systole

Summary

Summary: Period of contraction of the HEART, especially of the HEART VENTRICLES.

Top Publications

  1. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
  2. ncbi Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction
    Zoran B Popovic
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 292:H2809-16. 2007
  3. ncbi Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
  4. ncbi Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance
    Alicia M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 27:2879-88. 2006
  5. ncbi Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function
    Marina Leitman
    Cardiology Department, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    J Am Soc Echocardiogr 17:1021-9. 2004
  6. ncbi Pulmonary regurgitation is an important determinant of right ventricular contractile dysfunction in patients with surgically repaired tetralogy of Fallot
    A Frigiola
    Grown up Congenital Heart Unit, The Heart Hospital, Westmoreland Street, London, UK
    Circulation 110:II153-7. 2004
  7. ncbi Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure
    S Ghio
    Dipartimento di Cardiologia, IRCCS Policlinico S Matteo, Pavia, Italy
    J Am Coll Cardiol 37:183-8. 2001
  8. ncbi Age- and gender-related ventricular-vascular stiffening: a community-based study
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Circulation 112:2254-62. 2005
  9. ncbi Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart disease
    Mehdi H Shishehbor
    Department of Internal Medicine, Cardiovascular Imaging Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Cardiol 91:1514-7, A9. 2003
  10. ncbi The duration of systole in an electrocardiogram in normal humans and in patients with heart disease. 1920
    L S Fridericia
    Ann Noninvasive Electrocardiol 8:343-51. 2003

Detail Information

Publications326 found, 100 shown here

  1. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  2. ncbi Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction
    Zoran B Popovic
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 292:H2809-16. 2007
    ..0001) than on percent fibrosis (P<0.002). STE correctly identifies segmental LV dysfunction induced by scarring that follows myocardial infarction in rats...
  3. ncbi Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
    ..Further, diastolic function is seldom systematically assessed based on standardized techniques...
  4. ncbi Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance
    Alicia M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 27:2879-88. 2006
    ..We used these techniques to establish the reference values for right ventricular (RV) volumes and function...
  5. ncbi Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function
    Marina Leitman
    Cardiology Department, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    J Am Soc Echocardiogr 17:1021-9. 2004
    ..We sought to assess the feasibility of 2-dimensional strain, a novel software for real-time quantitative echocardiographic assessment of myocardial function...
  6. ncbi Pulmonary regurgitation is an important determinant of right ventricular contractile dysfunction in patients with surgically repaired tetralogy of Fallot
    A Frigiola
    Grown up Congenital Heart Unit, The Heart Hospital, Westmoreland Street, London, UK
    Circulation 110:II153-7. 2004
    ..Evaluation of right ventricular (RV) function in patients with pulmonary regurgitation (PR) after tetralogy repair remains challenging because of abnormal RV loading conditions...
  7. ncbi Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure
    S Ghio
    Dipartimento di Cardiologia, IRCCS Policlinico S Matteo, Pavia, Italy
    J Am Coll Cardiol 37:183-8. 2001
    ..We sought a better understanding of the coupling between right ventricular ejection fraction (RVEF) and pulmonary artery pressure (PAP), as it might improve the accuracy of the prognostic stratification of patients with heart failure...
  8. ncbi Age- and gender-related ventricular-vascular stiffening: a community-based study
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Circulation 112:2254-62. 2005
    ..The prevalence of HFnlEF increases strikingly with age, particularly in women. We hypothesized that ventricular-vascular stiffening may occur with age and be more pronounced in women in the general community...
  9. ncbi Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart disease
    Mehdi H Shishehbor
    Department of Internal Medicine, Cardiovascular Imaging Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Cardiol 91:1514-7, A9. 2003
  10. ncbi The duration of systole in an electrocardiogram in normal humans and in patients with heart disease. 1920
    L S Fridericia
    Ann Noninvasive Electrocardiol 8:343-51. 2003
  11. ncbi Cardiac systolic rotation and contraction before and after valve replacement for aortic stenosis: a myocardial tagging study using MR imaging
    Joern J W Sandstede
    Institut für Röntgendiagnostik and Medizinische Klinik, Universitat Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    AJR Am J Roentgenol 178:953-8. 2002
    ....
  12. ncbi Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    Margaret M Redfield
    Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 9, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    JAMA 289:194-202. 2003
    ..Yet, the prevalence of diastolic dysfunction and its relation to systolic dysfunction and CHF in the community remain undefined...
  13. ncbi Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance
    A M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 8:417-26. 2006
    ..These novel data have particular importance for clinical practice and clinical trials using CMR...
  14. ncbi A finite element model of the human left ventricular systole
    F Dorri
    Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH 8092, Zurich, Switzerland
    Comput Methods Biomech Biomed Engin 9:319-41. 2006
    ..aimed at an analysis and functional interpretation of the deformation pattern of an exemplary human heart at end-systole. To this end, the finite element (FE) method was used to simulate the three-dimensional deformations of the left ..
  15. ncbi Clinical implication of mitral annular plane systolic excursion for patients with cardiovascular disease
    Kai Hu
    Department of Internal Medicine I, Comprehensive Heart Failure Center, University of Wurzburg, Oberdürrbacher Str 6, 97080 Wurzburg, Germany
    Eur Heart J Cardiovasc Imaging 14:205-12. 2013
    ....
  16. ncbi Cardiac mechanics in mild hypertensive heart disease: a speckle-strain imaging study
    Arumugam Narayanan
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Circ Cardiovasc Imaging 2:382-90. 2009
    ..The aim of the current case-control study was to use speckle tracking imaging to identify subclinical global and regional systolic function abnormalities in hypertensive subjects with normal ejection fraction...
  17. ncbi Impact of systolic time intervals on the relationship between arterial stiffness and left ventricular hypertrophy
    Ho Ming Su
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan
    Atherosclerosis 223:171-6. 2012
    ....
  18. ncbi Influence of the pattern of hypertrophy on left ventricular twist in hypertrophic cardiomyopathy
    B M Van Dalen
    Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Heart 95:657-61. 2009
    ..The influence of the pattern of LV hypertrophy on LV twist in hypertrophic cardiomyopathy (HCM) patients is unknown. This study sought to assess LV twist in a large group of HCM patients according to the pattern of LV hypertrophy...
  19. ncbi Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure
    Minoru Yambe
    Second Department of Internal Medicine, Tokyo Medical University, Japan
    Hypertens Res 27:625-31. 2004
    ..Therefore, increased arterial stiffness is a possible simultaneous risk for atherosclerotic cardiovascular disease and diastolic heart failure in patients with hypertension...
  20. pmc Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure
    N Wisniacki
    Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK
    Heart 91:32-7. 2005
    ..To evaluate insulin resistance and systemic inflammation in older patients with systolic (SHF) or diastolic heart failure (DHF)...
  21. ncbi Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 375:895-905. 2010
    ..We aimed to reliably establish the prognostic significance of visit-to-visit variability in blood pressure, maximum blood pressure reached, untreated episodic hypertension, and residual variability in treated patients...
  22. ncbi Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair
    Judith Therrien
    Toronto Congenital Cardiac Centre for Adults, Toronto, Ontario, Canada
    Am J Cardiol 95:779-82. 2005
    ..12). In no patients with a RV end-diastolic volume >170 ml/m2 or a RV end-systolic volume >85 ml/m2 before pulmonary valve replacement were RV volumes "normalized" after surgery...
  23. ncbi A clinician's guide to tissue Doppler imaging
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e396-8. 2006
  24. ncbi Flow mediated dilatation and cardiac function in type 1 diabetes mellitus
    Bharati Shivalkar
    Department of Cardiology, University Hospital Antwerp, Edegem, Belgium
    Am J Cardiol 97:77-82. 2006
    ..In conclusion, FMD is associated with abnormal segmental cardiac function in type 1 DM...
  25. ncbi Comparison of changes in ejection fraction to changes in impedance cardiography cardiac index and systolic time ratio
    Charles W Parrott
    Cardiology Associates of Mobile, Providence Hospital, Heart Failure Clinic, Mobile, AL 36608, USA
    Congest Heart Fail 10:11-3. 2004
    ..85, -0.73). ICG may be a practical, reliable, and cost-effective method of monitoring left ventricular function and guiding management decisions...
  26. ncbi Tissue Doppler echocardiography in persons with hypertension, diabetes, or ischaemic heart disease: the Copenhagen City Heart Study
    Rasmus Mogelvang
    Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    Eur Heart J 30:731-9. 2009
    ..To test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) in the general population...
  27. ncbi Mechanism of dynamic regurgitant orifice area variation in functional mitral regurgitation: physiologic insights from the proximal flow convergence technique
    J Hung
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston 02114, USA
    J Am Coll Cardiol 33:538-45. 1999
    ..We used the Doppler proximal flow convergence technique as a physiologic tool to explore the effects of the time courses of mitral annular area and transmitral pressure on dynamic changes in regurgitant orifice area...
  28. ncbi Lower systolic blood pressure is associated with greater mortality in people aged 85 and older
    Lena Molander
    Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umea University, Umea, Sweden
    J Am Geriatr Soc 56:1853-9. 2008
    ..To investigate the association between blood pressure and mortality in very old people...
  29. pmc Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions
    James West
    Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 295:L744-55. 2008
    ..This model should be useful to the research community in examining early molecular and physical events in the development of PAH and as a platform to validate potential treatments...
  30. ncbi Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation
    John P Konhilas
    Department of Physiology and Biophysics, and Cardiovascular Sciences Program, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Pflugers Arch 445:305-10. 2002
  31. ncbi Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life
    Shumei S Sun
    Lifespan Health Research Center, Department of Community Health, Wright State University Boonshoft School of Medicine, 3171 Research Blvd, Dayton, OH 45420, USA
    Pediatrics 119:237-46. 2007
    ....
  32. ncbi Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy
    Ricardo H Pignatelli
    Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children s Hospital, 6621 Fannin, Houston 77030, Tex, USA
    Circulation 108:2672-8. 2003
    ..The purpose of this study was to identify the clinical characteristics of children with LVNC...
  33. ncbi Television time and continuous metabolic risk in physically active adults
    Genevieve N Healy
    School of Population Health, University of Queensland, Brisbane, Australia
    Med Sci Sports Exerc 40:639-45. 2008
    ..Among Australian adults who met the public health guideline for the minimum health-enhancing levels of physical activity, we examined the dose-response associations of television-viewing time with continuous metabolic risk variables...
  34. ncbi Results of the pilot study for the Hypertension in the Very Elderly Trial
    Christopher J Bulpitt
    Faculty of Medicine, Imperial College London, UK
    J Hypertens 21:2409-17. 2003
    ..The risks and benefits of treating hypertension in individuals older than 80 years are uncertain. A meta-analysis has suggested that a reduction in stroke events of 36% may have to be balanced against a 14% increase in total mortality...
  35. ncbi Mitral annular plane systolic excursion on exercise: a simple diagnostic tool for heart failure with preserved ejection fraction
    Frauke W G Wenzelburger
    Department of Cardiovascular Medicine, University of Birmingham, Birmingham, UK
    Eur J Heart Fail 13:953-60. 2011
    ..We hypothesized that Mitral annular plane systolic excursion (MAPSE) which is easy to acquire on exercise could be used to detect occult left ventricular (LV) impairment...
  36. pmc Cardiac filling volumes versus pressures for predicting fluid responsiveness after cardiovascular surgery: the role of systolic cardiac function
    Ronald J Trof
    Vrije Universiteit Medical Centre, Department of Intensive Care, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Crit Care 15:R73. 2011
    ....
  37. ncbi Role of radial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overload
    Kaoru Dohi
    Mie University Graduate School of Medicine, Tsu, Japan
    Am J Cardiol 101:1206-12. 2008
    ....
  38. ncbi Left ventricular systolic and diastolic function by echocardiogram in pseudoxanthoma elasticum
    Long Dang Nguyen
    Department of Cardiology, centre hospitalier régional d Orléans, Orleans, France
    Am J Cardiol 97:1535-7. 2006
    ..Explanations for these abnormalities could be silent myocardial ischemia due to early coronary involvement and/or the direct consequences of ultrastructural defects of the elastic tissue of the heart...
  39. ncbi Tissue Doppler imaging in the left ventricle and right ventricle in healthy children: normal age-related peak systolic velocities, timings, and time differences
    Annelies E van der Hulst
    Division of Pediatric Cardiology, Department of Pediatrics, J6 S Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Echocardiogr 12:953-60. 2011
    ..Knowledge on normal age-related values of peak systolic velocities and timings in healthy children may optimize the benefit of device-based therapies in paediatric patients with heart failure...
  40. ncbi A study on polymorphisms of elastin gene in Chinese Han patients with isolated systolic hypertension
    Liehua Deng
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Am J Hypertens 22:656-62. 2009
    ..Recent studies have shown that polymorphism of ELN is associated with stiffness of elastic arteries and elevated blood pressure; however, there are no further studies on isolated systolic hypertension (ISH)...
  41. ncbi Left ventricular myocardial velocities and deformation indexes in top-level athletes
    Antonello D'Andrea
    Second University of Naples, Monaldi Hospital Naples, Naples, Italy
    J Am Soc Echocardiogr 23:1281-8. 2010
    ..The aim of this study was to define the range of left ventricular (LV) velocities and deformation indexes in highly trained athletes, analyzing potential differences induced by different long-term training protocols...
  42. pmc Age, increased left ventricular mass, and lower regional myocardial perfusion are related to greater extent of myocardial dyssynchrony in asymptomatic individuals: the multi-ethnic study of atherosclerosis
    Boaz D Rosen
    Division of Cardiology, Department of Medicine, Blalock 524, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287 0409, USA
    Circulation 120:859-66. 2009
    ..Our goal was to study the relationships of LV mass and age with myocardial dyssynchrony among asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis...
  43. ncbi Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 34:594-9. 2003
    ..Elevated blood pressure has been found to increase the risk of dementia, including Alzheimer disease. We sought to investigate whether pulse pressure was predictive of Alzheimer disease and dementia...
  44. ncbi Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus
    D Westermann
    Department of Cardiology and Pneumology, Charite University Hospital, Benjamin Franklin Campus, Berlin, Germany
    Diabetologia 49:2507-13. 2006
    ..We investigated the effect of SB 203580, a pharmacological inhibitor of p38 mitogen-activated protein kinase (MAPK), on cardiac inflammation, cardiac fibrosis, and left ventricular function using an animal model of diabetic cardiomyopathy...
  45. ncbi Imaging the right ventricle--current state of the art
    Luc L Mertens
    The Labatt Family Heart Center, Division of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Cardiol 7:551-63. 2010
    ....
  46. ncbi Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) study
    V Palmieri
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Circulation 103:102-7. 2001
    ..It remains to be elucidated in a large, population-based sample whether diabetes is associated with changes in left ventricular (LV) structure and systolic function independent of obesity and systolic blood pressure (BP)...
  47. ncbi A piezo-film-based measurement system for global haemodynamic assessment
    Fabrizio Clemente
    Istituto di Ingegneria, Biomedica Consiglio Nazionale delle Ricerch, Via Salaria Km 29, 300 00016 Monterotondo S RM, Italy
    Physiol Meas 31:697-714. 2010
    ..The system was characterized by numerical simulation and experimental in vivo comparison to the traditional reference system...
  48. ncbi Mitral annular plane systolic excursion as a surrogate for left ventricular ejection fraction
    Jason Matos
    Non invasive Cardiology, Lenox Hill Hospital, North Shore LIJ Health System, New York, New York, USA
    J Am Soc Echocardiogr 25:969-74. 2012
    ..The aim of this study was to examine the accuracy of MAPSE for predicting left ventricular ejection fraction (EF) on the basis of a large cohort of consecutive echocardiograms...
  49. pmc Cardiac cine MRI: Quantification of the relationship between fast gradient echo and steady-state free precession for determination of myocardial mass and volumes
    Ashkan Akhavan Malayeri
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Magn Reson Imaging 28:60-6. 2008
    ..To determine the correlation function between the steady-state free precession (SSFP) and fast gradient echo (FGRE) cine MRI pulse sequences for measuring the myocardial mass and volumes...
  50. pmc Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy
    Scott J Denardo
    Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Med 123:719-26. 2010
    ..Our understanding of the growing population of very old patients (aged >or=80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes...
  51. ncbi Impact of arterial load and loading sequence on left ventricular tissue velocities in humans
    Barry A Borlaug
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 50:1570-7. 2007
    ..The aim of this study was to examine the relationship between individual components of left ventricular (LV) afterload and tissue Doppler echocardiography (TDE) velocities in humans...
  52. ncbi The systolic to diastolic duration ratio in children with hypoplastic left heart syndrome: a novel Doppler index of right ventricular function
    Mark K Friedberg
    Division of Pediatric Cardiology, Department of Pediatrics, Lucille Packard Children s Hospital and Stanford University, Stanford, California, USA
    J Am Soc Echocardiogr 20:749-55. 2007
    ..However, assessment of RV function remains challenging because of its complex morphology. We investigated the S/D duration ratio in children with HLHS as a novel index of global RV function...
  53. ncbi Physiologic compensation is supranormal in compensated aortic stenosis: does it return to normal after aortic valve replacement or is it blunted by coexistent coronary artery disease? An intramyocardial magnetic resonance imaging study
    Robert W W Biederman
    Center for Cardiovascular Magnetic Resonance Imaging, Division of Cardiology, Department of Surgery, Allegheny General Hospital, Pittsburgh, PA, USA
    Circulation 112:I429-36. 2005
    ..We investigated intramyocardial mechanics after aortic valve replacement (AVR) and the effects relative to the presence or absence of coronary artery disease (CAD+ or CAD-), respectively...
  54. ncbi A systolic parameter defined as the ratio of brachial pre-ejection period to brachial ejection time predicts cardiovascular events in patients with chronic kidney disease
    Szu Chia Chen
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Circ J 74:2206-10. 2010
    ..Brachial PEP (bPEP) and brachial ET (bET) can be automatically determined from an ankle-brachial index (ABI)-form device. The aim of this study is to investigate whether bPEP/bET is a useful predictor for CV events in patients with CKD...
  55. pmc Iron overload in polytransfused patients without heart failure is associated with subclinical alterations of systolic left ventricular function using cardiovascular magnetic resonance tagging
    Stéphanie Seldrum
    Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    J Cardiovasc Magn Reson 13:23. 2011
    ..Therefore we performed a comprehensive evaluation of systolic and diastolic cardiac function in such patients using tagged and phase-contrast CMR...
  56. ncbi Normative reference values for the tissue Doppler imaging parameters of left ventricular function: a population-based study
    Navtej S Chahal
    Department of Cardiovascular Medicine, Northwick Park Hospital, Harrow HA1 3UJ, UK
    Eur J Echocardiogr 11:51-6. 2010
    ..Tissue Doppler imaging (TDI) is used routinely to quantify left ventricular function and filling pressure. However, there remains a lack of percentile-based normative reference values for these clinically important parameters...
  57. ncbi Determination of right ventricular end systole by cardiovascular magnetic resonance imaging: a standard method of selection
    Rachael Edwards
    The Cardiovascular Research and Training Center, University of Washington, Seattle, WA, 98195 6422, USA
    Int J Cardiovasc Imaging 25:791-6. 2009
    ..of right ventricular (RV) volume and function, it may be important to use a consistent method to identify end systole (ES)...
  58. ncbi Nonlinear relations of blood pressure to cognitive function: the Baltimore Longitudinal Study of Aging
    Shari R Waldstein
    Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Cir, Baltimore, MD 21250, USA
    Hypertension 45:374-9. 2005
    ..Careful monitoring and treatment of both high and low BP levels may be critical to the preservation of cognitive function...
  59. ncbi Myocardial bridging is associated with alteration in coronary vasoreactivity
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street S W, Rochester, MN 55905, USA
    Eur Heart J 25:2134-42. 2004
    ..Myocardial bridging is a congenital condition associated with alteration in shear stress, however, its impact upon vasoreactivity remains undetermined...
  60. pmc Preliminary clinical study of left ventricular myocardial strain in patients with non-ischemic dilated cardiomyopathy by three-dimensional speckle tracking imaging
    Fengxia Duan
    Department of Medical Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Cardiovasc Ultrasound 10:8. 2012
    ..This study evaluated the feasibility of three-dimensional speckle tracking imaging (3D-STE) for assessment of the left ventricular myocardial strain in patients with non-ischemic dilated cardiomyopathy (DCM)...
  61. pmc Impact of left ventricular volume/mass ratio on diastolic function
    Adisai Buakhamsri
    Division of Cardiovascular Medicine, Department of Cardiology, Desk F 15, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 30:1213-21. 2009
    ..To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls...
  62. ncbi Left ventricular function in patients with uncomplicated well-controlled diabetes mellitus
    Laura Poanta
    University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, 2nd Department of Internal Medicine, Nicolae Pascaly 9 16, 400431 Cluj Napoca, Romania
    Med Ultrason 12:184-7. 2010
    ..Diastolic dysfunction may be the first stage of diabetic cardiomyopathy...
  63. ncbi Left ventricular strain and strain rate in a general population
    Tatiana Kuznetsova
    The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, University of Leuven, Campus Gasthuisberg, Herestraat 49, Box 702, B 3000 Leuven, Belgium
    Eur Heart J 29:2014-23. 2008
    ..We therefore described peak-systolic strain and SR of the LV in the general population and derived diagnostic thresholds for these measurements in a healthy subgroup...
  64. ncbi Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging
    Jing Ping Sun
    Department of Cardiovascular Imaging, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44196, USA
    J Am Soc Echocardiogr 17:132-8. 2004
    ..Like pulsed Doppler mitral inflow velocity, tissue velocity and strain rate show age-related changes...
  65. ncbi Left ventricular systolic and diastolic function in asymptomatic patients with moderate aortic stenosis
    Kjetil Steine
    Aker University Hospital, Oslo, Norway
    Am J Cardiol 102:897-901. 2008
    ..Augmented LV filling pressure measured by E/E'sep and impaired LV relaxation measured by reduced E'sep also indicate diastolic dysfunction in these patients...
  66. pmc Myocardial viability mapping by magnetic resonance-based multiparametric systolic strain analysis
    Brian P Cupps
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Thorac Surg 86:1546-53. 2008
    ..Regional myocardial contractility can be characterized by three-dimensional left ventricular (LV) multiparametric strain maps generated from sequential magnetic resonance imaging of radiofrequency tissue-tagging grid point displacements...
  67. pmc Torsion of the left ventricle during pacing with MRI tagging
    Jonathan M Sorger
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cardiovasc Magn Reson 5:521-30. 2003
    ..From these experiments we have shown that measuring torsion is an extremely sensitive indicator of the existence of ectopic excitation...
  68. ncbi Longitudinal myocardial velocity gradient derived from pulsed Doppler tissue imaging in AL amyloidosis: a sensitive indicator of systolic and diastolic dysfunction
    Jun Koyama
    Boston University Amyloidosis Treatment and Research Program, Boston, Massachusetts, USA
    J Am Soc Echocardiogr 17:36-44. 2004
    ..This study was performed to clarify whether the longitudinal myocardial velocity gradient could give new insights into the features of congestive heart failure in patients with primary amyloidosis...
  69. ncbi Binge drinking and ambulatory blood pressure
    K Seppa
    Department of Psychiatry, Tampere University Hospital, The University of Tampere, Medical School
    Hypertension 33:79-82. 1999
    ..These major and rapid changes in BP values might increase the likelihood of strokes, which are seen in increased numbers among young adults, especially during weekends and holidays...
  70. ncbi Speckle tracking echocardiography in the assessment of mouse models of cardiac dysfunction
    Yu Peng
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 297:H811-20. 2009
    ..45 and r = -0.44, respectively, and P = 0.006 for both). STE correctly identifies LV dysfunction and histological changes in mice and can be used for the serial assessment of cardiac remodeling in murine models...
  71. ncbi Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine PEM, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 37:2642-7. 2009
    ..Dynamic changes in systolic pressure, pulse pressure, and stroke volume in patients undergoing mechanical ventilation have emerged as useful techniques to assess volume responsiveness...
  72. ncbi Association of blood pressure status with the optic disk structure in non-glaucoma subjects: the Thessaloniki eye study
    Fotis Topouzis
    II Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Am J Ophthalmol 142:60-67. 2006
    ..To study the association of blood pressure (BP) status on the optic disk structure as measured with the Heidelberg Retina Tomograph (HRT) in people without glaucoma...
  73. ncbi Determinants of blood pressure response to quinapril in black and white hypertensive patients: the Quinapril Titration Interval Management Evaluation trial
    Evan Mokwe
    Department of Internal Medicine, Wayne State University, Detroit, Mich 48201, USA
    Hypertension 43:1202-7. 2004
    ....
  74. ncbi Characteristics of patients with uncontrolled hypertension in the United States
    D J Hyman
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    N Engl J Med 345:479-86. 2001
    ..Treatment of hypertension is one of the most common clinical responsibilities of U.S. physicians, yet only one fourth of patients with hypertension have their blood pressure adequately controlled...
  75. ncbi Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility
    Neil L Greenberg
    Cardiovascular Imaging Center, Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio OH 44195, USA
    Circulation 105:99-105. 2002
    ....
  76. ncbi Comparison of auscultatory and oscillometric blood pressures
    M K Park
    Department of Pediatrics, MSC 7734, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Arch Pediatr Adolesc Med 155:50-3. 2001
    ..To study the differences in blood pressure readings between the auscultatory and oscillometric (Dinamap model 8100; Critikon, Tampa, Fla) methods...
  77. ncbi Sex disparities in control and treatment of modifiable cardiovascular disease risk factors among patients with diabetes: Translating Research Into Action for Diabetes (TRIAD) Study
    Assiamira Ferrara
    Division of Research, Kaiser Permanente Medical Care Program of Northern California, 2000 Broadway, Oakland, CA 94612, USA
    Diabetes Care 31:69-74. 2008
    ..Cardiovascular disease (CVD) mortality has decreased in men but not in women with diabetes. We investigated whether sex differences in control and treatment of CVD risk factors might underlie this disparity...
  78. ncbi Quantitative assessment of ventricular function in children with single ventricles using the Doppler myocardial performance index
    R V Williams
    Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    Am J Cardiol 86:1106-10. 2000
    ..The MPI provides an objective method of assessing and following ventricular function in patients with single ventricles that is independent of ventricular geometry...
  79. ncbi Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population
    Edward Pringle
    Royal Sussex County Hospital, Brighton, UK
    J Hypertens 21:2251-7. 2003
    ..To investigate whether baseline systolic blood pressure variability was a risk factor for stroke, cardiovascular mortality or cardiac events during the Syst-Eur trial...
  80. pmc Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size
    Zoran B Popovic
    Department of Cardiology, Desk F 15, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Physiol 568:255-65. 2005
    ..019 (P<0.0001 versus 0). We conclude that MA velocity, displacement, and long-to-short axis displacement ratio scale allometrically to heart size. This reduces the relative long-axis contribution to heart function in small mammals...
  81. pmc Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study
    B E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53726 2336, USA
    Br J Ophthalmol 89:284-7. 2005
    ..To investigate the relation between change in systemic blood pressures and change in intraocular pressure...
  82. pmc Cardiac dyssynchrony analysis using circumferential versus longitudinal strain: implications for assessing cardiac resynchronization
    Robert H Helm
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circulation 111:2760-7. 2005
    ..It is unknown whether this analysis yields qualitative and/or quantitative results similar to those based on motion in the predominant muscle-fiber orientation (circumferential; epsiloncc)...
  83. pmc Insufficient control of blood pressure and incident diabetes
    Raffaele Izzo
    Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, Federico II University Naples, Naples, Italy
    Diabetes Care 32:845-50. 2009
    ..There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients...
  84. ncbi Optimal systolic and diastolic reconstruction windows for coronary CT angiography using dual-source CT
    Harald Seifarth
    Department of Clinical Radiology, University of Muenster, Albert Schweitzer Strasse 33, 8149 Muenster, Germany
    AJR Am J Roentgenol 189:1317-23. 2007
    ..The purpose of this study was to determine the position of the optimal systolic and diastolic reconstruction intervals for coronary CT angiography using dual-source CT...
  85. ncbi Age-associated changes in blood pressure in a longitudinal study of healthy men and women
    J D Pearson
    Gerontology Research Center, National Institute on Aging, Baltimore, USA
    J Gerontol A Biol Sci Med Sci 52:M177-83. 1997
    ..We examined longitudinal patterns of change in blood pressure in healthy male and female volunteers from the Baltimore Longitudinal Study of Aging (BLSA)...
  86. ncbi Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 116:1555-62. 2007
    ..We tested the hypothesis that sildenafil, an effective therapy for pulmonary arterial hypertension, would lower pulmonary vascular resistance and improve exercise capacity in patients with HF complicated by PH...
  87. ncbi Multi-detector row CT of left ventricular function with dedicated analysis software versus MR imaging: initial experience
    Kai Uwe Juergens
    Department of Clinical Radiology, University of Muenster, Albert Schweitzer Strasse 33, D 48149 Muenster, Germany
    Radiology 230:403-10. 2004
    ....
  88. ncbi Reproducibility of myocardial velocity and deformation imaging in term and preterm infants
    Suchita Joshi
    Department of Child Health, Cardiff University, Cardiff, UK
    Eur J Echocardiogr 11:44-50. 2010
    ..To establish whether it could also be used in infants, we investigated the reproducibility of myocardial velocities and deformation indices in term and preterm neonates...
  89. ncbi The influence of left ventricular size and global function on regional myocardial contraction and relaxation in an adult population free of cardiovascular disease: a tagged CMR study of the MESA cohort
    Verônica Rolim S Fernandes
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Cardiovasc Magn Reson 9:921-30. 2007
    ..These results are crucial to the interpretation of strain alterations induced by left ventricular remodeling in early heart failure...
  90. pmc Blood pressure components and the risk for end-stage renal disease and death in chronic kidney disease
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 4:830-7. 2009
    ..I examined the unique contributions of systolic (SBP) and diastolic BP (DBP) on the risk for ESRD and death in patients with chronic kidney disease (CKD)...
  91. ncbi Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study
    Toshio Ogihara
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Hypertension 56:196-202. 2010
    ....
  92. pmc Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 124:24-30. 2011
    ..We hypothesized that subclinical cardiac and noncardiac organ dysfunction would accelerate the manifestation of HF...
  93. ncbi Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: insights from echocardiography and exercise cardiac performance evaluation
    Vittorio Palmieri
    Division of Cardiology, Ospedale dei Pellegrini, ASL Napoli 1, Naples, Italy
    Diabetes Res Clin Pract 79:262-8. 2008
    ..Whether LV abnormalities identified at rest by echocardiography predict peak exercise LV performance in uncomplicated type 1 diabetes mellitus (DM1) is largely unknown...
  94. ncbi Alterations in left ventricular untwisting with ageing
    Bas M van Dalen
    Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, The Netherlands
    Circ J 74:101-8. 2010
    ..In order to gain further insight into age-associated changes of left ventricular (LV) diastolic function, the purpose of the current study was to investigate alterations in LV untwisting with ageing...
  95. ncbi Left ventricular systolic and diastolic dyssynchrony in asymptomatic hypertensive patients
    Sung A Chang
    Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea
    J Am Soc Echocardiogr 22:337-42. 2009
    ..The aims of this study were (1) to evaluate the prevalence of systolic and diastolic dyssynchrony and (2) to identify the main determinants of left ventricular (LV) dyssynchrony in asymptomatic patients with hypertension...
  96. ncbi Early detection of right ventricular systolic dysfunction by using myocardial acceleration during isovolumic contraction in patients with mitral stenosis
    Yelda Tayyareci
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Capa, Istanbul, Turkey
    Eur J Echocardiogr 9:516-21. 2008
    ....
  97. ncbi NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)alpha-mediated cardiovascular effects
    Mohammad Newaz
    Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
    Mutat Res 579:163-71. 2005
    ..Thus, apart from inhibition of ET-1 production, PPARalpha activation exerts protective actions in hypertension via a mechanism that involves NO production and/or inhibition of NAD(P)H oxidase activity...
  98. ncbi Myocardial tissue phase mapping with cine phase-contrast mr imaging: regional wall motion analysis in healthy volunteers
    Steffen E Petersen
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, England
    Radiology 238:816-26. 2006
    ....
  99. ncbi Diastolic and systolic asynchrony in patients with diastolic heart failure: a common but ignored condition
    Cheuk Man Yu
    Li Ka Shing Institute of Health Sciences, S H Ho Cardiovascular and Stroke Centre, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, People s Republic of China
    J Am Coll Cardiol 49:97-105. 2007
    ..The present study aimed to examine whether diastolic and systolic asynchrony exist in diastolic heart failure (DHF) and their prevalence and relationship to systolic heart failure (SHF) patients...
  100. ncbi Cardiac function index provided by transpulmonary thermodilution behaves as an indicator of left ventricular systolic function
    Julien Jabot
    AP HP, Hopital de Bicetre, Service de Reanimation Medicale, Paris Sud, Le Kremlin Bicetre, France
    Crit Care Med 37:2913-8. 2009
    ..The transpulmonary thermodilution calculates the cardiac function index, which is the ratio of cardiac output over global end-diastolic volume...
  101. ncbi Systolic time ratio by impedance cardiography to distinguish preserved vs impaired left ventricular systolic function in heart failure
    Brenda Thompson
    Cardiovascular Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9200, USA
    Congest Heart Fail 14:261-5. 2008
    ..50 demonstrated 93% sensitivity and 85% specificity. STR was able to distinguish intact (>50%) from impaired EF (< or =50%). STR by ICG has the potential to be a reliable method to monitor ventricular function in chronic HF...

Research Grants63

  1. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..vessels, and in particular the aorta, modulates hemodynamics by accommodating a portion of stroke volume during systole, reducing systolic pressure and maintaining systemic perfusion during diastole...
  2. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..Balloon inflation/deflation will coincide with the body's own physiological properties (i.e., systole/diastole), therefore matching closely the underlying Windkessel mechanism...
  3. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..Synchronizing assist with the heart will reduce the work required by the heart during systole and unload the left ventricle during diastole...
  4. Myosin ELC, a novel therapeutic target for FHC
    Danuta Szczesna-Cordary; Fiscal Year: 2013
    ..and SCD, and the C-terminal E143K mutation, which presented with mid-cavity hypertrophy, obstruction in systole and restrictive physiology...
  5. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia G Kranias; Fiscal Year: 2013
    ..SERCA2a and its reversible regulator phospholamban (PLN);Ca is stored by calsequestrin;and Ca is released during systole through the ryanodine receptor and its anchoring proteins junctin and triadin...
  6. Cardiomyocyte stretch and intracellular calcium release with advancing age
    TIMOTHY LEE DOMEIER; Fiscal Year: 2013
    ..the cardiac diastole, during which time the heart fills with blood and prepares for the next contraction during systole. With aging, diastolic dysfunction is characterized by increased "stiffness"...
  7. Novel calcium buffer for the treatment of diastolic heart failure
    Michelle L Asp; Fiscal Year: 2013
    ..Ca2+ must bind to contractile myofilament proteins in the myocyte to enable contraction in systole, and Ca2+ removal is required for relaxation in diastole...
  8. Titin-based adaptations of cardiac function
    Henk L Granzier; Fiscal Year: 2013
    ..Titin isoform switching is also likely to affect systole as titin- based passive tenson has been proposed to play an important role in the Frank-Starling mechanism (FSM) ..
  9. Stretch-Dependent Calcium Signaling in Heart
    WILLIAM JONATHAN LEDERER; Fiscal Year: 2013
    ..Ca2+ sparks in heart have been shown by the PI to occur under physiological conditions during diastole and systole. They not only underlie the normal [Ca2+]i transient but have been found to be critically important in mediating ..
  10. Clinical Utility of MR based Hydrodynamic Parameters in Chiari Malformation
    Francis Loth; Fiscal Year: 2010
    ..were found to have less volumetric expansion (26114%) compared to three healthy volunteers (6214%) during systole [6]...
  11. Structural Basis of Ventricular Function
    Xin Yu; Fiscal Year: 2010
    ..basis of myocardial wall thickening by directly assessing myocardial structural changes from diastole to systole. Further, we have also established in vivo MR tagging methods to assess regional myocardial wall motion in small ..
  12. Portable pneumatic driver for counterpulsation therapy
    Paul A Spence; Fiscal Year: 2010
    ..The CPD fills during native heart systole lowering ventricular workload, and ejects during diastole augmenting myocardial and end-organ perfusion...
  13. Defining 4D Ventricular Mechanics in Acquired and Congenital Heart Disease
    Xubo Song; Fiscal Year: 2013
    ..deformation without angle dependency, including circumferential shortening strain, radial thickening strain in systole and twisting and untwisting...
  14. Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic Function
    Himanshu Gupta; Fiscal Year: 2013
    ..Contraction of myocardial bundles and their interaction with extracellular matrix during systole results in storage of torsional potential energy...
  15. Counterpulsation Device with Integrated ECG Sensing
    Robert D Dowling; Fiscal Year: 2010
    ..The CPD fills with blood during native heart systole lowering ventricular workload, and ejects during diastole augmenting myocardial and end-organ perfusion...
  16. Counterpulsation Device with Integrated EKG System for Chronic Partial Circulator
    Paul A Spence; Fiscal Year: 2013
    ..Symphony is timed with the EKG to fill during systole and eject during diastole...
  17. Development of an Image Driven Mechanical Model of the Left Ventricle
    ALEXANDER ISTVAN VERESS; Fiscal Year: 2010
    ..that EF, wall motion, and wall thickening measures, are indirect measures of left ventricular tissue contraction (systole) and dilation (diastole)...
  18. Quantitative cardiac MRI perfusion for longitudinal studies
    EDWARD VR DI BELLA; Fiscal Year: 2013
    ..and repeatability of the proposed quantitative methods and the differences in perfusion and MPR measured at systole and diastole, including determining if systole or diastole is most repeatable when quantifying perfusion...
  19. Measuring the Efficacy of Endovascular Treatment of AAA
    Peter Faries; Fiscal Year: 2007
    ..the aneurysm sac will be correlated with the change in the cross-sectional area and volume of the aneurysm during systole and diastole using cine magnetic resonance imaging...
  20. REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Julius Guccione; Fiscal Year: 1999
    ..associated with stretching of muscle fibers in the adjacent noninfarcted (border zone) region during isovolumic systole. The mechanism of this regional dysfunction is poorly understood, but it likely involves reduced myocardial ..
  21. FUNCTIONAL CHARACTERISTICS OF THE LEFT HEART
    HAROLD DODGE; Fiscal Year: 1990
    ..after thrombolytic therapy in myocardial infarction, (3) regional abnormalities of timing of motion during systole and diastole, the relationship of these abnormalities to global ventricular performance and to conduction defects ..
  22. FROM CARDIAC MUSCLE TO VENTRICLE
    William Hunter; Fiscal Year: 1999
    ..sarcomeres are coupled with the cytoskeletal-extracellular matrix to determine 3D myocardial mechanics during systole. In the beating heart, sarcomeres are exposed to forces not only parallel but also perpendicular to their ..
  23. Development of a Counterpulsation Therapy Device
    Paul Spence; Fiscal Year: 2009
    ..The CPD fills during native heart systole lowering ventricular workload, and ejects during diastole augmenting myocardial and end-organ perfusion...
  24. DETERMINANTS OF PULMONARY ARTERY BLOOD VELOCITY PROFILE
    Carol Lucas; Fiscal Year: 1991
    ..are increased flow reversal in the main pulmonary artery and decreased acceleration time (time from onset of systole to peak velocity)...
  25. MECHANISM OF VENTRICULAR OUTFLOW OBSTRUCTION IN IHSS
    Robert Levine; Fiscal Year: 1991
    ..it can occur when the papillary muscles (PMs) are tethering the mitral valve posteriorly and at a time early in systole when Venturi forces are likely to be weak...
  26. MECHANICAL FACTORS AND ENERGY LOSS IN MYOCARDIAL REGIONS
    Joseph Kedem; Fiscal Year: 2001
    ..and global LV work will be calculated on-line by integration of the length-force and flow-pressure loops during systole. Local and global coronary blood flow will be measured, and regional O2 saturations as well as coronary sinus ..
  27. 3-D ANALYSIS OF LEFT VENTRIULAR REGIONAL WALL MOTION
    R Clark; Fiscal Year: 1990
    ..package will be obtained from magnetic resonance images (MRI) of patients' hearts taken at end-diastole and end-systole. Image data will be transferred to inexpensive, but powerful, computer graphics workstations for analysis...
  28. Development and Evaluation of MRI Methods to Assess Diastolic Function
    Leon Axel; Fiscal Year: 2012
    ..applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated contraction phase of the cardiac cycle...
  29. CARDIAC VOLUME BY BIPLANE ECHOCARDIOGRAPHY
    Nelson Schiller; Fiscal Year: 1980
    ..early systolic contraction abnormalities in reversible ischemia by determining ejection fraction in the first third of systole. D) Detecting subgroups of diabetic heart disease by correlating cardiac volume with diabetic classification.
  30. MECHANISMS OF CRUSTACEAN CARDIAC SUSPENSORY LIGAMENTS
    MALCOLM DEMONT; Fiscal Year: 1993
    ..by releasing the strain energy that is stored in the connective tissue as the wall of the heart thickens during systole. This elastic mechanism may play a very important role in the cardiac cycle; evidence of this is provided by some ..
  31. Mechanoelectrical Transduction in the Myocardium
    Frederick Sachs; Fiscal Year: 2006
    ..It is well established in the whole heart that the distribution of mechanical strain during a systole plays a key role in the electromechanical function...
  32. VENTRICULAR SYSTOLIC INTERACTIONS DURING HEART FAILURE
    David Farrar; Fiscal Year: 1993
    ..ratios of changes in RV pressure and pulmonary flow to change in LP pressure as a function of time during systole, and the stroke work gain (Grvsw) will be calculated as the integrated change in RV stroke work divided by ..
  33. Flow of Effects on Endothelial-Monocyte Interactions
    GEORGE TRUSKEY; Fiscal Year: 2006
    ..in regions of flow reversal must still occur rapidly in order to resist higher shears tresses arising during systole. Recently we observed that adhesion of monocytic cells is enhanced by forces acting normal to the surface between ..
  34. CONTRACTILE FORCE AND CALCIUM HANDLING IN HEART FAILURE
    Pieter de Tombe; Fiscal Year: 2000
    ..force development during the development of CHF is caused by reduced intracellular calcium concentration during systole: Accurate and calibrated intracellular calcium will be measured directly in isolated cardiac trabeculae by ..
  35. LEFT VENTRICULAR TIME-VARYING ELASTANCE
    William Little; Fiscal Year: 1990
    ..canine hearts suggest that the LV behaves as an elastic structure that stiffens in a predictable manner during systole, thus, it can be described as a time-varying elastance...
  36. PREDICTION OF MYOCARDIAL RECOVERABILITY WITH 3D MRI
    Thoralf Sundt; Fiscal Year: 2002
    ..Three-dimensional contour maps can then be generated from MRI images obtained at early systole, end-systole, and several intervals in between...
  37. Calcium-independent enhancement of contractility in normal and failing cardiomyoc
    Michael Regnier; Fiscal Year: 2009
    ..Most current therapies focus on mechanisms that enhance intracellular Ca2+ during systole which, among other things, can affect diastolic function...
  38. MECHANICAL INTERACTION OF ISCHEMIC AND NONISCHEMIC AREAS
    WILBUR LEW; Fiscal Year: 1990
    ..portion of the shortening by nonischemic areas is expended in stretching the ischemic zone during isovolumic systole, thereby reducing the amount of nonischemic area shortening during the ejection phase...
  39. CARDIOMYOCYTE MECHANOTRANSDUCTION AND THE CARDIAC CYCLE
    Richard Lee; Fiscal Year: 2001
    ..Myocardial mechanical overload may be broadly categorized as "pressure" overload (mechanical overload in systole) or volume overload (mechanical overload in diastole)...
  40. ROBUST CONTRAST FOR AUTO--ANALYSIS OF CARDIAC MRI
    John Oshinski; Fiscal Year: 2000
    ..Comparisons would include endocardial areas and volumes in the left and right ventricles, ejection fractions, the peak rates of ejection and filling, and the times at which end systole, end diastole, and the peak flow rates occur.
  41. LEFT VENTRICULAR WALL MOTION ANALYSIS
    Paul Clayton; Fiscal Year: 1980
    ..This will be done by analyzing ventricular motion throughout systole and diastole in groups of patients with different pathological conditions (normal, ischemic, and fibrotic ..
  42. COMPREHENSIVE DIAGNOSIS OF ISCHEMIC HEART DISEASE BY MRI
    Phillip Yang; Fiscal Year: 2002
    ..Cardiac-gated single shot imaging will enable rapid acquisition of several frames per systole over multiple planes to cover the entire heart for first- pass perfusion imaging...
  43. COMPREHENSIVE DIAGNOSIS OF ISCHEMIC HEART DISEASE BY MRI
    Phillip Yang; Fiscal Year: 2004
    ..Cardiac-gated single shot imaging will enable rapid acquisition of several frames per systole over multiple planes to cover the entire heart for first- pass perfusion imaging...
  44. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2004
    ..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole.
  45. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  46. Expert Visual Guidance of Ultrasound for Telemedicine
    Florence Sheehan; Fiscal Year: 2006
    ..Specific Aim #4 is to make the guidance easily applicable to different organs. [unreadable] [unreadable]..
  47. Neurohormonal Blockade and Outcomes in Diastolic Heart Failure
    Ali Ahmed; Fiscal Year: 2010
    ..The proposed study will examine the effect of neurohormonal blockade in propensity matched OPTIMIZE-HF participants with diastolic heart failure. ..
  48. Heart failure, chronic kidney disease, and renin-angiotensin system inhibition
    Ali Ahmed; Fiscal Year: 2009
    ....
  49. Heart Failure and Beta-Blocker Use in Older Adults
    Ali Ahmed; Fiscal Year: 2006
    ..abstract_text> ..
  50. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Gregg Fonarow; Fiscal Year: 2006
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  51. STICH Trial-Echocardiographic Core Laboratory
    Jae Oh; Fiscal Year: 2007
    ..abstract_text> ..
  52. Oxidative Stress and Vascular Function in Chronic Kidney Disease
    David Edwards; Fiscal Year: 2008
    ..Understanding these mechanisms may aid in the evaluation of therapies aimed at improving vascular function in chronic kidney disease. [unreadable] [unreadable] [unreadable]..
  53. HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTS
    SHARI WALDSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  54. VASCULAR FUNCTION BY MAGNETIC RESONANCE ANGIOGRAPHY
    HARRY SILBER; Fiscal Year: 2005
    ..abstract_text> ..
  55. Atrial Fibrillation: Incidence, Risk Factors, and Genetics
    SUSAN HECKBERT; Fiscal Year: 2010
    ..The ultimate goal of this research is to increase knowledge about AF risk factors and prognosis and to enhance prevention efforts and improve care for patients with AF. ..
  56. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  57. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  58. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  59. A central aortic pulse wave velocity measurement device
    Gary Mitchell; Fiscal Year: 2005
    ..This innovative technology will enable accurate diagnosis and risk stratification in a primary care setting and will facilitate further research aimed at evaluating interventions that may reduce conduit vessel stiffness. ..
  60. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  61. The Pathophysiology of T-wave Alternans
    Sanjiv Narayan; Fiscal Year: 2005
    ..This structured approach will ensure the successful completion of this project and, in this way, the development of the applicant into an independent clinician-investigator. ..
  62. Controlled Reperfusion for Whole Body Ischemic Injury
    Gerald Buckberg; Fiscal Year: 2005
    ..If this novel method of management is correct, the scheme of diagnosis and management of this almost always fatal cardiac arrest complex will change markedly. ..