myocardial contraction

Summary

Summary: Contractile activity of the MYOCARDIUM.

Top Publications

  1. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
  2. ncbi Cardiac excitation-contraction coupling
    Donald M Bers
    Department of Physiology, Stritch School of Medicine, Loyola Unversity Chicago, IL 60153, USA
    Nature 415:198-205. 2002
  3. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  4. ncbi Calcium cycling and signaling in cardiac myocytes
    Donald M Bers
    Department of Physiology and Cardiovascular Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Annu Rev Physiol 70:23-49. 2008
  5. ncbi Oestrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia-reperfusion
    Qin Wu
    Department of Physiology, Xuzhou Medical College, West Huaihai Road 84, Xuzhou, Jiangsu 221002, China
    Exp Physiol 93:1034-43. 2008
  6. ncbi Regulation of cardiac contractile function by troponin I phosphorylation
    Joanne Layland
    Cardiovascular Division, King s College, London SE5 9PJ, UK
    Cardiovasc Res 66:12-21. 2005
  7. ncbi Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging
    Brage H Amundsen
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    J Am Coll Cardiol 47:789-93. 2006
  8. ncbi Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
    Amy J Sehnert
    Department of Biochemistry and Biophysics, University of California at San Francisco, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143 0448, USA
    Nat Genet 31:106-10. 2002
  9. ncbi Relation between the pacing induced sequence of activation and left ventricular pump function in animals
    Frits W Prinzen
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Pacing Clin Electrophysiol 25:484-98. 2002
  10. pmc Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging
    F W Prinzen
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    J Am Coll Cardiol 33:1735-42. 1999

Detail Information

Publications317 found, 100 shown here

  1. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
    ..We evaluated its effects on morbidity and mortality...
  2. ncbi Cardiac excitation-contraction coupling
    Donald M Bers
    Department of Physiology, Stritch School of Medicine, Loyola Unversity Chicago, IL 60153, USA
    Nature 415:198-205. 2002
    ..Furthermore, spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function...
  3. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  4. ncbi Calcium cycling and signaling in cardiac myocytes
    Donald M Bers
    Department of Physiology and Cardiovascular Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Annu Rev Physiol 70:23-49. 2008
    ..Importantly, although such diverse Ca-dependent regulations occur simultaneously in a cell, the cell can distinguish distinct signals by local Ca or protein complexes and differential Ca signal integration...
  5. ncbi Oestrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia-reperfusion
    Qin Wu
    Department of Physiology, Xuzhou Medical College, West Huaihai Road 84, Xuzhou, Jiangsu 221002, China
    Exp Physiol 93:1034-43. 2008
    ....
  6. ncbi Regulation of cardiac contractile function by troponin I phosphorylation
    Joanne Layland
    Cardiovascular Division, King s College, London SE5 9PJ, UK
    Cardiovasc Res 66:12-21. 2005
    ..This review focuses on recent advances in understanding the mechanisms of cTnI modification by these kinases and the consequent functional effects both under physiological conditions and in pathophysiological settings...
  7. ncbi Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging
    Brage H Amundsen
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    J Am Coll Cardiol 47:789-93. 2006
    ....
  8. ncbi Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
    Amy J Sehnert
    Department of Biochemistry and Biophysics, University of California at San Francisco, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143 0448, USA
    Nat Genet 31:106-10. 2002
    ....
  9. ncbi Relation between the pacing induced sequence of activation and left ventricular pump function in animals
    Frits W Prinzen
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Pacing Clin Electrophysiol 25:484-98. 2002
    ..These experimental findings justify continuing attention for optimizing the site(s) of ventricular pacing in patients with normal and abnormal ventricular impulse conduction...
  10. pmc Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging
    F W Prinzen
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    J Am Coll Cardiol 33:1735-42. 1999
    ..The purpose of this study was to determine the spatial distribution of myocardial function (myofiber shortening and work) within the left ventricular (LV) wall during ventricular pacing...
  11. ncbi Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring
    Tony Stanton
    School of Medicine, University of Queensland, Brisbane, Australia
    Circ Cardiovasc Imaging 2:356-64. 2009
    ..The aim of this study was to compare global longitudinal speckle strain (GLS), an automated technique for measurement of long-axis function, with EF and WMSI for the prediction of mortality...
  12. ncbi Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function
    Vicky Y Wang
    Auckland Bioengineering Institute, University of Auckland, Level 6, UniServices House, 70 Symonds Street, Auckland 1142, New Zealand
    Med Image Anal 13:773-84. 2009
    ....
  13. pmc A mathematical treatment of integrated Ca dynamics within the ventricular myocyte
    Thomas R Shannon
    Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois, USA
    Biophys J 87:3351-71. 2004
    ..We conclude that this model is more robust than many previously existing models and reproduces many experimental results using parameters based largely on experimental measurements in myocytes...
  14. pmc Cardiovascular magnetic resonance myocardial feature tracking detects quantitative wall motion during dobutamine stress
    Andreas Schuster
    King s College London British Heart Foundation Centre of Excellence, London, UK
    J Cardiovasc Magn Reson 13:58. 2011
    ..We sought to determine the feasibility and reproducibility of CMR-FT for quantitative wall motion assessment during intermediate dose DS-CMR...
  15. pmc Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy
    Khalid Chakir
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 119:1231-40. 2009
    ..The mechanical impact of CRT is immediate and well documented, yet its long-term influences on myocyte function and adrenergic modulation that may contribute to its sustained benefits are largely unknown...
  16. pmc Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium
    Regis R Lamberts
    Department of Anesthesiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center VUmc, 1081 BT Amsterdam, The Netherlands
    J Physiol 582:695-709. 2007
    ..We propose a novel role for PKC-mediated TnI phosphorylation in modulating the force-frequency relation...
  17. pmc Measurement and analysis of sarcomere length in rat cardiomyocytes in situ and in vitro
    G Bub
    Department of Physiology Anatomy and Genetics, Universityof Oxford, Oxfordshire, UK
    Am J Physiol Heart Circ Physiol 298:H1616-25. 2010
    ....
  18. ncbi Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure
    Natale P L Rolim
    School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
    Physiol Genomics 29:246-52. 2007
    ..Thus, we provide evidence that Ca(2+) handling is impaired in this HF model and that overall VF improved upon ET, which was associated to changes in the net balance of cardiac Ca(2+) handling proteins...
  19. pmc Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere
    Paul M L Janssen
    Department of Physiology and Cell Biology and D Davis Heart Lung Institute, College of Medicine, The Ohio State University, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 299:H1092-9. 2010
    The regulation of myocardial contraction and relaxation kinetics is currently incompletely understood...
  20. ncbi Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony
    C L Grines
    Department of Internal Medicine, Ohio State University, Columbus
    Circulation 79:845-53. 1989
    ..This loss of septal contribution resulted in a reduction in global ejection fraction in LBBB compared to normals (54 +/- 7% compared with 62 +/- 5%, p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)..
  21. pmc Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
    S Engelhardt
    Institut fur Pharmakologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 96:7059-64. 1999
    ..We conclude that overexpression of beta1-adrenergic receptors in the heart may lead to a short-lived improvement of cardiac function, but that increased beta1-adrenergic receptor signalling is ultimately detrimental...
  22. ncbi Global 2-dimensional strain as a new prognosticator in patients with heart failure
    Goo Yeong Cho
    Department of Medicine, Seoul National University, Seoul, South Korea
    J Am Coll Cardiol 54:618-24. 2009
    ..We sought to evaluate whether global 2-dimensional (2D) strain offers additional benefit over left ventricular ejection fraction (LVEF) to predict clinical events in heart failure...
  23. pmc Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart
    Alexander R Lyon
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 106:6854-9. 2009
    ..This study confirms the loss of T-tubules as part of the phenotypic change in the failing human myocyte, but it also shows that this is part of a wider spectrum of alterations in surface morphology...
  24. ncbi Age-associated changes in excitation-contraction coupling are more prominent in ventricular myocytes from male rats than in myocytes from female rats
    Susan E Howlett
    Department of Pharmacology and Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Physiol Heart Circ Physiol 298:H659-70. 2010
    ..Increased SR Ca(2+) content may compensate for reduced Ca(2+) current to preserve contractile function in aged females, which may limit the detrimental effects of age on cardiac contractile function...
  25. ncbi PKC-alpha regulates cardiac contractility and propensity toward heart failure
    Julian C Braz
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Nat Med 10:248-54. 2004
    ..Thus, PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca(2+) and signal transduction events, which can profoundly affect propensity toward heart failure...
  26. pmc Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart
    Chuanchau J Jou
    Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT 84113, USA
    Cell Physiol Biochem 25:419-24. 2010
    ..In this study, we compared the effects two uncoupling agents, 2,3-Butanedione monoxime (BDM) and blebbistatin, on contractility and AP parameters in embryonic zebrafish heart...
  27. ncbi Sex differences in mechanisms of cardiac excitation-contraction coupling in rat ventricular myocytes
    Spring R Farrell
    Department of Pharmacology, Dalhousie University, 5850 College St, Halifax, Nova Scotia, Canada
    Am J Physiol Heart Circ Physiol 299:H36-45. 2010
    ..Thus, differences in cardiac contractile function arise, in part, from differences in unitary Ca(2+) release between the sexes...
  28. ncbi Quantitative assessment of the SR Ca2+ leak-load relationship
    Thomas R Shannon
    Department of Physiology, Loyola University Chicago, Maywood, IL 60153, USA
    Circ Res 91:594-600. 2002
    ....
  29. pmc A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function
    Sakthivel Sadayappan
    Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, IL, USA
    Circ Res 109:141-50. 2011
    ..In vitro and in vivo experiments suggest the nonequivalence of these sites and the potential importance of Ser-282 phosphorylation in modulating the protein's overall phosphorylation and myocardial function...
  30. pmc Impact of temperature on cross-bridge cycling kinetics in rat myocardium
    Pieter P de Tombe
    Center for Cardiovascular Research, Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60607 7171, USA
    J Physiol 584:591-600. 2007
    ..Tension cost, on the other hand, is determined solely by cross-bridge detachment kinetics at all temperatures and levels of contractile activation...
  31. ncbi New Doppler echocardiographic applications for the study of diastolic function
    M J Garcia
    Cardiovascular Imaging Center, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 32:865-75. 1998
    ..This review will focus on the complementary role of color M-mode and tissue Doppler echocardiography and traditional Doppler indices of LV filling and PV flow in the assessment of diastolic function...
  32. ncbi Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation
    Jun Ren
    Division of Pharmaceutical Sciences, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Am J Physiol Heart Circ Physiol 284:H1800-7. 2003
    ..Ovx reduced myocyte Ca(2+) responsiveness and lessened stimulating frequency-induced decline in PS, both ablated by E(2). These data suggest that mechanical and protein functions of ventricular myocytes are directly regulated by E(2)...
  33. pmc Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy
    Lin Zhang
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Diabetes 57:2158-66. 2008
    ..This study examines the extent to which the contractile deficit of diabetic cardiomyopathy is due to altered Ca(2+) homeostasis...
  34. ncbi Phosphorylation and function of cardiac myosin binding protein-C in health and disease
    David Barefield
    Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    J Mol Cell Cardiol 48:866-75. 2010
    ....
  35. pmc Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations
    John Jeremy Rice
    IBM T J Watson Research Center, Yorktown Heights, New York, USA
    Biophys J 95:2368-90. 2008
    ..The combined model also demonstrates that the feedback effects of force on Ca binding to troponin can modify the cytosolic Ca transient...
  36. ncbi Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice
    Scott A Grandy
    Dept of Pharmacology, 5850 College St, Sir Charles Tupper Medical Bldg, Dalhousie Univ, Halifax, NS, B3H 1X5, Canada
    Am J Physiol Heart Circ Physiol 291:H2362-70. 2006
    ....
  37. ncbi Transient exposure to hydrogen peroxide causes an increase in mitochondria-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in ventricular myocytes
    Helena M Viola
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia
    Circ Res 100:1036-44. 2007
    ..The effect persists because a positive feedback exists among increased basal channel activity, elevated intracellular calcium, and superoxide production by the mitochondria...
  38. ncbi Effects of gender on intracellular
    C L Curl
    Department of Physiology, Monash University, Victoria, Australia
    Pflugers Arch 441:709-16. 2001
    ..The data demonstrate that, under a variety of conditions, intracellular [Ca2+] rises to higher levels in cardiac myocytes from male as compared to female rats...
  39. ncbi Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase A
    Gennadi M Kravtsov
    Department of Physiology, 4 F Laboratory Block, Faculty of Medicine Bldgs, 21 Sassoon Rd, Pokfulam, Hong Kong SAR, China
    Am J Physiol Cell Physiol 292:C1625-35. 2007
    ..The increased release of Ca(2+) through RyR and removal of Ca(2+) by NCX are believed to be responsible for the greater contractility and faster relaxation after Ovx...
  40. ncbi Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats
    Kin M Choi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Heart Circ Physiol 283:H1398-408. 2002
    ..The increase in phospholamban, decrease in Na(+)/Ca(2+) exchanger, and unchanged L-type Ca(2+) channel activity in this model of diabetic cardiomyopathy are distinct from other types of cardiomyopathy...
  41. pmc Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
    Albertas I Undrovinas
    Heart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    J Cardiovasc Electrophysiol 17:S169-S177. 2006
    ....
  42. ncbi Sarcoplasmic reticulum Ca2+-ATPase modulates cardiac contraction and relaxation
    Konrad F Frank
    Clinic III of Internal Medicine, Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Cologne, Germany
    Cardiovasc Res 57:20-7. 2003
    ....
  43. ncbi Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis
    Feng Dong
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Diabetes 56:2201-12. 2007
    ..These data suggest that metallothionein may protect against high-fat diet-induced cardiac dysfunction possibly associated with upregulation of PGC-1alpha and preservation of mitochondrial biogenesis...
  44. ncbi Cardiac systolic rotation and contraction before and after valve replacement for aortic stenosis: a myocardial tagging study using MR imaging
    Joern J W Sandstede
    Institut für Röntgendiagnostik and Medizinische Klinik, Universitat Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    AJR Am J Roentgenol 178:953-8. 2002
    ....
  45. pmc Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy
    Kenneth C Bilchick
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    JACC Cardiovasc Imaging 1:561-8. 2008
    ....
  46. ncbi Dystrophic heart failure blocked by membrane sealant poloxamer
    Soichiro Yasuda
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
    Nature 436:1025-9. 2005
    ....
  47. pmc Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction
    Rui Guo
    Department of Biochemistry and Molecular Biology, Hebei University College of Life Sciences, Baoding 071002, China
    J Mol Cell Cardiol 47:228-37. 2009
    ..Taken together, these data suggested that ER stress occurs likely downstream of oxidative stress en route to cardiac dysfunction...
  48. pmc Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development
    Brett A Colson
    Department of Physiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53711, USA
    J Physiol 588:981-93. 2010
    ....
  49. pmc Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction
    Asli F Ceylan-Isik
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    J Mol Cell Cardiol 50:107-16. 2011
    ..In summary, these data depicted a pivotal role of ER stress in obesity-associated cardiac contractile dysfunction, suggesting the therapeutic potential of ER stress as a target in the management of cardiac dysfunction in obesity...
  50. pmc Cardiac myosin-binding protein-C phosphorylation and cardiac function
    Sakthivel Sadayappan
    Division of Molecular Cardiovascular Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH, USA
    Circ Res 97:1156-63. 2005
    ..In contrast, when the MyBP-C(t/t) mice were bred to a TG line expressing normal MyBP-C (MyBP-CWT), the MyBP-C(t/t) phenotype was rescued. These data suggest that cMyBP-C phosphorylation is essential for normal cardiac function...
  51. pmc Myocardial contraction-relaxation coupling
    Paul M L Janssen
    Department of Physiology and Cell Biology and D Davis Heart Lung Institute, College of Medicine, The Ohio State University, Columbus, Ohio 43210 1218, USA
    Am J Physiol Heart Circ Physiol 299:H1741-9. 2010
    ....
  52. pmc Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging
    Partho P Sengupta
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 20:539-51. 2007
    ..This review examines the structure and function of the left ventricle relative to the potential clinical application of DTI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo...
  53. ncbi Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium
    Samuel Sossalla
    Department of Cardiology and Pneumology, Georg August University Gottingen, Gottingen, Germany
    J Am Coll Cardiol 55:2330-42. 2010
    ..We investigated changes in Na(+) currents (I(Na)) in permanent (or chronic) atrial fibrillation (AF) and the effects of I(Na) inhibition using ranolazine (Ran) on arrhythmias and contractility in human atrial myocardium...
  54. ncbi Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure
    Andrew E Messer
    National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    J Mol Cell Cardiol 42:247-59. 2007
    ..35-0.75). We suggest that changes in troponin function can account for the contractile abnormality in failing heart muscle and that the functional changes in troponin are due to reduced phosphorylation of troponin I at the PKA sites...
  55. ncbi What mechanisms underlie diastolic dysfunction in heart failure?
    David A Kass
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circ Res 94:1533-42. 2004
    ..This review puts these developments into perspective with the major aim of highlighting current knowledge gaps and controversies...
  56. ncbi Detailed analysis of myocardial motion in volunteers and patients using high-temporal-resolution MR tissue phase mapping
    Bernd Jung
    Department of Diagnostic Radiology, Medical Physics, University Hospital, Freiburg, Germany
    J Magn Reson Imaging 24:1033-9. 2006
    ..To detect and investigate details in left ventricular (LV) motion patterns with a temporal resolution comparable to that of echocardiography...
  57. pmc Neonatal mouse-derived engineered cardiac tissue: a novel model system for studying genetic heart disease
    W J De Lange
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Circ Res 109:8-19. 2011
    ..Development of a murine ECT would provide access to many existing models of cardiac disease and open the possibility of performing targeted genetic manipulation with the ability to directly assess contractile and molecular variables...
  58. pmc CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation
    Eckard Picht
    Department of Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    J Mol Cell Cardiol 42:196-205. 2007
    ..Thus SR-targeted CaMKII inhibition can directly inhibit the activation of SR Ca(2+) uptake, SR Ca(2+) release and I(Ca) by CaMKII, effects which have all been implicated in triggered arrhythmias...
  59. ncbi Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
    Wolfram Hubertus Zimmermann
    Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg Eppendorf, Germany
    Nat Med 12:452-8. 2006
    ..Thus, our study provides evidence that large contractile cardiac tissue grafts can be constructed in vitro, can survive after implantation and can support contractile function of infarcted hearts...
  60. ncbi Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts
    Vadim V Fedorov
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130 4899, USA
    Heart Rhythm 4:619-26. 2007
    ..Application of fluorescence imaging of cardiac electrical activity is limited by motion artifacts and/or side effects of currently available pharmacologic excitation-contraction uncoupling agents...
  61. pmc An analysis of deformation-dependent electromechanical coupling in the mouse heart
    Sander Land
    Department of Computer Science, University of Oxford, Oxford, UK
    J Physiol 590:4553-69. 2012
    ....
  62. pmc Comprehensive cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSE
    Xiaodong Zhong
    MR R and D Collaborations, Siemens Healthcare, Atlanta, USA
    J Cardiovasc Magn Reson 13:83. 2011
    ..Quantitative noninvasive imaging of myocardial mechanics in mice enables studies of the roles of individual genes in cardiac function. We sought to develop comprehensive three-dimensional methods for imaging myocardial mechanics in mice...
  63. pmc Mineralocorticoid receptor activation is crucial in the signalling pathway leading to the Anrep effect
    Claudia I Caldiz
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    J Physiol 589:6051-61. 2011
    ..Our results suggest that MR activation is a necessary step in the stretch-triggered reactive oxygen species-mediated activation of redox-sensitive kinases upstream NHE-1...
  64. pmc Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury
    Dennis Ladage
    Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA
    Circ Res 109:1396-400. 2011
    ..Pharmacological inhibition of PKCα/β with Ro-32-0432, Ro-31-8220 or ruboxistaurin (LY333531) similarly enhances cardiac function and antagonizes heart failure in multiple models of disease in both mice and rats...
  65. ncbi Role of autocrine/paracrine mechanisms in response to myocardial strain
    Horacio E Cingolani
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Calle 60 y 120, 1900, La Plata, Argentina
    Pflugers Arch 462:29-38. 2011
    ..The evidence for each step of the intracellular signaling pathway leading to the development of SFR and their relationship with the mechanisms proposed for cardiac hypertrophy development will be analyzed...
  66. ncbi Intracellular free zinc during cardiac excitation-contraction cycle: calcium and redox dependencies
    Erkan Tuncay
    Department of Biophysics, Faculty of Medicine, Ankara University, Ankara 06100, Turkey
    Cardiovasc Res 89:634-42. 2011
    ..In cardiomyocytes at rest, Zn(2+) concentration is in the nanomolar range. Very little is known about precise mechanisms controlling the intracellular distribution of Zn(2+) and its variations during cardiac function...
  67. pmc Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice
    PETER P CHEN
    Department of Cellular and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, 601 Science Dr, Madison, WI 53711, USA
    Circulation 126:1194-205. 2012
    ....
  68. ncbi Passive mechanical properties of cardiac tissues in heart hypertrophy during pregnancy
    Adolfo Virgen-Ortiz
    Departamento de Ciencias Químico Biológicas, Unidad Regional Sur Campus Navojoa, Universidad de Sonora, Blvd Lázaro Cárdenas No 100, Colonia Francisco Villa, 85880, Navojoa, Sonora, Mexico
    J Physiol Sci 59:391-6. 2009
    ..In conclusion, a heart with less ventricular rigidity could contribute to facilitating the ventricular filling in conditions of a greater circulating volume characteristic of pregnancy...
  69. ncbi Angiotensin II: a regulator of cardiomyocyte function and survival
    Julieta Palomeque
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata 1900, Argentina
    Front Biosci (Landmark Ed) 14:5118-33. 2009
    ..To identify new therapeutic molecular targets in heart failure, further work is required to clearly establish the signalling events involved in Ang II inotropic and apoptotic signalling and the potential link between them...
  70. pmc Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis
    Asli F Ceylan-Isik
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    Hypertension 53:1023-31. 2009
    ..Our data suggest a role for BH4 deficiency in cardiac dysfunction and the therapeutic potential of antioxidants against eNOS uncoupling in the heart...
  71. pmc Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender
    Daniel Augustine
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:8. 2013
    ..We used it to record deformation parameters in healthy adults and compared values to those obtained by tagging...
  72. ncbi Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction
    Sabine J Van Dijk
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 119:1473-83. 2009
    ..In the present study, we investigated whether protein composition and function of the sarcomere are altered in a homogeneous familial hypertrophic cardiomyopathy patient group with frameshift mutations in MYBPC3 (MYBPC3(mut))...
  73. ncbi Motion in cardiovascular MR imaging
    Andrew D Scott
    Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital, London, England
    Radiology 250:331-51. 2009
    ..Similarly, for respiratory motion of the heart, techniques such as breath holding, respiratory gating, section tracking, phase-encoding ordering, subject-specific translational models, and a range of new techniques are considered...
  74. pmc Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats
    Christopher R Wilson
    Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1 246, Houston, TX 77030, USA
    Biochem J 406:457-67. 2007
    ..In conclusion, we implicate inadequate induction of a cassette of fatty acid-responsive genes, and impaired activation of fatty acid oxidation, in the development of cardiac dysfunction with Western diet...
  75. pmc Development of dilated cardiomyopathy in Bmal1-deficient mice
    Mellani Lefta
    Center for Muscle Biology, University of Kentucky, Lexington, Kentucky 40536, USA
    Am J Physiol Heart Circ Physiol 303:H475-85. 2012
    ....
  76. ncbi Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis
    Kan N Hor
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    JACC Cardiovasc Imaging 3:144-51. 2010
    ....
  77. ncbi Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization
    S V Koushik
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912 2640, USA
    FASEB J 15:1209-11. 2001
  78. ncbi Hypothermia increases the gain of excitation-contraction coupling in guinea pig ventricular myocytes
    Robin H Shutt
    Jim and Pat Calhoun Cardiology Center, University of Connecticut Health Center, Farmington, Connecticut, USA
    Am J Physiol Cell Physiol 295:C692-700. 2008
    ..This increase in gain occurred regardless of whether cells were dialyzed with sodium-free solutions. Thus an increase in EC-coupling gain contributes importantly to positive inotropic effects of hypothermia in the heart...
  79. pmc Adenine nucleotide translocase 1 deficiency results in dilated cardiomyopathy with defects in myocardial mechanics, histopathological alterations, and activation of apoptosis
    Nupoor Narula
    Center for Mitochondrial and Molecular Medicine and Genetics MAMMAG, University of California, Irvine, California, USA
    JACC Cardiovasc Imaging 4:1-10. 2011
    ....
  80. ncbi Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance
    Mark F Berry
    Division of Cardiothoracic Surgery, Department of Physiology, University of Pennsylvania School of Medicine, A700 Richards Bldg, 3700 Hamilton Walk, Philadelphia, PA 19104 6085, USA
    Am J Physiol Heart Circ Physiol 290:H2196-203. 2006
    ..Improving scarred heart muscle compliance could be a functional benefit of cellular cardiomyoplasty...
  81. pmc Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?
    M Gautel
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 14:1952-60. 1995
    ..2 in humans, and is therefore in a region of physical linkage to subsets of familial hypertrophic cardiomyopathy (FHC). This makes cardiac MyBP-C a candidate gene for chromosome 11-associated FHC...
  82. ncbi Left ventricular myocardial deformation and mechanical dyssynchrony in children with normal ventricular shortening fraction after anthracycline therapy
    Yiu Fai Cheung
    Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Heart 96:1137-41. 2010
    ....
  83. ncbi Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene
    Kristin Brevik Andersson
    Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    J Mol Cell Cardiol 47:180-7. 2009
    ..Our data demonstrate that SR-independent Ca(2+) transport mechanisms temporarily can prevent major cardiac dysfunction despite a major reduction of SERCA2 in cardiomyocytes...
  84. ncbi Ventricular untwisting: a temporal link between left ventricular relaxation and suction
    Yuichi Notomi
    Department of Cardiovascular Medicine F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 294:H505-13. 2008
    ..Untwisting rate may be a useful marker of diastolic function or even serve as a therapeutic target for improving diastolic function...
  85. ncbi Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts
    Jun Ren
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY, USA
    Crit Care Med 36:2106-16. 2008
    ..This study was designed to examine the impact of glutathione depletion and the free radical scavenger, metallothionein (MT), on cardiac function...
  86. ncbi Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat
    Paul M L Janssen
    Institute of Molecular Cardiobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Heart Circ Physiol 282:H499-507. 2002
    ..We conclude that temperature independently affects contraction and relaxation, and cross-bridge cycling kinetics become rate limiting for cardiac relaxation under experimental conditions closest to those in vivo...
  87. ncbi Multiple defects in intracellular calcium cycling in whole failing rat heart
    J Andrew Wasserstrom
    Departments of Medicine and Molecular Pharmacology and Biological Chemistry and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Circ Heart Fail 2:223-32. 2009
    ..The goal of this study was to measure the defects in intracellular Ca(2+) cycling in left ventricular epicardial myocytes of the whole heart in an animal model of congestive heart failure (CHF)...
  88. ncbi Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias
    Martyn P Nash
    Bioengineering Institute and Department of Engineering Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Prog Biophys Mol Biol 85:501-22. 2004
    ..We show that tissue mechanics significantly contributes to the dynamics of electrical propagation, and that a coupled electromechanical approach should be pursued in future electrophysiological modelling studies...
  89. ncbi Impaired contractile function and mitochondrial respiratory capacity in response to oxygen deprivation in a rat model of pre-diabetes
    M F Essop
    Department of Physiological Sciences, Stellenbosch University, South Africa
    Acta Physiol (Oxf) 197:289-96. 2009
    ..This study tested the hypothesis that mitochondrial respiratory capacity of the pre-diabetic heart is decreased leading to impaired contractile function and tolerance to ischaemia/reperfusion...
  90. ncbi Magnetic resonance tissue phase mapping of myocardial motion: new insight in age and gender
    Daniela Föll
    Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstrasse 55, Freiburg, Germany
    Circ Cardiovasc Imaging 3:54-64. 2010
    ..Magnetic resonance phase-contrast imaging (tissue phase mapping) enabling the analysis of segmental, 3-directional myocardial velocities with high temporal resolution (13.8 ms) was used to assess left ventricular motion...
  91. pmc Myocardial tagging by cardiovascular magnetic resonance: evolution of techniques--pulse sequences, analysis algorithms, and applications
    El Sayed H Ibrahim
    Department of Radiology, University of Florida, Jacksonville, USA
    J Cardiovasc Magn Reson 13:36. 2011
    ..Finally, the current article includes a plethora of ideas and techniques with over 300 references that motivate the reader to think about the future of CMR tagging...
  92. pmc Protein kinase Cα as a heart failure therapeutic target
    Qinghang Liu
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Mol Cell Cardiol 51:474-8. 2011
    ..This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."..
  93. pmc Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data
    Sabine Fredersdorf
    Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, Regensburg, Germany
    Cardiovasc Diabetol 11:57. 2012
    ..Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins)...
  94. pmc Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease
    Farah Sheikh
    Department of Medicine, UCSD, La Jolla, California 92093 0613C, USA
    J Clin Invest 122:1209-21. 2012
    ..Thus, there is a direct and early role for Mlc2 phosphorylation in regulating actin-myosin interactions in striated muscle contraction, and dephosphorylation of Mlc2 or loss of these mechanisms can play a critical role in heart failure...
  95. pmc Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity
    Joshua D Lovelock
    Section of Cardiology, University of Illinois at Chicago, 60612, USA
    Circ Res 110:841-50. 2012
    ..Oxidative stress has been shown to increase late inward sodium current (I(Na)), reducing the net cytosolic Ca(2+) efflux...
  96. ncbi Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships
    D A Kass
    Johns Hopkins Medical Institutions, Department of Medicine, Baltimore, MD
    Circulation 76:1422-36. 1987
    ..Any advantage of the ESPVR will derive not from the magnitude of its response to inotropic change, which is smaller than most other indexes, but from its relative insensitivity to load alteration over a wider range of load...
  97. ncbi A computational study of the interaction between coronary blood flow and myocardial mechanics
    Nicolas P Smith
    Bioengineering Institute, University of Auckland, Auckland 1020, New Zealand
    Physiol Meas 25:863-77. 2004
    ..to cardiac mechanics, is verified with experimental data and used to investigate the mechanisms by which myocardial contraction inhibits coronary blood flow...
  98. pmc Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy
    Julio C B Ferreira
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 51:980-7. 2011
    ....
  99. ncbi Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function
    Robert S Haworth
    Cardiovascular Division, King s College London, London, UK
    Circ Res 95:1091-9. 2004
    ..Our data suggest that PKD is a novel mediator of cTnI phosphorylation at the PKA sites and may contribute to the regulation of myofilament function...
  100. ncbi Novel MRI method to detect altered left ventricular ejection and filling patterns in rodent models of disease
    Daniel J Stuckey
    Department of Physiology, Cardiac Metabolism Research Group, Anatomy and Genetics, University of Oxford, Oxford, UK
    Magn Reson Med 60:582-7. 2008
    ..In conclusion, the HTR MRI technique revealed changes in function that were below the limits of detection of standard cine-MRI...
  101. pmc Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis
    Bradley K McConnell
    Department of Physiology and Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 284:1583-92. 2009
    ..Increased cTnI N-terminal truncation was also observed in Ht31-expressing hearts versus controls. Increased cTnI-ND may help compensate for reduced PKA phosphorylation as occurs in heart failure...

Research Grants63

  1. Regulation of Ca-signaling in Myofilaments by Troponin C
    Ronglih Liao; Fiscal Year: 2006
    ..These missense mutations are located within the Ca2+-binding domain that regulates myocardial contraction, and result in decreased myofilament Ca2+ responsiveness...
  2. Phenotypic characterization of nitric oxide regulation of cardiac function by MRI
    Xin Yu; Fiscal Year: 2013
    ..The mechanistic elucidation of the effects of nNOS on myocardial contraction and disease progression will allow nNOS to be a therapeutic target in cardiovascular diseases...
  3. Onset and Progression of Contractile Dysfunction in Hypertrophic Cardiomyopathy
    PETER P CHEN; Fiscal Year: 2012
    ..are not well established and require further investigation into the functional roles of cMyBP-C in myocardial contraction and the resulting deficits that occur following the disruption of cMyBP-C expression...
  4. Functional Characterization of synaptic calcium/calmodulin kinase II (CaMKII) acc
    Jacqueline K Rose; Fiscal Year: 2010
    ..As CaMKII activation is involved in several physiological processes, ranging from myocardial contraction to synaptic plasticity, as well as neurological disorders like Alzheimer's, epilepsy and cell death ..
  5. Conduction System Remodeling After Myocardial Infarction
    TERRENCE XAVIER O'BRIEN; Fiscal Year: 2011
    ..and heart failure affect the conduction system and may lead to ventricular arrhythmias and/or inefficient myocardial contraction (i.e., dyssynchrony)...
  6. My-BP-C Modulation of Cardiac Contraction
    Richard L Moss; Fiscal Year: 2013
    ..to elucidate mechanisms by which Ca2+, intermolecular cooperativity, and protein phosphorylations regulate myocardial contraction in health and disease...
  7. A new post-translational modification, citrullination, changes in heart failure
    Jennifer E Van Eyk; Fiscal Year: 2013
    ..results, we hypothesize that citrullination plays a role in the pathogenesis of HF, particularly affecting myocardial contraction. Furthermore, we hypothesize that citrullination is exacerbated in HF especially when there is an ..
  8. Role of Myosin Binding Protein-C in the Regulation of Myocardial Contraction
    Samantha P Harris; Fiscal Year: 2013
    ..is to understand the function of cardiac myosin binding protein-C (cMyBP-C) in the regulation of myocardial contraction. Mutations in cMyBP-C cause hypertrophic cardiomyopathy and heart failure in millions of people worldwide ..
  9. Allosteric Regulation of Myocardial Contraction
    JOHN MARSHALL ROBINSON; Fiscal Year: 2013
    ..The goal of this project is to establish mechanism of cooperative myofilament activation (Aim 1) and to establish the mechanism of altered myofilament sensitivity to Ca2+ (Aim II). ..
  10. Detection of Left Ventricular Dyssynchrony by Cross-Correlation Analysis
    John Oshinski; Fiscal Year: 2009
    ..Project Summary In thirty percent of patients with severe, drug-refractory heart failure, regional timing of myocardial contraction and relaxation is dyssynchronous...
  11. ULTRASONIC TISSUE CHARACTERIZATION ADAPTATIONS
    Kiran Sagar; Fiscal Year: 1990
    ..Microscope, and indirectly by testing the hypothesis that since cardiac cycle variability is dependent on myocardial contraction, it will also vary with changes in heart rate, preload, afterload, and inotropic state; 2) role of ..
  12. REGULATION OF CARDIAC ENERGY PRODUCING ENZYMES
    Arnold Strauss; Fiscal Year: 2001
    ..in mitochondria is transferred as CP to the myofibrillar apparatus and serves as the source of energy for myocardial contraction. Our specific aims are to (1) delineate tissue-specific regulatory sequences in the human MtCK genes by ..
  13. RADIOGRAPHIC VENTRICULOMETRY FOR CORONARY HEART DISEASE
    Kurt Amplatz; Fiscal Year: 1980
    ..is to improve the radiological diagnosis of ischemic heart disease by using new information from regional myocardial contraction analysis...
  14. Myosin Isoforms in Relation to Function in Human Heart
    Richard L Moss; Fiscal Year: 2010
    ..These studies promise'to provide new insights into the mechanisms by which myocardial contraction varies in health and disease, and results should identify potential molecular targets for therapeutic ..
  15. High Throughput Profiling of Plant Extracts Using Engineered Heart Tissues
    Tetsuro Wakatsuki; Fiscal Year: 2006
    ..We will identify "hit" extracts by their ability to alter 2 important parameters of myocardial contraction measured by our tissue assay system...
  16. ALCOHOL EFFECTS ON HEART FUNCTION--GENDER DIFFERENCES
    Mariann Piano; Fiscal Year: 2000
    ..determine if the development of alcohol-induced cardiomyopathy is associated with corresponding changes in myocardial contraction and activation of specific hemodynamic and neuroendocrine mechanisms in male and female rats...
  17. Integrated Myocardial Ischemia Assessment with MRI
    John Pauly; Fiscal Year: 2006
    ..While raw image acquisition speed has improved significantly, the goal of assessing myocardial contraction and perfusion volumetrically during an induced 60-90 second time window of true ischemia is far from being ..
  18. HIGH RESOLUTION MRI OF MYOCARDIAL DEFORMATION
    Henry Halperin; Fiscal Year: 2001
    ..Our preliminary data show that we can resolve a "pulse" of myocardial contraction that emanates from a pacing site, travels around the left ventricle, and converges on the opposite wall of ..
  19. Role of Small GTPases in Muscarinic Receptor Trafficking
    ALFRED MERRILL; Fiscal Year: 2005
    ..effects of adrenaline to either stimulate myopulmonary contraction or to decrease the rate and force of myocardial contraction. Limiting m2R signaling is critical for normal cardiac function since persistent activation (e.g...
  20. IONIC CURRENTS AND AUTONOMIC REGULATION IN HEART FAILURE
    Atsuko Yatani; Fiscal Year: 2002
    ..A number of Ca/2+ handling systems involved in myocardial contraction and the cellular basis for the defect in heart failure is not completely understood...
  21. NMR STUDIES OF MYOCARDIAL METABOLISM IN VIVO
    RAPHAEL ZAHLER; Fiscal Year: 1990
    When coronary blood flow is suddenly interrupted, myocardial contraction in the ischemic area becomes depressed within seconds. The biochemical mechanism of this ischemic dysfunction is not well understood...
  22. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  23. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  24. Cardiac Contraction-Relaxation Coupling
    PAULUS JANSSEN; Fiscal Year: 2008
    ....
  25. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  26. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002
    ..Ultimately, our research will determine the role of these gene products in mediating the effect of nicotine in humans. ..
  27. NOS1/NOS3 Functional Effects on Cardiac Myocyte Function
    Mark T Ziolo; Fiscal Year: 2010
    ..The relevance of this proposal to public health is that these results may improve the treatment of heart disease by potentially identifying new targets for drug development. ..
  28. A Validated Micro-Structural Mechanical Model of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ....
  29. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    HECTOR MOBINE; Fiscal Year: 2008
    ..The findings may not only afford further appreciation of the pathophysiology and etiology of peripartum cardiomyopathy but also of general mechanisms in disease progression. [unreadable] [unreadable] [unreadable]..
  30. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..The long-term goal of this research is to develop optimal therapies to restore the oxidative balance in CAD. ..
  31. Pak1 Regulation of Cardiac Protein Phosphorylation
    Katherine Sheehan; Fiscal Year: 2005
    ..Together these data will provide evidence for a novel pathway of activation of PP2A and a role for concomitant regulation of contractile and intracellular Ca2+ handling. ..
  32. SR Ca2+ ATPase, a determinant of cardiac contractility
    Muthu Periasamy; Fiscal Year: 2007
    ..As such, these studies are likely to suggest novel clinical strategies that might be pursued for the management of chronic heart failure in humans. [unreadable] [unreadable]..
  33. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  34. Functional Coupling between Ito and ICa in Cardiomyocytes
    Yanggan Wang; Fiscal Year: 2010
    ..The proposed study implicates a cell membrane potassium channel (Ito) in regulating the cellular calcium influx channel (ICa) function, which may decipher a new mechanism for this morbid disease. ..
  35. VOLATILE ANESTHETICS IN PRESSURE OVERLOAD HYPERTROPHY
    James Hannon; Fiscal Year: 2002
    ....
  36. MAGNETIC RESONANCE CORONARY ANGIOGRAPHY
    John Oshinski; Fiscal Year: 2001
    ....
  37. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2005
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  38. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  39. ADENOSINE A1 AND A2 RECEPTORS IN THE MYOCARDIUM
    James Dobson; Fiscal Year: 2004
    ..Additionally, the findings should significantly contribute to our basic knowledge of the molecular mechanisms of G protein coupled receptor cross-regulation in the heart. ..
  40. Gordon Research Conference:Cardiac Regulatory Mechanisms
    R Solaro; Fiscal Year: 2002
    ..Much of the time of the meeting is devoted to debates and discussion. Presentations of late breaking science from young investigator will be added from the posters submitted to the meeting. ..
  41. Virtual Electrode Polarization Hypothesis of Defibrillation
    Igor R Efimov; Fiscal Year: 2010
    ..This energy reduction will improve the life time and reliability of implantable devices and will reduce the side-effects of defibrillation. It is also likely to reduce the number of ICD malfunctions and reimplantations. ..
  42. REGULATION OF EXPRESSION OF NO SYNTHASE
    Louis Ignarro; Fiscal Year: 2002
    ..The proposed research represents a continuing long-term effort to elucidate the biological factors influencing the vascular and related actions of NO in health and disease. ..
  43. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  44. QUANTITATIVE CARDIAC PHYSIOLOGY IN CLINICAL CARDIOLOGY
    Sandor Kovacs; Fiscal Year: 2004
    ..abstract_text> ..
  45. Cardiac Teratogenicity of Lithium
    Kersti Linask; Fiscal Year: 2004
    ..Until the safety of lithium is conclusively proven, one must assume teratogenic potential and harm to the fetus. ..
  46. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2005
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
  47. Mechnaisms of Late Sodium Current in Failing Heart
    Albertas Undrovinas; Fiscal Year: 2006
    ..Knowledge derived from the present proposal may reveal novel targets for the treatment of life-threatening arrhythmias associated with chronic HF. ..
  48. HIV/HCV Co-infection: HAART and CVD Pathophysiology
    Barry Hurwitz; Fiscal Year: 2006
    ..abstract_text> ..
  49. Peroxynitrate neutralizing agents for stroke therapy
    Csaba Szabo; Fiscal Year: 2003
    ....
  50. Cardiac KATP Channels in Health and Disease
    Andre Terzic; Fiscal Year: 2007
    ..Thus, this proposal will provide an integrated understanding of cardiac KATP channels in metabolic signal decoding, stress adaptation, and their impact for clinical medicine. ..
  51. Insulin resistance and cardiac dysfunction in obesity
    EVAN ABEL; Fiscal Year: 2007
    ..These studies will provide a detailed and comprehensive analysis of the role that abnormal myocardial insulin signaling plays in the pathogenesis of cardiac dysfunction in obesity. ..
  52. PROPERTIES OF INWARD RECTIFIER K CHANNELS
    James Weiss; Fiscal Year: 2007
    ..abstract_text> ..
  53. Daily genistein injections stimulate intestinal secretion: How?
    Layla Al Nakkash; Fiscal Year: 2007
    ..Furthermore, we aim to identify the suitability of genistein as a potential therapeutic for the most common lethal genetic disease in Caucasians, cystic fibrosis (CF). [unreadable] [unreadable] [unreadable]..
  54. Testosterone in TNFR1 Signaling During Acute Myocardial Injury
    Meijing Wang; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  55. CAUSE AND CONSEQUENCE OF TNF OVEREXPRESSION IN THE HEART
    Douglas Mann; Fiscal Year: 2007
    ..Taken together, these studies will provide definitive new information with respect to the role of TGF-beta mediated Smad dependent signaling and myocardial fibrosis in an experimental model of sustained inflammation. ..
  56. CARDIAC TISSUE STRUCTURE IN THE DEFIBRILLATION PROCESS
    Natalia Trayanova; Fiscal Year: 2008
    ..The proposed research is expected to guide experimental design and interpretation of experimental findings, and ultimately, to lead to rational rather than trial-and-error advancements in defibrillation procedure. ..
  57. ULTRASOUND-INDUCED DRUG DELIVERY THROUGH THE BLOOD-BRAIN BARRIER
    Elisa Konofagou; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  58. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2004
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..