Devices
    Stephen William Smith; Fiscal Year: 2012
    ..guidance of the deployment of the vena cava filter which prevents a venous thrombus from embolizing to the pulmonary circulation. (2) To investigate 3D ultrasound guidance of the aortic stent graft which isolates a weakened abdominal ..
  19. O2 sensing in the human and rabbit ductus arteriosus.
    Stephen L Archer; Fiscal Year: 2013
    ..ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  20. Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients
    Nader Najafi; Fiscal Year: 2013
    ..the hemi-Fontan procedure (HFP) re-routes systemic venous blood from the upper body and head into the pulmonary circulation without passing through an intervening ventricular chamber...
  21. Lung Endothelial Cell Phenotypes
    Troy Stevens; Fiscal Year: 2013
    ..In the pulmonary circulation, endothelium in extra-alveolar blood vessels differs markedly from those in capillary segments...
  22. Novel Peptide for Dynamic Regulation of Lung Endothelium NOS/cGMP Functions
    Jawaharlal M Patel; Fiscal Year: 2011
    ..of cyclic guanosine 5'monophosphate (cGMP) production and NO/cGMP-dependent vasorelaxation in the pulmonary circulation. Alternatively, pulmonary vascular cGMP levels can also be elevated via inhibition of phosphodiesterase ..
  23. Fibroblasts and Mononuclear Fibrogenic Cells Drive Right Ventricular Pulmonary Ar
    Kurt R Stenmark; Fiscal Year: 2013
    ..disease and high pulmonary vascular resistance but rather to complex interactions between the pulmonary circulation and the RV...
  24. Perinatal regulation of TGF-beta1 during vascular remodeling
    Stephen M Black; Fiscal Year: 2010
    ..to suffer morbidity and late mortality, in part, because of the abnormal structural development of the pulmonary circulation, which varies depending on the amount of pulmonary blood flow...
  25. Grover Conference on Risk Factors in Pulmonary Hypertension
    Karen A Fagan; Fiscal Year: 2011
    ..Invited speakers include members of the ATS Pulmonary Circulation and Respiratory Cell and Molecular Biology Assemblies at the ATS representing active research groups ..
  26. Extracellular ATP as regulator of hypoxia-induced vasa vasorum neovascularization
    Evgenia V Gerasimovskaya; Fiscal Year: 2012
    ..a key component and frequently life-threatening consequence, of vascular diseases in both the systemic and pulmonary circulation. In a neonatal model of hypoxic pulmonary hypertension, we have demonstrated that hypoxia-induced ..
  27. Non Viral Gene Therapy for Lung Injury
    Song Li; Fiscal Year: 2012
    ..1: To develop a novel polymer-based delivery system that is highly efficient in selective gene delivery to pulmonary circulation with minimal toxicity...
  28. Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart Valves
    Michael S Sacks; Fiscal Year: 2010
    ..polymers, tissue engineered pulmonary valves (TEPV) have been fabricated and have functioned in the pulmonary circulation of growing lambs for up to 20 weeks, with tissue evolving into a differentiated layered structure ..
  29. Effect of Pulmonary Vasodilation on the Efficacy of Cardiopulmonary Resuscitation
    Gregory P Walcott; Fiscal Year: 2012
    ..Any constriction to blood flow in the pulmonary circulation during chest compressions will limit blood flow in the systemic circulation and dilation of the pulmonary ..
  30. Chronic hypoxia and pulmonary vascular smooth muscle
    Larissa A Shimoda; Fiscal Year: 2010
    ..endothelial cells is required for and/or accelerates HIF-dependent pathophysiological effects of CH in the pulmonary circulation;2) elucidate the mechanism(s) by which ET-1 modulates HIF-1 expression and 3) determine whether HIF-1 is ..
  31. Cardioscopy New Platform for Less Invasive Surgery on the Beating Heart
    Tomislav Mihaljevic; Fiscal Year: 2013
    ..vein will be used to occlude the PA, isolate the LV from the right ventricle and flush blood out of the pulmonary circulation into the LV using a clear imaging fluid...
  32. Lung Vascular Disease in Infants and Children: Mechanisms and Treatment
    Kurt R Stenmark; Fiscal Year: 2012
    ..growth and its connection with alveolar growth is unfortunate, because developmental abnormalities of the pulmonary circulation contribute to the pathogenesis of several important neonatal cardiopulmonary disorders including pulmonary ..
  33. Development of Percutaneous DLC for Total Cavo-pulmonary Assistance
    Dongfang Wang; Fiscal Year: 2011
    ..The Fontan procedure results in a blood flow pattern of a passively filled pulmonary circulation and a single ventricle to pump blood to the systemic circulation...
  34. MR predictors of infection, inflammation, and structural lung damage in CF
    John Paul Clancy; Fiscal Year: 2013
    ..In this proposal, we hypothesize that magnetic resonance imaging (MRI) of the lung and pulmonary circulation has the potential to serve as a sensitive and portable tool to monitor early CF lung disease, and that ..
  35. Translational Pulmonary Vascular Biology
    Mark T Gladwin; Fiscal Year: 2013
    ..and basic researchers in a translational approach to vascular biology, with a specific emphasis on the pulmonary circulation. While there are many T32 programs focused on systemic vascular biology, to our knowledge there is not a ..
  36. PERINATAL PULMONARY CIRCULATION--VASOACTIVE MEDIATORS
    Michael Heymann; Fiscal Year: 1999
    ....
  37. Piezoelectric Pump to supply Ventricular Assist Device for Fontan Patients
    CONAL O'NEILL; Fiscal Year: 2013
    ..device will be characterized in vitro to demonstrate that the system can increase fluid flow through the pulmonary circulation while reducing systemic venous pressure in a mock Fontan fluidic circuit...
  38. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..vasodilators and vasoconstrictors (NO and ET-1 respectively) have been implicated in the hypertensive pulmonary circulation in experimental models of PHT as well as in the human disease...
  39. INTRATHORACIC ARTIFICIAL LUNGS
    LYLE MOCKROS; Fiscal Year: 2000
    ..ITALs). These devices are to attached to the pulmonary circulation, utilize the right ventricle to drive blood flow, and perform the gas transfer function of the natural ..
  40. BRONCHIAL CIRCULATION AND LUNG FLUID BALANCE
    George Kramer; Fiscal Year: 1993
    ..selectively increase the permeability of bronchial venules while having relatively little effect on the pulmonary circulation. The vessels of the bronchial circulation exhibit greater vasodilation during inflammation than those of ..
  41. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..Our studies suggest that MIF accumulates within the lung during sepsis and is released into the pulmonary circulation contemporaneous with the onset of cardiac dysfunction...
  42. CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICS
    Alan Stephenson; Fiscal Year: 2002
    ..laboratory is to define the role of products of arachidonic acid (AA) metabolism, in the regulation of the pulmonary circulation under physiological as well as pathophysiological conditions...
  43. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
    ..for endothelial NO synthesis, suggested a novel mechanism for the control of vascular resistance in the pulmonary circulation. In this construct, as the RBC is increasingly deformed by increments in the velocity of blood flow ..
  44. FLUID DYNAMICS OF RIGHT HEART BYPASS OPERATIONS
    Carol Lucas; Fiscal Year: 1999
    ..performed to improve pulmonary blood flow in infants with congenital defects that interrupt the pulmonary circulation depends on the procedures and materials selected and the ability of the intervention to accommodate for ..
  45. REGULATORY REFLEXES FROM ISOLATED PULMONARY
    JERRY GREEN; Fiscal Year: 1991
    ..bypass preparation which will allow us to control blood flow, venous pressures, and blood gases in the pulmonary circulation independently of those in the systemic circulation...
  46. Bronchial circulation blocks pulmonary oxidant injury
    David Pearse; Fiscal Year: 2006
    ..The systemic bronchial circulation interacts with the pulmonary circulation by supplying vasa vasorum to the pulmonary arteries and veins and draining via bronchopulmonary ..
  47. EFFECTS OF ESTRADIOL ON PERINATAL PULMONARY BLOOD FLOW
    Thomas Parker; Fiscal Year: 2004
    ..fellowship training at The University of Colorado, he developed an interest in regulation of the perinatal pulmonary circulation. He has extensive experience in whole animal studies of fetal and neonatal pulmonary blood flow in the ..
  48. Pulmonary Hypertension following Intermittent Hypoxia
    Karen Fagan; Fiscal Year: 2006
    ..However, the effect of intermittent hypoxia on the pulmonary circulation is unknown...
  49. NO/CGMP RELAXATION IN PULMONARY HYPERTENSION
    Brian Fouty; Fiscal Year: 2000
    ..in smooth muscle cells from conduit pulmonary arteries or from other organs, however, and not from the pulmonary circulation that most of the NO/cGMP-dependent relaxation occurs independently of PKG...
  50. ROLE OF ENDOTHELIUM IN PULMONARY VASOREACTIVITY
    CARL GRUETTER; Fiscal Year: 1992
    ..interactions, or aberrations in these interactions, may be involved in the changes which occur in the pulmonary circulation under physiological and pathophysiological conditions...
  51. PULMONARY MICROCIRCULATORY HEMODYNAMICS
    WILTZ WAGNER; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): New evidence suggests that the pulmonary circulation has unexpected forms of regulation, both in the arteries and within capillaries...
  52. Optical Coherence Tomography for Pulmonary Circulation
    Mark Brezinski; Fiscal Year: 2005
    ..Development of an OCT Imaging Catheter, Aim 2. Assessing the Pulmonary Veins Ablation in an Animal Model, Aim 3. Vascular Assessments In Vitro, Aim 4. OCT Elastography and Aim 5. OCT Imaging will be performed in an Animal Model of PTN. ..
  53. VASCULAR REMODELING: THE DUCTUS ARTERIOSUS MODEL
    Beverly Koller; Fiscal Year: 2004
    ..The DA is an arterial connection in the fetus that directs blood away from the pulmonary circulation and towards the placenta where oxygenation occurs...
  54. Estradiol Metabolites for Treatment of Pulmonary Hypertension
    Stevan Tofovic; Fiscal Year: 2007
    ..This orphan disease is characterized by progressive increase in pressure in pulmonary circulation and vascular remodeling of small size pulmonary arteries that include proliferation of endothelial cells (..
  55. LIPID-MEDIATED GENE TRANSFER TO PULMONARY ENDOTHELIUM
    Song Li; Fiscal Year: 2004
    DESCRIPTION (Adapted from the applicant's abstract): Somatic gene transfer to the pulmonary circulation may be useful in treating pulmonary hypertension, adult respiratory distress syndrome or metastatic disease to the lung...
  56. CBC-NO: SELECTIVE PULMONARY VASODILATOR FOR SEPSIS
    Andrew Salzman; Fiscal Year: 2000
    ..a novel class of soluble nitrovasodilators (diazeniumdiolate pro-drugs), which are selective for the pulmonary circulation when administered by an aerosol route...
  57. CARDIOPULMONARY SURGICAL RESEARCH
    Albert Hyman; Fiscal Year: 1993
    The objective of this proposal is to improve our understanding of the regulatory mechanisms in the pulmonary circulation that are of endothelial origin...
  58. CARDIOVASCULAR DETERMINANTS OF GAS EXCHANGE DYNAMICS
    KATHY SIETSEMA; Fiscal Year: 1991
    ..and range of these responses, and the alterations in responses brought about by abnormalities in the pulmonary circulation. It is well appreciated that in the steady state, measurements of oxygen uptake in the lungs (VO2) reflect ..
  59. PATHOPHYSIOLOGY OF THE PULMONARY CIRCULATION
    LEON FARHI; Fiscal Year: 1990
    The six projects constituting this application deal with interrelated aspects of the pulmonary circulation in health and disease...
  60. HYPOXIA AND ET-1 EFFECT ON PA SMC EFFECT ON CHANNELS
    David Rodman; Fiscal Year: 2002
    DESCRIPTION: Cellular mechanisms regulating tone in the chronically hypoxic pulmonary circulation are poorly defined...
  61. CONFERENCE ON ION FLUX IN PULMONARY VASCULAR CONTROL
    Edward Weir; Fiscal Year: 1992
    ..This is the sixth in a series of Grover Conferences on the Pulmonary Circulation. The proceedings of prior meetings have appeared in Chest (1985), the American Review of Respiratory ..
  62. MECHANISMS OF ABNORMAL PERINATAL VASOREACTIVITY
    STEVEN ABMAN; Fiscal Year: 1992
    ..mechanisms contributing to altered vasoreactivity or structural abnormalities of the perinatal pulmonary circulation following exposure to chronic intrauterine hypoxia and hypertension are not known...
  63. DIAGNOSIS AND TREATMENT OF PULMONARY HYPERTENSION
    Edward Weir; Fiscal Year: 1990
    ..This is the fourth in a series of Grover Conferences on the Pulmonary Circulation. The proceedings of prior meetings, which have considered basic science topics, have been published either ..
  64. INTERACTIONS OF BLOOD AND THE PULMONARY CIRCULATION
    Edward Weir; Fiscal Year: 2000
    A conference on interactions between blood and the pulmonary circulation will be held in Colorado from September 6-10, 2000. This is the tenth in a series of conferences on the pulmonary circulation...
  65. NOS GENE TRANSFER IN PULMONARY HYPERTENSION
    David Rodman; Fiscal Year: 2002
    ..nitric oxide (NO) production and superoxide-mediated NG destruction in the normal and hypoxic/hypertensive pulmonary circulation, in an effort to establish genes of interest for gene transfer in pulmonary hypertension (PHTN)...