placental circulation

Summary

Summary: The circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA.

Top Publications

  1. ncbi Bilateral notching of uterine arteries at 12--14 weeks of gestation for prediction of hypertensive disorders of pregnancy
    Merja Vainio
    Department of Obstetrics and Gynecology, Hyvinkaa Hospital, Hyvinkaa, Finland
    Acta Obstet Gynecol Scand 84:1062-7. 2005
  2. ncbi [The usefulness of uterine artery doppler velocimetry in high risk pregnancy diagnostic (PIH and/or IUGR)]
    Piotr Sieroszewski
    Instytut Ginckologii i Poloznictwa Uniwersytetu Medycznego w Lodzi
    Ginekol Pol 76:342-7. 2005
  3. ncbi Role of placental growth hormone in the alteration of maternal arterial resistance in pregnancy
    Barbara Schiessl
    Prenatal Medicine Unit, Department of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany
    J Reprod Med 52:313-6. 2007
  4. ncbi Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction
    F Crispi
    Department of Obstetrics, Fetal Medicine Unit, Barcelona, Spain
    Ultrasound Obstet Gynecol 31:303-9. 2008
  5. ncbi Stress and placental resistance measured by Doppler ultrasound in early and mid-pregnancy
    E W Harville
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Ultrasound Obstet Gynecol 32:23-30. 2008
  6. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
  7. ncbi Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus
    Vanessa E Murphy
    Mothers and Babies Research Centre, and Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Endocr Rev 27:141-69. 2006
  8. ncbi Evolutionary transformations of fetal membrane characters in Eutheria with special reference to Afrotheria
    Andrea Mess
    Institut für Systematische Zoologie, Museum für Naturkunde, Humboldt Universitat Berlin, DE 10115 Berlin, Germany
    J Exp Zool B Mol Dev Evol 306:140-63. 2006
  9. ncbi Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:604-11. 2007
  10. pmc Does antenatal maternal psychological distress affect placental circulation in the third trimester?
    Anne Helbig
    Norwegian Resource Centre for Women s Health, Oslo University Hospital, Oslo, Norway
    PLoS ONE 8:e57071. 2013

Detail Information

Publications227 found, 100 shown here

  1. ncbi Bilateral notching of uterine arteries at 12--14 weeks of gestation for prediction of hypertensive disorders of pregnancy
    Merja Vainio
    Department of Obstetrics and Gynecology, Hyvinkaa Hospital, Hyvinkaa, Finland
    Acta Obstet Gynecol Scand 84:1062-7. 2005
    ..To assess the value of transvaginal uterine artery Doppler ultrasound at 12--14 weeks of gestation in predicting hypertensive disorders of pregnancy in high-risk women...
  2. ncbi [The usefulness of uterine artery doppler velocimetry in high risk pregnancy diagnostic (PIH and/or IUGR)]
    Piotr Sieroszewski
    Instytut Ginckologii i Poloznictwa Uniwersytetu Medycznego w Lodzi
    Ginekol Pol 76:342-7. 2005
    ..High risk pregnancy was defined as developing of pregnancy induced hypertension or/and growth retardation in the course of gestation...
  3. ncbi Role of placental growth hormone in the alteration of maternal arterial resistance in pregnancy
    Barbara Schiessl
    Prenatal Medicine Unit, Department of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany
    J Reprod Med 52:313-6. 2007
    ..To investigate the relation between arterial resistance and placental growth hormone (hGH-V) levels in the maternal circulation...
  4. ncbi Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction
    F Crispi
    Department of Obstetrics, Fetal Medicine Unit, Barcelona, Spain
    Ultrasound Obstet Gynecol 31:303-9. 2008
    ....
  5. ncbi Stress and placental resistance measured by Doppler ultrasound in early and mid-pregnancy
    E W Harville
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Ultrasound Obstet Gynecol 32:23-30. 2008
    ....
  6. ncbi Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia
    Peter Kaufmann
    Department of Anatomy II, University of Technology Aachen, D 52057 Aachen, Germany
    Biol Reprod 69:1-7. 2003
    ..e., the placental bed...
  7. ncbi Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus
    Vanessa E Murphy
    Mothers and Babies Research Centre, and Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Endocr Rev 27:141-69. 2006
    ..Endocrine regulation of fetal growth involves interactions between the mother, placenta, and fetus, and these effects may program long-term physiology...
  8. ncbi Evolutionary transformations of fetal membrane characters in Eutheria with special reference to Afrotheria
    Andrea Mess
    Institut für Systematische Zoologie, Museum für Naturkunde, Humboldt Universitat Berlin, DE 10115 Berlin, Germany
    J Exp Zool B Mol Dev Evol 306:140-63. 2006
    ..e., the occurrence of a four-lobed allantoic sac. Thus, contrary to previous assertions, it is possible to identify morphological characters that could be synapomorphic for this novel taxon...
  9. ncbi Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:604-11. 2007
    ..We also showed that AT1 autoantibodies cross the ureteroplacental barrier. These components could participate in the pathophysiology of preeclampsia...
  10. pmc Does antenatal maternal psychological distress affect placental circulation in the third trimester?
    Anne Helbig
    Norwegian Resource Centre for Women s Health, Oslo University Hospital, Oslo, Norway
    PLoS ONE 8:e57071. 2013
    ..Our objective was to study whether specific types of maternal psychological distress affect the placental circulation, using volume blood flow quantification in addition to arterial resistance measures.
  11. ncbi Doppler-derived umbilical artery absolute velocities and their relationship to fetoplacental volume blood flow: a longitudinal study
    G Acharya
    Department of Obstetrics and Gynecology, University Hospital of Northern Norway, Tromsø, Norway
    Ultrasound Obstet Gynecol 25:444-53. 2005
    ....
  12. ncbi Psychological distress after recent detection of fetal malformation: short-term effect on second-trimester uteroplacental and fetoplacental circulation
    A Helbig
    Department of Obstetrics, Oslo University Hospital, Oslo, Norway
    BJOG 118:1653-7. 2011
    We examined the short-term effect of severe maternal psychological distress on the placental circulation in second trimester in a prospective observational study...
  13. ncbi Placental circulation: Clinical significance
    M Zygmunt
    Department of Obstetrics and Gynecology, University of Giessen, Germany
    Early Pregnancy 5:72-3. 2001
    ....
  14. ncbi Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies
    Libor Hradecky
    Department of Gynecology and Obstetrics, Charles University and Faculty Hospital, Pilsen, Czech Republic
    Am J Reprod Immunol 62:412-7. 2009
    ....
  15. pmc Angiotensin II regulation of ovine fetoplacental artery endothelial functions: interactions with nitric oxide
    Jing Zheng
    Department of Obstetrics, Perinatal Research Laboratories, University of Wisconsin, 7E Meriter Hospital, Madison, WI 53715, USA
    J Physiol 565:59-69. 2005
    ..The potential cellular mechanisms underlying the regulation of Ang II on endothelial growth and vasodilator production are discussed...
  16. pmc A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia
    Nathan M Hunkapiller
    Center for Reproductive Sciences, University of California San Francisco, CA 94143, USA
    Development 138:2987-98. 2011
    ..In pre-eclampsia, expression of the Notch ligand JAG1 was absent in perivascular and endovascular TBs. We conclude that Notch signaling is crucial for TB vascular invasion...
  17. ncbi Functional link between adenosine and insulin: a hypothesis for fetoplacental vascular endothelial dysfunction in gestational diabetes
    Enrique Guzmán-Gutiérrez
    Cellular and Molecular Physiology Laboratory and Perinatology Research Laboratory, Division of Obstetrics and Gynaecology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Vasc Pharmacol 9:750-62. 2011
    ....
  18. ncbi Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature
    Thomas Walther
    Department of Cardiology and Pneumology, Charite Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:1275-9. 2005
    ..The generation of this antibody seems to be associated with distinct types of pregnancy disorders resulting from impaired placental development. The AT1 autoantibody may thus be causative for pathological uteroplacental perfusion...
  19. ncbi Physiological dilation of uteroplacental arteries in the guinea pig depends on nitric oxide synthase activity of extravillous trophoblast
    A Nanaev
    , RWTH Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Cell Tissue Res 282:407-21. 1995
    ....
  20. ncbi Shunting the intervillous space: new concepts in human uteroplacental vascularization
    Jean Pierre Schaaps
    Department of Obstetrics and Gynecology, CHR de la Citadelle, Liege, Belgium
    Am J Obstet Gynecol 192:323-32. 2005
    ..We therefore attempted to provide arguments for a functional vascular anastomotic network located in the placental bed during human pregnancy...
  21. ncbi Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta
    J C Cross
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, HSC Room 2279, 3330 Hospital Drive, N W, Alta, T2N 4N1, Calgary, Canada
    Mol Cell Endocrinol 187:207-12. 2002
    ..As in primates, murine trophoblast cells also invade into the uterine arteries of the mother. However, in normal pregnancy, dilation of the uterine arteries may be largely mediated by the effect of uterine natural killer cells...
  22. ncbi Prognostic value of placental ultrasound in pregnancies complicated by absent end-diastolic flow velocity in the umbilical arteries
    S Viero
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Placenta 25:735-41. 2004
    ..Ultrasound examination of the placenta and its maternal blood supply may contribute to the perinatal management of these pregnancies...
  23. ncbi Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta
    S Lee Adamson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Dev Biol 250:358-73. 2002
    ..These studies provide important insights into how the fetoplacental unit interacts with the maternal intrauterine vascular system during pregnancy in mice...
  24. ncbi The human placental bed revisited
    F Lyall
    Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
    Placenta 23:555-62. 2002
    ....
  25. ncbi Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep
    A L David
    Prenatal Gene Therapy Group, Institute for Women s Health, Royal Free and University College London Medical School, London, UK
    Gene Ther 15:1344-50. 2008
    ..11+/-0.01 vs 8.65+/-0.11, P<0.05). Injection of Ad.VEGF-A into the UtAs increases UBF by enhancing vasodilatation. This may provide the basis for therapy in pregnancies complicated by uteroplacental insufficiency...
  26. pmc IgG is transported across the mouse yolk sac independently of FcgammaRIIb
    Sudhasri Mohanty
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Reprod Immunol 84:133-44. 2010
    ..It is not clear whether RIIb in the human placental villus might mediate an IgG transport function in light of the mouse yolk sac equivalent failing to do so...
  27. ncbi The mechanisms and regulation of placental amino acid transport to the human foetus
    J K Cleal
    The Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Neuroendocrinol 20:419-26. 2008
    ..Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy...
  28. ncbi Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia
    N Geusens
    Department of Woman and Child, Katholieke Universiteit Leuven, Leuven, Belgium
    Placenta 29:614-23. 2008
    ..We conclude that in this transgenic PE rat model there is deeper endovascular invasion of spiral arteries and decreased RI of uterine arteries at day 18 of pregnancy...
  29. ncbi Vessel tortuousity and reduced vascularization in the fetoplacental arterial tree after maternal exposure to polycyclic aromatic hydrocarbons
    Monique Y Rennie
    Mouse Imaging Centre, Hospital for Sick Children, and Department of Medical Biophysics, Institute of Medical Studies, University of Toronto, 25 Orde St, Toronto, ON, Canada M5T 3H7
    Am J Physiol Heart Circ Physiol 300:H675-84. 2011
    ..New insights into the specific effects of PAH exposure on a developing arterial tree were achieved using micro-CT imaging and automated vascular segmentation analysis...
  30. ncbi Development of the utero-placental circulation: the role of carbon monoxide and nitric oxide in trophoblast invasion and spiral artery transformation
    Fiona Lyall
    Maternal and Fetal Medicine Section, University of Glasgow Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, United Kingdom
    Microsc Res Tech 60:402-11. 2003
    ..Current evidence supports the idea that trophoblast-derived carbon monoxide may contribute to spiral artery modification. In contrast there is no evidence for a similar role by nitric oxide...
  31. ncbi Uteroplacental hemodynamics during early human pregnancy: a longitudinal study
    K Mäkikallio
    Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland
    Gynecol Obstet Invest 58:49-54. 2004
    ..To determine normal physiologic changes in the uteroplacental hemodynamics during early placental development in the first trimester of pregnancy...
  32. ncbi Short-term effects of glucocorticoids in the human fetal-placental circulation in vitro
    Vicki L Clifton
    Mothers and Babies Research Centre, Department of Endocrinology, John Hunter Hospital, Hunter Region Mail Center, Newcastle, New South Wales 2310, Australia
    J Clin Endocrinol Metab 87:2838-42. 2002
    ..We have examined whether the short-term administration of glucocorticoids into the human fetal-placental circulation affects placental arterial pressure and alters vascular responses to vasoconstrictive and vasodilator ..
  33. ncbi Vascular corrosion casting of the uteroplacental and fetoplacental vasculature in mice
    Kathie J Whiteley
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Methods Mol Med 121:371-92. 2006
    ..The methods described have been used to cast the mouse uteroplacental vasculature from 5.5-18.5 d gestation and the fetoplacental vasculature from 12.5 d gestation to term...
  34. ncbi Placental circulation, fetal growth, and stiffness of the abdominal aorta in newborn infants
    Mori Akira
    Department of Obstetrics and Gynecology, Tokai University School of Medicine, Boseidai, Isehara City, Kanagawa, Japan
    J Pediatr 148:49-53. 2006
    ..To measure the elastic properties of the abdominal aorta in normal infants and infants who had umbilical placental insufficiency (UPI) before birth...
  35. ncbi Uteroplacental insufficiency after bilateral uterine artery ligation in the rat: impact on postnatal glucose and lipid metabolism and evidence for metabolic programming of the offspring by sham operation
    Kai Dietrich Nüsken
    Department of Pediatrics, Nikolaus Fiebiger Centre of Molecular Medicine, University Erlangen Nuernberg, Loschgestrasse 15, 91054 Erlangen, Germany
    Endocrinology 149:1056-63. 2008
    ..Visfatin does not appear to be involved in the disturbed glucose metabolism after intrauterine growth restriction and may represent only a marker of fat accumulation...
  36. ncbi Antenatal sonographic detection of an unusual placental lake under the cord insertion
    Recep Has
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Istanbul, 9 Kisim B 18 Daire 52 Atakoy, 34750 Istanbul, Turkey
    Arch Gynecol Obstet 271:59-61. 2005
    ..This extraordinarily huge lake showed an interesting dynamic appearance on sonographic examination...
  37. pmc Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis
    Jeltsje S Cnossen
    Department of General Practice, Academic Medical Center, Amsterdam, The Netherlands
    CMAJ 178:701-11. 2008
    ..We investigated the predictive accuracy of all uterine artery Doppler indices for both conditions in the first and second trimesters...
  38. ncbi Myometrial and placental artery reactivity alone cannot explain reduced placental perfusion in pre-eclampsia and intrauterine growth restriction
    Stephen S Ong
    The MRC Development Group, School of Human Development, University of Nottingham, Maternity Unit, City Hospital, UK
    BJOG 110:909-15. 2003
    ..2) To confirm that myometrial arteries from women with pre-eclampsia and intrauterine growth restriction exhibit an attenuated endothelium-dependent vasodilatory response...
  39. ncbi Non-placental causes of intrauterine growth restriction
    Nancy Hendrix
    Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Semin Perinatol 32:161-5. 2008
    ..Knowledge of the etiologies of fetal growth restriction is essential, so that future care can be targeted at prevention. There are several primary and secondary prevention strategies that can be adopted...
  40. ncbi Increasing cardiac output and decreasing oxygenation sequence in pump twins of acardiac twin pregnancies
    Martin J C van Gemert
    Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Phys Med Biol 50:N33-42. 2005
    ....
  41. ncbi The importance of Doppler ultrasound in delivery planning
    M Gojnic
    Institute of Gynecology and Obstetrics, University of Belgrade, Serbia
    Clin Exp Obstet Gynecol 31:282-4. 2004
    ..However, the danger of walking on a tightrope is decreased if it is anticipated that delivery can not be accomplished per vias naturalis and that it is more advisable and safer to perform cesarean section...
  42. ncbi Association between abnormal uterine artery Doppler flow velocimetry, risk of preeclampsia, and indices of arterial structure and function: a pilot study
    Eleftherios Anastasakis
    1st Department of Obstetrics and Gynaecology, Alexandra Maternity Hospital, University of Athens, Greece
    Angiology 59:493-9. 2008
    ..0079) compared with those with normal uteroplacental flow. Women with abnormal uterine artery Doppler results may be at increased risk not only for developing subsequent preeclampsia but also for future cardiovascular disease...
  43. ncbi Ultrasound diagnosis of severe thrombotic placental damage in the second trimester: an observational study
    F Alkazaleh
    Placenta Clinic, Maternal Fetal Medicine Division, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Ultrasound Obstet Gynecol 23:472-6. 2004
    ....
  44. ncbi Reduced antioxidant capacity in second-trimester pregnancies with pathological uterine perfusion
    H Stepan
    Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Ultrasound Obstet Gynecol 23:579-83. 2004
    ....
  45. ncbi Sonographic atypical vascular coiling of the umbilical cord
    Antonella Cromi
    Department of Obstetrics and Gynecology, University of Insubria F Del Ponte Hospital, Varese, Italy
    Prenat Diagn 25:1-6. 2005
    ..To investigate whether an atypical umbilical coiling pattern at prenatal sonography is associated with adverse pregnancy outcome...
  46. ncbi The value of uterine artery Doppler ultrasound in the prediction of severe complications in a risk population
    R Axt-Fliedner
    Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Arch Gynecol Obstet 271:53-8. 2005
    ....
  47. ncbi Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women
    Giorgio Mello
    Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Viale GB Morgagni 85, 50134 Florence, Italy
    Hypertension 45:86-91. 2005
    ..LMWH reduces the recurrence of preeclampsia, of negative outcomes, and the resistance of uteroplacental flow, and also prevents maternal blood pressure increase in ACE DD homozygote women with a previous history of preeclampsia...
  48. ncbi Doppler ultrasound of the uterine artery in the prediction of severe complications during low-risk pregnancies
    A Schwarze
    Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Arch Gynecol Obstet 271:46-52. 2005
    ....
  49. ncbi Sequential changes in uterine artery blood flow pattern between the first and second trimesters of gestation in relation to pregnancy outcome
    O Gomez
    Department of Obstetrics and Gynaecology, ICGON, Hospital Clinic, Barcelona, Spain
    Ultrasound Obstet Gynecol 28:802-8. 2006
    ..To describe sequential changes in uterine artery waveform between the first and second trimesters of gestation and to analyze their association with the subsequent risk of hypertensive disorders and fetal growth restriction (IUGR)...
  50. ncbi [Pregnancy complications can impair placental transport systems. Aberrant fetal growth, for example in diabetes, is only now beginning to be understood]
    Thomas Jansson
    Institutionen för fysiologi och farmakologi, Sahlgrenska akademin, Göteborgs Universitet
    Lakartidningen 100:2508-11. 2003
    ....
  51. ncbi [Morphological diagnosis of placental pathology in uterine contraction disorders]
    S A Sharygin
    Arkh Patol 67:25-7. 2005
    ....
  52. ncbi Morphologic changes of the uteroplacental unit in preeclampsia-like syndrome in rats
    Andreas J Mayr
    Department of Anaesthesia and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    Hypertens Pregnancy 24:29-37. 2005
    ..This animal study aims to determine whether L-NAME-induced preeclampsia-like syndrome is also associated with morphologic changes in the uteroplacental unit...
  53. ncbi Fetal brain sparing is strongly related to the degree of increased placental vascular impedance
    Riffat Cheema
    Department of Obstetrics and Gynecology, Malmo University Hospital, Malmo, Sweden
    J Perinat Med 34:318-22. 2006
    ..Doppler ultrasound examination has become an established method of clinical surveillance in high-risk pregnancies. Doppler indication of fetal brain sparing (BS) is an acknowledged sign of circulation redistribution during chronic hypoxia...
  54. ncbi Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia
    Anuja Dokras
    Department of Obstetrics and Gynecology, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Biol Reprod 75:899-907. 2006
    ....
  55. ncbi Evaluation of third trimester uterine artery flow velocity indices in relationship to perinatal complications
    G Ghosh
    Department of Obstetrics and Gynecology, Malmo University Hospital, Malmo, Sweden
    J Matern Fetal Neonatal Med 19:551-5. 2006
    ..The aim of the present study was to evaluate the different indices in the prediction of adverse outcome of pregnancies suspected for intrauterine fetal growth restriction (IUGR)...
  56. ncbi State of the art: non-invasive ultrasound assessment of the uteroplacental circulation
    Gabriele Urban
    Department of Obstetrics and Gynecology, University of Milan Bicocca, San Gerardo Hospital, Monza, Italy
    Semin Perinatol 31:232-9. 2007
    ..Currently we are able to characterize uteroplacental perfusion with quantitative and qualitative methodologies. This review will examine both methodologies and seek to highlight conclusive and inconclusive findings...
  57. ncbi Placental vascularization measured by three-dimensional power Doppler ultrasound at 11 to 13 + 6 weeks' gestation in normal and aneuploid fetuses
    G Rizzo
    Department of Obstetrics and Gynecology, Universita di Roma Tor Vergata, Rome, Italy
    Ultrasound Obstet Gynecol 30:259-62. 2007
    To establish the potential role of three-dimensional (3D) power Doppler evaluation of the placental circulation in aneuploidy screening at 11 to 13 + 6 weeks of gestation.
  58. ncbi Measurement of placental oxygenation by transabdominal near-infrared spectroscopy
    Takakazu Kawamura
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Perinatol 24:161-6. 2007
    ..8 +/- 1.6 [SD] versus 70.3 +/- 0.4 [SD]). We propose that NIRS is a candidate, noninvasive method for assessing placental oxygen dynamics on a real-time basis. In the near future it may contribute to perinatal medical practice...
  59. ncbi Pregnancy on intensified hemodialysis: fetal surveillance and perinatal outcome
    Christian Bamberg
    Department of Obstetrics and Gynecology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Fetal Diagn Ther 22:289-93. 2007
    ..To evaluate the effect of intensive fetal surveillance via Doppler ultrasound and fetal non-stress test on the perinatal outcome of pregnant women undergoing an intensified hemofiltration scheme...
  60. ncbi Mean platelet volume: association with adverse neonatal outcome
    S Gioia
    Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy
    Platelets 18:284-8. 2007
    ..7%, 95 CI: 18.8-66, p < 0.01). Our study suggests that pregnancies affected by Doppler velocimetry alterations, an MPV value > or = 10 fl may be associated with severe oxygen support and/or low UA ph at birth...
  61. ncbi Fetal cardiac output, distribution to the placenta and impact of placental compromise
    T Kiserud
    Department of Clinical Medicine, Section of Obstetrics and Gynaecology, University of Bergen, Bergen, Norway
    Ultrasound Obstet Gynecol 28:126-36. 2006
    ..Our aim was to determine the normal distribution of fetal cardiac output to the placenta during the second half of pregnancy, and to assess the changes imposed by growth restriction with various degrees of placental compromise...
  62. ncbi [Uterine pathomorphology in abruptio placentae]
    A P Milovanov
    Arkh Patol 68:25-7. 2006
    ..These factors result in the formation of retroplacental hematoma and progressing intrauterine fetal hypoxia...
  63. ncbi Effects of maternal hyperoxia with and without normocapnia in uteroplacental and fetal Doppler studies
    M J Simchen
    Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel
    Ultrasound Obstet Gynecol 26:495-9. 2005
    ..We aimed to evaluate the effect of maternal hyperoxygenation with and without maintaining normocapnia on the fetal and uteroplacental circulations in healthy near-term human pregnancies...
  64. ncbi The role of uterine artery Doppler in predicting adverse pregnancy outcome
    Aris T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London SE5 8RX, UK
    Best Pract Res Clin Obstet Gynaecol 18:383-96. 2004
    ....
  65. ncbi Is three-dimensional power Doppler ultrasound useful in the assessment of placental perfusion in normal and growth-restricted pregnancies?
    C Guiot
    Department of Neurosciences and CNISM, University of Turin, C Raffaello 30, Turin, Italy
    Ultrasound Obstet Gynecol 31:171-6. 2008
    ....
  66. ncbi Uterine artery Doppler screening for adverse pregnancy outcome
    Aris T Papageorghiou
    Fetal Medicine Unit, St George s Hospital, London, UK
    Curr Opin Obstet Gynecol 17:584-90. 2005
    ..This article reviews publications in the area of uterine artery Doppler screening that were published during the past year...
  67. ncbi Prediction of pre-eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small-for-gestational age
    C K H Yu
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 31:310-3. 2008
    ..To determine the relationship between pre-eclampsia, small-for-gestational age (SGA) and gestational age at delivery, and the effect of this relationship on the prediction of pre-eclampsia by uterine artery Doppler imaging...
  68. ncbi Doppler, cardiotocography, and biophysical profile changes in growth-restricted fetuses
    Erich Cosmi
    Department of Gynecological Science, Section of Maternal Fetal Medicine, University of Padua School of Medicine, Padova, Italy
    Obstet Gynecol 106:1240-5. 2005
    ..To assess from diagnosis to delivery the Doppler studies of the umbilical artery, middle cerebral artery, umbilical vein, ductus venosus, and amniotic fluid index of fetuses with idiopathic growth restriction...
  69. ncbi Effect of a cholesterol-lowering diet during pregnancy on maternal and fetal Doppler velocimetry: the CARRDIP study
    Janette Khoury
    Department of Obstetrics and Gynecology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Am J Obstet Gynecol 196:549.e1-7. 2007
    ..The purpose of this study was to evaluate the effect of a low-cholesterol low-saturated fat diet on Doppler indices in the fetus and mother...
  70. ncbi Maternal-fetal flow, negative events, and preeclampsia: role of ACE I/D polymorphism
    Giorgio Mello
    Department of Gynecology, Perinatology, and Human Reproduction, University of Florence, Florence, Italy
    Hypertension 41:932-7. 2003
    ..The current study shows that the ACE I/D polymorphism affects uteroplacental and umbilical flows and the recurrence of an adverse pregnancy outcome in women with history of preeclampsia...
  71. ncbi Nitrotyrosine immunostaining correlates with increased extracellular matrix: evidence of postplacental hypoxia
    J Stanek
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0529, USA
    Placenta 22:S56-62. 2001
    ..NT immunostaining may therefore help differentiate those cases of perinatal morbidity/mortality associated with post-placental hypoxia provided that the secondary impact of intrauterine fetal death can be excluded by future studies...
  72. ncbi Prognostic factors for survival of growth-restricted fetuses with absent end-diastolic velocity in the umbilical artery
    Riza Madazli
    Department of Obstetrics and Gynaecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    J Perinatol 22:286-90. 2002
    ..The aim of the study was to evaluate the prognostic factors for survival of growth-restricted fetuses with absent end-diastolic velocity in the umbilical artery...
  73. ncbi Uterine artery Doppler at 11-14 weeks of gestation in chromosomally abnormal fetuses
    R Bindra
    Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK
    Ultrasound Obstet Gynecol 18:587-9. 2001
    ..CONCLUSIONS: The high intrauterine lethality and fetal growth restriction associated with the major chromosomal abnormalities are unlikely to be the consequence of impaired placentation in the first trimester of pregnancy...
  74. ncbi The effect of isosorbide dinitrate on placental blood flow and maternal blood pressure in women with pregnancy induced hypertension
    I Thaler
    Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel
    Am J Hypertens 12:341-7. 1999
    ..Our finding that ISDN altered maternal and fetal hemodynamics in PIH lends support to the further exploration of nitric oxide donors in the treatment and prevention of pregnancy induced hypertension...
  75. ncbi Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11-14 weeks of gestation
    A M Martin
    Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK
    Ultrasound Obstet Gynecol 18:583-6. 2001
    ..0% and 27.8%, respectively. CONCLUSION: Uterine artery Doppler at 11-14 weeks of gestation identifies a high proportion of women who develop severe pre-eclampsia and/or fetal growth restriction...
  76. ncbi The effect of methyldopa treatment on uterine, umblical and fetal middle cerebral artery blood flows in preeclamptic patients
    O Günenç
    Department of Obstetrics and Gyneacology, Selcuk University School of Medicine, Selcuk Universitesi Tip Fakültesi Kadin Hastaliklari ve Dogum ABD, Konya, Turkiye
    Arch Gynecol Obstet 266:141-4. 2002
    ..Treatment with methyldopa lowered the uterine artery resistance in preeclamptic patients but did not effect the resistance of umblical and fetal middle cerebral artery...
  77. ncbi Clotting and hemorrhage in the placenta--a delicate balance
    Drucilla Roberts
    N Engl J Med 347:57-9. 2002
  78. ncbi [The role of uterine and umbilical artery Doppler velocimetry for the early detection of pathologic pregnancy]
    J Aranyosi
    Debreceni Egyetem, , ,
    Orv Hetil 142:727-31. 2001
    ..The clinical benefits of this screening method will be precisely defined on the basis of further multicenter studies in Hungary...
  79. ncbi Randomised comparison of uterine artery Doppler and aspirin (100 mg) with placebo in nulliparous women: the Essai Régional Aspirine Mère-Enfant study (Part 2)
    Damien Subtil
    BJOG 110:485-91. 2003
    ....
  80. pmc Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London
    Am J Pathol 162:115-25. 2003
    Onset of the maternal-placental circulation was studied by Doppler ultrasonography in 65 pairs of age-matched normal and abnormal pregnancies...
  81. ncbi Three-dimensional sonography for assessment of morphology and vascularization of the fetus and placenta
    A Kurjak
    Department of Obstetrics and Gynecology, Medical School University of Zagreb, Sveti Duh Hospital, Croatia
    J Soc Gynecol Investig 9:186-202. 2002
    ..To analyze the potential of three-dimensional power Doppler sonography in morphologic and functional assessment of the fetus and placenta...
  82. ncbi Intrauterine growth restriction
    Karel Marsal
    Department of Obstetrics and Gynecology, University Hospital Lund, Lund University, Lund, Sweden
    Curr Opin Obstet Gynecol 14:127-35. 2002
    ..Evaluation of fetal state before 32 weeks is difficult and should include Doppler examination of placental circulation and several fetal arterial and venous vessel beds...
  83. pmc Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro
    Jane K Cleal
    DOHaD Division, University of Southampton, Southampton, UK
    J Physiol 582:871-82. 2007
    ..This study investigates the substrate specificity of exchange between the placenta and the feto-placental circulation. Maternal-fetal transfer of radiolabelled amino acids and creatinine were measured in the isolated ..
  84. ncbi Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia
    S Mizutani
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan
    Am J Hypertens 9:591-7. 1996
    ..and angiotensin are known to play an important role in normal and aberrant (preeclampsia) fetal-placental circulation, the clearance of these peptides in the placenta is important in controlling fetal blood pressure...
  85. pmc Effects of captopril on the human foetal placental circulation: an interaction with bradykinin and angiotensin I
    R de Moura
    Departamento de Farmacologia e Psicobiologia, IB HUPE, Universidade do Estado do Rio de Janeiro, Brasil
    Br J Clin Pharmacol 39:497-501. 1995
    ..Since bradykinin and angiotensin II appear to be important in the regulation of the placental circulation, experiments were performed to assess the effects of captopril on the vascular actions of these peptides ..
  86. ncbi Effect of propofol on human fetal placental circulation
    R Soares de Moura
    Departamento de Farmacologia e Psicobiologia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Brasil
    Int J Obstet Anesth 19:71-6. 2010
    ..The direct effect of propofol on the fetal placental circulation was studied in vitro...
  87. pmc Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta
    L Myatt
    Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Placenta 31:S66-9. 2010
    ..The presence of nitrative stress was associated with diminished vascular reactivity of the fetal placental circulation, a situation that could be reproduced by treatment with peroxynitrite in vitro...
  88. ncbi Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance
    Diarmaid D Houlihan
    Department of Obstetrics and Gynecology, Clinical Sciences Institute, National University of Ireland Galway, University College Hospital, Galway, Ireland
    J Perinat Med 32:315-9. 2004
    ..To investigate and compare the direct effects of compounds used in the treatment of hypertensive disease in pregnancy on human umbilical artery resistance in vitro...
  89. ncbi Neurokinin B is a paracrine vasodilator in the human fetal placental circulation
    P Brownbill
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester M13 0JH, United Kingdom
    J Clin Endocrinol Metab 88:2164-70. 2003
    ..We hypothesized that NKB is a paracrine modulator of tone in the fetal placental circulation. We tested this hypothesis using the in vitro perfused human placental cotyledon...
  90. ncbi Vascular effects of PTHrP (1-34) and PTH (1-34) in the human fetal-placental circulation
    K MacGill
    Department of Perinatal Medicine, Royal Women s Institute of Medical Research, Fitzroy, Victoria, Australia
    Placenta 18:587-92. 1997
    ..parathyroid hormone-related protein (PTHrP) (1-34) and parathyroid hormone (PTH) (1-34) on the human fetal-placental circulation utilising an in vitro placental perfusion model...
  91. ncbi Indomethacin activity in the fetal vasculature of normal and meconium exposed human placentae
    G Holcberg
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Science, Ben Gurion University of the Weger, P O Box 151, Beer Sheva 84101, Israel
    Eur J Obstet Gynecol Reprod Biol 94:230-3. 2001
    ..To study the effect of indomethacin on the vasculature of isolated perfused human placental cotyledon in normal and meconium pretreated placentae...
  92. ncbi Protein C, protein S, and thrombomodulin in amniotic fluid. A preliminary study
    Mieczysław Uszyński
    Department of Propedeutics of Medicine, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
    J Perinat Med 34:289-92. 2006
    ..thrombomodulin (TM); the system plays a protective role in pregnancy, mainly because it prevents the utero-placental circulation from local thrombosis. It is unknown whether the protein C anticoagulant pathway exists in amniotic fluid...
  93. ncbi Residual anastomoses after fetoscopic laser surgery in twin-to-twin transfusion syndrome: frequency, associated risks and outcome
    E Lopriore
    Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Placenta 28:204-8. 2007
    ..The aim of fetoscopic laser surgery is to separate completely the inter-twin placental circulation. Incomplete laser coagulation may result in residual vascular anastomoses...
  94. ncbi Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis
    T Dudding
    Hunter Genetics, Hunter New England Health Service, NSW, Australia
    J Thromb Haemost 6:1869-75. 2008
    ..system as any perturbation in the balance of thrombotic and thrombolytic cascades could affect the placental circulation and hence the viability of the developing fetus...
  95. pmc Congenital Cervical Teratoma:Anaesthetic Management (The EXIT Procedure)
    Ferruh Bilgin
    Gulhane Military Medical Faculty, Department of Anesthesiology and Reanimation
    Indian J Anaesth 53:678-82. 2009
    ..intrapartum treatment (EXIT) is a procedure performed during caesarean section with preservation of fetal-placental circulation, which allows the safe handling of fetal airways with risk of airways obstruction...
  96. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  97. ncbi Effect of nitric oxide on the transport and release of oxygen in fetal blood
    Maria Elisabetta Clementi
    CNR Institute Chimica del riconoscimento Molecolare, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Biochem Biophys Res Commun 302:515-9. 2003
    ..vasodilator agent, plays an important role in lowering vascular resistance in the human umbilical-placental circulation and that its deficiency is related to the pathogenesis of pre-eclamptic disorder...
  98. ncbi Differential expression of the receptor tyrosine kinase EphB4 and its ligand Ephrin-B2 during human placental development
    C S Chennakesava
    Department of Clinical Research, University of Berne, Tiefenaustrasse 120, CH 3004 Berne, Switzerland
    Placenta 27:959-67. 2006
    Normal placentation involves the development of an utero-placental circulation following the migration of the extravillous cytotrophoblasts into the decidua and invasion of the spiral arteries, which are thereby transformed into large ..
  99. ncbi [Evidence that periplacentary leukocytes subpopulations of term pregnancy have functional properties associated with labor induction]
    Arturo Flores Pliego
    Departamento de Especialidades Médicas, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Lomas de Virreyes, Mexico
    Ginecol Obstet Mex 76:45-51. 2008
    ....
  100. ncbi A proinflammatory cytokine response is present in the fetal placental vasculature in placental insufficiency
    Xin Wang
    Department of Obstetrics and Gynaecology, University of Sydney at Westmead Hospital, PO Box 533, Wentworthville, Westmead, NSW 2145, Australia
    Am J Obstet Gynecol 189:1445-51. 2003
    Vascular disease in the umbilical placental circulation is associated with fetal growth restriction and adverse outcome. It may be identified antenatally by the study of umbilical artery Doppler flow velocity waveforms...
  101. pmc Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation
    James Jarman
    Department of Anaesthesia, Clinical Sciences Institute, National University of Ireland, Galway Ireland
    BMC Anesthesiol 9:4. 2009
    ..We aimed to determine the contribution of modulation of potassium and calcium channel function to the vasodilatory effect of sevoflurane in isolated human chorionic plate arterial rings...

Research Grants46

  1. Dynamic contrast-enhanced MRI of placental circulation
    Antonio Frias; Fiscal Year: 2013
    ....
  2. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    ..the AnxAS anticoagulant shield and thereby promote coagulation reactions and reduce blood fluidity in the placental circulation. We have provided strong evidence for this hypothesis and have begun to develop innovative treatments that ..
  3. Initiation and Progression of Preterm Lung Injury with Ventilation
    Alan H Jobe; Fiscal Year: 2013
    ..effects of continued ventilation, we developed a fetal sheep model of newborn resuscitation that maintains placental circulation, thus allowing us to isolate and evaluate resuscitation maneuvers designed to reduce lung injury during ..
  4. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2010
    ..The stress hormone vasopressin is a potent vasoconstrictor in the fetal/placental circulation capable of increasing placental vascular resistance primarily through its receptors, (V1 &V2) which ..
  5. REGULATION OF PLACENTAL VASCULAR REACTIVITY IN PIH
    Leslie Myatt; Fiscal Year: 1991
    ..blood flow but modern imaging techiques have now shown that increased impedance of the fetal- placental circulation and hence reduced blood flow can also be found in PIH...
  6. Impact of Intrauterine Tobacco Smoke Exposure on Umbilical Cord Blood Stem Cells
    JENNIFER KORNOSKY; Fiscal Year: 2009
    ..exposure during pregnancy results in aberrant DNA methylation in hematopoietic stem cells in the feto-placental circulation. This epigenetic response to suboptimal uterine conditions is manifested in offspring as IUGR...
  7. HUMORAL CONTROL OF THE HUMAN PLACENTAL CIRCULATION
    Leslie Myatt; Fiscal Year: 1990
    ..III. The vasoactive effects of naturally occurring epoxy- eicosatrienoic acid metabolites of arachidonic acid in the perfused placenta...
  8. TOBACCO SMOKING, AMINO ACID DISORDERS AND FETAL GROWTH
    RAMA SASTRY; Fiscal Year: 1993
    ..ACh released into the placental circulation stimulates endothelial muscarinic receptors and cause vasodilation...
  9. CARDIOVASCULAR PHENOTYPING IN MICE
    Robert Weiss; Fiscal Year: 2007
    ..the potential for clinical application; 3) determine the nature and magnitude of impairment of maternal-placental circulation in murine disease states which recapitulate important clinical conditions, and develop therapeutic ..
  10. HEMATOPOIETIC CHIMERISM
    DANE BOGGS; Fiscal Year: 1980
    ..Such twins are naturally chimeric for hematopoietic tissue by virtue of common placental circulation. They exhibit no evidence of immunologic incompatibility and thus represent a fairly pure model for ..
  11. Mechanisms of uterine vascular adaptation in pregnancy
    Natalia Gokina; Fiscal Year: 2006
    ..abstract_text> ..
  12. Nutrition, Fetal Growth, and Placental Angiogenesis
    Lawrence P Reynolds; Fiscal Year: 2010
    ..abstract_text> ..
  13. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2008
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  14. THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESIS
    Lawrence Reynolds; Fiscal Year: 2004
    ..abstract_text> ..
  15. ROLE OF NO AND ESTRADIOL IN AGING AND ATHEROGENESIS
    Gautam Chaudhuri; Fiscal Year: 2004
    ..We propose to mimic endothelial dysfunction by pharmacological means by administering animals an inhibitor of NO synthesis. The hypothesis will be tested under three specific aims. ..
  16. AT1 Receptor Activating Autoantibodies and Preeclampsia
    Yang Xia; Fiscal Year: 2008
    ..This hypothesis has the ability to explain many features of this complex life threatening condition and immediately suggests diagnostic and therapeutic opportunities. ..
  17. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  18. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    ..Results from our studies will indicate to us which anti-oxidants are likely to be more effective than others and which can be used clinically to prevent this condition. ..
  19. Adenosine Signaling and Priapsim
    Yang Xia; Fiscal Year: 2008
    ..By understanding the molecular events involved in the development of priapism, we seek to develop novel therapeutic strategies to treat this disease. [unreadable] [unreadable] [unreadable]..
  20. CD1D-Restricted T cells and Pregnancy Loss
    Jonathan E Boyson; Fiscal Year: 2010
    ..Completion of these aims may offer insight into the functional contributions of decidual leukocytes to pathological conditions of pregnancy. ..
  21. Modeling maternal-fetal gene interactions: preterm birth
    Vinod Misra; Fiscal Year: 2008
    ..The educational climate and resources of the University, the commitment of his Department, and the expertise of his mentor will prepare Dr. Misra for a career as an independent investigator. [unreadable] [unreadable]..
  22. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2009
    ..abstract_text> ..
  23. HOW ANTIBODIES WORK--THE FC GAMMA RI MOLECULAR COMPLEX
    CLARK ANDERSON; Fiscal Year: 2001
    ..The experimental approaches of these aims are multidisciplinary and include the methods of immunology, cell biology, molecular genetics, and biochemistry. ..
  24. FcRn Binds and Transports Albumin
    CLARK ANDERSON; Fiscal Year: 2009
    ..abstract_text> ..
  25. DEVELOPMENTAL REGULATION OF O2 SENSING IN THE LUNG
    David Cornfield; Fiscal Year: 2009
    ..The strategy of modulating BKCa channel subunit expression to enhance pulmonary vasodilation may be more broadly applicable to other vascular diseases. ..
  26. Low birth weight, uterine infection, and nitric oxide
    Chandrasekhar Yallampalli; Fiscal Year: 2007
    ..2 will test the hypothesis that NO donor can reverse the increases in DAF expression in uteroplacental and vascular tissues and in fetal growth restriction ..
  27. Adrenomedullin and Human Trophoblast Invasion
    Yuan Lin Dong; Fiscal Year: 2006
    ..Knowledge gained from these studies may assist in designing appropriate therapeutic strategies to prevent preeclampsia in the human. ..
  28. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  29. Control of FcgammaR Triggered Macrophage Function
    CLARK ANDERSON; Fiscal Year: 2002
    ..The significance of this work is that understanding these regulatory mechanisms at the molecular level holds the promise of novel therapeutic approaches for modulating antibody- triggered inflammation and killing. ..
  30. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2002
    ..NO), superoxide and superoxide dismutase (SOD) regulate vascular reactivity and blood flow in the fetal-placental circulation. The rationale is based on evidence that NO is a vasodilator scavenged by superoxide, whereas SOD ..
  31. PREGNANCY AND GI MOTILITY: ROLE OF NITRIC OXIDE
    Gautam Chaudhuri; Fiscal Year: 2002
    ..Aim 4 will assess whether the decrease in motility of the GI tract and delayed gastric emptying during pregnancy can be reversed by inhibition of NO synthesis. ..
  32. Human Biology Association 2002 Annual Meeting
    LORNA MOORE; Fiscal Year: 2002
    ..abstract_text> ..
  33. A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICRO
    Helene Benveniste; Fiscal Year: 2003
    ..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
  34. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  35. ESTRADIOL, NITRIC OXIDE AND CYCLIN D1 IN BREAST CANCER
    Gautam Chaudhuri; Fiscal Year: 2004
    ..abstract_text> ..
  36. How FcRn Prolongs IgG Lifespan
    CLARK ANDERSON; Fiscal Year: 2005
    ..Our technical approaches to the various aims are broad-based and collaborative and include the methods of cellular and molecular biology, biochemistry, and immunology. ..
  37. Estrogen Influences on Fetal Adrenocorticotropin
    Charles Wood; Fiscal Year: 2006
    ..abstract_text> ..
  38. Prenatal Hypoxia and Development of Insulin Resistance
    RUSSELL ANTHONY; Fiscal Year: 2006
    ..These studies will provide insight in to the role fetal hypoxia alone may play in the development of Syndrome X. [unreadable] [unreadable]..
  39. Altitude-induced hypoxia,IUGR and placental function
    Stacy Zamudio; Fiscal Year: 2006
    ..Such work will aid substantially in elucidating the pathologies that involve placenta hypoxia, e.g., preeclampsia, diabetes and IUGR. ..
  40. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2006
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
  41. Doppler characterization of embryonic mouse circulation
    Colin Phoon; Fiscal Year: 2005
    ..abstract_text> ..
  42. A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICRO
    Helene Benveniste; Fiscal Year: 2001
    ..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
  43. REGULATION OF RENIN AND PREECLAMPTIC HYPERTENSION
    Dinesh Shah; Fiscal Year: 2001
    ..These studies will improve our understanding of the role of progesterone in the regulation of reproductive renin and may provide a novel direction for investigating the pathophysiology of preeclampsia. ..
  44. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  45. CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION & GROWTH
    LORNA MOORE; Fiscal Year: 2003
    ..Aim #3 focuses on women residing at either low or high altitude in whom Doppler flow velocimetry and ultrasound imaging will be used to measure uterine artery blood flow. ..