cerebrovascular circulation

Summary

Summary: The circulation of blood through the vessels of the BRAIN.

Top Publications

  1. ncbi Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity
    Diego Centonze
    Department of Neuroscience, University Hospital Tor Vergata, Rome, Italy
    Ann Neurol 70:51-8. 2011
  2. ncbi No cerebrocervical venous congestion in patients with multiple sclerosis
    Florian Doepp
    Department of Neurology, University Hospital Charite, Humboldt University, Berlin, Germany
    Ann Neurol 68:173-83. 2010
  3. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
  4. ncbi Progressive multiple sclerosis is not associated with chronic cerebrospinal venous insufficiency
    C Baracchini
    First Neurology Clinic, Department of Neuroscience, University of Padua, Padova, Italy
    Neurology 77:844-50. 2011
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
  6. ncbi Interpreting the BOLD signal
    Nikos K Logothetis
    Max Planck Institut für biologische Kybernetik, Tubingen, Germany
    Annu Rev Physiol 66:735-69. 2004
  7. ncbi Cerebral microvascular pathology in aging and Alzheimer's disease
    E Farkas
    Department of Animal Physiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Prog Neurobiol 64:575-611. 2001
  8. pmc Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields
    Weiying Dai
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 60:1488-97. 2008
  9. ncbi Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
    Micaela Zonta
    Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
    Nat Neurosci 6:43-50. 2003
  10. ncbi Neurovascular mechanisms of Alzheimer's neurodegeneration
    Berislav V Zlokovic
    Frank P Smith Laboratories for Neuroscience and Neurological Surgery Research, Department of Neurological Surgery and Division of Neurovascular Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Trends Neurosci 28:202-8. 2005

Detail Information

Publications303 found, 100 shown here

  1. ncbi Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity
    Diego Centonze
    Department of Neuroscience, University Hospital Tor Vergata, Rome, Italy
    Ann Neurol 70:51-8. 2011
    ..This information is particularly relevant, because uncontrolled surgical procedures are increasingly offered to MS patients to treat their venous stenoses...
  2. ncbi No cerebrocervical venous congestion in patients with multiple sclerosis
    Florian Doepp
    Department of Neurology, University Hospital Charite, Humboldt University, Berlin, Germany
    Ann Neurol 68:173-83. 2010
    ....
  3. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
    ..The data reviewed here support an essential role of neurovascular and BBB mechanisms in contributing to both, onset and progression of AD...
  4. ncbi Progressive multiple sclerosis is not associated with chronic cerebrospinal venous insufficiency
    C Baracchini
    First Neurology Clinic, Department of Neuroscience, University of Padua, Padova, Italy
    Neurology 77:844-50. 2011
    ..Thus, we studied CCSVI prevalence in primary progressive (PP) and secondary progressive (SP) MS, to clarify whether CCSVI characterizes the progressive forms of this disease...
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity...
  6. ncbi Interpreting the BOLD signal
    Nikos K Logothetis
    Max Planck Institut für biologische Kybernetik, Tubingen, Germany
    Annu Rev Physiol 66:735-69. 2004
    ..We conclude with a discussion of how to use the BOLD signal to make inferences about the neural signal...
  7. ncbi Cerebral microvascular pathology in aging and Alzheimer's disease
    E Farkas
    Department of Animal Physiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Prog Neurobiol 64:575-611. 2001
    ..Finally, a set of animal models are going to be presented that are frequently used to uncover the functional relationship between cerebrovascular factors and the damage to neural networks...
  8. pmc Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields
    Weiying Dai
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 60:1488-97. 2008
    ..Imaging at 3T with body coil transmission was readily achieved. This technique should help to realize the benefits of continuous labeling in clinical imagers...
  9. ncbi Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
    Micaela Zonta
    Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
    Nat Neurosci 6:43-50. 2003
    ..Taken together, our findings show that neuron-to-astrocyte signaling is a key mechanism in functional hyperemia...
  10. ncbi Neurovascular mechanisms of Alzheimer's neurodegeneration
    Berislav V Zlokovic
    Frank P Smith Laboratories for Neuroscience and Neurological Surgery Research, Department of Neurological Surgery and Division of Neurovascular Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Trends Neurosci 28:202-8. 2005
    ....
  11. pmc Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease
    Tracy R Melzer
    Van der Veer Institute for Parkinson s and Brain Research, Christchurch 8011, New Zealand
    Brain 134:845-55. 2011
    ....
  12. ncbi Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele
    Sun Mi Kim
    Department of Radiology, Graduate School of Medicine, Kyung Hee University, Seoul, South Korea
    Neuroradiology 55:25-34. 2013
    ....
  13. ncbi Robustly measuring vascular reactivity differences with breath-hold: normalising stimulus-evoked and resting state BOLD fMRI data
    Kevin Murphy
    Cardiff University Brain Research Imaging Centre CUBRIC, School of Psychology, Cardiff University, Cardiff, UK
    Neuroimage 54:369-79. 2011
    ..This demonstrates that individual end-tidal CO(2) increases to breath-hold should be accounted for to provide an accurate measure of vascular reactivity resulting in more statistically active voxels in group level analyses...
  14. pmc The physiological origin of task-evoked systemic artefacts in functional near infrared spectroscopy
    Evgeniya Kirilina
    Free Univ Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
    Neuroimage 61:70-81. 2012
    ..Therefore a careful separation of fNIRS signals originating from activated brain and from scalp is a necessary precondition for unbiased fNIRS brain activation maps...
  15. pmc Review: cerebral microvascular pathology in ageing and neurodegeneration
    W R Brown
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, USA
    Neuropathol Appl Neurobiol 37:56-74. 2011
    ..Donepezil has shown some benefit. Emboli, such as clots, cholesterol crystals and microspheres can be extruded through the walls of cerebral vessels, but there is no evidence yet that lipid emboli undergo such extravasation...
  16. ncbi Assessment of cerebral venous return by a novel plethysmography method
    Paolo Zamboni
    Vascular Diseases Centre, University of Ferrara, Ferrara, Italy
    J Vasc Surg 56:677-85.e1. 2012
    ..The purpose of this study was to assess the cerebral venous return in relation to the change in position by means of a novel cervical plethysmography method...
  17. ncbi Influence of skin blood flow on near-infrared spectroscopy signals measured on the forehead during a verbal fluency task
    Toshimitsu Takahashi
    Department of Neurophysiology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Neuroimage 57:991-1002. 2011
    ..43). These results suggest that a major part of the task-related changes in the oxyHb concentration in the forehead is due to task-related changes in the skin blood flow, which is under different autonomic control than heart rate...
  18. ncbi The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Neurol Sci 282:21-7. 2009
    ..0001). Moreover, this study demonstrates a significant impairment of cerebral venous drainage in patients affected by MS, a mechanism potentially related to increased iron stores...
  19. ncbi Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
    Sean J Mulligan
    Brain Research Centre, Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
    Nature 431:195-9. 2004
    ..Vasoconstriction by astrocytes is a previously unknown mechanism for the regulation of CBF...
  20. ncbi Glioma grading by using histogram analysis of blood volume heterogeneity from MR-derived cerebral blood volume maps
    Kyrre E Emblem
    Departments of Medical Physics, Rikshospitalet Radiumhospitalet Medical Centre, Sognsvannsveien 20, N 0027 Oslo, Norway
    Radiology 247:808-17. 2008
    ....
  21. ncbi Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
    Helen S Mayberg
    Department of Psychiatry and the Rotman Research Institute, University of Toronto, Ontario, Canada
    Br Med Bull 65:193-207. 2003
    ....
  22. ncbi Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
    Helene Girouard
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, USA
    J Appl Physiol 100:328-35. 2006
    ..These findings, collectively, highlight the importance of neurovascular coupling to the health of the normal brain and suggest a therapeutic target for improving brain function in pathologies associated with cerebrovascular dysfunction...
  23. ncbi Multiple sclerosis: cerebral circulation time
    Marcello Mancini
    Institute of Biostructure and Bioimaging, National Research Council of Italy, Federico II University School of Medicine, Via Pansini 5, Edificio 10, 80131 Naples, Italy
    Radiology 262:947-55. 2012
    ..To assess cerebral circulation times (CCTs) in patients with multiple sclerosis (MS) and control subjects by using contrast material-enhanced ultrasonography (US) to determine whether vascular abnormalities can be detected in this disease...
  24. ncbi Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter
    Meng Law
    Departments of Radiology and Neurology, New York University Medical Center, MRI Department, Schwartz Building, Basement HCC, 530 First Avenue, New York, NY 10016, USA
    Radiology 231:645-52. 2004
    ....
  25. ncbi Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements
    Matthias Gunther
    Advanced MRI Technologies, Sebastopol, California 95472, USA
    Magn Reson Med 54:491-8. 2005
    ..For arterial spin labeling, single-shot 3D imaging techniques are optimal in terms of efficiency and might prove beneficial to improve reliability of perfusion quantitation in a clinical setup...
  26. ncbi The identification of interacting networks in the brain using fMRI: Model selection, causality and deconvolution
    Alard Roebroeck
    Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Postbus 616, 6200MD Maastricht, The Netherlands
    Neuroimage 58:296-302. 2011
    ..However, it is crucially dependent upon assumptions that need to be verified...
  27. pmc Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury
    Martin Lauritzen
    Department of Clinical Neurophysiology, Glostrup Hospital, Glostrup, Denmark
    J Cereb Blood Flow Metab 31:17-35. 2011
    ....
  28. ncbi Assessment of arterial arrival times derived from multiple inversion time pulsed arterial spin labeling MRI
    Bradley J MacIntosh
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Magn Reson Med 63:641-7. 2010
    ..Pulsed arterial spin labeling signals were simulated using an identical sampling scheme as the empiric study and revealed AAT can be estimated robustly when simulated arrival times are well beyond the normal range...
  29. ncbi Modeling the hemodynamic response to brain activation
    Richard B Buxton
    Department of Radiology, 0677, and Center for Functional MRI, University of California San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 23:S220-33. 2004
    ..This approach has the potential to enhance numerous studies of brain function in development, health, and disease...
  30. ncbi Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction
    Shahar Lavi
    J Recanati Autonomic Dysfunction Center, Medicine A, Rambam Medical Center, PO Box 9602, Haifa 31096, Israel
    Am J Physiol Heart Circ Physiol 291:H1856-61. 2006
    ..This supports our hypothesis that NO is involved in CO(2)-dependent CBF regulation alone. CBFV chemoregulation could therefore be a surrogate of local cerebral endothelial function...
  31. ncbi Cerebral microvessel responses to focal ischemia
    Gregory J del Zoppo
    of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 132, La Jolla, CA 92037, U S A
    J Cereb Blood Flow Metab 23:879-94. 2003
    ....
  32. ncbi Physiology of cerebral venous blood flow: from experimental data in animals to normal function in humans
    B Schaller
    Max Planck Institute for Neurological Research, Gleueler Strasse 50, D 50931 Cologne, Germany
    Brain Res Brain Res Rev 46:243-60. 2004
    ..In the light of this increasing interest in the cerebral venous system, the authors have summarized the current knowledge of the physiology of the cerebrovenous system and discuss it is in the light of its clinical relevance...
  33. ncbi Delayed cell death related to acute cerebral blood flow changes following subarachnoid hemorrhage in the rat brain
    Giselle F Prunell
    Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    J Neurosurg 102:1046-54. 2005
    ....
  34. pmc Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's disease
    Guofan Xu
    GRECC, Madison VA Hospital, Madison, WI, USA
    NMR Biomed 23:286-93. 2010
    ..pcASL perfusion MRI offers an alternative method for non-invasive in vivo examination of early pathophysiological changes in AD...
  35. ncbi The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics
    P Zamboni
    Vascular Diseases Center, University of Ferrera, and Bellaria Neurosciences, Ferrara and Bologna, Italy
    Funct Neurol 24:133-8. 2009
    ..027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). This study demonstrates that venous outflow disturbances in the form of CCSVI significantly impact on CSF pathophysiology in patients with MS...
  36. ncbi Mapping cerebrovascular reactivity using blood oxygen level-dependent MRI in Patients with arterial steno-occlusive disease: comparison with arterial spin labeling MRI
    Daniel M Mandell
    Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    Stroke 39:2021-8. 2008
    ..The purpose of this study was to determine whether, in patients with stenoocclusive disease, the BOLD MRI signal response to hypercapnia is directly related to changes in cerebral blood flow...
  37. ncbi Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance
    Jacques de Keyser
    Department of Neurology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    J Cereb Blood Flow Metab 28:1645-51. 2008
    ....
  38. pmc Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience
    Nathan A Johnson
    MR Research Unit, VA Medical Center, 4150 Clement St 114M San Francisco, CA 94107, USA
    Radiology 234:851-9. 2005
    ....
  39. ncbi Cell-cell signaling in the neurovascular unit
    Josephine Lok
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, MGH East 149 2401, Charlestown, MA 02129, USA
    Neurochem Res 32:2032-45. 2007
    ....
  40. ncbi Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
    Kiyoshi Niwa
    Center for Clinical and Molecular Neurobiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Neurobiol Dis 9:61-8. 2002
    ..These observations support the hypothesis that cerebrovascular and metabolic abnormalities are early events in the pathogenesis of Alzheimer's disease...
  41. ncbi Relative cerebral blood volume measurements in intracranial mass lesions: interobserver and intraobserver reproducibility study
    Stephan G Wetzel
    Department of Radiology, New York University School of Medicine, 550 First Ave, NY 10016, USA
    Radiology 224:797-803. 2002
    ..To assess inter- and intraobserver reproducibility for different techniques of measuring relative cerebral blood volume (rCBV) in patients with intracranial mass lesions...
  42. ncbi Modeling low-frequency fluctuation and hemodynamic response timecourse in event-related fMRI
    Kendrick N Kay
    Department of Psychology, University of California, Berkeley, CA 94720, USA
    Hum Brain Mapp 29:142-56. 2008
    ..For the analysis techniques we present, we evaluate improvement in modeling accuracy via 10-fold cross-validation...
  43. pmc Static and dynamic characteristics of cerebral blood flow during the resting state
    Qihong Zou
    Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Neuroimage 48:515-24. 2009
    ..The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions...
  44. ncbi Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis
    Andrew J Farrall
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Neurobiol Aging 30:337-52. 2009
    ..30, 0.89, p<0.01). BBB permeability increases with normal ageing and may be an important mechanism in the initiation or worsening of cerebral microvascular disease. Further studies on the role of BBB permeability are urgently needed...
  45. pmc Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx
    Ze Wang
    Center for Functional Neuroimaging and Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 26:261-9. 2008
    ..The implementation of all ASL data processing approaches is easily accomplished within an open-source toolbox, ASLtbx, and is advocated for most perfusion fMRI data sets...
  46. ncbi Beyond the visible--imaging the human brain with light
    Hellmuth Obrig
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    J Cereb Blood Flow Metab 23:1-18. 2003
    ..The authors conclude that NIRS imaging has two major advantages: it can address issues concerning neurovascular coupling in the human adult and can extend functional imaging approaches to the investigation of the diseased brain...
  47. ncbi Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke
    Max Wintermark
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Stroke 37:979-85. 2006
    ....
  48. ncbi Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Neurol 22:348-55. 2009
    ....
  49. pdf No association of abnormal cranial venous drainage with multiple sclerosis: a magnetic resonance venography and flow-quantification study
    Mike P Wattjes
    MS Center Amsterdam, Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:429-35. 2011
    ..This study aimed to investigate the intracranial and extracranial venous anatomy and the intracerebral venous flow profile in patients with MS and healthy controls using magnetic resonance venography (MRV)...
  50. pmc Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease
    Eric P Meyer
    Department of Zoology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:3587-92. 2008
    ..The characteristic early onset of vascular alterations suggests that imaging blood flow and/or vasculature architecture could be used as a tool for early diagnosis of the disease and to monitor therapies...
  51. ncbi Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits
    Xin Kang Tong
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 32:4705-15. 2012
    ..They further indicate that simvastatin and, possibly, other brain penetrant statins bear high therapeutic promise in early AD and in patients with vascular diseases who are at risk of developing AD...
  52. ncbi Chronic cerebrospinal venous insufficiency and multiple sclerosis
    Omar Khan
    Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48323, USA
    Ann Neurol 67:286-90. 2010
    ..At present, invasive and potentially dangerous endovascular procedures as therapy for patients with MS should be discouraged until such studies have been completed, analyzed, and debated in the scientific arena...
  53. ncbi Posttreatment high-grade glioma: usefulness of peak height position with semiquantitative MR perfusion histogram analysis in an entire contrast-enhanced lesion for predicting volume fraction of recurrence
    Ho Sung Kim
    Department of Diagnostic Radiology, Ajou University School of Medicine, Yeongtong Gu, Suwon, Gyeonggi do 442 749, Korea
    Radiology 256:906-15. 2010
    ....
  54. pmc Quantitative ColourDopplerSonography evaluation of cerebral venous outflow: a comparative study between patients with multiple sclerosis and controls
    Lucia Monti
    Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences, Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy
    PLoS ONE 6:e25012. 2011
    ..The purpose of this study was to evaluate CDS quantification of the cerebral venous outflow (CVF) in healthy subjects and patients with multiple sclerosis (MS)...
  55. ncbi Cerebral blood flow regulation by nitric oxide: recent advances
    Noboru Toda
    Shiga University of Medical Science, Toyama Institute for Cardiovascular Pharmacology Research, 7 13, 1 chome, Azuchi machi, Chuo Ku, Osaka 541 0052, Japan
    Pharmacol Rev 61:62-97. 2009
    ..This information would contribute to better understanding of cerebral hemodynamic regulation and its dysfunction and to development of novel therapeutic measures to treat diseases of the central nervous system...
  56. pmc Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage
    Jens P Dreier
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Brain 132:1866-81. 2009
    ....
  57. ncbi Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats
    Jing Ye Wang
    Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Stroke 39:983-90. 2008
    ..In this study, we tested the hypothesis that ischemic postconditioning reduces global cerebral ischemia/reperfusion-induced structural and functional injury in rats...
  58. ncbi Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis
    A Thapar
    Imperial College London, London UK
    Phlebology 26:319-25. 2011
    ..We performed a systematic review to establish the prevalence and strength of association between sonographic CCSVI and multiple sclerosis (MS)...
  59. ncbi Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse
    Zheng Gang Zhang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich, USA
    Circ Res 90:284-8. 2002
    ....
  60. ncbi Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds
    Krishna A Dani
    Department of Neurology, Institute of Neurological Sciences, University of Glasgow Southern General Hospital, Glasgow, Scotland
    Ann Neurol 70:384-401. 2011
    ..The optimum perfusion values to identify tissue at risk of infarction in acute stroke are unclear. We systematically reviewed CT and MR perfusion imaging in acute ischemic stroke...
  61. ncbi Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging
    Meng Law
    Department of Radiology, New York University Medical Center, NY, USA
    AJNR Am J Neuroradiol 24:1989-98. 2003
    ..We evaluated the sensitivity, specificity, PPV, and NPV of perfusion MR imaging and MR spectroscopy compared with conventional MR imaging in grading primary gliomas...
  62. ncbi Astrocytes and the regulation of cerebral blood flow
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Trends Neurosci 32:160-9. 2009
    ..Thus, astrocytes have a pivotal role in dynamic signaling within the neurovascular unit. Important questions remain on how this signaling is integrated with other pathways in health and disease...
  63. ncbi Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:164-74. 2003
    ..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics...
  64. pmc Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue
    Sava Sakadzic
    Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Nat Methods 7:755-9. 2010
    ..The properties of the probe allowed for direct high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities for functional metabolic brain studies...
  65. pmc Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation
    Mohammad A Yaseen
    Department of Radiology, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 31:1051-63. 2011
    ..Understanding O(2) supply on a microscopic level will yield better insight into brain function and the underlying mechanisms of various neuropathologies...
  66. ncbi Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats
    Heng Zhao
    Department of Neurosurgery, Stanford University, California 94305 5327, USA
    J Cereb Blood Flow Metab 26:1114-21. 2006
    ..In conclusion, postconditioning reduced infarct size, most plausibly by blocking apoptosis and free radical generation. With further study it may eventually be clinically applicable for stroke treatment...
  67. pmc Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
    Charles W Leffler
    Dept of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    J Appl Physiol (1985) 100:1065-76. 2006
    ..Both the HO-CO and CSE-H2S systems have potential to interact with NO and prostanoids in the cerebral circulation. Much of the physiology and biochemistry of HO-CO and CSE-H2S in the cerebral circulation remains open for exploration...
  68. ncbi A phase-contrast MRI study of physiologic cerebral venous flow
    Souraya Stoquart-ElSankari
    Department of Imaging and Biophysics, Amiens University Hospital, Amiens Cedex, France
    J Cereb Blood Flow Metab 29:1208-15. 2009
    ..The pulsatility of venous outflow and the role it plays in the regulation of intracranial pressure require further investigation...
  69. pmc The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
    Costantino Iadecola
    Division of Neurobiology, Weill Cornell Medical College, New York, NY 10065, USA
    Acta Neuropathol 120:287-96. 2010
    ....
  70. pmc Hypertension and cerebrovascular dysfunction
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10021, USA
    Cell Metab 7:476-84. 2008
    ..This review focuses on the mechanisms by which hypertension disrupts cerebral blood vessels, highlighting recent advances and outstanding issues...
  71. ncbi Arterial spin labeling in combination with a look-locker sampling strategy: inflow turbo-sampling EPI-FAIR (ITS-FAIR)
    M Gunther
    Deutsches Krebsforschungszentrum DKFZ, Forschungsschwerpunkt Radiologische Diagnostik und Therapie E0201, Heidelberg, Germany
    Magn Reson Med 46:974-84. 2001
    ..With the ability to obtain ITS-FAIR time series with high temporal resolution arterial transit times in the range of -138 - 1054 ms were measured, where nonphysical negative values were found in voxels containing large vessels...
  72. pmc Mapping and correction of vascular hemodynamic latency in the BOLD signal
    Catie Chang
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Neuroimage 43:90-102. 2008
    ....
  73. pmc Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Lancet Neurol 6:258-68. 2007
    ....
  74. ncbi Principles of magnetic resonance assessment of brain function
    David G Norris
    FC Donders Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
    J Magn Reson Imaging 23:794-807. 2006
    ....
  75. ncbi Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation
    T Neumann-Haefelin
    Department of Radiology, Lucas MRS MRI Center, Stanford Stroke Center, Stanford University, CA, USA
    Stroke 31:1965-72; discussion 1972-3. 2000
    ....
  76. ncbi Is cortical vasculature functionally organized?
    Justin L Gardner
    Gardner Research Unit, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neuroimage 49:1953-6. 2010
    ..If the cortical vasculature is built to serve these needs, it may also tend to aggregate and amplify orientation specific signals and explain why they are available in fMRI data at very low resolution...
  77. ncbi Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study
    Peter Vajkoczy
    Department of Neurosurgery, University Hospital Mannheim, and Faculty for Clinical Medicine, Karl Ruprecht University of Heidelberg, Mannheim, Switzerland
    J Neurosurg 103:9-17. 2005
    ....
  78. ncbi An integrative model for neuronal activity-induced signal changes for gradient and spin echo functional imaging
    Kamil Uludag
    Max Planck Institute for Biological Cybernetics, Hochfeld Magnetresonanz Zentrum, Spemannstr 41, Tubingen 72076, Germany
    Neuroimage 48:150-65. 2009
    ..The model, and the physiological considerations presented here can also be applied in contrast agent experiments and to other models, such as calibrated BOLD approach and vessel size imaging...
  79. ncbi Spreading depolarizations occur in human ischemic stroke with high incidence
    Christian Dohmen
    Department of Neurology, University of Cologne, Cologne, Germany
    Ann Neurol 63:720-8. 2008
    ..For decades it has been questioned whether CSD or PID occur in human ischemic stroke. Here, we describe CSD and PID in patients with malignant middle cerebral artery infarction detected by subdural electrocorticography (ECoG)...
  80. ncbi Venous collateral circulation of the extracranial cerebrospinal outflow routes
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 6:204-12. 2009
    ....
  81. ncbi Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
    ..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage...
  82. ncbi The microvascular system of the striate and extrastriate visual cortex of the macaque
    Bruno Weber
    Max Planck Institut für biologische Kybernetik, Spemannstr 38, 72076 Tubingen, Germany
    Cereb Cortex 18:2318-30. 2008
    ....
  83. ncbi The effect of exercise on the cerebral vasculature of healthy aged subjects as visualized by MR angiography
    E Bullitt
    Department of Surgery, University of North Carolina, Chapel Hill, NC, USA
    AJNR Am J Neuroradiol 30:1857-63. 2009
    ..The purpose of this blinded study was to compare high-activity and low-activity healthy elderly volunteers for differences in the cerebrovasculature as calculated from vessels extracted from noninvasive MR angiograms (MRAs)...
  84. pmc Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients
    L Meng
    Department of Anesthesiology and Perioperative Care, University of California, Irvine Medical Center, 101 The City Drive South, Bldg 53, Rm 227, Orange, CA 92868, USA
    Br J Anaesth 107:209-17. 2011
    ..The physiological variables responsible for Sct(O2) changes induced by phenylephrine and ephedrine bolus treatment in anaesthetized patients need to be defined...
  85. pmc Basal cerebral blood volume during the poststimulation undershoot in BOLD MRI of the human brain
    Peter Dechent
    MR Research in Neurology and Psychiatry, Georg August Universitat, Gottingen, Germany
    J Cereb Blood Flow Metab 31:82-9. 2011
    ..With the assumption of normalized cerebral blood flow after stimulus cessation, a normalized CBV lends support to the idea that the BOLD MRI undershoot reflects a prolonged elevation of oxidative metabolism...
  86. ncbi Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network: Part I: methodology and baseline flow
    S Lorthois
    Institut de Mécanique des Fluides de Toulouse, UMR CNRS INP UPS 5502, Toulouse, France
    Neuroimage 54:1031-42. 2011
    ....
  87. pmc Applications of arterial spin labeled MRI in the brain
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 35:1026-37. 2012
    ..This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care...
  88. ncbi Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits
    Andrzej F Frydrychowski
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 82:156-62. 2011
    ..This study was performed: 1) to assess the relationship between blood flow velocity in the internal carotid artery (CBF(ICA)) and pial artery pulsation (cc-TQ) and 2) to evaluate flow-induced changes in pial artery compliance...
  89. pmc "Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels
    Anna Devor
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02114, USA
    J Neurosci 31:13676-81. 2011
    ....
  90. pmc Methamphetamine causes sustained depression in cerebral blood flow
    Oksana Polesskaya
    Department of Microbiology and Immunology, The University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Brain Res 1373:91-100. 2011
    ..These findings show that even a single, acute exposure to MA can result in profound changes in CBF, with potentially deleterious consequences for brain function...
  91. pmc Cerebral perfusion and aortic stiffness are independent predictors of white matter brain atrophy in type 1 diabetic patients assessed with magnetic resonance imaging
    Saskia G C van Elderen
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 34:459-63. 2011
    ..To identify vascular mechanisms of brain atrophy in type 1 diabetes mellitus (DM) patients by investigating the relationship between brain volumes and cerebral perfusion and aortic stiffness using magnetic resonance imaging (MRI)...
  92. ncbi Effects of acute hypercapnia on the amplitude of cerebrovascular pulsation in humans registered with a non-invasive method
    Andrzej F Frydrychowski
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 83:229-36. 2012
    ..The aim of the study was to assess non-invasively the effects of acute hypercapnia on the amplitude of cerebrovascular pulsation (CVP) in humans...
  93. pmc Test-retest reliability of arterial spin labeling with common labeling strategies
    Yufen Chen
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    J Magn Reson Imaging 33:940-9. 2011
    ..To compare the test-retest reproducibility of three variants of arterial spin labeling (ASL): pseudo-continuous (pCASL), pulsed (PASL) and continuous (CASL)...
  94. ncbi Reperfusion for acute ischemic stroke: arterial revascularization and collateral therapeutics
    David S Liebeskind
    UCLA Stroke Center, Los Angeles, California 90095, USA
    Curr Opin Neurol 23:36-45. 2010
    ..This overview of the literature relating to reperfusion in acute ischemic stroke published within the last year provides a snapshot of a rapidly evolving aspect of cerebrovascular disease...
  95. ncbi Decreased cerebral perfusion and oxidative stress result in acute and delayed cognitive impairment
    Hui Liu
    Department of Neurology, Zhongnan Hospital, Wuhan University, Donghu Road 169, Wuhan 430071, China
    Curr Neurovasc Res 9:152-8. 2012
    ..Moreover, data support the notion that cognitive impairment in CCH rat models may be induced early by cerebral hypoperfusion early and in a later phase by oxidative stress...
  96. ncbi Deep and surface hemodynamic signal from functional time resolved transcranial near infrared spectroscopy compared to skin flowmotion
    Federico Aletti
    Dipartimento di Bioingegneria IIT Unit, Politecnico di Milano, Milan, Italy
    Comput Biol Med 42:282-9. 2012
    ..The deep cortical NIRS signal did not appear to be affected by surface vasomotor activity, and autoregulation dynamics were dominant with respect to autonomic control of circulation...
  97. ncbi The investigation of functional brain lateralization by transcranial Doppler sonography
    Michael Deppe
    Department of Neurology, University of Munster, D 48129 Munster, Germany
    Neuroimage 21:1124-46. 2004
    ....
  98. ncbi Effects of the Valsalva maneuver on pial artery pulsation and subarachnoid width in healthy adults
    Magdalena Wszedybyl-Winklewska
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 82:369-73. 2011
    ....
  99. ncbi Characterizing photothrombotic distal middle cerebral artery occlusion and YAG laser-induced reperfusion model in the Izumo strain of spontaneously hypertensive rats
    Hiroshi Yao
    National Hospital Organization Hizen Psychiatric Center, Saga, Japan
    Cell Mol Neurobiol 31:57-63. 2011
    ..These data suggest that this stroke model in SHR/Izm is useful in the preclinical testing of stroke therapies and elucidating the pathophysiology of cerebral ischemia/reperfusion...
  100. pmc The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension
    Carmen Capone
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA
    Am J Physiol Heart Circ Physiol 300:H397-407. 2011
    ....
  101. ncbi Cerebrovascular and cardiovascular pathology in Alzheimer's disease
    Jack C de la Torre
    Sun Health Research Institute, Center for Alzheimer s Research, Sun City, Arizona 85351, USA
    Int Rev Neurobiol 84:35-48. 2009
    ..Considerable human data now point in a new direction for guiding future research into AD. This new research direction should open a window of opportunity for decisive management and treatment of this devastating disorder...

Research Grants72

  1. Hydrogen Sulfide in Newborn Cerebral Circulation
    Charles W Leffler; Fiscal Year: 2013
    ..Control of cerebrovascular circulation is easily impaired by pathological conditions...
  2. CARBON MONOXIDE IN NEWBORN CEREBRAL CIRCULATION
    CHARLES LEFFLER; Fiscal Year: 2009
    ..Control of cerebrovascular circulation is easily impaired by pathological conditions...
  3. VON WILLEBRAND FACTOR AND THE PATHOPHYSIOLOGY OF TTP
    Joel Moake; Fiscal Year: 1990
    ..be applicable to the study of common arterial thrombotic disorders involving regions of the coronary or cerebrovascular circulation. We also expect that the results of our study will make possible molecular level on TTP and related ..
  4. Enhancement of Thrombolysis through Inhibition of PAI-1 and Antiplasmin
    CHARLENE BLAKE; Fiscal Year: 2007
    ..provided by applicant): Over 80% of all strokes result from the presence of a thrombus occluding the cerebrovascular circulation. Definitive treatment of these strokes involves thrombolysis, that is, dissolution of the blood clot...
  5. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  6. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  7. Measurement of Absolute Cerebral Blood Volume using Magnetic Resonance Imaging
    Hanzhang Lu; Fiscal Year: 2008
    ..In this project, a new technique will be developed to measure CBV in human brain using MRI. [unreadable] [unreadable] [unreadable]..
  8. MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2004
    ..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
  9. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  10. Study of Carotid Occlusion and Neurocognition (RECON)
    RANDOLPH MARSHALL; Fiscal Year: 2009
    ....
  11. Role of COX-2 Gene Expression in Ischemic Brain Damage
    Costantino Iadecola; Fiscal Year: 2010
    ..abstract_text> ..
  12. Microvascular injury after Subarachnoid Hemorrhage
    Fatima A Sehba; Fiscal Year: 2010
    ....
  13. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  14. Neurovascular Coupling in Hypertension
    Costantino Iadecola; Fiscal Year: 2004
    ..The results of these studies will enhance our understanding of the effects of hypertension on the brain and may provide new insights into treatment strategies aimed at counteracting these detrimental actions. ..
  15. EXPERIMENTAL NEUROGENIC HYPERTENSION PROGRAM
    Costantino Iadecola; Fiscal Year: 2008
    ..The proposed studies are relevant to human diseases, such as hypertension-induced cognitive dysfunction, cardiovascular complications of sleep apnea, and cardiovascular diseases in post-menopausal women. ..
  16. Prostanoid Receptors and Ischemic Brain Injury
    Costantino Iadecola; Fiscal Year: 2010
    ..abstract_text> ..
  17. COGNITIVE AND CEREBROVASCULAR SEQUELAE OF HYPERTENSION
    J Jennings; Fiscal Year: 2004
    ..Successful completion will clarify a) how one major disease of aging reduces intellectual functioning and b) permit a rational choice of clinical regimen to treat this disease while minimizing neuropsychological side effects. ..
  18. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  19. Advanced NeuroImaging for Acute Stroke Treatment
    Max Wintermark; Fiscal Year: 2007
    ..Invited junior scientists, for whom funding is requested, were selected based on merit. [unreadable] [unreadable] [unreadable]..
  20. 9.4 T/31 cm Bore MR Instrument
    Seong Gi Kim; Fiscal Year: 2002
    ..Combining MR imaging and conventional physiology research in a synergistic fashion, the new imaging facility with the proposed 9.4T MR system will play a central role in biomedical MR research. ..
  21. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  22. PHARMACOLOGIC DISSECTION OF THE HPA AXIS IN ALCOHOLISM
    Bryon Adinoff; Fiscal Year: 2002
    ....
  23. Evaluation of New Imaging Methodologies at 7T
    EWART HAACKE; Fiscal Year: 2007
    ..Many of the approaches developed and applied on this animal system are expected to have important clinical impact. All of these projects will substantially benefit from the proposed acquisition. [unreadable] [unreadable] [unreadable]..
  24. PET IMAGING AND COCAINE NEUROPHARMACOLOGY IN MONKEYS
    Leonard Howell; Fiscal Year: 2006
    ..The results obtained will also evaluate the effectiveness of monoamine transporters as potential targets for cocaine medications development. ..
  25. FUNCTIONAL MRI AT COLUMNAR RESOLUTION
    Seong Gi Kim; Fiscal Year: 2002
    ..Further insight into functional columnar organization in animals and humans will greatly facilitate our basic understanding of the structure, development and plasticity of cortical maps. ..
  26. Cerebral Vasoregulation In Elderly with Stroke
    Vera Novak; Fiscal Year: 2007
    ..The results of this study may improve our understanding of optimal BP targets for the maintenance of cerebral perfusion in elderly people with stroke. ..
  27. Heme oxygenase and cerebral vascular injury
    Helena Parfenova; Fiscal Year: 2008
    ..Better understanding of the mechanisms of postictal cerebral vascular dysfunction is needed to improve the long-term neurological outcome in human newborns. ..
  28. Dynamical Assessment of Cerebral Autoregulation
    Vera Novak; Fiscal Year: 2007
    ..Therefore, this project may have substantial socioeconomic impact. [unreadable] [unreadable] [unreadable]..
  29. Arterial Spin Labeling for fMRI
    Eric Wong; Fiscal Year: 2002
    ....
  30. Cerebromicrovascular disease in elderly with diabetes
    Vera Novak; Fiscal Year: 2010
    ..This study will provide new data and biomarkers on cerebral perfusion and functional outcomes in type 2 DM, that can be used to initialize the efforts to implement brain protection as a new target for prevention of DM complications. ..
  31. Susceptibility Weighted Imaging (SWI)
    EWART MARK HAACKE; Fiscal Year: 2010
    ..Recently, SWI has also become available to the clinical world for every day use and therefore its continued technical development is of paramount importance for the proper diagnosis of these diseases in patients. ..
  32. CEREBRAL MITOCHONDRIAL METABOLISM IN NEURODEGENERATION
    William Powers; Fiscal Year: 2004
    ..If such studies yield consistent results, they will establish the basis for the utilization of platelet rnitochondrial function assays to monitor cerebral mitochondrial metabolism. ..
  33. PHYSIOLOGICAL BASIS OF FUNCTIONAL MRI SIGNALS
    Seong Gi Kim; Fiscal Year: 2002
    ....
  34. Neurovascular Factors in Functional MRI
    Thomas T Liu; Fiscal Year: 2010
    ..The specific aims of this project are to identify the measures that most effectively explain changes in resting-state connectivity due to (a) caffeine usage and (b) inter-subject differences in physiology. ..
  35. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2005
    ..Our competing renewal will be used to identify specific changes in these neuroreceptor systems, providing avenues for new pharmacologic investigations in the treatment of cocaine dependence. ..
  36. Development of Arterial Spin Labeling for Clinical Applications
    Eric Wong; Fiscal Year: 2009
    ..The result of this work will be robust methods for measuring not only the amount of perfusion, but also the vascular source from which that perfusion was derived. ..
  37. Transitional States in Drug Addiction
    Leonard Howell; Fiscal Year: 2007
    ..These integrated efforts, including behavioral and mechanistic approaches, will provide a comprehensive analysis to elucidate transitional states in cocaine addiction. [unreadable] [unreadable]..
  38. Fast, Quantitative, Perfusion-Based functional-MRI
    Luis Hernandez Garcia; Fiscal Year: 2007
    ..These developments will be quite instrumental to the use of ASL perfusion imaging as a powerful tool for the study of brain function. ..
  39. ATHEROSCLEROSIS AND CEREBRAL ISCHEMIA
    Paul Huang; Fiscal Year: 2008
    ..They also provide proof of principle for approaches that directly target cerebral vascular dysfunction for the treatment and prevention of stroke. ..
  40. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  41. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  42. Endothelial Function in the Cerebral Circulation
    Frank Faraci; Fiscal Year: 2009
    ..These studies should provide new insight into mechanisms of cerebral vascular protection during hypertension. ..
  43. Vascular inflammation and neurotoxicity in aging brain
    Paula Grammas; Fiscal Year: 2009
    ....
  44. Neural and non-neural modulators of skin blood flow and sweating in humans
    CRAIG CRANDALL; Fiscal Year: 2009
    ..e. diabetes, heart failure, etc) and non-disease (i.e. aging) conditions. ..
  45. Internat'l symposium:vascular neuroeffector mechanisms
    SUE DUCKLES; Fiscal Year: 2002
    ..We anticipate that all aspects of this conference will help to foster development of new directions and collaborations in the field. ..
  46. Simutaneous fMRI and EEG of Epileptogenic Brain Regions
    John Stern; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  47. A Data Fusion Method for Bedside Monitoring of Lumped Cerebral Arterial Radii
    Xiao Hu; Fiscal Year: 2008
    ..abstract_text> ..
  48. The Hemodynamic Response to Brain Activation
    Richard Buxton; Fiscal Year: 2005
    ..abstract_text> ..
  49. FOREBRAIN ORGANIZATION IN A NOVEL RAT
    Kevin Lee; Fiscal Year: 2003
    ..The proposed studies will provide fundamental insights into the structure, function and development of a seizure-prone brain with band heterotopia. ..
  50. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  51. Diagnostic Imaging of Cerebral Blood Flow with MRI
    David Alsop; Fiscal Year: 2003
    ..These developments will make reliable CBF imaging by Arterial Spin Labeling a widely applicable technique for diagnostic imaging. ..
  52. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2003
    ..The potential role of PC cytokines will be examined. ..
  53. MRI OF STRUCTURE/FUNCTION IN TEMPORAL LOBE EPILEPSY
    John Detre; Fiscal Year: 2003
    ..Validation of an fMRI protocol for assessing memory function will improve the safety and quality of the preoperative assessment for temporal lobectomy, and may have important implications for neurosurgical planning and prognosis. ..
  54. Cellular Mechanisms of Preterm White Matter Injury
    STEPHEN BACK; Fiscal Year: 2003
    ....
  55. PHYSIOLOGY & PATHOPHYSIOLOGY OF ACTIVATION FLOW COUPLING
    John Detre; Fiscal Year: 2002
    ..These studies will provide further insight into the parameters affecting the AFC response, and will suggest approaches for optimizing and interpreting functional imaging data. ..
  56. MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET
    JOSEPH MANDEVILLE; Fiscal Year: 2001
    ..Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology. ..
  57. Intraoperative Optical Imaging of Brain Function
    Andrew Dunn; Fiscal Year: 2006
    ..abstract_text> ..
  58. Siemens Symbia T SPECT-CT Scanner
    Andrew Newberg; Fiscal Year: 2006
    ..Overall, this scanner will become a major tool for our present and future research programs with a focus on brain SPECT imaging, but also the potential to include many other types of studies. [unreadable] [unreadable]..
  59. eNOS: Metabolism & Vascular Biology in Health & Disease
    M Laughlin; Fiscal Year: 2007
    ..The strong group of investigators submitting this application is uniquely qualified and prepared to accomplish these goals. ..
  60. Diffuse optical brain imaging for stroke rehabilitation
    Gary Strangman; Fiscal Year: 2007
    ..Importantly, use of the DOT technology in such a research program is expected to enable the investigation of tasks and populations that are otherwise beyond the reach of existing brain imaging technologies. [unreadable] [unreadable]..
  61. Is There a Link Between Alzheimer's and Atheroclerosis
    Paula Grammas; Fiscal Year: 2007
    ..abstract_text> ..
  62. CRCNS: Development & Optimization of Magnetic Source MRI
    Jia Hong Gao; Fiscal Year: 2006
    ..The power provided by msMRI technology is essential to understand human cellular neurophysiology and its implication on brain diseases. ..
  63. The Tuning for Complex Visual Stimuli in V1
    Aniruddha Das; Fiscal Year: 2006
    ..abstract_text> ..
  64. Cognitive reserve and age-related brain changes
    Adam Brickman; Fiscal Year: 2005
    ..Results from the study will provide important insights into the normal aging process and will yield valuable information towards understanding the underpinnings of age-associated pathologies. ..
  65. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2002
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  66. Nonesterified Fatty Acids and Cardiovascular Aging
    J Taylor; Fiscal Year: 2006
    ..This work is clinically relevant because these associations may provide insight into the etiology of the increased incidence of cardiovascular disease with age. ..
  67. PATHOPHYSIOLOGIC RESPOSE TO FETAL CARDIAC SURGERY
    Frank Hanley; Fiscal Year: 2005
    ....
  68. Arterial Stiffness & Age-Effects on Circulatory Control
    J Taylor; Fiscal Year: 2007
    ..We seek renewed funding to examine fully sympatho-vagal interactions with age and disease and prospectively assess the effects of exercise. ..
  69. Diffuse Light Imaging of Flow, Oxygen & Brain Metabolism
    Arjun Yodh; Fiscal Year: 2007
    ....
  70. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  71. MENTAL STRESS, AUTONOMIC FUNCTION, AND HEART DISEASE
    J Taylor; Fiscal Year: 2001
    ..Thus, this research may provide unique insight to the mechanism and psycho-physiological correlates of reduced baroreflex sensitivity in CAD patients. ..