vascular resistance

Summary

Summary: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.

Top Publications

  1. ncbi Expert consensus document on arterial stiffness: methodological issues and clinical applications
    Stephane Laurent
    Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
    Eur Heart J 27:2588-605. 2006
  2. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
  3. ncbi Operative classification of thromboembolic disease determines outcome after pulmonary endarterectomy
    Patricia A Thistlethwaite
    Divisions of Cardiothoracic Surgery, Biostatistics, and Cardiology, University of California, San Diego, Calif 92103 8892, USA
    J Thorac Cardiovasc Surg 124:1203-11. 2002
  4. ncbi The Fontan circulation: who controls cardiac output?
    Marc Gewillig
    Paediatric and Congenital Cardiology, University Hospitals Leuven, Belgium
    Interact Cardiovasc Thorac Surg 10:428-33. 2010
  5. ncbi Effect of antenatal betamethasone administration on placental vascular resistance
    E M Wallace
    Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia
    Lancet 353:1404-7. 1999
  6. pmc Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays
    M Centlow
    Departments of Obstetrics and Gynecology and Clinical Sciences, Lund University, BMC C14, Klinikgatan 28, 221 84 Lund, Sweden
    J Pregnancy 2011:472354. 2011
  7. pmc Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension
    Kendall S Hunter
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Am Heart J 155:166-74. 2008
  8. ncbi Cellular and molecular pathobiology of pulmonary arterial hypertension
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, UPRES EA2705, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 43:13S-24S. 2004
  9. ncbi Arterial stiffness in preeclamptic and chronic hypertensive pregnancies
    Kati M H Tihtonen
    Department Obstetrics and Gynecology, Tampere University Hospital, PL 2000, 33521 Tampere, Finland
    Eur J Obstet Gynecol Reprod Biol 128:180-6. 2006
  10. ncbi Circulatory function and hepatorenal syndrome in cirrhosis
    Luis Ruiz-del-Arbol
    Hepatic Hemodynamic Unit, Gastroenterology Department, Hospital Ramon y Cajal, University of Alcala, Ctra de Colmenar Viejo Km 9 1, 28034 Madrid, Spain
    Hepatology 42:439-47. 2005

Detail Information

Publications299 found, 100 shown here

  1. ncbi Expert consensus document on arterial stiffness: methodological issues and clinical applications
    Stephane Laurent
    Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
    Eur Heart J 27:2588-605. 2006
    ....
  2. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
    ..The objective of this investigation was to determine whether aPWV is associated with total and cardiovascular (CV) mortality and CV events in a community-dwelling sample of older adults...
  3. ncbi Operative classification of thromboembolic disease determines outcome after pulmonary endarterectomy
    Patricia A Thistlethwaite
    Divisions of Cardiothoracic Surgery, Biostatistics, and Cardiology, University of California, San Diego, Calif 92103 8892, USA
    J Thorac Cardiovasc Surg 124:1203-11. 2002
    ..We sought to determine whether type and location of thromboembolic disease in the pulmonary vascular tree predicts the hemodynamic result and clinical outcome in patients undergoing pulmonary endarterectomy...
  4. ncbi The Fontan circulation: who controls cardiac output?
    Marc Gewillig
    Paediatric and Congenital Cardiology, University Hospitals Leuven, Belgium
    Interact Cardiovasc Thorac Surg 10:428-33. 2010
    ..analyses the role of contractility, heart rate, and afterload and highlights the importance of pulmonary vascular resistance (PVR) in determining adequate preload and, therefore, cardiac output in these patients...
  5. ncbi Effect of antenatal betamethasone administration on placental vascular resistance
    E M Wallace
    Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia
    Lancet 353:1404-7. 1999
    High placental vascular resistance is an important cause of fetal growth restriction and subsequent perinatal mortality...
  6. pmc Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays
    M Centlow
    Departments of Obstetrics and Gynecology and Clinical Sciences, Lund University, BMC C14, Klinikgatan 28, 221 84 Lund, Sweden
    J Pregnancy 2011:472354. 2011
    ..Increased expression of antigen-presenting genes, as seen in the notch-only placenta, may prevent this inflammatory response and, thereby, protect the patient from developing pre-eclampsia...
  7. pmc Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension
    Kendall S Hunter
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Am Heart J 155:166-74. 2008
    Pulmonary vascular resistance (PVR) is the current standard for evaluating reactivity in children with pulmonary arterial hypertension (PAH)...
  8. ncbi Cellular and molecular pathobiology of pulmonary arterial hypertension
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, UPRES EA2705, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 43:13S-24S. 2004
    ..Vasoconstriction, remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary vascular resistance in PAH...
  9. ncbi Arterial stiffness in preeclamptic and chronic hypertensive pregnancies
    Kati M H Tihtonen
    Department Obstetrics and Gynecology, Tampere University Hospital, PL 2000, 33521 Tampere, Finland
    Eur J Obstet Gynecol Reprod Biol 128:180-6. 2006
    ..To assess arterial stiffness in pregnancies complicated by hypertensive disorders: preeclampsia and chronic hypertension...
  10. ncbi Circulatory function and hepatorenal syndrome in cirrhosis
    Luis Ruiz-del-Arbol
    Hepatic Hemodynamic Unit, Gastroenterology Department, Hospital Ramon y Cajal, University of Alcala, Ctra de Colmenar Viejo Km 9 1, 28034 Madrid, Spain
    Hepatology 42:439-47. 2005
    ..Peripheral vascular resistance was decreased to the same extent in the two groups...
  11. ncbi Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow
    Eric J Belin De Chantemele
    INSERM U771, Angers, France
    Cardiovasc Res 81:788-96. 2009
    ..Thus, we studied the structural and functional adaptation of RAs from Zucker diabetic fatty (ZDF) and lean Zucker (LZ) rats to chronic changes in flow...
  12. pmc Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation
    Emma C Hart
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 53:571-6. 2009
    ..These findings may have important implications for understanding how hypertension and other disorders of blood pressure regulation occur in men and women...
  13. ncbi Reactive oxygen species are necessary for high flow (shear stress)-induced diameter enlargement of rat resistance arteries
    Eric J Belin De Chantemele
    INSERM, Angers, France
    Microcirculation 16:391-402. 2009
    ..Remodeling requires cell growth and migration, which may involve reactive oxygen species (ROS). Nevertheless, the role of ROS in flow-mediated remodeling in resistance arteries is not known...
  14. ncbi Evolution and predictors of morphological and functional arterial changes in the course of type 1 diabetes mellitus
    Ildikó Vastagh
    Department of Neurology, Semmelweis University Faculty of Medicine, Budapest, Hungary
    Diabetes Metab Res Rev 26:646-55. 2010
    ..Diabetes mellitus results in accelerated atherosclerosis. We evaluated preclinical, morphological and functional vascular changes in type 1 diabetes mellitus...
  15. ncbi Relation of arterial stiffness to left ventricular diastolic function and cardiovascular risk prediction in patients > or =65 years of age
    Walter P Abhayaratna
    Division of Cardiovascular Diseases and Internal Medicine, Rochester, Minnesota, USA
    Am J Cardiol 98:1387-92. 2006
    ..Aortic PP, brachial PP, and PWV appeared superior to AP in risk discrimination in this elderly cohort...
  16. ncbi Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, Florida, USA
    Am J Hypertens 18:3S-10S. 2005
    ..Therefore, optimal treatment of high BP and its complications should include consideration of arterial stiffness, augmentation of aortic pressure, and LV wasted energy, all of which should be reduced to the lowest possible level...
  17. pmc Cardiovascular autonomic neuropathy, HDL cholesterol, and smoking correlate with arterial stiffness markers determined 18 years later in type 1 diabetes
    Catherine T Prince
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:652-7. 2010
    ..This association persists after adjustment for potential confounders as well as for baseline HbA(1), HDL cholesterol, and smoking history, which were also associated with these PWA measures...
  18. ncbi Effect of burst-mode transcutaneous electrical nerve stimulation on peripheral vascular resistance
    J E Sherry
    4176 Medical Sciences Center, 1300 University Ave, Madison, WI 53706 1532, USA
    Phys Ther 81:1183-91. 2001
    ..low-frequency (2 bursts per second), burst-mode transcutaneous electrical nerve stimulation (TENS) on calf vascular resistance, a more direct marker of sympathetic vasoconstrictor outflow than skin temperature, in subjects with no ..
  19. ncbi Pulmonary endarterectomy: recent changes in a single institution's experience of more than 2,700 patients
    Michael M Madani
    Division of Cardiovascular and Thoracic Surgery, University of California San Diego Medical Center, San Diego, California, USA
    Ann Thorac Surg 94:97-103; discussion 103. 2012
    ..This article summarizes the most recent outcomes of pulmonary endarterectomy at a single institution over the past 12 years, with emphasis on the surgical approach to segmental-level chronic thromboembolic disease...
  20. pmc Time-dependent changes in autonomic control of splanchnic vascular resistance and heart rate in ANG II-salt hypertension
    Marcos T Kuroki
    Dept of Integrative Biology and Physiology, 321 Church St SE, Rm 6 125 Jackson Hall, Minneapolis, MN 55455, USA
    Am J Physiol Heart Circ Physiol 302:H763-9. 2012
    ..Mean arterial pressure (MAP), heart rate (HR), superior mesenteric artery blood flow, and mesenteric vascular resistance (MVR) were measured during 4 control days, 14 days of ANG II delivered subcutaneously (150 ng·kg(-1)·min(-..
  21. ncbi Transcranial Doppler pulsatility indices as a measure of diffuse small-vessel disease
    C S Kidwell
    Stroke Center, Department of Neurology, 710 Westwood Plaza, UCLA Medical Center, Los Angeles, CA 90095, USA
    J Neuroimaging 11:229-35. 2001
    Elevation in pulsatility indices (PIs) as measured by transcranial Doppler (TCD) have been postulated to reflect downstream increased vascular resistance caused by small-vessel ischemic disease.
  22. pmc A review of pulmonary arterial hypertension: role of ambrisentan
    Robyn J Barst
    New York Presbyterian Pulmonary Hypertension Center, Columbia University College of Physicians and Surgeons, 3959 Broadway, BHN 2 255, NewYork, NY 10032, USA
    Vasc Health Risk Manag 3:11-22. 2007
    ..The demonstration of clinical efficacy, low incidence of acute hepatic toxicity, and low risk of drug-drug interactions support the role of ambrisentan for the treatment of PAH...
  23. ncbi Pathophysiology of sepsis-induced acute kidney injury: the role of global renal blood flow and renal vascular resistance
    Adrien Bouglé
    département d anesthésie réanimation chirurgicale, Université Paris XI Sud, Hopital de Bicetre, Assistance Publique, Hopitaux de Paris, Le Kremlin Bicetre, France
    Contrib Nephrol 174:89-97. 2011
    ..Increased renal vascular resistance (RVR) may represent a key hemodynamic factor that is involved in sepsis-associated AKI...
  24. ncbi Pulmonary arterial capacitance in children with idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease: relation to pulmonary vascular resistance, exercise capacity, and survival
    Imran Sajan
    Pediatric Cardiac Critical Care, The Heart Institute for Children, Advocate Hope Children s Hospital, Oak Lawn, IL, USA
    Am Heart J 162:562-8. 2011
    ..However, the relation of PAC to pulmonary vascular resistance (PVR), exercise endurance, and survival is poorly defined in children.
  25. doi Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice
    Nikolaos A Maniatis
    Am J Physiol Lung Cell Mol Physiol 294:L865-73. 2008
    ..We measured pulmonary vascular resistance (PVR) and assessed alterations in small pulmonary arteries to determine the basis of the hypertension...
  26. ncbi Sympathetic and haemodynamic responses to lipids in healthy human ageing
    John P Florian
    Intercollege Graduate Degree Program in Physiology and Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Exp Physiol 95:486-97. 2010
    Plasma non-esterified fatty acids (NEFAs) activate the sympathetic nervous system and increase vascular resistance and blood pressure (BP); however, the response with ageing is not known...
  27. ncbi Wall shear stress in the superficial femoral artery of healthy adults and its response to postural changes and exercise
    O Schlager
    Division of Angiology, Department of Medicine II, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur J Vasc Endovasc Surg 41:821-7. 2011
    ..We investigated the course of WSS and its response to postural changes and exercise along the SFA of healthy adults...
  28. ncbi Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 51:432-9. 2008
    ....
  29. ncbi RC time constant of single lung equals that of both lungs together: a study in chronic thromboembolic pulmonary hypertension
    N Saouti
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H2154-60. 2009
    ..The RC time of a single lung equals that of both lungs together, and pulmonary arterial compliance comes largely from the distal vasculature...
  30. ncbi Diabetes and arterial stiffening
    Nathaniel Winer
    Division of Endocrinology, Diabetes, and Hypertension, SUNY Downstate Medical Center, New York, NY 11203 2098, USA
    Adv Cardiol 44:245-51. 2007
    ....
  31. ncbi Dynamic cerebral autoregulation in subjects with Alzheimer's disease, mild cognitive impairment, and controls: evidence for increased peripheral vascular resistance with possible predictive value
    Erik D Gommer
    Department of Clinical Neurophysiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Alzheimers Dis 30:805-13. 2012
    ..AD, p = 0.004). In conclusion, AD patients compared to MCI patients and controls have increased CVRi, whereas dCA parameters do not seem to differentiate AD patients. For MCI patients, CVRi might have predictive value in developing AD...
  32. ncbi Calcium channel blockade prevents pressure-dependent inward remodeling in isolated subendocardial resistance vessels
    Oana Sorop
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1236-45. 2006
    ..Although microvascular pressure profiles distal to stenoses are poorly defined, these data suggest that vasodilator therapy could improve subendocardial microvascular function and structure in coronary artery disease...
  33. ncbi Pulmonary vascular resistance, collateral flow, and ventricular function in patients with a Fontan circulation at rest and during dobutamine stress
    Boris Schmitt
    Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Berlin and The Charité, Medical University Berlin, Berlin, Germany
    Circ Cardiovasc Imaging 3:623-31. 2010
    ..The role, interplay, and relative importance of the multifactorial hemodynamic and myocardial mechanisms causing dysfunction of the Fontan circulation remain incompletely understood...
  34. ncbi Vascular resistance in the prostate evaluated by colour Doppler ultrasonography: is benign prostatic hyperplasia a vascular disease?
    Andreas P Berger
    Department of Urology and Radiology, Medical University of Innsbruck, Austria
    BJU Int 98:587-90. 2006
    To evaluate prostatic vascular resistance by measuring the resistive index (RI), and flow velocity using colour Doppler ultrasonography (CDUS), in normal prostates and in patients with benign prostatic hyperplasia (BPH) or prostate ..
  35. ncbi Cardiopulmonary effects of low-dose arginine vasopressin in ovine acute lung injury
    Martin Westphal
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 39:357-63. 2011
    ..To elucidate the effects of low-dose arginine vasopressin on cardiopulmonary functions and nitrosative stress using an established model of acute lung injury...
  36. ncbi The relationship between cortisol concentrations in pregnancy and systemic vascular resistance in childhood
    Patrícia Helen Carvalho Rondó
    Nutrition Department, School of Public Health, University of Sao Paulo, Avenida Dr Arnaldo 715, Sao Paulo, SP, CEP 01246 904, Brazil
    Early Hum Dev 86:127-31. 2010
    To assess the relationship between cortisol concentrations in the last trimester of pregnancy and systemic vascular resistance - SVR in childhood.
  37. ncbi Oxidised low-density lipoprotein and arterial function in beta-thalassemia major
    Dimitrios A Stakos
    Cardiology Division, Democritus University of Thrace, Alexandroupolis, Greece
    Eur J Haematol 82:477-83. 2009
    ..Increased concentrations of oxidised low-density lipoprotein cholesterol (oxLDL) have been observed in those patients, but possible associations between oxLDL and arterial function in beta-TM have not been defined...
  38. pmc Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor?
    Gregory B Waypa
    Department of Pediatrics, Division of Neonatology, Northwestern University, Morton Building 4 685, 310 East Superior St, Chicago, IL 60611, USA
    Respir Physiol Neurobiol 174:201-11. 2010
    ....
  39. ncbi Impaired resistance artery function in patients with end-stage renal disease
    Natallia Luksha
    Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Sci (Lond) 120:525-36. 2011
    ..The reduced contribution of NO to flow stimulus via enhanced nitrosative stress and higher plasma concentrations of ADMA may suggest potential mechanisms behind endothelial dysfunction in the resistance peripheral circulation in ESRD...
  40. ncbi Clonidine lowers blood pressure by reducing vascular resistance and cardiac output in young, healthy males
    Anna Mitchell
    Department of Nephrology, University of Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Cardiovasc Drugs Ther 19:49-55. 2005
    ....
  41. ncbi Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Circulation 111:2741-7. 2005
    ..The aim of the present study was to examine whether Rho-kinase is involved in the peripheral circulation abnormalities of HF in humans with the Rho-kinase inhibitor fasudil...
  42. ncbi Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance
    Giancarla A Botelho-Santos
    Laboratório de Hipertensão, Dept de Fisiologia e Biofísica, Univ Federal de Minas Gerais, Av Antonio Carlos, 6627 ICB, 31270 901 Belo Horizonte, MG, Brazil
    Am J Physiol Heart Circ Physiol 292:H2485-90. 2007
    ..0 vs. 359 +/- 6.0 beats/min in SD). Strikingly, TGR(A1-7)3292 rats presented a substantial decrease in the vascular resistance in lung, spleen, kidney, adrenals, brain, testis and brown fat tissue with no significant differences in ..
  43. pmc Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Br J Clin Pharmacol 53:189-92. 2002
    ..To investigate the role of basal nitric oxide (NO) production in regulating large artery stiffness in vivo...
  44. doi Portal hypertension and its complications
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Gastroenterology 134:1715-28. 2008
  45. ncbi On coupling a lumped parameter heart model and a three-dimensional finite element aorta model
    H J Kim
    Department of Mechanical Engineering, Stanford University, 18 Campus Drive, Stanford, CA 94305, USA
    Ann Biomed Eng 37:2153-69. 2009
    ..We demonstrate this method in a patient-specific model of a normal human thoracic aorta under rest and exercise conditions and an aortic coarctation model under pre- and post-interventions...
  46. ncbi Characterization of circulatory disorders in beta-thalassemic mice by noninvasive ultrasound biomicroscopy
    Ekatherina Stoyanova
    University of Montreal Hospital Research Center, Montreal, Quebec, Canada
    Physiol Genomics 29:84-90. 2007
    ..In our beta-thalassemic mice, total peripheral vascular resistance was significantly increased (P < 0...
  47. ncbi Small artery remodeling: current concepts and questions
    Jeroen van den Akker
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Vasc Res 47:183-202. 2010
    ....
  48. ncbi The influence of smoking cessation on hemodynamics and arterial compliance
    Shmuel Oren
    Internal Medicine Department A Barzilai Medical Center, Ashkelon, Israel
    Angiology 57:564-8. 2006
    ..The authors conclude that smoking cessation improves arterial stiffness as assessed by the augmentation index, owing mainly to increasing the small artery compliance, which is known to be an early index of endothelial damage...
  49. ncbi Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair
    Phalla Ou
    Department of Pediatric Radiology, Hopital Necker Enfants Malades, University Rene Descartes Paris 5, Paris, France
    Am Heart J 155:187-93. 2008
    ..Hypertension occurs in 20% to 40% of survivors of anatomically successful repair of aortic coarctation (CoA). The aim of the present study was to examine the role of central aortic function in this setting...
  50. ncbi Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism
    M Keith Wilkerson
    Dept of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Am J Physiol Heart Circ Physiol 288:H1652-61. 2005
    ..and that an enhanced vasoconstriction described in vitro will alter regional cerebral blood flow (CBF) and vascular resistance (CVR) during standing and head-up tilt...
  51. pmc Associations of renal vascular resistance with albuminuria and other macroangiopathy in type 2 diabetic patients
    Kumiko Hamano
    Department of Diabetology and Endocrinology, Shonan Kamakura General Hospital, Kanagawa, Japan
    Diabetes Care 31:1853-7. 2008
    ..We studied whether renal vascular resistance (resistive index [RI]) of the main renal arteries could be associated with albuminuria and further assessed ..
  52. pmc Key role of the NO-pathway and matrix metalloprotease-9 in high blood flow-induced remodeling of rat resistance arteries
    Odile Dumont
    UMR CNRS 6214 Inserm 771, Faculte de Medecine, Universite d Angers, 49045 Angers, France
    Arterioscler Thromb Vasc Biol 27:317-24. 2007
    ..We hypothesized that the NO pathway and matrix metalloproteases (MMPs) activation might play a role in flow (shear stress)-induced microvascular remodeling...
  53. ncbi Influence of the menstrual cycle, pregnancy, and preeclampsia on arterial stiffness
    Amy O Robb
    Centres for Reproductive Biology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Hypertension 53:952-8. 2009
    ..These effects may contribute to adverse cardiovascular outcomes of pregnancy and preeclampsia...
  54. ncbi Contribution of systemic vascular resistance and total arterial compliance to effective arterial elastance in humans
    Denis Chemla
    Service de Physiologie Cardio Respiratoire, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, 94 275 Le Kremlin Bicêtre Cedex, France
    Am J Physiol Heart Circ Physiol 285:H614-20. 2003
    The respective contribution of systemic vascular resistance (R) and total arterial compliance (C) to the arterial load remains to be established in humans. Effective arterial elastance (Ea), i.e...
  55. ncbi Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension
    Jan Willem Lankhaar
    Department of Physics and Medical Technology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur Heart J 29:1688-95. 2008
    ..afterload, but for monitoring of treatment of pulmonary hypertension (PH) most often still only pulmonary vascular resistance (R) is used...
  56. ncbi Exercise training, vascular function, and functional capacity in middle-aged subjects
    A Maiorana
    Department of Human Movement and Exercise Science, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, Western Australia
    Med Sci Sports Exerc 33:2022-8. 2001
    ..This finding contrasts with previous studies in subjects with type 2 diabetes and heart failure that employed an identical training program...
  57. pmc Impaired sympathetic vascular regulation in humans after acute dynamic exercise
    J R Halliwill
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Physiol 495:279-88. 1996
    1. The reduction in vascular resistance which accompanies acute dynamic exercise does not subside immediately during recovery, resulting in a post-exercise hypotension...
  58. ncbi Vascular compliance is reduced in the early stages of type 1 diabetes
    J S Romney
    Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Care 24:2102-6. 2001
    ..Larger prospective studies are required to confirm this finding and to investigate the efficacy of medical intervention...
  59. ncbi Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries
    Kevin Retailleau
    Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 771, Angers, France
    Hypertension 55:339-44. 2010
    ..Thus, in type 2 diabetic rats, superoxide and thromboxane A(2) reduced AT2R-induced dilation. These findings are important to take into consideration when choosing vasoactive drugs for diabetic patients...
  60. ncbi The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging
    Oliver J Rider
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Obesity (Silver Spring) 18:2311-6. 2010
    ..Significant weight loss results in improvements in aortic PWV. This may provide a potential link between both obesity and increased mortality, and the reduction in mortality that occurs with weight loss...
  61. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
    ..Few population studies addressed the prognostic significance of aortic pulse wave velocity (APWV) above and beyond other cardiovascular risk factors...
  62. ncbi Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension
    H Kimura
    Department of Chest Medicine, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8679, Japan
    Am J Respir Crit Care Med 164:319-24. 2001
    ..The plasma level of MCP-1 was significantly correlated with pulmonary vascular resistance. In IL-1beta and TNF-alpha, on the other hand, there was no correlation between cytokines and pulmonary ..
  63. pmc Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries
    E J Belin de Chantemèle
    INSERM U 771, Angers, France
    Arterioscler Thromb Vasc Biol 28:2216-24. 2008
    ..Genetic studies in human and mice revealed a critical role for Notch3 in the structural integrity of distal resistance arteries by regulating arterial differentiation and postnatal maturation...
  64. ncbi Resistive index in chronic nephropathies: predictive value of renal outcome
    G Splendiani
    Department of Nephrology, Tor Vergata University of Rome, Italy
    Clin Nephrol 57:45-50. 2002
    ..In recent nephrological literature, many papers deal with the correlations between resistive index, anatomo-pathological patterns and renal function...
  65. ncbi Endocrine factors related to changes in total peripheral vascular resistance after treatment of thyrotoxic and hypothyroid patients
    M J Diekman
    Department of Endocrinology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Eur J Endocrinol 144:339-46. 2001
    OBJECTIVE: Total peripheral vascular resistance (TPR) decreases in thyrotoxicosis and increases in hypothyroidism...
  66. ncbi 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes
    Mariona Graupera
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malaties Digestives Hospital Clinic, University of Barcelona, Barcelona, Spain
    Gastroenterology 122:387-93. 2002
    Cysteinyl-leukotrienes (Cys-LTs) increase intrahepatic vascular resistance in normal rat livers. CCl4 cirrhotic rat livers have increased Cys-LT production and 5-lipoxygenase messenger RNA (mRNA) expression...
  67. ncbi Impact of intradialytic exercise on arterial compliance and B-type natriuretic peptide levels in hemodialysis patients
    Nigel D Toussaint
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
    Hemodial Int 12:254-63. 2008
    ....
  68. pmc Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?
    Christian F Opitz
    Department of Internal Medicine, DRK Kliniken Berlin, Köpenick, Berlin, Germany
    Eur Heart J 29:1936-48. 2008
    ..These characteristics bear more relation to the chemical or pharmacological properties of the drugs than to receptor selectivity itself...
  69. ncbi Testing of cerebral endothelium function with L-arginine after stroke
    B Zvan
    Department of Neuoradiology, University Medical Center Ljubljana, Ljubljana, Slovenia
    Int Angiol 21:256-9. 2002
    ..To determine cerebral vascular endothelial function in the early stages after ischemic stroke, we studied cerebrovascular reactivity to L-A with transcranial Doppler (TCD)...
  70. ncbi Endothelial function of young healthy males following whole body resistance training
    M Rakobowchuk
    Dept of Kinesiology, Ivor Wynne Centre, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Appl Physiol 98:2185-90. 2005
    ..Thus arterial adaptations with high-pressure loads, such as those experienced during resistance exercise, may be quite different compared with endurance training...
  71. ncbi Postchallenge hyperglycaemic spike associate with arterial stiffness
    C L Huang
    Department of Internal Medicine, University Hospital, National Taiwan University College of Medicine, 7 Chung Shan South Road, Taipei 100, Taiwan
    Int J Clin Pract 61:397-402. 2007
    ..In subjects without clinical diagnosis of type 2 diabetes, postchallenge hyperglycaemic spike is highly associated with CAVI, a good parameter of aortic stiffness, independent of age, gender and blood pressure...
  72. ncbi Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity
    D R Webb
    Diabetes and Vascular Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
    Diabetologia 53:1190-8. 2010
    ..We used carotid-femoral pulse wave velocity ((cf)PWV) to quantify independent associations of fasting glucose, post-challenge glucose and derived insulin resistance (HOMA-IR) with aortic stiffness...
  73. ncbi Noninvasive estimation of pulmonary vascular resistance in pulmonary hypertension
    Navin Rajagopalan
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Echocardiography 26:489-94. 2009
    Determination of pulmonary vascular resistance (PVR) in patients with suspected or known pulmonary hypertension (PH) requires right heart catheterization. Our purpose was to use Doppler echocardiography to estimate PVR in patients with PH.
  74. pmc Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis
    Q Zhou
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Gut 55:1296-305. 2006
    ..Activation of the RhoA/Rho-kinase pathway is essential for contraction of vascular smooth muscle. The aim of this study was to investigate RhoA/Rho-kinase mediated regulation of the intrahepatic vascular tone in cirrhotic rats...
  75. ncbi Rapid and extensive arterial adaptations after spinal cord injury
    Patricia C de Groot
    Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arch Phys Med Rehabil 87:688-96. 2006
    ..To assess the time course of adaptations in leg vascular dimension and function within the first 6 weeks after a spinal cord injury (SCI)...
  76. ncbi Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats
    Massimo Bolognesi
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    J Pharmacol Exp Ther 321:187-94. 2007
    ....
  77. ncbi Maternal smoking during pregnancy, fetal arterial resistance adaptations and cardiovascular function in childhood
    J J M Geelhoed
    The Generation R Study Group Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    BJOG 118:755-62. 2011
    ....
  78. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
    ..Disturbed remodeling is associated with maintenance of high uteroplacental vascular resistance and intrauterine growth restriction (IUGR) and preeclampsia...
  79. ncbi Small artery remodelling in hypertension: causes, consequences and therapeutic implications
    Michael J Mulvany
    Department of Pharmacology, University of Aarhus, University Park 240, 8000 Aarhus C, Denmark
    Med Biol Eng Comput 46:461-7. 2008
    ..The review concludes that there is reasonably strong evidence that a treatment which reduces peripheral resistance in the individual patient will, apart from reducing blood pressure, also improve the abnormal structure...
  80. ncbi Flow-induced remodeling in resistance arteries from obese Zucker rats is associated with endothelial dysfunction
    Celine Bouvet
    Institut National de la Santé et de la Recherche U771, UMR Centre National de la Recherche Scientifique 6214, Universite d Angers, Angers, France
    Hypertension 50:248-54. 2007
    ..This dysfunction might have negative consequences in ischemic diseases in patients with obesity or metabolic syndrome...
  81. ncbi Novel method of quantifying pulmonary vascular resistance by use of simultaneous invasive pressure monitoring and phase-contrast magnetic resonance flow
    Vivek Muthurangu
    Cardiac MR Research Group, Division of Imaging Sciences, King s College, London, United Kingdom
    Circulation 110:826-34. 2004
    Pulmonary vascular resistance (PVR) quantification is important in the treatment of children with pulmonary hypertension. The Fick principle, used to quantify pulmonary artery flow, may be a flawed technique...
  82. ncbi Impaired elastic properties of the ascending aorta in newborns before and early after successful coarctation repair: proof of a systemic vascular disease of the prestenotic arteries?
    Manfred Vogt
    Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Munchen, Technische Universitat, Munich, Germany
    Circulation 111:3269-73. 2005
    ..To find out whether these abnormalities are primarily present or develop later, we studied 17 newborns before and early after surgical repair...
  83. ncbi Aortic distensibility is reduced in subjects with type 2 diabetes and cardiac autonomic neuropathy
    N Tentolouris
    Athens University Medical School, Laiko Hospital, Athens, Greece
    Eur J Clin Invest 33:1075-83. 2003
    ..Cardiac autonomic neuropathy is common in subjects with diabetes. However, the relationship between the elastic properties of the aorta and autonomic neuropathy has not been studied to date in subjects with type 2 diabetes...
  84. ncbi The relationship between the photoplethysmographic waveform and systemic vascular resistance
    Aymen A Awad
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208051, New Haven, CT 06520 8051, USA
    J Clin Monit Comput 21:365-72. 2007
    The objective of this study was to determine the relationship between systemic vascular resistance (SVR), finger & ear photoplethysmographic measurements in 14 adult patients undergoing coronary artery bypass grafting (CABG).
  85. ncbi Antepartum continuous epidural ropivacaine therapy reduces uterine artery vascular resistance in pre-eclampsia: a randomized, dose-ranging, placebo-controlled study
    Y Ginosar
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, PO Box 12000, Ein Kerem, Jerusalem 91120, Israel
    Br J Anaesth 102:369-78. 2009
    ..We hypothesized that sympathectomy induced by epidural local anaesthesia reduces uterine vascular resistance (which is inversely correlated with UPBF) in pre-eclampsia.
  86. ncbi Individual differences in cognitive reappraisal: experiential and physiological responses to an anger provocation
    Iris B Mauss
    Department of Psychology, University of Denver, 2155 South Race Street, Denver, CO 80208, USA
    Int J Psychophysiol 66:116-24. 2007
    ..These findings suggest that reappraisers are successful at down-regulating negative emotions, even in the context of a potent negative emotion such as anger...
  87. ncbi Hemodynamic adaptation during pregnancy in chronic hypertension
    Kati Tihtonen
    Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland
    Hypertens Pregnancy 26:315-28. 2007
    ..To assess hemodynamic and NT-proANP changes in women with chronic hypertension during pregnancy...
  88. ncbi Carotid artery intima-media thickness, but not coronary artery calcium, predicts coronary vascular resistance in patients evaluated for coronary artery disease
    Ibrahim Danad
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur Heart J Cardiovasc Imaging 13:317-23. 2012
    ..An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal coronary vascular resistance (CVR).
  89. ncbi Flap valved closure of ventricular septal defects with increased pulmonary vascular resistance
    Prasanna Simha Mohan Rao
    Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bannerghatta Road, Bangalore, India
    Interact Cardiovasc Thorac Surg 11:577-80. 2010
    Closure of ventricular septal defect (VSD) in children with elevated pulmonary vascular resistance (PVR) is associated with significant morbidity and mortality with pulmonary hypertensive (PH) episodes being a major postoperative problem...
  90. pmc Nanomolar ouabain increases NCX1 expression and enhances Ca2+ signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?
    Cristina I Linde
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 303:H784-94. 2012
    ..These ouabain/endogenous ouabain-modulated mechanisms underlie the whole body autoregulation associated with increased vascular resistance and elevation of BP in human, salt-sensitive hypertension.
  91. ncbi Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine
    Odile Dumont
    Faculte de Medecine, CNRS UMR 6214, Angers 49045, France
    Cardiovasc Res 77:600-8. 2008
    ..In addition, we tested the capacity of a vasodilator treatment with hydralazine to restore remodelling, as we have previously shown that hydralazine has a potent effect on the process...
  92. ncbi Total vascular resistance and left ventricular morphology as screening tools for complications in pregnancy
    Barbara Vasapollo
    Department of Obstetric and Gynecology, Tor Vergata University, Rome, Italy
    Hypertension 51:1020-6. 2008
    We evaluated the predictive value of elevated total vascular resistance on the outcome of pregnancy in normotensive high-risk primigravidas with bilateral notching of the uterine artery Doppler...
  93. ncbi Chronic angiotensin II receptor blockade reduces (intra)renal vascular resistance in patients with type 2 diabetes
    Danilo Fliser
    Department of Internal Medicine, Medical School Hannover, Germany
    J Am Soc Nephrol 16:1135-40. 2005
    ..05) with olmesartan treatment. Chronic angiotensin II subtype 1 receptor blockade decreases (intra)renal vascular resistance and increases renal perfusion despite significant BP reduction...
  94. ncbi Angiogenic and fibrinolytic factors in blood during the first half of pregnancy and adverse pregnancy outcomes
    Marianne Coolman
    Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Obstet Gynecol 119:1190-200. 2012
    ..To estimate whether the imbalance of angiogenic factors (soluble fms-like tyrosine kinase-1, placental growth factor) and fibrinolytic factors (plasminogen activator inhibitor-2 [PAI-2]) might affect placentation in early pregnancy...
  95. ncbi Effects of gastric distension and feeding on cardiovascular variables in the shorthorn sculpin (Myoxocephalus scorpius)
    Henrik Seth
    Dept of Zoology, Univ of Gothenburg, Box 463, S 405 30 Gothenburg, Sweden
    Am J Physiol Regul Integr Comp Physiol 296:R171-7. 2009
    ..is a profound and long-lasting increase in systemic (123 +/- 27%) and gastrointestinal (R(cma); 82 +/- 24%) vascular resistance, leading to an increase in P(da) (19%) without any change in CO or Q(cma)...
  96. ncbi Patterns of postoperative systemic vascular resistance in a randomized trial of conventional on-pump versus off-pump coronary artery bypass graft surgery
    James Tatoulis
    Department of Cardiothoracic Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Ann Thorac Surg 82:1436-44. 2006
    ..We studied systemic vascular resistance (SVR) as a physiologic response to systemic inflammatory response to determine any differences between ..
  97. ncbi Prospective evaluation of the alterations in the morphology and vascular resistance of the renal parenchyma with color Doppler ultrasonography after percutaneous nephrolithotomy
    Suleyman Kilic
    Department of Urology, Turgut Ozal Medical Center, Inonu University School of Medicine, Malatya, Turkey
    J Endourol 22:615-21. 2008
    ..To evaluate the kidneys with color Doppler ultrasonography (CDUS) to determine whether percutaneous nephrolithotomy (PNL) causes renal parenchymal damage...
  98. ncbi Global end-diastolic volume as an indicator of cardiac preload in patients with septic shock
    Frederic Michard
    Medical Intensive Care Unit, Bicetre Hospital, University Paris XI, France
    Chest 124:1900-8. 2003
    ..To assess the value of the global end-diastolic volume (GEDV) evaluated by transpulmonary thermodilution as an indicator of cardiac preload...
  99. ncbi Valsartan reduces serum cystatin C and the renal vascular resistance in patients with essential hypertension
    Sanae Watanabe
    The Second Department of Internal Medicine, Ehime University School of Medicine, Toon City, Ehime, Japan
    Clin Exp Hypertens 28:451-61. 2006
    A high level of albuminuria and increased renal vascular resistance are associated with hypertensive renal damage...
  100. ncbi Fingertip photoplethysmographic waveform variability and systemic vascular resistance in intensive care unit patients
    Paul M Middleton
    Ambulance Research Institute, Ambulance Service of New South Wales, Sydney, NSW 2039, Australia
    Med Biol Eng Comput 49:859-66. 2011
    ..In this study, we examined the association between fingertip PPG waveform variability (PPGV) and systemic vascular resistance (SVR) obtained from thermodilution cardiac output (CO) and intra-arterial pressure measurements in 48 post ..
  101. ncbi Angiotensin II contributes to the increased baseline leg vascular resistance in spinal cord-injured individuals
    Jan T Groothuis
    aDepartment of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Hypertens 28:2094-101. 2010
    Spinal cord-injured (SCI) individuals demonstrate an increased baseline leg vascular resistance (LVR). In addition, despite the lack of sympathetic control, an increase in LVR is observed during orthostatic challenges...

Research Grants72

  1. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..at 3 different reperfusion times (1, 3, 6 h) for wet/dry weight ratio, graft oxygenation, pulmonary vascular resistance, dynamic compliance, and lung F2[unreadable]-isoprostane, histology, and immunohistochemistry for 3-..
  2. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..wet/dy weight ratio (W/D) (a measure of pulmonary edema), b) oxygenation by the graft, c) graft pulmonary vascular resistance, d) dynamic compliance, and e) lung tissue analysis for F2[unreadable]-isoprostane (a measure of lipid ..
  3. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..Aim #1: determine blood pressure (BP)(cuff and ambulatory 24 hour), arterial stiffness (AS), peripheral vascular resistance(PVR) and nitric oxide (NO)production and their relation to circulating levels of 25-OH vitamin D (25-OH D) ..
  4. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..while considered a physiologically relevant and important regulator of arterial pressure, blood flow and vascular resistance, is thought to contribute to pathology, if overactive...
  5. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..PAR") formation;2) Improved hemodynamics and airway pressures, as revealed by reductions in pulmonary vascular resistance (PVR), mean pulmonary arterial pressure (MPAP), and peak inspiratory pressure (PIP), without impacting ..
  6. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..status, compliance and surfactant production and release) or instrumented for evaluation of pulmonary vascular resistance, oxygenation and ventilation for 6 h...
  7. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..least moderate pulmonary hypertension (PH) (mean pulmonary artery pressure [mPAP] >30 mm Hg, pulmonary vascular resistance [PVR]>3...
  8. Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    Istvan Seri; Fiscal Year: 2013
    ..by applicant): Cardiac output (CO) and measures of cardiac preload (central blood volume, CBV) and systemic vascular resistance (SVR) are critical clinical parameters of circulatory function...
  9. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2012
    ..Inhaled NO therapy enhances alveolar and vascular growth and lowers pulmonary vascular resistance in animal models of BPD, further suggesting that reduced NO production or bioavailability may contribute to ..
  10. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..provided by applicant): Persistent pulmonary hypertension of the newborn (PPHN) occurs when the pulmonary vascular resistance fails to decrease at birth...
  11. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..vascular obstruction and variable presence of vasoconstriction, leading to a sustained increased pulmonary vascular resistance, vascular remodeling, right ventricular (RV) failure, and low cardiac output...
  12. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Despite the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure ..
  13. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..are considered to play a key role in vascular remodeling that lead to increased pulmonary vascular resistance associated with PAH...
  14. Bifunctional Redox Agent for the Treatment of PPHN
    GARRY JOHN SOUTHAN; Fiscal Year: 2011
    ..of the newborn (PPHN) is a life-threatening neonatal condition wherein an elevation in pulmonary vascular resistance after birth diverts pulmonary blood flow via a right-to-left shunt, at the levels of the ductus arteriosus ..
  15. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Additionally, the effects of oral L-arginine on glomerular filtration rate, cardiac output, systemic vascular resistance, endothelial function, plasma arginine level and urinary cyclic-GMP will be assessed (Aim 2)...
  16. Free Hemoglobin Potentiates Pulmonary Vascular Dysfunction in Acute Lung Injury
    JULIE ANNE BASTARACHE; Fiscal Year: 2013
    ..hemoglobin levels and pulmonary vascular dysfunction (as measured by pulmonary artery pressure, pulmonary vascular resistance, transpulmonary resistance), cardiac dysfunction (as measured by cardiac output and mixed venous oxygen ..
  17. Inflammation and Injury in Obesity Hypertension in African American Adolescents
    Bonita Falkner; Fiscal Year: 2010
    ..3) if the OHBP phenotype has evidence of CV injury, ascertained by left ventricular mass index, peripheral vascular resistance, and UAE. The contribution of genetic variants in adipokine regulatory genes will be examined...
  18. Blood Pressure Regulation: Novel Roles for the Kidney
    Pablo A Ortiz; Fiscal Year: 2013
    ..occurs via integration of the actions of prch and anti-hypertensive agents on nephron transport, renal vascular resistance, release of renal hormones and cross-talk between epithelial and vascular cells...
  19. Omega-3 Fatty Acids, Neurohumoral Activation, and Human Heart Failure
    Kevin D Monahan; Fiscal Year: 2010
    ..It is expected that neurohumoral activation and vascular resistance at rest will be reduced and abnormalities in baroreflex control of the circulation including modulation of ..
  20. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2013
    ..change in BP;2) Stress Reactivity - based on a composite score involving cardiovascular (blood pressure and vascular resistance), neuroendocrine (cortisol), and inflammatory (IL-6) responses to the Trier Social Stress Test;3) ..
  21. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2012
    ..provided by applicant): Pulmonary arterial hypertension (PAH) is characterized by an increase in pulmonary vascular resistance that impedes ejection of blood by the right ventricle, leading to right ventricular failure...
  22. Ouabain, Na+ Pumps, and Ca2+ Signaling in Human Arteries
    Laura K Antos; Fiscal Year: 2010
    ..This in turn raises vascular tone and peripheral vascular resistance, and thereby elevates BP. Parallels of the rodent mechanism can be seen in humans...
  23. Role of Endothelin B Receptor in Vascular Protection in Females
    Raouf A Khalil; Fiscal Year: 2011
    ..the vascular protective mechanisms of endothelin B receptors in females, and would shed light on the pathophysiological basis of the increased vascular resistance and hypertension associated with estrogen deficiency in menopausal women.
  24. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ..glutamate at position 27 (Glu27) (haplotype 1) will demonstrate greater cardiac output and lower systemic vascular resistance during mental stress and isometric handgrip exercise than individuals with haplotypes homozygous for ..
  25. Role of Acid-Sensing Ion Channels in Pulmonary Vascular Smooth Muscle Store-Opera
    Nikki L Jernigan; Fiscal Year: 2012
    ..it will provide new insights into the mechanism of SOCE as a foundation for the regulation of pulmonary vascular resistance, which is altered in disease states such as chronic obstructive pulmonary disease (COPD) and sleep apnea...
  26. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    ..Acute PE also causes vasoconstriction that increases pulmonary vascular resistance (PVR)...
  27. Rho-kinase signaling in lung development and persistent pulmonary hypertension
    Jason Gien; Fiscal Year: 2013
    ..PPHN is a clinical syndrome characterized by increased pulmonary vascular resistance (PVR), which prevents the transition from fetal to extrauterine life...
  28. Low birth weight, the kidney, and hypertension
    Barbara T Alexander; Fiscal Year: 2013
    ..Thus, we hypothesize that testosterone increases renal vascular resistance and exacerbates hypertension in male IUGR by enhancing the endothelin system, thus leading to increased ..
  29. Environmental Toxicants, Race, and Cardiovascular Disease Risk in Children
    Brooks B Gump; Fiscal Year: 2013
    ..co-inhibition" of both sympathetic and parasympathetic activity that is typically associated with greater vascular resistance, a cardiovascular pattern we had already observed in children with heightened early childhood blood Pb (..
  30. The Role of T Lymphocytes in Hypertension During Chronic Inflammatory Disease
    KEISA WILLIAMS MATHIS; Fiscal Year: 2013
    ..there is a rightward parallel shift in the chronic pressure natriuresis relationship and increased renal vascular resistance and renal vascular sensitivity to angiotensin II (AngII) suggesting that inflammation contributes to SLE ..
  31. Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary Dysplasia
    Aaron Hamvas; Fiscal Year: 2013
    ..and postnatal lung inflammation contribute to structural airway simplification and increased pulmonary vascular resistance, critical components of BPD...
  32. Agonistic Stress and CVD Risk in Young Adults
    Craig K Ewart; Fiscal Year: 2010
    ..1987-1999) have shown that youths at high CVD risk who exhibit agonistic (AG) behavior and increased vascular resistance under a structured social challenge have elevated ambulatory blood pressure (ABP) in the natural ..
  33. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..The adequacy of the baroreflex response is a function of central baroreceptor sensitivity and peripheral vascular resistance. While a number of studies have indicated that estradiol and progesterone impact aspects of the orthostatic ..
  34. Perinatal regulation of endothelial NOS
    Stephen M Black; Fiscal Year: 2010
    ..In fact, post-operatively the dynamic changes in vascular resistance can lead to significant morbidity and mortality, and much of our therapies are focused on altering ..
  35. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2013
    ..Based on these observations we formulated the central hypothesis that vascular resistance and thus, systemic blood pressure control is mediated through a localized NAMPT-regulated GSNOR mechanism...
  36. Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel Wall
    ADAM CARL STRAUB; Fiscal Year: 2012
    ..Based on these observations we formulated the central hypothesis that vascular resistance and thus, systemic blood pressure control is mediated through a localized NAMPT-regulated GSNOR mechanism...
  37. Vasomotor Sympathetic Activity during Early Pregnancy in Humans
    Qi Fu; Fiscal Year: 2010
    ..to those of congestive heart failure patients), while paradoxically their blood pressure and peripheral vascular resistance were normal...
  38. Lead and Vascular Reactivity to Acute Stress in Children
    Brooks Gump; Fiscal Year: 2009
    ..For example, studies with animals have shown lead-induced increases in vascular resistance. We recently demonstrated that 9 1/2 year old children with higher early childhood lead levels were ..
  39. HIV/Cocaine mediated human pulmonary vascular remodeling: Role of BMPR signaling.
    Navneet Kaur Dhillon; Fiscal Year: 2013
    ..are considered to play a key role in vascular remodeling leading to increased pulmonary vascular resistance associated with PAH but the mechanisms and pathogenesis involved remain elusive...
  40. Vascular Smooth Muscle Function in Pulmonary Hypertension
    Nikki L Jernigan; Fiscal Year: 2013
    ..smooth muscle cell (PASMC) intracellular calcium ([Ca2+]i) plays a vital role in establishing pulmonary vascular resistance and it has become increasingly evident that increased Ca2+ influx contributes to both the vasoconstrictor ..
  41. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2013
    ..diameter of muscular arteries and arterioles of the microcirculation is the principal site of control of vascular resistance. These small blood vessels are significant regulators of blood pressure and local blood flow distribution, ..
  42. Mitochondria-Derived Reactive Oxygen Species and Nox4 in Pulmonary Hypertension
    SHERRY ADESINA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pulmonary Hypertension (PH) is characterized by increased pulmonary vascular resistance, pulmonary vascular remodeling, and increases in blood pressure that often results in right ventricular ..
  43. OXIDATIVE STRESS AND KIDNEY OXYGEN USAGE
    William J Welch; Fiscal Year: 2012
    ..and enhancement of tubuloglomerular feedback, leading to decreased renal blood flow and increased renal vascular resistance. These studies should provide new and valuable information on the relationship between oxygen usage in the ..
  44. Effect of Spironolactone of Collagen Synthesis in Pulmonary Arterial Hypertension
    Zeenat Safdar; Fiscal Year: 2013
    ..be present compared to age- and gender-matched controls;second, these levels will correlate with pulmonary vascular resistance and circulating levels of aldos- terone...
  45. Calcium and Sodium Transport in Hypertension
    John M Hamlyn; Fiscal Year: 2012
    ..blood pressure (BP) which, in the chronic state (hypertension), is sustained by increased total peripheral vascular resistance (TPR). Surprisingly, the "signaling pathway" by which salt retention increases TPR and BP is unresolved...
  46. Heart Vascular Function and Thyroid Hormone Receptors
    Wolfgang H Dillmann; Fiscal Year: 2013
    ..undesirable effects like increases in heart rate, oxygen consumption, or a significant decrease in systemic vascular resistance. In Aim II we determine the effects of EC-based TR1 and TR2 expression or deletion on cardiac capillary ..
  47. Role of 15-lipoxygenase in Enhanced Pulmonary Vasoconstriction in Females
    Sandra L Pfister; Fiscal Year: 2010
    ..hypertension encompasses a group of diseases characterized by high pulmonary artery pressure and pulmonary vascular resistance. Vasoconstriction, vascular remodeling and thrombosis all contribute to the increased vascular resistance...
  48. Right Ventricular-Pulmonary Vascular Interactions in Pulmonary Hypertension
    Naomi C Chesler; Fiscal Year: 2013
    ..Aim 2. To quantify the effects of exercise on pulmonary arterial stiffness, pulmonary vascular resistance, right ventricular function and the efficiency of ventricular-vascular interactions in patients with PAH...
  49. ACE2 Deficiency: A new model of maternal and fetal growth restriction.
    Liliya M Yamaleyeva; Fiscal Year: 2013
    ..High uteroplacental vascular resistance is thought to be associated wit FGR...
  50. Prostacyclin-secreting Cells as Therapy for Pulmonary Artery Hypertension
    Ke He Ruan; Fiscal Year: 2010
    ..Characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, PAH ultimately leads to right heart failure and death...
  51. HEME OXYGENASE REGULATION OF EICOSANOID BIOSYNTHESIS
    Nader G Abraham; Fiscal Year: 2013
    ..The major goal is to determine the optimum conditions for enhanced vascular resistance by focusing on the HO-1-EET module as a critical protective mechanism against injury-mediated vascular ..
  52. Cell-targeted drug delivery for the treatment of pulmonary arterial hypertension
    Masahiko Oka; Fiscal Year: 2012
    ..sustained Rho kinase-mediated pulmonary vasoconstriction is an important component of increased pulmonary vascular resistance in various animal models, as well as in human forms of PAH...
  53. Perinatal Pulmonary Hypertension: Developmental Mediators
    Jeffrey R Fineman; Fiscal Year: 2013
    ..in a lamb model of CHD;(2) To determine the effect of acute IV L-carnitine treatment on pulmonary vascular resistance, vascular reactivity, and myocardial performance following CPB in a lamb model of CHD;(3A) To determine ..
  54. Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients
    Nader Najafi; Fiscal Year: 2013
    ..is largely a passive process, any anatomic obstruction within the pulmonary vasculature, elevated pulmonary vascular resistance, or significant ventricular dysfunction can result in patients having elevated hemi-Fontan pressures...
  55. Protective Effects of Anti-C5a in Sepsis
    Peter A Ward; Fiscal Year: 2013
    ..will employ non-invasive echocardiography approaches to assess systolic and diastolic function and systemic vascular resistance, as well as other parameters, in CLP mice as compared to sham mice...
  56. ANIMAL MODELS FOR STUDYING THE GENETICS OF HYPERTENSION
    Oliver Smithies; Fiscal Year: 2013
    ..test the hypothesis that the soluble factors affect blood pressure (BP) primarily by increasing systemic vascular resistance. Using novel mice in which endothelin1, (ET1), a factor downstream of sFlt1, and/or TGF[unreadable]1 ..
  57. Mechanisms of cGMP-Mediated Vasodilation in Perinatal Lung
    J Usha Raj; Fiscal Year: 2010
    ..and oxygenation, both pulmonary arteries and veins must dilate to facilitate the dramatic fall in pulmonary vascular resistance and the increase in blood flow through the lungs...
  58. Exploring Vasomotor Mechanisms using New PKG Inhibitors and cGMP Biosensors
    Wolfgang R Dostmann; Fiscal Year: 2012
    ..PKG to vascular control in vivo by studying the efficacy of PKG inhibitors to increase blood pressure and vascular resistance in the intact animal...
  59. Calcium entry pathway in hypoxic pulmonary hypertension
    Jian Wang; Fiscal Year: 2010
    ..and CCE caused by acute hypoxia;2) the effects of chronic hypoxia on TRPC expression, CCE and pulmonary vascular resistance;3) whether SOCC antagonists reverse hypoxia-induced changes in baseline [Ca2+]i, CCE and pulmonary vascular ..
  60. Mechanisms of coronary endothelial dysfunction in diabetes
    Ayako Makino; Fiscal Year: 2011
    ..cells to hyperglycemia results in downregulated Cx40 protein expression, which increases coronary vascular resistance, decreases cardiac blood supply and increases mortality in diabetes...
  61. Novel Peptide for Dynamic Regulation of Lung Endothelium NOS/cGMP Functions
    Jawaharlal M Patel; Fiscal Year: 2011
    ..by vascular obstruction and variable presence of vasoconstriction, leading to increased pulmonary vascular resistance and right ventricular failure...
  62. Effects of Arginase in Right Ventricular Hypertrophy and Failure
    S JULIE ANN LLOYD; Fiscal Year: 2012
    The majority of patients with elevated pulmonary vascular resistance die from right ventricular (RV) failure, yet very little is known about this process...
  63. THE EFFECTS OF COCAINE ON FETAL OXYGENATION
    James Woods; Fiscal Year: 1993
    ..probe for measurement of maternal heart rate, blood pressure, cardiac output and calculation of systemic vascular resistance. In a second surgery ten days later, flow probes will be secured for maternal femoral and uterine blood ..
  64. Tumor NMR Images are Affected by Anesthetic
    Natarajan Raghunand; Fiscal Year: 2006
    ..Therefore, systemic effects on cardiac output, blood pressure and systemic vascular resistance will have profound effects upon tumor perfusion...
  65. PERINATAL PULMONARY CIRCULATION--VASOACTIVE MEDIATORS
    Michael Heymann; Fiscal Year: 1999
    ..ventilation at birth, pulmonary blood flow (PBF) increases 8- 10-fold with a concomitant fall in pulmonary vascular resistance. Although recent physiological advances have highlighted the role of the vascular endothelium in ..
  66. COMPLEMENT-DEPENDENT PROSTAGLANDIN SYNTHESIS IN SEPSIS
    Mitchell Fink; Fiscal Year: 1991
    Although low systemic vascular resistance is a consistent hemodynamic feature of sepsis in humans, relatively little is known about the mechanisms involved...
  67. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    ..that occur during pregnancy include chronic increases in cardiac output, falls in total peripheral vascular resistance and tachycardia...
  68. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2010
    ..This placental dysfunction manifests as an increase in placental vascular resistance, deterioration in fetal gas exchange, and redistribution of fetal circulation...
  69. DETERMINANTS OF SODIUM RETENTION IN CIRRHOSIS
    WILLIAM RECTOR; Fiscal Year: 1992
    ..Total blood volume (BV) is not reduced in such patients, but mean arterial pressue (MAP) and systemic vascular resistance (SVR) are often low, suggesting that "effective" arterial underfilling may be present...
  70. PARS inhibitor therapy of smoke inhalation injury
    Prakash Jagtap; Fiscal Year: 2001
    ..v.). The percent change from baseline pulmonary vascular resistance, systemic vascular resistance, cardiac output, and PaO2/FiO2 ratio will be compared to untreated controls...
  71. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    ..leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  72. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..heart disease) the initial injury leading to vasoconstriction, vascular remodeling, and increased pulmonary vascular resistance is unknown...