renal circulation

Summary

Summary: The circulation of the BLOOD through the vessels of the KIDNEY.

Top Publications

  1. ncbi MRI-measurement of perfusion and glomerular filtration in the human kidney with a separable compartment model
    Steven P Sourbron
    Institute of Clinical Radiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Invest Radiol 43:40-8. 2008
  2. pmc Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys
    Nathan S Artz
    Department of Medical Physics, University of Wisconsin Madison, Wisconsin Institute for Medical Research, Madison, WI 53705 2275, USA
    Magn Reson Imaging 29:74-82. 2011
  3. ncbi Renal blood flow in experimental septic acute renal failure
    C Langenberg
    Department of Nephrology, Charite Campus Mitte, Berlin, Germany
    Kidney Int 69:1996-2002. 2006
  4. ncbi Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI
    Jeff D Winter
    Research Institute, Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 34:608-15. 2011
  5. ncbi Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats
    Laura G Sanchez-Lozada
    Dept of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1 14080, Mexico City, Mexico
    Am J Physiol Renal Physiol 292:F423-9. 2007
  6. ncbi Renal perfusion 3-T MR imaging: a comparative study of arterial spin labeling and dynamic contrast-enhanced techniques
    Wen Chau Wu
    Graduate Institute of Oncology, National Taiwan University, No 1, Sec 1, Ren Ai Rd, Taipei 100, Taiwan
    Radiology 261:845-53. 2011
  7. ncbi Anteroventral third ventricle lesions impair cardiovascular responses to intravenous hypertonic saline infusion
    Gustavo Rodrigues Pedrino
    Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Auton Neurosci 117:9-16. 2005
  8. ncbi Blood oxygen level-dependent measurement of acute intra-renal ischemia
    Laurent Juillard
    Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 65:944-50. 2004
  9. ncbi Rapid microplate method for PAH estimation
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 283:F236-41. 2002
  10. ncbi Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 43:752-9. 2004

Research Grants

  1. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
  2. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
  3. KIDNEY DISEASE RESEARCH TRAINING PROGRAM
    John C Lieske; Fiscal Year: 2012
  4. RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    Holly Middlekauff; Fiscal Year: 2000
  5. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 1999
  6. REGULATION OF RENAL CIRCULATION
    DONALD MARSH; Fiscal Year: 1990
  7. Non-linear regulation of the renal circulation
    DONALD MARSH; Fiscal Year: 2007
  8. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
  9. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
  10. Reactive Oxygen Species American Society of Nephrology Fall 2007
    THOMAS PALLONE; Fiscal Year: 2007

Detail Information

Publications249 found, 100 shown here

  1. ncbi MRI-measurement of perfusion and glomerular filtration in the human kidney with a separable compartment model
    Steven P Sourbron
    Institute of Clinical Radiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Invest Radiol 43:40-8. 2008
    ..In this study, the feasibility of the separable compartment model for the measurement of perfusion and filtration in healthy humans is investigated...
  2. pmc Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys
    Nathan S Artz
    Department of Medical Physics, University of Wisconsin Madison, Wisconsin Institute for Medical Research, Madison, WI 53705 2275, USA
    Magn Reson Imaging 29:74-82. 2011
    ..To apply a magnetic resonance arterial spin labeling (ASL) technique to evaluate kidney perfusion in native and transplanted kidneys...
  3. ncbi Renal blood flow in experimental septic acute renal failure
    C Langenberg
    Department of Nephrology, Charite Campus Mitte, Berlin, Germany
    Kidney Int 69:1996-2002. 2006
    ..05). After 24 h, urine output decreased from 1.4 to 0.3 ml/kg/h (P<0.05). Infusion of E. coli induced hyperdynamic sepsis and ARF. Septic ARF in this setting was associated with a marked increase in RBF and with renal vasodilatation...
  4. ncbi Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI
    Jeff D Winter
    Research Institute, Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 34:608-15. 2011
    ..Moreover, we provide the first application of the dual bolus approach to quantitative DCE-MRI perfusion measurements in the kidney...
  5. ncbi Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats
    Laura G Sanchez-Lozada
    Dept of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1 14080, Mexico City, Mexico
    Am J Physiol Renal Physiol 292:F423-9. 2007
    ..These changes are best observed in rats administered high doses (60% diet) of fructose...
  6. ncbi Renal perfusion 3-T MR imaging: a comparative study of arterial spin labeling and dynamic contrast-enhanced techniques
    Wen Chau Wu
    Graduate Institute of Oncology, National Taiwan University, No 1, Sec 1, Ren Ai Rd, Taipei 100, Taiwan
    Radiology 261:845-53. 2011
    ..To investigate the feasibility of and correlation between arterial spin-labeling (ASL) and dynamic contrast material-enhanced (DCE) 3-T magnetic resonance (MR) imaging in the measurement of renal blood flow (RBF)...
  7. ncbi Anteroventral third ventricle lesions impair cardiovascular responses to intravenous hypertonic saline infusion
    Gustavo Rodrigues Pedrino
    Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Auton Neurosci 117:9-16. 2005
    ..These results demonstrate that integrity of the AV3V region is essential for the renal vasodilation that follows acute changes in extracellular fluid compartment composition...
  8. ncbi Blood oxygen level-dependent measurement of acute intra-renal ischemia
    Laurent Juillard
    Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 65:944-50. 2004
    ..This study was therefore designed to test if BOLD can detect the characteristic of renal hypoxia induced by RAS...
  9. ncbi Rapid microplate method for PAH estimation
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 283:F236-41. 2002
    ..The microplate method is a reliable alternative to a reference HPLC method and can be performed for a fraction of the cost, time, and reagents...
  10. ncbi Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 43:752-9. 2004
    ..We conclude that the preferential juxtamedullary injury found in Ang II hypertension is largely induced by pressure and is probably mediated through the TGF-beta and NF-kappaB pathway...
  11. ncbi Production and actions of superoxide in the renal medulla
    A P Zou
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Hypertension 37:547-53. 2001
    ..is primarily produced in the renal OM; (2) both NADH oxidase and mitochondrial enzymes are responsible for the O(2)(-.)production in this kidney region; and (3) O(2)(-. )exerts a tonic regulatory action on renal MBF...
  12. ncbi Role of renal medullary adenosine in the control of blood flow and sodium excretion
    A P Zou
    Departments of Physiology and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 276:R790-8. 1999
    ....
  13. ncbi Role of catecholaminergic neurones of the caudal ventrolateral medulla in cardiovascular responses induced by acute changes in circulating volume in rats
    Gustavo Rodrigues Pedrino
    Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Exp Physiol 91:995-1005. 2006
    ..These results suggest that catecholaminergic neurones mediate the cardiovascular responses to VE or increases in plasma sodium levels...
  14. ncbi Renal vasodilation induced by hypernatraemia: role of alpha-adrenoceptors in the median preoptic nucleus
    Gustavo R Pedrino
    Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 36:e83-9. 2009
    ..5. The results of the present study demonstrate that the integrity of adrenergic neurotransmission in the MnPO is essential for the renal vasodilation that follows acute increases in blood sodium concentration...
  15. ncbi Impact of hyperglycemia on the renin angiotensin system in early human type 1 diabetes mellitus
    J A Miller
    Department of Medicine, University of Toronto, Ontario, Canada
    J Am Soc Nephrol 10:1778-85. 1999
    ....
  16. ncbi Determinants of glomerular hypofiltration in aging humans
    Khoi Hoang
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Kidney Int 64:1417-24. 2003
    ..The purpose of the present study was to confirm the extent to which glomerular filtration rate (GFR) is depressed in healthy, aging subjects and to elucidate the mechanism of such hypofiltration...
  17. pmc Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension
    Gina M Warner
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 302:F1455-64. 2012
    ..We conclude that abrogation of TGF-β/Smad3 signaling confers protection against the development of fibrosis and atrophy in RAS...
  18. pmc Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys
    Min Xia
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 329:1056-62. 2009
    ..These results suggest that H(2)S participates in the control of renal function and increases urinary sodium excretion via both vascular and tubular actions in the kidney...
  19. ncbi Quantification of renal perfusion and function on a voxel-by-voxel basis: a feasibility study
    M Dujardin
    Department of Radiology, Vrije Universiteit Brussel BEFY, Belgium
    Magn Reson Med 54:841-9. 2005
    ....
  20. ncbi Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep
    Reetu R Singh
    Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia
    Clin Sci (Lond) 118:669-80. 2010
    ..This suggests that people born with a nephron deficit should be monitored for early signs of renal and cardiovascular disease...
  21. ncbi Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow
    Paul M O'Connor
    Dept of Physiology, Medical College of Wisconsin, 8071 Watertown Plank Road, Milwaukee, WI 53266, USA
    Am J Physiol Renal Physiol 290:F688-94. 2006
    ..Thus, although cortical and medullary blood flow may be independently regulated, medullary oxygenation may be compromised during moderate to severe cortical ischemia even when medullary blood flow is maintained...
  22. ncbi Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis
    Roger G Evans
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    Am J Physiol Renal Physiol 295:F1259-70. 2008
    ..To fully understand the control of renal oxygenation, we must consider a triad of factors that regulate intrarenal oxygenation: local perfusion, local Vo2, and AV oxygen shunting...
  23. pmc Improved renal perfusion measurement with a dual navigator-gated Q2TIPS fair technique
    Ruitian Song
    Department of Radiological Sciences, Division of Translational Imaging Research, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    Magn Reson Med 64:1352-9. 2010
    ..The proposed technique may prove most beneficial for noncontrast-based renal perfusion quantification in young children and patients who may have difficulty holding their breath for prolonged periods or are sedated/anesthetized...
  24. ncbi Renal ageing
    J E Martin
    Pathology Group, Institute of Cell and Molecular Sciences, St Bartholomew s and the London Hospital School of Medicine and Dentistry, London, UK
    J Pathol 211:198-205. 2007
    ....
  25. pmc Renal blood flow in sepsis
    Christoph Langenberg
    Department of Intensive Care, Austin Hospital, and University of Melbourne, Heidelberg, Melbourne, Australia
    Crit Care 9:R363-74. 2005
    ..To assess changes in renal blood flow (RBF) in human and experimental sepsis, and to identify determinants of RBF...
  26. pmc Intrinsic nitric oxide and superoxide production regulates descending vasa recta contraction
    Chunhua Cao
    Div of Nephrology, N3W143, 22 S Greene St, UMMS, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 299:F1056-64. 2010
    ..Intrinsic NO production does not affect DVR permeability to hydrophilic solutes...
  27. ncbi Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat
    David W Stepp
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Heart Circ Physiol 293:H2537-42. 2007
    ..This increased reactivity to ANG II may explain the elevated renal vasodilator effects observed in obese humans and provide insight into early changes in renal function that predispose to nephropathy in later stages of the disease...
  28. ncbi CT angiography of the renal circulation
    Peter S Liu
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109 0030, USA
    Radiol Clin North Am 48:347-65, viii-ix. 2010
    ..This article describes the technical considerations relevant to CTA of the renal vascular system, postprocessing algorithms for volumetric data, and numerous specific applications...
  29. ncbi Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles
    K Kohagura
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University School of Medicine, Sendai, Japan
    Hypertens Res 24:551-7. 2001
    ..Further, it appears that the CYP450 epoxygenase pathway attenuates Ang II action via AT2 receptors...
  30. ncbi Assessment of renal autoregulation
    William A Cupples
    Centre for Biomedical Research and Dept of Biology, Univ of Victoria, PO Box 3020, STN CSC, Victoria, BC, Canada
    Am J Physiol Renal Physiol 292:F1105-23. 2007
    ..We consider the modulation of autoregulation by nitric oxide and use it to illustrate the necessity for multiple experimental designs, often applied iteratively...
  31. pmc Effects of renal perfusion pressure on renal medullary hydrogen peroxide and nitric oxide production
    Chunhua Jin
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 53:1048-53. 2009
    ..The parallel pressure-induced increases of H(2)O(2) and NO indicate a participation in shaping the "normal" pressure-natriuresis relationship and explain why an imbalance in either would affect the blood pressure salt sensitivity...
  32. ncbi Measurement of renal volumes with contrast-enhanced MRI
    Curtis H Coulam
    Department of Radiology, Stanford University School of Medicine, Stanford, California 94205, USA
    J Magn Reson Imaging 15:174-9. 2002
    ..To determine the accuracy of in vivo magnetic resonance imaging (MRI) measurement of total renal parenchymal volume and medullary fraction. MATERIALS and..
  33. ncbi Direct in vivo visualization of glomerular microcirculation by intravital pencil lens-probe CCD videomicroscopy
    T Yamamoto
    Department of Urology, Kawasaki Medical School, Okayama, Japan
    Clin Hemorheol Microcirc 23:103-8. 2000
    ..In conclusion, this novel technique is a valuable tool for unveiling the in vivo, in situ, and intact renal microvascular behavior, and may provide further approaches to the understanding of renal microcirculation...
  34. ncbi A feasibility study on model-based evaluation of kidney perfusion measured by means of FAIR prepared true-FISP arterial spin labeling (ASL) on a 3-T MR scanner
    Claus Kiefer
    Department of Angiology, Institute for Diagnostic and Interventional Neuroradiology, University Hospital Berne and University of Berne, Berne, Switzerland
    Acad Radiol 16:79-87. 2009
    ..A feasibility study on measuring kidney perfusion by a contrast-free magnetic resonance (MR) imaging technique is presented...
  35. ncbi Neural control of renal medullary perfusion
    Gabriela A Eppel
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 31:387-96. 2004
    ..Failure of these mechanisms would promote reductions in MBF in response to physiological activation of the renal nerves, which could, in turn, lead to salt and water retention and hypertension...
  36. ncbi Autoregulation of renal medullary blood flow in rabbits
    Gabriela A Eppel
    Department of Physiology, Monash University, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 284:R233-44. 2003
    ..These data do not, however, exclude the possibility that MBF is increased with increasing RAP in this model, because vasa recta recruitment may occur...
  37. ncbi Pericyte regulation of renal medullary blood flow
    T L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Exp Nephrol 9:165-70. 2001
    ..Known vasoconstrictors of DVR include angiotensin II, endothelins, norepinephrine, acetylcholine, and adenosine. Vasodilators include prostaglandin E2, adenosine, acetylcholine, bradykinin, and nitric oxide...
  38. ncbi Function of connexins in the renal circulation
    C Wagner
    Physiologisches Institut der Universität Regensburg, Regensburg, Germany
    Kidney Int 73:547-55. 2008
    ..This review focuses on the significance of connexins in the renal circulation. Cells of the renal vasculature are coupled and express connexins in a vessel and cell-specific pattern...
  39. ncbi Responses to acute changes in arterial pressure on renal medullary nitric oxide activity in dogs
    D S Majid
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hypertension 34:832-6. 1999
    ..These data support the hypothesis that acute changes in RAP elicit changes in intrarenal NO production, which may participate in the mediation of pressure natriuresis...
  40. ncbi The effect of the sample size and location on contrast ultrasound measurement of perfusion parameters
    Merja R Leinonen
    Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P O Box 57, Helsinki 00014, Finland
    Vet Radiol Ultrasound 52:82-7. 2011
    ..When comparing two different ROIs in a patient with focal lesions, such as suspected neoplasia or infarction, the ROIs should always be placed at same depth and be as similar in size as possible...
  41. ncbi Long-term alteration in maternal blood pressure and renal function after pregnancy in normal and growth-restricted rats
    Linda A Gallo
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    Hypertension 60:206-13. 2012
    ..Our results have implications for aging females who have been pregnant, suggesting long-term cardiovascular and renal alterations, with additional consequences for females who were small at birth...
  42. ncbi Role of nitric oxide in regulation of the renal medulla in normal and hypertensive kidneys
    Thomas L Pallone
    Department of Medicine, Nephrology Division, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Nephrol Hypertens 11:93-8. 2002
    ..The likelihood that some forms of hypertension result directly from pathological alteration of transporters, channels, regulatory elements or enzymes that affect medullary nitric oxide seems high...
  43. ncbi Kidney modeling and systems physiology
    S Randall Thomas
    IBISC CNRS FRE 3190 and University of Evry, Tour Evry 2, 91000 Evry, France
    Wiley Interdiscip Rev Syst Biol Med 1:172-90. 2009
    ....
  44. ncbi Localization of prostaglandin E(2) EP2 and EP4 receptors in the rat kidney
    B L Jensen
    Department of Physiology and Pharmacology, University of Southern Denmark Odense, DK 5000 Odense C, Denmark
    Am J Physiol Renal Physiol 280:F1001-9. 2001
    ..These results suggest that PGE(2) may act in the resistance vessels and in the DTL and DCT-CCD segments as a paracrine, cAMP-dependent regulator of vascular resistance and tubular transport, respectively...
  45. pmc Comparing kidney perfusion using noncontrast arterial spin labeling MRI and microsphere methods in an interventional swine model
    Nathan S Artz
    Department of Medical Physics, Wisconsin Institute for Medical Research, University of Wisconsin Madison, 1111 Highland Ave, Madison, WI 53705, USA
    Invest Radiol 46:124-31. 2011
    ....
  46. ncbi ETA receptors mediate vasoconstriction, whereas ETB receptors clear endothelin-1 in the splanchnic and renal circulation of healthy men
    Felix Bohm
    Department of Cardiology, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Clin Sci (Lond) 104:143-51. 2003
    ..The ET(B) receptor seems to function as a clearance receptor and may modulate vascular tone by altering the plasma concentration of ET-1...
  47. ncbi Mechanisms of pressure natriuresis
    Joey P Granger
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Curr Hypertens Rep 4:152-9. 2002
    ....
  48. ncbi Inner medullary lactate production and urine-concentrating mechanism: a flat medullary model
    Stéphane Hervy
    Institut National de la Santé et de la Recherche Médicale Unit 467, Necker Faculty of Medicine, University of Paris 5, France
    Am J Physiol Renal Physiol 284:F65-81. 2003
    ....
  49. pmc Blood oxygen level-dependent magnetic resonance imaging identifies cortical hypoxia in severe renovascular disease
    Monika L Gloviczki
    Department of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 58:1066-72. 2011
    ..The level of cortical hypoxia is out of proportion to the medulla and may provide a marker to identify irreversible parenchymal injury...
  50. ncbi Role of L-arginine uptake mechanisms in renal blood flow responses to angiotensin II in rats
    N W Rajapakse
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Acta Physiol (Oxf) 203:391-400. 2011
    To examine whether reduced renal arginine transport increases the responsiveness of the renal circulation to angiotensin II in salt sensitivity, renal perfusion responses to angiotensin II were examined in the presence of L-arginine ..
  51. ncbi Intrarenal blood flow: microvascular anatomy and the regulation of medullary perfusion
    T L Pallone
    Division of Nephrology, University of Maryland at Baltimore, USA
    Clin Exp Pharmacol Physiol 25:383-92. 1998
    ..3. Vasoactive hormones that regulate smooth muscle cells of the renal circulation can originate outside the kidney (e.g...
  52. ncbi Dynamic myogenic autoregulation in the rat kidney: a whole-organ model
    N Kleinstreuer
    Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand 8140
    Am J Physiol Renal Physiol 294:F1453-64. 2008
    ..The model provides a basis for examining the steady state and transient characteristics of the whole-organ renal myogenic response in the rat, as well as the modulatory influences of metabolic and hemodynamic factors...
  53. ncbi Quantitative contrast ultrasound analysis of renal perfusion in normal dogs
    Kenneth R Waller
    Department of Surgical Sciences, University of Wisconsin Madison, Madison, WI, USA
    Vet Radiol Ultrasound 48:373-7. 2007
    ..2 +/- 14.3 MPV, time to peak from injection was 20.9 +/- 6.4 s and from time of contrast reaching the kidney was 11.6 +/- 4.1 s. These baseline data may prove useful in the evaluation of dogs with diffuse disease or vascular compromise...
  54. ncbi The regulation of blood perfusion in the renal cortex and medulla by reactive oxygen species and nitric oxide in the anaesthetised rat
    A F Ahmeda
    Department of Physiology, University College Cork, Ireland
    Acta Physiol (Oxf) 204:443-50. 2012
    ..This investigation examined the hypothesis that reactive oxygen species has both direct and indirect actions, via scavenging NO, to determine the degree of blood perfusion through the renal medulla...
  55. ncbi Control of the renal medullary circulation by vasopressin V1 and V2 receptors in the rat
    A W Cowley
    Department Physiology, Medical College of Wisconsin, Milwaukee, USA
    Exp Physiol 85:223S-231S. 2000
    ..These changes are essential to provide a constancy of blood flow to the renal medulla and buffer against the hypertensive actions of this potent vasoconstrictor peptide...
  56. ncbi Renal hemodynamics and oxygenation in transient renal artery occluded rats evaluated with iron-oxide particles and oxygenation-sensitive imaging
    Michael Pedersen
    MR Research Centre, Aarhus University Hospital, Aarhus, Denmark
    Z Med Phys 20:134-42. 2010
    ....
  57. ncbi Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Adv Exp Med Biol 618:85-99. 2007
    ..This has given hope for the development of novel therapeutic approaches against hypoxia in the kidney...
  58. ncbi Effects of ET(A) - and ET(B)-receptor antagonists on regional kidney blood flow, and responses to intravenous endothelin-1, in anaesthetized rabbits
    R G Evans
    Department of Physiology, Monash University, Victoria, Australia
    J Hypertens 19:1789-99. 2001
    ..To determine the roles of endothelin (ET)-receptor subtypes in the effects of exogenous and endogenous ETs on regional kidney blood flow in anaesthetized rabbits...
  59. ncbi Alpha1B-adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment
    Md Abdul Hye Khan
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
    Acta Pharmacol Sin 29:193-203. 2008
    ..This study examined whether alpha1B-adrenoceptors are involved in mediating adrenergically-induced renal vasoconstrictor responses in rats with pathophysiological and normal physiological states...
  60. ncbi Inhibition of Ang II and renal sympathetic nerve influence dopamine-and isoprenaline-induced renal haemodynamic changes in normal Wistar-Kyoto and spontaneously hypertensive rats
    M H Abdulla
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
    Auton Autacoid Pharmacol 28:95-101. 2008
    ..Our observations reveal a possible relationship between renal AT(1) receptors and alpha(1)-adrenoceptors in WKY and SHR. There is also evidence to suggest an interaction between renal beta-adrenoceptors and AT(1) receptors in WKY rats...
  61. pmc Effects of pH and medullary blood flow on oxygen transport and sodium reabsorption in the rat outer medulla
    Jing Chen
    Department of Mathematics, Duke University, Durham, North Carolina, USA
    Am J Physiol Renal Physiol 298:F1369-83. 2010
    ..That is, at a sufficiently high medullary O(2) supply, O(2) demand in the outer medulla does not adjust precisely to changes in O(2) delivery...
  62. ncbi Effect of acute unilateral renal denervation on renal hemodynamics in spontaneously hypertensive rats
    M H Abdulla
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia
    Auton Autacoid Pharmacol 28:87-94. 2008
    ..These data also suggested a possible interaction between sympathetic nervous system and renin-angiotensin system in terms of a crosstalk relationship between renal AT(1) and alpha(1)-adrenoceptor subtypes...
  63. ncbi Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice
    Janice Schildroth
    Institute of Vegetative Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Nephrol Dial Transplant 26:779-89. 2011
    ..Endothelin 1 contributes to renal blood flow control and pathogenesis of kidney diseases. The differential effects, however, of endothelin 1 (ET-1) on afferent (AA) and efferent arterioles (EA) remain to be established...
  64. ncbi Programming of adult blood pressure by maternal protein restriction: role of nephrogenesis
    Lori L Woods
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon 97239, USA
    Kidney Int 65:1339-48. 2004
    ..This study determined whether a more severe protein restriction has equivalent effects on male and female rat offspring, and examined the role of nephrogenesis in this programming...
  65. ncbi Free-breathing renal MR angiography with steady-state free-precession (SSFP) and slab-selective spin inversion: initial results
    Marcus Katoh
    Department of Diagnostic Radiology, University Hospital, University of Technology, Aachen, Germany
    Kidney Int 66:1272-8. 2004
    ....
  66. ncbi The effect of oral contraceptives on the nitric oxide system and renal function
    D Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto
    Am J Physiol Renal Physiol 293:F1539-44. 2007
    ..04). In summary, these findings suggest that the NO system is upregulated by OC use in young, healthy women. Increased activity of the NO pathway may modulate the hemodynamic effects of RAS activation in OC users...
  67. ncbi Body mass index and angiotensin-dependent control of the renal circulation in healthy humans
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:1316-20. 2005
    ..The strong association between increasing body mass index and angiotensin-dependent control of the renal circulation suggests that this may be a mechanism by which obesity contributes to renal disease...
  68. ncbi Effect of oral contraceptives on the renin angiotensin system and renal function
    A K Kang
    Department of Medicine, University of Toronto, Toronto, Canada M5S 1A1
    Am J Physiol Regul Integr Comp Physiol 280:R807-13. 2001
    ..We conclude that the RAS is activated in women using OCs. There was no evidence that decreases in renin secretion result in normalization of the RAS as a whole...
  69. ncbi Physiology of the renal medullary microcirculation
    Thomas L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Am J Physiol Renal Physiol 284:F253-66. 2003
    ..To optimize urea trapping, DVR endothelia express the UT-B facilitated urea transporter. These and other features show that vasa recta have physiological mechanisms specific to their role in the renal medulla...
  70. ncbi Intrarenal blood flow distribution in hyperdynamic septic shock: Effect of norepinephrine
    David Di Giantomasso
    Department of Medicine, Melbourne University Austin and Repatriation Medical Centre, Heidelberg, Australia
    Crit Care Med 31:2509-13. 2003
    ..To measure changes in medullary and cortical renal blood flow during experimental hyperdynamic sepsis and the effect of subsequent norepinephrine infusion on such flows. DESIGN Experimental animal study...
  71. ncbi Nitric oxide in unilateral ureteral obstruction: effect on regional renal blood flow
    N J Hegarty
    Department of Surgery, Mater Misericordiae Hospital and University College Dublin, Dublin, Ireland
    Kidney Int 59:1059-65. 2001
    ..CONCLUSIONS: NO plays a vasodilatory role even in the hypoperfusion of prolonged UO. The administration of exogenous nitrates has a restorative effect on blood flow, suggesting therapeutic potential in UO...
  72. ncbi Intraindividual comparison of MR-renal perfusion imaging at 1.5 T and 3.0 T
    Henrik J Michaely
    Department of Clinical Radiology, University Hospitals Grosshadern, Ludwig Maximilians University Munich, Germany
    Invest Radiol 42:406-11. 2007
    ..The purpose of this study was to intraindividually compare fast gradient-echo semiquantitative renal perfusion measurements at 1.5 Tesla (T) and 3.0 Tesla...
  73. ncbi Oral contraceptives, angiotensin-dependent renal vasoconstriction, and risk of diabetic nephropathy
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, PBB 3, 75 Francis St, Boston, MA 02115, USA
    Diabetes Care 28:1988-94. 2005
    ..RAS activation occurs in healthy women using oral contraceptives (OCs), but the effects of OC use on the diabetic kidney are unclear...
  74. ncbi Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II
    Magdalena Alonso-Galicia
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 59226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R60-8. 2002
    ....
  75. ncbi Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Am Soc Nephrol 10:S258-65. 1999
    ..Blockade of the RAS has proved to be a powerful therapeutic tool for lowering BP and improving kidney function in disorders such as hypertension, congestive heart failure, and chronic renal disease...
  76. ncbi Comprehensive MR evaluation of renal disease: added clinical value of quantified renal perfusion values over single MR angiography
    Ulrike I Attenberger
    Department of Clinical Radiology, University Hospitals Munich Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Magn Reson Imaging 31:125-33. 2010
    ..To evaluate the diagnostic accuracy of quantified renal perfusion parameters in identifying and differentiating renovascular from renal parenchymal disease...
  77. ncbi Acute renal failure
    Norbert Lameire
    Renal Division, Department of Medicine, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
    Lancet 365:417-30. 2005
    ..Finally, some information on the influence of gene polymorphisms on the prognosis of acute renal failure is given...
  78. ncbi Renal artery stenosis: functional assessment with dynamic MR perfusion measurements--feasibility study
    Henrik J Michaely
    Institute of Clinical Radiology, University Hospitals Grosshadern, Department of Internal Medicine, Division of Nephrology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Radiology 238:586-96. 2006
    ..To prospectively assess feasibility of renal magnetic resonance (MR) perfusion measurement method based on turbo fast low-angle shot sequences for grading effect of renal artery stenosis (RAS) on parenchymal perfusion...
  79. ncbi Renal vascular responses to captopril and to candesartan in patients with type 1 diabetes mellitus
    M C Lansang
    Department of Medicine, Brigham and Women's Hospital, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 59:1432-8. 2001
    ..The high correlation between the renal hemodynamic response to captopril and to candesartan indicates that reduced angiotensin II formation is the main mechanism of action of the ACE inhibitor...
  80. ncbi The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia
    R Frithiof
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Anaesthesiol Scand 55:401-10. 2011
    ..It has been suggested to have beneficial anti-inflammatory properties and to protect kidney function. Here, we investigated the effect of isoflurane on the development of kidney injury and dysfunction during 48-h endotoxemia in sheep...
  81. ncbi Effect of angiotensin II antagonist eprosartan on hyperglycemia-induced activation of intrarenal renin-angiotensin system in healthy humans
    S Y Osei
    Departments of Medicine and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hypertension 36:122-6. 2000
    ..The enhancement of the renal vasodilator effect of eprosartan during hyperglycemia is consistent with activation of the intrarenal renin-angiotensin system...
  82. ncbi Hyperglycemia and angiotensin-mediated control of the renal circulation in healthy humans
    S Y Osei
    Department of Medicine and Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 33:559-64. 1999
    ..PRA did not change with hyperglycemia. Enhancement of renal vasodilation during hyperglycemia by captopril without alteration of PRA suggests activation of the intrarenal renin angiotensin system...
  83. ncbi Influence of sympathetic and AT-receptor blockade on angiotensin II and adrenergic agonist-induced renal vasoconstrictions in spontaneously hypertensive rats
    M H Abdulla
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
    Acta Physiol (Oxf) 195:397-404. 2009
    ..This study investigated the influence of angiotensin II (Ang II) receptor and adrenergic blockade on the renal vasoconstrictions caused by Ang II and adrenergic agonists in spontaneously hypertensive rats (SHR)...
  84. ncbi The isolated perfused rat kidney model: a useful tool for drug discovery and development
    David R Taft
    Division of Pharmaceutics and Industrial Pharmacy, Long Island University, 75 DeKalb Avenue, Brooklyn, NY 11201, USA
    Curr Drug Discov Technol 1:97-111. 2004
    ..Lastly, the role of IPK studies in drug development is discussed. Demonstrated correlations between IPK data and clinical outcomes make the IPK model a potentially useful tool for drug discovery and evaluation...
  85. ncbi Endothelin B receptors preserve renal blood flow in a normotensive model of endotoxin-induced acute kidney dysfunction
    Nicoletta Nitescu
    Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, The Sahlgrenska Academy at Goteborg University, Sweden
    Shock 29:402-9. 2008
    ..05]) in BQ-123-treated rats but did not significantly influence MAP in other groups. We conclude that in early normotensive endotoxemia, ETB receptors exert a renal vasodilator influence and contribute to maintain normal RBF...
  86. ncbi The renal arterial resistance index and renal allograft survival
    Jörg Radermacher
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    N Engl J Med 349:115-24. 2003
    ..We tested whether a renal arterial resistance index of less than 80 was predictive of long-term allograft survival...
  87. pmc Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow
    Vladimir Krejci
    Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, St Louis, MO 63110, USA
    Crit Care 11:R129. 2007
    ..The aim of this study was to measure the effects of low-dose vasopressin on regional (hepato-splanchnic and renal) and microcirculatory (liver, pancreas, and kidney) blood flow in septic shock...
  88. ncbi Norepinephrine and vital organ blood flow
    David Di Giantomasso
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
    Intensive Care Med 28:1804-9. 2002
    ..To test whether norepinephrine (NE) infusion at 0.4 microg kg(-1) min(-1) adversely affects regional blood flow in the normal mammalian circulation...
  89. ncbi Systemic and renal macro- and microcirculatory responses to arginine vasopressin in endotoxic rabbits
    Martin Albert
    Critical Care Division, Royal Victoria Hospital, Victoria, BC, Canada
    Crit Care Med 32:1891-8. 2004
    ..To investigate this further, we studied the effect of arginine vasopressin on systemic and renal blood flow in anesthetized, ventilated rabbits given either intravenous saline or endotoxin, and the impact of blocking V1a receptors...
  90. ncbi Assessment of renal functional phenotype in mice lacking gp91PHOX subunit of NAD(P)H oxidase
    Mohammed Z Haque
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Hypertension 43:335-40. 2004
    ..These results also suggest that the mechanism of Ang II-mediated renal vascular action involves concomitant generation of O2-...
  91. ncbi Suprarenal fixation: effect on blood flow of an endoluminal stent wire across an arterial orifice
    Kurt Liffman
    Energy and Thermofluids Engineering, CSIRO MIT, Highett, Victoria, Australia
    J Endovasc Ther 10:260-74. 2003
    ..To investigate what effect, if any, the presence of a stent wire in front of a renal artery has on the volume flow rate of blood through the renal artery...
  92. ncbi Renal Doppler resistance indices are associated with systemic atherosclerosis in kidney transplant recipients
    Gunnar H Heine
    Medical Department IV, Nephrology, University Homburg, Homburg, Germany
    Kidney Int 68:878-85. 2005
    ..We hypothesized that resistance indices are associated with cardiovascular risk factors and with subclinical systemic atherosclerosis in transplant recipients...
  93. ncbi Inhibition of nitric oxide synthase enhances superoxide activity in canine kidney
    Dewan S A Majid
    Dept of Physiology, SL 39, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Regul Integr Comp Physiol 287:R27-32. 2004
    ..These data suggest that NO synthase inhibition causes enhancement of endogenous O(2)(-) levels and support the hypothesis that NO plays a protective role against the actions of O(2)(-) in the kidney...
  94. ncbi Vasopressin vs norepinephrine in endotoxic shock: systemic, renal, and splanchnic hemodynamic and oxygen transport effects
    Jorge A Guzman
    Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol (1985) 95:803-9. 2003
    ..Our data demonstrate that, in contrast to NE, administration of AVP effectively restores renal blood flow and Do2 with comparable systemic and splanchnic hemodynamic and metabolic effects in endotoxin-induced circulatory shock...
  95. ncbi Mechanisms underlying the differential control of blood flow in the renal medulla and cortex
    Roger G Evans
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    J Hypertens 22:1439-51. 2004
    ....
  96. ncbi Magnesium supplementation combined with N-acetylcysteine protects against postischemic acute renal failure
    Magali de Araujo
    Department of Nephrology, Laboratory of Basic Research, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Am Soc Nephrol 16:3339-49. 2005
    ..In ischemic/reperfusion injury, renal function benefits more from the magnesium-NAC combination than from magnesium alone...
  97. ncbi Correlation between the resistive index by Doppler ultrasound and kidney function and histology
    Ryota Ikee
    Department of Nephrology, Kidney and Dialysis Center, Shonan Kamakura General Hospital, Kanagawa, Saitama, Japan
    Am J Kidney Dis 46:603-9. 2005
    ..Although duplex Doppler ultrasonography has been used widely, it still is unknown whether resistive index could be related directly to vascular or tubulointerstitial changes in the kidney...
  98. ncbi Renal effects of nitric oxide in endotoxemia
    R I Cohen
    Division of Pulmonary and Critical Care Medicine, The Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    Am J Respir Crit Care Med 164:1890-5. 2001
    ..We conclude that NO in endotoxemia is beneficial because it maintains RBF and GFR. Additionally, selective NOS inhibition did not offer any advantages over saline resuscitation...
  99. ncbi L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats
    Matthieu Legrand
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Physiol Renal Physiol 296:F1109-17. 2009
    ..L-NIL can prevent ischemic-induced renal microvascular hypoxia...
  100. ncbi Rho kinase regulates renal blood flow by modulating eNOS activity in ischemia-reperfusion of the rat kidney
    Amanda M G Versteilen
    Laboratory for Physiology, Faculty of Medicine, VU University Medical Center, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Renal Physiol 291:F606-11. 2006
    ..These findings indicate that in vivo inhibition of Rho kinase in renal I/R preserves renal blood flow by improving eNOS function...
  101. ncbi Differences in cortical microcirculation in the kidneys of unilaterally congenital hydronephrotic rats
    M Heuser
    Department of Urology, Georg-August-University, , D-37075, Germany
    Microvasc Res 62:172-8. 2001
    ..The hydronephrotic kidney shows significant microcirculatory differences compared to normal kidneys that should be taken into account when using a hydronephrotic model for pharmacological testing...

Research Grants62

  1. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
    ..R21 funding mechanism because it is exploratory, testing a novel mechanistic model of relaxin action in the renal circulation, proposes a new methodological approach to testing this mechanistic model in vivo that is in need of ..
  2. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
    ..We will instead use the rabbit renal circulation since it presents an arterial bifurcation (aorta to renal) of similar dimensions as the MCA...
  3. KIDNEY DISEASE RESEARCH TRAINING PROGRAM
    John C Lieske; Fiscal Year: 2012
    ..3 from the Department of Urology, and 22 from other divisions or departments organized in 9 research units (renal circulation and hypertension;mechanisms of acute and chronic renal injury;diabetes and nutrition;mineral and electrolyte ..
  4. RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    Holly Middlekauff; Fiscal Year: 2000
    ..the mechanisms underlying this exercise intolerance are multifactorial, abnormal reflex control of the renal circulation is likely an important component...
  5. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 1999
    ..In spite of the vast literature discussing renal circulation, the mechanisms underlying renal vascular disorders in various forms of hypertension are poorly understood...
  6. REGULATION OF RENAL CIRCULATION
    DONALD MARSH; Fiscal Year: 1990
    ....
  7. Non-linear regulation of the renal circulation
    DONALD MARSH; Fiscal Year: 2007
    ..The revised proposal answers questions raised in the first review, and presents new results from simulations of coupled cortical and medullary nephrons. ..
  8. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  9. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  10. Reactive Oxygen Species American Society of Nephrology Fall 2007
    THOMAS PALLONE; Fiscal Year: 2007
    ..Attendance of young scientists insures that the information will be translated into future studies that elucidate the role of ROS in kidney diseases and treatment thereof. [unreadable] [unreadable] [unreadable]..
  11. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  12. Calcium Signaling in Vasa Recta Endothelium
    THOMAS PALLONE; Fiscal Year: 2004
    ..We will test whether DVR contractions to norepinephrine, Angll and KCI are increased, measure NO production and assess effects of OH on endothelial and pericyte Ca2+ signaling. ..
  13. VASOMOTOR CONTROL OF DESCENDING VASA RECTA
    THOMAS PALLONE; Fiscal Year: 2003
    ....
  14. MECHANISMS OF RENAL IMPAIRMENT IN HYPERCHOLESTEROLEMIA
    Lilach Lerman; Fiscal Year: 2003
    ..Aim # 4 is to characterize intrarenal morphology in the HC pig model using 3-d x-ray micro-CT of microfil vascular casts and conventional light microscopy histology of tissue sections. ..
  15. MICROVASCULAR TRANSPORT IN THE RENAL MEDULLA
    THOMAS PALLONE; Fiscal Year: 2002
    ..Exchange of albumin and middle molecular weight solutes will also be simulated. ..
  16. 20-HETE IN NO-MEDIATED REGULATION OF RENAL FUNCTION
    Adebayo Oyekan; Fiscal Year: 2001
    ....
  17. Center for Advanced Renal Microscopic Analysis
    Bruce Molitoris; Fiscal Year: 2006
    ..The research development and support activities of the imaging facility are expected to provide numerous opportunities to impact the understanding of renal disease processes and therapeutic interventions. ..
  18. Non-Invasive Optical Determination of GFR
    Bruce Molitoris; Fiscal Year: 2008
    ..This has limited the ability to effectively test potential new therapies. PharmacoPhotonics, LLC is developing a non-invasive optical technique to meet this need. [unreadable] [unreadable] [unreadable]..
  19. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 2001
    ....
  20. RAB5 AND PI-3-KINASE AND GENTAMICIN TOXICITY
    Bruce Molitoris; Fiscal Year: 2002
    ..By performing these studies, it is hoped that formulation of specific therapies to delay and/or inhibit this toxicity will become possible. ..
  21. Ischemia-induced Actin Cytoskeletal Alterations
    Bruce Molitoris; Fiscal Year: 2008
    ..abstract_text> ..
  22. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  23. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  24. MECHANISMS OF RISK TO DIABETIC NEPHROPATHY IN BLACKS
    Deborah Price; Fiscal Year: 2003
    ..Our goal in this study is to explore preliminary evidence that RAS activation and the combination with other polymorphic genes accounts for many Type II DM features involving renal risk and racial differences in risk. ..
  25. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  26. Renin regulation by nitric oxide
    WILLIAM BEIERWALTES; Fiscal Year: 2007
    ..These studies should reveal the dual pathways by which NO can either inhibit or stimulate renin secretion. ..
  27. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  28. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  29. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. Gender and susceptibility to kidney damage in high BP
    Jane F Reckelhoff; Fiscal Year: 2010
    ....
  31. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..
  32. Prostaglandins: Kinins and Angiotensin Interactions
    JOHN MC GIFF; Fiscal Year: 2009
    ..3) Heme oxygenase activity and suppression of EET and 20-HETE synthesis. 4) Activation of peroxisome-proliferator-activated receptor alpha by Fibrates with stimulation of EET synthesis. ..
  33. Can Studies of Co-Morbidities with TMJDs Reveal Common Mechanisms of Disease?
    Allen Cowley; Fiscal Year: 2008
    ..A major goal of this meeting is to identify common therapeutic targets related to shared co-morbidities. [unreadable] [unreadable] [unreadable]..
  34. Mechanisms of Hypertension-induced Renal Injury
    Allen W Cowley; Fiscal Year: 2010
    ..An understanding of these mechanisms could lead to new therapeutic approaches for the prevention of kidney disease in hypertension. ..
  35. SUSCEPTIBILITY TO HYPERTENSIVE TARGET ORGAN DAMAGE
    Anil Bidani; Fiscal Year: 2003
    ....
  36. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  37. RENAL INTERSTITIAL HYDROSTATIC PRESSURE IN PREGNANCY
    ALI KHRAIBI; Fiscal Year: 2003
    ....
  38. Advancing Diagnostic Approaches for TMJ Disorders
    Allen Cowley; Fiscal Year: 2004
    ..abstract_text> ..
  39. Folic Acid Intake and Risk of Hypertension
    John Forman; Fiscal Year: 2004
    ..Subsequently, the risk of hypertension will be analyzed in > 2000 men and women genotyped for eNOS, and > 7000 men and women genotyped for MTHFR. Interaction with folate will be analyzed. ..
  40. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2001
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  41. Role of Myosin II in Ischemic Acute Renal Failure
    Timothy Sutton; Fiscal Year: 2006
    ..Mutant forms of MLCK and ROCK proteins will be co-expressed in MDCK cells to alter cellular signaling. ..
  42. Joint and Muscle Dysfunction of Temporomandibular Joint
    Allen Cowley; Fiscal Year: 2002
    ....
  43. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 2001
    ....
  44. eNOS: Metabolism & Vascular Biology in Health & Disease
    M Laughlin; Fiscal Year: 2007
    ..The strong group of investigators submitting this application is uniquely qualified and prepared to accomplish these goals. ..
  45. A Systems Approach to the Understanding of TMJ as a Complex Disease
    Allen Cowley; Fiscal Year: 2006
    ..abstract_text> ..
  46. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..whether increased SOD1 in transgenic mice protects against hypertension similar to tempol; d. the role of NADPH oxidase, by measuring p22 phox expression and the effect of apocynin. ..
  47. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  48. PATHOGENIC MECHANISMS AND INTERVENTION STRATEGIES IN HUS
    Richard Siegler; Fiscal Year: 2002
    ....
  49. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2002
    ....
  50. MODULATION OF T LYMPHOCYTE REGULATION
    Christian LeGuern; Fiscal Year: 2009
    ..abstract_text> ..
  51. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2008
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  52. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  53. Nephron Count, Birth Weight & Hypertensive Renal Disease
    Michael Hughson; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Regulation of Sodium Excretion in Knockout Mice
    John Lorenz; Fiscal Year: 2008
    ..abstract_text> ..
  55. NEURAL CIRCUITRY OF THE KIDNEY
    Mark Weiss; Fiscal Year: 2006
    ..abstract_text> ..
  56. Pyrophosphate in vascular calcification of renal failure
    W CHARLES O apos NEILL; Fiscal Year: 2010
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..