ventricular remodeling

Summary

Summary: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.

Top Publications

  1. ncbi The inflammatory response in myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Cardiovasc Res 53:31-47. 2002
  2. ncbi Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    Francis G Spinale
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Physiol Rev 87:1285-342. 2007
  3. pmc Regulation of the inflammatory response in cardiac repair
    Nikolaos G Frangogiannis
    Family Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 110:159-73. 2012
  4. ncbi Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    Ryota Uemura
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Circ Res 98:1414-21. 2006
  5. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
  6. pmc The role of TGF-beta signaling in myocardial infarction and cardiac remodeling
    Marcin Bujak
    Section of Cardiovascular Sciences, One Baylor Plaza M S F 602, Baylor College of Medicine, and Methodist DeBakey Heart Center, Houston, TX 77030, USA
    Cardiovasc Res 74:184-95. 2007
  7. ncbi Oxidative stress and left ventricular remodelling after myocardial infarction
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cardiovasc Res 81:457-64. 2009
  8. doi Cardiac plasticity
    Joseph A Hill
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    N Engl J Med 358:1370-80. 2008
  9. ncbi Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction
    Chung Lieh Hung
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 56:1812-22. 2010
  10. pmc MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis
    Yanjun Qin
    Department of Emergency, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
    Int J Med Sci 9:413-23. 2012

Detail Information

Publications269 found, 100 shown here

  1. ncbi The inflammatory response in myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Cardiovasc Res 53:31-47. 2002
    ..Elucidating the complex interactions and regulatory mechanisms responsible for cardiac repair may allow us to design effective inflammation-related interventions for the treatment of myocardial infarction...
  2. ncbi Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    Francis G Spinale
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Physiol Rev 87:1285-342. 2007
    ....
  3. pmc Regulation of the inflammatory response in cardiac repair
    Nikolaos G Frangogiannis
    Family Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 110:159-73. 2012
    ..Understanding of inhibitory and proresolving signals in the infarcted heart and identification of patients with uncontrolled postinfarction inflammation and defective cardiac repair is needed to design novel therapeutic strategies...
  4. ncbi Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    Ryota Uemura
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Circ Res 98:1414-21. 2006
    ..Preconditioning of BMSCs enhanced their survival and ability to attenuate LV remodeling, which was attributable, in part, to paracrine effects...
  5. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
    ..Recent research suggests that therapies targeting the expression, synthesis, or activation of the enzymes responsible for ECM homeostasis might represent novel opportunities to modify the natural progression of HHD...
  6. pmc The role of TGF-beta signaling in myocardial infarction and cardiac remodeling
    Marcin Bujak
    Section of Cardiovascular Sciences, One Baylor Plaza M S F 602, Baylor College of Medicine, and Methodist DeBakey Heart Center, Houston, TX 77030, USA
    Cardiovasc Res 74:184-95. 2007
    ..TGF-beta is also a key mediator in the pathogenesis of hypertrophic and dilative ventricular remodeling by stimulating cardiomyocyte growth and by inducing interstitial fibrosis...
  7. ncbi Oxidative stress and left ventricular remodelling after myocardial infarction
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cardiovasc Res 81:457-64. 2009
    ..Since the extent of LV remodelling is a major predictor of prognosis of the patients with MI, the therapeutic approach to attenuating LV remodelling is critically important...
  8. doi Cardiac plasticity
    Joseph A Hill
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    N Engl J Med 358:1370-80. 2008
  9. ncbi Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction
    Chung Lieh Hung
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 56:1812-22. 2010
    ..We sought to investigate the clinical prognostic value of longitudinal and circumferential strain (S) and strain rate (SR) in patients after high-risk myocardial infarction (MI)...
  10. pmc MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis
    Yanjun Qin
    Department of Emergency, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
    Int J Med Sci 9:413-23. 2012
    To determine the role of microRNA 21(miR-21) on left ventricular remodeling of rat heart with ischemia-reperfusion (I/R) injury and to investigate the underlying mechanism of miR-21 mediated myocardium protection.
  11. pmc Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
    Circ Cardiovasc Genet 4:614-9. 2011
    ..The current pilot study tested the hypotheses that plasma miRs could be reliably measured in post-MI patients and that there is a relationship between temporal changes in specific miRs and post-MI LV structural remodeling...
  12. ncbi Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling
    Atsushi Anzai
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circulation 125:1234-45. 2012
    ..We previously reported dendritic cell (DC) infiltration in the infarcted heart; however, the precise contribution of DC in postinfarction healing is unclear...
  13. pmc Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
    Ichiro Shiojima
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 115:2108-18. 2005
    ..Thus, both heart size and cardiac function are angiogenesis dependent, and disruption of coordinated tissue growth and angiogenesis in the heart contributes to the progression from adaptive cardiac hypertrophy to heart failure...
  14. pmc Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
    ..that Pn is critically involved in regulating the cardiac hypertrophic response, interstitial fibrosis, and ventricular remodeling following long-term pressure overload stimulation and myocardial infarction...
  15. pmc Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats
    Giselle C Melendez
    Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Hypertension 56:225-31. 2010
    ..These novel observations demonstrate that IL-6 induces a myocardial phenotype almost identical to that of the hypertensive heart, identifying IL-6 as potentially important in this remodeling process...
  16. pmc Impact of diabetes on postinfarction heart failure and left ventricular remodeling
    Helene von Bibra
    Klinic for Endocrinology, Diabetes and Vascular Medicine, Klinikum Bogenhausen, Städtische Klinikum München GmbH, Englschalkingerstrasse 77, 81925, Munchen, Germany
    Curr Heart Fail Rep 8:242-51. 2011
    ....
  17. pmc Post-infarct remodelling: contribution of wound healing and inflammation
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 81:474-81. 2009
    ..Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation...
  18. ncbi Regulatory T lymphocytes attenuate myocardial infarction-induced ventricular remodeling in mice
    Kazuaki Matsumoto
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 52:382-7. 2011
    ..We observed that adoptive Treg transfer could attenuate MI-induced cardiac remodeling through the IFN-gamma and Foxp3 alteration...
  19. ncbi MicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
    Circ Cardiovasc Genet 6:290-8. 2013
    ..MicroRNAs (miRNAs) regulate the expression of several genes involved in LV remodeling. Our aim was to identify miRNAs associated with LV remodeling after acute myocardial infarction...
  20. ncbi Inflammatory cytokines and postmyocardial infarction remodeling
    Min Nian
    Heart and Stroke RL Centre of Excellence, NCSB11 1266, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada
    Circ Res 94:1543-53. 2004
    ..Thus, the insightful modulation of cytokines through current and future therapies could promote improved healing and cardiac remodeling postmyocardial infarction...
  21. ncbi TGF-beta1 and angiotensin networking in cardiac remodeling
    Stephan Rosenkranz
    Klinik III fur Innere Medizin, Universitat zu Koln, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Cardiovasc Res 63:423-32. 2004
    ..Downstream mediators of cardiac Ang II/TGF-beta1 networking include Smad proteins, TGFbeta-activated kinase-1 (TAK1), and induction of hypertrophic responsiveness to beta-adrenergic stimulation in cardiac myocytes...
  22. ncbi Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice
    Shouji Matsushima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 113:1779-86. 2006
    ..We hypothesized that overexpression of the mitochondrial antioxidant, peroxiredoxin-3 (Prx-3), could attenuate this deleterious process...
  23. ncbi Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
    Zamaneh Kassiri
    Department of Physiology, University of Alberta, Edmonton, Canada
    Circ Heart Fail 2:446-55. 2009
    ..We hypothesized that ACE2 deficiency may compromise the cardiac response to myocardial infarction (MI)...
  24. ncbi Ventricular remodeling induced by retinoic acid supplementation in adult rats
    Sergio Alberto Rupp de Paiva
    Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, 18618 00 São Paulo, Brazil
    Am J Physiol Heart Circ Physiol 284:H2242-6. 2003
    ..Thus our study demonstrates that small physiological doses of RA induce ventricular remodeling resembling compensated volume-overload hypertrophy in rats.
  25. ncbi Role of oxidative stress in cardiac hypertrophy and remodeling
    Eiki Takimoto
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Hypertension 49:241-8. 2007
  26. ncbi Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction
    Christophe Dubois
    Department of Cardiovascular Diseases, Gasthuisberg University Hospitals Leuven, Leuven, Belgium
    J Am Coll Cardiol 55:2232-43. 2010
    ..We compared biological repair after acute myocardial infarction (AMI) with selected porcine progenitor cell populations...
  27. pmc Myocardial repair/remodelling following infarction: roles of local factors
    Yao Sun
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue, Box 20, Memphis, TN 38163, USA
    Cardiovasc Res 81:482-90. 2009
    ..This review will discuss the role of oxidative stress and locally produced angiotensin II in the pathogenesis of myocardial repair/remodelling after MI...
  28. ncbi Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure
    Antonio Abbate
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    J Am Coll Cardiol 41:753-60. 2003
    ....
  29. pmc IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR
    Prasanna Krishnamurthy
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA
    Circ Res 104:e9-18. 2009
    ....
  30. ncbi Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state
    Mei Sun
    The Heart and Stroke Richard Lewar Centre of Excellence and Toronto General University Health Network, Toronto, Ontario, Canada
    Circulation 115:1398-407. 2007
    ..accompanied by cardiac myocyte apoptosis, hypertrophy, and inflammatory/fibrogenic responses that lead to ventricular remodeling and heart failure...
  31. ncbi NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure
    Colin E Murdoch
    Department of Cardiology, Cardiovascular Division, King s College London School of Medicine, Bessemer Road, London SE5 9PJ, United Kingdom
    Cardiovasc Res 71:208-15. 2006
    ....
  32. ncbi Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats
    Anneleen Daniels
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Eur J Heart Fail 14:193-201. 2012
    ..Here, we investigated the severity of diabetic cardiomyopathy and myocardial remodelling in aged Zucker diabetic fatty (ZDF) rats...
  33. ncbi Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms
    Cecilia Linde
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    J Am Coll Cardiol 52:1834-43. 2008
    ....
  34. ncbi Inhibition of endostatin/collagen XVIII deteriorates left ventricular remodeling and heart failure in rat myocardial infarction model
    Kazuya Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 74:109-19. 2010
    ..In the present study the role of endostatin in left ventricular (LV) remodeling and heart failure was tested in a rat MI model...
  35. ncbi Regulatory T cells ameliorate cardiac remodeling after myocardial infarction
    Ting Ting Tang
    Laboratory of Cardiovascular Immunology, Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430022, China
    Basic Res Cardiol 107:232. 2012
    Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI)...
  36. ncbi Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure
    Dan Sorescu
    Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Congest Heart Fail 8:132-40. 2002
    ..Future studies are necessary to identify the sources, mechanisms of activation of NAD(P)H oxidases, and downstream signaling targets implicated in the progression of chronic heart failure...
  37. ncbi New targets to treat the structural remodeling of the myocardium
    Arantxa Gonzalez
    Division of Cardiovascular Sciences, Centre of Applied Medical Research, University of Navarra, Pamplona, Spain
    J Am Coll Cardiol 58:1833-43. 2011
    ..In this paper, we will examine recent insights from experimental and pilot clinical studies that have provided new targets for interventions to prevent or reverse inflammation, alterations of collagen matrix, and cardiomyocyte death...
  38. ncbi Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice
    M Scherrer-Crosbie
    Cardiology Division, Cardiovascular Research Center, Department of Medicine, Boston, Massachusetts, USA
    Circulation 104:1286-91. 2001
    ..Conclusions- These results suggest that the presence of NOS3 limits LV dysfunction and remodeling in a murine model of MI by an afterload-independent mechanism, in part by decreasing myocyte hypertrophy in the remote myocardium...
  39. ncbi Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy
    Yoshinori Mano
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ J 75:1717-27. 2011
    ..However, the effect of CRP on heart failure has not been elucidated. The effect of human CRP on cardiac dysfunction induced by diabetes mellitus (DM) using human CRP-overexpressing transgenic mice (CRP-Tg) was examined...
  40. ncbi Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study
    E Wu
    Feinberg Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 201 East Huron, Galter 10 240, Chicago, IL 60611 2908, USA
    Heart 94:730-6. 2008
    ..We sought to assess the relative impact of infarct size, EF and ESVI on clinical outcomes and left ventricular (LV) remodelling...
  41. pmc A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction left ventricular remodeling
    Qiang Xiong
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 5545, USA
    Stem Cells 29:367-75. 2011
    ..These findings demonstrate a promising therapeutic potential of using these hESC-derived vascular cell types and the mode of patch delivery...
  42. ncbi Early onset and progression of left ventricular remodeling after alcohol septal ablation in hypertrophic obstructive cardiomyopathy
    Willem G van Dockum
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 111:2503-8. 2005
    ..pressure gradient in patients with hypertrophic obstructive cardiomyopathy (HOCM), which leads to left ventricular remodeling. We sought to describe the early to midterm changes and modulating factors of the remodeling process using ..
  43. ncbi Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease
    Brian D Powell
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 98:116-20. 2006
    ..22, p <0.001). Obesity was associated with ventricular remodeling, which may normalize wall stress while increasing stroke volume to match metabolic demand...
  44. ncbi Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction
    Nathan Mewton
    Hospices Civils de Lyon, Universite Claude Bernard Lyon, Lyon, France
    J Am Coll Cardiol 55:1200-5. 2010
    ..This study examined the effect of a single dose of cyclosporine administered at the time of reperfusion on left ventricular (LV) remodeling and function by cardiac magnetic resonance 5 days and 6 months after myocardial infarction...
  45. pmc Timing of cardiovascular MR imaging after acute myocardial infarction: effect on estimates of infarct characteristics and prediction of late ventricular remodeling
    Adam N Mather
    Multidisciplinary Cardiovascular Research Centre, Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Jubilee Wing, Leeds General Infirmary, Leeds LS1 3EX, England
    Radiology 261:116-26. 2011
    ....
  46. ncbi Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction
    Sebastian J Buss
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Am Coll Cardiol 54:2435-46. 2009
    ..In this study we investigated whether inhibition of "mammalian target of rapamycin" (mTOR) attenuates left ventricular (LV) remodeling after MI...
  47. ncbi Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction
    Shuo Tsan Lee
    Cedars Sinai Heart Institute, Los Angeles, California 90048, USA
    J Am Coll Cardiol 57:455-65. 2011
    ....
  48. ncbi Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction
    Geeta D Thakker
    Dept of Medicine, Baylor College of Medicine, 6565 Fannin, M S A 601, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 291:H2504-14. 2006
    ....
  49. ncbi Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy
    G Christian Baldeviano
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 106:1646-55. 2010
    ..CD4(+) T helper (Th)17 cells have been implicated in the pathogenesis of autoimmune diseases, but the role of Th17-produced cytokines during inflammation-induced cardiac remodeling has not been previously studied...
  50. pmc Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study
    Dominic Kelly
    Department of Vascular Surgery, St George s Hospital Medical School, London, UK
    Eur Heart J 28:711-8. 2007
    ....
  51. ncbi Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?
    Bodh I Jugdutt
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 108:1395-403. 2003
  52. ncbi Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction
    Shunji Hayashidani
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 285:H1229-35. 2003
    ..The inhibition of MMP-2 activation may therefore be a potentially useful therapeutic strategy to manage post-MI hearts...
  53. ncbi Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
    Carola Doerries
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Hannover, Germany
    Circ Res 100:894-903. 2007
    ..The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI...
  54. ncbi Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction
    Yee H Looi
    Department of Cardiology, King s College London School of Medicine, James Black Centre, 125 Coldharbour Ln, London SE5 9NU, United Kingdom
    Hypertension 51:319-25. 2008
    ..These data suggest that the Nox2-containing reduced nicotinamide-adenine dinucleotide phosphate oxidase contributes significantly to the processes underlying adverse cardiac remodeling and contractile dysfunction post-MI...
  55. ncbi Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences
    Brett Burstein
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circulation 117:1630-41. 2008
    ..In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined...
  56. ncbi Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction
    Leo Timmers
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 102:257-64. 2008
    ..TLR4 may therefore constitute a novel target in the treatment of ischemic heart failure...
  57. ncbi Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction
    Liang Ding
    Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
    Circulation 120:764-73. 2009
    ..Left ventricular (LV) remodeling is associated with the development of heart failure after myocardial infarction. Here we investigated whether integrin-linked kinase (ILK) may regulate LV remodeling and function after myocardial infarction...
  58. pmc Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice
    Machteld J van Amerongen
    University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Pathol 170:818-29. 2007
    ..Based on these findings, we propose that increasing macrophage numbers early after myocardial infarction could be a clinically relevant option to promote myocardial wound healing and subsequently to reduce remodeling and heart failure...
  59. ncbi Healing after myocardial infarction
    Georg Ertl
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 66:22-32. 2005
    ....
  60. pmc Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling
    Gerald W Dorn
    Center for Pharmacogenomics and Cardiovascular Division, Department of Internal Medicine, Washington University, 660 S Euclid Ave, Campus Box 8086, St Louis, MO 63110, USA
    Cardiovasc Res 81:465-73. 2009
    ..The major focus of this review is on apoptosis in heart failure, with a discussion of molecular cross-talk between apoptosis, autophagy, and programmed necrosis...
  61. ncbi Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling
    Carson S Webb
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 114:1020-7. 2006
    ..We tested the hypothesis that a specific plasma MMP/TIMP profile would emerge after MI and be associated with the degree of LV dilation...
  62. ncbi Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities
    Jason J Gajarsa
    Division of Cardiology, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Heart Fail Rev 16:13-21. 2011
    ....
  63. ncbi Mitochondrial oxidative stress and dysfunction in myocardial remodelling
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Cardiovasc Res 81:449-56. 2009
    ..Inhibition of oxidative stress and mtDNA damage could be novel and effective treatment strategies for heart failure...
  64. ncbi Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction
    Marina R Bergman
    Department of Medicine, San Francisco Department of Veterans Affairs Medical Center University of California, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 292:H1847-60. 2007
    Although enhanced cardiac matrix metalloproteinase (MMP)-2 synthesis has been associated with ventricular remodeling and failure, whether MMP-2 expression is a direct mediator of this process is unknown...
  65. ncbi Microvascular obstruction is a major determinant of infarct healing and subsequent left ventricular remodelling following primary percutaneous coronary intervention
    Stein Ørn
    Division of Cardiology, Stavanger University Hospital, PO 8400, Stavanger 4068, Norway
    Eur Heart J 30:1978-85. 2009
    ..We studied the time-dependent relationships between microvascular obstruction (MO), infarct size, and left ventricular (LV) remodelling after acute myocardial infarction (MI)...
  66. pmc Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion
    Hang Yin
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425 2211, USA
    Life Sci 82:156-65. 2008
    ..kinin B2 receptor and NO formation improves cardiac function, prevents inflammation and limits left ventricular remodeling after myocardial I/R by suppression of oxidative stress, TGF-beta1/Smad2 and JNK/p38MAPK signaling ..
  67. ncbi beta-carotene attenuates the paradoxical effect of tobacco smoke on the mortality of rats after experimental myocardial infarction
    Sergio A R Paiva
    Departamento de Clinica Medica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista UNESP, Botucatu, Brazil
    J Nutr 135:2109-13. 2005
    ..to tobacco smoke (ETS) in rats that were or were not supplemented with dietary beta-carotene (BC), on ventricular remodeling and survival after myocardial infarction (MI)...
  68. pmc Resveratrol treatment reduces cardiac progenitor cell dysfunction and prevents morpho-functional ventricular remodeling in type-1 diabetic rats
    Francesca Delucchi
    Dipartimento Biologia Evolutiva e Funzionale, Universita di Parma, Parma, Italy
    PLoS ONE 7:e39836. 2012
    ..animals, cardiac function was maintained during the first 3 weeks of hyperglycemia, although a definite ventricular remodeling was already present, mainly characterized by a marked loss of CSPCs and adult cardiac cells...
  69. ncbi Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction
    Toyoharu Oba
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Japan
    J Am Coll Cardiol 59:838-52. 2012
    ....
  70. ncbi Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction
    Shu Kasama
    Department of Cardiovascular Medicine, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 0034, Japan
    Eur Heart J 29:1485-94. 2008
    ..ANP has a variety of cardioprotective effects and is considered to be a very promising adjunct drug for the reperfusion therapy in patients with AMI...
  71. ncbi Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice
    M Y Maslov
    Carnegie 584, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287 6568, USA
    Am J Physiol Heart Circ Physiol 292:H387-91. 2007
    ..These data suggest that abnormal energetics due to pressure overload predict subsequent LV remodeling and dysfunction...
  72. ncbi Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice
    Tsuyoshi Hattori
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circulation 109:2234-9. 2004
    ..Because proinflammatory cytokines play a critical role in left ventricular (LV) remodeling after myocardial infarction (MI), we examined whether long-term blockade of Rho-kinase suppresses LV remodeling in a mouse model of MI in vivo...
  73. ncbi Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure
    Antonio Cittadini
    Department of Internal Medicine and Cardiovascular Sciences, University Federico II, Via Sergio Pansini 5, Naples, Italy
    Eur J Heart Fail 13:1264-74. 2011
    ..Our aim was to investigate the effects of sequential release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) from biodegradable gelatin microspheres in experimental heart failure...
  74. ncbi Obstructive sleep apnea: effects of continuous positive airway pressure on cardiac remodeling as assessed by cardiac biomarkers, echocardiography, and cardiac MRI
    Jane Colish
    Department of Internal Medicine, St Boniface General Hospital, Winnipeg, Manitoba, Canada
    Chest 141:674-81. 2012
    ....
  75. ncbi Relaxin remodels fibrotic healing following myocardial infarction
    Chrishan S Samuel
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    Lab Invest 91:675-90. 2011
    ..remains unclear whether it is feasible and safe to remodel fibrotic healing post-MI without compromising ventricular remodeling and dysfunction...
  76. ncbi Early measurements of plasma matrix metalloproteinase-2 predict infarct size and ventricular dysfunction in ST-elevation myocardial infarction
    Lennart Nilsson
    Department of Cardiology, University Hospital, Linköping S 58185, Sweden
    Heart 98:31-6. 2012
    ..The activation of matrix metalloproteinases (MMPs) is suggested to be a key event in this process...
  77. pmc In search of new therapeutic targets and strategies for heart failure: recent advances in basic science
    Ajay M Shah
    King s College London British Heart Foundation Centre of Excellence, London, UK
    Lancet 378:704-12. 2011
    ....
  78. ncbi Polymorphisms of the beta adrenergic receptor predict left ventricular remodeling following acute myocardial infarction
    Rhondalyn C McLean
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Cardiovasc Drugs Ther 25:251-8. 2011
    ..The underlying mechanism may be due to differences in left ventricular remodeling. This study was undertaken to explore the relationship between LV remodeling after myocardial infarction ..
  79. ncbi Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment
    Marvin A Konstam
    Cardiovascular Center, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 4:98-108. 2011
    b>Ventricular remodeling, first described in animal models of left ventricular (LV) stress and injury, occurs progressively in untreated patients after large myocardial infarction and in those with dilated forms of cardiomyopathy...
  80. ncbi Relation of plasma brain natriuretic peptide levels on admission for ST-elevation myocardial infarction to left ventricular end-diastolic volume six months later measured by both echocardiography and cardiac magnetic resonance
    Ana García-Alvarez
    Thorax Clinic Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Cardiol 104:878-82. 2009
    ..The early determination of plasma BNP upon admission for STEMI could be helpful in identifying patients at higher risk for LV dilatation, in whom aggressive management is warranted...
  81. pmc A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling
    David Simpson
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Stem Cells 25:2350-7. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  82. ncbi Three-dimensional shape analysis of right ventricular remodeling in repaired tetralogy of Fallot
    Florence H Sheehan
    University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:107-13. 2008
    ..005). In conclusion, the right ventricle remodels in several directions rather than following a shape continuum. Characterization of RV remodeling from 3-dimensional reconstructions provides novel insights...
  83. pmc Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5
    Manling Zhang
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 56:2021-30. 2010
    ....
  84. ncbi Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation
    Cameron Donaldson
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Circ Res 104:265-75, 11p following 275. 2009
    ..These data support that E2 reduces pressure overload induced hypertrophy by an ER-dependent mechanism that increases CnA degradation, unveiling a novel mechanism by which E2 and ERs regulate pathological LV and cardiomyocyte growth...
  85. pmc Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure
    Qing Lou
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    Circulation 123:1881-90. 2011
    ..The objective of this article was to study functional remodeling of excitation-contraction coupling and calcium handling in failing and nonfailing human hearts...
  86. ncbi The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart
    Thomas Brade
    Department of Biochemistry and Molecular Biology, University of Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    Cardiovasc Res 72:198-209. 2006
    ..In this review, we will focus on the functions of the Wnt family of growth factors in normal cardiac development and in tissue remodelling in the mature heart under pathological conditions...
  87. ncbi Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction
    Toshiyuki Takahashi
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 299:H1795-804. 2010
    ..The deleterious effect of CRP on post-MI LV remodeling may be associated with increased apoptotic rates, macrophage infiltration, MCP-1 expression, and MMP-9 activity in the border zone...
  88. ncbi Asialoerythropoietin, a nonerythropoietic derivative of erythropoietin, displays broad anti-heart failure activity
    Toshiaki Takeyama
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Circ Heart Fail 5:274-85. 2012
    ..We investigated the effects of asialoerythropoietin (asialoEPO), a nonerythrogenic erythropoietin derivative, on 3 murine models of heart failure with different etiologies...
  89. ncbi Cathepsin-L contributes to cardiac repair and remodelling post-infarction
    Mei Sun
    Division of Cardiology, Heart and Stroke Richard Lewar Centre of Excellence, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada
    Cardiovasc Res 89:374-83. 2011
    ..Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction...
  90. ncbi FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model
    Tobias G Schips
    Institute of Physiological Chemistry, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Cardiovasc Res 91:587-97. 2011
    ..We wanted to study FoxO3 function in the adult heart in vivo by expressing a constitutively active mutant of FoxO3 in transgenic mice...
  91. pmc Left ventricular mass and ventricular remodeling among Hispanic subgroups compared with non-Hispanic blacks and whites: MESA (Multi-ethnic Study of Atherosclerosis)
    Carlos J Rodriguez
    Department of Medicine, Mailman School of Public Health, Columbia University, New York, New York, USA
    J Am Coll Cardiol 55:234-42. 2010
    ....
  92. ncbi Changes of matrix metalloproteinase-9 level is associated with left ventricular remodeling following acute myocardial infarction among patients treated with trandolapril, valsartan or both
    Sakiko Miyazaki
    Department of Cardiology, Juntendo Shizuoka Hospital, Shizuoka, Japan
    Circ J 74:1158-64. 2010
    ..The presence of any differences in LV remodeling and MMP-9 levels across the groups was also investigated...
  93. ncbi Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications
    Leonardo Bolognese
    Division of Cardiology, S Donato Hospital, Arezzo, Italy
    Circulation 106:2351-7. 2002
    ..The prevalence, course, and prognostic value of LV remodeling after primary PTCA are still to be clarified...
  94. ncbi Invasive acute hemodynamic response to guide left ventricular lead implantation predicts chronic remodeling in patients undergoing cardiac resynchronization therapy
    Simon G Duckett
    Department of Imaging Sciences, The Rayne Institute, Kings College London, London, United Kingdom
    J Am Coll Cardiol 58:1128-36. 2011
    ..We evaluated the relationship between acute hemodynamic response (AHR) and reverse remodeling (RR) in cardiac resynchronization therapy (CRT)...
  95. ncbi Metoprolol reverses left ventricular remodeling in patients with asymptomatic systolic dysfunction: the REversal of VEntricular Remodeling with Toprol-XL (REVERT) trial
    Wilson S Colucci
    Cardiovascular Medicine, Boston University Medical Center, 88 E Newton St, Boston, MA 02118, USA
    Circulation 116:49-56. 2007
    ..We investigated whether beta-blocker therapy ameliorates left ventricular remodeling in asymptomatic patients with left ventricular systolic dysfunction.
  96. pmc Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats
    Samson Mathews Samuel
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    Circulation 121:1244-55. 2010
    ..Trx1). Various studies have linked diabetes-mediated impairment of angiogenesis to dysfunctional antioxidant systems in which thioredoxin-1 plays a central role...
  97. ncbi C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction
    Stein Ørn
    Division of Cardiology, Stavanger University Hospital, PO 8400, 4068 Stavanger, Norway
    Eur Heart J 30:1180-6. 2009
    ....
  98. ncbi Cardiac remodeling and heart failure after a first anterior myocardial infarction in patients with diabetes mellitus
    Nicolas Lamblin
    INSERM U744, Institut Pasteur de Lille, Universite de Lille, Lille, France
    J Cardiovasc Med (Hagerstown) 13:353-9. 2012
    ..The mechanisms underlying the higher risk of heart failure after myocardial infarction (MI) in diabetic patients remain incompletely understood. Our aim was to investigate cardiac remodeling after MI according to diabetic status...
  99. ncbi Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: from contractility to remodeling
    Joanna Hammond
    Pole of Pharmacology and Therapeutics FATH, Institut de Recherche Expérimentale et Clinique IREC, Universite Catholique de Louvain UCL, 52 Avenue Mounier, 1200 Brussels, EU, Belgium
    J Mol Cell Cardiol 52:330-40. 2012
    ..Thus, enhancing cardiac myocyte cGMP signaling represents a promising therapeutic target for treatment of cardiovascular disease. This article is part of a Special Issue entitled "Local Signaling in Myocytes."..
  100. ncbi The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling
    Xiaohong Wang
    Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, 55455, USA
    Stem Cells 24:1779-88. 2006
    ..Sca-1(+)/CD31(-) cells may hold therapeutic possibilities with regard to the treatment of ischemic heart disease...
  101. ncbi Effect of left ventricular scar size, location, and transmurality on left ventricular remodeling with healed myocardial infarction
    Stein Orn
    University of Bergen, Stavanger University Hospital, Stavanger, Norway
    Am J Cardiol 99:1109-14. 2007
    ..In conclusion, in the studied cohort, there was a linear relation between scar size and ejection fraction and LV volumes. This relation was independent of scar location and transmurality...

Research Grants67

  1. The role of IKK beta in cardiomyocytes at baseline and following stress
    MATTHEW PETER COGGINS; Fiscal Year: 2013
    ..In the heart, while it is known that NF-kB is involved in hypertrophy, ventricular remodeling, and ischemic injury, its precise role remains incompletely defined...
  2. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..factors in cardiac disease can be an effective means of salvaging myocardium and preventing adverse ventricular remodeling. In published and preliminary experiments we have identified two closely related BH3-only proteins, Bnip3 (..
  3. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    ..or stress such as ischemia or pressure-overload with cardiac hypertrophy occurring first, followed by ventricular remodeling and a loss of contractile function and [unreadable]-adrenergic receptor ([unreadable]AR) -mediated ..
  4. Oxygen versus PAP for treatment of sleep apnea in chronic heart failure
    Henry Klar Yaggi; Fiscal Year: 2013
    ..of isoprostanes (a marker of oxidative stress), aminoterminal propeptide of type III collagen (a marker of ventricular remodeling), B-type natriuretic peptide, and plasma levels of several markers of inflammation...
  5. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..States and is associated with a variety of clinical abnormalities, including congestive heart failure, ventricular remodeling, ischemia, ion homeostasis, arrhythmias, and sudden cardiac death...
  6. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    ..by applicant): Objectives and Specific Aims Myocardial ischemia and infarction with resultant adverse ventricular remodeling and heart failure form an increasingly prevalent global health problem for which medical and surgical ..
  7. Cardioprotective Signaling following Phosphodiesterase-5 Inhibition
    Rakesh C Kukreja; Fiscal Year: 2012
    ..In addition, our investigations will open up another innovative gene silencing option to treat AMI and ventricular remodeling in patients.
  8. Stem Cells For Myocardial Repair: A Large Bore Magnet Study
    Jianyi Zhang; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Post-infarction left ventricular remodeling including hypertrophy and chamber dilation occurs to compensate for loss of contractile myocardium...
  9. Development of an In Vivo Stem Cell Tracking Method Using Ultrasound Imaging
    Flordeliza S Villanueva; Fiscal Year: 2010
    ..Congestive heart failure resulting from myocardial infarction and subsequent adverse left ventricular remodeling is a major cause of morbidity, mortality and health care spending in Western nations...
  10. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..myocardial infarction and reperfusion has been implicated as a crucial factor, which ultimately leads to ventricular remodeling, heart failure, and cardiovascular death...
  11. Inhibition of GRK2 to Prevent Ventricular Remodeling and Heart Failure After CABG
    Shahab A Akhter; Fiscal Year: 2013
    ..Adverse or maladaptive ventricular remodeling can continue following revascularization and appears to be an important risk factor for poor long-term ..
  12. Fatty Acids and Heart Failure in the Physicians'Health Study
    Luc Djousse; Fiscal Year: 2013
    ..In addition, n-3 fatty acids have been shown to attenuate ventricular remodeling and dysfunction induced by pressure overload in animal models...
  13. The conditional GPR30 knockout mouse: a model of female-specific cardiac aging
    Leanne Groban; Fiscal Year: 2013
    ..While evidence suggests that estrogen may protect the premenopausal heart from hypertension and ventricular remodeling, the mechanisms involved are not understood...
  14. Mitochondrial Matrix Metalloproteinase-2 and Cardiac Injury
    David H Lovett; Fiscal Year: 2013
    ..Clinically, MMP-2 directly contributes to progressive ventricular remodeling and congestive heart failure and a further understanding of the role(s) of this enzyme is critically ..
  15. Nuclear magnetic Tirho relaxation in acute and chronic myocardial infarctions
    Walter R T Witschey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cardiac left ventricular remodeling is responsible for over 250,000 heart failure deaths each year in the United States...
  16. Disease Mechanisms in ARVC
    Jeffrey E Saffitz; Fiscal Year: 2013
    ..which occur early in the natural history of the disease and often precede the development of significant ventricular remodeling or contractile dysfunction...
  17. Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies
    Jil C Tardiff; Fiscal Year: 2013
    ..many patients do not develop the "classic" left ventricular hypertrophy, but instead undergo aggressive ventricular remodeling and experience a significant frequency of sudden cardiac death...
  18. Multi-parameter CMR of post-MI Left Ventricular Remodeling in Gene Modified Mice
    Brent A French; Fiscal Year: 2013
    ....
  19. Percutaneous deliverable biomaterial for treating myocardial infarction
    Adam M Kinsey; Fiscal Year: 2011
    ..delivery and 2) Determine the influence of VentriGelTM on post-myocardial infarction negative left ventricular remodeling, cardiac function, and potential for arrhythmias in a porcine myocardial infarction model...
  20. Ventricular Remodeling in the Adapted Heart
    Nilanjana Maulik; Fiscal Year: 2012
    ..VEGF signaling which might play significant role in myocardial angiogenesis leading to the inhibition of ventricular remodeling. Ereg has angiogenic potential, which may contribute to de novo development of vessels by vasculogenesis ..
  21. Activation of sirtuins to prevent adverse cardiac remodeling after CABG
    Mahesh P Gupta; Fiscal Year: 2013
    ..by coronary artery bypass grafting (CABG) patients with MI (myocardial infarction) often develop adverse ventricular remodeling in the remote myocardium which generates complications leading to HF...
  22. A Pilot Clinical Study in Acute STEMI
    Weizhong Cai; Fiscal Year: 2011
    ..arrhythmias, long-term prognosis is dependent on the amount of myocardium that is lost, and the outcome of ventricular remodeling. Scatter factor / hepatocyte growth factor (SF/HGF) is an endogenous cell survival factor that exerts both ..
  23. Dystrophin Function in Aging Heart
    JOSEPH MARK METZGER; Fiscal Year: 2013
    ..Hypotheses: systemic micro-dystrophin gene transfer will prevent aging-dependent ventricular remodeling and confer long-term (year) protection during in vivo cardiac stress testing in vivo;micro- dystrophin ..
  24. Computational Tools to Describe Cardiac Post-MI Structure and Function Remodeling
    Siamak Ardekani; Fiscal Year: 2012
    ..For example, in patients with coronary artery disease and left ventricular dysfunction, ventricular remodeling results in a gradual increase of ventricular end-diastolic and end- systolic volumes, wall thinning, ..
  25. Surgery to Prevent Postinfarction Ventricular Remodeling
    Robert C Gorman; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This project seeks to determine the mechanism of post infarction left ventricular remodeling. The contribution of infarct expansion and ischemic mitral regurgitation will be studied...
  26. Extracellular matrix hydrogels for treating ischemia
    Karen L Christman; Fiscal Year: 2013
    ..of an injectable acellular myocardial matrix hydrogen alone on post-myocardial infarction negative left ventricular remodeling, endogenous cardiomyocyte survival, cell infiltration, and cardiac function, 2) To determine the influence ..
  27. Regulation and Function of Tissue Kallikrein
    Julie Chao; Fiscal Year: 2012
    ..1) determine the effect and signaling mechanisms of tissue kallikrein on angiogenesis, arteriogenesis and ventricular remodeling in rats after myocardial infarction, and on migration, growth and capillary tube formation in endothelial ..
  28. Conduction System Remodeling After Myocardial Infarction
    TERRENCE XAVIER O'BRIEN; Fiscal Year: 2011
    ..with the Cx40EGFP/+ transgenic line and controls to determine changes in the PCS phenotype during the ventricular remodeling post-MI...
  29. RGS Regulation of Cardiac Signaling and Hypertrophy
    Ulrike Mende; Fiscal Year: 2010
    ..essential) compensation, persistent hypertrophy in response to excess hemodynamic workload often leads to ventricular remodeling with functional decompensation and development of overt heart failure...
  30. The Role of Macrophage-Derived MMP-9 in LV Remodeling
    Merry L Lindsey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This is an A2 resubmission of a renewal application to study left ventricular remodeling following myocardial infarction (MI)...
  31. The Effects of Aging on Apoptosis Following Myocardial Infarction.
    ANDREW JOHN BOYLE; Fiscal Year: 2013
    ..called programmed cell death, of cardiomyocytes following Ml is a crucial aspect of the process of left ventricular remodeling that leads to heart failure...
  32. Inflammatory Proteases and Diabetic Cardiomyopathy
    Khadija Rafiq; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetic cardiomyopathy (DCM) is characterized by left ventricular remodeling and dysfunction independent of atherosclerosis, coronary heart disease, or hypertension...
  33. Cellular Cardiomyoplasty for Chronic Heart Failure
    Joshua M Hare; Fiscal Year: 2013
    ..this award to develop sophisticated porcine models of ischemic cardiomyopathy characterized by progressive ventricular remodeling. Using this model we have tested several strategies for cell-based therapeutics, gleaned major mechanistic ..
  34. Deciphering Myofilament Modifications in Ischemic Cardiomyopathy
    Ying Ge; Fiscal Year: 2013
    ..and understand how these alterations act in concert to modulate maladaptive signaling during post-MI left ventricular remodeling to failure...
  35. Mathematical Modeling of Matrix Metalloproteinase-9 Driven Left Ventricular Remod
    Yufang Jin; Fiscal Year: 2010
    ..The objective of this study is to establish the mathematical model to predict MMP-9 driven left ventricular remodeling post-MI...
  36. Mitochondrial dynamics and cardiac remodeling
    Kenneth Walsh; Fiscal Year: 2013
    ..myocyte-specific ablation of both Mfn1 and Mfn2 leads to a greater number of fragmented mitochondria, left ventricular remodeling and systolic dysfunction, and increased mortality during the transition from fetal to post-natal life...
  37. VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERY
    JULIUS MATTEO GUCCIONE; Fiscal Year: 2013
    ..abstract_text> ..
  38. Mitochondrial Permeability Transition as a Target for Cardioprotection in Heart F
    Sabzali Javadov; Fiscal Year: 2013
    ..Mitochondrial dysfunction is central to the loss of contractile function during ventricular remodeling/heart failure that are thought to be induced as a result of inactivation of cell signaling molecules, AMP-..
  39. Targeting Wave Reflections in Heart Failure with Preserved Ejection Fraction
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2013
    ..observational studies that link arterial wave reflections to abnormal left ventricular relaxation, left ventricular remodeling (hypertrophy) and HF risk, we propose a pilot randomized double-blind controlled clinical trial designed ..
  40. Heart Repair through Reprogramming of Cardiac Cell Fate
    Eric N Olson; Fiscal Year: 2013
    ..cardiac gene expression in vivo, leading to improvement of cardiac function and reduction of adverse ventricular remodeling following MI in mice...
  41. ANISOTROPY IN HEALING MYOCARDIAL SCAR TISSUE
    Jeffrey W Holmes; Fiscal Year: 2010
    ..critical determinant of left ventricular function, infarct expansion, aneurysm formation and rupture, and ventricular remodeling. Until recently, the only therapeutic options for addressing these consequences were pharmacologic...
  42. Prognostic Utility of Absolute Coronary Microvascular Function by PET/CT
    Sharmila Dorbala; Fiscal Year: 2013
    ..of coronary microvascular function to predict major adverse cardiac events of sudden death, risk of left ventricular remodeling/heart failure, and risks from progression to obstructive epicardlal CAD...
  43. G-PROTEIN-DEPENDENT AND -INDEPENDENT KINASE SIGNALING IN CARDIAC HYPERTROPHY
    Gerald W Dorn; Fiscal Year: 2013
    ..that activation of GRKs and PKCs alters cardiomyocyte gene expression, cardiac contractility and ventricular remodeling in response to hemodynamic stress...
  44. Influence of the Cardiomyocyte Circadian Clock on Cardiac Hypertrophy
    MARTIN ELLIOT YOUNG; Fiscal Year: 2013
    ..completion of the following specific aims (SA): SA1 - Determine whether time-of-day-dependent pathologic ventricular remodeling in response to isoproterenol is mediated by the cardiomyocyte circadian clock;and SA2 - Elucidate whether ..
  45. Isolated Left Ventricular Restraint Therapy for Heart Failure
    Michael H Kwon; Fiscal Year: 2011
    ..have shown that this device can produce more robust improvement in heart function and reversal of left ventricular remodeling in comparison to the original non-adjustable prosthetic wraps...
  46. Imaging Stem Cell Grafted in the Infarcted Myocardium
    Rong Zhou; Fiscal Year: 2009
    ..because most studies failed to account for the variations in the initial infarct size and the extent of ventricular remodeling on the therapeutic outcome;the fate (survival and differentiation status) of the grafted cells is not ..
  47. 3D MRI-Based Modeling for Computer-Aided Right Ventricle Remodeling Surgery
    Dalin Tang; Fiscal Year: 2013
    ..A multidisciplinary group of experienced investigators in congenital cardiac surgery, cardiology and computational mathematics will conduct this project. ..
  48. TGF-beta1 activity in the aortic valve
    WILLIAM D MERRYMAN; Fiscal Year: 2013
    ..As valve disease prevalence grows with age, and due to our increasing lifespan, understanding these mechanisms and how they may be prevented are very important...
  49. MRI in mouse models of heart disease
    Frederick H Epstein; Fiscal Year: 2013
    ..elucidate the roles of various receptors and enzymes in normal cardiac function and in post-infarct left-ventricular remodeling. Next, we propose to focus on imaging to elucidate mechanisms underlying coronary microvascular ..
  50. The Role of Neuregulin in Human Cardiac Remodeling and Heart Failure
    Bonnie Ky; Fiscal Year: 2013
    ..this scientific proposal is to determine the clinical relevance of circulating neuregulin as it relates to ventricular remodeling and risk of adverse clinical outcomes across a broad range of human cardiac remodeling phenotypes...
  51. Myocardial Structure, Function, and Remodeling in Mitral Regurgitation
    Daniel B Ennis; Fiscal Year: 2010
    ..A refinement in our understanding of the pathogenesis of ventricular remodeling in mitral regurgitation is clearly needed to improve clinical outcomes...
  52. CARDIAC ENERGY METABOLISM IN HEART FAILURE
    Hani N Sabbah; Fiscal Year: 2013
    ..but there is strong evidence that energy metabolism can effect contractile function and progressive left ventricular remodeling. This translational research project uses sophisticated animal models of HF to evaluate novel mechanisms ..
  53. Effects of Aging on LV Geometry and MMP-9 Expression Level
    Yufang Jin; Fiscal Year: 2011
    ..Age-related left ventricular remodeling is associated with increased deposition of cardiac extracellular matrix, and matrix metalloproteinase-9 ..
  54. miR-152: A Novel Regulator of Diabetic Cardiomyopathy
    Ioannis Karakikes; Fiscal Year: 2013
    ..will build on these findings to test the hypothesis that miR-152 regulates cardiac contractility and ventricular remodeling in vivo...
  55. Notch function in myocardial development and homeostasis
    Mark Mercola; Fiscal Year: 2010
    ..Our data indicate that late gestation to adult conditional myocardial KO of CSL causes ventricular remodeling by 3 months of age...
  56. Right ventricular restraint therapy for right heart failure
    Marisa Cevasco; Fiscal Year: 2011
    ..has been shown to reduce myocardial wall stress and oxygen consumption and reverse the pathological left ventricular remodeling associated with left heart failure...
  57. Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
    NATHAN CLAUDE GIANNESCHI; Fiscal Year: 2013
    ..is therefore to develop autonomously assembling nanomaterial scaffolds, which can be delivered via IV injection, target the area of acute MI, prevent and/or slow negative left ventricular remodeling, and improve cardiac function post-MI.
  58. Bone Marrow Angioblasts for Myocardial Vasculogenesis
    Silviu Itescu; Fiscal Year: 2006
    Congestive heart failure remains a major public health problem, and is frequently the result of left ventricular remodeling after myocardial infarction...
  59. SURGERY FOR ACUTE MYOCARDIAL INFARCTION
    L Edmunds; Fiscal Year: 2000
    ..based on the therapeutically attractive hypothesis that medical/surgical interventions can favorably alter ventricular remodeling after an ischemic event such that left ventricular failure/dilatation, mitral regurgitation, and left ..
  60. Pathophysiology of Heart Failure with a Normal Ejection Fraction in the Elderly
    Mathew S Maurer; Fiscal Year: 2010
    ..may be an important, modifiable contributor to exercise intolerance in elderly HFNEF patients, abnormal ventricular remodeling and impaired overall health status and quality of life...
  61. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002
    ..in structural protein content have been postulated to contribute to myocyte slippage, wall thinning, and ventricular remodeling in heart failure...
  62. SCCOR in Cardiac Dysfunction and Disease
    Daniel Kelly; Fiscal Year: 2009
    ..humans (Project 2);delineate the contribution of increased myocardial fatty acid metabolism to pathologic ventricular remodeling in patients with diabetes mellitus following coronary ischemia/reperfusion or myocardial infarction using ..
  63. MYOCARDIAL ENERGY METABOLISM IN THE DYSFUNCTIONAL LV
    Jianyi Zhang; Fiscal Year: 2003
    ..This study will be carried out in a pig model of post-infarction left ventricular remodeling in which a significant portion of the infarcted animals develop CHF...
  64. MOLECULAR MECHANISMS OF APOPTOSIS IN MYOCARDIAL ISCHEMIA
    Seigo Izumo; Fiscal Year: 2002
    ..of cardiomyocyte apoptosis following ischemia/reperfusion and its relation to the progression of ventricular remodeling and heart failure...
  65. Quantitative Force Measurements to Optimize Valve Repair for Ischemic MR
    Ajit P Yoganathan; Fiscal Year: 2013
    ..normal mitral valve (MV) is rendered incompetent as a result of myocardial infarction induced left ventricular remodeling. IMR effects between 1.6 to 2.8 million Americans...
  66. SPECIALIZED CENTER OF RESEARCH IN ISCHEMIC HEART DISEASE
    Michael Mendelsohn; Fiscal Year: 2004
    ..with the selective ER modulator raloxifene; Project 3: "Cardiac ER and MI: Mouse Models", studies of ventricular remodeling, arrhythmogenic changes, and myocardial gene expression in wild-type, ERalphaKO and ERbetaKO ventricular ..
  67. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2005
    ..Prolonged hypertension induces cardiac overload, which results in ventricular remodeling and cardiac fibrosis...