physiologic neovascularization

Summary

Summary: The development of new BLOOD VESSELS in restoration of BLOOD CIRCULATION during the healing process.

Top Publications

  1. ncbi Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
  2. ncbi Mechanisms of angiogenesis and arteriogenesis
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology KU Leuven, Leuven, B 3000, Belgium
    Nat Med 6:389-95. 2000
  3. ncbi Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
  4. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
  5. ncbi The biology of VEGF and its receptors
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 9:669-76. 2003
  6. ncbi Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors
    Jalees Rehman
    Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Circulation 107:1164-9. 2003
  7. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
  8. ncbi Molecular regulation of vessel maturation
    Rakesh K Jain
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Med 9:685-93. 2003
  9. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
  10. ncbi VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
    Myriam Grunewald
    Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell 124:175-89. 2006

Detail Information

Publications278 found, 100 shown here

  1. ncbi Angiogenesis in life, disease and medicine
    Peter Carmeliet
    Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology VIB, B 3000 Leuven, Belgium
    Nature 438:932-6. 2005
    ..Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments...
  2. ncbi Mechanisms of angiogenesis and arteriogenesis
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology KU Leuven, Leuven, B 3000, Belgium
    Nat Med 6:389-95. 2000
    ....
  3. ncbi Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
    ..Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated...
  4. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
    ..The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell-cell communication...
  5. ncbi The biology of VEGF and its receptors
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 9:669-76. 2003
    ..VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration...
  6. ncbi Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors
    Jalees Rehman
    Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Circulation 107:1164-9. 2003
    ..It is not known whether the proangiogenic effects are a result of such events as endothelial differentiation and subsequent proliferation of EPCs or secondary to secretion of angiogenic growth factors...
  7. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
    ....
  8. ncbi Molecular regulation of vessel maturation
    Rakesh K Jain
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Med 9:685-93. 2003
    ..Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering...
  9. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
    ..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
  10. ncbi VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
    Myriam Grunewald
    Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell 124:175-89. 2006
    ..Together, the data suggest a model for VEGF-programmed adult neovascularization highlighting the essential paracrine role of recruited myeloid cells and a role for SDF1 in their perivascular retention...
  11. ncbi Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
    H U Wang
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 93:741-53. 1998
    ..These results provide evidence that differences between arteries and veins are in part genetically determined and suggest that reciprocal signaling between these two types of vessels is crucial for morphogenesis of the capillary beds...
  12. ncbi Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    Mats Hellstrom
    AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 445:776-80. 2007
    ....
  13. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
    ..Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme...
  14. ncbi Endothelial cells and VEGF in vascular development
    Leigh Coultas
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
    Nature 438:937-45. 2005
    ....
  15. ncbi Endothelial cell migration during angiogenesis
    Laurent Lamalice
    Le Centre de recherche en cancérologie, l Université Laval, L Hôtel Dieu de Québec, Quebec, Canada
    Circ Res 100:782-94. 2007
    ..The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis...
  16. ncbi Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    Shahin Rafii
    Department of Hematology Oncology and Genetic Medicine, Cornell University Medical College, New York, New York, 10021 USA
    Nat Med 9:702-12. 2003
    ..In this review, we discuss the clinical potential of vascular progenitor and stem cells to restore long-lasting organ vascularization and function...
  17. ncbi Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    S Davis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1161-9. 1996
    ..However, its expression in close proximity with developing blood vessels implicates Angiopoietin-1 in endothelial developmental processes...
  18. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
    ..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
  19. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    ..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
  20. ncbi Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
    Eriko Tateishi-Yuyama
    Department of Medicine II and Cardiovascular Centre, Kansai Medical University, Osaka, Japan
    Lancet 360:427-35. 2002
    ..We investigated efficacy and safety of autologous implantation of bone marrow-mononuclear cells in patients with ischaemic limbs because of peripheral arterial disease...
  21. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  22. ncbi Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization
    George E Davis
    Department of Pathology, Texas A and M University System Health Science Center, College Station, USA
    Circ Res 97:1093-107. 2005
    ..Thus, the composition of ECM and therefore the regulation of ECM degradation and remodeling serves pivotally in the control of lumen and tube formation and, finally, neovessel stability and maturation...
  23. ncbi Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors
    J Yamashita
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Nature 408:92-6. 2000
    ..Our findings indicate that Flk1+ cells can act as 'vascular progenitor cells' to form mature vessels and thus offer potential for tissue engineering of the vascular system...
  24. ncbi Role of Akt signaling in vascular homeostasis and angiogenesis
    Ichiro Shiojima
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 90:1243-50. 2002
    ..In this review, Akt signaling in endothelial cells and its critical roles in the regulation of vascular homeostasis and angiogenesis will be discussed...
  25. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
  26. ncbi Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    A A Kocher
    Department of Surgery, Columbia University, New York, New York, USA
    Nat Med 7:430-6. 2001
    ....
  27. ncbi VEGF receptor signalling - in control of vascular function
    Anna Karin Olsson
    Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjöldv 20, 751 85 Uppsala, Sweden
    Nat Rev Mol Cell Biol 7:359-71. 2006
    ..Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease...
  28. ncbi Retinal angiogenesis in development and disease
    Ray F Gariano
    Department of Ophthalmology, A 157, 300 Pasteur Drive, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 438:960-6. 2005
    ..The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases...
  29. pmc Notch signaling is essential for vascular morphogenesis in mice
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 14:1343-52. 2000
    ....
  30. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
    ..Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system...
  31. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
    ..Additional insight into these and other aspects of vascular morphogenesis should be possible through use of NG2 as a mural cell marker...
  32. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  33. pmc The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    Anna Cattelino
    FIRC Institute of Molecular Oncology, 16 20139, Milan, Italy
    J Cell Biol 162:1111-22. 2003
    ..This may become more marked when the vessels are exposed to high or turbulent flow, such as at bifurcations or in the beating heart, leading to fluid leakage or hemorrhages...
  34. ncbi Defective angiogenesis in mice lacking endoglin
    D Y Li
    Program in Human Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5330, USA
    Science 284:1534-7. 1999
    ..Loss of endoglin caused poor vascular smooth muscle development and arrested endothelial remodeling. These results demonstrate that endoglin is essential for angiogenesis and suggest a pathogenic mechanism for HHT1...
  35. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
    ..Given the close relationship between hematopoietic stem cells and endothelial progenitor cells (EPCs), we investigated the effect of SDF-1 on EPC-mediated vasculogenesis...
  36. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    ....
  37. pmc Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
    T Murohara
    Department of Medicine Cardiology and Department of Cardiothoracic Surgery and Biomedical Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Clin Invest 101:2567-78. 1998
    ....
  38. ncbi Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    Arndt F Siekmann
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 445:781-4. 2007
    ..Together, these studies indicate that proper specification of cell identity, position and behaviour in a developing blood-vessel sprout is required for normal angiogenesis, and implicate the Notch signalling pathway in this process...
  39. ncbi Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization
    Bernard Thebaud
    Division of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, Canada
    Circulation 112:2477-86. 2005
    ..Vascular endothelial growth factor (VEGF) is a trophic factor required for endothelial cell survival and is abundantly expressed in the lung...
  40. ncbi Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo
    D Donovan
    Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
    Angiogenesis 4:113-21. 2001
    ..In summary, the morphology of tubules in the Co-culture assay appears more representative of capillary formation in vivo, than the endothelial cell changes that occur in either form of Matrigel assay...
  41. ncbi Matrix metalloproteinases and angiogenesis
    Joyce E Rundhaug
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, TX, 78957, USA
    J Cell Mol Med 9:267-85. 2005
    ..However, because of the multiple effects of MMPs on angiogenesis, careful testing of these MMP inhibitors is necessary to show that these compounds do not actually enhance angiogenesis...
  42. ncbi VEGF is required for growth and survival in neonatal mice
    H P Gerber
    Departments of Cardiovascular Research and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Development 126:1149-59. 1999
    ..Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development...
  43. pmc RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development
    Irit Adini
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genes Dev 17:2721-32. 2003
    ..RhoB may offer a therapeutic target in diseases such as cancer, diabetic retinopathy, and macular degeneration, where the disruption of sprouting angiogenesis would be desirable...
  44. ncbi Molecular and biological properties of vascular endothelial growth factor
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, CA 94080, USA
    J Mol Med (Berl) 77:527-43. 1999
    ..Currently, both therapeutic angiogenesis using recombinant VEGF or VEGF gene transfer and inhibition of VEGF-mediated pathological angiogenesis are being pursued...
  45. ncbi Adipose tissue angiogenesis
    G J Hausman
    USDA ARS, Richard B Russell Agricultural Research Center, Animal Physiology Research Unit, Athens, GA 30605 2720, USA
    J Anim Sci 82:925-34. 2004
    ..Finally, several studies including a study of mice treated with antiangiogenic factors indicate that adipose tissue accretion can be controlled through the vasculature per se...
  46. pmc HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
    S Dimmeler
    Division of Molecular Cardiology, Department of Medicine IV, University of Frankfurt, Frankfurt, Germany
    J Clin Invest 108:391-7. 2001
    ....
  47. ncbi Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: insights from a novel human angiogenesis assay
    Daniel P Sieveking
    Heart Research Institute, Sydney, Australia
    J Am Coll Cardiol 51:660-8. 2008
    ..An endothelial cell (EC)-specific angiogenesis assay was developed to functionally characterize angiogenic properties of 2 distinct putative endothelial progenitor cells (EPCs): early EPCs and late outgrowth endothelial cells (OECs)...
  48. ncbi Angiogenesis in the placenta
    L P Reynolds
    Department of Animal and Range Sciences, and Cell Biology Center, North Dakota State University, Fargo, North Dakota 58105 5727, USA
    Biol Reprod 64:1033-40. 2001
    ..In the future, regulators of angiogenesis that are currently being developed may provide novel and powerful methods to ensure positive outcomes for most pregnancies...
  49. ncbi Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells
    Oren M Tepper
    Laboratory of Microvascular Research and Vascular Tissue Engineering, New York University Medical Center, NY, USA
    Blood 105:1068-77. 2005
    ..We conclude that BM-derived cells produce new blood vessels via localized recruitment, proliferation, and differentiation of circulating cells in a sequence of events markedly different from existing paradigms of angiogenesis...
  50. ncbi SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier
    Sae Won Lee
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nat Med 9:900-6. 2003
    ..Collectively, our results suggest that SSeCKS regulates BBB differentiation by modulating both brain angiogenesis and tight junction formation...
  51. pmc Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
    I B Lobov
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 104:3219-24. 2007
    ..Our data demonstrate that Dll4 is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network...
  52. ncbi Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat
    R A Swain
    Department of Psychology, University of Illinois, 61801, Urbana, IL, USA
    Neuroscience 117:1037-46. 2003
    ..These changes are chronic and observable even in the anesthetized animal and are measurable using noninvasive techniques...
  53. ncbi Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia
    Zheng Gang Zhang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    J Cereb Blood Flow Metab 22:379-92. 2002
    ....
  54. ncbi Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
    Nature 380:439-42. 1996
    ..Angiogenesis and blood-island formation were impaired, resulting in several developmental anomalies. Furthermore, VEGF-null embryonic stem cells exhibit a dramatically reduced ability to form tumours in nude mice...
  55. ncbi Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets
    Marcela Brissova
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Diabetes 53:1318-25. 2004
    ....
  56. ncbi Genes expressed in human tumor endothelium
    B St Croix
    Johns Hopkins Oncology Center, Howard Hughes Medical Institute, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Science 289:1197-202. 2000
    ..These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies...
  57. ncbi Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
    S Giroux
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Pavillon L Hotel Dieu de Quebec, 9, a rue McMahon, Quebec, Canada, G1R 2J6
    Curr Biol 9:369-72. 1999
    ..They also suggest that mek1 function is required for normal response to angiogenic signals that might promote vascularization of the labyrinthine region of the placenta...
  58. pmc Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis
    M Ziche
    Department of Pharmacology, University of Florence, 50134, Florence, Italy
    J Clin Invest 99:2625-34. 1997
    ..Our studies support recent evidence that VEGF and bFGF induce angiogenesis by different mechanistic pathways using the alphavbeta5 and alphavbeta3 integrins, respectively...
  59. ncbi Development and pathology of the hyaloid, choroidal and retinal vasculature
    Magali Saint-Geniez
    Schepens Eye Research Institute, Boston, MA 02114, USA
    Int J Dev Biol 48:1045-58. 2004
    ..The characterization of the molecules and cell-cell interactions involved in the formation, stabilization and regression of new vessels has led to the identification of potential control points for therapeutic intervention...
  60. ncbi Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..This review summarizes the mechanisms regulating endothelial progenitor cell-mediated neovascularization and reendothelialization...
  61. ncbi Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis
    Jonathan D Leslie
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 134:839-44. 2007
    ..Thus, Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf...
  62. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
    ..Together with angiostatin data, these findings validate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therapy...
  63. ncbi Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    S Soker
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:735-45. 1998
    ..We propose that neuropilin-1 is a novel VEGF receptor that modulates VEGF binding to KDR and subsequent bioactivity and therefore may regulate VEGF-induced angiogenesis...
  64. ncbi Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
    T Asahara
    Department of Medicine Cardiology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circ Res 83:233-40. 1998
    ..Moreover, these findings provide in vivo evidence that Ang1 promotes vascular network maturation, whereas Ang2 works to initiate neovascularization...
  65. ncbi Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent cl
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, USA
    Circulation 108:1933-8. 2003
    ....
  66. pmc Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization
    T Murohara
    The Cardiovascular Research Institute, Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    J Clin Invest 105:1527-36. 2000
    ..In conclusion, umbilical cord blood is a valuable source of EPCs, and transplantation of cord blood-derived EPCs represents a promising strategy for modulating postnatal neovascularization...
  67. ncbi Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion
    Junming Tang
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, People s Republic of China
    Eur J Cardiothorac Surg 30:353-61. 2006
    ..The effect of transplanted mesenchymal stem cells (MSCs) on the left ventricular (LV) function and morphology in a rat myocardial infarct heart with reperfusion model were analyzed...
  68. ncbi Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
    D J Dumont
    Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Science 282:946-9. 1998
    ..5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels...
  69. ncbi Vascular endothelial growth factor (VEGF) and its receptors
    G Neufeld
    Department of Biology, Technion, Israel Institute of Technology, Technion City, Haifa 32000, Israel
    FASEB J 13:9-22. 1999
    ....
  70. pmc Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
    D Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:2604-9. 2001
    ..Thus, selective modulation of eNOS activity is a promising strategy for altering angiogenesis and vascular permeability in vivo...
  71. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..These observations suggest that Nrp-1 plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain...
  72. pmc Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors
    Pouneh Kermani
    Division of Hematology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 115:653-63. 2005
    ....
  73. pmc Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
    Rickmer Braren
    The Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, Howard Hughes Medical Institute, San Francisco, CA 94143, USA
    J Cell Biol 172:151-62. 2006
    ..This study reveals that FAK is crucial for vascular morphogenesis and the regulation of EC survival and morphology...
  74. ncbi The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis
    Timothy D Henry
    Division of Cardiology at Hennepin County Medical Center and University of Minnesota, Minneapolis, USA
    Circulation 107:1359-65. 2003
    ..VIVA (Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis) is a double-blind, placebo-controlled trial designed to evaluate the safety and efficacy of intracoronary and intravenous infusions of rhVEGF...
  75. ncbi Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
    Alexandra Aicher
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Med 9:1370-6. 2003
    ..This may contribute to impaired regeneration processes in ischemic heart disease patients, who are characterized by a reduced systemic NO bioactivity...
  76. ncbi Angiogenesis and bone repair
    Richard A D Carano
    Department of Physiology, Genentech, 1 DNA Way MS 42, South San Francisco, CA 94080, USA
    Drug Discov Today 8:980-9. 2003
    ..In this review, the role of osteogenic factors in the adaptive response and interactive function of OB and EC during the multi-step process of bone repair will be discussed...
  77. pmc Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells
    Emmanouil Chavakis
    Molecular Cardiology, Dept of Medicine III, University of Frankfurt, 60950 Frankfurt, Germany
    J Exp Med 201:63-72. 2005
    ..Preactivation of the beta2-integrins expressed on EPCs by activating antibodies augments the EPC-induced neovascularization in vivo. These results provide evidence for a novel function of beta2-integrins in postnatal vasculogenesis...
  78. ncbi Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1
    Martin N Nakatsu
    Department of Molecular Biology and Biochemistry, 3219 McGaugh Hall, University of California, Irvine, Irvine, CA 92697, USA
    Microvasc Res 66:102-12. 2003
    ..This improved model recapitulates all the major steps of angiogenesis seen in vivo and provides a powerful model for analysis of this complex phenomenon...
  79. pmc Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
    Clare R Ozawa
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    J Clin Invest 113:516-27. 2004
    ..Long-term continuous delivery of VEGF, when maintained below a threshold microenvironmental level, can lead to normal angiogenesis without other exogenous growth factors...
  80. ncbi Does adult fracture repair recapitulate embryonic skeletal formation?
    C Ferguson
    Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Ave, San Francisco, USA
    Mech Dev 87:57-66. 1999
    ..Taken together, these data suggest the genetic mechanisms regulating fetal skeletogenesis also regulate adult skeletal regeneration, and point to important regulators of angiogenesis and ossification in bone regeneration...
  81. ncbi Endothelial progenitor cells
    Aarif Y Khakoo
    National Institutes of Health, National Heart, Lung, and Blood Institute, Cardiovascular Branch, Laboratory of Molecular Biology, Bethesda, Maryland 21284, USA
    Annu Rev Med 56:79-101. 2005
    ..We review experimental results obtained from both animal studies and recent clinical trials that suggest this cell type may have tremendous therapeutic potential for a wide range of human diseases...
  82. pmc Modeling the early stages of vascular network assembly
    Guido Serini
    Institute for Cancer Research and Treatment and Department of Oncological Sciences, University of Torino, 10060 Candiolo To
    EMBO J 22:1771-9. 2003
    ..We propose a mechanism linking the scale of formed endothelial structures to the range of cell-to-cell interaction mediated by the release of chemoattractants...
  83. ncbi Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases
    Beate Heissig
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York, USA
    Curr Opin Hematol 10:136-41. 2003
    ....
  84. ncbi Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis
    Marcus Fruttiger
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    Invest Ophthalmol Vis Sci 43:522-7. 2002
    ..These cells are alleged to be vascular precursor cells (angioblasts). This study was designed to test whether such angioblasts exist in neonatal mouse retina...
  85. pmc WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
    Ivan B Lobov
    Division of Developmental Biology, The Children s Hospital Research Foundation and Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Nature 437:417-21. 2005
    ..These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions--including cell death--in adjacent cells, and raise the possibility that they do so in many different cellular contexts...
  86. ncbi Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo
    Giuseppina Cantarella
    Department of Experimental and Clinical Pharmacology, University of Catania School of Medicine, I 95125 Catania, Italy
    FASEB J 16:1307-9. 2002
    ..Unraveling mechanisms of NGF-dependent angiogenesis could provide valuable tools for novel therapeutic approaches in antiangiogenic therapy...
  87. pmc A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular development
    Claudia O Rodrigues
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Development 135:1903-11. 2008
    ..Collectively, these findings support a model in which Myc, Twist and Slug/Snail2 function in a regulatory circuit within lateral plate mesoderm that directs normal vessel formation in both the vascular and lymphatic systems...
  88. pmc Role of specific microRNAs for endothelial function and angiogenesis
    Fusheng Wu
    Department of Neurosurgery and Physiology, LSU Health Science Center, Shreveport, LA 71130, USA
    Biochem Biophys Res Commun 386:549-53. 2009
    ..In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis...
  89. ncbi Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 43:3500-10. 2002
    ..Since most diseases that cause catastrophic loss of vision do so as a result of abnormal ocular angiogenesis, a better understanding of events regulating normal retinal vascular growth may provide insight into pathologic angiogenesis...
  90. ncbi Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration
    Benedetta Bussolati
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, B12 2TG, United Kingdom
    Blood 103:761-6. 2004
    ....
  91. pmc Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
    J Xu
    Department of Radiation Oncology, Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 154:1069-79. 2001
    ..Together, these studies suggest a novel mechanism by which proteolysis contributes to angiogenesis by exposing hidden regulatory elements within matrix-immobilized collagen type IV...
  92. ncbi Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis
    Raghu Adya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 78:356-65. 2008
    ..We therefore investigated the effect of visfatin on vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) production and the potential signalling cascades...
  93. ncbi Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle
    Feilim Mac Gabhann
    Dept of Biomedical Engineering, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, 613 Traylor Bldg, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 292:H459-74. 2007
    ..This model is the first to study VEGF tissue distribution and receptor activation in human muscle, and it provides a platform for the design and evaluation of therapeutic approaches...
  94. pmc Endothelial progenitor cells in neovascularization of infarcted myocardium
    Kentaro Jujo
    Feinberg Cardiovascular Research Institute, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Mol Cell Cardiol 45:530-44. 2008
    ..To optimize therapeutic outcomes, researchers must continue to refine methods of EPC purification, expansion, and administration, and to develop techniques that overcome the intrinsic scarcity and phenotypic deficiencies of EPCs...
  95. ncbi Intussusceptive angiogenesis: its role in embryonic vascular network formation
    V Djonov
    Institute of Anatomy, University of Berne, Switzerland
    Circ Res 86:286-92. 2000
    ....
  96. ncbi Molecular angiogenesis
    M Klagsbrun
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chem Biol 6:R217-24. 1999
    ..Angiogenesis-stimulating factors are being used to promote growth of new blood vessels in ischemic disease. In contrast, anti-angiogenesis factors are being used as inhibitors of neovascularization to control tumor growth and metastasis...
  97. ncbi Angiogenesis and vascular remodelling in normal and cancerous tissues
    Markus R Owen
    School of Mathematical Sciences, University of Nottingham, Nottingham, UK
    J Math Biol 58:689-721. 2009
    ..This can lead to metastable periods, during which the tumour burden is approximately constant, followed by periods of rapid growth...
  98. pmc NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation
    Jian xiong Chen
    Department of Pediatrics, Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    Am J Physiol Heart Circ Physiol 292:H1664-74. 2007
    ..Our findings underscore the important role of NADPH oxidase and its subunit p47(phox) in modulating Akt and ERK1/2 activation, angiogenic growth factor expression, and angiogenesis in myocardium undergoing I/R...
  99. ncbi Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia
    Masahiro Kajiguchi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
    Circ J 71:196-201. 2007
    ..However, because one-third of treated patients fail to respond, the present study was an exploration of the characteristics of responders and non-responders to this treatment regimen...
  100. pmc CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue
    Yubin Shi
    Department of Pathology C3321 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2562, USA
    Am J Pathol 166:303-12. 2005
    ..These findings indicate that CARP could play a unique role in therapeutic angiogenesis during wound healing...
  101. ncbi Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members
    Vidya Limaye
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Blood 105:3169-77. 2005
    ....

Research Grants62

  1. Sphingosine 1-phosphate receptors in vascular homeostasis and pathology
    TIMOTHY TUN HLA; Fiscal Year: 2012
    ..These studies are expected to derive critical insights into the workings of S1P receptors, which are important drug targets to control the vascular and immune systems. ..
  2. MiR-26a, endothelial cells, and neovascularization
    Mark W Feinberg; Fiscal Year: 2013
    ....
  3. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2013
    ....
  4. Living Delivery Systems to Promote Vascular Development in 3D Scaffolds
    James Blanchette; Fiscal Year: 2013
    ..This marker correlates well with other methods of tracking HIF-1 activity and represents a novel, enabling technology to further analysis of hypoxia within tissue engineering scaffolds. ..
  5. Caveolin-2 and Endothelial Cell Function
    Grzegorz Sowa; Fiscal Year: 2012
    ..Thus, understanding the molecular mechanisms controlling angiogenesis is of key significance. The knowledge gained from this research will facilitate the treatment of cardiovascular and pulmonary disease, injuries, and cancer. ..
  6. Combination immunotherapies for the treatment of melanoma
    Michael W Fanger; Fiscal Year: 2013
    ....
  7. Heparan sulfate proteoglycan interacts with Slit/Robo to regulate angiogenesis
    Lianchun Wang; Fiscal Year: 2013
    ..The structural features of Slit3/Robo-binding HS fragments will be deduced by size and composition analyses in conjunction with HS analogs. ..
  8. The role of signaling molecule AIP1 in pathological angiogenesis
    Wang Min; Fiscal Year: 2013
    ..We will test the potential therapeutic effects of AIP1-derived peptides in these models. ..
  9. ACTIVE TUMOR IMMUNOTHERAPY TARGETING THE VEGF RECEPTOR
    Yiwen Li; Fiscal Year: 2000
    ..The overall market for a successful anti- angiogenesis therapy that inhibits tumor growth will potentially be very large, since it likely will include many human carcinomas. ..
  10. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ..abstract_text> ..
  11. Slit/Robo Signaling and Placental Angiogenesis
    WUXIANG LIAO; Fiscal Year: 2009
    ..The proposed studies will lay the foundation of our understanding of how neuronal guidance factors like Slit/Robo take part in the regulation of placenta function, especially on placental angiogenesis. ..
  12. Wnt Function in Angiogenesis and Vascular Development
    Jan Kitajewski; Fiscal Year: 2009
    ..These studies will define how aberrant Wnt/Frizzled signaling might contribute to vascular pathologies and diseases, such as familial exuditive vitreoretinopathy. ..
  13. Age, VEGF, and skeletal muscle capillarization in humans
    TIMOTHY GAVIN; Fiscal Year: 2003
    ..Data obtained from these studies will provide necessary information for future R01 funding. Findings will be important as little is known concerning the effects of aging on neovascularization potential in humans. ..
  14. Angiogenesis:Novel Basic Science Insight & Human Therapy
    Napoleone Ferrara; Fiscal Year: 2004
    ..abstract_text> ..
  15. Neurorestorative Therapy of Stroke with Statins
    Jieli Chen; Fiscal Year: 2007
    ..This study provides a new and highly effective way to treat stroke and may permit translation our finding of restorative therapeutic benefit of statin in experimental stroke to the patient. ..
  16. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  17. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  18. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2007
    ..This raises a significant broad-based issue of controlling ambient O2 during cell culture. Finally, an isolated cell culture model to study chronic moderate hypoxia followed by reoxygenation is offered. ..
  20. In vivo Dynamic Imaging of Angiogenesis in Transplanted Islets
    Eba Hathout; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. CSF-1, MACROPHAGES AND MALE REPRODUCTIVE FUNCTION
    Jeffrey Pollard; Fiscal Year: 2001
    ..This should significantly enhance our understanding of some aspects of human infertility and will provide important insight into the mechanism by which infection can affect fertility in healthy human males. ..
  22. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..This knowledge base may provide a rationale for developing peripherally-selective cannabinoid analgesics with minimal CNS-mediated side-effect liability. ..
  23. Mechanisms of Nicotine Induced Neurogenic Inflammation
    Kenneth Hargreaves; Fiscal Year: 2005
    ....
  24. Function of CMG-2, an Anthrax Toxin Receptor
    George Davis; Fiscal Year: 2005
    ..Specific Aim #2. To identify CMG-2 co-receptors, such as integrins, which are involved in its ability to regulate protective antigen binding, proteolytic processing and internalization. ..
  25. MECHANISMS OF ANGIOGENESIS IN TRANSGENIC TUMORIGENESIS
    Judah Folkman; Fiscal Year: 2004
    ..4. Further develop experimental therapeutic approaches that utilize angiogenesis inhibitors for treatment or prevention of endogenous cancers in transgenic mouse models. ..
  26. Cannabinoid Modulation of Capsaicin-Sensitive Nociceptors
    Kenneth M Hargreaves; Fiscal Year: 2010
    ..Second, identification of cannabinoid modulation of pain via TRPchannels provides a rationale for a novel class of analgesics that are devoid of classical cannabinoid side effects. ..
  27. ENDOTHELIAL CELL ROLE IN YOLK SAC STEM CELL DEVELOPMENT
    Mervin Yoder; Fiscal Year: 2008
    ..These studies will define molecular pathways required for blood island development and remodeling. ..
  28. Progesterone Action in the Uterus of Mice and Humans
    Jeffrey Pollard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. ANGIOGENIC THERAPY FOR INFARCTED AND ISCHEMIC HEART
    Robert Tomanek; Fiscal Year: 2003
    ..Such interventions have a number of advantages over more invasive interventions, e.g., the delivery of oxogenous growth factors or gene therapy. ..
  31. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  32. Mechanism of Myocardial Angiogenesis in Transgenic/Knockout Animals
    Nilanjana Maulik; Fiscal Year: 2010
    ..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
  33. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2010
    ..The current proposal will identify a novel mediator, leukocyte-derived MPO, in neointima formation and its molecular mechanism(s). Blocking the MPO pathway might be a new therapeutic approach to restenosis after balloon angioplasty. ..
  34. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2010
    ..abstract_text> ..
  35. Signal-transduction of Endothelial nAChR in Angiogenesis
    John Cooke; Fiscal Year: 2008
    ....
  36. Genetic Determinants of PAD
    John Cooke; Fiscal Year: 2007
    ..Sinai and Stanford University which has extensive expertise in cell and vascular biological studies, integrative physiology, human genomic and genetic studies, epidemiology and clinical trials in PAD. ..
  37. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  38. Cardiac Disease and Regeneration
    Stefanie Dimmeler; Fiscal Year: 2005
    ..As aging is a major risk factor for cardiovascular disease a special session will focus on the molecular determinants of aging and its role in cardiac diseases. ..
  39. Cord Blood Stem Cell Expansion Ex Vivo With Endothelial Progenitor Cells
    Mervin Yoder; Fiscal Year: 2005
    ..abstract_text> ..
  40. MANIPULATION OF THE NOS PATHWAY IN ARTERIAL DISEASE
    John Cooke; Fiscal Year: 2004
    ..These studies may lead to a novel and cost-effective strategy for treatment of peripheral arterial disease. ..
  41. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..abstract_text> ..
  42. EINSTEIN TRANSGENIC AND GENE TARGETING COURSE
    Jeffrey Pollard; Fiscal Year: 2004
    ..Considerable emphasis in placed upon these interactions so that experimental procedures can be developed by the students in the future that address specific human diseases particularly cancer. ..
  43. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ....
  44. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  45. Conference--Wound Healing : O2 and Emerging Therapeutics
    Chandan Sen; Fiscal Year: 2002
    ..Oxygen Sensing Oxidant Signaling & Redox Regulated Gene Expression Oxygen Therapy of Wounds Potential and Limitations of Clinical Gene Therapy for Wound Care Wound Angiogenesis Inflammation and Bacterial Control Clinical Care ..
  46. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2006
    ..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..
  47. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2006
    ..Understanding the mechanistic basis of the macrophage enhancement of metastasis could result in the development of novel therapeutics aimed at to prevent this step. ..
  48. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
  49. ADMA: An endogenous inhibitor of ESC differentiation and EC regeneration
    John Cooke; Fiscal Year: 2007
    ..This proposal will provide fundamental insights regarding the use of ESC- derived EC for endothelial regeneration, with specific attention to therapeutic angiogenesis, and its regulation by NOS. [unreadable] [unreadable] [unreadable]..
  50. Stanford Vascular Biology and Medicine Training Grant
    John Cooke; Fiscal Year: 2007
    ..abstract_text> ..
  51. Regulation of Coronary Vessel Assembly and Growth
    Robert Tomanek; Fiscal Year: 2007
    ..Since cardiac development depends on timely and adequate vascularization, an understanding of coronary vasculogenesis and angiogenesis will provide an important foundation for our understanding of cardiac defects. ..
  52. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Functional role of Angiopoietin-2 in diabetic heart
    Jian xiong Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. Neuropeptide Y Regulation of Peripheral Human Nociceptors and Pain
    Kenneth Hargreaves; Fiscal Year: 2007
    ..Moreover, our study population in South Texas permits secondary analyses of a potentially underserved population (predominantly Hispanic) that is at risk for caries-induced pulpal necrosis and pain. [unreadable] [unreadable]..
  55. 2006 Reproductive Tract Biology Gordon Research Conference
    Jeffrey Pollard; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  56. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2010
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine the inflammatory cytokines and cells responsible for new vessel growth, and pharmacological and interventional inhibitors. ..
  57. LAMININ-8 AND LAMININ-10 IN SQUAMOUS CELL CARCINOMAS
    Jie Li; Fiscal Year: 2009
    ....
  58. Regulatory elements controlling elastin transcription
    Richard Pierce; Fiscal Year: 2005
    ..These approaches will reveal key mechanisms controlling elastin synthesis and identify targets for strategies to modulate elastin synthesis in the lungs of premature infants and in pulmonary emphysema. ..
  59. Chemokine Modulation of Endothelial Cell Behavior
    Richard Bodnar; Fiscal Year: 2005
    ..This study will provide potential new targets to promote or limit vascular development in tissue and contribute to our ability to engineer tissues with appropriate microvasculature. ..
  60. Regulation of osteoblast function by endothelin-1
    Gregory Clines; Fiscal Year: 2006
    ..Since sex steroids modulate the effects of ETA blockade, eugonadal and castrated mice will be analyzed for gross anatomic and histologic bone developmental abnormalities. [unreadable] [unreadable]..
  61. MOLECULAR PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Lewis Roberts; Fiscal Year: 2008
    ..Successful completion of these studies will provide insight into the molecular pathogenesis of HCC, and may lead to the development of novel chemotherapeutic strategies against HCC. ..
  62. Novel Class of Phospholipases-Molecular Pathogenesis
    Michael Vasil; Fiscal Year: 2007
    ..Furthermore, it is likely that information we derive from our efforts will also provide additional insights about the biochemistry and biology of PLCs in general. ..