ventricular pressure

Summary

Summary: The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.

Top Publications

  1. ncbi Effects of a novel ultrasound contrast agent with long persistence on right ventricular pressure: Comparison with SonoVue
    Ping Liu
    Department of Ultrasound, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China
    Ultrasonics 51:210-4. 2011
  2. ncbi Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model
    Yulin Liao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circ Res 93:759-66. 2003
  3. ncbi Role of radial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overload
    Kaoru Dohi
    Mie University Graduate School of Medicine, Tsu, Japan
    Am J Cardiol 101:1206-12. 2008
  4. ncbi Aromatase deficiency confers paradoxical postischemic cardioprotection
    James R Bell
    Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Victoria 3010, Australia
    Endocrinology 152:4937-47. 2011
  5. pmc Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats
    Anne M Deschamps
    National Institutes of Health, National Heart, Lung, and Blood Institute, Translational Medicine Branch, Laboratory of Cardiac Physiology, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 297:H1806-13. 2009
  6. ncbi Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
  7. pmc Increased brain and atrial natriuretic peptides in patients with chronic right ventricular pressure overload: correlation between plasma neurohormones and right ventricular dysfunction
    I I Tulevski
    Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1100 DD Amsterdam, Netherlands
    Heart 86:27-30. 2001
  8. ncbi Gender differences in molecular remodeling in pressure overload hypertrophy
    E O Weinberg
    Charles A Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 34:264-73. 1999
  9. pmc Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females
    Yvonne Dempsie
    College of Medical, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Respir Res 12:159. 2011
  10. ncbi Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers
    Daniel Burkhoff
    Division of Cardiology, Dept of Medicine, Columbia Univ, Black Bldg 812, 650 West 168th St, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 289:H501-12. 2005

Detail Information

Publications223 found, 100 shown here

  1. ncbi Effects of a novel ultrasound contrast agent with long persistence on right ventricular pressure: Comparison with SonoVue
    Ping Liu
    Department of Ultrasound, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China
    Ultrasonics 51:210-4. 2011
    ..of infusion of a self-made ultrasound contrast agent with long persistence (named ZHIFUXIAN) on rat right ventricular pressure and made a preliminary evaluation on the relative safety of the novel microbubbles...
  2. ncbi Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model
    Yulin Liao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circ Res 93:759-66. 2003
    ..These results indicate that the stimulation of adenosine receptors attenuates both the cardiac hypertrophy and myocardial dysfunction via adenosine A1 receptor-mediated mechanisms...
  3. ncbi Role of radial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overload
    Kaoru Dohi
    Mie University Graduate School of Medicine, Tsu, Japan
    Am J Cardiol 101:1206-12. 2008
    ....
  4. ncbi Aromatase deficiency confers paradoxical postischemic cardioprotection
    James R Bell
    Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Victoria 3010, Australia
    Endocrinology 152:4937-47. 2011
    ..Left ventricular developed pressures were similar in aerobic perfusion, but the maximal rate of rise of ventricular pressure was modestly reduced in ArKO hearts (3725 ± 144 vs. 4272 ± 154 mm Hg/sec, P < 0.05)...
  5. pmc Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats
    Anne M Deschamps
    National Institutes of Health, National Heart, Lung, and Blood Institute, Translational Medicine Branch, Laboratory of Cardiac Physiology, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 297:H1806-13. 2009
    ..Taken together, the data show that G-1 activation of GPER improves functional recovery and reduces infarct size in isolated rat hearts following I/R through a PI3K-dependent, gender-independent mechanism...
  6. ncbi Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
    ..It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven...
  7. pmc Increased brain and atrial natriuretic peptides in patients with chronic right ventricular pressure overload: correlation between plasma neurohormones and right ventricular dysfunction
    I I Tulevski
    Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1100 DD Amsterdam, Netherlands
    Heart 86:27-30. 2001
    ..ANP) concentrations were measured in 21 asymptomatic or minimally symptomatic patients with chronic right ventricular pressure overload caused by congenital heart disease, and in seven healthy volunteers...
  8. ncbi Gender differences in molecular remodeling in pressure overload hypertrophy
    E O Weinberg
    Charles A Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 34:264-73. 1999
    ..The objective of this study was to examine gender differences in left ventricular (LV) function and expression of cardiac genes in response to LV pressure overload due to ascending aortic stenosis in rats...
  9. pmc Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females
    Yvonne Dempsie
    College of Medical, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Respir Res 12:159. 2011
    ..We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH...
  10. ncbi Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers
    Daniel Burkhoff
    Division of Cardiology, Dept of Medicine, Columbia Univ, Black Bldg 812, 650 West 168th St, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 289:H501-12. 2005
    ..and end-diastolic pressure-volume relationships derived from measurements of instantaneous left ventricular pressure-volume loops emerged in the 1970s as a comprehensive approach for this purpose...
  11. ncbi The E/e filling index and right ventricular pressure in relation to applied international Doppler recommendations of left ventricular filling assessment
    Cecilia Wallentin Guron
    Department of Clinical Physiology, Sahlgrenska University Hospital, SE 416 85 Goteborg, Sweden
    Eur J Echocardiogr 6:419-28. 2005
    ..An elevated LVFP implies an elevated right ventricular pressure (RVp)...
  12. ncbi Left ventricular pressure and volume unloading during pulsatile versus nonpulsatile left ventricular assist device support
    Stefan Klotz
    Department of Thoracic and Cardiovascular Surgery, University Hospital, Muenster, Germany
    Ann Thorac Surg 77:143-9; discussion 149-50. 2004
    ..We compared LV unloading and mortality between different types of LVAD support (pulsatile versus nonpulsatile)...
  13. ncbi Left ventricular pressure and volume data acquisition and analysis using LabVIEW
    S C Cassidy
    Department of Pediatrics, Ohio State University, Columbus, USA
    Comput Biol Med 27:141-9. 1997
    To automate analysis of left ventricular pressure-volume data, we used LabVIEW to create applications that digitize and display data recorded from conductance and manometric catheters...
  14. pmc Acute right ventricular pressure overload compromises left ventricular function by altering septal strain and rotation
    Jason Chua
    Department of Anesthesiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California
    J Appl Physiol (1985) 115:186-93. 2013
    ..05). Our results suggest that acute RVPO impairs LV performance by primarily altering septal strain and apical rotation. ..
  15. ncbi Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution
    Yuji Maruyama
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute, King s College London, Guy s and St Thomas Hospital, London, UK
    Interact Cardiovasc Thorac Surg 7:745-9. 2008
    ..Magnesium-based cardioplegia may be a useful alternative to hyperkalaemic cardioplegia under certain specific conditions...
  16. ncbi Dissociation of pulmonary vascular remodeling and right ventricular pressure in tissue angiotensin-converting enzyme-deficient mice under conditions of chronic alveolar hypoxia
    R J van Suylen
    Department of Pathology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 163:1241-5. 2001
    ..Also, pulmonary vascular remodeling occurs in hypoxic tissue ACE-deficient mice, albeit to a lower level than in mice that do have an intact ACE gene...
  17. pmc Left ventricular pressure-volume loops during mechanical alternans in a patient with dilated cardiomyopathy
    T Kashimura
    Heart 93:151. 2007
  18. ncbi Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function
    Vincent J A Bourgonje
    Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
    Circ Arrhythm Electrophysiol 6:371-9. 2013
    ....
  19. ncbi The efficacy and tolerability of azilsartan in obese insulin-resistant mice with left ventricular pressure overload
    A K M Tarikuz Zaman
    Cardiovascular Research Institute and Department of Medicine, University of Vermont College of Medicine, Colchester, VT
    J Cardiovasc Pharmacol 62:381-7. 2013
    ..Thus, azilsartan exerted favorable biological effects on the hearts of obese insulin-resistant mice subjected to LV pressure overload consistent with its potential utility in patients with analogous conditions...
  20. pmc Combining tissue Doppler echocardiography and B-type natriuretic peptide in the evaluation of left ventricular filling pressures: review of the literature and clinical recommendations
    Hisham Dokainish
    Baylor College of Medicine, Houston, TX 77030, USA
    Can J Cardiol 23:983-9. 2007
    ..Taking into account the respective strengths and limitations of BNP and mitral E/Ea, algorithms combining them can be used to more accurately estimate LV filling pressures in patients presenting with dyspnea...
  21. pmc A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work
    Kristoffer Russell
    Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Eur Heart J 33:724-33. 2012
    ..In this study, we introduce a non-invasive method to measure LV pressure-strain loop area...
  22. ncbi Influence of clenbuterol treatment during six weeks of chronic right ventricular pressure overload as studied with pressure-volume analysis
    J K Hon
    Department of Cardiothoracic Surgery, National Heart and Lung Institute at Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 122:767-74. 2001
    ..We sought to determine the cardiac hypertrophic effects of clenbuterol on the thin-walled ventricles of large animals undergoing chronic pressure overload by means of pulmonary artery banding...
  23. ncbi Echocardiographic evidences of increased left ventricular pressure and atrial dilatation in patients with drug-resistant paroxystic atrial fibrillation and structurally normal heart
    D Cozma
    Institute of Cardiovascular Medicine, Timisoara, Romania
    Rom J Intern Med 42:129-36. 2004
    ..Global myocardial index (GMI) has been significantly related to left ventricular filling pressure. We hypothesized that GMI and echographic indicators of atrial dilatation were significantly different in pAF pts compared to normals...
  24. pmc Chronic endothelin-A receptor antagonism is as protective as angiotensin converting enzyme inhibition against cardiac dysfunction in diabetic rats
    G Wölkart
    Department of Pharmacology and Toxicology, University of Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Br J Pharmacol 151:1187-97. 2007
    ..We compared the cardioprotective effects of an endothelin-A receptor blocker (ET(A)-RB) with those of an angiotensin-converting enzyme inhibitor (ACE-I) in rats with streptozotocin (STZ)-induced diabetes...
  25. ncbi Severe, short-term food restriction improves cardiac function following ischemia/reperfusion in perfused rat hearts
    Tadashi Yamagishi
    Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Heart Vessels 25:417-25. 2010
    ....
  26. ncbi Left ventricular pressure, contractility and dP/dt(max) in nonclinical drug safety assessment studies
    R Dustan Sarazan
    Data Sciences International, 119 14th St NW, Suite 100 St Paul, MN 55112, USA
    J Pharmacol Toxicol Methods 66:71-8. 2012
    ..Left ventricular dP/dt is the first derivative of left ventricular pressure, which is computed by software algorithms by using calculus...
  27. ncbi Mechanisms of abnormal systolic motion of the interventricular septum during left bundle-branch block
    Ola Gjesdal
    Institute for Surgical Research and Department of Cardiology, Oslo University Hospital, Rikshospitalet, and University of Oslo, Oslo, Norway
    Circ Cardiovasc Imaging 4:264-73. 2011
    ..If considered active, however, the leftward motion reflects onset of septal activation and should be included. We therefore investigated if the motion was a passive response to pressure changes or caused by active contraction...
  28. ncbi Colour M-mode velocity propagation: a glance at intra-ventricular pressure gradients and early diastolic ventricular performance
    Bart W L De Boeck
    Division of Cardiology, Heart Lung Centre, University Hospital Utrecht, Heidelberglaan 100, Postbus 85500, 3508 GA, Utrecht, The Netherlands
    Eur J Heart Fail 7:19-28. 2005
    ..These factors not only are prime determinants of left ventricular pressure decay during isovolumic relaxation and immediately after mitral valve opening; they also instigate the ..
  29. ncbi Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Homburg Saar D 66421, Germany
    Cardiovasc Res 87:485-93. 2010
    ..The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology...
  30. ncbi Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage
    Jun Te Hsu
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan
    Am J Physiol Heart Circ Physiol 292:H2982-7. 2007
    ..These results suggest that the salutary effect of E(2) on cardiac function after trauma-hemorrhage is in part mediated via upregulation of p38 MAPK and subsequent phosphorylation of HSP27 and alpha(B)-crystallin...
  31. ncbi Cardioprotection through a PKC-dependent decrease in myofilament ATPase
    W Glen Pyle
    Department of Physiology, University of Tennessee Memphis, 894 Union Avenue, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 285:H1220-8. 2003
    ..Thus we propose PKC-epsilon activation and translocation to the myofilaments causes a decrease in actomyosin ATPase, which contributes to the kappa-opioid receptor-dependent cardioprotective mechanism...
  32. ncbi Protective role of angiopoietin-1 in experimental pulmonary hypertension
    Yidan D Zhao
    Terrence Donnelly Research Laboratories, Division of Cardiology, St Michael s Hospital and University of Toronto, Ontario, Canada
    Circ Res 92:984-91. 2003
    ..Thus, cell-based gene transfer with Ang-1 improved survival and pulmonary hemodynamics in experimental pulmonary hypertension by a mechanism involving the inhibition of apoptosis and protection of the pulmonary microvasculature...
  33. ncbi Global diastolic strain rate for the assessment of left ventricular relaxation and filling pressures
    Jianwen Wang
    Department of Cardiology and Methodist DeBakey Heart Center, The Methodist Hospital, Houston, Tex 77030, USA
    Circulation 115:1376-83. 2007
    ..Mitral early diastolic velocity (E)/SR ratio during the isovolumetric relaxation (IVR) period can be used to estimate LV filling pressures...
  34. ncbi Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens
    Jason D Gardner
    Department of Cell and Developmental Bioloogy and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 294:H198-204. 2008
    ....
  35. ncbi Postsystolic shortening in ischemic myocardium: active contraction or passive recoil?
    Helge Skulstad
    Institute for Surgical Research and Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    Circulation 106:718-24. 2002
    ..Our objectives were to determine if postsystolic shortening represents active fiber shortening or passive recoil and if postsystolic shortening may be quantified by strain Doppler echocardiography (SDE)...
  36. ncbi Effect of high salt intake on local renin-angiotensin system and ventricular dysfunction following myocardial infarction in rats
    Micheline M de Resende
    Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, Espirito Santo, Brazil
    Clin Exp Pharmacol Physiol 34:274-9. 2007
    ..This suggests that local activation of the RAS in the heart, which was not suppressed by salt overload, exerts a predominant role for local adaptations of the heart after MI...
  37. ncbi Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction
    Aleksandr Rovner
    Department of Cardiology, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 285:H2492-9. 2003
    ..6, P < 0.01). Reduction of LVOT obstruction after ESR is associated with an improvement in diastolic suction force. Noninvasive measurements of IVPG may be used as an indicator of diastolic function improvement in HOCM...
  38. ncbi Ratio of left atrial to left ventricular size: an anatomical marker of the diastolic left ventricular pressure-volume relationship
    Daniel M Spevack
    Department of Medicine, Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Echocardiography 25:366-73. 2008
    ..We thus investigated the association of this novel marker with exposures known to induce diastolic dysfunction and with clinical evidence of diastolic dysfunction...
  39. ncbi Continuous ambulatory monitoring of absolute right ventricular pressure and mixed venous oxygen saturation in patients with heart failure using an implantable haemodynamic monitor: results of a 1 year multicentre feasibility study
    A Ohlsson
    Karolinska Hospital, Stockholm, Sweden
    Eur Heart J 22:942-54. 2001
    ..The IHM-1, using right ventricular pressures and SvO(2), with improved performance, might be useful in the study of pathophysiological mechanisms and treatment interventions in heart failure...
  40. ncbi Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats
    Miriam P Bal
    Department of Cardiology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    J Appl Physiol (1985) 104:446-50. 2008
    ..If applicable to humans, cardiac screening of a relatively large patient group to enable secondary prevention may be indicated...
  41. pmc Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropism
    Li Jianhui
    Dept of Intensive Care Medicine, Univ Hospital Center and Faculty of Biology and Medicine, CHUV BH 08 621, 1011 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 299:H492-501. 2010
    ..Therefore, the alterations of cardiac function induced by LPS are entirely due to altered loading conditions, but not to reduced contractility, which may instead be slightly increased...
  42. ncbi Optimal noninvasive assessment of left ventricular filling pressures: a comparison of tissue Doppler echocardiography and B-type natriuretic peptide in patients with pulmonary artery catheters
    Hisham Dokainish
    Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:2432-9. 2004
    ....
  43. pmc Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure
    Pal Pacher
    National Institute on Alcohol Abuse and Alcoholism, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892 8115, USA
    Am J Physiol Heart Circ Physiol 287:H2132-7. 2004
    ..dP/dt), and its relation to end-diastolic volume (+dP/dt-EDV) as well as the time constant of left ventricular pressure decay, as an index of relaxation...
  44. ncbi Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography
    Jae K Oh
    Mayo Clinic College of Medicine, Echocardiography Laboratory, Division of Cardiology, Rochester, Minnesota 55905 0001, USA
    J Am Coll Cardiol 47:500-6. 2006
    ..Early identification of diastolic dysfunction in asymptomatic patients by the use of echocardiography may provide an opportunity to manage the underlying etiology to prevent progression to diastolic heart failure...
  45. ncbi Computerized left ventricular pressure-volume relationships (pV-loops) using disposable angiographic tip transducer pigtail catheters
    U Raff
    University of Colorado Health Sciences Center, Department of Medicine, Denver, USA
    Int J Card Imaging 16:13-21. 2000
    Left ventricular pressure-volume relationships expressed as pV loops could yield important hemodynamic information in the cardiac catheterization laboratory...
  46. ncbi Improved ECG detection of presence and severity of right ventricular pressure load validated with cardiac magnetic resonance imaging
    Ivo R Henkens
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H2150-7. 2008
    ..The use of the ventricular gradient allows ECG detection of even mildly increased RV pressure load...
  47. pmc Interatrial shunt for chronic pulmonary hypertension: differential impact of low-flow vs. high-flow shunting
    Andreas Zierer
    Division of Cardiothoracic Surgery, Washington Univ School of Medicine, 3108 Queeny Tower, 1 Barnes Jewish Plaza, St Louis, Missouri 63110 1013, USA
    Am J Physiol Heart Circ Physiol 296:H639-44. 2009
    ..With progressive shunting, right ventricular pressure fell from 72 +/- 19 mmHg (CPH) to 54 +/- 17 mmHg (Low-Flow) and 47 +/- 17 mmHg (High-Flow) (P < 0.001)...
  48. ncbi Effect of glucose and fatty acid availability on neonatal and adult heart contractility
    Verónica Guarner
    Department of Physiology, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico
    Biol Neonate 82:39-45. 2002
    ..12 mM) increased the differential ventricular pressure (DVP), while higher doses of fatty acids (from 0.3 to 1.5 mM) decreased it...
  49. ncbi Doppler estimation of left ventricular filling pressures in patients with mitral valve disease
    Abhinav Diwan
    Section of Cardiology, University of Cincinnati, Cincinnati, Ohio, USA
    Circulation 111:3281-9. 2005
    ..We therefore undertook this study to test its usefulness in a patient population...
  50. ncbi Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases
    Sundaravadivel Balasubramanian
    Cardiology Division of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, SC 29425 2221, USA
    J Mol Cell Cardiol 41:669-79. 2006
    ..Analysis using a feline right ventricular pressure overload (RVPO) model revealed a robust and transient increase in ubiquitination of proteins present in the ..
  51. ncbi Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure
    Gerard P Aurigemma
    Department of Medicine, Division of Cardiology, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am Heart J 148:E12. 2004
    ..The purpose of this study was to compare invasive with noninvasive indices of diastolic function in a well-defined group of patients with diastolic dysfunction and a history of diastolic heart failure...
  52. pmc Sex-related changes in cardiac function following myocardial infarction in mice
    Krystyna M Shioura
    University of Illinois at Chicago, Department of Medicine Section of Cardiology, 840 S Wood St, M C 715 Chicago, IL 60612, USA
    Am J Physiol Regul Integr Comp Physiol 295:R528-34. 2008
    ..However, compensatory hypertrophy in males appears to be undermined by a steady decline in contractility associated with decompensation to HF...
  53. ncbi Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat
    Marleen H M Hessel
    Dept of Cardiology, C5 P, Leiden Univ Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H2424-30. 2006
    ..The most pronounced response to MCT was an overload-dependent increase of RV end-systolic and end-diastolic volumes, even under nonfailing conditions...
  54. pmc Cardiac MR elastography: comparison with left ventricular pressure measurement
    Thomas Elgeti
    Department of Radiology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Cardiovasc Magn Reson 11:44. 2009
    To compare magnetic resonance elastography (MRE) with ventricular pressure changes in an animal model.
  55. ncbi A self-calibrating telemetry system for measurement of ventricular pressure-volume relations in conscious, freely moving rats
    Kazunori Uemura
    Dept of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1, Fujishirodai, Suita 565 8565, Japan
    Am J Physiol Heart Circ Physiol 287:H2906-13. 2004
    ..Using Bluetooth wireless technology, we developed an implantable telemetry system for measurement of the left ventricular pressure-volume relation in conscious, freely moving rats...
  56. ncbi Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures
    S F Nagueh
    Baylor College of Medicine and Department of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 30:1527-33. 1997
    ....
  57. ncbi Biventricular systolic function in young lambs subject to chronic systemic right ventricular pressure overload
    B P Leeuwenburgh
    Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 281:H2697-704. 2001
    ..We concluded that chronic RV pressure overload for 8 wk results in diminished pump function despite compensatory increased RV global contractile performance...
  58. ncbi Afterload induced changes in myocardial relaxation: a mechanism for diastolic dysfunction
    A F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Portugal
    Cardiovasc Res 43:344-53. 1999
    ..It is well known that high afterload slows myocardial relaxation. This contribution investigated to what extent afterload elevation could also affect LV filling pressures including end-diastolic LV pressure (LVP)...
  59. ncbi Usefulness of new diastolic strain and strain rate indexes for the estimation of left ventricular filling pressure
    Hisham Dokainish
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA
    Am J Cardiol 101:1504-9. 2008
    ..In patients with LV ejection fraction > or =50% or indeterminate E/Ea, both E/Ds and E/10DSr (a ratio based on global DSR) were better predictors of LV filling pressure than E/Ea...
  60. ncbi Relationship of maximum rate of pressure rise between aorta and left ventricle in pediatric patients. Implication for ventricular-vascular interaction with the potential for noninvasive determination of left ventricular contractility
    Satoshi Masutani
    Department of Pediatric Cardiology, International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan
    Circ J 73:1698-704. 2009
    The maximum rate of the ventricular pressure rise (dp/dt(max)) provides a reliable measure of ventricular contractility...
  61. pmc Chronic right ventricular pressure overload results in a hyperplastic rather than a hypertrophic myocardial response
    Boudewijn P J Leeuwenburgh
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Anat 212:286-94. 2008
    ..We hypothesized that chronic right ventricular pressure overload imposed on neonatal hearts initiates a hyperplastic response in the right ventricular myocardium...
  62. ncbi Regional myocardial work by strain Doppler echocardiography and LV pressure: a new method for quantifying myocardial function
    Stig Urheim
    Institute for Surgical Research and Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    Am J Physiol Heart Circ Physiol 288:H2375-80. 2005
    ..03 kJ/m3 (P < 0.05) by SDE and sonomicrometry, respectively. A RMWI can be estimated by SDE in combination with LV pressure. Furthermore, the orientation of the loop can be used to assess whether the segment is active or passive...
  63. ncbi Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload
    P S Douglas
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 32:1118-25. 1998
    ..To identify gender differences in left ventricular remodeling, hypertrophy, and function in response to pressure overload due to ascending aortic banding in rats...
  64. ncbi Maximum derivative of left ventricular pressure predicts cardiac mortality after cardiac resynchronization therapy
    Hirohiko Suzuki
    Department of Cardiology, Nagoya University, Japan
    Clin Cardiol 33:E18-23. 2010
    ..However, CRT in patients with advanced heart failure is not always accompanied by an improvement in survival rates. We investigated the association between hemodynamic studies and long-term prognosis after CRT...
  65. ncbi Validation of a novel noninvasive cardiac index of left ventricular contractility in patients
    Liang Zhong
    Department of Cardiology, National Heart Centre, University of New South Wales Asia, Singapore
    Am J Physiol Heart Circ Physiol 292:H2764-72. 2007
    ..In contrast to other measures of contractility, d sigma*/dt(max) can be assessed with noninvasive cardiac imaging and, thereby, should have more routine clinical applicability...
  66. ncbi Effect of pulmonary valve regurgitation on right ventricular function in patients with chronic right ventricular pressure overload
    Igor I Tulevski
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 92:113-6. 2003
  67. ncbi Left ventricular pressure-volume relations with transesophageal echocardiographic automated border detection: comparison with conductance-catheter technique
    J Gorcsan
    Division of Cardiology, University of Pittsburgh Medical Center, Pennsylvania 15213-2582, USA
    Am Heart J 131:544-52. 1996
    ..92 mm Hg/ml versus 2.70 +/- 1.15 mm Hg/ml and 6.63 +/- 1.66 mm Hg/ml versus 3.20 +/- 1.37 mm Hg/ml (p<0.05), respectively. However, the direction and relative magnitude of changes in elastance with inotropic modulation were similar...
  68. ncbi Postextrasystolic left ventricular isovolumic pressure decay is not monoexponential
    M Courtois
    Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Cardiovasc Res 35:206-16. 1997
    ....
  69. ncbi Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension
    Patricia O Reger
    Department of Kinesiology, Temple Univ, 122 Pearson Hall, 1800 North Broad St, Philadelphia, PA 19122, USA
    J Appl Physiol 100:541-7. 2006
    ....
  70. ncbi Commentary on Viewpoint: Is left ventricular volume during diastasis the real equilibrium volume, and what is its relationship to diastolic suction?
    Mustafa Yildiz
    J Appl Physiol 105:1018; author reply 1019. 2008
  71. ncbi Commentary on Viewpoint: Is left ventricular volume during diastasis the real equilibrium volume, and what is the relationship to diastolic suction?
    Carl J Ade
    J Appl Physiol 105:1017; author reply 1019. 2008
  72. ncbi Computerized acoustic cardiographic electromechanical activation time correlates with invasive and echocardiographic parameters of left ventricular contractility
    Stilianos Efstratiadis
    Division of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah 84132 2401, USA
    J Card Fail 14:577-82. 2008
    ..We assessed the correlation between systolic dysfunction and EMAT calculated using computerized acoustic cardiography...
  73. ncbi Is diastasis really a phase of hemodynamic stasis?
    Partho P Sengupta
    J Appl Physiol 105:1016; author reply 1019. 2008
  74. ncbi Cardiac function and modulation of sarcomeric function by length
    Laurin M Hanft
    Department of Medical Pharmacology and Physiology, MA 415, Medical Sciences Building, School of Medicine, University of Missouri, Columbia, MO 65212, USA
    Cardiovasc Res 77:627-36. 2008
    ..The balance of these two properties seems to determine systolic haemodynamics, and how this balance is modulated by sarcomere length, in part, underlies the Frank-Starling relationship...
  75. ncbi Does left ventricular suction exist?
    Theo Arts
    J Appl Physiol 105:1015-6; author reply 1019. 2008
  76. ncbi Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levels
    Kazuki Nakajima
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu 514 0823, Japan
    Int J Cardiol 104:332-7. 2005
    ..Micromanometers and conductance catheters were used to obtain relatively load-insensitive left ventricular pressure-volume analysis in order to compare the myocardial and load-altering actions of ANP in 20 patients with low ..
  77. ncbi Tachycardia during the valsalva maneuver: a sign of normal diastolic filling pressures
    Calin V Maniu
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Am Soc Echocardiogr 17:634-7. 2004
    ..Reflex tachycardia during the Valsalva maneuver and subsequent fusion of the E velocity and A velocity waves on the mitral velocity curves is a sign of normal left ventricular filling pressures...
  78. ncbi To the editor: functional imaging(FI) combines imaging datasets and computational fluid dynamics to simulate cardiac flows
    Ares Pasipoularides
    J Appl Physiol 105:1015; author reply 1019. 2008
  79. ncbi Alterations in transmural strains adjacent to ischemic myocardium during acute midcircumflex occlusion
    Filiberto Rodriguez
    Department of Cardiothoracic Surgery, Stanford University School of Medcine, Stanford, CA 94305 5247, USA
    J Thorac Cardiovasc Surg 129:791-803. 2005
    ..We studied alterations in transmural strains adjacent to ischemic myocardium during acute midcircumflex occlusion...
  80. ncbi Relation of myocardial histomorphometric features and left ventricular contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy
    Petar Otasevic
    Dr Aleksandar D Popovic Cardiovascular Research Center, Dedinje Cardiovascular Institute, Belgrade University Medical School, Milana Tepica 1, 11040 Belgrade, Serbia and Montenegro, Yugoslavia
    Eur J Heart Fail 7:49-56. 2005
    ..This study was designed to determine the relationship between histomorphometric features and contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy...
  81. ncbi Change in filling pattern with preload reduction reflects left ventricular relaxation
    Masaki Tanabe
    First Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    Int J Cardiol 98:67-72. 2005
    ..Accordingly, we hypothesized that the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved systolic function...
  82. ncbi Diastolic stress echocardiography: hemodynamic validation and clinical significance of estimation of ventricular filling pressure with exercise
    Malcolm I Burgess
    Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    J Am Coll Cardiol 47:1891-900. 2006
    ....
  83. ncbi Mitral annuloplasty as a ventricular restoration method for the failing left ventricle: a pilot study
    Tadaaki Koyama
    Department of Cardiovascular Surgery, Kyoto University, Graduate School of Medicine, Kyoto, Japan
    J Heart Valve Dis 16:195-9. 2007
    ..However, the direct benefits of this possible reshaping on LV function in the absence of underlying MR remain incompletely understood. The study aim was to identify these benefits in a canine model of acute heart failure...
  84. ncbi Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine
    S Laudi
    Department of Anesthesiology, Perioperative Care and Pain Medicine, University of Colorado, Health Sciences Center, Denver, Colorado, USA
    J Physiol Pharmacol 58:19-32. 2007
    ..Rats with I/R-injury showed increased left ventricular pressure (LVEDP) compared to rats without I/R-injury (p<0.005)...
  85. ncbi Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats
    F Akhavein
    Department of Pediatrics, McGill University and Division of Cardiology, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    J Appl Physiol 103:287-95. 2007
    ..The hearts were then excised and perfused in the constant pressure Langendorff mode to determine peak left ventricular pressure (LVP), the peak instantaneous rate of pressure increase (+dP/dtmax) and decrease (-dP/dtmax), as well as ..
  86. ncbi Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats
    Jen Ying Deng
    Department of Life Science, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
    Am J Physiol Heart Circ Physiol 293:H978-87. 2007
    ..In addition, the relaxation time constant of left ventricular pressure was prolonged in the HCF group...
  87. ncbi Ventricular untwisting: a temporal link between left ventricular relaxation and suction
    Yuichi Notomi
    Department of Cardiovascular Medicine F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 294:H505-13. 2008
    ..Untwisting rate may be a useful marker of diastolic function or even serve as a therapeutic target for improving diastolic function...
  88. ncbi Cardiac function and brain-type natriuretic peptide in first-time flash pulmonary edema
    Jacob P Dal-Bianco
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:289-96. 2008
    ..To assess left ventricular (LV) function and brain-type natriuretic peptide (BNP) in patients with first-time flash pulmonary edema (FPE)...
  89. ncbi Is left ventricular volume during diastasis the real equilibrium volume, and what is its relationship to diastolic suction?
    Wei Zhang
    Washington Univ Medical Center, St Louis, MO 63110, USA
    J Appl Physiol 105:1012-4. 2008
  90. ncbi Enhanced tolerance of the rat myocardium to ischemia and reperfusion injury early after acute myocardial infarction
    Constantinos Pantos
    Dept of Pharmacology, University of Athens, 75 Mikras Asias Ave, 11527 Goudi, Athens, Greece
    Basic Res Cardiol 102:327-33. 2007
    ..4-fold less in AMI, P < 0.05. In conclusion, the post-infarcted heart seems to be resistant to ischemiareperfusion injury and heat shock protein 70 and 27 may be involved in this response...
  91. ncbi Steroid treatment causes deterioration of myocardial function in the {delta}-sarcoglycan-deficient mouse model for dilated cardiomyopathy
    R Bauer
    Institute of Human Genetics, Newcastle University, International Center for Life, Newcastle upon Tyne NE1 3BZ, UK
    Cardiovasc Res 79:652-61. 2008
    ..The delta-sarcoglycan-deficient mouse (Sgcd-null) is a model for both limb girdle muscular dystrophy 2F (LGMD2F) and dilated cardiomyopathy...
  92. ncbi Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit
    Sharon L Hale
    Heart Institute of Good Samaritan Hospital and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles 90017, USA
    J Cardiovasc Pharmacol Ther 11:249-55. 2006
    ..Ranolazine treatment reduced myocardial stunning following brief ischemia/reperfusion suggesting that inhibiting the late sodium channel current may be a novel approach to treating stunning independent of effects on hemodynamics...
  93. ncbi Ventricular-arterial and ventricular-ventricular interactions and their relevance to diastolic filling
    Michael Frenneaux
    Department of Cardiovascular Medicine, University of Birmingham, Birmingham, United Kingdom
    Prog Cardiovasc Dis 49:252-62. 2007
    ....
  94. ncbi Early detection of anthracycline cardiotoxicity in a rabbit model: left ventricle filling pattern versus troponin T determination
    M Sterba
    Charles University in Prague, Faculty of Medicine in Hradec Kralove, Department of Pharmacology, Hradec Kralove, Czech Republic
    Physiol Res 56:535-45. 2007
    ..186+/-0.055 microg/l). Therefore, in contrast to complicated non-invasive evaluation of diastolic function, cTnT is shown to be an early and sensitive marker of anthracycline-induced cardiotoxicity in the rabbit model...
  95. ncbi Assessment of left ventricular systolic function using echocardiography in patients with preserved ejection fraction and elevated diastolic pressures
    Hisham Dokainish
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA
    Am J Cardiol 101:1766-71. 2008
    ..These differences are likely because invasively measured dP/dt and these echocardiographic variables measure different systolic properties in patients with preserved LV ejection fraction...
  96. ncbi Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion
    Lieve Lanoye
    Hydraulics Laboratory, Institute Biomedical Technology, St Pietersnieuwstraat 41, 9000 Gent, Belgium
    Exp Physiol 92:127-37. 2007
    ....
  97. pmc Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism
    Samuel C Lieber
    Dept of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, 185 South Orange Ave, MSB G 609, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 295:H860-6. 2008
    ..3-fold), whereas intact desmin decreased by 51%. Thus the cardiomyopathy of aging in old, conscious rats may be due not only to increases in collagen but also to alterations in cytoskeletal proteins...
  98. ncbi Noninvasive assessment of diastolic function in subjects with preserved left ventricular ejection fraction: usefulness of color kinetic imaging
    Yasuharu Takeda
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    J Card Fail 14:569-76. 2008
    ..Noninvasive assessment of left ventricular (LV) diastolic function is not established in patients with preserved ejection fraction. We investigated a relation between diastolic function and diastolic wall dynamics...
  99. ncbi Estimation of left ventricular filling pressure with exercise by Doppler echocardiography in patients with normal systolic function: a simultaneous echocardiographic-cardiac catheterization study
    Deepak R Talreja
    Sentara Virginia Beach General Hospital Eastern Virginia Medical School, Virginia Beach, Virginia, USA
    J Am Soc Echocardiogr 20:477-9. 2007
    ..However, the clinical use of Doppler echocardiography in the determination of filling pressures with exercise has been less well studied...
  100. ncbi Reversible pulmonary trunk banding. II. An experimental model for rapid pulmonary ventricular hypertrophy
    Carlos A Dias
    Heart Institute University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Thorac Cardiovasc Surg 124:999-1006. 2002
    ..An experimental model with a reversible pulmonary trunk banding device was developed with the aim of inducing rapid ventricular hypertrophy. The device consists of an insufflatable cuff connected to a self-sealing button...
  101. ncbi A novel water-soluble and cell-permeable calpain inhibitor protects myocardial and mitochondrial function in postischemic reperfusion
    Christiane Neuhof
    Department of Internal Medicine, Justus Liebig University of Giessen, Klinikstrasse 36, D 35392 Giessen, Germany
    Biol Chem 384:1597-603. 2003
    ..Left ventricular pressure amplitude and coronary flow showed significantly higher values during reperfusion in the presence of the ..

Research Grants62

  1. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..a reduction in cardiac hypertrophy, increased survival and preserved cardiac function in the face of left ventricular pressure overload...
  2. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..The system control is based on the left ventricular pressure and it successfully and consistently ejected 30 ml of blood during systole after the native ventricle ..
  3. Glial-Neural Interactions in Autonomic Control
    Richard C Rogers; Fiscal Year: 2012
    ..to the gut, physiological studies in head injury patients reveal that there is no correlation between ventricular pressure and the degree of gastric stasis...
  4. Induction of Cardiovascular Cells from hESCs by Embryonic Cues
    John W Lough; Fiscal Year: 2013
    ..of transplantation will be evaluated in terms of functional outcomes assessed by echocardiographic and ventricular pressure measurements, as well as by histological outcomes with the objective of engrafting damaged myocardium with ..
  5. TOXICITY OF CARDIAC HYPOXIA AND REOXYGENATION
    JAMES KEHRER; Fiscal Year: 1991
    ..Cardiac oxygen uptake, lactate dehydrogenase release, left ventricular pressure and coronary flow rates will be monitored...
  6. Allosteric Regulation of Myocardial Contraction
    JOHN MARSHALL ROBINSON; Fiscal Year: 2013
    ..The goal of this project is to establish mechanism of cooperative myofilament activation (Aim 1) and to establish the mechanism of altered myofilament sensitivity to Ca2+ (Aim II). ..
  7. INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEX
    David Ramsay; Fiscal Year: 1991
    ..Thus it is anticipated that the essential role of the left atrium in hormonal and thirst responses to simulated hypovolemia will be established and that the mechanism of these interactions will be elucidated...
  8. Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure
    Ghassan S Kassab; Fiscal Year: 2013
    ..based on magnetic resonance imaging and validated with in-vivo myocardial strain versus left and right ventricular pressure measurements...
  9. Assessment of Left Ventricle Function Using Color M-Mode Echocardiography
    Pavlos P Vlachos; Fiscal Year: 2012
    ..e. Vp, e', E/e', isovolumetric strain rate). ..
  10. Xanthine oxidase inhibitor for congestive heart failure
    Alex Nivorozhkin; Fiscal Year: 2002
    ..Cardiac contractility will be assessed using left ventricular pressure-volume analysis, dP/dT, stroke volume, and ejection fraction...
  11. CARDIAC RESPONSE TO ESTROGEN & HYPERTENSION
    MARK MORTON; Fiscal Year: 1991
    ..In vivo methodology will include: measurement of high fidelity left ventricular pressure, minor axis dimension, wall thickness, and stroke volume by electromagnetic flow sensor...
  12. THE TREATMENT OF PULMONARY HYPERTENSION
    James Pachence; Fiscal Year: 2000
    ..showed that the liposomal encapsulated poly[PEG-Lys-cHyp] was effective in decreasing into the right ventricular pressure and pulmonary artery collagen deposition that resulted from experimentally induced pulmonary hypertension...
  13. CONTRACTILE PERFORMANCE OF HYPERTROPHIED CARDIOCYTES
    Douglas Mann; Fiscal Year: 1991
    ..aim of this proposal is to establish whether the contractile defect in an experimental model of right ventricular pressure overload hypertrophy is a property of the cardiocyte itself, or whether instead it is a property of a ..
  14. Conductance to Measure Cardiac Mechanics
    Marc Feldman; Fiscal Year: 2001
    DESCRIPTION (Applicant's Description Verbatim): The application of left ventricular pressure-volume relationships to transgenic mice to precisely measure contractility is not widely available...
  15. EFFECTS OF HYPERTROPHY ON THE CORONARY CIRCULATION
    Kevin Dellsperger; Fiscal Year: 1991
    ..collateral growth may also be impaired; 3) to assess the effects of autonomic tone and increases in left ventricular pressure on the electrophysiological characteristics of ischemic cardiac muscle in normal and hypertrophied hearts; ..
  16. VENTRICULAR SYSTOLIC INTERACTIONS DURING HEART FAILURE
    David Farrar; Fiscal Year: 1993
    ..Our goal is to determine the isolated systolic effects on RV function of instantaneously reducing left ventricular pressure in a single beat without changing RV or LV end-diastolic pressure or volume...
  17. ETHANOL EFFECTS ON ISCHEMIC MYOCARDIUM
    PAUL PAGEL; Fiscal Year: 2000
    ..Regional systolic and diastolic function will be evaluated using left ventricular pressure-segment length diagrams...
  18. Analysis of Genomic and Proteomic Changes in Glia That Lead To Hydrocephalus
    Ken McCarthy; Fiscal Year: 2009
    ..All cases of HC are treated using shunts to decrease ventricular pressure. More than 30% of all new shunts fail in the first year and more than two thirds of new shunts fail during ..
  19. Treatment of Heart Disease with an Intraventricular Sac
    ZHENFANG ZHANG; Fiscal Year: 2006
    ..The divola protects the left ventricle from the harmful effects of high ventricular pressure during diastole, allowing for reverse remodelling (shrinkage) of a pathologically jenlarged ventricle...
  20. ENERGY DEPRIVATION MECHANISM IN DIABETIC CARDIOMYOPATHY
    MOHAMMED MATLIB; Fiscal Year: 2000
    ..will be subjected to increased workload and its effects on the increase in the rate of development of left ventricular pressure and relaxation of the pressure will be examined...
  21. MECHANISMS OF VENTRICULAR RESPONSE TO INFARCTION
    David Kass; Fiscal Year: 1990
    ..by which alterations in regional wall strain following myocardial infarction are related to global ventricular pressure-volume behavior, and compensatory adjustments to ischemic injury...
  22. LOAD REGULATION OF ADULT MAMMALIAN MYOCARDIUM
    George Cooper; Fiscal Year: 1993
    ..a segment of cat right ventricular myocardium in two settings; either at the time that generalized right ventricular pressure overload hypertrophy is initiated or after this hypertrophy is fully developed; both unloaded and over ..
  23. COLLAGEN AND THE HYPERTROPHIED HEART
    KARL WEBER; Fiscal Year: 1993
    Cardiac muscle is tethered within a fibrillar collagen matrix that serves to maximize force generation. Left ventricular pressure overload (LVPO) and hypertrophy (LVH) lead to excess collagen accumulation, or fibrosis (FIB)...
  24. CARDIOVASCULAR ROLE OF LEUKOTRIENES IN ANAPHYLAXIS
    SISTER JAKSCHIK; Fiscal Year: 1991
    ..rabbit, cardiac effects will be studied in the intact animal by monitoring systemic blood pressure, right ventricular pressure and electrocardiogram...
  25. PHOSPHORUS NUCLEAR MAGNETIC RESONANCE ON CARDIAC TISSUE
    WILLIAM JACOBUS; Fiscal Year: 1980
    ..Left ventricular pressure will be measured under all experimental conditions...
  26. METABOLIC CONTROL OF CORONARY FLOW--31P NMR SPECTROSCOPY
    Gregory Schwartz; Fiscal Year: 1992
    ..the potential abnormalities of such regulation in experimental models of coronary artery disease, left ventricular pressure or volume overload, or in the clinical syndrome of "impaired coronary vasodilator reserve"...
  27. MOLECULAR AND CELLULAR BIOLOGY OF CARDIAC INTERSTITIUM
    MAHBOUBEH EGHBALI WEBB; Fiscal Year: 1993
    ..of steady state levels of mRNA; and post-translational level by measurement of enzyme activity in left ventricular pressure overload hypertrophy...
  28. STIFFNESS IN HYPERTROPHY-ROLE OF CARDIOCYTE CYTOSKELETON
    Michael Zile; Fiscal Year: 2000
    ..Studies will be performed in cardiocytes and papillary muscles isolated from normal cats, cats with right ventricular pressure-overload hypertrophy and cats with right ventricular volume-overload hypertrophy...
  29. Myocardial Hypertrophy and Therapeutic Angiogenesis
    Ingeborg Friehs; Fiscal Year: 2009
    ..In a model of left ventricular pressure-overload hypertrophy in immature rabbits, we will investigate whether an increase in diffusion distance ..
  30. BASIC AND CLINICAL STUDIES OF CARDIAC FUNCTION
    J Rankin; Fiscal Year: 1992
    ..Left ventricular dimensions will be measured with ultrasonic transducers, ventricular pressure will be obtained with a micromanometer, and cardiac output will be assessed with Doppler techniques...
  31. Murine Cardiovascular MRI
    Robert Weiss; Fiscal Year: 2003
    ..be assessed in mice with post-infarction heart failure, inherited proneness to dilated cardiomyopathy, left ventricular pressure-overload, chloride channel deficiency, sepsis, and ischemia-reperfusion injury...
  32. CARDIOVASCULAR CONTROL DURING DYNAMIC EXERCISE
    George Ordway; Fiscal Year: 1990
    ..calculated include heart rate, cardiac output, arterio-venous oxygen difference, oxygen consumption, left ventricular pressure, and left ventricular dP/dt...
  33. MOLECULAR AND CELLULAR BIOLOGY OF CARDIAC INTERSTITIUM
    REZA BASHEY; Fiscal Year: 1993
    ..Hypertensive Rats (SHR), a model of essential hypertension which resembles the major cause of chronic left ventricular pressure overload in man, and 2) Cardiac hypertrophy induced in rats by abdominal aortic constriction...
  34. PROTEIN KINASE C EFFECTS ON SENESCENT HEART FUNCTION
    Peter Buttrick; Fiscal Year: 1999
    ..shown that overexpression of PKC in hearts of adult transgenic mice results in an increased rate of left ventricular pressure redevelopment following global ischemia when compared to control hearts...
  35. CARDIODYNAMICS AND HYPERTENSION UNDER CEREBELLAR CONTROL
    Kenneth Dormer; Fiscal Year: 1980
    ..Conscious dogs instrumented for measuring of arterial or left ventricular pressure, heart rate, coronary or renal blood flow, will be recorded from during submaximal treadmill exercise ..
  36. VENTRICULAR INTERDEPENDENCE
    WILLIAM SANTAMORE; Fiscal Year: 1990
    ..four equations will be derived to explain the changes in ventricular pressure or volume caused by changing the pressure or volume of the contralateral ventricle...
  37. CONTROL OF SUGAR ENTRY IN NORMAL AND DIABETIC HEART
    CAROL WHITFIELD; Fiscal Year: 1980
    ..system in isolated, perfused hearts of normal and diabetic animals performing at various levels of ventricular pressure development, to examine the hypothesis that 1) a defect in transport exists in diabetic heart which ..
  38. MECHANISMS OF CARDIOVASCULAR COMPLICATIONS IN AIDS
    Krishna Agrawal; Fiscal Year: 2003
    ..output, and (c) left ventricular contractility by measuring changes and the rate of change in the left ventricular pressure; and (4) to determine the role of Tat protein in modulating cardiovascular function...
  39. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  40. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    ..abstract_text> ..
  41. Hydrocephalus, Intracranial Pressure and Neurocognition
    David Frim; Fiscal Year: 2006
    ..At the study conclusion, derived data should also practically affect the surgical choice of shunting products. ..
  42. Myocardial Protection in the Aging Heart
    DAVID STOWE; Fiscal Year: 2003
    ..The long term objectives of this project, as a new research area for this laboratory, are to investigate new interventions which may protect the aged myocardium from ischemia/reperfusion injury. ..
  43. MYOCARDIAL CALCIUM HANDLING DURING AND AFTER HYPOTHERMIA
    DAVID STOWE; Fiscal Year: 2002
    ..Na+ and H+ mitochondrial Ca2+, and phasic diastolic and systolic myoplasmic Ca+ fluorometrically, with left ventricular pressure (LVP) and other functional and metabolic variables in intact beating hearts; whole cell voltage-clamped Na+,..
  44. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2008
    ..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..
  45. Pulse Doppler Ultrasound Imaging System
    JOAN CARROLL; Fiscal Year: 2004
    ..abstract_text> ..
  46. SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISE
    JOAN CARROLL; Fiscal Year: 2004
    ..Because such a large segment of the American population is overweight or obese, the knowledge and insight gained from these studies can have far-reaching effects. ..
  47. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2004
    ..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole. ..
  48. SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISE
    JOAN CARROLL; Fiscal Year: 2004
    ..Because such a large segment of the American population is overweight or obese, knowledge and insight gained from these studies can have far-reaching effects. ..
  49. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2001
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
  50. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2001
    ....
  51. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  52. ATRIAL NATRIURETIC PEPTIDE AND RECEPTOR GENES IN HYPOXIA
    Yiu Fai Chen; Fiscal Year: 2010
    ..Our proposed mechanistic studies will lead to innovative and effective therapeutic approaches to this important cause of morbidity and mortality in the American population. ..
  53. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  54. ANP Modulates Cardiac Remodeling via Cardiac Fibroblasts
    Yiu Fai Chen; Fiscal Year: 2009
    ..These mechanistic studies will provide a more rational basis for therapeutic intervention in patients with cardiac dysfunction/failure, many of whom have decreased levels of ANP. ..
  55. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  56. Development and Clinical Testing of CorAide RVAD/BVAD
    Kiyotaka Fukamachi; Fiscal Year: 2008
    ..The successful completion of this program will provide clinicians and patients with a safe and effective option for outpatient mechanical support that allows an excellent quality of life. ..
  57. Improving the Wegner Hall Vivarium
    BRYAN SLINKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. Enhanced cardiac sympathetic afferent reflex in CHF
    Wei Wang; Fiscal Year: 2004
    ....
  59. A3 Adenosine Receptors Cardioprotective Mechanisms
    John Auchampach; Fiscal Year: 2007
    ..The isolated mouse heart model will be used to correlate post-ischemic contractile function (left ventricular pressure) and cell necrosis (LDH released) with metabolic state (high-energy phosphates), mitochondrial integrity (..
  60. MECHANISM & THERAPY OF POST-MI MITRAL REGURGITATION
    Judy Hung; Fiscal Year: 2005
    ..abstract_text> ..
  61. Development of Mouse Model to Study Fibroblast Functions
    RANDY COWLING; Fiscal Year: 2007
    ..Thus, this proposal seeks to develop a model that will be useful across many disciplines of health-related research. [unreadable] [unreadable]..