coronary circulation

Summary

Summary: The circulation of blood through the CORONARY VESSELS of the HEART.

Top Publications

  1. ncbi Coronary microembolization: from bedside to bench and back to bedside
    Gerd Heusch
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Essen, Germany
    Circulation 120:1822-36. 2009
  2. ncbi Coronary microvascular dysfunction
    Paolo G Camici
    Medical Research Council Clinical Sciences Centre Hammersmith Hospital, and National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 356:830-40. 2007
  3. ncbi The impact of the coronary collateral circulation on mortality: a meta-analysis
    Pascal Meier
    The Heart Hospital, University College London Hospitals, Cardiology, London, UK
    Eur Heart J 33:614-21. 2012
  4. ncbi Regulation of coronary blood flow during exercise
    Dirk J Duncker
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
    Physiol Rev 88:1009-86. 2008
  5. ncbi Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler echocardiography
    T Hozumi
    Division of Cardiology, Kobe General Hospital, Japan
    Circulation 97:1557-62. 1998
  6. ncbi Myocardial no-reflow in humans
    Giampaolo Niccoli
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    J Am Coll Cardiol 54:281-92. 2009
  7. ncbi Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla
    Jayanth R Arnold
    University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 59:1954-64. 2012
  8. ncbi Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow
    Hasan Turhan
    Inonu University Medical Faculty, Department of Cardiology, Malatya, Turkey
    Int J Cardiol 108:224-30. 2006
  9. pmc The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study
    Edward V R DiBella
    UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, USA
    Int J Cardiovasc Imaging 28:1435-44. 2012
  10. pmc Meta-analysis of the diagnostic performance of stress perfusion cardiovascular magnetic resonance for detection of coronary artery disease
    Michele Hamon
    Department of Radiology, University Hospital of Caen, France
    J Cardiovasc Magn Reson 12:29. 2010

Detail Information

Publications304 found, 100 shown here

  1. ncbi Coronary microembolization: from bedside to bench and back to bedside
    Gerd Heusch
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Essen, Germany
    Circulation 120:1822-36. 2009
    ..Devices for aspiration of thrombi and thrombus-derived vasoconstrictor, thrombogenic, and inflammatory substances, however, reduce thrombus burden, improve perfusion, and provide protection in patients with acute myocardial infarction...
  2. ncbi Coronary microvascular dysfunction
    Paolo G Camici
    Medical Research Council Clinical Sciences Centre Hammersmith Hospital, and National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 356:830-40. 2007
  3. ncbi The impact of the coronary collateral circulation on mortality: a meta-analysis
    Pascal Meier
    The Heart Hospital, University College London Hospitals, Cardiology, London, UK
    Eur Heart J 33:614-21. 2012
    ..The purpose of this systematic review and meta-analysis was to explore the impact of collateral circulation on all-cause mortality...
  4. ncbi Regulation of coronary blood flow during exercise
    Dirk J Duncker
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
    Physiol Rev 88:1009-86. 2008
    ....
  5. ncbi Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler echocardiography
    T Hozumi
    Division of Cardiology, Kobe General Hospital, Japan
    Circulation 97:1557-62. 1998
    ..The purpose of this study was to evaluate the value of CFVR determined by TTDE for the assessment of significant LAD stenosis...
  6. ncbi Myocardial no-reflow in humans
    Giampaolo Niccoli
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    J Am Coll Cardiol 54:281-92. 2009
    ..Thus, in this review article, for the first time, we propose a personalized management of no-reflow on the basis of the assessment of the prevailing mechanisms of no-reflow operating in each patient...
  7. ncbi Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla
    Jayanth R Arnold
    University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 59:1954-64. 2012
    ..The purpose of this study was to assess the diagnostic accuracy of blood oxygen-level dependent (BOLD) MRI in suspected coronary artery disease (CAD)...
  8. ncbi Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow
    Hasan Turhan
    Inonu University Medical Faculty, Department of Cardiology, Malatya, Turkey
    Int J Cardiol 108:224-30. 2006
    ....
  9. pmc The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study
    Edward V R DiBella
    UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, USA
    Int J Cardiovasc Imaging 28:1435-44. 2012
    ..Fixed dose regadenoson and weight adjusted adenosine produce similar measures of MPR in patients with a wide range of body sizes. Regadenoson is a potentially useful vasodilator for stress MRI studies...
  10. pmc Meta-analysis of the diagnostic performance of stress perfusion cardiovascular magnetic resonance for detection of coronary artery disease
    Michele Hamon
    Department of Radiology, University Hospital of Caen, France
    J Cardiovasc Magn Reson 12:29. 2010
    ..Evaluation of the diagnostic accuracy of stress perfusion cardiovascular magnetic resonance for the diagnosis of significant obstructive coronary artery disease (CAD) through meta-analysis of the available data...
  11. ncbi Relationship between regional myocardial oxygenation and perfusion in patients with coronary artery disease: insights from cardiovascular magnetic resonance and positron emission tomography
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
    Circ Cardiovasc Imaging 3:32-40. 2010
    ..Thus, we sought to apply BOLD CMR at 3 T and oxygen-15-labeled water PET in patients with CAD and normal volunteers to better understand the relationship between regional myocardial oxygenation and blood flow during vasodilator stress...
  12. ncbi High-resolution magnetic resonance myocardial perfusion imaging at 3.0-Tesla to detect hemodynamically significant coronary stenoses as determined by fractional flow reserve
    Timothy Lockie
    Cardiovascular Division, King s College London BHF Centre of Excellence, and NIHR Biomedical Research Centre at Guy s and St Thomas NHS Foundation Trust, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    J Am Coll Cardiol 57:70-5. 2011
    ..The objective of this study was to compare visual and quantitative analysis of high spatial resolution cardiac magnetic resonance (CMR) perfusion at 3.0-T against invasively determined fractional flow reserve (FFR)...
  13. ncbi Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study
    Nico H J Pijls
    Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 49:2105-11. 2007
    ..The purpose of this study was to investigate the appropriateness of stenting a functionally nonsignificant stenosis...
  14. ncbi Applications of phase-contrast flow and velocity imaging in cardiovascular MRI
    Peter D Gatehouse
    Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, UK
    Eur Radiol 15:2172-84. 2005
    ..The review includes phase-contrast applications in cardiac function, heart valves, congenital heart diseases, major blood vessels, coronary arteries and myocardial wall velocity...
  15. pmc The coronary circulation in exercise training
    M Harold Laughlin
    Department of Biomedical Sciences, University of Missouri, Columbia, 65211, USA
    Am J Physiol Heart Circ Physiol 302:H10-23. 2012
    ..This suggests that the beneficial effects of EX in CAD may not be the result of direct effects on the coronary artery wall. If this suggestion is true, it is important to determine the mechanisms involved in these beneficial effects...
  16. ncbi Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans
    Hsiao D Lieu
    Portola Pharmaceuticals, South San Francisco, Calif, USA
    J Nucl Cardiol 14:514-20. 2007
    ..This study characterized the dose dependence of regadenoson-induced coronary hyperemia...
  17. ncbi Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging
    Timothy F Christian
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B1D416, MSC 1061, 10 Center Dr, Bethesda, MD 20892 1061, USA
    Radiology 232:677-84. 2004
    ..To compare fluorescent microsphere measurements of myocardial blood flow (MBF) with qualitative, semiquantitative, and fully quantitative measurements of first-pass perfusion at magnetic resonance (MR) imaging...
  18. pmc Quantification of myocardial perfusion by cardiovascular magnetic resonance
    Michael Jerosch-Herold
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Magn Reson 12:57. 2010
    ..Further progress will depend on successful dissemination of the techniques for perfusion quantification among the CMR community...
  19. ncbi Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction
    I Morishima
    Department of Internal Medicine II, Nagoya University School of Medicine, Japan
    J Am Coll Cardiol 36:1202-9. 2000
    ..We sought to elucidate the long-term prognostic importance of angiographic no-reflow phenomenon after percutaneous transluminal coronary angioplasty (PTCA) for acute myocardial infarction (AMI)...
  20. ncbi Coronary flow velocity reserve measurement in three major coronary arteries using transthoracic Doppler echocardiography
    Eriko Murata
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Echocardiography 23:279-86. 2006
    ..The purpose of this study was to evaluate the value of this method in three major coronary arteries for detecting myocardial ischemia in the clinical setting...
  21. ncbi Coronary endothelial vasomotor function and vascular remodeling in heart transplant recipients randomized for tacrolimus or cyclosporine immunosuppression
    Paraskevi Petrakopoulou
    Medizinische Klinik und Poliklinik I, Ludwig Maximilians University of Munich, Munich, Germany
    J Am Coll Cardiol 47:1622-9. 2006
    ..This study aimed to compare changes in coronary endothelial function, systemic endothelin-1 (ET-1) levels, and vascular remodeling in heart transplant recipients randomized to cyclosporin A (CyA) or tacrolimus (Tac) immunosuppression...
  22. ncbi Computation of hemodynamics in the left coronary artery with variable angulations
    Thanapong Chaichana
    Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, G P O Box U1987, Perth, Western Australia 6845, Australia
    J Biomech 44:1869-78. 2011
    ..Further studies based on patients with different severities of coronary artery disease are required to verify our results...
  23. pmc Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 55:2825-32. 2010
    ..We investigated whether coronary microvascular dysfunction predicts major adverse outcomes during follow-up among women with signs and symptoms of ischemia...
  24. pmc A novel porous mechanical framework for modelling the interaction between coronary perfusion and myocardial mechanics
    A N Cookson
    Imaging Sciences and Biomedical Engineering Division, St Thomas Hospital, King s College London, SE1 7EH, UK
    J Biomech 45:850-5. 2012
    ....
  25. ncbi Coronary no reflow
    Bryan G Schwartz
    Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd, Los Angeles, CA 90017, USA
    J Mol Cell Cardiol 52:873-82. 2012
    ..This comprehensive review will cover the underlying mechanisms, methods of assessment, prognostic implications, and potential therapies for the no-reflow phenomenon. This article is part of a Special Issue entitled "Coronary Blood Flow"...
  26. pmc Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles
    Andreas Goette
    Division of Cardiology, University Hospital Magdeburg, Otto von Guericke University, Leipzigerstr 44, 39120 Magdeburg, Germany
    Eur Heart J 30:1411-20. 2009
    ..However, in a large proportion of these patients, significant coronary artery disease is excluded by coronary angiography. Here we explored the potential underlying mechanism of these events...
  27. ncbi Association of TIMI myocardial perfusion grade and ST-segment resolution with cardiovascular magnetic resonance measures of microvascular obstruction and infarct size following ST-segment elevation myocardial infarction
    Evan Appelbaum
    Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Thromb Thrombolysis 27:123-9. 2009
    ..We hypothesized that myocardial perfusion, as assessed by the Thrombolysis in Myocardial Infarction (TIMI) Myocardial Perfusion Grade (TMPG), would be associated with a CMR metric of MO in this population...
  28. ncbi Validation of magnetic resonance myocardial perfusion imaging with fractional flow reserve for the detection of significant coronary heart disease
    Stuart Watkins
    Golden Jubilee National Hospital, Department of Cardiology, Beardmore St, Clydebank, Glasgow, G81 4HX
    Circulation 120:2207-13. 2009
    ..Pressure wire-derived fractional flow reserve (FFR) values <0.75 correlate closely with objective evidence of reversible ischemia. Accordingly, we have compared MRMPI with FFR...
  29. ncbi Effect of erythropoietin as an adjunct to primary percutaneous coronary intervention: a randomised controlled clinical trial
    Andrew J Ludman
    The Hatter Cardiovascular Institute, University College London, London, UK
    Heart 97:1560-5. 2011
    ..We investigated whether high-dose EPO administered as an adjunct to PPCI reduces MI size...
  30. ncbi Patients with syndrome X have normal transmural myocardial perfusion and oxygenation: a 3-T cardiovascular magnetic resonance imaging study
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    Circ Cardiovasc Imaging 5:194-200. 2012
    ....
  31. ncbi Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans
    Shahar Lavi
    Division of Cardiovascular Diseases, Mayo Clinic, Mary Brigh 4 523, First ST SW, Rochester, MN 55905, USA
    Circulation 115:2715-21. 2007
    ..Inflammation also is associated with coronary atherosclerosis. We tested the hypothesis that local coronary production of Lp-PLA2 is enhanced in patients with early coronary atherosclerosis and associated with local endothelial function...
  32. ncbi Direct observation of epicardial coronary capillary hemodynamics during reactive hyperemia and during adenosine administration by intravital video microscopy
    Takahiko Kiyooka
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Am J Physiol Heart Circ Physiol 288:H1437-43. 2005
    ....
  33. ncbi Heart rate reduction during exercise-induced myocardial ischaemia and stunning
    Xavier Monnet
    Laboratoire de Pharmacologie, INSERM E 00 01, Faculte de Medecine Paris Sud, Paris, France
    Eur Heart J 25:579-86. 2004
    ..The effects of selective heart rate reduction by ivabradine (If inhibitor) were compared to those of atenolol on exercise-induced ischaemia and stunning...
  34. ncbi No-reflow phenomenon
    Shereif H Rezkalla
    Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin, USA
    Circulation 105:656-62. 2002
  35. ncbi Vascular endothelial function in patients with slow coronary flow
    Alpay Turan Sezgin
    Department of Cardiology, Inonu University, Malatya, Turkey
    Coron Artery Dis 14:155-61. 2003
    ..Slow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear...
  36. ncbi Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  37. ncbi Comparative profile of vasodilation by CVT-3146, a novel A2A receptor agonist, and adenosine in conscious dogs
    Gong Zhao
    CV Therapeutics, Inc, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 307:182-9. 2003
    ..Furthermore, CVT-3146 did not cause renal vasoconstriction. These features make CVT-3146 a better candidate for pharmacologic stress testing...
  38. ncbi Selective A2A adenosine receptor agonist as a coronary vasodilator in conscious dogs: potential for use in myocardial perfusion imaging
    Jean Noel Trochu
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    J Cardiovasc Pharmacol 41:132-9. 2003
    ....
  39. ncbi Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology
    Morton J Kern
    University of California, Irvine, USA
    Circulation 114:1321-41. 2006
    ..The goal of this statement is to provide a logical approach to the use of coronary physiological measurements in the catheterization lab to assist both clinicians and investigators in improving patient care...
  40. ncbi Prevention and treatment of microvascular obstruction-related myocardial injury and coronary no-reflow following percutaneous coronary intervention: a systematic approach
    Ronen Jaffe
    Lady Davis Medical Center, Department of Cardiology, Haifa, Israel
    JACC Cardiovasc Interv 3:695-704. 2010
    ..New approaches for prevention and treatment of MVO will require a better understanding of intracellular cardioprotective pathways such as the blockade of the mitochondrial permeability transition pore...
  41. ncbi No-reflow phenomenon: maintaining vascular integrity
    Robert A Kloner
    Heart Institute, Good Samaritan Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90017, USA
    J Cardiovasc Pharmacol Ther 16:244-50. 2011
    ....
  42. pmc Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction
    Colin Berry
    Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:527-35. 2010
    ..The area at risk (AAR) is a key determinant of myocardial infarction (MI) size. We investigated whether magnetic resonance imaging (MRI) measurement of AAR would be correlated with an angiographic AAR risk score in patients with acute MI...
  43. ncbi Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation
    Pim A L Tonino
    Department of Cardiology, Catharina Hospital, Michelangelolaan 2, Eindhoven 5623 EJ, The Netherlands
    J Am Coll Cardiol 55:2816-21. 2010
    ..The purpose of this study was to investigate the relationship between angiographic and functional severity of coronary artery stenoses in the FAME (Fractional Flow Reserve Versus Angiography in Multivessel Evaluation) study...
  44. ncbi Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique
    T Hozumi
    Division of Cardiology, Kobe General Hospital, Japan
    J Am Coll Cardiol 32:1251-9. 1998
    ....
  45. ncbi Isolated heart perfusion according to Langendorff---still viable in the new millennium
    Monika Skrzypiec-Spring
    Department of Pharmacology, Medical University Wroclaw, Wroclaw, Poland
    J Pharmacol Toxicol Methods 55:113-26. 2007
    ..from blood via the coronary arteries and that cardiac mechanical function is reflected by changes in the coronary circulation. The method underwent many modifications but its general principle remains the same today...
  46. ncbi Validation of a one-dimensional model of the systemic arterial tree
    Philippe Reymond
    Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 297:H208-22. 2009
    ..The study constitutes a first validation of the complete 1-D model using human pressure and flow data and supports the applicability of the 1-D model in the human circulation...
  47. ncbi Regadenoson induces comparable left ventricular perfusion defects as adenosine: a quantitative analysis from the ADVANCE MPI 2 trial
    John J Mahmarian
    Methodist DeBakey Heart and Vascular Center, Houston, Texas 77030, USA
    JACC Cardiovasc Imaging 2:959-68. 2009
    ..This study sought to determine whether regadenoson induces left ventricular perfusion defects of similar size and severity as seen with adenosine stress...
  48. ncbi Cardiovascular flow measurement with phase-contrast MR imaging: basic facts and implementation
    Joachim Lotz
    Department of Diagnostic Radiology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Radiographics 22:651-71. 2002
    ..With phase-contrast imaging, the overall error in flow measurement can be reduced to less than 10%, an acceptable level of error for routine clinical use...
  49. ncbi Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles
    Cuihua Zhang
    Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, College Station, Tex, USA
    Hypertension 44:935-43. 2004
    ..The inability of arginase blockade or l-arginine supplementation to completely restore vasodilation may be related to downregulation of endothelial NOS expression...
  50. ncbi Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, California 90017 2395, USA
    Am J Physiol Heart Circ Physiol 283:H1099-107. 2002
    ..06 +/- 0.01 ml x min(-1) x g(-1)). The development of macroscopic hemorrhage lagged behind no reflow, was closely correlated with it, and may be the consequence of microvascular damage...
  51. ncbi Prognostic value of coronary vascular endothelial dysfunction
    Julian P J Halcox
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circulation 106:653-8. 2002
    ....
  52. ncbi Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: a randomized trial
    G J Bech
    Catharina Hospital, Eindhoven, The Netherlands
    Circulation 103:2928-34. 2001
    ..CONCLUSIONS: In patients with a coronary stenosis without evidence of ischemia, coronary pressure-derived FFR identifies those who will benefit from PTCA...
  53. ncbi Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both?
    Amir Lerman
    Division of Cardiovascular Disease, Department of Internal Medicine, Mayo Clinic and College of Medicine, 200 First Street SW, Rochester, MN 55902, USA
    Eur Heart J 28:788-97. 2007
    ..In the current work, we aimed at reviewing the role of the coronary microcirculation in the development and outcome of this acute coronary syndrome entity...
  54. ncbi Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?
    Kerstin Wustmann
    Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Circulation 107:2213-20. 2003
    ..Such preformed coronary collateral vessels could form the basis for subsequently developing protective natural bypasses in the presence of coronary artery disease...
  55. ncbi Noninvasive quantification of left-to-right shunt in pediatric patients: phase-contrast cine magnetic resonance imaging compared with invasive oximetry
    P Beerbaum
    Clinic for Congenital Heart Disease, Heart and Diabetes Center, North Rhine Westfalia, Ruhr University Bochum, Germany
    Circulation 103:2476-82. 2001
    ..Blood flow can be quantified noninvasively by phase-contrast cine MRI (PC-MRI) in adults. Little is known about the feasibility of the method in children with congenital heart disease...
  56. ncbi Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study
    Peter H Stone
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:438-44. 2003
    ..The endothelium controls local arterial responses by transduction of shear stress. Characterization of endothelial shear stress (ESS) may allow for prediction of progression of atherosclerosis and in-stent restenosis...
  57. pmc Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Exp Med 197:615-24. 2003
    ..These data offer a mechanistic link between inflammation and LV remodeling by demonstrating a heretofore unrecognized role for MPO and PAI-1 in orchestrating the myocardial response to AMI...
  58. ncbi Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka, Japan
    J Nucl Med 46:1219-24. 2005
    ..The basis function method linearizes the solution of the 1-tissue-compartment model, which results in a computationally much faster method than the conventional nonlinear least-squares fitting method in estimating the parameters...
  59. ncbi The extent of microvascular damage during myocardial contrast echocardiography is superior to other known indexes of post-infarct reperfusion in predicting left ventricular remodeling: results of the multicenter AMICI study
    Leonarda Galiuto
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    J Am Coll Cardiol 51:552-9. 2008
    ....
  60. ncbi Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    Alexandre Berger
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:438-42. 2005
    ....
  61. ncbi Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease
    J T Kuvin
    Department of Medicine/Division of Cardiology, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 38:1843-9. 2001
    ..Further standardization of BAUS is required, however, before specific cut-points for excluding CAD can be established...
  62. ncbi Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study
    Shmuel Fuchs
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, 110 Irving Street NW, 4B 1, Washington, DC 20010, USA
    J Am Coll Cardiol 41:1721-4. 2003
    ..We conducted a pilot study to evaluate the feasibility of transendocardial delivery of autologous bone marrow (ABM) strategy in patients with severe symptomatic chronic myocardial ischemia not amenable to conventional revascularization...
  63. ncbi Coronary hemodynamic regulation by nitric oxide in experimental animals: recent advances
    Noboru Toda
    Toyama Institute for Cardiovascular Pharmacology Research 7 13, 1 chome, Azuchi machi, Chuo Ku, Osaka 541 0052, Japan
    Eur J Pharmacol 667:41-9. 2011
    ....
  64. ncbi Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow
    Habil Yucel
    Department of Cardiology, State Hospital, Isparta, Turkey
    Scand J Clin Lab Invest 72:495-500. 2012
    ..ADMA levels may be increased by homocysteine. The aim of this study was to evaluate the relationship between ADMA, nitric oxide and homocysteine in patients with SCF...
  65. ncbi Detection and quantification of myocardial reperfusion hemorrhage using T2*-weighted CMR
    Andreas Kumar
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    JACC Cardiovasc Imaging 4:1274-83. 2011
    ....
  66. ncbi Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus
    John O Prior
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 6948, USA
    Circulation 111:2291-8. 2005
    ....
  67. ncbi Elevated red cell distribution width level predicts worse postinterventional thrombolysis in myocardial infarction flow reflecting abnormal reperfusion in acute myocardial infarction treated with a primary coronary intervention
    Ahmet Karabulut
    Department of Cardiology, Istanbul Medicine Hospital, Istanbul, Turkey
    Coron Artery Dis 23:68-72. 2012
    ..Herein, we aimed to demonstrate the impact of an elevated RDW level on the postinterventional thrombolysis in myocardial infarction (TIMI) flow in AMI patients...
  68. ncbi Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiological severity
    Nils P Johnson
    Weatherhead PET Center for Preventing and Reversing Atherosclerosis, Division of Cardiology, Department of Medicine, University of Texas Medical School and Memorial Hermann Hospital, Houston, Texas 77030, USA
    JACC Cardiovasc Imaging 5:430-40. 2012
    ..Our standardized framework could prompt future studies leading to a trial of revascularization guided by absolute flow measurements...
  69. doi Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention
    Ronen Jaffe
    Schulich Heart Programme, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Suite A 253, Toronto, Ontario, Canada
    Circulation 117:3152-6. 2008
  70. ncbi Artifacts from misaligned CT in cardiac perfusion PET/CT studies: frequency, effects, and potential solutions
    Axel Martínez-Möller
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Munich, Germany
    J Nucl Med 48:188-93. 2007
    ..The purpose of this work was to assess the clinical impact of emission-transmission misalignment in myocardial perfusion imaging with PET/CT and to investigate potential solutions...
  71. ncbi The effects of homocysteine-related compounds on cardiac contractility, coronary flow, and oxidative stress markers in isolated rat heart
    Vladimir Zivkovic
    Department of Physiology, Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia
    Mol Cell Biochem 370:59-67. 2012
    ..L-Hcy TLHC showed a cardiotoxic effect by affecting heart contractility, but surprisingly, it decreased the release of O(2)(-)...
  72. ncbi Impaired coronary flow reserve as a marker of microvascular dysfunction to predict long-term cardiovascular outcomes, acute coronary syndrome and the development of heart failure
    Koki Nakanishi
    Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Circ J 76:1958-64. 2012
    ..This study aimed to assess the prognostic value of TTDE-derived CFR (as a marker of microvascular function) in predicting long-term cardiovascular events, acute coronary syndrome (ACS) events, and the development of heart failure (HF)...
  73. ncbi Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy
    Franco Cecchi
    Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy
    N Engl J Med 349:1027-35. 2003
    ..We prospectively evaluated a cohort of patients with hypertrophic cardiomyopathy after they had undergone quantitative assessment of myocardial blood flow by positron-emission tomography (PET)...
  74. ncbi In vivo micro particle image velocimetry measurements of blood-plasma in the embryonic avian heart
    Peter Vennemann
    Laboratory for Aero and Hydrodynamics, Delft University of Technology, Leeghwaterstraat 21, 2628 CA Delft, The Netherlands
    J Biomech 39:1191-200. 2006
    ..In general, the measurements demonstrate that muPIV has the potential to develop into a general tool for instationary flow conditions in complex flow geometries encountered in cardiovascular research...
  75. ncbi Neural control hierarchy of the heart has not evolved to deal with myocardial ischemia
    G Kember
    Department of Engineering Mathematics, Dalhousie University, Halifax, Nova Scotia, Canada
    Physiol Genomics 45:638-44. 2013
    ..On the basis of these results it is proposed that under the singular conditions of myocardial ischemia a determination of neural control indexes in addition to cardiovascular indexes has the potential of enhancing clinical outcome...
  76. ncbi Role of potassium channels in coronary vasodilation
    Gregory M Dick
    Department of Exercise Physiology and Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Exp Biol Med (Maywood) 235:10-22. 2010
    ..The purpose of this article is to review the types of K(+) channels expressed in CASMC, discuss the regulation of their activity by physiological mechanisms and examine impairments related to cardiovascular disease...
  77. pmc Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation
    Matthias Vöhringer
    Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada
    J Cardiovasc Magn Reson 12:20. 2010
    ....
  78. pmc Long-term administration of endothelin receptor antagonist improves coronary endothelial function in patients with early atherosclerosis
    Martin Reriani
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    Circulation 122:958-66. 2010
    ..The present study was designed to test the hypothesis that long-term treatment with an endothelin-A (ET(A)) receptor antagonist improves coronary endothelial function in patients with early coronary atherosclerosis...
  79. pmc Theoretical models for coronary vascular biomechanics: progress & challenges
    Sarah L Waters
    Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, 24 29 St Giles, Oxford, OX1 3LB, UK
    Prog Biophys Mol Biol 104:49-76. 2011
    ....
  80. ncbi Value of cardiovascular magnetic resonance stress perfusion testing for the detection of coronary artery disease in women
    Igor Klem
    Duke Cardiovascular Magnetic Resonance Center, Durham, North Carolina 27710, USA
    JACC Cardiovasc Imaging 1:436-45. 2008
    ..We wanted to assess the value of cardiovascular magnetic resonance (CMR) stress testing for evaluation of women with suspected coronary artery disease (CAD)...
  81. ncbi Regional blood flow analysis and its relationship with arterial branch lengths and lumen volume in the coronary arterial tree
    Sabee Molloi
    Department of Radiological Sciences, University of California, Irvine, CA 92697, USA
    Phys Med Biol 52:1495-503. 2007
    ..This theoretical maximum blood flow, in conjunction with an angiographically measured blood flow, can potentially be used to calculate fractional flow reserve based entirely on angiographic data...
  82. pmc Feasibility and safety of high-dose adenosine perfusion cardiovascular magnetic resonance
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 12:66. 2010
    ..The aim of the present study was to assess the tolerance and safety of a high-dose adenosine protocol in patients with inadequate haemodynamic response to the standard adenosine protocol when undergoing CMR perfusion imaging...
  83. ncbi Plasma nitric oxide level and its role in slow coronary flow phenomenon
    Nurzen Sezgin
    Biochemical Department, Baskent University Practice and Research Hospital, Adana, Turkey
    Int Heart J 46:373-82. 2005
    ..Also, the plasma NO level was inversely correlated with TFC for each artery. Reduced NO bioactivity as well as impaired FMD support the presence of endothelial damage in the pathogenesis of SCF phenomenon...
  84. ncbi Clinical feasibility of accelerated, high spatial resolution myocardial perfusion imaging
    Robert Manka
    Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
    JACC Cardiovasc Imaging 3:710-7. 2010
    ....
  85. ncbi Coronary no-reflow phenomenon: from the experimental laboratory to the cardiac catheterization laboratory
    Shereif H Rezkalla
    Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin 54449, USA
    Catheter Cardiovasc Interv 72:950-7. 2008
    ..Distal intracoronary injection of verapamil, nicardipine, adenosine, and nitroprusside may improve coronary flow in the majority of patients. Hemodynamic support of the patient may be needed in some cases until coronary flow improves...
  86. ncbi T grafts with the right internal thoracic artery to left internal thoracic artery versus the left internal thoracic artery and radial artery: flow dynamics in the internal thoracic artery main stem
    O Wendler
    Department of Thoracic and Cardiovascular Surgery, University Hospital Homburg Saar, Germany
    J Thorac Cardiovasc Surg 118:841-8. 1999
    ..There is still uncertainty whether the coronary flow reserve in the main stem of the left internal thoracic artery is sufficient to supply more than 1 anastomosed coronary vessel...
  87. pmc Mild hypothermia to limit myocardial ischemia-reperfusion injury: importance of timing
    Shinya Kanemoto
    Harrison Department of Surgical Research, Glenolden Research Laboratory, University of Pennsylvania, Glenolden, Pennsylvania 19036, USA
    Ann Thorac Surg 87:157-63. 2009
    ..5 degrees C) and to determine whether the application of hypothermia at different points during the ischemia-reperfusion period influenced the degree of myocardial salvage...
  88. ncbi Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention
    Michael C H Leung
    Cardiovascular Research Centre, Monash Medical Centre and Monash Univ, Melbourne, Victoria, Australia
    Am J Physiol Heart Circ Physiol 290:H624-30. 2006
    ..025) were less marked in a stiff aorta than a compliant aorta. A stiff aorta is associated with a reduction in CBF, a lower hyperemic CBF response, and may reduce the improvement in hyperemic CBF after successful PCI...
  89. ncbi Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging integrated ADVANCE-MPI trial results
    Manuel D Cerqueira
    Departments of Nuclear Medicine and Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    JACC Cardiovasc Imaging 1:307-16. 2008
    ....
  90. pmc Scaling of myocardial mass to flow and morphometry of coronary arteries
    Jenny Susana Choy
    Indiana University Purdue University, 635 Barnhill Drive, MS 2069, Indianapolis, IN 46202, USA
    J Appl Physiol (1985) 104:1281-6. 2008
    ..These scaling laws suggest fundamental design principles underlying the structure-function relationship of the coronary arterial tree that may facilitate diagnosis and management of diffuse coronary artery disease...
  91. ncbi Development of motion correction technique for cardiac (15)O-water PET study using an optical motion tracking system
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 24:1-11. 2010
    ..We developed a motion correction system using an optical motion-tracking device to detect a subject's global movement for cardiac study...
  92. ncbi Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation
    Duncan J Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    J Hypertens 22:1971-6. 2004
    To investigate the role of angiotensin-converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation.
  93. ncbi Effect of coronary collaterals on microvascular obstruction as assessed by magnetic resonance imaging in patients with acute ST-elevation myocardial infarction treated by primary coronary intervention
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am J Cardiol 104:1204-9. 2009
    ..5% vs 12.2%, p = 0.07). In conclusion, well-developed collaterals before reperfusion by PCI in patients with STEMI are associated with a protective effect on coronary microcirculation...
  94. ncbi Lessons from human coronary aspirate
    Petra Kleinbongard
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    J Mol Cell Cardiol 52:890-6. 2012
    ..This article is part of a Special Issue entitled "Coronary Blood Flow."..
  95. ncbi Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik 1, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Am J Physiol Heart Circ Physiol 290:H2516-21. 2006
    ..The myocardium in CK-deficient mice is characterized by reduced perfusion and reduced maximal contraction velocity, suggesting that the myocardial hypertrophy seen in these mice cannot fully compensate for the absence of the CK system...
  96. ncbi A hybrid one-dimensional/Womersley model of pulsatile blood flow in the entire coronary arterial tree
    Yunlong Huo
    Department of Biomedical Engineering, Indiana Univeristy Purdue Univeristy Indianapolis, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 292:H2623-33. 2007
    ..The present model has numerous applications to understanding the dynamics of coronary circulation.
  97. ncbi Rubidium-82 PET-CT for quantitative assessment of myocardial blood flow: validation in a canine model of coronary artery stenosis
    Riikka Lautamaki
    Department of Radiology, Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21210, USA
    Eur J Nucl Med Mol Imaging 36:576-86. 2009
    ..The aim of this study was to reevaluate the feasibility of (82)Rb for flow quantification, using hybrid PET-CT in an animal model of coronary stenosis...
  98. ncbi C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes
    Lavinia Forte
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Italy
    Int J Cardiol 152:7-12. 2011
    ..Thus, the aim of this study was to determine whether CRP is produced in the culprit lesion and released within the coronary circulation of patients with ACS and whether it may affect coronary endothelial function.
  99. ncbi Impact of unexpected factors on quantitative myocardial perfusion and coronary flow reserve in young, asymptomatic volunteers
    Stefano Sdringola
    Department of Medicine, University of Texas Medical School, Houston, TX, USA
    JACC Cardiovasc Imaging 4:402-12. 2011
    ..We sought to quantify ranges of normal myocardial perfusion and flow reserve in young, asymptomatic volunteers after systematic historical and laboratory screening for unexpected factors affecting coronary flow...
  100. ncbi The human coronary collateral circulation
    Christian Seiler
    Cardiology, University Hospital, Bern, Switzerland
    Eur J Clin Invest 40:465-76. 2010
    ..Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) mitigate myocardial infarcts and improve survival...
  101. ncbi Augmentation of tissue perfusion by a novel compression device increases neurologically intact survival in a porcine model of prolonged cardiac arrest
    Fumiaki Ikeno
    Division of Cardiovascular Medicine, Stanford University, Palo Alto, CA, USA
    Resuscitation 68:109-18. 2006
    ..This study was performed to determine the potential efficacy of an automated device with a load-distributing band (AutoPulse, Revivant Corporation), in improving neurologically intact survival after cardiac arrest...

Research Grants64

  1. FETAL HYPOXEMIA AND ENDOTHELIUM DERIVED NITRIC OXIDE
    Loren P Thompson; Fiscal Year: 2010
    ..upregulates the NOS pathway in fetal hearts inducing cardioprotection by increasing eNOS-derived NO in the coronary circulation and cardiac injury by iNOS-derived NO in the cardiomyocytes of the ventricle...
  2. Coronary Vasculature Progenitor Cell in Human Ischemic Heart Failure
    Annarosa Leri; Fiscal Year: 2012
    ..The hypothesis to be tested is that vascular niches are present within the wall of the coronary circulation and vascular progenitor cells (VPCs) are stored within vascular niches...
  3. CT Method Development for Quantifying Myocardial Microvascular Flow Distribution
    ERIK LEO RITMAN; Fiscal Year: 2013
    ..Image Data - Ia: Using pigs, generate an MSCT image sequence while the contrast bolus passes through the coronary circulation. Then, repeat this procedure while the LAD coronary artery is infused with adenosine...
  4. Metabolic Syndrome, Inflammation and Vascular Remodeling
    Francine K Welty; Fiscal Year: 2012
    ..technique, multidetector computed tomographic angiography (MDCTA) that examines dynamic processes in the coronary circulation, including the development and regression of soft and hard plaques...
  5. Research Centers in Minority Institutions Clinical Rese*
    Eve Higginbotham; Fiscal Year: 2009
    ..in endothelial function that predispose to vasoconstriction and structural microvessel occlusion within the coronary circulation. Setting in motion a cascade of pathobiological processes that predispose to myocardial ischemia, recurrent ..
  6. Role of Endothelial Progenitor Cells in vascular Aging and Calcification
    Amir Lerman; Fiscal Year: 2013
    ..of intravascular ultrasound [IVUS]) (Aim 3a), and that these osteogenic EPCs are being consumed by the coronary circulation (Aim 3b). The proposed studies thus test novel hypotheses using a multidisciplinary approach...
  7. Coronary Physiology
    Eric O Feigl; Fiscal Year: 2010
    ..A new hypothesis, with supporting data, is presented where ATP released from red blood cells in the coronary circulation acts as a mediator of local metabolic coronary vasodilation...
  8. Lp-PLA2 and Coronary Atherosclerosis in Humans
    Amir Lerman; Fiscal Year: 2013
    ..vascular wall properties, and the systemic as well as the coronary activity of the Lp-PLA2 pathway, in the coronary circulation. To address our working hypothesis, three Specific Aims are proposed...
  9. Mechanism of the coronary heart disease association at chromosome 6q23.2
    Thomas Quertermous; Fiscal Year: 2013
    ..first cloned in this and two other laboratories and shown to mark progenitor cells that give rise to the coronary circulation. Targeted deletion of Tcf21 has been associated with disrupted vascular smooth muscle cell (SMC) ..
  10. Mechanisms of Coronary Ostium Formation and Coronary Artery Patterning
    Bin Zhou; Fiscal Year: 2013
    ..The coronary circulation starts when the passive diffusion of oxygen and nutrients is no longer sufficient for the heart growth and ..
  11. Rebuilding the Failing Heart
    Piero Anversa; Fiscal Year: 2013
    ..and endothelial cells would suggest that the heart has the ability to create the various portions of the coronary circulation, from conductive coronary arteries to capillary structures...
  12. Translational studies in Heart Failure Gene Therapy
    Charles R Bridges; Fiscal Year: 2013
    ..that uniquely allows for in situ, multiple-pass recirculation of recombinant vector in the isolated coronary circulation in large animals...
  13. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..have shown that capillaries are responsible for limiting the maximal hyperemic response seen in the normal coronary circulation and that capillary blood volume decreases distal to a stenosis during hyperemia...
  14. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..have shown that capillaries are responsible for limiting the maximal hyperemic response seen in the normal coronary circulation and that capillary blood volume decreases distal to a stenosis during hyperemia...
  15. DEVELOPING CELLULAR CARDIOMYOPLASTY FOR INJURED HEART
    DORIS TAYLOR; Fiscal Year: 2001
    ..to rabbit heart: localized delivery via direct injection or more dispersed delivery via infusion onto the coronary circulation; 3) use load-insensitive in dices of regional cardiac function to determine the temporal effects of ..
  16. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    ..NO in the control of oxygen and substrate use during pregnancy with particular reference to the heart and coronary circulation. In the first specific aim, we will examine the role of NO in the control or metabolism in aged eNOS KO ..
  17. Implantable construct for architectural control of re-vascularization of ischemic
    Michael Yang; Fiscal Year: 2013
    ..Despite substantial progress in angioplasty and bypass surgery to rescue perfusion to the coronary circulation, ischemic heart disease remains the leading cause of mortality and morbidity...
  18. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..Ischemia is caused by an imbalance in the heart's consumption of oxygen and the delivery of oxygen by the coronary circulation. Under normal conditions, the heart avoids ischemia by tightly matching myocardial oxygen consumption to ..
  19. FEEDFORWARD CONTROL OF CORONARY BLOOD FLOW
    ERIC FEIGL; Fiscal Year: 1999
    ..result in tachycardia, increases in myocardial contractility and beta-adrenergic vasodilation of the coronary circulation. The applicant postulates that beta-mediated coronary vasodilation is a form of feedforward or parallel ..
  20. INTEGRATIVE APPROACH TO CORONARY THROMBOSIS
    Robert Montgomery; Fiscal Year: 2001
    ..of a coronary artery following thrombolytic therapy, form a spectrum of thrombotic related diseases in the coronary circulation. The role of platelets in these syndromes has been the subject of major therapeutic advances in recent ..
  21. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..MIF released from the lung passes directly into the coronary circulation where it interacts with the cardiac myocytes causing cardiac dysfunction...
  22. DIGITAL ANGIOGRAPHIC ANALYSIS OF MYOCARDIAL PERFUSION
    Neal Eigler; Fiscal Year: 1992
    ..The long range purpose of this grant is to solve these problems by modeling the coronary circulation as a linear system. To evaluate this possibility we have established five goals: 1...
  23. CORONARY ARTERY BYPASS ENDARTERECTOMY STAGING TRIAL
    John Ricotta; Fiscal Year: 2002
    ..When patients have surgical lesions in both carotid and coronary circulation, management alternatives include performing either the carotid endarterectomy (CEA) or the CABG first, ..
  24. EFFECTS OF HYPERTROPHY ON THE CORONARY CIRCULATION
    Kevin Dellsperger; Fiscal Year: 1991
    ..it is now generally held that many types of cardiac hypertrophy significantly and adversely alter the coronary circulation and the electrophysiological characteristics of hypertrophied cardiac muscle, many important areas remain ..
  25. Flow-Mediated Dilation of Human Coronary Arterioles
    David D Gutterman; Fiscal Year: 2010
    ..A bioassay system will confirm whether H2O2 is indeed an EDHF mediating FMD in the human coronary circulation. Second we will use immunohistochemistry and specific pharmacological and molecular approaches including ..
  26. Myocardial Gene Transfer during Cardiac Surgery in Swine
    Carmelo Milano; Fiscal Year: 2006
    ..These steps may facilitate safer gene delivery since they result in an interruption of the coronary Circulation and an isolation of the coronary circulation from the systemic circulation, making "cardioselective" gene ..
  27. PHARMACOLOGY OF ISCHEMIC MYOCARDIUM
    David Warltier; Fiscal Year: 1991
    ..agents influence the distribution of coronary blood flow across the left ventricular wall in the normal coronary circulation and in the coronary circulation with various degrees of coronary artery stensosis or total coronary artery ..
  28. CORONARY MICROVASCULAR RESPONSES TO HUMORAL SUBSTANCES
    Kathryn Lamping; Fiscal Year: 1991
    ..does 5-hydroxytryptamine alter microvascular dynamics (pressure and diameter) in different segments of the coronary circulation? What are the mechanisms involved in these differential responses? 2) Is the distribution of microvascular ..
  29. CARDIOVASCULAR ADAPTATIONS TO RENOVASCULAR HYPERTENSION
    PATRICIA GWIRTZ; Fiscal Year: 2001
    ..tested is that renovascular hypertension alters the neural, paracrine and autocrine control systems of the coronary circulation through exacerbation of vasoconstrictor inputs and attenuation of vasodilator influences...
  30. OPIATE/AUTONOMIC INTERACTIONS IN THE CIRCULATORY SYSTEM
    JAMES CAFFREY; Fiscal Year: 1991
    ..My objective is to define clearly this opiate/adrenergic interaction as it applies to the heart and coronary circulation. An isolated heart/lung model is necessary to focus on the heart and to control complicating CNS and ..
  31. ADENOSINE & KATP CHANNEL CONTROL OF CORONARY BLOOD FLOW
    ERIC FEIGL; Fiscal Year: 2005
    ..A new hypothesis, with supporting data, is presented where ATP released from red blood cells in the coronary circulation acts as the mediator of local metabolic coronary vasodilation...
  32. TISSUE ENGINEERED VASCULAR PROSTHESES
    Laura Niklason; Fiscal Year: 2000
    ..Internal mammary arteries, which perform better than vein grafts, are useful only in the coronary circulation. To address these issues, the long term goal of this project is to develop a method for culturing ..
  33. RADIOGRAPHIC CONTRAST TOXICITY IN THE ISCHEMIC HEART
    ANN ALS; Fiscal Year: 1980
    ..An animal model, in which a part of the coronary circulation is separately perfused with oxygenated blood, will be used to examine the time course of changes in the ..
  34. Plasmalogen Metabolism by iPLA2 in Ischemic Myocardium
    Jane McHowat; Fiscal Year: 2005
    ..These studies will provide important information regarding how arrhythmogenic substances in the coronary circulation may gain access to ischemic cardiac myocytes, the biochemical pathways involved in iPLA2 activation and the ..
  35. PRAISE Study
    Marc Chimowitz; Fiscal Year: 2005
    ..The success of drug-eluting stents in the coronary circulation for preventing restenosis raises the possibility that these stents may also be effective in the cerebral ..
  36. BLOOD FLOW, CONTRACTILE AND METABOLIC FUNCTION IN LVH
    VICTOR DAVILA ROMAN; Fiscal Year: 2001
    ..and elucidating whether reversal of LVH with antihypertensive medication results in salutary effects to the coronary circulation and cardiac function and whether it is associated with reduced morbidity and mortality from cardiovascular ..
  37. CONFERENCE ON SUBSTANCE P & RELATED PEPTIDES
    Susan Leeman; Fiscal Year: 1990
    ..Substance P fibers innervate the vasculature including the coronary circulation. Thus the possible clinical implications of substance P will be considered...
  38. A CONTROLLED TRIAL TO REVERSE CORONARY ATHEROSCLEROSIS
    Frank Sacks; Fiscal Year: 1991
    ..Therefore, the effect of therapy will be determined in native coronary arteries that are in a native coronary circulation and that are in a circulation that has received aortocoronary bypass grafts...
  39. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..MR model, and (3) to evaluate long-term effects of mitral annular remodeling on MR, tissue reaction, coronary circulation, and LV function by comparison with a tachycardia-induced MR Control group...
  40. INTERVENTIONS TO IMPROVE CARDIAC FUNCTION IN ISCHEMIA
    Carl Jones; Fiscal Year: 1980
    ..Presently, studies are proposed to study the effects of hypoxanthine, a related purine, on the heart and coronary circulation. Also, studies are proposed to determine whether inosine has a direct vasodilating action on the coronary ..
  41. CORONARY REACTIVITY AND OXIDATIVE STRESS
    Joseph Vita; Fiscal Year: 1999
    DESCRIPTION: This is a resubmitted grant application to study endothelium- dependent relaxation in the coronary circulation of patients with coronary atherosclerosis...
  42. CARDIOVASCULAR CONTROL IN NORMAL AND DISEASE STATES
    STEPHEN VATNER; Fiscal Year: 2001
    ..Secondly efferent autonomic control of ventricular performance, the coronary circulation, and the regional circulations will be studied. Thirdly, autonomic control during exercise will be examined...
  43. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..permeabilizing agents with retrograde re-circulation of recombinant adeno associated virus (rAAV) in the coronary circulation. This technique is predicted to result in a dramatic increase in the transendothelial delivery of rAAV into ..
  44. 26th Annual Meeting of the North Am. Section of the ISHR
    Francisco Villarreal; Fiscal Year: 2004
    ..in cardiovascular disease, new insights into nonischemic cardiomyopathies, myocardial depressant factor, coronary circulation and ischemia, receptor function and signaling, angiogenesis, inflammation, atherosclerosis, preconditioning,..
  45. Gene Therapy for Vaso-occlusive Disorders
    Stephen Russell; Fiscal Year: 2005
    ..employ a novel vascular stent seeded with genetically modified smooth muscle cells to deliver VEGF into the coronary circulation to induce angiogenesis in a porcine model of chronic total coronary occlusion...
  46. EFFECTS OF HYPERTENSION ON THE CORONARY CIRCULATION
    Kevin Dellsperger; Fiscal Year: 1993
    ....
  47. Myocardial Gene Transfer During Simulated Heart Surgery
    Jacob Schroder; Fiscal Year: 2004
    ..surgery may facilitate safer gene delivery since they result in an interruption and isolation of the coronary circulation. The central hypothesis is that global myocardial transgene expression can be safely achieved in adult ..
  48. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  49. POSITRON TOMOGRAPHY IN ISCHEMIC HEART DISEASE
    Heinrich Schelbert; Fiscal Year: 2004
    ....
  50. ANGIOGENIC THERAPY FOR INFARCTED AND ISCHEMIC HEART
    Robert Tomanek; Fiscal Year: 2003
    ..Such interventions have a number of advantages over more invasive interventions, e.g., the delivery of oxogenous growth factors or gene therapy. ..
  51. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2003
    ..as a natural extension of the principal investigator's previous KO-8, which focused on endothelin in the coronary circulation in humans...
  52. Coronary Endothelial Function in Humans
    Amir Lerman; Fiscal Year: 2006
    ..scientific aims of this application are: 1) to determine the role of endothelial humoral regulation of the coronary circulation with a specific focus upon endothelin and oxidative stress in early coronary atherosclerosis and ..
  53. Regulation of Coronary Vessel Assembly and Growth
    Robert Tomanek; Fiscal Year: 2007
    ..Since cardiac development depends on timely and adequate vascularization, an understanding of coronary vasculogenesis and angiogenesis will provide an important foundation for our understanding of cardiac defects. ..
  54. MICROCIRCULATORY DYNAMICS IN THE CORONARY CIRCULATION
    WILLIAM CHILIAN; Fiscal Year: 2008
    ..dilation, which we believe is a response that facilitates communication of metabolic signals throughout the coronary circulation. The first objective is to elucidate a critical factor that is one of the causal links between coronary ..
  55. Invasive Assessment of the Coronary Microcirculation
    William Fearon; Fiscal Year: 2008
    ..abstract_text> ..
  56. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..The long-term goal of this research is to develop optimal therapies to restore the oxidative balance in CAD. ..