Genomes and Genes
Summary: Biological actions and events that support the functions involved in systemic or regional BLOOD CIRCULATION.
Publications192 found, 100 shown here
- Norepinephrine and vital organ blood flowDavid Di Giantomasso
Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Intensive Care Med 28:1804-9. 2002..To test whether norepinephrine (NE) infusion at 0.4 microg kg(-1) min(-1) adversely affects regional blood flow in the normal mammalian circulation...
- Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjectsAnand Kumar
Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
Crit Care Med 32:691-9. 2004....
- Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxideRyon M Bateman
Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
Crit Care 7:359-73. 2003..NO also regulates mitochondrial respiration. During sepsis, NO over-production mediates systemic hypotension and microvascular reactivity, and is seemingly protective of microvascular blood flow...
- Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shockYasser Sakr
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
Crit Care Med 32:1825-31. 2004..To characterize the time course of microcirculatory alterations and their relation to outcome in patients with septic shock...
- Intradialytic hypotension: an overview of recent, unresolved and overlooked issuesRichard A Sherman
Semin Dial 15:141-3. 2002..While many risk factors have been identified, the issues of sodium and thermal balance and variability in left ventricular filling have not been adequately emphasized or investigated...
- A numerical study of blood flow in coronary artery bypass graft side-to-side anastomosesMichael Bonert
Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
Ann Biomed Eng 30:599-611. 2002..We studied hemodynamics in idealized models of "parallel" and "diamond" side-to-side anastomoses, identifying features that might promote restenosis...
- Effect of desflurane-induced preconditioning following ischemia-reperfusion on nitric oxide release in rabbitsShen Kou Tsai
Department of Anesthesiology, College of Medicine, National Yang Ming University and National Taiwan University, Taipei Veterans General Hospital, 201, Shih Pai Road, Second, Taipei, Taiwan
Life Sci 76:651-60. 2004..This beneficial effect of desflurane on the ischemic preconditioning is probably through NO release since L-NAME abrogates the desflurane preconditioning effect...
- An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injuryMichael Quintel
Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum, Mannheim, Mannheim, Germany
Am J Respir Crit Care Med 169:534-41. 2004..We conclude that in OA-injured lung, the increase of IAP increases the amount of edema...
- Renal blood flow in sepsisChristoph Langenberg
Department of Intensive Care, Austin Hospital, and University of Melbourne, Heidelberg, Melbourne, Australia
Crit Care 9:R363-74. 2005..To assess changes in renal blood flow (RBF) in human and experimental sepsis, and to identify determinants of RBF...
- Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injuryAntoine Roch
Service de Reanimation Polyvalente, hopitaux Sud, Marseille, France
Crit Care Med 32:811-7. 2004....
- Practice parameters for hemodynamic support of sepsis in adult patients: 2004 updateSteven M Hollenberg
Crit Care Med 32:1928-48. 2004..To provide the American College of Critical Care Medicine with updated guidelines for hemodynamic support of adult patients with sepsis...
- Comparative effects of vasopressin, norepinephrine, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in endotoxic shockBruno Levy
Groupe de Recherche en Physiopathologie Respiratoire, Institut de Pharmacologie, Universite de Sherbrooke, Quebec, Canada J1H 5N4
Am J Physiol Heart Circ Physiol 287:H209-15. 2004..These results suggest that, in a short-term endotoxic shock model, AVP improves systemic hemodynamics without side effects and has particular beneficial effects on renal function...
- Endocrinologic response to vasopressin infusion in advanced vasodilatory shockMartin W Dunser
Division of General and Surgical Intensive Care Medicine, Department of Anesthesiology and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Innsbruck, Austria
Crit Care Med 32:1266-71. 2004....
- Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channelsEric Dubuis
LABPART, Faculte de Medecine, 2 bis Boulevard Tonnelle, 37032 Tours, France
Cardiovasc Res 65:751-61. 2005....
- Impact of high volume hemofiltration on hemodynamic disturbance and outcome during septic shockOlivier Joannes-Boyau
Department of Anesthesiology and Critical Care II, University of Bordeaux, Pessac, France
ASAIO J 50:102-9. 2004..This study suggests a beneficial effect of HVCVVH on 28 day mortality (46% vs. 70%), and further studies with larger cohorts are required...
- Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsisChristopher G Ellis
Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8, Canada
Am J Physiol Heart Circ Physiol 282:H156-64. 2002..Capillary O(2) extraction increased threefold (P < 0.05) and was directly related to the degree of stopped flow in the EDL. Thus impaired O(2) transport in early stage sepsis is likely the result of a microcirculatory dysfunction...
- Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemiaAntje Pittner
Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
Intensive Care Med 29:312-6. 2003..To determine the mechanisms of improved gut mucosal acidosis associated with selective inducible nitric oxide synthase (iNOS) inhibition...
- Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitisSambit Sen
Liver Failure Group, Institute of Hepatology, University College London Medical School, 69 75 Chenies Mews, London WC1E 6HX, UK
J Hepatol 43:142-8. 2005..This study evaluates the acute effects of albumin dialysis, using the Molecular Adsorbents Recirculating System (MARS), on portal pressure in AH...
- Prone positioning, systemic hemodynamics, hepatic indocyanine green kinetics, and gastric intramucosal energy balance in patients with acute lung injuryRudolf Hering
Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Intensive Care Med 28:53-8. 2002..To investigate the effects of prone positioning on systemic hemodynamics, intra-abdominal pressure (IAP), plasma disappearance rate of indocyanine green (PDR(ICG)), and gastric intramucosal to arterial PCO2 difference (Pi-aCO2)...
- High-dose vasopressin is not superior to norepinephrine in septic shockStefan Klinzing
Department of Anesthesiology and Intensive Care Medicine, Freidrich Schiller University, Jena, Germany
Crit Care Med 31:2646-50. 2003..We examined the effects of arginine vasopressin, when substituted for norepinephrine as a vasopressor in septic shock, on global and hepatosplanchnic hemodynamic and oxygen transport variables...
- Myocardial dysfunction in the patient with sepsisSreenandh Krishnagopalan
Section of Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
Curr Opin Crit Care 8:376-88. 2002..In addition, septic myocardial depression appears to be mediated in part through combinations of nitric oxide-dependent and -independent alterations of basal and catecholamine-stimulated cardiac myocyte contractility...
- Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horsesStina Marntell
Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
Vet Anaesth Analg 32:83-93. 2005..To study pulmonary gas exchange and cardiovascular responses to sedation achieved with romifidine and butorphanol (RB) alone, or combined with acepromazine, and during subsequent tiletamine-zolazepam anaesthesia in horses...
- Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patientsDaniel A Reuter
Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Intensive Care Med 29:476-80. 2003..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
- Effect of prone position on hepato-splanchnic hemodynamics in acute lung injuryMartin Matejovic
Intensive Care Unit, 1st Medical Department, Charles University Hospital Plzen, Alej Svobody 80, 304 60 Plzen, Czech Republic
Intensive Care Med 28:1750-5. 2002..To evaluate the effects of prone position on hepato-splanchnic hemodynamics, metabolism and gut mucosal energy balance...
- Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patientsThierry Boulain
Service de Reanimation Medicale, Hopital de Bicetre, Faculte de Medecine Paris Sud, Paris, France
Chest 121:1245-52. 2002....
- Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shockAnthony Chin
Divisions of Pediatric Surgery, Department of Surgery and Pediatrics, The University of Illinois College of Medicine at Chicago, Chicago, IL, USA
J Pediatr Surg 37:482-7. 2002..In this study the authors have examined the effects of tezosentan, a dual endothelin-receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxemia...
- Opening the microcirculation: can vasodilators be useful in sepsis?Mattijn Buwalda
Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Intensive Care Med 28:1208-17. 2002....
- Intrarenal blood flow distribution in hyperdynamic septic shock: Effect of norepinephrineDavid Di Giantomasso
Department of Medicine, Melbourne University Austin and Repatriation Medical Centre, Heidelberg, Australia
Crit Care Med 31:2509-13. 2003..To measure changes in medullary and cortical renal blood flow during experimental hyperdynamic sepsis and the effect of subsequent norepinephrine infusion on such flows. DESIGN Experimental animal study...
- Hepatic and systemic haemodynamic changes after MARS in patients with acute on chronic liver failureMaria Vega Catalina
Hepatic Hemodynamic Unit, Department of Hepatology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
Liver Int 23:39-43. 2003..01). MARS decreases portal hypertension and ameliorates hyperdynamic circulation in patients with AoCLF, probably mediated by clearance of vasoactive substances. Further studies are necessary to confirm these results...
- Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategySalvatore Grasso
Servizio di Anestesiologia e Rianimazione, Ospedale Di Venere, Bari, Italy
Anesthesiology 96:795-802. 2002..This study examined the hypothesis that the effectiveness of a recruiting maneuver to improve oxygenation in patients with ARDS would be influenced by the elastic properties of the lung and chest wall...
- Effects of end-inspiratory and end-expiratory pressures on alveolar recruitment and derecruitment in saline-washout-induced lung injury -- a computed tomography studyT Luecke
Department of Anesthesiology and Intensive Care, University Hospital of Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Germany
Acta Anaesthesiol Scand 48:82-92. 2004....
- Meta-analysis of hemodynamic optimization in high-risk patientsJack W Kern
USC School of Pharmacy, Los Angeles, CA, USA
Crit Care Med 30:1686-92. 2002....
- Clinical review: Hypertonic saline resuscitation in sepsisRoselaine P Oliveira
Department of Critical Care Medicine, Santa Casa Hospital, Federal University of Rio Grande do Sul, Porto Alegra, Brazil
Crit Care 6:418-23. 2002..The goal of research in this field is to identify reliable therapies to prevent ischemia and inflammation, and to reduce mortality...
- [Arginine vasopressin in vasodilatory shock: a new therapy approach?]M Dunser
Klinische Abteilung für Allgemeine und Chirurgische Intensivmedizin, Univ Klinik für Anästhesie und Allgemeine Intensivmedizin Leopold Franzens Universität Innsbruck, Germany
Anaesthesist 51:650-9; discussion 659-60. 2002..Therefore, arginine vasopressin should be restricted to patients where adequate stabilization of hemodynamic function cannot be achieved by conventional vasopressor therapy alone...
- Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled studyMartin W Dunser
Division of General and Surgical Intensive Care Medicine, Department of Anesthesia and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
Circulation 107:2313-9. 2003..Arginine vasopressin (AVP) has recently been shown to be a potent vasopressor agent to stabilize cardiocirculatory function even in patients with catecholamine-resistant vasodilatory shock...
- Norepinephrine and vital organ blood flow during experimental hyperdynamic sepsisDavid Di Giantomasso
Howard Florey Institute, Parkville, Melbourne, Australia
Intensive Care Med 29:1774-81. 2003..To study the effect of norepinephrine (NE) infusion on cerebral, coronary, renal and mesenteric blood flow during sepsis...
- Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shockMiriam M Treggiari
Surgical Intensive Care Division, Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital, Geneva, Switzerland
Crit Care Med 30:1334-9. 2002..To evaluate the effect of a norepinephrine-induced differential increase in mean arterial pressure on splanchnic and renal perfusion in a porcine model of volume-resuscitated endotoxic shock...
- Terlipressin for norepinephrine-resistant septic shockAlastair O'Brien
Lancet 359:1209-10. 2002..Terlipressin seems to be an effective rescue therapy, which is able to restore blood pressure in patients with catecholamine-resistant septic shock, without obvious complication...
- Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograftKazuo Shirakawa
Pharmacology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
Cancer Res 62:560-6. 2002..These facts led us to hypothesize that the VM of WIBC-9 involves hemodynamics that serve to feed WIBC-9 cells, and this in turn suggests a connection between VM and angiogenesis...
- Effects of dopamine on systemic and regional blood flow and metabolism in septic and cardiac surgery patientsStephan M Jakob
Department of Intensive Care Medicine, University Hospital, Bern, Switzerland
Shock 18:8-13. 2002..The safety and indications of dopamine use in sepsis should be re-evaluated...
- Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?Daniel De Backer
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B 1070 Brussels, Belgium
Crit Care Med 31:1659-67. 2003..To assess the effects of different doses of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in patients with septic shock...
- Beneficial effects of short-term vasopressin infusion during severe septic shockBhavesh M Patel
Department of Critical Care, Mayo Clinic Arizona, Scottsdale, Arizona, USA
Anesthesiology 96:576-82. 2002....
- A randomised, controlled trial of the pulmonary artery catheter in critically ill patientsAndrew Rhodes
Department of Intensive Care, St George s Hospital, London SW17 0QT, UK
Intensive Care Med 28:256-64. 2002..To compare the survival and clinical outcomes of critically ill patients treated with the use of a pulmonary artery catheter (PAC) to those treated without the use of a PAC...
- Are hypertonic hyperoncotic solutions safe for prehospital small-volume resuscitation? Results of a prospective observational studyWalter Mauritz
Department of Anaesthesia and Critical Care, Lorenz Böhler Trauma Center, Donaueschingenstrasse 13, A 1200 Vienna, Austria
Eur J Emerg Med 9:315-9. 2002..Effects on homeostasis and haemodynamics as well as safety were evaluated...
- Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic ratsBruno Levy
Réanimation Médicale, Hopital Central, 54035, Nancy Cedex, France
Intensive Care Med 29:292-300. 2003..To determine whether epinephrine increases lactate concentration in sepsis through hypoxia or through a particular thermogenic or metabolic pathway...
- Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: role of adrenomedullin and adrenomedullin binding protein-1Shaolong Yang
Center for Surgical Research and Department of Surgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA
Ann Surg 236:625-33. 2002..To determine whether the combined administration of adrenomedullin and adrenomedullin binding protein-1 (AM/AMBP-1) has any modulatory effects on the cardiovascular response during the progression of sepsis...
- Haemodynamic monitoring with pulse-induced contour cardiac output (PiCCO) in critical careRos Cottis
Critical Care Unit, Southend Hospital, Prittlewell Chase, Southend on Sea, Essex, UK
Intensive Crit Care Nurs 19:301-7. 2003..These parameters are of interest as they are considered to be the most specific measures of cardiac preload, pulmonary oedema and contractility and a global indicator of cardiac performance...
- Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategiesMartial G Bourassa
Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada, H1T 1C8
J Am Coll Cardiol 41:351-9. 2003..Successful medical, interventional, or surgical therapy leads not only to marked improvement or normalization of these alterations but also relief of angina and ischemia...
- Cardiovascular effects of romifidine in the standing horseS L Freeman
Department of Farm Animal and Equine Medicine and Surgery, Royal Veterinary College, Hawkshead Lane, N Mymms, Hatfield, Herts, AL9 7TA, UK
Res Vet Sci 72:123-9. 2002..There were minimal differences between the two doses of romifidine, and both should be used with care especially in horses with cardiovascular compromise, or when used in combination with other cardiovascular depressant drugs...
- Randomised controlled trial investigating the influence of intravenous fluid titration using oesophageal Doppler monitoring during bowel surgeryD H Conway
Department of Anaesthesia, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
Anaesthesia 57:845-9. 2002..003). Five control patients required postoperative critical care admission. Fluid titration using oesophageal Doppler during bowel surgery can improve haemodynamic parameters and may reduce critical care admissions postoperatively...
- Effects of norepinephrine, epinephrine, and norepinephrine-dobutamine on systemic and gastric mucosal oxygenation in septic shockShao Xia Zhou
Department of Critical Care Medicine, Zhong Da Hospital and School of Clinical Medicine, Southeast University, Nanjing 210009, China
Acta Pharmacol Sin 23:654-8. 2002..To compare the effects of dopamine, norepinephrine, epinephrine, and the combination of norepinephrine and dobutamine on systemic and gastric mucosal oxygen metabolism in patients with septic shock...
- Review article: volume expansion in patients with cirrhosisJ H Henriksen
Department of linical Physiology 239, Hvidovre Hospital, University of Copenhagen, Denmark
Aliment Pharmacol Ther 16:12-23. 2002..Timely handling is essential, but difficult as it is a balance between the risks of excess extravascular volume loading and further circulatory dysfunction in these patients with a hyperdynamic, but hyporeactive, circulation...
- Positive pressure mechanical ventilationBhargavi Gali
Department of Anesthesiology and Critical Care, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Emerg Med Clin North Am 21:453-73. 2003..The role of specific modes and parameters of these devices likely will be further refined to maximize outcomes...
- What is the optimal duration of ventilation in the prone position in acute lung injury and acute respiratory distress syndrome?D F McAuley
Intensive Care Unit, Birmingham Heartlands Teaching Hospital, Bordesley Green East, Birmingham B9 5SS, UK
Intensive Care Med 28:414-8. 2002....
- Impact of perioperative haemodynamic monitoring on cardiac morbidity after major vascular surgery in low risk patients. A randomised pilot trialM Bonazzi
Department of Anesthesia and Intensive Care Unit, Bassini Hospital, via M Gorki 50, 20092 Cinisello Balsamo, Milan, Italy
Eur J Vasc Endovasc Surg 23:445-51. 2002..to evaluate whether perioperative haemodynamic optimisation influences outcome from infrarenal abdominal aortic aneurysm repair...
- Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shockVladimir Krejci
Department of Anesthesiology, Inselspital, University Hospital of Berne, Switzerland
Crit Care Med 31:203-10. 2003..The aim of this investigation was to study the effects of an endothelin antagonist on microcirculatory blood flow in multiple abdominal organs during septic shock...
- Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shockJean Charles Preiser
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
Shock 20:465-8. 2003..In the presence of endotoxin, ODQ administration increased MBF and prevented the restoration of FBF. Hence, selective inhibition of sGC may increase splanchnic blood flow in septic shock...
- Sublingual capnometry versus traditional markers of tissue oxygenation in critically ill patientsPaul E Marik
Department of Critical Care Medicine, Mercy Hospital of Pittsburgh, PA, USA
Crit Care Med 31:818-22. 2003....
- The changes of hepatic sinusoidal microcirculation and effects of nitric oxide synthase inhibitor during sepsisTsann Long Hwang
Department of Surgery, Chang Gung Memorial Hospital 199, Tung Hwa N Rd, Taipei, Taiwan
Hepatogastroenterology 50:213-6. 2003..The changes in hepatic microcirculation corresponding to liver functions and the effects of nitric oxide synthase inhibitor on the liver during sepsis were studied...
- Estimation of choroid perfusion by colour Doppler imaging vs. other methodsOliver Zeitz
Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Augenheilkunde, Hamburg, Germany
Ultrasound Med Biol 28:1023-7. 2002..50; p = 0.005; n = 30) and long posterior ciliary arteries (r = 0.41; p = 0.024; n = 30). Methods strengthened each other by partial correlation. The study demonstrates that CDI allows a more detailed insight into ocular perfusion...
- Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human bloodTienush Rassaf
Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
Circ Res 91:470-7. 2002..These findings demonstrate that in humans the pharmacological delivery of NO solutions results in the transport and delivery of NO as RSNOs along the vascular tree...
- Carboxy-PTIO, a scavenger of nitric oxide, selectively inhibits the increase in medullary perfusion and improves renal function in endotoxemiaColin G M Millar
Department of Experimental Medicine and Nephrology, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, United Kingdom
Shock 18:64-8. 2002....
- Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitisR P Mookerjee
Liver Failure Group, Institute of Hepatology, London, UK
Gut 52:1182-7. 2003..The role of proinflammatory cytokines in the pathogenesis of portal hypertension is unclear...
- Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumptionPhilip E James
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, United Kingdom
Nitric Oxide 6:18-28. 2002..These site-specific measurements of pO2 provide in vivo evidence that the principal cause of liver hypoxia during hypodynamic sepsis is reduced oxygen supply to the sinusoid and can be alleviated by maintaining sinusoidal perfusion...
- Why protect the right ventricle in patients with acute respiratory distress syndrome?Antoine Vieillard-Baron
Medical Intensive Care Unit, University Hospital Ambroise Pare, 9 avenue Charles de Gaulle, 92104 Boulogne Cedex, France
Curr Opin Crit Care 9:15-21. 2003..Past lessons, however, have taught us that this potential may be limited and lead us to recommend right ventricular protection during mechanical ventilation...
- Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspectiveTudor M Griffith
Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
Biorheology 39:307-18. 2002..There is growing evidence that NO/prostanoid independent relaxations involve direct heterocellular signalling between endothelial and smooth muscle cells via gap junctions...
- Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheepChristopher J Charles
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, New Zealand
Endocrinology 147:1871-7. 2006..Thus, AM-2 may be another important regulator of volume and pressure homeostasis and may play a role in the pathophysiology of heart disease...
- The effect of peripheral resistance on impedance cardiography measurements in the anesthetized dogLester A H Critchley
Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Anesth Analg 100:1708-12. 2005..The bias changed by 0.62 +/- 1.8 L/min, or by 34%, every time TPR halved or doubled. This finding explains the poor agreement between COIC and other methods of CO measurement found in validation studies involving critically ill patients...
- The effects of experimental venous carbon dioxide embolization on hemodynamic and respiratory variablesU Jersenius
Section of Surgery, Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
Acta Anaesthesiol Scand 50:156-62. 2006..The aim of this study was to evaluate the cardiopulmonary effects in a pig model during a time period of 4 h after an experimental CO2 embolization...
- Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarmingCorinna Mirjam Gebauer
Department of Neonatology, Children s Hospital, University of Leipzig, Leipzig, Germany
Pediatrics 117:843-50. 2006..To assess changes in cardiac performance, with Doppler echocardiography, among newborns with hypoxic-ischemic encephalopathy during mild therapeutic hypothermia and during rewarming...
- Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheepChristopher J Charles
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
J Endocrinol 189:701-10. 2006..Apelin also increases circulating levels of a number of vasoactive hormones. Taken together, these results suggest a potential role for apelin in pressure/volume homeostasis...
- Cardiovascular responses to static exercise in boys: insights from tissue Doppler imagingThomas Rowland
Department of Pediatrics, Baystate Medical Center, Springfield, MA 01106, USA
Eur J Appl Physiol 97:637-42. 2006..These findings suggest that (1) cardiovascular responses to static leg extension in boys are similar to those in adult men, and (2) isometric leg extension triggers modest increases in both systolic and diastolic function...
- Haemodynamic effects of remifentanil in children with and without intravenous atropine. An echocardiographic studyC Chanavaz
Department of Anesthesiology and Surgical Intensive Care, Pediatric and Physiology Hôpital Pontchaillou, Universite de Rennes 1, Rennes, France
Br J Anaesth 94:74-9. 2005..Remifentanil is known to cause bradycardia and hypotension. We aimed to characterize the haemodynamic profile of remifentanil during sevoflurane anaesthesia in children with or without atropine...
- Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failureHans Peter Hermann
Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Str 40, Göttingen D 37075, Germany
Eur J Heart Fail 6:213-8. 2004..Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure...
- Effect of 6-week endurance training on hemodynamic and neurohormonal responses to lower body negative pressure (LBNP) in healthy young menK Nazar
Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
J Physiol Pharmacol 57:177-88. 2006..It is concluded that some subjects with low orthostatic tolerance may benefit from moderate training due to improvement of cardiac function regulation...
- Effect of gastric distension on cardiovascular parameters: gastrovascular reflex is attenuated in the elderlyN P van Orshoven
Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
J Physiol 555:573-83. 2004..The fundic compliance did not differ between groups. We conclude that stepwise gastric distension caused an increase in muscle sympathetic nerve activity in both groups, but the increase in the elderly was attenuated...
- Effect of differences in post-exercise lactate accumulation in athletes' haemodynamicsAntonio Crisafulli
Department of Science Applied to Biological Systems, Section of Human Physiology, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
Appl Physiol Nutr Metab 31:423-31. 2006..Nevertheless, mechanisms controlling the cardiovascular apparatus successfully prevented a drop in blood pressure in spite of the cardiovascular stress...
- Contribution of baroreflex sensitivity and vascular reactivity to variable haemodynamic responses to cocaine in conscious ratsMichael Traub
Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63104, USA
Clin Exp Pharmacol Physiol 32:911-8. 2005..More importantly, the differences in vascular responsivity and BRS do not appear to be primary determinants of haemodynamic response variability...
- The contribution of the coronary concentrations of propofol to its cardiovascular effects in anesthetized sheepDa Zheng
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital University of Adelaide, North Terrace, Adelaide, Australia
Anesth Analg 96:1589-97, table of contents. 2003..6 mm Hg for each milligram per liter. There was a larger reduction (2.5 mm Hg x mg(-1) x L(-1)) for the IV route. Therefore, this effect was predominantly mediated by propofol concentrations elsewhere in the body...
- Vasoconstrictor reserve and sympathetic neural control of orthostasisQi Fu
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, Tex 75231, USA
Circulation 110:2931-7. 2004..We tested the hypothesis that individual variability in orthostatic tolerance is dependent on the degree of neural and vasomotor reserve available for vasoconstriction...
- Coronary sinus venoarterial CO2 difference in different hemodynamic statesG Vretzakis
University Hos of Alexandroupolis, Greece
Acta Anaesthesiol Belg 55:221-7. 2004..Under these circumstances, deltaP(cs-a)CO2 appears stable and is not suitable for clinical decisions concerning heart's coronary flow...
- Prolonged recirculation is required to detect secondary metabolic and hemodynamic deterioration after superior mesenteric artery occlusionMichael Lauterbach
Institute for Neurosurgical Pathophysiology, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Clin Hemorheol Microcirc 32:1-12. 2005..Prolonged observation periods are required to detect these significant changes which are overlooked when only studying 120 minutes of reperfusion as usually done...
- Maintained cardiac pumping in anoxic crucian carpJonathan A W Stecyk
Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby V5A 1S6, Canada
Science 306:77. 2004..These responses point to an unusual tolerance of a vertebrate heart and autonomic nervous system to prolonged anoxia...
- Normobaric hyperoxia reduces cardiac index in patients after coronary artery bypass surgeryJohann M Harten
Department of Anaesthesia, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom
J Cardiothorac Vasc Anesth 19:173-5. 2005..The purpose of this study was to assess the hemodynamic changes in response to normobaric hyperoxia in patients immediately after coronary artery bypass surgery...
- Central beta-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stressRuth A Rauls
Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
Brain Res 1048:98-107. 2005..The results suggest that startle elicits hemodynamic responses that are primarily dependent on beta1-adrenoceptors but responses to sustained stress are dependent on beta2-adrenoceptors in the CNS...
- The hemodynamic effect of calcium ion concentration in the infusate during predilution hemofiltration in chronic renal failureNikolaos Karamperis
Department of Renal Medicine C, Skejby, Aarhus University Hospital, Aarhus, Denmark
Am J Kidney Dis 46:470-80. 2005..The aim of this study is to investigate the influence of calcium ion concentration in the substitution fluid on hemodynamic stability during predilution hemofiltration (HF)...
- Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized studyJacques Albanese
Department of Intensive Care Medicine and Trauma Center, Hospital Nord, Marseille Cedex 20, France
Crit Care Med 33:1897-902. 2005..To compare, in patients with hyperdynamic septic shock, the effects of norepinephrine or terlipressin on hemodynamic variables and renal function...
- Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failureNicholas L M Cruden
Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom EH16 4SB
Arterioscler Thromb Vasc Biol 24:1043-8. 2004..Using B9340, a bradykinin receptor antagonist, we determined the contribution of bradykinin to the systemic hemodynamic effects of long-term ACE inhibition in patients with chronic heart failure...
- [The effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption of dogs]Zao hua Zhang
Institute of Traditional Chinese Medicine information, China Academy of Traditional Chinese Medicine, Beijing 100700, China
Zhongguo Zhong Yao Za Zhi 30:1001-5. 2005..To study the effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption for analyzing its underlying mechanism in the treatment of coronary heart disease...
- Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levelsKazuki Nakajima
First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu 514 0823, Japan
Int J Cardiol 104:332-7. 2005..Thus, ANP infusion may improve LV diastolic function even in patients with moderate heart failure and high plasma BNP levels...
- Exaggerated platelet and hemodynamic reactivity to mental stress in men with coronary artery diseasePhilip C Strike
Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
Psychosom Med 66:492-500. 2004..This study compared the effects of acute mental stress on cardiovascular and subjective responses and platelet activation in male patients with established coronary artery disease (CAD) and age-matched controls...
- Improving hemodynamics by atrial pacing during off-pump bypass surgeryVassilios Gulielmos
Department of Thoracic and Cardiovascular Surgery, Heart Center Dresden, University Hospital, Dresden, Germany
Heart Surg Forum 6:E179-82. 2003..To avoid hemodynamic deterioration during tilting of the heart in off-pump surgery, we perform atrial pacing. We describe hemodynamic evaluation of this simple maneuver...
- Central and peripheral hemodynamic effects of losartan and in combination with hydrochlorothiazide in mild to moderate essential hypertensionValery I Podzolkov
Clinic of Internal Diseases, Sechenov Moscow Medical Academy, Moscow, Russia
Blood Press 12:239-45. 2003..We aimed to clarify the effects of losartan and its combination with hydrochlorothiazide on 24-h blood pressures (BPs), central hemodynamics and microcirculation in essential hypertension (EH)...
- Renal anemia and its hemodynamic response--findings invasively determined over a period of 20 yearsG E Schäfer
Medical Hospital III, Clinic Offenbach am Main, Germany
Clin Nephrol 58:S52-7. 2002..Early correction of anemia seems to reduce the risk of fatal cardial complications and to improve the quality of life and the prognosis of pre-uremic patients...
- Regional hemodynamic effects of nociceptin/orphanin FQ in the anesthetized ratAly M Abdelrahman
Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Eur J Pharmacol 450:263-6. 2002..Thus, nociceptin causes generalized vasodilatation; its greatest influence is on the skeletal muscle bed...
- The effect of profiled hemodialysis on intradialytic hemodynamics when a proper sodium balance is appliedB Straver
Department of Nephrology, Institute for Cardiovascular Research VU ICaR VU, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Blood Purif 20:364-9. 2002..The present study investigated the effect of profiled HD, without an accompanying sodium loading, on intradialytic hemodynamics in stable HD patients...
- Hemodynamic responses to stress among black women: fitness and parental hypertensionErica M Jackson
Department of Health and Human Performance, Auburn University, Auburn, AL 36849 5323
Med Sci Sports Exerc 34:1097-104; discussion 1105. 2002..We compared hemodynamic aspects of the relationship between cardiorespiratory fitness and blood pressure changes during and after laboratory stress in young black women with or without parental history of hypertension...
- Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dogKentaro Setoyama
Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan
J Vet Med Sci 64:499-503. 2002..In addition, milrinone is very potent in improving severe congested hemodynamics which complicates hypoxic pulmonary vasoconstriction...
- The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in the perinatal lambYashu Coe
Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada
J Pharmacol Exp Ther 302:672-80. 2002..We conclude that PD 156707 and PD 180988 are selective inhibitors of pulmonary vasoconstriction resulting from hypoxia. Our findings support the use of these or allied compounds in the management of pulmonary hypertension in the neonate...
- Thoracic sympathectomy: effects on hemodynamics and baroreflex controlRené Kingma
Department of Anaesthesiology, VU University Medical Center, Amsterdam, The Netherlands
Clin Auton Res 12:35-42. 2002..High frequency power of HR as well as baroreflex sensitivity, both parasympathetic markers, did not change in a statistically significant manner...
- Skin cooling maintains cerebral blood flow velocity and orthostatic tolerance during tilting in heated humansThad E Wilson
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75321, USA
J Appl Physiol 93:85-91. 2002..Hence, skin-surface cooling may be a potent countermeasure to protect against orthostatic intolerance observed in heat-stressed humans...
- Detecting Endothelial Dysfunction in Renal FailureJulian Stewart; Fiscal Year: 2007..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
- ADVANCED OPTICAL IMAGE PROBE FOR NEUROPHYSIOLOGYDavid Rector; Fiscal Year: 2009..Changes in light absorbance associated with metabolic and hemodynamic processes are robust and relatively easy to obtain non-invasively, but spatial and temporal resolution is limited by ..
- NOVEL METHODS FOR FUNCTIONAL BRAIN IMAGINGCHRISTOPHER DECHARMS; Fiscal Year: 2005..of activation that rely upon blood flow are inherently limited by the temporal and spatial scales of hemodynamic processes. Methods using electrical measurements (EEG) or magnetic measurements (MEG) are capable of high temporal ..
- CLINICAL APPLICATION OF END SYSTOLIC P-V RELATIONSMark Starling; Fiscal Year: 2000..of spherical geometry, and that surgery for LV volume overload at this time will reverse these detrimental hemodynamic processes and, thereby, preserve or restore normal LV size and performance...
- Nitric Oxide in Tumor Physiology: A Bioengineering ModelJAMES BAISH; Fiscal Year: 2002..Nitric oxide is involved in numerous vascular and hemodynamic processes in solid tumors that depend upon its local concentration...
- Neural and metabolic activity in vision and attentionJACK GALLANT; Fiscal Year: 2005..We propose to investigate the relationship between neural, metabolic and hemodynamic processes by use of a novel multispectral probe that allows simultaneous measurement of neural, metabolic and ..
- NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIAShailendra Joshi; Fiscal Year: 2005..abstract_text> ..
- Circulatory Dysfunction in Chronic Fatigue SyndromeJulian Stewart; Fiscal Year: 2004....
- Genetic Risk Factors for Portopulmonary HypertensionSteven Kawut; Fiscal Year: 2005..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
- Neurohormonal Activation in Pulmonary HypertensionSteven Kawut; Fiscal Year: 2005..We will formulate prediction rules using neurohormone levels and clinical variables to improve prognostication and management in this disease. ..
- Nutritional/Inflammatory Evaluation of Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2005....
- ACTION-A CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISEWilliam Abraham; Fiscal Year: 2005..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
- Ischemic Arrest, Cytokines, and Organ DysfunctionJames Niemann; Fiscal Year: 2008..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..
- Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Effect of Drugs on Myocardial HypoxiaGarrett Gross; Fiscal Year: 2009..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
- Bridge to neonatal Fontan repair of single ventricleMark Rodefeld; Fiscal Year: 2006..abstract_text> ..
- Angiogenesis and Cardiac Growth as Heart Failure TherapyY Woo; Fiscal Year: 2008..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
- Sympathetic Regulation of Endotoxemia in Drug AbuseMARK KNUEPFER; Fiscal Year: 2005..This information will contribute to our understanding of predisposing factors to the incidence and severity of septic shock in humans and the mechanisms by which cocaine use affects this process. ..
- OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTIONDANIEL KAPUSTA; Fiscal Year: 2003..In summary, an RCDA will greatly enhance my research productivity and scientific career. ..
- CARDIOVASCULAR EFFECTS OF COCAINEMARK KNUEPFER; Fiscal Year: 2001..Furthermore, our studies offer a novel model by which individuals at greater risk for cocaine- or stress-related heart disease may be identified. ..
- MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFERDavid Poole; Fiscal Year: 2001....
- Neurovascular Factors in Functional MRIThomas T Liu; Fiscal Year: 2010..The specific aims of this project are to identify the measures that most effectively explain changes in resting-state connectivity due to (a) caffeine usage and (b) inter-subject differences in physiology. ..
- OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTIONDANIEL KAPUSTA; Fiscal Year: 2007..abstract_text> ..
- Bradykinin Receptor Antagonism During Cardiopulmonary BypassMias Pretorius; Fiscal Year: 2010..These studies promise to provide important information regarding the effects of drugs that interrupt the RAS and generate new strategies to reduce morbidity in patients undergoing CPB. ..
- Nanoscale approaches to allelic silencing in myocardial disease statesEuan Ashley; Fiscal Year: 2009..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..
- Chronic Stress or Psychostimulants on Central and Autonomic Nervous SystemsMark M Knuepfer; Fiscal Year: 2010..The results will illuminate the similarities and differences in central autonomic and neuroendocrine responsiveness to stress and psychostimulants. ..
- Cardio-renal actions of novel nociceptin analoguesDANIEL KAPUSTA; Fiscal Year: 2008..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
- PHARMACOLOGY OF COMBINED EPHEDRINE/CAFFEINE SUPPLEMENTSChristine Haller; Fiscal Year: 2004..The long-term objective for the proposed studies is to develop Dr. Haller into an independent career clinical researcher in this field of study. ..
- Assessment of Muscle Vascular Disease with Diffuse LightGuoqiang Yu; Fiscal Year: 2007..The proposed, noninvasive, portable, and inexpensive optical technology may fill in this gap by providing multiple hemodynamic information and by enabling continuous measurements at the bed-side and in ambulatory care. ..
- PEDIATRIC CARDIOMYOPATHY REGISTRYSteven Lipshultz; Fiscal Year: 2009..These studies will dramatically increase our understanding of pediatric cardiomyopathy, suggest new areas of research and improved patient management. ..
- Functional Relevance of Spontaneous BOLD FluctuationsMichael Fox; Fiscal Year: 2008..Further, the functional relevance of spontaneous BOLD fluctuations is important for understanding reported disturbances in these fluctuations in different pathological conditions. ..
- Full Head, High Density Functional Diffuse Optical TomographyJoseph Culver; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ANP Modulates Cardiac Remodeling via Cardiac FibroblastsYiu Fai Chen; Fiscal Year: 2009..These mechanistic studies will provide a more rational basis for therapeutic intervention in patients with cardiac dysfunction/failure, many of whom have decreased levels of ANP. ..
- SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTSCharles Wood; Fiscal Year: 2008..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
- Adrenergic Antagonism During Murine CandidiasisBrad Spellberg; Fiscal Year: 2008..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
- Effect of Adenosine A2 receptor activation on the mitochondrial death pathwayZhelong Xu; Fiscal Year: 2010....
- Vascular Mechanisms of Cerebral Ischemic ToleranceJEFFREY GIDDAY; Fiscal Year: 2008..abstract_text> ..
- Regulation of H/K-ATPase in Kidney and ColonBRUCE KONE; Fiscal Year: 2009..abstract_text> ..
- Characterization of Toxicity with Spinal OpiatesTony L Yaksh; Fiscal Year: 2010..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
- Innate Effectors of rAls3p-N Anti-Candida VaccineBrad J Spellberg; Fiscal Year: 2010..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
- ADENOSINE AND TRAUMATIC BRAIN INJURYPatrick Kochanek; Fiscal Year: 2007..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
- INTEGRATIVE ASPECTS OF CARDIOVASCULAR FUNCTIONDon Sheriff; Fiscal Year: 2005....
- NEUROBIOLOGY OF PAINTony Yaksh; Fiscal Year: 2005..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
- Modulatory Effect of Acupuncture on Human Brain ActivityKathleen Hui; Fiscal Year: 2003..abstract_text> ..
- CRANIOFACIAL MORPHOGENESIS IN PRENATAL ALCOHOL EXPOSURESusan Smith; Fiscal Year: 2005..Results also may provide possible explanations for genetic-based variations in fetal responses to prenatal ethanol exposure. ..
- VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTIONSteven Schulman; Fiscal Year: 2004..We anticipate that the study findings will suggest the use of new evaluation and therapeutic strategies, which will significantly decrease the age associated mortality and morbidity in post-infarction patients. ..
- Mixed-Effects ZIP Models--Mental Health Service ResearchRobert Gibbons; Fiscal Year: 2004..abstract_text> ..
- Renal Microcirculatory and Tubular DynamicsJoey Granger; Fiscal Year: 2004....
- SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESSMICHAEL KENNEY; Fiscal Year: 2004..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
- INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASEJohn Kinsella; Fiscal Year: 2004..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
- Estrogen and the Aging Blood Brain BarrierOAK CHI; Fiscal Year: 2002..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
- Diastolic Dysfunction & Atrial Fibrillation in ElderlyTERESA TSANG; Fiscal Year: 2007..Identification of the cascade of factors contributing to AF development will have important implications in primary prevention of this major public health problem. ..
- Psychopharmacology of Autism and related DisordersDavid Posey; Fiscal Year: 2007..Towards the later years of the award, the candidate will have performed additional studies and applied for independent research funding. ..
- REGIONAL BETA ADRENERGIC DURING LV REMODELINGChristopher Kramer; Fiscal Year: 2002..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
- GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTSDEEPAK D SOUZA; Fiscal Year: 2002..Pilot data (n=12) towards this proposal suggests that glycine reduces ketamine-induced perceptual alterations, negative symptoms and impairments on recall without worsening positive symptoms. ..
- SERCA2a Abnormalities and Chaperones in Heart FailureFederica Del Monte; Fiscal Year: 2006..abstract_text> ..
- Cardiovascular Status of HAART-Exposed Infants/ChildrenSteven Lipshultz; Fiscal Year: 2006..This study will determine the cardiovascular effects of HAART in seroreverters and the need for future cardiovascular follow-up and cardiovascular preventive and therapeutic trials in this rapidly expanding population. ..
- Nitric oxide and superoxide effects on the failing heartYingjie Chen; Fiscal Year: 2006..Additional studies will determine whether mRNA and protein expression and activity for eNOS, nNOS, iNOS, CuZn-SOD, Mn-SOD and Ec-SOD are altered in coronary vessels and myocardium by the presence of CHF. ..
- Multi-photon and fluorescence-lifetime microscope for in-vivo functional imagingDavid Boas; Fiscal Year: 2006..This system will be an invaluable resource for the many interdisciplinary research projects within the Martinos center, in the surrounding MGH community, and for many others in the greater Boston area. [unreadable] [unreadable]..
- ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVESMichael Sacks; Fiscal Year: 2004..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
- Controlled-Release HIF-1 Delivery for ArteriogenesisLawrence Hofmann; Fiscal Year: 2005..These projects and career development plans will provide the resources, collaborative relationships, and academic foundation of which the candidate will build a successful career as an independent clinical scientist. ..
- fMRI and TMS of Motor Recovery after Hemiparetic StrokeJudith Schaechter; Fiscal Year: 2007..abstract_text> ..
- ATRIAL NATRIURETIC PEPTIDE AND RECEPTOR GENES IN HYPOXIAYiu Fai Chen; Fiscal Year: 2010..Our proposed mechanistic studies will lead to innovative and effective therapeutic approaches to this important cause of morbidity and mortality in the American population. ..
- Novel epoxide hydrolase inhibitor for stroke preventionJOHN IMIG; Fiscal Year: 2005..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
- PRICE: Pivotal Research in Cardiology in the ElderlyMichael Rich; Fiscal Year: 2008....
- HEMORHEOLOGY STUDIES RELATED TO IN VIVO BLOOD FLOWHERBERT MEISELMAN; Fiscal Year: 2008....