diastole

Summary

Summary: Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.

Top Publications

  1. ncbi Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    Margaret M Redfield
    Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 9, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    JAMA 289:194-202. 2003
  2. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
  3. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
  4. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
  5. ncbi Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
    Luuk J Rijzewijk
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 52:1793-9. 2008
  6. ncbi Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
  7. ncbi Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness
    Phillip E Gates
    Human Cardiovascular Research Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Eur Heart J 24:2213-20. 2003
  8. ncbi Heart failure with normal left ventricular ejection fraction
    Micha T Maeder
    Heart Failure Research Group, Baker IDI Heart and Diabetes Institute, and Heart Center, Alfred Hospital, St Kilda Road, Central Melbourne 8008 VIC, Australia
    J Am Coll Cardiol 53:905-18. 2009
  9. ncbi Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
  10. ncbi Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus
    John K Boyer
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Cardiol 93:870-5. 2004

Detail Information

Publications295 found, 100 shown here

  1. ncbi Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    Margaret M Redfield
    Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 9, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    JAMA 289:194-202. 2003
    ..Yet, the prevalence of diastolic dysfunction and its relation to systolic dysfunction and CHF in the community remain undefined...
  2. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
    ..The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF...
  3. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
    ..This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes...
  4. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
    ..In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden...
  5. ncbi Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
    Luuk J Rijzewijk
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 52:1793-9. 2008
    ....
  6. ncbi Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
    ..Further, diastolic function is seldom systematically assessed based on standardized techniques...
  7. ncbi Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness
    Phillip E Gates
    Human Cardiovascular Research Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Eur Heart J 24:2213-20. 2003
    ..We sought to determine if attenuation of the age-associated increase in arterial stiffness by habitual aerobic-endurance exercise would have corresponding effects on left ventricular (LV) structure and diastolic function...
  8. ncbi Heart failure with normal left ventricular ejection fraction
    Micha T Maeder
    Heart Failure Research Group, Baker IDI Heart and Diabetes Institute, and Heart Center, Alfred Hospital, St Kilda Road, Central Melbourne 8008 VIC, Australia
    J Am Coll Cardiol 53:905-18. 2009
    ..We evaluate the utility of commonly applied echocardiographic measures and biomarkers and integrate mechanistic observations into potential future therapeutic directions...
  9. ncbi Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
    ..It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven...
  10. ncbi Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus
    John K Boyer
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Cardiol 93:870-5. 2004
    ..TDI markedly improved the echocardiographic detection of diastolic dysfunction in asymptomatic patients with type 2 diabetes...
  11. ncbi Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance
    Alicia M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 27:2879-88. 2006
    ..We used these techniques to establish the reference values for right ventricular (RV) volumes and function...
  12. ncbi Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 117:43-51. 2008
    ..The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF...
  13. pmc Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations
    Fan Bai
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA
    Biophys J 100:1014-23. 2011
    ..Decreased contractility (T(act)) in V95A and D175N may further contribute to the severity of myocyte hypertrophy and related prognosis of the disease...
  14. ncbi New Doppler echocardiographic applications for the study of diastolic function
    M J Garcia
    Cardiovascular Imaging Center, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 32:865-75. 1998
    ..This review will focus on the complementary role of color M-mode and tissue Doppler echocardiography and traditional Doppler indices of LV filling and PV flow in the assessment of diastolic function...
  15. ncbi Age- and gender-related ventricular-vascular stiffening: a community-based study
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Circulation 112:2254-62. 2005
    ..The prevalence of HFnlEF increases strikingly with age, particularly in women. We hypothesized that ventricular-vascular stiffening may occur with age and be more pronounced in women in the general community...
  16. ncbi Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart disease
    Mehdi H Shishehbor
    Department of Internal Medicine, Cardiovascular Imaging Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Cardiol 91:1514-7, A9. 2003
  17. ncbi What mechanisms underlie diastolic dysfunction in heart failure?
    David A Kass
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circ Res 94:1533-42. 2004
    ..This review puts these developments into perspective with the major aim of highlighting current knowledge gaps and controversies...
  18. ncbi Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance
    A M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 8:417-26. 2006
    ..These novel data have particular importance for clinical practice and clinical trials using CMR...
  19. ncbi Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase
    Jerald Curran
    Rush University Medical Center, Chicago, IL 60611, USA
    Circ Res 100:391-8. 2007
    ..The results suggest that beta-AR stimulation enhances diastolic SR Ca leak in a manner that is (1) CaMKII dependent, (2) not protein kinase A dependent, and 3) not dependent on bulk [Ca](i)...
  20. ncbi CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation
    Stefan Neef
    Department of Cardiology and Pneumology Heart Center, Georg August University Gottingen, Robert Koch Strasse 40, Gottingen, Germany
    Circ Res 106:1134-44. 2010
    ..In ventricular myocardium, ryanodine receptor type 2 (RyR2) phosphorylation by Ca(2+)/calmodulin-dependent protein kinase (CaMK)II is emerging as an important mechanism for SR Ca(2+) leak...
  21. pmc Diastolic dysfunction and diastolic heart failure: diagnostic, prognostic and therapeutic aspects
    Maurizio Galderisi
    Division of Cardioangiology, CCU Department of Clinical and Experimental Medicine, Federico II University, Medical School Napoli, Italy
    Cardiovasc Ultrasound 3:9. 2005
    ..Several trials, completed or ongoing, have been planned to treat DD and diastolic HF...
  22. ncbi Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure
    Minoru Yambe
    Second Department of Internal Medicine, Tokyo Medical University, Japan
    Hypertens Res 27:625-31. 2004
    ..Therefore, increased arterial stiffness is a possible simultaneous risk for atherosclerotic cardiovascular disease and diastolic heart failure in patients with hypertension...
  23. ncbi Atrial electrical and structural changes associated with longstanding hypertension in humans: implications for the substrate for atrial fibrillation
    Caroline Medi
    Department of Cardiology, Alfred Hospital and Baker IDI, Melbourne, Australia
    J Cardiovasc Electrophysiol 22:1317-24. 2011
    ....
  24. pmc Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure
    N Wisniacki
    Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK
    Heart 91:32-7. 2005
    ..To evaluate insulin resistance and systemic inflammation in older patients with systolic (SHF) or diastolic heart failure (DHF)...
  25. ncbi Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction
    Joao L Cavalcante
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 110:1793-8. 2012
    ..In conclusion, EFV is an independent predictor of impaired diastolic function in apparently healthy overweight patients even after accounting for associated co-morbidities such as metabolic syndrome, hypertension, and subclinical CAD...
  26. ncbi Assessment of left ventricular diastolic function: the power, possibilities, and pitfalls of echocardiographic imaging techniques
    Kofo O Ogunyankin
    Department of Medicine and Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA
    Can J Cardiol 27:311-8. 2011
    ..A better understanding of the physiology of diastole highlights the relevance of the cardiac substrate in the genesis of diastolic dysfunction...
  27. ncbi Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure
    Philip M Mottram
    University of Queensland, Brisbane, Australia
    Circulation 110:558-65. 2004
    ....
  28. ncbi Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function
    Sabine J Van Dijk
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circ Heart Fail 5:36-46. 2012
    ..We studied if changes in sarcomeric properties in HCM depend on the underlying protein mutation...
  29. ncbi Ventricular untwisting: a temporal link between left ventricular relaxation and suction
    Yuichi Notomi
    Department of Cardiovascular Medicine F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 294:H505-13. 2008
    ..To understand the interaction between LV mechanics and inflow during early diastole, Doppler tissue images (DTI), catheter-derived pressures (apical and basal LV, left atrial, and aortic), and LV ..
  30. ncbi Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function
    Sebastiaan Hammer
    Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 52:1006-12. 2008
    ..This study sought to assess the effects of prolonged caloric restriction in obese patients with type 2 diabetes mellitus (T2DM) on myocardial triglyceride (TG) content and myocardial function...
  31. ncbi Unlocking the mysteries of diastolic function: deciphering the Rosetta Stone 10 years later
    Steven J Lester
    Division of Cardiovascular Disease, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Am Coll Cardiol 51:679-89. 2008
    ..The purpose of this review is to highlight the developments in echo-Doppler and refinements in our knowledge that have occurred over the past decade that enhance our understanding of diastology...
  32. pmc Blood pressure components and the risk for end-stage renal disease and death in chronic kidney disease
    Rajiv Agarwal
    Department of Medicine, Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 4:830-7. 2009
    ..I examined the unique contributions of systolic (SBP) and diastolic BP (DBP) on the risk for ESRD and death in patients with chronic kidney disease (CKD)...
  33. ncbi Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function
    Vicky Y Wang
    Auckland Bioengineering Institute, University of Auckland, Level 6, UniServices House, 70 Symonds Street, Auckland 1142, New Zealand
    Med Image Anal 13:773-84. 2009
    ..synchronized to the tagging data, were used as the loading constraints to simulate the LV deformation during diastole. Simulation of diastolic LV mechanics allowed us to estimate the stiffness of the passive LV myocardium based on ..
  34. pmc Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity
    Joshua D Lovelock
    Section of Cardiology, University of Illinois at Chicago, 60612, USA
    Circ Res 110:841-50. 2012
    ..Oxidative stress has been shown to increase late inward sodium current (I(Na)), reducing the net cytosolic Ca(2+) efflux...
  35. ncbi Aortic stiffness for the detection of preclinical left ventricular diastolic dysfunction: pulse wave velocity versus pulse pressure
    Walter P Abhayaratna
    Academic Unit of Internal Medicine, The Canberra Hospital, Canberra, Australia
    J Hypertens 26:758-64. 2008
    ..Our aim was to compare the performances of wave reflection-dependent (pulse pressure) and independent [carotid-femoral pulse wave velocity (PWV)] indexes of aortic stiffness to detect preclinical LV diastolic dysfunction...
  36. ncbi Alterations of left ventricular myocardial characteristics associated with obesity
    Chiew Y Wong
    University of Queensland, Brisbane, Australia
    Circulation 110:3081-7. 2004
    ..We sought whether body mass index (BMI) and insulin levels were associated with subclinical myocardial disturbances...
  37. pmc Left ventricular torsion, energetics, and diastolic function in normal human aging
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Physiol Heart Circ Physiol 302:H885-92. 2012
    ..age were the early filling percentage (EFP, the left ventricular volume increase from end systole to mid-diastole divided by stroke volume × 100), which decreased with age, indicating impaired early diastolic filling (r = -0...
  38. pmc Combined exercise training in asymptomatic elderly with controlled hypertension: effects on functional capacity and cardiac diastolic function
    Gabriel N Guirado
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University, UNESP, SP, Brazil
    Med Sci Monit 18:CR461-5. 2012
    ..This was a prospective study evaluating the effects of a 6-month combined exercise training period on functional capacity and diastolic function in sedentary elderly patients with controlled arterial hypertension...
  39. ncbi Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?
    Franz H Messerli
    Division of Cardiology, St Luke s Roosevelt Hospital, New York, New York 10019, USA
    Ann Intern Med 144:884-93. 2006
    Because coronary perfusion occurs mainly during diastole, patients with coronary artery disease (CAD) could be at increased risk for coronary events if diastolic pressure falls below critical levels.
  40. ncbi New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina, The Gazes Cardiac Research Institute and the Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circulation 105:1503-8. 2002
  41. ncbi Proteolytic N-terminal truncation of cardiac troponin I enhances ventricular diastolic function
    John C Barbato
    Section of Molecular Cardiology, Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
    J Biol Chem 280:6602-9. 2005
    ....
  42. ncbi Prevalence of left ventricular diastolic dysfunction in a general population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Circ Heart Fail 2:105-12. 2009
    ....
  43. pmc Extensible behavior of titin in the miniswine left ventricle
    Martin M LeWinter
    Cardiology Unit, Fletcher Allen Health Care, 111 Colchester Ave, Burlington, VT 05401, USA
    Circulation 121:768-74. 2010
    ..We hypothesized that extension of titin in relation to SL differs in large mammals and that this difference is functionally important...
  44. ncbi Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet
    Y Huang
    Department of Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Circulation 109:97-102. 2004
    ..Although hypercholesterolemia is a well-established risk factor for coronary artery disease, little is known regarding its direct effects on cardiac function...
  45. ncbi Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes
    Lutz Pohlmann
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Circ Res 101:928-38. 2007
    ..ATPase inhibitors 2,3-butanedione monoxime or blebbistatin, indicating residual actin-myosin interaction in diastole. The relationship between cytosolic Ca2+ and SL showed that KO cells started to contract at lower Ca2+ without ..
  46. ncbi Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure
    Yung Hsin Yeh
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Circ Arrhythm Electrophysiol 1:93-102. 2008
    ..Focal sources of unknown mechanism have been described in CHF-related atrial fibrillation. The authors hypothesized that abnormal calcium (Ca(2+)) handling contributes to the CHF-related atrial arrhythmogenic substrate...
  47. ncbi Cardiac lipid accumulation associated with diastolic dysfunction in obese mice
    Christina Christoffersen
    Departments of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark 2100
    Endocrinology 144:3483-90. 2003
    ..The results also suggest that the cardiac lipid accumulation is paralleled by cardiac diastolic dysfunction in ob/ob mice...
  48. ncbi Tissue Doppler echocardiography in persons with hypertension, diabetes, or ischaemic heart disease: the Copenhagen City Heart Study
    Rasmus Mogelvang
    Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    Eur Heart J 30:731-9. 2009
    ..To test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) in the general population...
  49. pmc Progression of left ventricular diastolic dysfunction and risk of heart failure
    Garvan C Kane
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA 306:856-63. 2011
    ..Although diastolic dysfunction plays a role in heart failure with preserved ejection fraction, little is known about age-dependent longitudinal changes in diastolic function in community populations...
  50. ncbi A clinician's guide to tissue Doppler imaging
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e396-8. 2006
  51. ncbi Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium
    G Hasenfuss
    Zentrum Innere Medizin, Abteilung Kardiologie und Pneumologie, Universitat Gottingen, Germany
    Circulation 99:641-8. 1999
    ..In the failing human heart, sarcoplasmic reticulum (SR) calcium handling is impaired, and therefore, calcium elimination and diastolic function may depend on the expression of sarcolemmal Na+-Ca2+ exchanger...
  52. pmc Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes
    Veronique A Lacombe
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1787-97. 2007
    ..These data suggest that in vitro impairment of Ca(2+) reuptake during myocyte relaxation contributes to in vivo diastolic dysfunction, with preserved global systolic function, during diabetes...
  53. ncbi Flow mediated dilatation and cardiac function in type 1 diabetes mellitus
    Bharati Shivalkar
    Department of Cardiology, University Hospital Antwerp, Edegem, Belgium
    Am J Cardiol 97:77-82. 2006
    ..In conclusion, FMD is associated with abnormal segmental cardiac function in type 1 DM...
  54. ncbi Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair
    Judith Therrien
    Toronto Congenital Cardiac Centre for Adults, Toronto, Ontario, Canada
    Am J Cardiol 95:779-82. 2005
    ..12). In no patients with a RV end-diastolic volume >170 ml/m2 or a RV end-systolic volume >85 ml/m2 before pulmonary valve replacement were RV volumes "normalized" after surgery...
  55. ncbi Relation of arterial stiffness to left ventricular diastolic function and cardiovascular risk prediction in patients > or =65 years of age
    Walter P Abhayaratna
    Division of Cardiovascular Diseases and Internal Medicine, Rochester, Minnesota, USA
    Am J Cardiol 98:1387-92. 2006
    ..Aortic PP, brachial PP, and PWV appeared superior to AP in risk discrimination in this elderly cohort...
  56. ncbi Results of the pilot study for the Hypertension in the Very Elderly Trial
    Christopher J Bulpitt
    Faculty of Medicine, Imperial College London, UK
    J Hypertens 21:2409-17. 2003
    ..The risks and benefits of treating hypertension in individuals older than 80 years are uncertain. A meta-analysis has suggested that a reduction in stroke events of 36% may have to be balanced against a 14% increase in total mortality...
  57. ncbi Left ventricular diastolic filling and systolic function of young and older trained and untrained men
    James C Baldi
    Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand
    J Appl Physiol (1985) 95:2570-5. 2003
    ..05), but it was similar in trained and untrained young men. These findings suggest that early diastolic filling is not affected by training in older men, and the effect of training on A' and S' is different in young and older men...
  58. ncbi Noninvasive single-beat determination of left ventricular end-systolic elastance in humans
    C H Chen
    Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan
    J Am Coll Cardiol 38:2028-34. 2001
    ..SV), echo-derived ejection fraction (EF) and an estimated normalized ventricular elastance at arterial end-diastole (E(Nd)): E(es(sb)) = [P(d) - (E(Nd(est)) x P(s) x 0.9)[/(E(Nd(est)) x SV)...
  59. ncbi Diastolic stress echocardiography: a novel noninvasive diagnostic test for diastolic dysfunction using supine bicycle exercise Doppler echocardiography
    Jong Won Ha
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Echocardiogr 18:63-8. 2005
    ..Our preliminary results suggest the hemodynamic consequences of exercise-induced increase in diastolic filling pressure can be demonstrated noninvasively with exercise Doppler echocardiography...
  60. pmc Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
    Martin Magnusson
    Department of Cardiology, Malmo University Hospital, Lund University, Lund, Sweden
    Cardiovasc Diabetol 9:2. 2010
    ....
  61. ncbi Prognostic significance of left ventricular diastolic dysfunction in essential hypertension
    Giuseppe Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Perugia, Italy
    J Am Coll Cardiol 39:2005-11. 2002
    ..We sought to assess the prognostic value of alterations in left ventricular (LV) diastolic function in patients with essential hypertension...
  62. ncbi The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function
    Rutger W van der Meer
    Department of Radiology C2 S, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Heart J 29:1516-22. 2008
    ..Therefore, the purpose of our study was to evaluate the effects of ageing on myocardial TG content, and to determine the association between myocardial TG content and heart function...
  63. pmc Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study
    Wilfried Dinh
    Institute for Heart and Circulation Research, University Witten Herdecke, Germany
    Cardiovasc Diabetol 9:63. 2010
    ..We assessed whether IR and abnormalities of the glucose metabolism are related to LVDD...
  64. ncbi Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi-Ethnic Study of Atherosclerosis
    Verônica Rolim S Fernandes
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Arterioscler Thromb Vasc Biol 28:194-201. 2008
    ..Few studies have investigated the relationship between arterial compliance and LV function in humans, and none used cardiovascular MRI...
  65. ncbi Afterload induced changes in myocardial relaxation: a mechanism for diastolic dysfunction
    A F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Portugal
    Cardiovasc Res 43:344-53. 1999
    ..It is well known that high afterload slows myocardial relaxation. This contribution investigated to what extent afterload elevation could also affect LV filling pressures including end-diastolic LV pressure (LVP)...
  66. ncbi Metabolic syndrome is associated with abnormal left ventricular diastolic function independent of left ventricular mass
    Lisa De Las Fuentes
    Cardiovascular Imaging and Clinical Research Core Laboratory, Campus Box 8086, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Eur Heart J 28:553-9. 2007
    ..To characterize the extent to which metabolic syndrome criteria predict left ventricular (LV) structure and function...
  67. ncbi Prevalence of left ventricular diastolic dysfunction in the community. Results from a Doppler echocardiographic-based survey of a population sample
    M Fischer
    Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, Franz Josef Strauss Allee 11, Germany
    Eur Heart J 24:320-8. 2003
    ....
  68. ncbi Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations
    Miho Kawaguchi
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 107:714-20. 2003
    ..We hypothesized that such patients also display combined ventricular-systolic and arterial stiffening that can exacerbate blood pressure lability and diastolic dysfunction under stress...
  69. ncbi Left ventricular diastolic dysfunction in the early stage of chronic kidney disease
    Takenori Otsuka
    Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2 17 6 Ohashi, Meguro ku, Tokyo 153 8515, Japan
    J Cardiol 54:199-204. 2009
    ..The disadvantageous effect of kidney dysfunction on left ventricular (LV) diastolic function is still unknown...
  70. ncbi Left ventricular diastolic dysfunction in adolescents with type 1 diabetes reflects the long- but not short-term metabolic control
    Malgorzata Wojcik
    Department of Pediatric and Adolescent Endocrinology, Jagiellonian University, Krakow, Poland
    J Pediatr Endocrinol Metab 23:1055-64. 2010
    ..The aim of this study was to compare the LV morphology and function in adolescents with DM1 and their healthy peers...
  71. ncbi Imaging the right ventricle--current state of the art
    Luc L Mertens
    The Labatt Family Heart Center, Division of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Cardiol 7:551-63. 2010
    ....
  72. ncbi Left ventricular myocardial velocities and deformation indexes in top-level athletes
    Antonello D'Andrea
    Second University of Naples, Monaldi Hospital Naples, Naples, Italy
    J Am Soc Echocardiogr 23:1281-8. 2010
    ..The aim of this study was to define the range of left ventricular (LV) velocities and deformation indexes in highly trained athletes, analyzing potential differences induced by different long-term training protocols...
  73. pmc Systolic and diastolic ventricular function in zebrafish embryos: influence of norepenephrine, MS-222 and temperature
    Martin A Denvir
    Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, EH16 4TJ, UK
    BMC Biotechnol 8:21. 2008
    ..IonOptix Inc), the motion of a small region of the cardiac ventricle wall was converted to a continuous chart trace allowing analysis of wall motion amplitude (WMA) and myocardial wall velocity during systole (MWVs) and diastole (MWVd).
  74. ncbi Determinants of left ventricular untwisting behaviour in patients with dilated cardiomyopathy: analysis by two-dimensional speckle tracking
    M Saito
    Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Heart 95:290-6. 2009
    ..However, the pathophysiology of LV untwisting behavior has not been fully investigated. The aim of this study was to investigate the determinants of LV peak untwisting velocity in patients with dilated cardiomyopathy (DCM)...
  75. ncbi Magnetic resonance assessment of aortic pulse wave velocity, aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus
    Rutger W van der Meer
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Magn Reson 9:645-51. 2007
    ..Furthermore, CMR is a reliable method for assessing left ventricular (LV) function. The purpose of this study was to assess LV function, PWV, and aortic distensibility in patients with DM2 using MR...
  76. ncbi Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction
    Nan Jia
    Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, PR China
    Cardiovasc Ther 30:117-23. 2012
    ..We tested whether allopurinol could decrease myocardial oxidative stress and attenuate cardiac fibrosis and left ventricular diastolic dysfunction in angiotensin II (AngII)-induced hypertensive mice...
  77. ncbi The relationship among central obesity, systemic inflammation, and left ventricular diastolic dysfunction as determined by structural equation modeling
    Cho Kai Wu
    Department of Internal Medicine, National Taiwan University College of Medicine and Hospital Yun Lin Branch, Yun Lin, Taiwan
    Obesity (Silver Spring) 20:730-7. 2012
    ..373. P < 0.001)). Using structural equation modeling, we concluded that higher amounts of VAT were associated with low-grade inflammation and this may lead to subclinical LV diastolic dysfunction in otherwise-healthy subjects...
  78. ncbi Determinants of blood pressure response to quinapril in black and white hypertensive patients: the Quinapril Titration Interval Management Evaluation trial
    Evan Mokwe
    Department of Internal Medicine, Wayne State University, Detroit, Mich 48201, USA
    Hypertension 43:1202-7. 2004
    ....
  79. ncbi A piezo-film-based measurement system for global haemodynamic assessment
    Fabrizio Clemente
    Istituto di Ingegneria, Biomedica Consiglio Nazionale delle Ricerch, Via Salaria Km 29, 300 00016 Monterotondo S RM, Italy
    Physiol Meas 31:697-714. 2010
    ..The system was characterized by numerical simulation and experimental in vivo comparison to the traditional reference system...
  80. ncbi Left atrial volume: a powerful predictor of survival after acute myocardial infarction
    Jacob E Moller
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 107:2207-12. 2003
    ..In contrast, left atrial (LA) volume is less influenced by acute changes and reflects subacute or chronic diastolic function. This may be of importance when one assesses risk in patients with AMI...
  81. pmc Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy
    Scott J Denardo
    Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Med 123:719-26. 2010
    ..Our understanding of the growing population of very old patients (aged >or=80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes...
  82. pmc Cardiac cine MRI: Quantification of the relationship between fast gradient echo and steady-state free precession for determination of myocardial mass and volumes
    Ashkan Akhavan Malayeri
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Magn Reson Imaging 28:60-6. 2008
    ..To determine the correlation function between the steady-state free precession (SSFP) and fast gradient echo (FGRE) cine MRI pulse sequences for measuring the myocardial mass and volumes...
  83. ncbi The effect of cardiac resynchronization therapy on left ventricular diastolic function assessed with speckle-tracking echocardiography
    Miriam Shanks
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Eur J Heart Fail 13:1133-9. 2011
    ..The aims of the study were to evaluate changes in LV diastolic function with speckle-tracking echocardiography in relation to: (i) cardiac resynchronization therapy response (LV remodelling) and (ii) heart failure aetiology...
  84. pmc Changes in diastolic dysfunction in diabetes mellitus over time
    Aaron M From
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Cardiol 103:1463-6. 2009
    ..LV diastolic dysfunction is predictive of all-cause mortality in patients with DM independent of hypertension and coronary disease...
  85. ncbi Left ventricular systolic and diastolic function by echocardiogram in pseudoxanthoma elasticum
    Long Dang Nguyen
    Department of Cardiology, centre hospitalier régional d Orléans, Orleans, France
    Am J Cardiol 97:1535-7. 2006
    ..Explanations for these abnormalities could be silent myocardial ischemia due to early coronary involvement and/or the direct consequences of ultrastructural defects of the elastic tissue of the heart...
  86. pmc Iron overload in polytransfused patients without heart failure is associated with subclinical alterations of systolic left ventricular function using cardiovascular magnetic resonance tagging
    Stéphanie Seldrum
    Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    J Cardiovasc Magn Reson 13:23. 2011
    ..Therefore we performed a comprehensive evaluation of systolic and diastolic cardiac function in such patients using tagged and phase-contrast CMR...
  87. ncbi Which echocardiographic Doppler left ventricular diastolic function measurements are most feasible in the clinical echocardiographic laboratory?
    Shahabuddin Khan
    St John Hospital and Medical Center, Detroit, Michigan 48236, USA
    Am J Cardiol 94:1099-101. 2004
    ....
  88. ncbi Exercise training in systolic and diastolic dysfunction: effects on cardiac function, functional capacity, and quality of life
    Neil Smart
    University of Queensland, Brisbane, Australia
    Am Heart J 153:530-6. 2007
    ..We compared the responses of patients with exercise intolerance and SD or DD to 16 weeks of exercise training...
  89. ncbi Association of blood pressure status with the optic disk structure in non-glaucoma subjects: the Thessaloniki eye study
    Fotis Topouzis
    II Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Am J Ophthalmol 142:60-67. 2006
    ..To study the association of blood pressure (BP) status on the optic disk structure as measured with the Heidelberg Retina Tomograph (HRT) in people without glaucoma...
  90. ncbi Deteriorating glucose tolerance status is associated with left ventricular dysfunction--the Hoorn Study
    R M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Neth J Med 66:110-7. 2008
    ..We investigated, in a population-based cohort (n=746), the association between glucose tolerance status and SDF and DDF ...
  91. ncbi Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study
    S R Ommen
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 102:1788-94. 2000
    ..However, accurate prediction of filling pressures for an individual patient requires a stepwise approach incorporating all available data...
  92. pmc Long term monitoring in patients receiving treatment to lower blood pressure: analysis of data from placebo controlled randomised controlled trial
    Katherine Keenan
    Screening and Test Evaluation Program STEP, School of Public Health, Building A27, University of Sydney, New South Wales 2006, Australia
    BMJ 338:b1492. 2009
    ..To determine the value of monitoring blood pressure by quantifying the probability that observed changes in blood pressure reflect true changes...
  93. ncbi Gender differences of atrial and ventricular remodeling and autonomic tone in nonelite athletes
    Matthias Wilhelm
    Division of Cardiovascular Prevention, Rehabilitation, and Sports Cardiology, Department of Cardiology, Inselspital, University Hospital and University of Bern, Bern, Switzerland
    Am J Cardiol 108:1489-95. 2011
    ..A higher blood pressure at rest and during exercise and a higher sympathetic tone might be causal. The altered left atrial substrate might facilitate the occurrence of AF...
  94. pmc Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: an additional mechanism of diastolic dysfunction and interventricular dyssynchrony
    Ai Min Sun
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, M5G1X8, Canada
    J Cardiovasc Magn Reson 13:43. 2011
    ..While restrictive physiology in late diastole has been well known, dysfunction in early diastole has not been described...
  95. pmc Relation of arterial stiffness to diastolic dysfunction in hypertensive heart disease
    P M Mottram
    University of Queensland, Brisbane, Queensland, Australia
    Heart 91:1551-6. 2005
    ..To examine the relation of arterial compliance to diastolic dysfunction in hypertensive patients with suspected diastolic heart failure (HF)...
  96. ncbi Optimal systolic and diastolic image reconstruction windows for coronary 256-slice CT angiography
    Greta S P Mok
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong
    Acad Radiol 17:1386-93. 2010
    ....
  97. pmc Impact of left ventricular volume/mass ratio on diastolic function
    Adisai Buakhamsri
    Division of Cardiovascular Medicine, Department of Cardiology, Desk F 15, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 30:1213-21. 2009
    ..To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls...
  98. ncbi Effect of aortic valve surgery on left ventricular diastole assessed by echocardiography and neuroendocrine response: percutaneous versus surgical approach
    Fabio Guarracino
    Cardiothoracic Department, Azienda Ospedaliera Universitaria Pisana, Via Paradisa 2, 56124 Pisa, Italy
    J Cardiothorac Vasc Anesth 24:25-9. 2010
    ..The authors aimed to compare the acute effect of endovascular and surgical aortic valve procedures on left ventricular diastolic function...
  99. ncbi Myocardial bridging is associated with alteration in coronary vasoreactivity
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street S W, Rochester, MN 55905, USA
    Eur Heart J 25:2134-42. 2004
    ..Myocardial bridging is a congenital condition associated with alteration in shear stress, however, its impact upon vasoreactivity remains undetermined...
  100. ncbi Echocardiographic assessment of left ventricular diastolic function and filling pressure in atrial fibrillation
    Malik A Al-Omari
    Division of Cardiovascular Disease and Internal Medicine, Mayo Echocardiography Research Center, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Am J Cardiol 101:1759-65. 2008
    ..In conclusion, this review provides an up-to-date discussion of the evaluation of diastolic function assessment in AF and how it may be important in the clinical management of patients with AF...
  101. ncbi Myocardial tissue Doppler and long axis function in the fetal heart
    Helena M Gardiner
    Royal Brompton Hospital, UK
    Int J Cardiol 113:39-47. 2006
    ..Current echocardiographic assessment of fetal ventricular function uses relatively crude measures and this has led to inconsistencies in assessment of diastolic function. Long axis parameters may be more insightful...

Research Grants63

  1. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..a portion of stroke volume during systole, reducing systolic pressure and maintaining systemic perfusion during diastole. Common clinical conditions, including aging, insulin resistance, diabetes and hypertension per se are associated ..
  2. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..Balloon inflation/deflation will coincide with the body's own physiological properties (i.e., systole/diastole), therefore matching closely the underlying Windkessel mechanism...
  3. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..with the heart will reduce the work required by the heart during systole and unload the left ventricle during diastole. Phase I proved the feasibility of the ACD both in bench testing using a specially designed mock loop and in ..
  4. FKBP Interaction with RYR Calcium Channels in Heart
    Donald M Bers; Fiscal Year: 2013
    ..Affected RyRs are more active than normal, leaking Ca from the SR during diastole causing arrhythmias and dysfunction. FKBP12 and FKBP12...
  5. Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins
    Evangelia G Kranias; Fiscal Year: 2013
    ..SR Ca-uptake during diastole is mediated by SERCA2a and its reversible regulator phospholamban (PLN);Ca is stored by calsequestrin;and Ca is ..
  6. Restrictive Cardiomyopathy Caused by Cardiac Troponin Mutations
    Xupei Huang; Fiscal Year: 2012
    ..is a cardiac disorder characterized by a stiffened heart and reduced blood filling to the heart chambers during diastole. Heart failure and early cardiac death are observed in patients with RCM, resulting from cardiac gene mutations...
  7. Cardiomyocyte stretch and intracellular calcium release with advancing age
    TIMOTHY LEE DOMEIER; Fiscal Year: 2013
    ..This period of relaxation is the cardiac diastole, during which time the heart fills with blood and prepares for the next contraction during systole...
  8. CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEART
    Sandor Gyorke; Fiscal Year: 2013
    ..ensures that a substantial Ca reserve is maintained in the SR and prevents RyR2s from untimely opening during diastole. The central concept of this proposal is that genetic and acquired defects in components of the RyR2 channel are ..
  9. Interactions Between Inflammation, Oxidant Stress and Cardiovascular Disease
    David G Harrison; Fiscal Year: 2013
    ..to separate the effects of blood pressure lowering versus recoupling of nitric oxide synthase in improvement of diastole function...
  10. Novel calcium buffer for the treatment of diastolic heart failure
    Michelle L Asp; Fiscal Year: 2013
    ..patients hve diastolic heart failure (DHF), resulting from slow or incomplete relaxation of the heart muscle in diastole. Calcium (Ca2+) mishandling by cardiac myocytes is an important contributor to DHF...
  11. 4D MRI Development for Cardiovascular Imaging
    Jing Liu; Fiscal Year: 2013
    ..Whole-heart coronary MRA centered on mid-diastole has also been demonstrated without contrast injection...
  12. Myocardial Stiffness in Diastolic Heart Failure
    Kenneth S Campbell; Fiscal Year: 2012
    ..is the sum of an 'active'stiffness component (due to myosin heads that continue to cycle during diastole) and a 'passive'stiffness component (attributed to titin, collagen, elastin and intermediate filaments)...
  13. FUNCTION OF GIANT SARCOMERE MATRIX PROTEINS IN MUSCLE
    Henk L Granzier; Fiscal Year: 2013
    ..multiple important functions, including that of a molecular spring that develops passive stiffness during diastole. We have shown that titin-based passive stiffness is adjustable through differential splicing and post-..
  14. Single Molecule Studies of Titin Elasticity
    Julio M Fernandez; Fiscal Year: 2013
    ..The filling with blood o the left ventricle of the human heart during diastole, and its subsequent ability to eject it throuh the aorta, is dependent on the elasticity of titin...
  15. NMR Structural Analysis of Calcium Regulation in Muscle
    Gianluigi Veglia; Fiscal Year: 2013
    ..myocytes, the SR Ca2+-ATPase 2a isoform (SERCA2a) is responsible for ~70% of the Ca2+ translocation and regulates diastole. SERCA2a is inhibited by phospholamban (PLN), a membrane protein that reverses its inhibition upon ..
  16. Stretch-dependent X-ROS signaling: implications for cardiomyopathy
    BENJAMIN LEARS PROSSER; Fiscal Year: 2013
    ..A novel signaling pathway in heart cells, termed X-ROS signaling, links the lengthening of a heart cell during diastole to the generation of reactive oxygen species (ROS) and subcellular Ca2+ signaling (Prosser et al., Science 2011)...
  17. Stretch-Dependent Calcium Signaling in Heart
    WILLIAM JONATHAN LEDERER; Fiscal Year: 2013
    Abstract Ca2+ sparks in heart have been shown by the PI to occur under physiological conditions during diastole and systole...
  18. Structural Basis of Ventricular Function
    Xin Yu; Fiscal Year: 2010
    ..the structural basis of myocardial wall thickening by directly assessing myocardial structural changes from diastole to systole...
  19. Portable pneumatic driver for counterpulsation therapy
    Paul A Spence; Fiscal Year: 2010
    ..The CPD fills during native heart systole lowering ventricular workload, and ejects during diastole augmenting myocardial and end-organ perfusion...
  20. Function and Regulation of HCN Channels in Sinoatrial Myocytes
    Catherine Proenza; Fiscal Year: 2012
    ..There are three specific aims: (1) To understand the biophysical mechanisms for HCN channel activity during diastole, (2) To describe the functional relationships between 2ARs and HCN channels that control firing rate in ..
  21. Structural Basis of Dilated Cardiomyopathy
    Gianluigi Veglia; Fiscal Year: 2013
    ..PLN binds and inhibits the SR Ca-ATPase (SERCA), regulating heart diastole. PLN phosphorylation at Ser16 by protein kinase A (PKA) reverses the inhibitory effects, constituting the primary ..
  22. Counterpulsation Device with Integrated ECG Sensing
    Robert D Dowling; Fiscal Year: 2010
    ..The CPD fills with blood during native heart systole lowering ventricular workload, and ejects during diastole augmenting myocardial and end-organ perfusion...
  23. Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic Function
    Himanshu Gupta; Fiscal Year: 2013
    ..Torsional recoil during isovolumic relaxation and early diastole releases the potential energy stored in the deformed matrix during systole and thus is also dependent on systolic ..
  24. Counterpulsation Device with Integrated EKG System for Chronic Partial Circulator
    Paul A Spence; Fiscal Year: 2013
    ..Symphony is timed with the EKG to fill during systole and eject during diastole. Recent work in a Phase 1 study demonstrated subcutaneous EKG leads were as effective as epicardial leads for QRS ..
  25. Development of an Image Driven Mechanical Model of the Left Ventricle
    ALEXANDER ISTVAN VERESS; Fiscal Year: 2010
    ..wall thickening measures, are indirect measures of left ventricular tissue contraction (systole) and dilation (diastole)...
  26. Non-Invasive Monitoring of Central Blood Pressure in Humans
    Ramakrishna Mukkamala; Fiscal Year: 2013
    ..subject at the time of measurement by exploiting the fact that ascending aortic blood flow is negligible during diastole, will be rigorously investigated in humans as a follow-up to successful animal testing...
  27. Quantitative cardiac MRI perfusion for longitudinal studies
    EDWARD VR DI BELLA; Fiscal Year: 2013
    ..of the proposed quantitative methods and the differences in perfusion and MPR measured at systole and diastole, including determining if systole or diastole is most repeatable when quantifying perfusion...
  28. Surgical Planning Tool for Aortic Valve Reconstruction
    Pedro J del Nido; Fiscal Year: 2013
    ..leaflets using non-leaflet tissue (pericardium treated with gluteraldehyde) to generate valve closure during diastole. While experienced surgeons are able to do this intra-operatively, consistent results and widespread application ..
  29. Measuring the Efficacy of Endovascular Treatment of AAA
    Peter Faries; Fiscal Year: 2007
    ..sac will be correlated with the change in the cross-sectional area and volume of the aneurysm during systole and diastole using cine magnetic resonance imaging...
  30. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Once these cells mature into an adult phenotype they will be paced to contract at the time of the host's diastole to simulate an intraaortic balloon counterpulsation device...
  31. FUNCTIONAL CHARACTERISTICS OF THE LEFT HEART
    HAROLD DODGE; Fiscal Year: 1990
    ..thrombolytic therapy in myocardial infarction, (3) regional abnormalities of timing of motion during systole and diastole, the relationship of these abnormalities to global ventricular performance and to conduction defects in the ..
  32. Development of a Counterpulsation Therapy Device
    Paul Spence; Fiscal Year: 2009
    ..The CPD fills during native heart systole lowering ventricular workload, and ejects during diastole augmenting myocardial and end-organ perfusion...
  33. DIASTOLIC PROPERTIES OF DEVELOPING MYOCARDIUM
    Kent Thornburg; Fiscal Year: 1993
    ..The purpose of this application is to investigate the cellular and functional aspects of diastole in growing lambs...
  34. MECHANICAL FACTORS AND ENERGY LOSS IN MYOCARDIAL REGIONS
    Joseph Kedem; Fiscal Year: 2001
    ..ventricular energy loss, since segment shortening of post-ischemic myocardium continues well into ventricular diastole. Finally, it is proposed that efficiency will be improved by agents that improve contraction and relaxation ..
  35. EFFECTS OF CARDIO ACTIVE AGENTS ON CARDIAC MYOCYTES
    RONALD ARONSON; Fiscal Year: 1992
    ..oscillations of current, (2) Changes in the net conductance of the membrane during repolarization and during diastole, (3) The contribution of changes in the magnitude of kinetics of calcium currents...
  36. L-type Channel Calcium Entry Triggered Diastolic Calcium Sparks
    WILLIAM CECIL LESTER; Fiscal Year: 2010
    ..Calcium may enter the cytosol during diastole via PM leak, and via unitary releases of calcium from intracellular stores - labeled as calcium sparks...
  37. 3-D ANALYSIS OF LEFT VENTRIULAR REGIONAL WALL MOTION
    R Clark; Fiscal Year: 1990
    ..data for this package will be obtained from magnetic resonance images (MRI) of patients' hearts taken at end-diastole and end-systole...
  38. Development and Evaluation of MRI Methods to Assess Diastolic Function
    Leon Axel; Fiscal Year: 2012
    ..However, it has still been relatively little applied to the evaluation of diastole, the relaxation phase of the cardiac cycle, which can be affected before systole, the more commonly evaluated ..
  39. MECHANISMS OF CRUSTACEAN CARDIAC SUSPENSORY LIGAMENTS
    MALCOLM DEMONT; Fiscal Year: 1993
    ..The elastic system functions to assist in refilling the heart during diastole by releasing the strain energy that is stored in the connective tissue as the wall of the heart thickens during ..
  40. ALTERED CALCIUM REGULATION IN CARDIOMYOPATHIES
    P Chase; Fiscal Year: 2004
    ..that R162W, K183delta, G203S and K206Q could all compromise the ability of cTn to relax the myocardium during diastole. Recombinant cTnI constructs will be altered with mutations found in FHC...
  41. INFLUENCE OF FLOW DYNAMICS ON THROMBOGENESIS
    RICHARD SCHOEPHOERSTER; Fiscal Year: 1991
    ..A numerical model simulating blood flow, both laminar and turbulent, in the left ventricle during diastole will be developed, which can be used to quantify the detailed flow dynamics in the vicinity of various geometries ..
  42. VENTRICULAR SYSTOLIC INTERACTIONS DURING HEART FAILURE
    David Farrar; Fiscal Year: 1993
    ..LV apex of anesthetized pigs will be connected to a prosthetic ventricle which is timed to fill immediately after diastole. Hearts will be studied from normal pigs and after heart failure is produced with our model of rapid ventricular ..
  43. Treatment of Heart Disease with an Intraventricular Sac
    ZHENFANG ZHANG; Fiscal Year: 2006
    ..placed inside the left ventricle of a diseased heart, and functions by limiting filling of the ventricle during diastole. The divola protects the left ventricle from the harmful effects of high ventricular pressure during diastole, ..
  44. DRUG EFFECTS ON IMPULSE INITIATION IN THE HEART
    KENNETH DANGMAN; Fiscal Year: 1991
    ..single cell/cell cluster experiments should permit us to determine whether time-dependent decreases of g R, sufficient to explain phase 4 depolarization, occur as a consequence of progressive declines of [K+]c and [Ca++]i during diastole.
  45. Combination Ventricular Restraint Therapy and Stem Cell Therapy For Heart Failure
    SUYOG MOKASHI; Fiscal Year: 2009
    ..In restraint therapy, a promising mechanical treatment, pressure is applied to the ventricle during end- diastole to reduce myocardial wall stress and reverse ventricular remodeling...
  46. PHONOANGIOGRAPHIC SPECTRAL ANALYZER FOR CORONARY ARTERY
    KENNETH SCHLAGER; Fiscal Year: 1991
    ..This interference can be minimized, however, by proper timing of PSA measurement during diastole when coronary stenotic sounds are loudest and background sounds are at a minimum...
  47. Structure function and ligand binding of a novel peptide involved in cardiac rela
    Ruthann Nichols; Fiscal Year: 2009
    ..We determined that hRFRP-1, human RFamide-related peptide-1, slows cardiac relaxation, a component of diastole. This is an exciting finding as it identifies a potential endogenous signaling agent that could contribute to ..
  48. VENTRICULAR DYNAMICS FROM SURGICALLY INSERTED MARKERS
    D Miller; Fiscal Year: 2007
    ..limitation of normal fiber and chamber recoil mechanisms required to augment LV compliance rapidly in earliest diastole, thereby facilitating active LV filling at a low left atrial pressures; 3...
  49. CARDIOMYOCYTE MECHANOTRANSDUCTION AND THE CARDIAC CYCLE
    Richard Lee; Fiscal Year: 2001
    ..categorized as "pressure" overload (mechanical overload in systole) or volume overload (mechanical overload in diastole). Pressure overload and volume overload are associated with distinct morphologic and molecular responses...
  50. Role of EMT in Cardiac Fibrosis
    Elisabeth Zeisberg; Fiscal Year: 2006
    ..Thus, relaxation (diastole) of the heart is disturbed, and the filling of the heart impaired...
  51. EXCITABILITY AND CONDUCTION IN VENTRICULAR MYOCYTES
    Mario Delmar; Fiscal Year: 1990
    ..Study the passive membrane properties of single cells and characterize the changes in their excitability during diastole. 2) Study the ionic mechanisms responsible for post-repolarization refractoriness and rate-dependent failure of ..
  52. LEFT VENTRICULAR WALL MOTION ANALYSIS
    Paul Clayton; Fiscal Year: 1980
    ..This will be done by analyzing ventricular motion throughout systole and diastole in groups of patients with different pathological conditions (normal, ischemic, and fibrotic myocardium) ..
  53. Cardiac Synchronization Technology for PEA Patients
    JON VONOHLSEN; Fiscal Year: 2005
    ..chest during intrinsic contractions -- and relaxing so as to allow adequate ventricular filling during intrinsic diastole. In response to NIH Program Announcement (PA) 04-059 - Technologies for Monitoring and Performing Resuscitation, ..
  54. ROBUST CONTRAST FOR AUTO--ANALYSIS OF CARDIAC MRI
    John Oshinski; Fiscal Year: 2000
    ..Comparisons would include endocardial areas and volumes in the left and right ventricles, ejection fractions, the peak rates of ejection and filling, and the times at which end systole, end diastole, and the peak flow rates occur.
  55. HARMONIC PHASE MRI FOR ULTRAFAST CARDIAC STRAIN IMAGING
    Jerry Prince; Fiscal Year: 2007
    ..the entire ventricular system including the right ventricle and throughout the entire cardiac cycle including diastole. The harmonic phase (HARP) MR imaging approach has been shown to be a flexible, accurate, and robust approach ..
  56. CORONARY CIRCULATORY CONTROL AND PATHOPHYSIOLOGY
    Robert Mates; Fiscal Year: 1991
    ..Project II continues ongoing studies of coronary input impedance, extending observations during diastole to the full cardiac cycle and also addressing systolic-diastolic flow interactions, effects of intramyocardial ..
  57. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  58. Neurohormonal Blockade and Outcomes in Diastolic Heart Failure
    Ali Ahmed; Fiscal Year: 2010
    ..The proposed study will examine the effect of neurohormonal blockade in propensity matched OPTIMIZE-HF participants with diastolic heart failure. ..
  59. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  60. Heart Failure and Beta-Blocker Use in Older Adults
    Ali Ahmed; Fiscal Year: 2006
    ..abstract_text> ..
  61. Expert Visual Guidance of Ultrasound for Telemedicine
    Florence Sheehan; Fiscal Year: 2006
    ..Specific Aim #4 is to make the guidance easily applicable to different organs. [unreadable] [unreadable]..
  62. Heart failure, chronic kidney disease, and renin-angiotensin system inhibition
    Ali Ahmed; Fiscal Year: 2009
    ....
  63. Adiponectin and Cardiovascular Disease in the CKiD Children
    Mark Mitsnefes; Fiscal Year: 2009
    ....