ventricular function

Summary

Summary: The hemodynamic and electrophysiological action of the HEART VENTRICLES.

Top Publications

  1. ncbi Alternans and spiral breakup in a human ventricular tissue model
    K H W J ten Tusscher
    Utrecht University, Department of Theoretical Biology, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1088-100. 2006
  2. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
  3. pmc A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates
    Aman Mahajan
    UCLA Cardiovascular Research Laboratory, Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biophys J 94:392-410. 2008
  4. doi Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle
    Francois Haddad
    Division of Cardiovascular Medicine, Stanford University, 770 Welch Rd, Suite 400, Palo Alto, CA 94304 5715, USA
    Circulation 117:1436-48. 2008
  5. ncbi Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 97:663-73. 2005
  6. pmc Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function
    Martin J Bishop
    University of Oxford Computing Laboratory, Parks Road, Oxford OX1 3QD, UK
    Am J Physiol Heart Circ Physiol 298:H699-718. 2010
  7. ncbi Left ventricular morphology, global and longitudinal function in normal older individuals: a cardiac magnetic resonance study
    Nikolay P Nikitin
    Academic Department of Cardiology, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull, HU16 5JQ United Kingdom
    Int J Cardiol 108:76-83. 2006
  8. ncbi A finite element model of the human left ventricular systole
    F Dorri
    Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH 8092, Zurich, Switzerland
    Comput Methods Biomech Biomed Engin 9:319-41. 2006
  9. pmc Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the multi-ethnic study of atherosclerosis)
    Harjit Chahal
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 106:110-6. 2010
  10. ncbi Accuracy and reproducibility of real-time three-dimensional echocardiography for assessment of right ventricular volumes and ejection fraction in children
    Xiuzhang Lu
    Baylor College of Medicine and Texas Children s Hospital, Houston, Texas 77030, USA
    J Am Soc Echocardiogr 21:84-9. 2008

Detail Information

Publications264 found, 100 shown here

  1. ncbi Alternans and spiral breakup in a human ventricular tissue model
    K H W J ten Tusscher
    Utrecht University, Department of Theoretical Biology, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1088-100. 2006
    ..Therefore, we conclude that steep APD restitution-mediated instability is a potential mechanism for VF in the human heart...
  2. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
    ..We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue...
  3. pmc A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates
    Aman Mahajan
    UCLA Cardiovascular Research Laboratory, Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biophys J 94:392-410. 2008
    ....
  4. doi Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle
    Francois Haddad
    Division of Cardiovascular Medicine, Stanford University, 770 Welch Rd, Suite 400, Palo Alto, CA 94304 5715, USA
    Circulation 117:1436-48. 2008
  5. ncbi Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 97:663-73. 2005
    ..In conclusion, the heart has an endogenous reserve of CSCs-ECCs that can be activated to reconstitute dead myocardium and recover cardiac function...
  6. pmc Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function
    Martin J Bishop
    University of Oxford Computing Laboratory, Parks Road, Oxford OX1 3QD, UK
    Am J Physiol Heart Circ Physiol 298:H699-718. 2010
    ..This highlights the utility of histoanatomically detailed models for investigations of cardiac function, in particular for future patient-specific modeling...
  7. ncbi Left ventricular morphology, global and longitudinal function in normal older individuals: a cardiac magnetic resonance study
    Nikolay P Nikitin
    Academic Department of Cardiology, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull, HU16 5JQ United Kingdom
    Int J Cardiol 108:76-83. 2006
    ..This study was designed to assess left ventricular (LV) morphology, global and longitudinal function in healthy older men and women using cardiac magnetic resonance (CMR)...
  8. ncbi A finite element model of the human left ventricular systole
    F Dorri
    Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH 8092, Zurich, Switzerland
    Comput Methods Biomech Biomed Engin 9:319-41. 2006
    ..We therefore, expect that the measurement of systolic deformation might provide useful diagnostic information...
  9. pmc Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the multi-ethnic study of atherosclerosis)
    Harjit Chahal
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 106:110-6. 2010
    ..Cardiovascular risk factors, especially blood pressure and high-density lipoprotein cholesterol, are associated with subclinical changes in the RV mass and volume...
  10. ncbi Accuracy and reproducibility of real-time three-dimensional echocardiography for assessment of right ventricular volumes and ejection fraction in children
    Xiuzhang Lu
    Baylor College of Medicine and Texas Children s Hospital, Houston, Texas 77030, USA
    J Am Soc Echocardiogr 21:84-9. 2008
    ..Measurement of right ventricular (RV) volumes and ejection fraction (EF) by two-dimensional echocardiography has limited accuracy and reproducibility because of the complex RV geometry...
  11. pmc Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
    Thomas O'Hara
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA
    PLoS Comput Biol 7:e1002061. 2011
    ..APD shortening during restitution was primarily dependent on reduced late Na(+) and I(CaL) currents due to inactivation at short diastolic intervals, with additional contribution from elevated I(Kr) due to incomplete deactivation...
  12. ncbi Role of individual ionic current systems in ventricular cells hypothesized by a model study
    Satoshi Matsuoka
    Department of Physiology and Biophysics, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Jpn J Physiol 53:105-23. 2003
    ..The model serves as a predictive tool in generating testable hypotheses...
  13. ncbi Left ventricular geometric patterns in the Jackson cohort of the Atherosclerotic Risk in Communities (ARIC) Study: clinical correlates and influences on systolic and diastolic dysfunction
    Ervin R Fox
    The NHLBI s Jackson Heart Study, Jackson, MS 39216, USA
    Am Heart J 153:238-44. 2007
    ....
  14. ncbi The pathophysiology of heart failure with normal ejection fraction: exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion
    Yu Ting Tan
    Department of Cardiovascular Medicine, University of Birmingham, Birmingham, UK
    J Am Coll Cardiol 54:36-46. 2009
    ....
  15. ncbi Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure
    Norbert F Voelkel
    Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, 4200 E Ninth Ave, MC C272, Denver, CO 80262, USA
    Circulation 114:1883-91. 2006
  16. ncbi Global endocardial electrical restitution in human right and left ventricles determined by noncontact mapping
    Arthur M Yue
    Wessex Cardiac Center, Southampton General Hospital, Southampton, United Kingdom
    J Am Coll Cardiol 46:1067-75. 2005
    ..This study was aimed at evaluating global characteristics of electrical restitution in the human ventricle using noncontact mapping...
  17. pmc Systolic and diastolic ventricular function in zebrafish embryos: influence of norepenephrine, MS-222 and temperature
    Martin A Denvir
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, EH16 4TJ, UK
    BMC Biotechnol 8:21. 2008
    ....
  18. ncbi Pulmonary vascular resistance, collateral flow, and ventricular function in patients with a Fontan circulation at rest and during dobutamine stress
    Boris Schmitt
    Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Berlin and The Charité, Medical University Berlin, Berlin, Germany
    Circ Cardiovasc Imaging 3:623-31. 2010
    ..The role, interplay, and relative importance of the multifactorial hemodynamic and myocardial mechanisms causing dysfunction of the Fontan circulation remain incompletely understood...
  19. ncbi Quantitative assessment of ventricular function using three-dimensional SSFP magnetic resonance angiography
    Gerald F Greil
    Department of Pediatric Cardiology, Children s Hospital, University of Tuebingen, Tuebingen, Germany
    J Magn Reson Imaging 26:288-95. 2007
    To evaluate three-dimensional (3D), free-breathing, steady-state free precession (SSFP) magnetic resonance angiography (MRA) for volumetric assessment of ventricular function.
  20. ncbi Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imaging
    Patrick Helm
    The Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21218, USA
    Ann N Y Acad Sci 1047:296-307. 2005
    ....
  21. ncbi Contributions of HERG K+ current to repolarization of the human ventricular action potential
    Martin Fink
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Prog Biophys Mol Biol 96:357-76. 2008
    ..Our overall goal is to understand the genesis of the T-wave of the human electrocardiogram...
  22. ncbi Systemic right ventricular longitudinal strain is reduced in adults with transposition of the great arteries, relates to subpulmonary ventricular function, and predicts adverse clinical outcome
    Gerhard Paul Diller
    Adult Congenital Heart Disease Programme, Royal Brompton Hospital, London, United Kingdom
    Am Heart J 163:859-66. 2012
    ..the value of indices of myocardial deformation on speckle-tracking echocardiography for quantifying ventricular function and their potential role in assessing ventricular-ventricular interaction and outcome in patients with a ..
  23. pmc High- and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity
    Anne D Hafstad
    Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
    Diabetes 62:2287-94. 2013
    ....
  24. ncbi Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis
    Ahmed Abdel-Latif
    Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Arch Intern Med 167:989-97. 2007
    ..that therapy with adult bone marrow (BM)-derived cells (BMCs) reduces infarct size and improves left ventricular function and perfusion...
  25. ncbi Subclinical impairment of left ventricular function in young obese women: contributions of polycystic ovary disease and insulin resistance
    Wojciech Kosmala
    University of Queensland Department of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, Q4102, Australia
    J Clin Endocrinol Metab 93:3748-54. 2008
    ..Obese women with polycystic ovary syndrome (PCO), characterized by hormonal and metabolic abnormalities, are thought to be at particularly increased cardiovascular risk...
  26. ncbi Injection of adeno-associated viral vector encoding vascular endothelial growth factor gene in infarcted swine myocardium: MR measurements of left ventricular function and strain
    Alexis Jacquier
    Department of Radiology, University of California San Francisco, 513 Parnassus Ave, HSW 207 B, San Francisco, CA 94134 0628, USA
    Radiology 245:196-205. 2007
    ....
  27. ncbi The structure and function of the helical heart and its buttress wrapping. VII. Critical importance of septum for right ventricular function
    G D Buckberg
    Department of Surgery, University of California at Los Angeles Medical Center, Los Angeles, 90095-1741, USA
    Semin Thorac Cardiovasc Surg 13:402-16. 2001
    ..Data is presented that determines why right ventricular function is related principally to intraventricular septal function, and why right ventricular failure is magnified ..
  28. ncbi Opioids and cardioprotection: the impact of morphine and fentanyl on recovery of ventricular function after cardiopulmonary bypass
    Glenn S Murphy
    Department of Anesthesiology, Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    J Cardiothorac Vasc Anesth 20:493-502. 2006
    ..The present study investigated the effect of the choice of intraoperative opioid (morphine or fentanyl) on recovery of myocardial function after coronary artery bypass graft (CABG) surgery...
  29. ncbi Arrhythmogenesis in the short-QT syndrome associated with combined HERG channel gating defects: a simulation study
    Hideki Itoh
    Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    Circ J 70:502-8. 2006
    ..This study aimed to show the mechanism how the HERG channel gating defects causes life-threatening arrhythmia in the short-QT syndrome, using a simulation model of ventricular action potentials (APs)...
  30. ncbi Spinal cord stimulation improves ventricular function and reduces ventricular arrhythmias in a canine postinfarction heart failure model
    John C Lopshire
    Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Circulation 120:286-94. 2009
    Spinal cord stimulation (SCS) reduces the incidence of ventricular tachyarrhythmias in experimental models. This study investigated the effects of long-term SCS on ventricular function in a postinfarction canine heart failure model.
  31. ncbi A new multi-scale simulation model of the circulation: from cells to system
    Eun Bo Shim
    Department of Mechanical and Biomedical Engineering, Kangwon National University, Hyoja Dong, Chuncheon, Kangwon 200 701, South Korea
    Philos Transact A Math Phys Eng Sci 364:1483-500. 2006
    ..The variation due to different pacing frequencies for myocyte excitation was also investigated to assess the effects of heart rate on cardiac cells and the circulatory system...
  32. ncbi Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging
    Lucy E Hudsmith
    The University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, The John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 7:775-82. 2005
    ....
  33. pmc An isolated perfused pig heart model for the development, validation and translation of novel cardiovascular magnetic resonance techniques
    Andreas Schuster
    King s College London BHF Centre of Excellence, NIHR Biomedical Research Centre, Guy s and St, Thomas NHS Foundation Trust, Division of Imaging Sciences, The Rayne Institute, London, UK
    J Cardiovasc Magn Reson 12:53. 2010
    ..The aim of this study is to overcome these limitations by introducing an MR-compatible, free beating, blood-perfused, isolated pig heart model for the development of novel CMR methodology...
  34. ncbi Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, Netherlands
    Circulation 107:2753-60. 2003
    ..In large mammals and humans, the contribution of IKs to ventricular repolarization is still incompletely understood...
  35. ncbi Transplantation of adipose-derived stem cells overexpressing hHGF into cardiac tissue
    Xiao yu Zhu
    Department of Hematology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510080, PR China
    Biochem Biophys Res Commun 379:1084-90. 2009
    ..Results indicated that transplantation of ADSCs led to improvement of left ventricular function, explained partly through their ability to differentiate into endothelial cells, resulting in increased ..
  36. ncbi Noninvasive assessment of left ventricular force-frequency relationships using tissue Doppler-derived isovolumic acceleration: validation in an animal model
    Michael Vogel
    Cardiothoracic Unit, Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Circulation 107:1647-52. 2003
    ..In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental preparation...
  37. ncbi Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging
    Nikolay P Nikitin
    Department of Cardiology, University of Hull School of Medicine, Cottingham, Kingston upon Hull, United Kingdom
    J Am Soc Echocardiogr 16:906-21. 2003
    ..The aim of this study was to obtain normal values for atrioventricular annular and regional myocardial velocities using this method...
  38. ncbi Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function
    Xiaoli Liu
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    FASEB J 20:207-16. 2006
    ..Our data indicate that rAAV-HO-1 gene transfer markedly reduces fibrosis and ventricular remodeling and restores LV function and chamber dimensions after myocardial infarction...
  39. ncbi Ablation of cardiac myosin-binding protein-C accelerates stretch activation in murine skinned myocardium
    Julian E Stelzer
    Department of Physiology, University of Wisconsin School of Medicine, Madison, WI 53711, USA
    Circ Res 98:1212-8. 2006
    ....
  40. ncbi Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships
    D A Kass
    Johns Hopkins Medical Institutions, Department of Medicine, Baltimore, MD
    Circulation 76:1422-36. 1987
    ..Any advantage of the ESPVR will derive not from the magnitude of its response to inotropic change, which is smaller than most other indexes, but from its relative insensitivity to load alteration over a wider range of load...
  41. ncbi The cross-bridge dynamics during ventricular contraction predicted by coupling the cardiac cell model with a circulation model
    Eun Bo Shim
    Cell Biodynamics Simulation Project, Kyoto University, Kyoto, Japan
    J Physiol Sci 57:275-85. 2007
    ....
  42. ncbi Echocardiographic evaluation of ventricular function in mice
    Jeffrey N Rottman
    Division of Cardiovascular Medicine, Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6300, USA
    Echocardiography 24:83-9. 2007
    ..This review describes the measurement of ventricular function, most often left ventricular function, by echocardiographic methods in mice...
  43. ncbi Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito
    Fadi G Akar
    Institute of Molecular Cardiobiology, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 286:H602-9. 2004
    ....
  44. ncbi Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes
    Ting Ting Pan
    Cardiovascular Research Group, Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore, 117597
    J Mol Cell Cardiol 40:119-30. 2006
    ....
  45. ncbi Quantification in cardiac MRI: advances in image acquisition and processing
    Anil K Attili
    Department of Radiology and Cardiology, University of Kentucky, Lexington, KY, USA
    Int J Cardiovasc Imaging 26:27-40. 2010
    ..CMR) imaging enables accurate and reproducible quantification of measurements of global and regional ventricular function, blood flow, perfusion at rest and stress as well as myocardial injury...
  46. ncbi Ventricular mechanics in diastole: material parameter sensitivity
    Carey Stevens
    Faculty of Engineering, Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Biomech 36:737-48. 2003
    ....
  47. ncbi Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study
    S R Ommen
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 102:1788-94. 2000
    ..However, accurate prediction of filling pressures for an individual patient requires a stepwise approach incorporating all available data...
  48. ncbi Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes
    P G Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Circulation 100:2455-61. 1999
    ..We examined whether K(+)-current alterations contribute to these proarrhythmic responses in an animal model of TdP: the dog with chronic complete atrioventricular block (AVB) and biventricular hypertrophy...
  49. ncbi Altered dynamics of action potential restitution and alternans in humans with structural heart disease
    Marcus L Koller
    Department of Cardiology, University of Wurzburg, 97080 Wurzburg, Germany
    Circulation 112:1542-8. 2005
    ..In this study, we tested the hypothesis that APD restitution and alternans properties differ between normal and diseased human ventricular myocardium...
  50. ncbi Quantification of right ventricular afterload in patients with and without pulmonary hypertension
    Jan Willem Lankhaar
    Dept of Pulmonary Diseases, VU Univ Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1731-7. 2006
    ..Furthermore, the data suggest that the RC time and the elastic properties of the large pulmonary arteries remain unchanged in PH...
  51. ncbi Temporal changes in ventricular function assessed echocardiographically in conscious and anesthetized mice
    Jeffrey N Rottman
    Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
    J Am Soc Echocardiogr 16:1150-7. 2003
    ..Serial echocardiographic assessments of cardiac function, dimension, and mass can be performed with high reproducibility in conscious mice...
  52. ncbi Granulocyte colony stimulating factor/macrophage colony stimulating factor improves postinfarct ventricular function by suppression of border zone remodelling in rats
    Takayuki Miki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Clin Exp Pharmacol Physiol 31:873-82. 2004
    ..cells by granulocyte colony stimulating factor (G-CSF) and macrophage colony stimulating factor (M-CSF) on ventricular function after myocardial infarction (MI). 2...
  53. ncbi [Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure]
    Pablo Castro
    Departamento de Enfermedades Cardiovasculares, Hospital Clínico Universidad Católica de Chile, Santiago de Chile, Chile
    Rev Esp Cardiol 57:1053-8. 2004
    ..The aim of the present study was to evaluate clinical parameters, left ventricular function, oxidative stress levels and neurohumoral status at baseline and after 6 months of treatment with ..
  54. ncbi Three-dimensional assessment of two-dimensional technique for evaluation of right ventricular function by tricuspid annulus motion
    Jordan L Smith
    Cardiovascular Research and Training Center, University of Washington, Seattle, WA, USA
    Int J Cardiovasc Imaging 19:189-97. 2003
    ..However the accuracy of two-dimensional (2-D) methods for analyzing the three-dimensional (3-D) structure of the tricuspid annulus has not been evaluated...
  55. ncbi Intra-observer and interobserver reproducibility of right ventricle volumes, function and mass by cardiac magnetic resonance
    Oronzo Catalano
    Division of Cardiology, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
    J Cardiovasc Med (Hagerstown) 8:807-14. 2007
    ..We have evaluated CMR intra- and interobserver reproducibility in different conditions of RV dimension and function...
  56. pmc Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation
    Gregory M Faber
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Biophys J 92:1522-43. 2007
    ..2 is greater at negative potentials, when VDI is weak; and 5), loss of VDI due to the Ca(V)1.2 mutation G406R (linked to the Timothy syndrome) results in APD prolongation and increased CaT...
  57. ncbi The effect of altering heart rate on ventricular function in patients with heart failure treated with beta-blockers
    Simon D R Thackray
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    Am Heart J 152:713.e9-13. 2006
    ..Beta-blockers are effective for the treatment of heart failure, but their mechanism of action is unresolved. Heart rate reduction may be a central mechanism or a troublesome side effect...
  58. pmc Noninvasive measurement of myocardial tissue volume change during systolic contraction and diastolic relaxation in the canine left ventricle
    Ignacio Rodriguez
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, ational Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 55:484-90. 2006
    ..The result supports the notion of high arterial resistance at the microvascular level from intramyocardial pressure during systole...
  59. ncbi Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function
    Vincent J A Bourgonje
    Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
    Circ Arrhythm Electrophysiol 6:371-9. 2013
    ....
  60. ncbi Quantitative assessment of ventricular function in children with single ventricles using the Doppler myocardial performance index
    R V Williams
    Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    Am J Cardiol 86:1106-10. 2000
    Assessment of ventricular function in patients with functionally single ventricles and unusual ventricular geometry is difficult. The Doppler myocardial performance index (MPI) may provide a method of assessing function in these patients...
  61. ncbi Enhanced cell transplantation: preventing apoptosis increases cell survival and ventricular function
    Yoshinobu Nakamura
    Department of Surgery, Division of Cardiac Surgery, Toronto General Research Institute, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 291:H939-47. 2006
    ..that antiapoptosis pretreatments reduced grafted SMC loss after transplantation and enhanced grafted cell survival and ventricular function, which was directly related (r = 0.72; P = 0.002) to the number of surviving engrafted cells.
  62. ncbi Effect of sex, age, and weight on ejection fraction and end-systolic volume reference limits in gated myocardial perfusion SPECT
    Richard A Peace
    Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom
    J Nucl Cardiol 15:86-93. 2008
    ..Our aim was to derive male and female reference limits for left-ventricular functional parameters, and determine the effect of age, weight, and body surface area (BSA)...
  63. ncbi Action potential prolongation and potassium currents in left-ventricular myocytes isolated from hypertrophied rabbit hearts
    M A McIntosh
    Department of Medical Cardiology, Royal Infirmary, Glasgow University, UK
    J Mol Cell Cardiol 30:43-53. 1998
    ..In conclusion, LVH induced by perinephritis hypertension in the rabbit is associated with a prolongation in APD. Reductions in IKl, sustained outward current and Ito may contribute to the prolongation in APD...
  64. ncbi Strain echocardiographic assessment of ventricular function after percutaneous pulmonary valve implantation
    Nasser Moiduddin
    The Heart Center at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Congenit Heart Dis 7:361-71. 2012
    ..Minimal data on the midterm effects of PPVI on ventricular function exist...
  65. ncbi Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Eur J Nucl Med Mol Imaging 40:315-24. 2013
    ..We evaluated whether long-term exercise-based cardiac rehabilitation started early after ST-elevation acute myocardial infarction (STEMI) improves myocardial perfusion and left ventricular (LV) function...
  66. pmc Phenotyping of left and right ventricular function in mouse models of compensated hypertrophy and heart failure with cardiac MRI
    Bastiaan J van Nierop
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    PLoS ONE 8:e55424. 2013
    ....
  67. ncbi Myocardial adaptation to short-term high-intensity exercise in highly trained athletes
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115 2696, USA
    J Am Soc Echocardiogr 19:1280-5. 2006
    ..In conclusion, maximal intensity short-duration exercise was associated with attenuation of LV diastolic function, augmentation of LV systolic function, and a reduction in apical right ventricular contractility...
  68. ncbi Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI
    Junjie Chen
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University, St Louis, Missouri, USA
    Am J Physiol Heart Circ Physiol 289:H1898-907. 2005
    Dynamic changes of myocardial fiber and sheet structure are key determinants of regional ventricular function. However, quantitative characterization of the contraction-related changes in fiber and sheet structure has not been reported...
  69. ncbi Modeling ventricular repolarization: effects of transmural and apex-to-base heterogeneities in action potential durations
    P Colli Franzone
    Dipartimento di Matematica, Istituto di Analisi Nuerica C N R, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Math Biosci 214:140-52. 2008
    ..These findings are independent of the stimulus location (epicardial, endocardial) and of Purkinje involvement...
  70. ncbi Reproducibility of the ventricular synchronization parameters assessed by multiharmonic phase analysis of radionuclide angiography in the normal heart
    J F Toussaint
    Physiology and Radioisotopes Unit, Hĵpital Européen Georges Pompidou, Paris, France
    Int J Cardiovasc Imaging 18:187-94. 2002
    ..These results, consistent with published electrophysiological data, provide the basis for further non-invasive investigations of ventricular resynchronization in patients with basal electrical or mechanical asynchrony...
  71. ncbi Activated human platelet products induce proarrhythmic effects in ventricular myocytes
    Jonas S S G De Jong
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Mol Cell Cardiol 51:347-56. 2011
    ..These changes may trigger and support reentrant arrhythmias in ischemia models of coronary thrombosis...
  72. ncbi Ventricular function abnormalities in active rheumatoid arthritis: a Doppler echocardiographic study
    Funda Levendoglu
    Department of Physical Medicine and Rehabilitation, Meram Medical School of Selcuk University, Meram Konya, Turkey
    Rheumatol Int 24:141-6. 2004
    ..The aim of the present study was to evaluate cardiac involvement in patients with active rheumatoid arthritis (RA)...
  73. ncbi Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model
    Atsushi Iwakura
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan
    Heart Vessels 18:93-9. 2003
    ..was to assess whether bFGF-incorporating gelatin hydrogels induce myocardial angiogenesis and improve left ventricular function in the infarcted myocardium of rats...
  74. ncbi Assessment of right heart function in the athlete's heart
    Mustafa Kemal Erol
    Department of Cardiology, Medical School Hospital, Ataturk University, 25050 Erzurum, Turkey
    Heart Vessels 16:175-80. 2002
    ..They suggest that these changes are a normal physiologic adaptation to prolonged training...
  75. ncbi Preservation of ventricular function in amateur athletes after completion of a marathon
    Allison J Kean
    Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Am Soc Echocardiogr 19:202-5. 2006
    ..Limited information is available on the effect of an endurance event such as a marathon on the left ventricular indices and hemodynamics...
  76. pmc Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks
    Blanca Rodriguez
    Tulane University, New Orleans, LA, USA
    Circ Res 97:168-75. 2005
    ..Knowledge regarding the location of the main postshock excitable area within the 3-D ventricular volume could be important for improving defibrillation efficacy...
  77. ncbi Validation and application of single breath-hold cine cardiac MR for ventricular function assessment in children with congenital heart disease at rest and during adenosine stress
    Andrew M Taylor
    Department of Radiology, Gasthuisberg University Hospital, Leuven, Belgium
    J Cardiovasc Magn Reson 7:743-51. 2005
    To validate the accuracy of ventricular function analysis using a single breath-hold real-time steady sate free precession (SSFP) cine MR method and demonstrate its application during adenosine stress imaging in children with congenital ..
  78. ncbi Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice
    Rajan Sah
    Department of Physiology and the Division of Cardiology, University Health Network, University of Toronto, Toronto, Canada
    Circulation 105:1850-6. 2002
    ..2N mice results from elevations in intracellular calcium ([Ca2+]i) secondary to AP prolongation and investigated the putative roles of calcineurin activation in heart disease development of K(v)4.2N mice...
  79. pmc A model-based time-reversal of left ventricular motion improves cardiac motion analysis using tagged MRI data
    Tareq Alrefae
    Physics, Kuwait University, Khaldia, Kuwait
    Biomed Eng Online 7:15. 2008
    ..This paper addresses this issue and provides a solution to make such measurements possible...
  80. pmc In-vivo validation of a new non-invasive continuous ventricular stroke volume monitoring system in an animal model
    Maurits K Konings
    Department of Medical Technology and Clinical Physics, University Medical Center Utrecht, 100 Heidelberglaan, Utrecht 3584 CX, The Netherlands
    Crit Care 15:R165. 2011
    ..A prototype using this new method was built (the hemologic cardiac profiler, HCP) and validated against a reference method in a pig model during variations in cardiac output...
  81. ncbi A comparative echocardiographic assessment of ventricular function in five species of sharks
    N Chin Lai
    Marine Biology Research Division and Center for Marine Biotechnology and Biomedicine, Scripps Institute of Oceanography, University of California San Diego, San Diego, CA, USA
    Comp Biochem Physiol A Mol Integr Physiol 137:505-21. 2004
    ..The study contrasted the ventricular function in the highly active mako shark (heart type IV) and four other sharks (heart type III) that differ in ..
  82. ncbi Normal limits of gated blood pool SPECT count-based regional cardiac function parameters
    Kenneth J Nichols
    Division of Nuclear Medicine, North Shore Long Island Jewish Health System, 270 05 76th Avenue, New Hyde Park, NY 11040, USA
    Int J Cardiovasc Imaging 24:717-25. 2008
    ..This investigation sought to establish LV and RV count-based GBPS regional functional normal limits and to quantify their reproducibility...
  83. ncbi Principal strain orientation in the normal human left ventricle
    Brian P Cupps
    Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Thorac Surg 79:1338-43. 2005
    ....
  84. pmc Supernormal left ventricular diastolic function in triathletes
    P J Claessens
    Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium
    Tex Heart Inst J 28:102-10. 2001
    ..We determined that triathletes may develop supernormal left ventricular diastolic function with increased diastolic reserves...
  85. ncbi Myocardial performance during progressive exercise in athletic adolescent males
    Thomas W Rowland
    Department of Pediatrics, Baystate Medical Center, Springfield, MA, USA
    Med Sci Sports Exerc 41:1721-8. 2009
    The extent that enhanced ventricular function contributes to superior aerobic fitness of trained athletes is unclear...
  86. ncbi Device-guided paced breathing in the home setting: effects on exercise capacity, pulmonary and ventricular function in patients with chronic heart failure: a pilot study
    Gianfranco Parati
    Department of Cardiology, S Luca Hospital, IRCCS, Istituto Auxologico Italiano, Milan, Italy
    Circ Heart Fail 1:178-83. 2008
    ..Regular slow breathing is known to improve autonomic cardiac regulation and reduce chemoreflex sensitivity in heart failure. We explored the acceptability and usefulness of a device for paced slow breathing at the home setting...
  87. ncbi The impact of marathon running upon ventricular function as assessed by 2D, Doppler, and tissue-Doppler echocardiography
    David Oxborough
    Cardiac Ultrasound Department, Leeds General Infirmary, Leeds, UK
    Echocardiography 23:635-41. 2006
    ..Conversely, a reduction in diastolic function was observed in both ventricles for which a mechanism has yet to be deduced...
  88. ncbi Systolic coronary flow impediment in the dog: role of ventricular pressure and contractility
    P Pagliaro
    Division of Biomedical Sciences, King s College London, London WC2R 2LS, UK
    Exp Physiol 83:821-31. 1998
    ..When systolic pressure exceeds 100 mmHg the shielding effect is overcome and the amplitude of the systolic flow reduction varies with ventricular pressure...
  89. ncbi Imaging of ventricular function by cardiovascular magnetic resonance
    Vikas K Rathi
    Cardiovascular MRI, Allegheny General Hospital, Drexel University, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Curr Cardiol Rep 6:55-61. 2004
    ..has vaulted to the forefront as the ideal diagnostic modality for the evaluation of both left and right ventricular function. The accumulated literature supports this contention for the left ventricle...
  90. ncbi Assessment of diastolic ventricular function in fetuses of diabetic mothers using tissue Doppler
    Maria Amélia Bulhões Hatém
    Fetal Cardiology Unit, Institute of Cardiology of Rio Grande do Sul Universitary Cardiology Foundation, Porto Alegre, Brazil
    Cardiol Young 18:297-302. 2008
    ..To identify the presence of ventricular diastolic dysfunction by tissue Doppler in fetuses of diabetic mothers, with or without septal hypertrophy, in comparison to fetuses of nondiabetic mothers...
  91. pmc Right ventricular function and failure: a review
    R Hines
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 64:295-307. 1991
    ..The physiological determinants of normal right ventricular function will be discussed, with particular emphasis on the afterload and contractility characteristics of the right ..
  92. ncbi Effects of weight loss after gastric bypass on right and left ventricular function assessed by tissue Doppler imaging
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami School of Medicine, Miami, Florida 33021 8437, USA
    Am J Cardiol 95:1521-4. 2005
    ..6 +/- 2.5 to 10.3 +/- 2.7 cm/s, p = 0.037). In patients with severe obesity, significant weight loss results in an increase in tricuspid annular systolic and early diastolic velocities and mitral annular early diastolic velocities...
  93. ncbi Fast LV motion estimation using subspace approximation techniques
    Y P Wang
    The Advanced Digital Imaging Research, LLC, League City, TX 77573, USA
    IEEE Trans Med Imaging 20:499-513. 2001
    ..The method is applied to a temporal sequence of two-dimensional images and is validated with simulated and in vivo heart data...
  94. pmc Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential
    M Rocchetti
    Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    J Physiol 534:721-32. 2001
    ..The mechanisms identified are such as to contribute to abnormal rate dependency of repolarization in prolonged repolarization syndromes...
  95. pmc Quantification of myocardial strain at early systole in mouse heart: restoration of undeformed tagging grid with single-point HARP
    Wei Li
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44122, USA
    J Magn Reson Imaging 32:608-14. 2010
    ..To develop accurate strain and torsion quantification method for the assessment of myocardial contraction in mice by MRI tagging...
  96. ncbi Impact of ionic current variability on human ventricular cellular electrophysiology
    Lucia Romero
    Instituto de Investigación Interuniversitario en Bioingeniería y Tecnología Orientada al Ser Humano, Universidad Politecnica de Valencia, Valencia, Spain
    Am J Physiol Heart Circ Physiol 297:H1436-45. 2009
    ..The results show the importance of sensitivity analysis as a powerful method for the in-depth validation of mathematical models in cardiac electrophysiology...
  97. ncbi Measurement of strain and strain rate by echocardiography: ready for prime time?
    Thomas H Marwick
    University of Queensland Department of Medicine, Princess Alexandra Hospital, Brisbane, Australia
    J Am Coll Cardiol 47:1313-27. 2006
    ..Echocardiographic strain and SR imaging has been applied to the assessment of resting ventricular function, the assessment of myocardial viability using low-dose dobutamine infusion, and stress testing for ischemia...
  98. ncbi Nuclear targeting of Akt enhances ventricular function and myocyte contractility
    Marcello Rota
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 97:1332-41. 2005
    ..Together, these observations provide a plausible biochemical mechanism for the potentiation of myocyte and ventricular function in Akt transgenic mice...
  99. ncbi Assessment of ventricular function and mass by cardiac magnetic resonance imaging
    Khaled Alfakih
    British Heart Foundation Cardiac MRI Unit, The General Infirmary at Leeds, Great George Street, Leeds, UK
    Eur Radiol 14:1813-22. 2004
    ..The excellent reproducibility makes temporal follow-up of any individual patient in the clinical setting a realistic possibility. This review examines the merits of CMR and describes the techniques used...
  100. ncbi Fast tracking of cardiac motion using 3D-HARP
    Li Pan
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, 601 N Caroline St JHOC 4240, Baltimore, MD 21287, USA
    IEEE Trans Biomed Eng 52:1425-35. 2005
    ..8605 and r2 = 0.8645, respectively. The total time required for tracking 3-D cardiac motion is approximately 10 min in a 9 timeframe tagged MRI dataset and has the potential to be much faster...
  101. pmc Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels
    Tian Xue
    Department of Cell Biology and Human Anatomy, University of California, Davis, USA
    Circulation 115:1839-50. 2007
    ....

Research Grants76

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..under investigation include: 1) Deferoxamine (DFO) and deferiprone (L1) combination therapy improves left ventricular function more rapidly than DFO/placebo therapy among transfusion dependent beta-thalassemia patients with abnormal ..
  2. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..non-invasive assessment by 2-dimensional echocardiography of pulmonary artery systolic pressure and right ventricular function, dyspnea severity, health related quality of life assessed by validated standardized questionnaires, and, ..
  3. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2012
    ..These primary myoblasts have demonstrated engraftment and improvement in left ventricular function but with adverse event of arrhythmia...
  4. Inflammation and Repair in Cardiac Ischemia-Reperfusion
    Lewis C Becker; Fiscal Year: 2011
    ..models of (1) myocardial ischemia-reperfusion with measurement of infarct size and assessment of left ventricular function by echocardiography and pressure-volume loops and (2) post-ischemic inflammation of the cremaster muscle ..
  5. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..whether in the coronary fibrinolysis model in dogs, APT102 promotes improved myocardial perfusion and left ventricular function with minimal bleeding compared with clopidogrel...
  6. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..clearly demonstrate that physiological levels of H2S significantly ameliorate MI-R injury and preserve left ventricular function. Preliminary data also indicate that H2S therapy triggers both "early" and "late" myocardial ..
  7. Diet and pathophysiology of heart failure with preserved ejection fraction
    Scott L Hummel; Fiscal Year: 2013
    ..We will report diet-induced changes in blood pressure and in vascular and ventricular function using standard and novel non-invasive measures...
  8. Cell Based Therapies for Cystic Fibrosis
    Tracey L Bonfield; Fiscal Year: 2012
    ..Translational and early-phase clinical research has demonstrated that cell-based therapies may improve left ventricular function, reduce myocardial ischemia and lead to improved lung function...
  9. Sex Differences in Myocardial Ischemia Triggered by Emotional Factors after MI
    Viola Vaccarino; Fiscal Year: 2010
    ..or treatments, and occur despite the fact that women have less coronary atherosclerosis and more preserved ventricular function than men...
  10. Development of an In Vivo Stem Cell Tracking Method Using Ultrasound Imaging
    Flordeliza S Villanueva; Fiscal Year: 2010
    ..adult bone marrow or marrow-derived mesenchymal stem cells (MSCs) has improved perfusion and indices of ventricular function. The mechanisms of beneficial effect are incompletely understood, partly because methods are limited for ..
  11. Inhibition of GRK2 to Prevent Ventricular Remodeling and Heart Failure After CABG
    Shahab A Akhter; Fiscal Year: 2013
    ..grafting (CABG), long-term survival is markedly inferior for patients who present with depressed left ventricular function post-myocardial infarction...
  12. Computational Modeling and Accelerated Aging of the Ascending Aorta
    Jay D Humphrey; Fiscal Year: 2013
    ..to elucidate underlying biomechanical causes of thoracic aortic aneurysms and dissections, diminished left ventricular function due to stiffening of the aorta, and deleterious systemic hemodynamics as well as an improved design of ..
  13. Ubiquitin-like protein modification in diabetic cardiomyopathy
    Jay Yang; Fiscal Year: 2013
    ..factor for both mortality and morbidity following myocardial infarction (MI), especially since post-MI left ventricular function is significantly worse in DM patients...
  14. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2009
    ..Here, we test the hypothesis that PM uniquely challenges the pulmonary vasculature and right ventricular function. The protection afforded by natriuretic peptides wanes with age leaving the pulmonary vasculature and right ..
  15. The Comparative Effectiveness of Single versus Dual Chamber Cardioverter Defibril
    Pamela N Peterson; Fiscal Year: 2013
    ..ICDs) for the primary prevention of sudden cardiac death in patients with HF and reduced left ventricular function has increased. However, these trials leave many questions, including optimal device selection, unanswered...
  16. The role of the extracellular biophysical and biomechanical milieu in CHDs
    Lauren D Black; Fiscal Year: 2013
    ..Decreased cardiac tropoelastin and procollagen gene expression and decreased left ventricular function in LHH compared to normal hearts suggest that significant deviations from normal ECM composition and ..
  17. Low Thyroid function and myocardial infarction
    Anthony Martin Gerdes; Fiscal Year: 2013
    ..New data from rats shows that TH treatment of MI improved left ventricular function without elevating heart rate and led to a remarkable change in myocyte shape and reduced chamber diameter/..
  18. Pathogen specific imaging of endocarditis
    PETER ROLF PANIZZI; Fiscal Year: 2013
    ..PET/MRI, thereby combining a sensitive molecular modality (PET) with a leading modality for assessing left ventricular function which can also detect valvular insufficiency (MRI)...
  19. UFCC for Cardiovascular Cell Therapy Research Network
    Carl J Pepine; Fiscal Year: 2011
    ..Specific aims test whether skeletal myoblasts'(SkM) effect on ventricular function will be dependent on the presence of cells and not a reaction to the implantation process...
  20. Nonclinical Studies to Advance Novel Drug for Post-STEMI Cardiac Regeneration
    HYNDA KAREN KLEINMAN; Fiscal Year: 2010
    ..cardiac tissue, decreased infarct size, decreased inflammation, promoted angiogenesis, and improved ventricular function and animal survival...
  21. Treatment of Functional Impairment in Heart Failure Patients with Depression
    Kenneth E Freedland; Fiscal Year: 2012
    ..evaluation will assess depression, HF self-care, and quality of life, as well as medical history, left ventricular function via echocardiography, biomarkers including BNP and CRP, 6-minute walk test performance, physical activity ..
  22. Right Ventricular-Pulmonary Vascular Interactions in Pulmonary Hypertension
    Naomi C Chesler; Fiscal Year: 2013
    ..changes in these interactions with PAH progression and to quantify the effects of exercise on right ventricular function. We have a particular interest in the subpopulation of PAH with systemic sclerosis (SSc) because we ..
  23. Amplification of Cardiosphere-Derived Cell Therapy
    BRIAN RAYMOND WEIL; Fiscal Year: 2013
    ..regenerative potential for the development of cell-based therapies to reverse myocyte loss and improve ventricular function in patients with ischemic heart disease...
  24. T helper 2 Inflammation &Severe Muscularization of Arteries in the Lungs.
    Gabriele Grunig; Fiscal Year: 2013
    ..of IL-17 and IL-33 thereby directly determining the degree of pulmonary arterial muscularization and right ventricular function. The long range goal of this work takes advantage of the mouse model developed in my laboratory to identify ..
  25. Scalable Units for Building Vascularized Cardiac Graft
    Lisa E Freed; Fiscal Year: 2013
    ..We will test the hypotheses that elastomeric scaffolds will preserve ventricular function post-MI, exogenous heart cells will survive and integrate electromechanically with host myocardium, and ..
  26. Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial
    Inga Peter; Fiscal Year: 2012
    ..relationship of variants in the candidate genes with in-hospital and short-term plasma and left ventricular function markers will be tested in a subset of ~412 confirmed ACS cases who get extensive evaluation and return for ..
  27. Myocardial Effects of Erythropoietin During Resuscitation from Cardiac Arrest
    RAUL JAIME GAZMURI; Fiscal Year: 2013
    ..function enabling preservation of left ventricular compli- ance during VF and preservation of left ventricular function after return of spontaneous circulation, (2) whether these effects are mediated through activation and ..
  28. MESA
    Karol Watson; Fiscal Year: 2010
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  29. MESA
    Karol Watson; Fiscal Year: 2011
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  30. MESA
    Karol Watson; Fiscal Year: 2012
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  31. Advanced Glycation End-Products in Human Myocardium
    Martin M LeWinter; Fiscal Year: 2011
    ..in the Operating Room from patients undergoing coronary bypass grafting who have well-preserved left ventricular function. In Aim 1 we will quantify AGE abundance in relation to the presence or absence of DM, HTN and DM+HTN and ..
  32. MESA
    Karol Watson; Fiscal Year: 2009
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  33. 4D MRI Development for Cardiovascular Imaging
    Jing Liu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Assessments of coronary artery disease and ventricular function are crucial elements for heart health evaluation...
  34. A PDGFR inhibitor for the treatment of pulmonary arterial hypertension
    Lawrence S Zisman; Fiscal Year: 2010
    ..The effect of study drug on right ventricular function will be evaluated with echocardiography, and a new admittance technology to generate pressure-volume loops...
  35. Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRI
    Raymond Y Kwong; Fiscal Year: 2012
    ..Cardiac magnetic resonance imaging (CMR) can characterize myocardial tissue changes and ventricular function after MI...
  36. Vagus stimulation protects against cardiac diastolic dysfunction in aging mice
    Yi Fan Li; Fiscal Year: 2010
    ..Left ventricular function will be assessed using Millar Pressure-Volume catheter...
  37. MESA
    Richard A Kronmal; Fiscal Year: 2013
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  38. MESA
    Russell P Tracy; Fiscal Year: 2013
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  39. MESA
    Richard A Kronmal; Fiscal Year: 2012
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  40. MESA
    Aaron R Folsom; Fiscal Year: 2012
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  41. MESA
    Richard A Kronmal; Fiscal Year: 2011
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  42. MESA
    Aaron R Folsom; Fiscal Year: 2011
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  43. MESA
    Aaron R Folsom; Fiscal Year: 2013
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  44. MESA
    Russell P Tracy; Fiscal Year: 2011
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  45. MESA
    Russell P Tracy; Fiscal Year: 2012
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  46. MESA
    Russell P Tracy; Fiscal Year: 2010
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  47. MESA
    Aaron R Folsom; Fiscal Year: 2010
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  48. MESA
    Richard A Kronmal; Fiscal Year: 2010
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  49. Effects of Mechanical Unloading on Myocardial Function and Structure in Humans
    Josef Stehlik; Fiscal Year: 2013
    ..In a subset of patients, LVAD unloading results in sustained improvement of left ventricular function, but the clinical or pathologic features associated with this functional recovery are not well described...
  50. MESA
    Russell P Tracy; Fiscal Year: 2009
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  51. MESA
    Aaron R Folsom; Fiscal Year: 2009
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  52. MESA
    Richard A Kronmal; Fiscal Year: 2009
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  53. mTOR in Growth and Protection of Hypertrophying Myocardium
    Dhandapani Kuppuswamy; Fiscal Year: 2012
    ..augmentation of mTORC2 formation with rapamycin may serve to sustain this compensatory process and improve ventricular function during PO...
  54. Acute and Chronic Regulation of 20S Proteasome Function by cAMP-Dependent Kinase
    SARAH SCRUGGS; Fiscal Year: 2012
    ..b>Ventricular function, morphology, histology, 20S associating partners, and a global phosphorylation profile will be serially ..
  55. The Jefferson Regional Clinical Center for Heart Failure Network
    David J Whellan; Fiscal Year: 2013
    ..prospective phase 2 clinical trial of the effects of SDD in a cohort of 200 HF subjects with reduced left ventricular function. The primary hypothesis is that SDD will significantly reduce left ventricular end diastolic volume index ..
  56. Electro-mechanical Resynchronization Therapy For Arrhythmogenic Right Ventricular
    Harikrishna Tandri; Fiscal Year: 2012
    ..to other disorders, such as forms of congenital heart disease and pulmonary hypertension, where right ventricular function is often affected...
  57. Midcareer Mentoring Award for Patient Oriented Research in Geriatric Cardiology
    Mathew S Maurer; Fiscal Year: 2013
    ..of many extracardiac factors that could contribute to the syndrome of HFNEF, is associated with improved ventricular function, functional capacity and health status...
  58. MESA
    Kiang Liu; Fiscal Year: 2013
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  59. MESA
    Steven Shea; Fiscal Year: 2012
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  60. MESA
    Gregory L Burke; Fiscal Year: 2011
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  61. MESA
    Gregory L Burke; Fiscal Year: 2012
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  62. MESA
    Steven Shea; Fiscal Year: 2010
    ..factors related to progression of subclinical to clinical CVD;(2) identify predictors of decline in ventricular function;(3) further understanding of the basis for racial/ethnic difference in CVD;and (4) provide a platform for ..
  63. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..the continuous beat-by-beat monitoring of wide variety of hemodynamic parameters and multiple indices of ventricular function in order to assess the strength and mechanisms of cardiovascular reflexes at rest and during dynamic ..
  64. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ..means has been conclusively shown to reduce cardiac mortality, less striking beneficial effects on left ventricular function and infarct size reduction have been demonstrated...
  65. MECHANISMS OF MYOCARDIAL REPERFUSION INJURY
    MERVYN FORMAN; Fiscal Year: 1991
    ..Early reperfusion has been shown to reduce infarct size, improve ventricular function, and decrease mortality in the animal model and in man...
  66. Update and modification of Task Force Criteria for ARVD/C
    Frank Marcus; Fiscal Year: 2007
    ..there are no quantitative limits to separate mild from moderate or more severe impairment of global right ventricular function. It is now necessary to eliminate subjective assessment and to define quantitative aspects for the Task ..
  67. ADAPTATIONS TO EXERCISE IN OLDER HYPERTENSIVE SUBJECTS
    Ali Ehsani; Fiscal Year: 2000
    ..3) to determine whether exercise-training can (a) induce regression or reduction of LVH, (b) improve left ventricular function, and (c) reduce arterial stiffness; and (4) to determine whether the training-induced decrease in BP is ..
  68. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2009
    ..Although, current therapies improve left ventricular function, right heart pathologies are not effectively treated...
  69. SURGERY FOR ACUTE MYOCARDIAL INFARCTION
    L Edmunds; Fiscal Year: 2000
    ..regurgitation, left ventricular aneurysm or global left ventricular dilatation with progressive loss of ventricular function occurs...
  70. QUANTITATIVE ULTRASONIC IMAGING FOR MYOCARDIAL VIABILITY
    Julio Perez; Fiscal Year: 1999
    ..disease to allow development of more effective prevention and thereby maintenance of global and segmental ventricular function. In addition, we propose to extend ultrasonic tissue characterization for development of three novel ..
  71. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    Although cell transplant therapy has shown some promise in restoring tissue mass and improving left ventricular function after experimental myocardial infarction, the two major obstacles that must be overcome are 1) having an available ..
  72. QUANTITATIVE VENTRICULOGRAPHY USING DUAL-ENERGY DSA
    MICHAEL VAN LYSEL; Fiscal Year: 1992
    Previous applications of digital subtraction angiography (DSA) to the assessment of ventricular function, particularly during exercise, have been limited by cardiac, respiratory, and gross patient motion...
  73. Cord Blood: Treatment for Acute Myocardial Infarction
    William Marshall; Fiscal Year: 2005
    ..stem cells (hUCBC) has been shown to be effective in limiting infarct size and in the preservation of left ventricular function and anatomy in a rat model...
  74. Oxidative Stress and Nitric Oxide in Aged Myocardium
    ROBERT LASLEY; Fiscal Year: 2005
    ..These factors are thought to play a role in aging-associated decreases in ventricular function, coronary vascular reserve, and tolerance to myocardial ischemia-reperfusion all of which may contribute to ..
  75. CELLULAR MECHANISMS OF AUTOIMMUNE ASSOCIATED CONGENITAL
    Mohamed Boutjdir; Fiscal Year: 1999
    ..An inflammatory phase of cardiac injury has been noted in utero with decreased ventricular function and pericarditis...
  76. RIGHT VENTRICULAR FUNCTION
    WILLIAM SANTAMORE; Fiscal Year: 1991
    ..This maintenance of right ventricular function may be due solely to septal contraction or conceivably, this maintenance of right ventricular function may ..