regional blood flow

Summary

Summary: The flow of BLOOD through or around an organ or region of the body.

Top Publications

  1. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
  2. pmc Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Neurol Neurosurg Psychiatry 80:392-9. 2009
  3. ncbi A general kinetic model for quantitative perfusion imaging with arterial spin labeling
    R B Buxton
    Department of Radiology, University of San Diego, California, USA
    Magn Reson Med 40:383-96. 1998
  4. ncbi Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements
    Matthias Gunther
    Advanced MRI Technologies, Sebastopol, California 95472, USA
    Magn Reson Med 54:491-8. 2005
  5. pmc Differences in endothelial function between Korean-Asians and Caucasians
    Jongeun Yim
    Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92350, USA
    Med Sci Monit 18:CR337-43. 2012
  6. ncbi The contribution of skin blood flow in warming the skin after the application of local heat; the duality of the Pennes heat equation
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, CA 92350, USA
    Med Eng Phys 33:325-9. 2011
  7. ncbi Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis
    Mona Pache
    University Eye Clinic Basel, University Hospital Basel, Basel, Switzerland
    Eur Neurol 49:164-8. 2003
  8. ncbi Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults
    D S Celermajer
    Cardiothoracic Unit, Hospital for Sick Children, London
    Circulation 88:2149-55. 1993
  9. ncbi Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?
    Daniel R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heiderberglaan 100, 3584 CX Utrecht, The Netherlands
    J Am Coll Cardiol 45:1987-93. 2005
  10. ncbi The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma
    Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Exp Eye Res 93:141-55. 2011

Detail Information

Publications339 found, 100 shown here

  1. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
    ..This review discusses the potential role of OBF in glaucoma and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP...
  2. pmc Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Neurol Neurosurg Psychiatry 80:392-9. 2009
    ..The extracranial venous outflow routes in clinically defined multiple sclerosis (CDMS) have not previously been investigated...
  3. ncbi A general kinetic model for quantitative perfusion imaging with arterial spin labeling
    R B Buxton
    Department of Radiology, University of San Diego, California, USA
    Magn Reson Med 40:383-96. 1998
    ..In preliminary experiments with a human subject, the model provided a good description of pulsed ASL data during a simple sensorimotor activation task...
  4. ncbi Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements
    Matthias Gunther
    Advanced MRI Technologies, Sebastopol, California 95472, USA
    Magn Reson Med 54:491-8. 2005
    ..For arterial spin labeling, single-shot 3D imaging techniques are optimal in terms of efficiency and might prove beneficial to improve reliability of perfusion quantitation in a clinical setup...
  5. pmc Differences in endothelial function between Korean-Asians and Caucasians
    Jongeun Yim
    Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92350, USA
    Med Sci Monit 18:CR337-43. 2012
    ..The aim of this study was to see if there were any differences in endothelial function between Koreans and Caucasians...
  6. ncbi The contribution of skin blood flow in warming the skin after the application of local heat; the duality of the Pennes heat equation
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, CA 92350, USA
    Med Eng Phys 33:325-9. 2011
    ....
  7. ncbi Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis
    Mona Pache
    University Eye Clinic Basel, University Hospital Basel, Basel, Switzerland
    Eur Neurol 49:164-8. 2003
    ..0 +/- 0.4 pg/ml, range 1.1-2.8 vs. 1.5 +/- 0.2 pg/ml, range 0.9-2.0; p < 0.001). Moreover, the patients exhibited significant alterations of extraocular blood flow. The role of ET-1 in the inflammatory process remains to be clarified...
  8. ncbi Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults
    D S Celermajer
    Cardiothoracic Unit, Hospital for Sick Children, London
    Circulation 88:2149-55. 1993
    ..Endothelial dysfunction is an early event in atherogenesis, and we hypothesized that smoking might be associated with endothelial damage in the systemic arteries of otherwise healthy young adults...
  9. ncbi Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?
    Daniel R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heiderberglaan 100, 3584 CX Utrecht, The Netherlands
    J Am Coll Cardiol 45:1987-93. 2005
    ..The aim of this research was to study whether the relation between endothelial function measured by flow-mediated dilation (FMD) of the brachial artery and cardiovascular risk factors is affected by the baseline cardiovascular risk...
  10. ncbi The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma
    Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Exp Eye Res 93:141-55. 2011
    ..Indeed there is data indicating that reduction of IOP by pharmacological intervention improves optic nerve head blood flow regulation independently of an ocular vasodilator effect...
  11. ncbi A device to measure heat flow through the skin in people with diabetes
    Jerrold Scott Petrofsky
    Department of Physical Therapy, Loma Linda University, California 92350, USA
    Diabetes Technol Ther 12:737-43. 2010
    ..To understand the heat transfer properties of the skin in different parts of the body and how it is altered by skin blood flow, age, and glycemic control, a new device was developed...
  12. pmc Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
    M T Gladwin
    Critical Care Medicine Department of the Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:11482-7. 2000
    ....
  13. ncbi Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation
    Ann E Donald
    Vascular Physiology Unit, UCL Institute of Child Health, London, United Kingdom
    J Am Coll Cardiol 51:1959-64. 2008
    ..Our aim was to determine reproducibility of the flow-mediated dilation (FMD) response profile, and discriminatory ability of the components...
  14. ncbi Performance of near-infrared spectroscopy in measuring local O(2) consumption and blood flow in skeletal muscle
    M C van Beekvelt
    Department of Physiology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
    J Appl Physiol (1985) 90:511-9. 2001
    ....
  15. ncbi Use of the retinal vessel analyzer in ocular blood flow research
    Gerhard Garhofer
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Acta Ophthalmol 88:717-22. 2010
    ..Unresolved questions and the possible limitations of the technique are also discussed...
  16. pmc Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Cardiovasc Magn Reson 13:66. 2011
    ..Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO2 in the femoral circulation as part of a single procedure...
  17. ncbi Ocular blood flow assessment using continuous laser Doppler flowmetry
    Charles E Riva
    Department of Ophthalmology Dir Prof Emilio Campos, University of Bologna, Italy
    Acta Ophthalmol 88:622-9. 2010
    ..Various problems still need to be solved in order to bring to light the full potential of LDF in the assessment of microcirculatory haemodynamics...
  18. pmc Evaluation of 3D blood flow patterns and wall shear stress in the normal and dilated thoracic aorta using flow-sensitive 4D CMR
    Jonas Bürk
    Department of Diagnostic Radiology, Medical Physics, University Hospital, Freiburg, Germany
    J Cardiovasc Magn Reson 14:84. 2012
    ..The purpose of this study was to investigate 3D flow patterns and vessel wall parameters in patients with dilated ascending aorta, age-matched subjects, and healthy volunteers...
  19. ncbi Comparison of choroidal and optic nerve head blood flow regulation during changes in ocular perfusion pressure
    Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 53:4337-46. 2012
    ....
  20. ncbi Choroidal blood flow and progression of age-related macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization
    Agnes Boltz
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 51:4220-5. 2010
    ..On the basis of these results, the hypothesis for this study was that lower choroidal blood flow is associated with an increased risk of CNV in patients with AMD...
  21. ncbi Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging
    Duygu Tosun
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 52:186-97. 2010
    ..Compared to reduced rCBF, regional cortical thinning better explained the variability in dementia severity. In conclusion, structural brain alterations compared to physiological variations are the dominant features of MRI in AD...
  22. pmc Reduced endothelial function in the skin in Southeast Asians compared to Caucasians
    Jerrold Sott Petrofsky
    Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92350, USA
    Med Sci Monit 18:CR1-8. 2012
    ..The reaction of vascular endothelial cells to occlusion and heat in Southeast Asian Indians (SAI) compared to Caucasians (C) has not been studied, although genetic differences are found in endothelial cells between the races...
  23. ncbi Assessment of cerebral venous return by a novel plethysmography method
    Paolo Zamboni
    Vascular Diseases Centre, University of Ferrara, Ferrara, Italy
    J Vasc Surg 56:677-85.e1. 2012
    ..The purpose of this study was to assess the cerebral venous return in relation to the change in position by means of a novel cervical plethysmography method...
  24. pmc Cerebral white matter blood flow and arterial blood pressure in preterm infants
    Klaus Børch
    Department of Neonatology, Rigshospitalet and University of Copenhagen, Denmark
    Acta Paediatr 99:1489-92. 2010
    ..It is generally assumed that one reason why white matter injury is common in preterm infants is the relatively poor vascular supply...
  25. ncbi Comparative velocity investigations in cerebral arteries and aneurysms: 3D phase-contrast MR angiography, laser Doppler velocimetry and computational fluid dynamics
    Dorothea I Hollnagel
    Institute of Neuroradiology, University Hospital Zurich, Zurich, Switzerland
    NMR Biomed 22:795-808. 2009
    ....
  26. ncbi Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure
    Gert Reiter
    Siemens Medical Solutions, Graz, Austria
    Circ Cardiovasc Imaging 1:23-30. 2008
    ..Such pathological altered pressures in the pulmonary vascular system should lead to changes in blood flow patterns in the main pulmonary artery...
  27. ncbi The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics
    P Zamboni
    Vascular Diseases Center, University of Ferrera, and Bellaria Neurosciences, Ferrara and Bologna, Italy
    Funct Neurol 24:133-8. 2009
    ..027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). This study demonstrates that venous outflow disturbances in the form of CCSVI significantly impact on CSF pathophysiology in patients with MS...
  28. ncbi Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    F N Witherow
    Department of Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, UK
    Circulation 104:2177-81. 2001
    ....
  29. ncbi Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131 University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur Heart J 26:363-8. 2005
    ..However, the absolute values obtained using this approach vary considerably across studies. We studied whether technical aspects of the methodology can explain the wide variety in absolute values across studies...
  30. ncbi CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke
    James D Eastwood
    Depts of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710 3808, USA
    Radiology 222:227-36. 2002
    ..To measure mean cerebral blood flow (CBF) in ischemic and nonischemic territories and in low-attenuation regions in patients with acute stroke by using deconvolution-derived hemodynamic imaging...
  31. ncbi Role of NO in choroidal blood flow regulation during isometric exercise in healthy humans
    Alexandra Luksch
    Department of Clinical Pharmacology, University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 44:734-9. 2003
    ..The hypothesis for the study was that inhibition of NOS may influence choroidal blood flow during isometric exercise...
  32. ncbi High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm
    Johannes Pleiner
    Department of Clinical Pharmacology, University of Vienna, Austria
    Circulation 106:1460-4. 2002
    ..Acute inflammation causes endothelial vasodilator dysfunction that may be mediated by oxidative stress...
  33. pmc The ability of the skin to absorb heat; the effect of repeated exposure and age
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, CA 92350, USA
    Med Sci Monit 17:CR1-8. 2011
    ..While heat flow has been studied after applying a single heat exposure, the physiology of repeated exposures to local heat has not been well investigated...
  34. ncbi A primer on functional magnetic resonance imaging
    Gregory G Brown
    Psychology Service MC 116B, VA San Diego Healthcare System, 3350 La Jolla Village Drive, La Jolla, California 92161, USA
    Neuropsychol Rev 17:107-25. 2007
    ..In the fourth section, calibrated fMRI, which uses BOLD and ASL to infer alterations of oxygen utilization during behavioral activation, is reviewed. The discussion concludes with challenges confronting studies of individual cases...
  35. ncbi Autoregulation, a balancing act between supply and demand
    Josef Flammer
    University Eye Clinic Basel, Mittlere Str 91, Basel, Switzerland
    Can J Ophthalmol 43:317-21. 2008
    ..This instability, in turn, induces a repeated mild reperfusion injury. The resulting oxidative stress contributes to the pathogenesis of glaucomatous optic neuropathy...
  36. ncbi Altered nitric oxide system in patients with open-angle glaucoma
    Kaija Polak
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Arch Ophthalmol 125:494-8. 2007
    ..To investigate the ocular blood flow response to systemic nitric oxide synthase inhibition in patients with primary open-angle glaucoma...
  37. ncbi A fluorescein and indocyanine green angiographic study of choriocapillaris in age-related macular disease
    D Pauleikhoff
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Arch Ophthalmol 117:1353-8. 1999
    ..To examine the phenomenon of a prolonged choroidal filling phase (PCFP) as seen on fluorescein and indocyanine green (ICG) angiography in patients with early age-related macular disease (AMD)...
  38. pmc Impact of age, sex, and exercise on brachial artery flow-mediated dilatation
    Mark A Black
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 2ET, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H1109-16. 2009
    ..In OS men, who had relatively preserved NO dilator function, no training adaptations were observed. This study has potential implications for the prevention of conduit artery endothelial dysfunction in men and women...
  39. pmc Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans
    William G Schrage
    Department of Kinesiology, 1149A Natatorium, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 579:227-36. 2007
    ..Lower exercise hyperaemia in older humans may be mediated in part by less NO- and PG-mediated vasodilatation during exercise...
  40. ncbi Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice
    Jörn Tongers
    Department of Cardiology and Angiology, Hannover University Medical School, 30625 Hannover, Germany
    Cardiovasc Res 78:294-300. 2008
    ..We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI)...
  41. ncbi Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation
    Brett J Wong
    Department of Exercise and Movement Science, University of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol 95:504-10. 2003
    ..9126 +/- 1088% CVC(max. s) after a 15-min arterial occlusion. These data suggest that NO does not directly mediate reactive hyperemia and that NO is not produced in response to an increase in shear stress in the cutaneous circulation...
  42. ncbi Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular function
    Tommaso Gori
    Department of Internal, Cardiovascular and Geriatric Medicine, University of Siena, Siena, Italy
    J Am Coll Cardiol 51:1953-8. 2008
    ..We describe and validate a novel noninvasive method that complements the data from "traditional" flow-mediated dilation (FMD) studies...
  43. pmc Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects
    F A Dinenno
    Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Physiol 531:573-9. 2001
    ....
  44. ncbi Nitric oxide and neurally mediated regulation of skin blood flow during local heating
    C T Minson
    Department of Exercise and Movement Science, University of Oregon, 1240 Univ of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol (1985) 91:1619-26. 2001
    ....
  45. ncbi Principles, techniques, and limitations of near infrared spectroscopy
    Marco Ferrari
    Department of Biomedical Sciences and Technologies, University of L Aquila, Italy
    Can J Appl Physiol 29:463-87. 2004
    ..The possibility of measuring the cortical activation in response to different stimuli, and the changes in the cortical cytochrome oxidase redox state upon O2 delivery changes, will also be mentioned...
  46. ncbi Color Doppler imaging in ocular hypertension and open-angle glaucoma
    Cengiz Akarsu
    Department of Ophthalmology, University of Kirikkale, Kirikkale, 71100, Turkey
    Graefes Arch Clin Exp Ophthalmol 242:125-9. 2004
    ..To quantify the retrobulbar hemodynamics of patients with ocular hypertension and open-angle glaucoma and to compare it with that of normal subjects...
  47. ncbi Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 106:1349-54. 2002
    ..We tested the hypothesis that this is due to a reduction in postjunctional alpha-adrenergic responsiveness to endogenous norepinephrine (NE) release and determined whether this was specific to alpha1- or alpha2-adrenergic receptors...
  48. ncbi Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure
    Elzbieta Polska
    Department of Clinical Pharmacology, Division of Ophthalmo Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 48:3768-74. 2007
    ..To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP)...
  49. ncbi Transient limb ischemia induces remote ischemic preconditioning in vivo
    R K Kharbanda
    University College, London, UK
    Circulation 106:2881-3. 2002
    ..We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size...
  50. ncbi Association between duplex Doppler sonographic flow pattern in right hepatic vein and various liver diseases
    A von Herbay
    Department of Gastroenterology, Hepatology and Infectious Diseases, , Moorenstrasse 5, , Germany
    J Clin Ultrasound 29:25-30. 2001
    ..CONCLUSIONS: Type 3 waveforms in the right hepatic vein are suggestive of liver cirrhosis, although they may also occur in patients with fibrosis, fatty liver disease, or metastatic liver disease...
  51. ncbi Reduced foveolar choroidal blood flow in eyes with increasing AMD severity
    Juan E Grunwald
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 46:1033-8. 2005
    ..To explore further the choroidal circulatory changes in patients with AMD, the relationship between ChBFlow and fundus features associated with increased risk of choroidal neovascularization (CNV) were investigated...
  52. ncbi Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique
    A Stefanovska
    Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    IEEE Trans Biomed Eng 46:1230-9. 1999
    ..01 Hz. The study illustrates the potential of laser Doppler flowmetry combined with dynamical systems analysis for studies of both the micro- and macroscopic mechanisms of blood flow regulation in vivo...
  53. ncbi p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling
    Yves Castier
    INSERM Centre de Recherche Cardiovasculaire Lariboisiere, Paris, France
    Circ Res 97:533-40. 2005
    ..Generated ROS interact with NO to produce peroxynitrite, which in turn activates MMPs, facilitating vessel remodeling. Our study provides the first evidence that ROS play a fundamental role in flow-induced vascular enlargement...
  54. ncbi Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium
    Michelle A Vincent
    Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, 10 Center Drive, Building 10, Room 6C 205, Bethesda, MD 20892 1632, USA
    Curr Diab Rep 3:279-88. 2003
    ..Taken together, these observations suggest a molecular mechanism that may help to explain how insulin resistance contributes to cardiovascular components of the metabolic syndrome and vascular complications of diabetes...
  55. ncbi Sublingual capnometry tracks microcirculatory changes in septic patients
    Jacques Creteur
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 32:516-23. 2006
    ..To test the hypothesis that microcirculatory blood flow is the main determinant of sublingual carbon dioxide pressure in patients with septic shock...
  56. ncbi Development-related changes in the expression of shear stress responsive genes KLF-2, ET-1, and NOS-3 in the developing cardiovascular system of chicken embryos
    Bianca C W Groenendijk
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 230:57-68. 2004
    ..Our results suggest that, in the embryonic cardiovascular system, KLF-2 is expressed in regions of highest shear stress, and that ET-1 and NOS-3 expression, at least in the later stages, is related to shear stress...
  57. ncbi Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activity
    Julie B Schweitzer
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 56:597-606. 2004
    ..We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD)...
  58. ncbi Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation
    Michel L Hijmering
    Department of Internal Medicine, Eemland Hospital, Amersfoort, The Netherlands
    J Am Coll Cardiol 39:683-8. 2002
    ..We sought to evaluate whether increased sympathetic outflow may interfere with flow-mediated dilation (FMD)...
  59. ncbi Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
    T W Secomb
    Department of Physiology, University of Arizona, Tucson, USA
    Acta Oncol 34:313-6. 1995
    ..These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia...
  60. ncbi Duplex ultrasound for assessment of superior mesenteric artery blood flow
    M J Perko
    Department of Vascular Surgery and Cardiothoracic Surgery, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Eur J Vasc Endovasc Surg 21:106-17. 2001
    ....
  61. ncbi Role of nitric oxide in the vascular effects of local warming of the skin in humans
    D L Kellogg
    Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, 78284, USA
    J Appl Physiol (1985) 86:1185-90. 1999
    ..Thus NOS inhibition attenuated, and sodium nitroprusside restored, the cutaneous vasodilation induced by elevation of Tloc; therefore, the mechanism of cutaneous vasodilation by local warming requires NOS generation of NO...
  62. ncbi Mechanism of venous valve closure and role of the valve in circulation: a new concept
    Fedor Lurie
    Straub Foundation, Honolulu, HI 96814, USA
    J Vasc Surg 38:955-61. 2003
    ....
  63. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  64. ncbi ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat
    Saema A S Beg
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 26:846-56. 2006
    ..The results suggest that ERK1/2 inhibition might be a potential treatment for the prevention of cerebral vasospasm and ischemia associated with SAH...
  65. ncbi Involvement of glial cells in the autoregulation of optic nerve head blood flow in rabbits
    Maho Shibata
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 53:3726-32. 2012
    ..To investigate the involvement of glial cells in the autoregulation of optic nerve head (ONH) blood flow in response to elevated intraocular pressure (IOP)...
  66. ncbi Temporal and spatial variations of cell-free layer width in arterioles
    Sangho Kim
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 293:H1526-35. 2007
    ..The temporal variations increase as diameter increases and are inversely related on opposite sides of the vessel...
  67. ncbi Regional blood flow after pneumatic anti-shock garment inflation
    Mark Hauswald
    Department of Clinical Affairs, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 5121, USA
    Prehosp Emerg Care 7:225-8. 2003
    ..To determine whether fully inflated pneumatic anti-shock garments (PASGs) decrease blood flow to abdominal and retroperitoneal organs...
  68. ncbi The relationship between shear rate and flow-mediated dilation is altered by acute exercise
    T L Llewellyn
    School of Health, Physical Education, and Recreation, University of Nebraska at Omaha, Omaha, NE 68198 5850, USA
    Acta Physiol (Oxf) 205:394-402. 2012
    ..The aims of this study were to compare brachial artery endothelial function at rest and post-exercise in and to compare the data expressed as a percent change and normalized to shear rate (SR)...
  69. ncbi The association of ocular blood flow with haemorheological parameters in primary open-angle and exfoliative glaucoma
    Mehmet Ali Sekeroğlu
    Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey
    Acta Ophthalmol 89:429-34. 2011
    ....
  70. ncbi Viscoelastic relaxation and regional blood flow response to spinal cord compression and decompression
    G D Carlson
    University Hospitals Spine Institute, Department of Orthopaedic Surgery, Cleveland, Ohio, USA
    Spine (Phila Pa 1976) 22:1285-91. 1997
    ..primary mechanical factors of spinal cord trauma and secondary mechanisms of injury, this study evaluated regional blood flow and somatosensory evoked potential function in an in vivo canine model with controlled velocity spinal cord ..
  71. ncbi Effect of aortic taper on patterns of blood flow and wall shear stress in rabbits: association with age
    Véronique Peiffer
    Department of Aeronautics, Imperial College London, South Kensington Campus, United Kingdom
    Atherosclerosis 223:114-21. 2012
    ..The distribution of atherosclerotic lesions changes with age in human and rabbit aortas. We investigated if this can be explained by changes in patterns of blood flow and wall shear stress...
  72. ncbi Systemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats
    M M Sholook
    Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Heart Circ Physiol 293:H2080-4. 2007
    ..Mean arterial pressure (MAP), CO, cardiac index (CI), TPR, and regional blood flow to various tissues were measured using radiolabeled microspheres in the following two groups of conscious ..
  73. ncbi Sympathetic and haemodynamic responses to lipids in healthy human ageing
    John P Florian
    Intercollege Graduate Degree Program in Physiology and Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Exp Physiol 95:486-97. 2010
    ....
  74. ncbi The interrealtionship between locally applied heat, ageing and skin blood flow on heat transfer into and from the skin
    Jerrold Petrofsky
    Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, California, USA
    J Med Eng Technol 35:262-74. 2011
    ..Thus, a consequence of ageing is reduced excess BF in response to thermal stress increasing susceptibility to thermal damage. This must be considered in modelling of BF...
  75. ncbi Aortic regurgitation dramatically alters the distribution of atherosclerotic lesions and enhances atherogenesis in mice
    Yu Qing Zhou
    Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 30:1181-8. 2010
    ..We developed a mouse model of aortic valve regurgitation (AR) to change the aortic flow pattern and observed the effects on plaque formation...
  76. ncbi The range of adaptation by collateral vessels after femoral artery occlusion
    Inka Eitenmüller
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Circ Res 99:656-62. 2006
    ..Increased FSS activates the Ras-ERK-, the Rho-, and the NO- (but not the Akt-) pathway enabling collateral artery growth...
  77. ncbi Long-term measurement of cerebral blood flow and metabolism in a rat chronic hypoperfusion model
    Tatsuo Otori
    Internal Medicine II, Nippon Medical School, Tokyo, Japan
    Clin Exp Pharmacol Physiol 30:266-72. 2003
    ..6. These results showed that the BCAO in rats is an appropriate model for chronic cerebral hypoperfusion and that uncoupling of rCBF and rCGU was observed from 2 days until 4 weeks in the white matter...
  78. ncbi Laser Doppler perfusion monitoring and imaging: novel approaches
    Anne Humeau
    Groupe ISAIP ESAIP, 18 rue du 8 mai 1945, Saint Barthélemy d Anjou Cedex, France
    Med Biol Eng Comput 45:421-35. 2007
    ..Imaging perfusion is also reviewed through methods based on laser speckle. The most prominent disadvantage of the latter devices being the time needed to produce a perfusion image, solutions are proposed in the last part of the paper...
  79. ncbi Postprandial vascular reactivity in obese and normal weight young adults
    Julian G Ayer
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Obesity (Silver Spring) 18:945-51. 2010
    ..An exaggerated alteration in postprandial vascular reactivity is thus unlikely to contribute importantly to the increased cardiovascular risk of obesity...
  80. ncbi Hemodynamic relationships among upper-abdominal aorta and femoral arteries: basis for measurement of arterial blood flow to abdominal-pelvic organs
    Takuya Osada
    Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, Japan
    Med Sci Monit 15:CR332-40. 2009
    ..The aim was to examine 1) basal hemodynamic parameters such as vessel diameter (VD), blood velocity (BV), and BF and their relationship to Ao and FAs and 2) how both BFAo and BFFAs influence the magnitude of BFAP...
  81. ncbi The influence of age and diabetes on the skin blood flow response to local pressure
    Jerrold S Petrofsky
    Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92350, USA
    Med Sci Monit 15:CR325-31. 2009
    ..In the present investigation, these studies were expanded to look at the response of the hand, back, and foot to applied pressure...
  82. pmc Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats
    Christopher G Ellis
    Dept of Medical Biophysics, Univ of Western Ontario, London, ON, N6A 5C1, Canada
    Am J Physiol Heart Circ Physiol 298:H1661-70. 2010
    ....
  83. ncbi Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction
    Tadashi Suga
    Graduate School of Program in Lifelong Learning Studies, Hokusho University, Ebetsu, Hokkaido, Japan
    J Appl Physiol (1985) 106:1119-24. 2009
    ..This new method of resistance training needs to be examined for optimization of the protocol to reach equivalence with high-intensity resistance training...
  84. ncbi Impact of hydrotherapy on skin blood flow: How much is due to moisture and how much is due to heat?
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, California 92350, USA
    Physiother Theory Pract 26:107-12. 2010
    ..7 +/- 11.4 flux if the moisture of the water was blocked. Thus, a substantial portion of the increase in skin blood flow associated with warm water therapy is probably associated with moisturizing of the skin rather than the heat itself...
  85. ncbi Methodological issues in the assessment of skin microvascular endothelial function in humans
    Jean Luc Cracowski
    Department of Human Physiology, University of Oregon, OR 97403 1240, USA
    Trends Pharmacol Sci 27:503-8. 2006
    ..However, they are valuable tools and can be used as surrogate endpoints in clinical trials in which the assessment of microvascular function in humans is required...
  86. ncbi Comparison of regional blood flow values measured by radioactive and fluorescent microspheres
    Eckart Thein
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 27, D 81366 Munich, Germany
    Eur Surg Res 34:215-23. 2002
    ..FM) have become an attractive alternative to radioactive microspheres (RM) for the measurement of regional blood flow (RBF)...
  87. ncbi Flow-sensitive four-dimensional magnetic resonance imaging: flow patterns in ascending aortic aneurysms
    Ernst Weigang
    Department of Cardiothoracic and Vascular Surgery, University Hospital Mainz, Mainz, Germany
    Eur J Cardiothorac Surg 34:11-6. 2008
    ....
  88. ncbi Left ventricular flow patterns in healthy subjects and patients with prosthetic mitral valves: an in vivo study using echocardiographic particle image velocimetry
    Reka Faludi
    Department of Cardiology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    J Thorac Cardiovasc Surg 139:1501-10. 2010
    ....
  89. pmc Impact of shear rate modulation on vascular function in humans
    Toni M Tinken
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, 15 21 Webster St, Liverpool L3 2ET, United Kingdom
    Hypertension 54:278-85. 2009
    ....
  90. pmc Modification of vascular function after handgrip exercise training in 73- to 90-yr-old men
    Devon A Dobrosielski
    Wake Forest University, Winston Salem, NC, USA
    Med Sci Sports Exerc 41:1429-35. 2009
    ..To examine the influence of a unilateral exercise training protocol on brachial artery reactivity (BAR) in 12 men (aged 81 +/- 5 yr)...
  91. pmc Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolism
    Justin D Anderson
    Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, VA 22908, USA
    J Am Coll Cardiol 54:628-35. 2009
    ..We aimed to investigate the pathophysiology of peripheral arterial disease (PAD) by examining magnetic resonance imaging (MRI) and spectroscopic (MRS) correlates of functional capacity...
  92. ncbi Determination of age-related increases in large artery stiffness by digital pulse contour analysis
    S C Millasseau
    Department of Clinical Pharmacology, St Thomas Hospital, Centre for Cardiovascular Biology and Medicine, King s College London, Lambeth Palace Road, London SE1 7EH, UK
    Clin Sci (Lond) 103:371-7. 2002
    ..Thus contour analysis of the DVP provides a simple, reproducible, non-invasive measure of large artery stiffness...
  93. ncbi Retrobulbar blood flow velocities in open angle glaucoma and their association with mean arterial blood pressure
    Gerhard Garhofer
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 51:6652-7. 2010
    ..In the present study, the authors hypothesized that patients with POAG show an abnormal association between retrobulbar blood flow velocities as assessed with CDI and blood pressure, indicative of vascular dysregulation...
  94. ncbi Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats
    Kuo Ho Yeh
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Crit Care Med 40:169-77. 2012
    ..We hypothesized that combined treatment with extracorporeal shock wave and bone marrow-derived endothelial progenitor cells might exert enhanced protection against critical limb ischemia in rats...
  95. ncbi Evaluation of cyclosporine A in a stroke model in the immature rat brain
    Pierre Louis Leger
    UMR CNRS 7102, Université P and M Curie Paris6, 75005 Paris, France
    Exp Neurol 230:58-66. 2011
    ..This article is part of a Special Issue entitled "Interaction between repair, disease, & inflammation."..
  96. ncbi Use of colour Doppler imaging in ocular blood flow research
    Ingeborg Stalmans
    Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
    Acta Ophthalmol 89:e609-30. 2011
    ..The intention of this review is to standardize methods in CDI assessment that are used widely, but not to exclude other approaches or additional tests that individual laboratories may choose or continue to use...
  97. ncbi The anabolic benefits of venous blood flow restriction training may be induced by muscle cell swelling
    J P Loenneke
    Department of Health and Exercise Science, The University of Oklahoma, Norman, OK 73019 0615, USA
    Med Hypotheses 78:151-4. 2012
    ..We hypothesize that cell swelling is important for muscle growth and strength adaptation but when coupled with higher metabolic accumulation, this adaptation is even greater...
  98. ncbi Adenosine receptor inhibition with theophylline attenuates the skin blood flow response to local heating in humans
    Sarah M Fieger
    Department of Kinesiology, Kansas State University, Manhattan, KS 66506, USA
    Exp Physiol 95:946-54. 2010
    ..These data further suggest that a portion of the NO response may be explained by adenosine receptor activation; however, a substantial portion of the NO response is independent of adenosine receptor activation...
  99. pmc Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise
    David M Gundermann
    The Univ of Texas Medical Branch, Dept of Nutrition and Metabolism, Division of Rehabilitation Sciences, 301 Univ Blvd, Galveston, TX 77555 1124, USA
    J Appl Physiol (1985) 112:1520-8. 2012
    ..Further research is necessary to elucidate the cellular mechanism(s) responsible for the increase in mTOR signaling, MPS, and hypertrophy following acute and chronic BFR exercise...
  100. ncbi Sympathetic, parasympathetic and enteric regulation of the gastrointestinal vasculature in rainbow trout (Oncorhynchus mykiss) under normal and postprandial conditions
    Henrik Seth
    Department of Zoology, University of Gothenburg, S 405 30 Gothenburg, Sweden
    J Exp Biol 213:3118-26. 2010
    ....
  101. pmc Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans
    Brett J Wong
    Department of Kinesiology, Kansas State University, Manhattan, KS 66506, USA
    J Physiol 588:4317-26. 2010
    ..These data further suggest a portion of the NO component of thermal hyperaemia may be due to activation of TRPV-1 channels...

Research Grants64

  1. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..whether mitochondrial ATP synthase, a potentially contributing factor to the observed reductions in basal regional blood flow in hibernating tissue, will be further reduced in response to chronic pioglitazone in the pig model...
  2. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..pressure (LBNP), while measuring cardiac output by inert gas rebreathing, regional blood volume, and regional blood flow using plethysmographic techniques focusing on splanchnic changes, and muscle sympathetic nerve activity by ..
  3. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..In this model we will evaluate whether surgical revascularization normalizes regional blood flow at rest and with increased work load (dobutamine stress) by measuring blood flow (microsphere analysis) and ..
  4. TRP channels in regulation of vascular tone
    David X Zhang; Fiscal Year: 2013
    ..Flow or shear- induced dilation is one of the most important regulators of vascular tone and regional blood flow. Therefore the findings of this proposal will importantly contribute to our understanding of how coronary ..
  5. PHOSPHORYLATION AND ENDOTHELIAL NITRIC OXIDE PRODUCTION
    William C Sessa; Fiscal Year: 2013
    ..to this hypothesis, we predict that modulating eNOS phosphorylation will delay atherosclerosis and preserve regional blood flow and angiogenesis. To test these hypotheses, we will: 1...
  6. Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in Obesity
    Jerry Ingrande; Fiscal Year: 2013
    ..increases the risk of atherosclerosis, coronary artery disease, and mortality, and accounts for changes in regional blood flow, adipose tissue distribution, and cardiac function...
  7. A Controlled Clinical Trial of Regadenoson in Sickle Cell Anemia
    Donna S Neuberg; Fiscal Year: 2013
    ..and contrast-enhanced ultrasonography, novel outcome measures to assess pulmonary interstitial edema and regional blood flow, respectively...
  8. Vasoprotection by Caloric Restriction Mimetics in Aging
    Anna Csiszar; Fiscal Year: 2012
    ..are proposed: 1) Assess whether CR and CR mimetics can delay/prevent the age-associated decline in cerebral regional blood flow, the reduction in capillary and arteriolar density and angiogenesis, and the decline in spatial learning ..
  9. Exercise, histamine receptors, and vascular function
    Steven A Romero; Fiscal Year: 2012
    ..g. asthma, allergies) may be established as an influential regulator of day-to-day regional blood flow. Last, data collected from this project will contribute to the understanding and development of exercise as ..
  10. CT Method Development for Quantifying Myocardial Microvascular Flow Distribution
    ERIK LEO RITMAN; Fiscal Year: 2013
    ..This "gold standard" will be used to calibrate estimates of sub-resolution regional blood flow distributions obtained by nested-region-of-interest (nROI) analysis of clinical MSCT images of myocardial ..
  11. Angiomyogenesis with HIF-1a responsive microRNAs
    RAFEEQ HABEEBAHMED; Fiscal Year: 2012
    ..The end-points of in vivo studies will include blood vessel density analysis, maturation index and improved regional blood flow in the ischemic heart and preservation of global cardiac function...
  12. Exercise, Histamine Receptors, &Vascular Health In Aging
    John R Halliwill; Fiscal Year: 2013
    ..g., asthma, allergies, anaphylaxis, and tumor growth), can play important roles in day-to-day regulation of regional blood flow related to exercise...
  13. Arterial Smooth Muscle Chloride Channels
    Jonathan H Jaggar; Fiscal Year: 2013
    ..Cerebral arteries are major resistance vessels critical for control of brain regional blood flow. Cerebral artery smooth muscle cell membrane potential controls intracellular calcium ([Ca2+]i) ..
  14. PREGNANCY & HORMONE EFFECTS ON KIDNEY & URINARY TRACT
    Linda Shortliffe; Fiscal Year: 1999
    ..were previously developed for this rat model we will assess renal and urinary tract morphology, global and regional blood flow, and renal functional changes for these conditions...
  15. Neural bases of empathy and prosody
    Argye E Hillis; Fiscal Year: 2013
    ..Patients will be studied longitudinally through 6 months, to determine the factors, such as improved regional blood flow, that contribute to recovery.
  16. Pediatric CFS in a Community-Based Sample
    Leonard A Jason; Fiscal Year: 2013
    ..function of abnormalities in cerebral blood flow as it relates to total cardiac output, total blood volume, regional blood flow, and blood volume distribution during the orthostatic stressor...
  17. Enhanced Intraarterial Delivery of Chemotherapeutic Drugs to the Brain
    Shailendra Joshi; Fiscal Year: 2012
    ..investigate the role of lipid solubility in enhancing drug delivery to the brain, particularly when the regional blood flow is transiently (30- 60s) reduced...
  18. HYPOTHALAMIC OPIATES IN OBESITY-ACCELERATED HYPERTENSION
    Robin Rockhold; Fiscal Year: 1991
    ..Changes in distribution of regional blood flow (radio-labelled microspheres) and plasma catecholamine levels will be measured...
  19. COMPLEMENT-DEPENDENT PROSTAGLANDIN SYNTHESIS IN SEPSIS
    Mitchell Fink; Fiscal Year: 1991
    ..Cardiac output will be measured by thermodilution; regional blood flow will be assessed using radioactive microspheres; plasma levels of metabolites of PGE2 and PGI2 will be ..
  20. Fractional flow reserve measurement based on coronary angiographic images
    SABEE Y MOLLOI; Fiscal Year: 2010
    ..this research plan is to develop a technique for quantification of fractional flow reserve by combining the regional blood flow and lumen volume measurement technique and its implementation in the cardiac catheterization laboratory...
  21. REGULATING CEREBROSPINAL FLUID FORMATION
    Barry Hoffer; Fiscal Year: 1992
    ..act by reducing blood flow to the choroid plexus, the 14C- iodoantipyrine technique will be used to measure regional blood flow both before and after drug administration...
  22. NITRIC OXIDE AND MEDIATING PRESSURE NATRIURESIS
    DEWAN MAJID; Fiscal Year: 2000
    ..Total renal blood flow will be measured by electromagnetic flowmetry and the regional blood flow in the kidney will be assessed by single fibre laser- doppler flowmetry...
  23. DETERMINANTS OF REGIONAL LUNG EXPANSION AND PERFUSION
    Eric Hoffman; Fiscal Year: 1993
    ..Recent data in heart and kidney show peak regional brightness following a bolus contrast injection to be an accurate index of regional blood flow.
  24. ERYTHROPOIETIC AND HEMODYNAMIC RESPONSE TO HYPOXEMIA
    John Widness; Fiscal Year: 1990
    ..which may influence fetal plasma and amniotic fluid levels of erythropoietin (Ep), erythropoiesis, and regional blood flow in chronically hypoxemic fetal sheep...
  25. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2001
    ..We will simultaneously compare the regional blood flow and the mean peripheral arterial pressure in order to verify regional selectivity...
  26. SUBENDOCARDIAL O2 SUPPLY AND DEMAND IN AORTIC STENOSIS
    Peter Scholz; Fiscal Year: 1992
    ..b>Regional blood flow limitations in the subendocardium have been documented for many disease processes, including cardiac ..
  27. IONIC BASIS OF ISCHEMIC CEREBRAL EDEMA
    Wise Young; Fiscal Year: 1992
    ..Albumen and IgG passage across the blood brain barrier, regional blood flow, blood pressure, and plasma ionic levels will be monitored...
  28. ALCOHOLIC EMBRYOPATHY & MATERNAL HYPERTENSION
    RUSSELL MANKES; Fiscal Year: 1992
    ..of maternal ethanol consumption and spontaneous hypertension on the placenta, and its relationship to regional blood flow and to uterine artery vascular reactivity. 3...
  29. GASTROINTESTINAL KALLIKREIN AND RENIN SYSTEMS
    Patrick Ward; Fiscal Year: 1990
    ..so-called "brain/gut" peptides remain at an early stage of investigation, but could include modulation of regional blood flow and organ function...
  30. PURINERGIC AXIS OF CARDIAC BLOOD VESSELS
    IAIN BUXTON; Fiscal Year: 2001
    ..of ATP appearance outside the EC and its eventual conversion to adenosine is an important component of regional blood flow control in the normal heart...
  31. REGIONAL RENAL PERFUSION QUANTIFICATION WITH CU-62 PET
    Jeffrey Lacy; Fiscal Year: 2001
    ..With a suitable radioactive agent, PET imaging can provide absolute quantification of regional blood flow with excellent spatial resolution and can be applied conveniently in humans...
  32. MYOCARDIAL ISCHEMIA AND CORONARY ARTERY REPERFUSION
    STEPHEN VATNER; Fiscal Year: 2000
    ..reperfusion, as well as chronic coronary constriction induced with stenoses and ameroid devices, along with regional blood flow (radioactive microspheres. A second important feature is to measure regional myocardial function, i.e...
  33. ENDOTHELIUM SMOOTH MUSCLE SIGNALLING--CALCIUM AND NO
    LOTHAR BLATTER; Fiscal Year: 1999
    ..relaxing factor (EDRF), plays a major role in modulation of vascular tone, vasoreactivity and regional blood flow. Experiments are proposed to test hypotheses on the basic cellular mechanisms by which endothelium-..
  34. HYPERTENSION, CIRCUMVENTRICULAR ORGANS, NUTRIENTS
    DIANE HARTLE; Fiscal Year: 1990
    ..of blood pressure parameters, cardiac output, heart rate, stroke volume, total peripheral resistance and regional blood flow changes in SHR vs WKY rats...
  35. Effects of Botanicals on Cognition in Midlife Women
    Pauline Maki; Fiscal Year: 2005
    ..Findings of group differences in the patterns of brain activation (i.e., regional blood flow changes) will point to the brain areas subserving any treatment-related improvements in memory performance...
  36. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    STANLEY EVANS; Fiscal Year: 1990
    ..compounds, (b) evaluate the effectiveness of these compounds on peripheral dopamine receptors utilizing regional blood flow measurements (pulsed Doppler flowmeter) in rats and (c) further characterize the peripheral dopamine ..
  37. NICOTINE EFFECTS ON CEREBRAL BLOOD FLOW AND METABOLISM
    EDWARD DOMINO; Fiscal Year: 2001
    ..These are to determine the effects of nicotine in tobacco smoking amounts on (1 ) regional blood flow and (2) on regional glucose metabolism in the brains of adult cigarette smokers and (3) on males and ..
  38. AMLODIPINE TREATMENT FOR COCAINE DEPENDENCE
    Robert Malcolm; Fiscal Year: 2001
    ..deficits have been noted with lengthening abstinence from cocaine; however, recent work indicates that some regional blood flow changes are persistent over many months...
  39. QUANTITATION OF PERFUSION IN ISCHEMIC HEART DISEASE
    Steven Feinstein; Fiscal Year: 1991
    In this project it is proposed to determine the feasibility of measuring in vivo, noninvasively, the regional blood flow and regional blood volume of the myocardium using an ultrasonic contrast imaging approach...
  40. PERIPHERAL NEUROPATHY FOLLOWING THERMAL INJURY
    WILLIAM MONAFO; Fiscal Year: 1991
    ..The role of altered regional blood flow (NBF) and its interrelationships with endoneurial and wound edema comprise an important additional focus...
  41. OXYGEN METABOLISM AND RATE OF BLOOD FLOW
    Daniel Fiat; Fiscal Year: 2002
    ..It can noninvasively measure the regional metabolic rate of oxygen (rMR02) and regional blood flow (rBF) in many body organs, particularly, brain. There is no radiation exposure...
  42. VEGF INDUCED ANGIOGENESIS & VENTRICULAR REMODELING
    YS CHANDRASHEKHAR; Fiscal Year: 2001
    ..ventricular remodeling), a Sestamibi scan to estimate "area of risk" and microsphere injections to estimate regional blood flow. On day #3, Sestamibi scans will be repeated, a PET scan will be done to measure coronary flow (using 15O-..
  43. REG OF NITRIC OXIDE PRODUCT IN THE HEPATIC CIRCULATION
    Vijay Shah; Fiscal Year: 2002
    ..Shear stress is a physiologic biomechanical force which has been found to modulate regional blood flow through the regulation of endothelial cell production of vasodilator substances such as NO...
  44. High cGMP Alters Signal Transduction in Cardiac Failure
    Peter Scholz; Fiscal Year: 2005
    ..O2 consumption of the same area will be determined from regional blood flow and regional O2 saturation of hemoglobin (microspectrophotometry)...
  45. REGIONAL FLOW MEASUREMENT IN TUMORS
    CLYDE BARLOW; Fiscal Year: 2001
    ..is to develop a fully automated method and instrument for high-resolution three-dimensional mapping of regional blood flow distribution in tumors...
  46. SIMPLIFIED MEASUREMENT OF REGIONAL FLOW
    Jeffrey Kelly; Fiscal Year: 2002
    ..Description Verbatim): The goal of this project is to develop rapid, low-cost methods for determining regional blood flow in mammalian tissues and to make regional blood flow measurements more widely accessible to researchers ..
  47. ASSESSMENT OF DISEASE PROGRESSION IN PARKINSONISM
    David Eidelberg; Fiscal Year: 2003
    ..in the resting state; and (3) The quantification of dynamic changes in brain-behavior relationships using regional blood flow activation and network analysis...
  48. SIMPLIFIED MEASUREMENT OF REGIONAL FLOW
    Jeffrey Kelly; Fiscal Year: 1999
    ..of fluorescent microspheres injected into circulatory flow can be directly counted to determine regional blood flow. This technology would replace current indirect methods that estimate numbers of microspheres, that involve ..
  49. Functional MRI of the transplanted kidney
    Thomas Grist; Fiscal Year: 2007
    ..New MR techniques, termed functional MRI, can assess the filtration capacity of glomeruli, regional blood flow within the kidney, and the oxygen bioavailability at the tissue level...
  50. BRAIN MICROVASCULATURE IN AGING AND DEMENTIA
    Marcus Raichle; Fiscal Year: 1993
    ..microvascular function using positron emission tomography (PET) to study: 1) resting state measurements of regional blood flow, vascular permeability-surface area product and metabolism; 2) the response of the vasculature to ..
  51. CARDIOVASCULAR CONTROL DURING DYNAMIC EXERCISE
    George Ordway; Fiscal Year: 1990
    ..Cardiovascular variables, including regional blood flow distribution, will be measured during electrical stimulation in this subthalamic site...
  52. REGULATION OF CALCIUM ENTRY BY ENDOTHELIN
    Errol Lobo; Fiscal Year: 1993
    Vasoactive agents play a pivotal role in the autoregulation of regional blood flow and in the pathogenesis of hypertension and vasospasm...
  53. Renal Perfusion Quantification With 62CU PET
    Jeffrey Lacy; Fiscal Year: 2005
    ..With a suitable radioactive agent, PET imaging can provide absolute quantification of regional blood flow with excellent spatial resolution and can be applied conveniently in humans...
  54. Learning Related Modulation of Resting Brain Metabolism
    SANJEEV VAISHNAVI; Fiscal Year: 2010
    ..Determine the oxygen-glucose-index (OGI) throughout the brain using measurements of regional blood flow, oxygen consumption, and glucose consumption via PET...
  55. AUTONOMIC FUNCTION IN EXERCISE TRAINED HYPERTENSIVES
    STEPHEN DICARLO; Fiscal Year: 2000
    ..interaction of the arterial and cardiopulmonary baroreflex on the regulation of sympathetic nerve activity, regional blood flow, arterial pressure, heart rate and hormonal regulation (renin and arginine vasopressin) at rest and during ..
  56. PET AND THE FUNCTIONAL ANATOMY OF UNIPOLAR DEPRESSION
    Wayne Drevets; Fiscal Year: 1999
    ..PET scans obtained in these four phases will also be used to examine the effects of antidepressant drugs on regional blood flow and metabolism...
  57. SKELETAL MUSCLE DYSFUNCTION IN COPD
    David Systrom; Fiscal Year: 2004
    ..identified patients with abnormal skeletal muscle O2 extraction, we will seek to differentiate disorders of regional blood flow to the exercising limb from intrinsic abnormalities of the muscle mitochondrion as a cause and {determine ..
  58. NEUROLOGICAL CENTER: METABOLIC/DEGENERATIVE DISORDERS
    Robert Katzman; Fiscal Year: 1980
    ..Changes in regional blood flow that may serve as a measure of neuronal and metabolic dysfunction underlying psychological defects are ..
  59. DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN
    Margaret Bradley; Fiscal Year: 2005
    ..is to determine the relationship between activity in specific brain structures (as defined by changes in regional blood flow), reports of fear arousal, and the electrocortical, visceral, and somatic responses that occur when ..
  60. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001
    ..that infusion of radiotracers with the MIP in the freely moving animal allows imaging of acute changes in regional blood flow associated with brain activation...
  61. REGULATION OF RENAL HEMODYNAMICS
    LUIS NAVAR; Fiscal Year: 2006
    ..whole kidney function using standard techniques as well as single fiber needle laser-Soppler flowmetry for regional blood flow measurements, NO electrodes to determine interstitial NO activity, and microdialysis probes to assess ..
  62. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002
    ..that infusion of radiotracers with the MIP in the freely moving animal allows imaging of acute changes in regional blood flow associated with brain activation...
  63. MICROVASCULAR VASOACTIVITY IN THE RENAL MEDULLA
    ERIK SILLDORFF; Fiscal Year: 2001
    ..blood flow in vivo; 3) to determine the effects of changes in sodium diet on renal adenosine levels and regional blood flow in the kidney and; 4) to map adenosine receptor subtypes in tubular and vascular structures in the renal ..
  64. ALCOHOL IN RISK BEHAVIORS AND NEUROBEHAVIORAL STATUS
    Hector Myers; Fiscal Year: 2000
    ..will examine, also, the role of alcohol in neurophysiologic status and functioning as indexed by regional blood flow (rCBF) in a stratified sample of 118 HIV-positive and HIV-negative men using state-of-the-art neuroimaging ..