hemodynamic processes

Summary

Summary: Biological actions and events that support the functions involved in systemic or regional BLOOD CIRCULATION.

Top Publications

  1. ncbi Norepinephrine and vital organ blood flow
    David Di Giantomasso
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
    Intensive Care Med 28:1804-9. 2002
  2. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
  3. pmc Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care 7:359-73. 2003
  4. ncbi Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 32:1825-31. 2004
  5. ncbi Intradialytic hypotension: an overview of recent, unresolved and overlooked issues
    Richard A Sherman
    Semin Dial 15:141-3. 2002
  6. ncbi A numerical study of blood flow in coronary artery bypass graft side-to-side anastomoses
    Michael Bonert
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Ann Biomed Eng 30:599-611. 2002
  7. ncbi Effect of desflurane-induced preconditioning following ischemia-reperfusion on nitric oxide release in rabbits
    Shen Kou Tsai
    Department of Anesthesiology, College of Medicine, National Yang Ming University and National Taiwan University, Taipei Veterans General Hospital, 201, Shih Pai Road, Second, Taipei, Taiwan
    Life Sci 76:651-60. 2004
  8. ncbi An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury
    Michael Quintel
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum, Mannheim, Mannheim, Germany
    Am J Respir Crit Care Med 169:534-41. 2004
  9. pmc Renal blood flow in sepsis
    Christoph Langenberg
    Department of Intensive Care, Austin Hospital, and University of Melbourne, Heidelberg, Melbourne, Australia
    Crit Care 9:R363-74. 2005
  10. ncbi Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury
    Antoine Roch
    Service de Reanimation Polyvalente, hopitaux Sud, Marseille, France
    Crit Care Med 32:811-7. 2004

Research Grants

Detail Information

Publications192 found, 100 shown here

  1. ncbi Norepinephrine and vital organ blood flow
    David Di Giantomasso
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
    Intensive Care Med 28:1804-9. 2002
    ..To test whether norepinephrine (NE) infusion at 0.4 microg kg(-1) min(-1) adversely affects regional blood flow in the normal mammalian circulation...
  2. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
    ....
  3. pmc Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care 7:359-73. 2003
    ..NO also regulates mitochondrial respiration. During sepsis, NO over-production mediates systemic hypotension and microvascular reactivity, and is seemingly protective of microvascular blood flow...
  4. ncbi Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 32:1825-31. 2004
    ..To characterize the time course of microcirculatory alterations and their relation to outcome in patients with septic shock...
  5. ncbi Intradialytic hypotension: an overview of recent, unresolved and overlooked issues
    Richard A Sherman
    Semin Dial 15:141-3. 2002
    ..While many risk factors have been identified, the issues of sodium and thermal balance and variability in left ventricular filling have not been adequately emphasized or investigated...
  6. ncbi A numerical study of blood flow in coronary artery bypass graft side-to-side anastomoses
    Michael Bonert
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Ann Biomed Eng 30:599-611. 2002
    ..We studied hemodynamics in idealized models of "parallel" and "diamond" side-to-side anastomoses, identifying features that might promote restenosis...
  7. ncbi Effect of desflurane-induced preconditioning following ischemia-reperfusion on nitric oxide release in rabbits
    Shen Kou Tsai
    Department of Anesthesiology, College of Medicine, National Yang Ming University and National Taiwan University, Taipei Veterans General Hospital, 201, Shih Pai Road, Second, Taipei, Taiwan
    Life Sci 76:651-60. 2004
    ..This beneficial effect of desflurane on the ischemic preconditioning is probably through NO release since L-NAME abrogates the desflurane preconditioning effect...
  8. ncbi An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury
    Michael Quintel
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum, Mannheim, Mannheim, Germany
    Am J Respir Crit Care Med 169:534-41. 2004
    ..We conclude that in OA-injured lung, the increase of IAP increases the amount of edema...
  9. pmc Renal blood flow in sepsis
    Christoph Langenberg
    Department of Intensive Care, Austin Hospital, and University of Melbourne, Heidelberg, Melbourne, Australia
    Crit Care 9:R363-74. 2005
    ..To assess changes in renal blood flow (RBF) in human and experimental sepsis, and to identify determinants of RBF...
  10. ncbi Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury
    Antoine Roch
    Service de Reanimation Polyvalente, hopitaux Sud, Marseille, France
    Crit Care Med 32:811-7. 2004
    ....
  11. ncbi Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update
    Steven M Hollenberg
    Crit Care Med 32:1928-48. 2004
    ..To provide the American College of Critical Care Medicine with updated guidelines for hemodynamic support of adult patients with sepsis...
  12. ncbi Comparative effects of vasopressin, norepinephrine, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in endotoxic shock
    Bruno Levy
    Groupe de Recherche en Physiopathologie Respiratoire, Institut de Pharmacologie, Universite de Sherbrooke, Quebec, Canada J1H 5N4
    Am J Physiol Heart Circ Physiol 287:H209-15. 2004
    ..These results suggest that, in a short-term endotoxic shock model, AVP improves systemic hemodynamics without side effects and has particular beneficial effects on renal function...
  13. ncbi Endocrinologic response to vasopressin infusion in advanced vasodilatory shock
    Martin W Dunser
    Division of General and Surgical Intensive Care Medicine, Department of Anesthesiology and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Innsbruck, Austria
    Crit Care Med 32:1266-71. 2004
    ....
  14. ncbi Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channels
    Eric Dubuis
    LABPART, Faculte de Medecine, 2 bis Boulevard Tonnelle, 37032 Tours, France
    Cardiovasc Res 65:751-61. 2005
    ....
  15. ncbi Impact of high volume hemofiltration on hemodynamic disturbance and outcome during septic shock
    Olivier Joannes-Boyau
    Department of Anesthesiology and Critical Care II, University of Bordeaux, Pessac, France
    ASAIO J 50:102-9. 2004
    ..This study suggests a beneficial effect of HVCVVH on 28 day mortality (46% vs. 70%), and further studies with larger cohorts are required...
  16. ncbi Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis
    Christopher G Ellis
    Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8, Canada
    Am J Physiol Heart Circ Physiol 282:H156-64. 2002
    ..Capillary O(2) extraction increased threefold (P < 0.05) and was directly related to the degree of stopped flow in the EDL. Thus impaired O(2) transport in early stage sepsis is likely the result of a microcirculatory dysfunction...
  17. ncbi Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia
    Antje Pittner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Intensive Care Med 29:312-6. 2003
    ..To determine the mechanisms of improved gut mucosal acidosis associated with selective inducible nitric oxide synthase (iNOS) inhibition...
  18. ncbi Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis
    Sambit Sen
    Liver Failure Group, Institute of Hepatology, University College London Medical School, 69 75 Chenies Mews, London WC1E 6HX, UK
    J Hepatol 43:142-8. 2005
    ..This study evaluates the acute effects of albumin dialysis, using the Molecular Adsorbents Recirculating System (MARS), on portal pressure in AH...
  19. ncbi Prone positioning, systemic hemodynamics, hepatic indocyanine green kinetics, and gastric intramucosal energy balance in patients with acute lung injury
    Rudolf Hering
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Intensive Care Med 28:53-8. 2002
    ..To investigate the effects of prone positioning on systemic hemodynamics, intra-abdominal pressure (IAP), plasma disappearance rate of indocyanine green (PDR(ICG)), and gastric intramucosal to arterial PCO2 difference (Pi-aCO2)...
  20. ncbi High-dose vasopressin is not superior to norepinephrine in septic shock
    Stefan Klinzing
    Department of Anesthesiology and Intensive Care Medicine, Freidrich Schiller University, Jena, Germany
    Crit Care Med 31:2646-50. 2003
    ..We examined the effects of arginine vasopressin, when substituted for norepinephrine as a vasopressor in septic shock, on global and hepatosplanchnic hemodynamic and oxygen transport variables...
  21. ncbi Myocardial dysfunction in the patient with sepsis
    Sreenandh Krishnagopalan
    Section of Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Curr Opin Crit Care 8:376-88. 2002
    ..In addition, septic myocardial depression appears to be mediated in part through combinations of nitric oxide-dependent and -independent alterations of basal and catecholamine-stimulated cardiac myocyte contractility...
  22. ncbi Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses
    Stina Marntell
    Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Anaesth Analg 32:83-93. 2005
    ..To study pulmonary gas exchange and cardiovascular responses to sedation achieved with romifidine and butorphanol (RB) alone, or combined with acepromazine, and during subsequent tiletamine-zolazepam anaesthesia in horses...
  23. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  24. ncbi Effect of prone position on hepato-splanchnic hemodynamics in acute lung injury
    Martin Matejovic
    Intensive Care Unit, 1st Medical Department, Charles University Hospital Plzen, Alej Svobody 80, 304 60 Plzen, Czech Republic
    Intensive Care Med 28:1750-5. 2002
    ..To evaluate the effects of prone position on hepato-splanchnic hemodynamics, metabolism and gut mucosal energy balance...
  25. ncbi Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients
    Thierry Boulain
    Service de Reanimation Medicale, Hopital de Bicetre, Faculte de Medecine Paris Sud, Paris, France
    Chest 121:1245-52. 2002
    ....
  26. ncbi Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shock
    Anthony Chin
    Divisions of Pediatric Surgery, Department of Surgery and Pediatrics, The University of Illinois College of Medicine at Chicago, Chicago, IL, USA
    J Pediatr Surg 37:482-7. 2002
    ..In this study the authors have examined the effects of tezosentan, a dual endothelin-receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxemia...
  27. ncbi Opening the microcirculation: can vasodilators be useful in sepsis?
    Mattijn Buwalda
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Intensive Care Med 28:1208-17. 2002
    ....
  28. ncbi Intrarenal blood flow distribution in hyperdynamic septic shock: Effect of norepinephrine
    David Di Giantomasso
    Department of Medicine, Melbourne University Austin and Repatriation Medical Centre, Heidelberg, Australia
    Crit Care Med 31:2509-13. 2003
    ..To measure changes in medullary and cortical renal blood flow during experimental hyperdynamic sepsis and the effect of subsequent norepinephrine infusion on such flows. DESIGN Experimental animal study...
  29. ncbi Hepatic and systemic haemodynamic changes after MARS in patients with acute on chronic liver failure
    Maria Vega Catalina
    Hepatic Hemodynamic Unit, Department of Hepatology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Liver Int 23:39-43. 2003
    ..01). MARS decreases portal hypertension and ameliorates hyperdynamic circulation in patients with AoCLF, probably mediated by clearance of vasoactive substances. Further studies are necessary to confirm these results...
  30. ncbi Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategy
    Salvatore Grasso
    Servizio di Anestesiologia e Rianimazione, Ospedale Di Venere, Bari, Italy
    Anesthesiology 96:795-802. 2002
    ..This study examined the hypothesis that the effectiveness of a recruiting maneuver to improve oxygenation in patients with ARDS would be influenced by the elastic properties of the lung and chest wall...
  31. ncbi Effects of end-inspiratory and end-expiratory pressures on alveolar recruitment and derecruitment in saline-washout-induced lung injury -- a computed tomography study
    T Luecke
    Department of Anesthesiology and Intensive Care, University Hospital of Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Germany
    Acta Anaesthesiol Scand 48:82-92. 2004
    ....
  32. ncbi Meta-analysis of hemodynamic optimization in high-risk patients
    Jack W Kern
    USC School of Pharmacy, Los Angeles, CA, USA
    Crit Care Med 30:1686-92. 2002
    ....
  33. pmc Clinical review: Hypertonic saline resuscitation in sepsis
    Roselaine P Oliveira
    Department of Critical Care Medicine, Santa Casa Hospital, Federal University of Rio Grande do Sul, Porto Alegra, Brazil
    Crit Care 6:418-23. 2002
    ..The goal of research in this field is to identify reliable therapies to prevent ischemia and inflammation, and to reduce mortality...
  34. ncbi [Arginine vasopressin in vasodilatory shock: a new therapy approach?]
    M Dunser
    Klinische Abteilung für Allgemeine und Chirurgische Intensivmedizin, Univ Klinik für Anästhesie und Allgemeine Intensivmedizin Leopold Franzens Universität Innsbruck, Germany
    Anaesthesist 51:650-9; discussion 659-60. 2002
    ..Therefore, arginine vasopressin should be restricted to patients where adequate stabilization of hemodynamic function cannot be achieved by conventional vasopressor therapy alone...
  35. ncbi Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study
    Martin W Dunser
    Division of General and Surgical Intensive Care Medicine, Department of Anesthesia and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Circulation 107:2313-9. 2003
    ..Arginine vasopressin (AVP) has recently been shown to be a potent vasopressor agent to stabilize cardiocirculatory function even in patients with catecholamine-resistant vasodilatory shock...
  36. ncbi Norepinephrine and vital organ blood flow during experimental hyperdynamic sepsis
    David Di Giantomasso
    Howard Florey Institute, Parkville, Melbourne, Australia
    Intensive Care Med 29:1774-81. 2003
    ..To study the effect of norepinephrine (NE) infusion on cerebral, coronary, renal and mesenteric blood flow during sepsis...
  37. ncbi Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock
    Miriam M Treggiari
    Surgical Intensive Care Division, Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital, Geneva, Switzerland
    Crit Care Med 30:1334-9. 2002
    ..To evaluate the effect of a norepinephrine-induced differential increase in mean arterial pressure on splanchnic and renal perfusion in a porcine model of volume-resuscitated endotoxic shock...
  38. ncbi Terlipressin for norepinephrine-resistant septic shock
    Alastair O'Brien
    Lancet 359:1209-10. 2002
    ..Terlipressin seems to be an effective rescue therapy, which is able to restore blood pressure in patients with catecholamine-resistant septic shock, without obvious complication...
  39. ncbi Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft
    Kazuo Shirakawa
    Pharmacology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 62:560-6. 2002
    ..These facts led us to hypothesize that the VM of WIBC-9 involves hemodynamics that serve to feed WIBC-9 cells, and this in turn suggests a connection between VM and angiogenesis...
  40. ncbi Effects of dopamine on systemic and regional blood flow and metabolism in septic and cardiac surgery patients
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital, Bern, Switzerland
    Shock 18:8-13. 2002
    ..The safety and indications of dopamine use in sepsis should be re-evaluated...
  41. ncbi Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care Med 31:1659-67. 2003
    ..To assess the effects of different doses of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in patients with septic shock...
  42. ncbi Beneficial effects of short-term vasopressin infusion during severe septic shock
    Bhavesh M Patel
    Department of Critical Care, Mayo Clinic Arizona, Scottsdale, Arizona, USA
    Anesthesiology 96:576-82. 2002
    ....
  43. ncbi A randomised, controlled trial of the pulmonary artery catheter in critically ill patients
    Andrew Rhodes
    Department of Intensive Care, St George s Hospital, London SW17 0QT, UK
    Intensive Care Med 28:256-64. 2002
    ..To compare the survival and clinical outcomes of critically ill patients treated with the use of a pulmonary artery catheter (PAC) to those treated without the use of a PAC...
  44. ncbi Are hypertonic hyperoncotic solutions safe for prehospital small-volume resuscitation? Results of a prospective observational study
    Walter Mauritz
    Department of Anaesthesia and Critical Care, Lorenz Böhler Trauma Center, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Eur J Emerg Med 9:315-9. 2002
    ..Effects on homeostasis and haemodynamics as well as safety were evaluated...
  45. ncbi Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats
    Bruno Levy
    Réanimation Médicale, Hopital Central, 54035, Nancy Cedex, France
    Intensive Care Med 29:292-300. 2003
    ..To determine whether epinephrine increases lactate concentration in sepsis through hypoxia or through a particular thermogenic or metabolic pathway...
  46. pmc Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: role of adrenomedullin and adrenomedullin binding protein-1
    Shaolong Yang
    Center for Surgical Research and Department of Surgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Ann Surg 236:625-33. 2002
    ..To determine whether the combined administration of adrenomedullin and adrenomedullin binding protein-1 (AM/AMBP-1) has any modulatory effects on the cardiovascular response during the progression of sepsis...
  47. ncbi Haemodynamic monitoring with pulse-induced contour cardiac output (PiCCO) in critical care
    Ros Cottis
    Critical Care Unit, Southend Hospital, Prittlewell Chase, Southend on Sea, Essex, UK
    Intensive Crit Care Nurs 19:301-7. 2003
    ..These parameters are of interest as they are considered to be the most specific measures of cardiac preload, pulmonary oedema and contractility and a global indicator of cardiac performance...
  48. ncbi Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies
    Martial G Bourassa
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, Canada, H1T 1C8
    J Am Coll Cardiol 41:351-9. 2003
    ..Successful medical, interventional, or surgical therapy leads not only to marked improvement or normalization of these alterations but also relief of angina and ischemia...
  49. ncbi Cardiovascular effects of romifidine in the standing horse
    S L Freeman
    Department of Farm Animal and Equine Medicine and Surgery, Royal Veterinary College, Hawkshead Lane, N Mymms, Hatfield, Herts, AL9 7TA, UK
    Res Vet Sci 72:123-9. 2002
    ..There were minimal differences between the two doses of romifidine, and both should be used with care especially in horses with cardiovascular compromise, or when used in combination with other cardiovascular depressant drugs...
  50. ncbi Randomised controlled trial investigating the influence of intravenous fluid titration using oesophageal Doppler monitoring during bowel surgery
    D H Conway
    Department of Anaesthesia, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Anaesthesia 57:845-9. 2002
    ..003). Five control patients required postoperative critical care admission. Fluid titration using oesophageal Doppler during bowel surgery can improve haemodynamic parameters and may reduce critical care admissions postoperatively...
  51. ncbi Effects of norepinephrine, epinephrine, and norepinephrine-dobutamine on systemic and gastric mucosal oxygenation in septic shock
    Shao Xia Zhou
    Department of Critical Care Medicine, Zhong Da Hospital and School of Clinical Medicine, Southeast University, Nanjing 210009, China
    Acta Pharmacol Sin 23:654-8. 2002
    ..To compare the effects of dopamine, norepinephrine, epinephrine, and the combination of norepinephrine and dobutamine on systemic and gastric mucosal oxygen metabolism in patients with septic shock...
  52. ncbi Review article: volume expansion in patients with cirrhosis
    J H Henriksen
    Department of linical Physiology 239, Hvidovre Hospital, University of Copenhagen, Denmark
    Aliment Pharmacol Ther 16:12-23. 2002
    ..Timely handling is essential, but difficult as it is a balance between the risks of excess extravascular volume loading and further circulatory dysfunction in these patients with a hyperdynamic, but hyporeactive, circulation...
  53. ncbi Positive pressure mechanical ventilation
    Bhargavi Gali
    Department of Anesthesiology and Critical Care, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Emerg Med Clin North Am 21:453-73. 2003
    ..The role of specific modes and parameters of these devices likely will be further refined to maximize outcomes...
  54. ncbi What is the optimal duration of ventilation in the prone position in acute lung injury and acute respiratory distress syndrome?
    D F McAuley
    Intensive Care Unit, Birmingham Heartlands Teaching Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Intensive Care Med 28:414-8. 2002
    ....
  55. ncbi Impact of perioperative haemodynamic monitoring on cardiac morbidity after major vascular surgery in low risk patients. A randomised pilot trial
    M Bonazzi
    Department of Anesthesia and Intensive Care Unit, Bassini Hospital, via M Gorki 50, 20092 Cinisello Balsamo, Milan, Italy
    Eur J Vasc Endovasc Surg 23:445-51. 2002
    ..to evaluate whether perioperative haemodynamic optimisation influences outcome from infrarenal abdominal aortic aneurysm repair...
  56. ncbi Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock
    Vladimir Krejci
    Department of Anesthesiology, Inselspital, University Hospital of Berne, Switzerland
    Crit Care Med 31:203-10. 2003
    ..The aim of this investigation was to study the effects of an endothelin antagonist on microcirculatory blood flow in multiple abdominal organs during septic shock...
  57. ncbi Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shock
    Jean Charles Preiser
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Shock 20:465-8. 2003
    ..In the presence of endotoxin, ODQ administration increased MBF and prevented the restoration of FBF. Hence, selective inhibition of sGC may increase splanchnic blood flow in septic shock...
  58. ncbi Sublingual capnometry versus traditional markers of tissue oxygenation in critically ill patients
    Paul E Marik
    Department of Critical Care Medicine, Mercy Hospital of Pittsburgh, PA, USA
    Crit Care Med 31:818-22. 2003
    ....
  59. ncbi The changes of hepatic sinusoidal microcirculation and effects of nitric oxide synthase inhibitor during sepsis
    Tsann Long Hwang
    Department of Surgery, Chang Gung Memorial Hospital 199, Tung Hwa N Rd, Taipei, Taiwan
    Hepatogastroenterology 50:213-6. 2003
    ..The changes in hepatic microcirculation corresponding to liver functions and the effects of nitric oxide synthase inhibitor on the liver during sepsis were studied...
  60. ncbi Estimation of choroid perfusion by colour Doppler imaging vs. other methods
    Oliver Zeitz
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Augenheilkunde, Hamburg, Germany
    Ultrasound Med Biol 28:1023-7. 2002
    ..50; p = 0.005; n = 30) and long posterior ciliary arteries (r = 0.41; p = 0.024; n = 30). Methods strengthened each other by partial correlation. The study demonstrates that CDI allows a more detailed insight into ocular perfusion...
  61. ncbi Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood
    Tienush Rassaf
    Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
    Circ Res 91:470-7. 2002
    ..These findings demonstrate that in humans the pharmacological delivery of NO solutions results in the transport and delivery of NO as RSNOs along the vascular tree...
  62. ncbi Carboxy-PTIO, a scavenger of nitric oxide, selectively inhibits the increase in medullary perfusion and improves renal function in endotoxemia
    Colin G M Millar
    Department of Experimental Medicine and Nephrology, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, United Kingdom
    Shock 18:64-8. 2002
    ....
  63. pmc Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis
    R P Mookerjee
    Liver Failure Group, Institute of Hepatology, London, UK
    Gut 52:1182-7. 2003
    ..The role of proinflammatory cytokines in the pathogenesis of portal hypertension is unclear...
  64. ncbi Endotoxin-induced liver hypoxia: defective oxygen delivery versus oxygen consumption
    Philip E James
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Wales, United Kingdom
    Nitric Oxide 6:18-28. 2002
    ..These site-specific measurements of pO2 provide in vivo evidence that the principal cause of liver hypoxia during hypodynamic sepsis is reduced oxygen supply to the sinusoid and can be alleviated by maintaining sinusoidal perfusion...
  65. ncbi Why protect the right ventricle in patients with acute respiratory distress syndrome?
    Antoine Vieillard-Baron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, 9 avenue Charles de Gaulle, 92104 Boulogne Cedex, France
    Curr Opin Crit Care 9:15-21. 2003
    ..Past lessons, however, have taught us that this potential may be limited and lead us to recommend right ventricular protection during mechanical ventilation...
  66. ncbi Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspective
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Biorheology 39:307-18. 2002
    ..There is growing evidence that NO/prostanoid independent relaxations involve direct heterocellular signalling between endothelial and smooth muscle cells via gap junctions...
  67. ncbi Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, New Zealand
    Endocrinology 147:1871-7. 2006
    ..Thus, AM-2 may be another important regulator of volume and pressure homeostasis and may play a role in the pathophysiology of heart disease...
  68. ncbi The effect of peripheral resistance on impedance cardiography measurements in the anesthetized dog
    Lester A H Critchley
    Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Anesth Analg 100:1708-12. 2005
    ..The bias changed by 0.62 +/- 1.8 L/min, or by 34%, every time TPR halved or doubled. This finding explains the poor agreement between COIC and other methods of CO measurement found in validation studies involving critically ill patients...
  69. ncbi The effects of experimental venous carbon dioxide embolization on hemodynamic and respiratory variables
    U Jersenius
    Section of Surgery, Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
    Acta Anaesthesiol Scand 50:156-62. 2006
    ..The aim of this study was to evaluate the cardiopulmonary effects in a pig model during a time period of 4 h after an experimental CO2 embolization...
  70. ncbi Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming
    Corinna Mirjam Gebauer
    Department of Neonatology, Children s Hospital, University of Leipzig, Leipzig, Germany
    Pediatrics 117:843-50. 2006
    ..To assess changes in cardiac performance, with Doppler echocardiography, among newborns with hypoxic-ischemic encephalopathy during mild therapeutic hypothermia and during rewarming...
  71. ncbi Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep
    Christopher J Charles
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    J Endocrinol 189:701-10. 2006
    ..Apelin also increases circulating levels of a number of vasoactive hormones. Taken together, these results suggest a potential role for apelin in pressure/volume homeostasis...
  72. ncbi Cardiovascular responses to static exercise in boys: insights from tissue Doppler imaging
    Thomas Rowland
    Department of Pediatrics, Baystate Medical Center, Springfield, MA 01106, USA
    Eur J Appl Physiol 97:637-42. 2006
    ..These findings suggest that (1) cardiovascular responses to static leg extension in boys are similar to those in adult men, and (2) isometric leg extension triggers modest increases in both systolic and diastolic function...
  73. ncbi Haemodynamic effects of remifentanil in children with and without intravenous atropine. An echocardiographic study
    C Chanavaz
    Department of Anesthesiology and Surgical Intensive Care, Pediatric and Physiology Hôpital Pontchaillou, Universite de Rennes 1, Rennes, France
    Br J Anaesth 94:74-9. 2005
    ..Remifentanil is known to cause bradycardia and hypotension. We aimed to characterize the haemodynamic profile of remifentanil during sevoflurane anaesthesia in children with or without atropine...
  74. ncbi Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure
    Hans Peter Hermann
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Str 40, Göttingen D 37075, Germany
    Eur J Heart Fail 6:213-8. 2004
    ..Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure...
  75. ncbi Effect of 6-week endurance training on hemodynamic and neurohormonal responses to lower body negative pressure (LBNP) in healthy young men
    K Nazar
    Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 57:177-88. 2006
    ..It is concluded that some subjects with low orthostatic tolerance may benefit from moderate training due to improvement of cardiac function regulation...
  76. pmc Effect of gastric distension on cardiovascular parameters: gastrovascular reflex is attenuated in the elderly
    N P van Orshoven
    Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Physiol 555:573-83. 2004
    ..The fundic compliance did not differ between groups. We conclude that stepwise gastric distension caused an increase in muscle sympathetic nerve activity in both groups, but the increase in the elderly was attenuated...
  77. ncbi Effect of differences in post-exercise lactate accumulation in athletes' haemodynamics
    Antonio Crisafulli
    Department of Science Applied to Biological Systems, Section of Human Physiology, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    Appl Physiol Nutr Metab 31:423-31. 2006
    ..Nevertheless, mechanisms controlling the cardiovascular apparatus successfully prevented a drop in blood pressure in spite of the cardiovascular stress...
  78. ncbi Contribution of baroreflex sensitivity and vascular reactivity to variable haemodynamic responses to cocaine in conscious rats
    Michael Traub
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Clin Exp Pharmacol Physiol 32:911-8. 2005
    ..More importantly, the differences in vascular responsivity and BRS do not appear to be primary determinants of haemodynamic response variability...
  79. ncbi The contribution of the coronary concentrations of propofol to its cardiovascular effects in anesthetized sheep
    Da Zheng
    Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital University of Adelaide, North Terrace, Adelaide, Australia
    Anesth Analg 96:1589-97, table of contents. 2003
    ..6 mm Hg for each milligram per liter. There was a larger reduction (2.5 mm Hg x mg(-1) x L(-1)) for the IV route. Therefore, this effect was predominantly mediated by propofol concentrations elsewhere in the body...
  80. ncbi Vasoconstrictor reserve and sympathetic neural control of orthostasis
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, Tex 75231, USA
    Circulation 110:2931-7. 2004
    ..We tested the hypothesis that individual variability in orthostatic tolerance is dependent on the degree of neural and vasomotor reserve available for vasoconstriction...
  81. ncbi Coronary sinus venoarterial CO2 difference in different hemodynamic states
    G Vretzakis
    University Hos of Alexandroupolis, Greece
    Acta Anaesthesiol Belg 55:221-7. 2004
    ..Under these circumstances, deltaP(cs-a)CO2 appears stable and is not suitable for clinical decisions concerning heart's coronary flow...
  82. ncbi Prolonged recirculation is required to detect secondary metabolic and hemodynamic deterioration after superior mesenteric artery occlusion
    Michael Lauterbach
    Institute for Neurosurgical Pathophysiology, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Clin Hemorheol Microcirc 32:1-12. 2005
    ..Prolonged observation periods are required to detect these significant changes which are overlooked when only studying 120 minutes of reperfusion as usually done...
  83. ncbi Maintained cardiac pumping in anoxic crucian carp
    Jonathan A W Stecyk
    Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby V5A 1S6, Canada
    Science 306:77. 2004
    ..These responses point to an unusual tolerance of a vertebrate heart and autonomic nervous system to prolonged anoxia...
  84. ncbi Normobaric hyperoxia reduces cardiac index in patients after coronary artery bypass surgery
    Johann M Harten
    Department of Anaesthesia, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom
    J Cardiothorac Vasc Anesth 19:173-5. 2005
    ..The purpose of this study was to assess the hemodynamic changes in response to normobaric hyperoxia in patients immediately after coronary artery bypass surgery...
  85. ncbi Central beta-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stress
    Ruth A Rauls
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Brain Res 1048:98-107. 2005
    ..The results suggest that startle elicits hemodynamic responses that are primarily dependent on beta1-adrenoceptors but responses to sustained stress are dependent on beta2-adrenoceptors in the CNS...
  86. ncbi The hemodynamic effect of calcium ion concentration in the infusate during predilution hemofiltration in chronic renal failure
    Nikolaos Karamperis
    Department of Renal Medicine C, Skejby, Aarhus University Hospital, Aarhus, Denmark
    Am J Kidney Dis 46:470-80. 2005
    ..The aim of this study is to investigate the influence of calcium ion concentration in the substitution fluid on hemodynamic stability during predilution hemofiltration (HF)...
  87. ncbi Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study
    Jacques Albanese
    Department of Intensive Care Medicine and Trauma Center, Hospital Nord, Marseille Cedex 20, France
    Crit Care Med 33:1897-902. 2005
    ..To compare, in patients with hyperdynamic septic shock, the effects of norepinephrine or terlipressin on hemodynamic variables and renal function...
  88. ncbi Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom EH16 4SB
    Arterioscler Thromb Vasc Biol 24:1043-8. 2004
    ..Using B9340, a bradykinin receptor antagonist, we determined the contribution of bradykinin to the systemic hemodynamic effects of long-term ACE inhibition in patients with chronic heart failure...
  89. ncbi [The effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption of dogs]
    Zao hua Zhang
    Institute of Traditional Chinese Medicine information, China Academy of Traditional Chinese Medicine, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 30:1001-5. 2005
    ..To study the effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption for analyzing its underlying mechanism in the treatment of coronary heart disease...
  90. ncbi Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levels
    Kazuki Nakajima
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu 514 0823, Japan
    Int J Cardiol 104:332-7. 2005
    ..Thus, ANP infusion may improve LV diastolic function even in patients with moderate heart failure and high plasma BNP levels...
  91. ncbi Exaggerated platelet and hemodynamic reactivity to mental stress in men with coronary artery disease
    Philip C Strike
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
    Psychosom Med 66:492-500. 2004
    ..This study compared the effects of acute mental stress on cardiovascular and subjective responses and platelet activation in male patients with established coronary artery disease (CAD) and age-matched controls...
  92. ncbi Improving hemodynamics by atrial pacing during off-pump bypass surgery
    Vassilios Gulielmos
    Department of Thoracic and Cardiovascular Surgery, Heart Center Dresden, University Hospital, Dresden, Germany
    Heart Surg Forum 6:E179-82. 2003
    ..To avoid hemodynamic deterioration during tilting of the heart in off-pump surgery, we perform atrial pacing. We describe hemodynamic evaluation of this simple maneuver...
  93. ncbi Central and peripheral hemodynamic effects of losartan and in combination with hydrochlorothiazide in mild to moderate essential hypertension
    Valery I Podzolkov
    Clinic of Internal Diseases, Sechenov Moscow Medical Academy, Moscow, Russia
    Blood Press 12:239-45. 2003
    ..We aimed to clarify the effects of losartan and its combination with hydrochlorothiazide on 24-h blood pressures (BPs), central hemodynamics and microcirculation in essential hypertension (EH)...
  94. ncbi Renal anemia and its hemodynamic response--findings invasively determined over a period of 20 years
    G E Schäfer
    Medical Hospital III, Clinic Offenbach am Main, Germany
    Clin Nephrol 58:S52-7. 2002
    ..Early correction of anemia seems to reduce the risk of fatal cardial complications and to improve the quality of life and the prognosis of pre-uremic patients...
  95. ncbi Regional hemodynamic effects of nociceptin/orphanin FQ in the anesthetized rat
    Aly M Abdelrahman
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Eur J Pharmacol 450:263-6. 2002
    ..Thus, nociceptin causes generalized vasodilatation; its greatest influence is on the skeletal muscle bed...
  96. ncbi The effect of profiled hemodialysis on intradialytic hemodynamics when a proper sodium balance is applied
    B Straver
    Department of Nephrology, Institute for Cardiovascular Research VU ICaR VU, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Blood Purif 20:364-9. 2002
    ..The present study investigated the effect of profiled HD, without an accompanying sodium loading, on intradialytic hemodynamics in stable HD patients...
  97. ncbi Hemodynamic responses to stress among black women: fitness and parental hypertension
    Erica M Jackson
    Department of Health and Human Performance, Auburn University, Auburn, AL 36849 5323
    Med Sci Sports Exerc 34:1097-104; discussion 1105. 2002
    ..We compared hemodynamic aspects of the relationship between cardiorespiratory fitness and blood pressure changes during and after laboratory stress in young black women with or without parental history of hypertension...
  98. ncbi Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog
    Kentaro Setoyama
    Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan
    J Vet Med Sci 64:499-503. 2002
    ..In addition, milrinone is very potent in improving severe congested hemodynamics which complicates hypoxic pulmonary vasoconstriction...
  99. ncbi The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in the perinatal lamb
    Yashu Coe
    Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Pharmacol Exp Ther 302:672-80. 2002
    ..We conclude that PD 156707 and PD 180988 are selective inhibitors of pulmonary vasoconstriction resulting from hypoxia. Our findings support the use of these or allied compounds in the management of pulmonary hypertension in the neonate...
  100. ncbi Thoracic sympathectomy: effects on hemodynamics and baroreflex control
    René Kingma
    Department of Anaesthesiology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Auton Res 12:35-42. 2002
    ..High frequency power of HR as well as baroreflex sensitivity, both parasympathetic markers, did not change in a statistically significant manner...
  101. ncbi Skin cooling maintains cerebral blood flow velocity and orthostatic tolerance during tilting in heated humans
    Thad E Wilson
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75321, USA
    J Appl Physiol 93:85-91. 2002
    ..Hence, skin-surface cooling may be a potent countermeasure to protect against orthostatic intolerance observed in heat-stressed humans...

Research Grants66

  1. Detecting Endothelial Dysfunction in Renal Failure
    Julian Stewart; Fiscal Year: 2007
    ..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
  2. ADVANCED OPTICAL IMAGE PROBE FOR NEUROPHYSIOLOGY
    David Rector; Fiscal Year: 2009
    ..Changes in light absorbance associated with metabolic and hemodynamic processes are robust and relatively easy to obtain non-invasively, but spatial and temporal resolution is limited by ..
  3. NOVEL METHODS FOR FUNCTIONAL BRAIN IMAGING
    CHRISTOPHER DECHARMS; Fiscal Year: 2005
    ..of activation that rely upon blood flow are inherently limited by the temporal and spatial scales of hemodynamic processes. Methods using electrical measurements (EEG) or magnetic measurements (MEG) are capable of high temporal ..
  4. CLINICAL APPLICATION OF END SYSTOLIC P-V RELATIONS
    Mark Starling; Fiscal Year: 2000
    ..of spherical geometry, and that surgery for LV volume overload at this time will reverse these detrimental hemodynamic processes and, thereby, preserve or restore normal LV size and performance...
  5. Nitric Oxide in Tumor Physiology: A Bioengineering Model
    JAMES BAISH; Fiscal Year: 2002
    ..Nitric oxide is involved in numerous vascular and hemodynamic processes in solid tumors that depend upon its local concentration...
  6. Neural and metabolic activity in vision and attention
    JACK GALLANT; Fiscal Year: 2005
    ..We propose to investigate the relationship between neural, metabolic and hemodynamic processes by use of a novel multispectral probe that allows simultaneous measurement of neural, metabolic and ..
  7. NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIA
    Shailendra Joshi; Fiscal Year: 2005
    ..abstract_text> ..
  8. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ....
  9. Genetic Risk Factors for Portopulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
  10. Neurohormonal Activation in Pulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..We will formulate prediction rules using neurohormone levels and clinical variables to improve prognostication and management in this disease. ..
  11. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  12. ACTION-A CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE
    William Abraham; Fiscal Year: 2005
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  13. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2008
    ..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..
  14. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  16. Bridge to neonatal Fontan repair of single ventricle
    Mark Rodefeld; Fiscal Year: 2006
    ..abstract_text> ..
  17. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2008
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  18. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2005
    ..This information will contribute to our understanding of predisposing factors to the incidence and severity of septic shock in humans and the mechanisms by which cocaine use affects this process. ..
  19. OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTION
    DANIEL KAPUSTA; Fiscal Year: 2003
    ..In summary, an RCDA will greatly enhance my research productivity and scientific career. ..
  20. CARDIOVASCULAR EFFECTS OF COCAINE
    MARK KNUEPFER; Fiscal Year: 2001
    ..Furthermore, our studies offer a novel model by which individuals at greater risk for cocaine- or stress-related heart disease may be identified. ..
  21. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  22. Neurovascular Factors in Functional MRI
    Thomas T Liu; Fiscal Year: 2010
    ..The specific aims of this project are to identify the measures that most effectively explain changes in resting-state connectivity due to (a) caffeine usage and (b) inter-subject differences in physiology. ..
  23. OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTION
    DANIEL KAPUSTA; Fiscal Year: 2007
    ..abstract_text> ..
  24. Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
    Mias Pretorius; Fiscal Year: 2010
    ..These studies promise to provide important information regarding the effects of drugs that interrupt the RAS and generate new strategies to reduce morbidity in patients undergoing CPB. ..
  25. Nanoscale approaches to allelic silencing in myocardial disease states
    Euan Ashley; Fiscal Year: 2009
    ..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..
  26. Chronic Stress or Psychostimulants on Central and Autonomic Nervous Systems
    Mark M Knuepfer; Fiscal Year: 2010
    ..The results will illuminate the similarities and differences in central autonomic and neuroendocrine responsiveness to stress and psychostimulants. ..
  27. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2008
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  28. PHARMACOLOGY OF COMBINED EPHEDRINE/CAFFEINE SUPPLEMENTS
    Christine Haller; Fiscal Year: 2004
    ..The long-term objective for the proposed studies is to develop Dr. Haller into an independent career clinical researcher in this field of study. ..
  29. Assessment of Muscle Vascular Disease with Diffuse Light
    Guoqiang Yu; Fiscal Year: 2007
    ..The proposed, noninvasive, portable, and inexpensive optical technology may fill in this gap by providing multiple hemodynamic information and by enabling continuous measurements at the bed-side and in ambulatory care. ..
  30. PEDIATRIC CARDIOMYOPATHY REGISTRY
    Steven Lipshultz; Fiscal Year: 2009
    ..These studies will dramatically increase our understanding of pediatric cardiomyopathy, suggest new areas of research and improved patient management. ..
  31. Functional Relevance of Spontaneous BOLD Fluctuations
    Michael Fox; Fiscal Year: 2008
    ..Further, the functional relevance of spontaneous BOLD fluctuations is important for understanding reported disturbances in these fluctuations in different pathological conditions. ..
  32. Full Head, High Density Functional Diffuse Optical Tomography
    Joseph Culver; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. ANP Modulates Cardiac Remodeling via Cardiac Fibroblasts
    Yiu Fai Chen; Fiscal Year: 2009
    ..These mechanistic studies will provide a more rational basis for therapeutic intervention in patients with cardiac dysfunction/failure, many of whom have decreased levels of ANP. ..
  34. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  35. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  36. Effect of Adenosine A2 receptor activation on the mitochondrial death pathway
    Zhelong Xu; Fiscal Year: 2010
    ....
  37. Vascular Mechanisms of Cerebral Ischemic Tolerance
    JEFFREY GIDDAY; Fiscal Year: 2008
    ..abstract_text> ..
  38. Regulation of H/K-ATPase in Kidney and Colon
    BRUCE KONE; Fiscal Year: 2009
    ..abstract_text> ..
  39. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  40. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  41. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  42. INTEGRATIVE ASPECTS OF CARDIOVASCULAR FUNCTION
    Don Sheriff; Fiscal Year: 2005
    ....
  43. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  44. Modulatory Effect of Acupuncture on Human Brain Activity
    Kathleen Hui; Fiscal Year: 2003
    ..abstract_text> ..
  45. CRANIOFACIAL MORPHOGENESIS IN PRENATAL ALCOHOL EXPOSURE
    Susan Smith; Fiscal Year: 2005
    ..Results also may provide possible explanations for genetic-based variations in fetal responses to prenatal ethanol exposure. ..
  46. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..We anticipate that the study findings will suggest the use of new evaluation and therapeutic strategies, which will significantly decrease the age associated mortality and morbidity in post-infarction patients. ..
  47. Mixed-Effects ZIP Models--Mental Health Service Research
    Robert Gibbons; Fiscal Year: 2004
    ..abstract_text> ..
  48. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  49. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  50. INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASE
    John Kinsella; Fiscal Year: 2004
    ..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
  51. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  52. Diastolic Dysfunction & Atrial Fibrillation in Elderly
    TERESA TSANG; Fiscal Year: 2007
    ..Identification of the cascade of factors contributing to AF development will have important implications in primary prevention of this major public health problem. ..
  53. Psychopharmacology of Autism and related Disorders
    David Posey; Fiscal Year: 2007
    ..Towards the later years of the award, the candidate will have performed additional studies and applied for independent research funding. ..
  54. REGIONAL BETA ADRENERGIC DURING LV REMODELING
    Christopher Kramer; Fiscal Year: 2002
    ..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
  55. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..Pilot data (n=12) towards this proposal suggests that glycine reduces ketamine-induced perceptual alterations, negative symptoms and impairments on recall without worsening positive symptoms. ..
  56. SERCA2a Abnormalities and Chaperones in Heart Failure
    Federica Del Monte; Fiscal Year: 2006
    ..abstract_text> ..
  57. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2006
    ..This study will determine the cardiovascular effects of HAART in seroreverters and the need for future cardiovascular follow-up and cardiovascular preventive and therapeutic trials in this rapidly expanding population. ..
  58. Nitric oxide and superoxide effects on the failing heart
    Yingjie Chen; Fiscal Year: 2006
    ..Additional studies will determine whether mRNA and protein expression and activity for eNOS, nNOS, iNOS, CuZn-SOD, Mn-SOD and Ec-SOD are altered in coronary vessels and myocardium by the presence of CHF. ..
  59. Multi-photon and fluorescence-lifetime microscope for in-vivo functional imaging
    David Boas; Fiscal Year: 2006
    ..This system will be an invaluable resource for the many interdisciplinary research projects within the Martinos center, in the surrounding MGH community, and for many others in the greater Boston area. [unreadable] [unreadable]..
  60. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  61. Controlled-Release HIF-1 Delivery for Arteriogenesis
    Lawrence Hofmann; Fiscal Year: 2005
    ..These projects and career development plans will provide the resources, collaborative relationships, and academic foundation of which the candidate will build a successful career as an independent clinical scientist. ..
  62. fMRI and TMS of Motor Recovery after Hemiparetic Stroke
    Judith Schaechter; Fiscal Year: 2007
    ..abstract_text> ..
  63. ATRIAL NATRIURETIC PEPTIDE AND RECEPTOR GENES IN HYPOXIA
    Yiu Fai Chen; Fiscal Year: 2010
    ..Our proposed mechanistic studies will lead to innovative and effective therapeutic approaches to this important cause of morbidity and mortality in the American population. ..
  64. Novel epoxide hydrolase inhibitor for stroke prevention
    JOHN IMIG; Fiscal Year: 2005
    ..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
  65. PRICE: Pivotal Research in Cardiology in the Elderly
    Michael Rich; Fiscal Year: 2008
    ....
  66. HEMORHEOLOGY STUDIES RELATED TO IN VIVO BLOOD FLOW
    HERBERT MEISELMAN; Fiscal Year: 2008
    ....