atrial function

Summary

Summary: The hemodynamic and electrophysiological action of the HEART ATRIA.

Top Publications

  1. ncbi Atrial cell action potential parameter fitting using genetic algorithms
    Z Syed
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada
    Med Biol Eng Comput 43:561-71. 2005
  2. ncbi Left atrial strain measured by two-dimensional speckle tracking represents a new tool to evaluate left atrial function
    Roberto M Saraiva
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 23:172-80. 2010
  3. ncbi Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis
    Chengqun Huang
    Institute of Molecular Medicine and Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0641, USA
    Development 130:6111-9. 2003
  4. ncbi Left atrial size: physiologic determinants and clinical applications
    Walter P Abhayaratna
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 47:2357-63. 2006
  5. ncbi Independent association of left atrial function with exercise capacity in patients with preserved ejection fraction
    Kenya Kusunose
    Heart and Vascular Institute, Cleveland Clinic J1 5, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Heart 98:1311-7. 2012
  6. pmc Onset of atrial arrhythmias elicited by autonomic modulation of rabbit sinoatrial node activity: a modeling study
    Mauricio A Muñoz
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Heart Circ Physiol 301:H1974-83. 2011
  7. ncbi An image-based model of atrial muscular architecture: effects of structural anisotropy on electrical activation
    Jichao Zhao
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    Circ Arrhythm Electrophysiol 5:361-70. 2012
  8. ncbi Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response
    Risto Kerkela
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland
    Am J Physiol Regul Integr Comp Physiol 300:R140-9. 2011
  9. ncbi Altered transient outward current in human atrial myocytes of patients with reduced left ventricular function
    J Schreieck
    I Medizinische Klinik, Klinikum rechts der Isar and Klinik für Herzkreislauferkrankungen, Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    J Cardiovasc Electrophysiol 11:180-92. 2000
  10. ncbi Chronic atrial fibrillation ablation impact on endocrine and mechanical cardiac functions
    Frederic Sacher
    Service de Rythmologie, Hopital Cardiologique du Haut Leveque, CHU de Bordeaux Université Bordeaux II, Bordeaux Pessac, France
    Eur Heart J 29:1290-5. 2008

Detail Information

Publications231 found, 100 shown here

  1. ncbi Atrial cell action potential parameter fitting using genetic algorithms
    Z Syed
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada
    Med Biol Eng Comput 43:561-71. 2005
    ..This tool can be useful for determining parameters in new AP models, reproducing specific APs, as well as determining the locus of drug action by examining changes in conductance values...
  2. ncbi Left atrial strain measured by two-dimensional speckle tracking represents a new tool to evaluate left atrial function
    Roberto M Saraiva
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 23:172-80. 2010
    ..To assess its potential value, the authors addressed whether LA epsilon and SR measured in normal subjects correlates with other Doppler echocardiographic parameters that evaluate LA function and left ventricular function...
  3. ncbi Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis
    Chengqun Huang
    Institute of Molecular Medicine and Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0641, USA
    Development 130:6111-9. 2003
    The requirement for atrial function in developing heart is unknown. To address this question, we have generated mice deficient in atrial myosin light chain 2 (MLC2a), a major structural component of the atrial myofibrillar apparatus...
  4. ncbi Left atrial size: physiologic determinants and clinical applications
    Walter P Abhayaratna
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 47:2357-63. 2006
    ..More data are required with respect to the natural history of LA remodeling in disease, the degree of LA modifiability with therapy, and whether regression of LA size translates into improved cardiovascular outcomes...
  5. ncbi Independent association of left atrial function with exercise capacity in patients with preserved ejection fraction
    Kenya Kusunose
    Heart and Vascular Institute, Cleveland Clinic J1 5, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Heart 98:1311-7. 2012
    ..The purpose of this study was to assess the role of LA function in the left ventricular (LV) filling pressure (E/e') response to exercise and exercise tolerance in patients with preserved LV ejection fraction (LVEF)...
  6. pmc Onset of atrial arrhythmias elicited by autonomic modulation of rabbit sinoatrial node activity: a modeling study
    Mauricio A Muñoz
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Heart Circ Physiol 301:H1974-83. 2011
    ..A heterogeneous response to autonomic innervation, a large myocardial load, and an extensive SAN in the intercaval region are required for neurally induced SAN-triggered reentry...
  7. ncbi An image-based model of atrial muscular architecture: effects of structural anisotropy on electrical activation
    Jichao Zhao
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
    Circ Arrhythm Electrophysiol 5:361-70. 2012
    ..The aims of this study were to characterize surface geometry and myofiber architecture throughout the atrial chambers and to investigate the effects of this structure on atrial activation...
  8. ncbi Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response
    Risto Kerkela
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland
    Am J Physiol Regul Integr Comp Physiol 300:R140-9. 2011
    ..In conclusion, our findings identify the local ET-1 system and p38 MAPK as key regulators of load-induced hypertrophic response in isolated rat atria...
  9. ncbi Altered transient outward current in human atrial myocytes of patients with reduced left ventricular function
    J Schreieck
    I Medizinische Klinik, Klinikum rechts der Isar and Klinik für Herzkreislauferkrankungen, Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    J Cardiovasc Electrophysiol 11:180-92. 2000
    ..To define whether differences in atrial electrophysiology already are present in patients with increased susceptibility for atrial fibrillation, we compared patients in sinus rhythm with and without heart failure...
  10. ncbi Chronic atrial fibrillation ablation impact on endocrine and mechanical cardiac functions
    Frederic Sacher
    Service de Rythmologie, Hopital Cardiologique du Haut Leveque, CHU de Bordeaux Université Bordeaux II, Bordeaux Pessac, France
    Eur Heart J 29:1290-5. 2008
    ..Assess the impact of persistent/permanent atrial fibrillation (AF) ablation on endocrine and mechanical cardiac functions...
  11. ncbi Clinical and echocardiographic features influencing recovery of atrial function after cardioversion of atrial fibrillation
    A V Mattioli
    Department of Cardiology, University of Modena, Italy
    Am J Cardiol 82:1368-71. 1998
    ..The recovery of atrial function was influenced by the mode of cardioversion and the size of the left atrium.
  12. ncbi Left atrial function assessed by Doppler echocardiography rather than left atrial volume predicts recurrence in patients with paroxysmal atrial fibrillation
    Ji Hyun Yoon
    Cardiology Division, Heart Center, Gangnam Severance Hospital, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    Clin Cardiol 36:235-40. 2013
    ..Paroxysmal atrial fibrillation (PaAF) may present as a single self-terminating episode of atrial fibrillation (AF) or a more persistent form after sinus conversion. We investigated predictors of recurrence in patients with PaAF...
  13. ncbi Reentry in a morphologically realistic atrial model
    E J Vigmond
    Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA
    J Cardiovasc Electrophysiol 12:1046-54. 2001
    ..4) The openings of the inferior and superior venae cavae form natural anatomic anchors that make reentry easier to initiate by allowing for smaller ectopic beats to induce reentry...
  14. ncbi Is atrial function in Chagas dilated cardiomyopathy more impaired than in idiopathic dilated cardiomyopathy?
    Marcia M Barbosa
    Ecocenter, Hospital Socor, Belo Horizonte, MG, Brazil
    Eur J Echocardiogr 12:643-7. 2011
    b>Atrial function is an important component in overall cardiovascular performance. However, information on atrial function in dilated cardiomyopathy is limited...
  15. ncbi A gradient model of cardiac pacemaker myocytes
    Nigel H Lovell
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, 2052, NSW, Australia
    Prog Biophys Mol Biol 85:301-23. 2004
    ..The gradient model is suitable for developing higher dimensional models of the right atrium, in which action potential heterogeneity within nodal tissue may be readily incorporated...
  16. ncbi Frequency analysis in different types of paroxysmal atrial fibrillation
    Yenn Jiang Lin
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Am Coll Cardiol 47:1401-7. 2006
    ..This study sought to investigate the regional frequency distribution from multiple bi-atrial sites in different types of paroxysmal atrial fibrillation (AF)...
  17. ncbi ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee fo
    Valentin Fuster
    France
    Europace 8:651-745. 2006
  18. ncbi Assessment of regional atrial function in patients with hypertrophic cardiomyopathies using tissue Doppler imaging
    Ragiab Telagh
    Department of Pediatric Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Pediatr Cardiol 29:301-8. 2008
    This study applied tissue Doppler imaging and color tissue Doppler imaging to study atrial function changes in patients with hypertrophic cardiomyopathy (HCM)...
  19. ncbi C-reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation
    Tetsu Watanabe
    First Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Heart Vessels 20:45-9. 2005
    ..Thus, it remains unclear whether CRP and the inflammatory state are contributory to LA remodeling or whether LA remodeling or AF induces elevation in CRP and inflammation...
  20. ncbi Genes and atrial fibrillation: a new look at an old problem
    Diane Fatkin
    Sr Bernice Research Program in Inherited Heart Diseases, Victor Chang Cardiac Research Institute, Darlinghurst, Australia
    Circulation 116:782-92. 2007
  21. ncbi Molecular remodeling of Kv4.3 potassium channels in human atrial fibrillation
    J B Grammer
    Department of Pharmacology, University of Tubingen, Germany
    J Cardiovasc Electrophysiol 11:626-33. 2000
    ..We investigated the effects of AF on the gene expression of the Kv4.3, Kv1.4, and Kv1.5 potassium channel subunits and correlated the findings with the transient outward (Ito) and the sustained outward (Isus or I(Kur)) potassium current...
  22. ncbi Atrial function after epicardial microwave ablation in patients with atrial fibrillation
    Anders Ahlsson
    Department of Cardiothoracic Surgery and Anesthesiology, Orebro University Hospital, Orebro, Sweden
    Scand Cardiovasc J 42:192-201. 2008
    To study epicardial microwave ablation of concomitant atrial fibrillation and its effects on heart rhythm and atrial function during follow-up.
  23. ncbi Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    Eli Berdougo
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 130:6121-9. 2003
    ..These findings are relevant to our understanding of congenital defects in cardiac chamber morphogenesis...
  24. ncbi Two-dimensional echocardiographic methods for assessment of left atrial volume
    Keiji Ujino
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Am J Cardiol 98:1185-8. 2006
    ..In conclusion, our findings suggest that there are systematic differences among existing LA volume methods. Biplane area-length and Simpson's methods compare closely, whereas the prolate-ellipsoid method generally yields smaller volumes...
  25. ncbi Atrial function after surgical and percutaneous closure of atrial septal defect: a strain rate imaging study
    Giovanni Di Salvo
    Physiopathology of the Cardio Respiratory System and Associated Biotechnologies, Second University of Naples, Naples, Italy
    J Am Soc Echocardiogr 18:930-3. 2005
    The effect of operation and the effect of the imposition of an occluding device on atrial function for patients with an atrial septal defect (ASD) has never been studied...
  26. ncbi Electroanatomic analysis of sinus impulse propagation in normal human atria
    Ponti Roberto De
    Department of Cardiology Mater Domini, Castellanza, Italy
    J Cardiovasc Electrophysiol 13:1-10. 2002
    ..In this study, qualitative and quantitative analyses of sinus impulse propagation in both atria were performed by electroanatomic mapping in patients with no organic heart disease who were undergoing an electrophysiologic procedure...
  27. ncbi Determination of normal gender-specific left atrial dimensions by cardiovascular magnetic resonance imaging
    Burkhard Sievers
    Department of Cardiology and Angiology, Marienhospital, University of Bochum, Herne, Germany
    J Cardiovasc Magn Reson 7:677-83. 2005
    ..We aimed to establish normal values for LAEDD using CMR and a fast gradient-echo sequence with steady-state free precession (SSFP)...
  28. ncbi Improvement of atrial function and atrial reverse remodeling after cardiac resynchronization therapy for heart failure
    Cheuk Man Yu
    Li Ka Shing Institute of Health Sciences, Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital and Institute of Vascular Medicine, S H Ho Cardiovascular and Stroke Centre, Shatin, NT, Hong Kong, China
    J Am Coll Cardiol 50:778-85. 2007
    We sought to examine whether cardiac resynchronization therapy (CRT) improves atrial function and induces atrial reverse remodeling.
  29. ncbi Cardiac magnetic resonance imaging assessment of regional and global left atrial function before and after catheter ablation for atrial fibrillation
    David Nori
    Department of Cardiovascular Medicine, Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI, 48073, USA
    J Interv Card Electrophysiol 26:109-17. 2009
    ..We sought to evaluate the effect that AF ablation procedures has on global and regional wall motion as assessed by cardiovascular magnetic resonance imaging (MRI)...
  30. ncbi Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation
    Antony J Workman
    Section of Cardiology, Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    Cardiovasc Res 59:593-602. 2003
    ....
  31. ncbi Restoration of atrial contractility after surgical cryoablation: clinical, electrical and mechanical results
    Guillermo Reyes
    Department of Cardiovascular Surgery, Hospital Universitario La Princesa, C Diego de Leon 62, 28006 Madrid, Spain
    Interact Cardiovasc Thorac Surg 9:609-12. 2009
    ..Cryoablation for AF is an effective technique to recover electrocardiographic SR while being able to recover atrial contraction effectiveness...
  32. ncbi Strain rate evaluation of phasic atrial function in hypertension
    S Eshoo
    Department of Cardiology, Westmead Hospital, Westmead, 2145 NSW, Australia
    Heart 95:1184-91. 2009
    Strain (SI) and strain rate (SR) measure regional myocardial deformation and may be a new technique to assess phasic atrial function.
  33. ncbi High-density mapping of left atrial endocardial activation during sinus rhythm and coronary sinus pacing in patients with paroxysmal atrial fibrillation
    Timothy R Betts
    Wessex Cardiac Centre, Southampton General Hospital, Southampton, United Kingdom
    J Cardiovasc Electrophysiol 15:1111-7. 2004
    ..This study was designed to record global high-density maps of left atrial endocardial activation during sinus rhythm and coronary sinus pacing...
  34. ncbi Atrial fibrillation surgery simplified with cryoablation to improve left atrial function
    J W Lee
    Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan, Seoul, Korea
    Ann Thorac Surg 72:1479-83. 2001
    ..The Maze procedure restores atrial fibrillation to normal sinus rhythm. However, concurrent left atrial functional recovery is not always achieved. To address this limitation, a modification using linear cryoablation is described...
  35. ncbi Characterization of left atrial activation in the intact human heart
    Vias Markides
    St Mary s Hospital, Imperial College, London, UK
    Circulation 107:733-9. 2003
    ..The patterns of activation of the human left atrium (LA), how they relate to atrial myocardial architecture, and their role in arrhythmogenesis remain largely unknown...
  36. ncbi The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation
    A J Workman
    University Department of Medical Cardiology, Royal Infirmary, 10 Alexandra Parade, G31 2ER, Glasgow, UK
    Cardiovasc Res 52:226-35. 2001
    ..To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes...
  37. ncbi Mechanisms of atrial remodeling and clinical relevance
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
    Curr Opin Cardiol 20:21-5. 2005
    ..This paper reviews recent progress in understanding atrial remodeling, as well as the consequent clinical insights into atrial fibrillation pathophysiology and treatment...
  38. ncbi Mechanisms of perpetuation of atrial fibrillation in chronically dilated atria
    Jens Eckstein
    Department of Physiology, Cardiovascular Research Institute, University Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Prog Biophys Mol Biol 97:435-51. 2008
    ..This article reviews data suggesting a role of endo-epicardial dissociation in dilated and fibrillating atria, for the self-perpetuating nature of AF as well as its possible implications for therapeutic interventions...
  39. ncbi Sequence of electrical activation, atrial remodelling and atrial fibrillation in patients with nodal re-entrant tachycardia
    Radosław Lenarczyk
    First Department of Cardiology, Silesian Medical School, Silesian Center for Heart Diseases, Zabrze, Poland
    Acta Cardiol 62:599-606. 2007
    ....
  40. ncbi Arrhythmogenic difference between the left and right atria during rapid atrial activation in a canine model of atrial fibrillation
    Shinichi Niwano
    Department of Cardio angiology, Kitasato University School of Medicine, Sagamihara, Japan
    Circ J 71:1629-35. 2007
    ..Continuous rapid atrial stimulation causes atrial remodeling, but little is known about the difference in the arrhythmogenicity of the left (LA) and right atria (RA)...
  41. ncbi Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans
    Prashanthan Sanders
    Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
    Circulation 108:1461-8. 2003
    ..However, the electrophysiological substrate for AF in humans with CHF remains unknown. We evaluated the electrophysiological and electroanatomic characteristics of the atria in patients with CHF...
  42. ncbi Thyroid hormone regulates mRNA expression and currents of ion channels in rat atrium
    Hiroshi Watanabe
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, 1 754 Asahimachidori, Niigata, Japan
    Biochem Biophys Res Commun 308:439-44. 2003
    ..In conclusion, T3 increased the outward currents and decreased the inward currents. The resultant changes of ionic currents shortened APD, providing a substrate for atrial fibrillation...
  43. ncbi A novel approach to restore atrial function after the maze procedure in patients with an enlarged left atrium
    Akira Marui
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Eur J Cardiothorac Surg 32:308-12. 2007
    ..However, it is unknown whether the procedures can also restore effective atrial function of the enlarged LA with over-stretched myocardium.
  44. ncbi Basic mechanisms of atrial fibrillation
    David R Van Wagoner
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cleve Clin J Med 70:S2-5. 2003
  45. ncbi Effect of 60 minutes of rapid atrial pacing on atrial action potential duration in the in-situ canine heart
    Ichiro Watanabe
    The Second Department of Medicine, Nihon University School of Medicine, 30 1 Oyaguchi Kami, Itabashi ku, Tokyo 173 8610, Japan
    J Interv Card Electrophysiol 8:165-71. 2003
    ....
  46. ncbi Atrial stunning: determinants and cellular mechanisms
    Ijaz A Khan
    Division of Cardiology, Creighton University School of Medicine, Omaha, Neb 68131 2044, USA
    Am Heart J 145:787-94. 2003
    ..Atrial stunning is a transient depression of atrial and atrial-appendage mechanical function after successful cardioversion of atrial fibrillation compared with its precardioversion state...
  47. pmc Ionic mechanisms underlying region-specific remodeling of rabbit atrial action potentials caused by intermittent burst stimulation
    Wen Dun
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Heart Rhythm 4:499-507. 2007
    ..In isolated rabbit right or left atrial preparations, a 3-hour intermittent burst pacing protocol shortens action potential duration (APD) in CS and PV, but not in sinus node (SN) and left Bachmann bundle (BB) regions...
  48. ncbi Impedance monitoring during catheter ablation of atrial fibrillation
    Marmar Vaseghi
    UCLA Cardiac Arrhythmia Center, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Heart Rhythm 2:914-20. 2005
    ..A sudden decrease in impedance as the catheter is moved from the vein into the left atrium (LA) has been used to define the pulmonary vein-LA transition during ablation procedures...
  49. ncbi Atrial electrophysiology and mechanisms of atrial fibrillation
    Stanley Nattel
    Research Center, Montreal Heart Institute, Montreal, Canada
    J Cardiovasc Pharmacol Ther 8:S5-11. 2003
    ..It is hoped that this improved mechanistic understanding will lead to the development of improved therapeutic options...
  50. ncbi Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity
    Alexander Burashnikov
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 107:2355-60. 2003
    ....
  51. ncbi Experimental and clinical AF mechanisms: bridging the divide
    JOSE JALIFE
    SUNY Upstate Medical University, 766 Irving Avenue, Syracuse, NY 13210, USA
    J Interv Card Electrophysiol 9:85-92. 2003
    ....
  52. ncbi Simultaneous right atrioventricular pacing: a novel model to study atrial remodeling and fibrillation in the setting of heart failure
    Gabriel Laurent
    Division of Cardiology, University of Toronto and Terrence Donnelly Cardiovascular Laboratories, St Michael s Hospital, Ontario, Canada
    J Card Fail 14:254-62. 2008
    ..Atrial remodeling is a key substrate for the development of AF in HF. However, experimental models that study AF in the setting of HF have important limitations. We evaluated a new dog model of atrial remodeling and AF...
  53. ncbi Temporal patterns of progression and regression of electrical and mechanical remodeling of the atrium
    Osamu Kinebuchi
    Cardiology Division, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, 160 8582 Tokyo, Japan
    Int J Cardiol 98:91-8. 2005
    ..We evaluated serial changes of electrical and mechanical parameters of atrial remodeling in dogs subjected to rapid atrial pacing...
  54. ncbi Age- and sex-related atrial electrophysiologic and structural changes
    Xiao Ke Liu
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 94:373-5. 2004
    ..It was concluded that LA size is greater in the elderly and in men, which may increase their risk for AF...
  55. ncbi Electrophysiologic and electroanatomic changes in the human atrium associated with age
    Peter M Kistler
    Department of Cardiology, Royal Melbourne Hospital, Australia
    J Am Coll Cardiol 44:109-16. 2004
    ..The purpose of this study was to characterize the pattern of atrial remodeling seen with human aging...
  56. ncbi On the atrial response to focal discharges in man
    Hemanth Ramanna
    Heart Lung Center Utrecht, University Medical Center, Utrecht, The Netherlands
    J Cardiovasc Electrophysiol 15:629-36. 2004
    ....
  57. ncbi Atrial ablation for the surgical treatment of atrial fibrillation: principles and limitations
    Joao Q Melo
    SantaCruz Hospital, Carnaxide, Portugal
    J Card Surg 19:207-10. 2004
    ..Finally, atrial contractility is addressed, and the authors conclude that the ideal procedure will achieve a balance between conversion to normal sinus rhythm and the preservation of atrial contractility...
  58. pmc Diadenosine-5-phosphate exerts A1-receptor-mediated proarrhythmic effects in rabbit atrial myocardium
    B Brandts
    Department of Cardiology and Angiology, University Hospital Heme, Ruhr University Bochum, Germany
    Br J Pharmacol 139:1265-72. 2003
    ..An influence on atrial electrophysiology or a facilitation of atrial fibrillation under conditions resulting in increased interstitial Ap(5)A concentrations might be of physiological/pathophysiological relevance...
  59. ncbi Electrophysiological characterization of cardiac veins in humans
    David A Cesario
    UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine at UCLA, Los Angeles CA
    J Interv Card Electrophysiol 10:241-7. 2004
    ..The purpose of this study was to evaluate the electrical activity of the coronary sinus (CS), great cardiac vein (GCV) and related structures, such as the Vein of Marshall (VOM)...
  60. ncbi [Molecular basis of remodelling in atrial fibrillation]
    D Dobrev
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der Technischen Universität Dresden
    Dtsch Med Wochenschr 129:827-30. 2004
  61. ncbi Map-guided surgery for atrial fibrillation
    Takashi Nitta
    Department of Cardiothoracic Surgery, Nippon Medical School, Tokyo, Japan
    J Thorac Cardiovasc Surg 129:291-9. 2005
    ..We sought to determine whether intraoperative mapping is beneficial for the surgical treatment of atrial fibrillation...
  62. ncbi Permanent left atrial pacing: a 2-year follow-up of coronary sinus leads
    Intisar Mirza
    John Radcliffe Hospital Oxford, Maidstone General Hospital Kent Guy s and St Thomas Hospital London, The United Kingdom
    Pacing Clin Electrophysiol 27:314-7. 2004
    ..The trends seen at both sites for chronic changes in pacing characteristics are analogous to those described for endocardial leads at other sites...
  63. ncbi Concurrent multiple left atrial focal activations with fibrillatory conduction and right atrial focal or reentrant activation as the mechanism in atrial fibrillation
    Takashi Nitta
    Department of Cardiothoracic Surgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Thorac Cardiovasc Surg 127:770-8. 2004
    ..We examined the atrial activation during atrial fibrillation to validate the rationale behind simplified surgical procedures...
  64. ncbi Pilot study: Noninvasive monitoring of oral flecainide's effects on atrial electrophysiology during persistent human atrial fibrillation using the surface electrocardiogram
    Daniela Husser
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    Ann Noninvasive Electrocardiol 10:206-10. 2005
    ....
  65. ncbi Atrial septal pacing to resynchronize atrial contraction and improve atrial transport function
    Hidekazu Miyazaki
    Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    J Cardiol 45:239-46. 2005
    ..This study examined whether this pacing method will lead to resynchronization of atrial contraction and its benefit on hemodynamic function can be maintained for 24 months...
  66. ncbi Hemodynamic effects of alternative atrial pacing sites in patients with paroxysmal atrial fibrillation
    Alicja Dabrowska-Kugacka
    II Dept of Cardiology, Medical University of Gdansk, Kieturakisa 1, 80 742 Gdansk, Poland
    Pacing Clin Electrophysiol 26:278-83. 2003
    ....
  67. ncbi Atrial fibrillation: basic mechanisms, remodeling and triggers
    Akiko Shiroshita-Takeshita
    Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    J Interv Card Electrophysiol 13:181-93. 2005
  68. ncbi Congenital atrial standstill associated with coinheritance of a novel SCN5A mutation and connexin 40 polymorphisms
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Heart Rhythm 2:1128-34. 2005
    ..Incomplete penetrance observed in atrial standstill has been attributed in part to the digenic inheritance of polymorphisms in the atrial-specific gap junction connexin 40 (Cx40) in conjunction with an SCN5A mutation...
  69. ncbi Electrical, contractile and structural remodeling during atrial fibrillation
    Maurits Allessie
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 54:230-46. 2002
    ..The recent finding that AF itself produces changes in atrial function and structure has provided a possible explanation for the progressive nature of this arrhythmia...
  70. ncbi [Morphological remodeling in atrial fibrillation]
    Andreas Goette
    Klinik fur Kardiologie, Angiologie und Pneumologie, Otto von Guericke Universitätsklinik, Magdeburg
    Herz 31:101-7; quiz 142-3. 2006
    ..This highly interesting methodology may be helpful to restore electrical conduction in fibrotic cardiac tissue...
  71. ncbi Effect of acute atrial fibrillation on phasic coronary blood flow pattern and flow reserve in humans
    G E Kochiadakis
    Cardiology Department, University Hospital of Heraklion, Crete, Greece
    Eur Heart J 23:734-41. 2002
    ..To assess the effect of experimentally induced atrial fibrillation on coronary flow in humans...
  72. ncbi Importance of right and left atrial dilation and linear ablation for perpetuation of sustained atrial fibrillation
    Markus Zarse
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    J Cardiovasc Electrophysiol 13:164-71. 2002
    ....
  73. ncbi Age-dependent atrial remodeling induced by recombinant human interleukin-11: implications for atrial flutter/fibrillation
    Jiang Xu
    MCP Hahnemann University, Philadelphia, Pennsylvania 19102 1192, USA
    J Cardiovasc Pharmacol 39:435-40. 2002
    ..It was concluded that rhIL-11 induces age-dependent atrial remodeling manifested by atrial stretch and reduced atrial refractoriness, which favor AF. Na retention is the most likely mechanism underlying this effect of rhIL-11...
  74. ncbi Posterior left atrial-esophageal relationship throughout the cardiac cycle
    Jasbir Sra
    Electrophysiology Laboratories, Aurora Sinai St Luke s Medical Centers, University of Wisconsin School of Medicine and Public Health Milwaukee Clinical Campus, Milwaukee, Wisconsin, USA
    J Interv Card Electrophysiol 16:73-80. 2006
    ..Radiofrequency energy delivered throughout the cardiac cycle has the potential to cause thermal injury to the esophagus if the anatomical relationship between the posterior left atrium and the esophagus changes during cardiac motion...
  75. ncbi Electrical remodeling in atrial fibrillation
    Dobromir Dobrev
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Herz 31:108-12; quiz 142-3. 2006
    ....
  76. ncbi Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: implications for development of atrial fibrillation
    Peter M Kistler
    Department of Cardiology, Royal Melbourne Hospital, Melbourne 3050, Australia
    Eur Heart J 27:3045-56. 2006
    ..We aimed to characterize the atrial electrical and structural changes in a chronic ovine model of EBP after prenatal corticosteroid exposure...
  77. ncbi Heterogeneous three-dimensional anatomical and electrophysiological model of human atria
    Gunnar Seemann
    Institute of Biomedical Engineering, University Karlsruhe TH, Kaiserstrasse 12, 76128 Karlsruhe, Germany
    Philos Trans A Math Phys Eng Sci 364:1465-81. 2006
    ..Repolarization is more homogeneous than excitation due to the heterogeneous distribution of electrophysiological properties and hence the action potential duration...
  78. ncbi A computer model of human atria with reasonable computation load and realistic anatomical properties
    O Blanc
    Signal Processing Laboratory, Swiss Federal Institute of Technology, Lausanne
    IEEE Trans Biomed Eng 48:1229-37. 2001
    ..Such details are difficult or impossible to study in humans. This model will serve us as a tool to evaluate the impact of new therapeutic strategies and to improve them...
  79. ncbi Mechanisms of cardiac arrhythmias: focus on atrial fibrillation
    M R Rosen
    Departments of Pharmacology and Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Gend Specif Med 4:37-47. 2001
    ..He emphasizes the changes that occur in the atrium as a result of rapid rate and/or fibrillation and the interdependence of AF and changes in myocardial structure...
  80. ncbi Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation
    Y Shi
    Department of Medicine, Montreal Heart Institute and University of Montreal, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8, Canada
    Cardiovasc Res 52:217-25. 2001
    ..Whereas in ATR, electrophysiological remodeling is of prime importance in AF promotion, structural remodeling (as reflected in changes in atrial size and contraction) appears much more important in HF-induced AF...
  81. ncbi Changes in activation sequence of embryonic chick atria correlate with developing myocardial architecture
    David Sedmera
    Laboratory of Cardiovascular Morphogenesis, Institute of Animal Physiology and Genetics, Videnska 1083, 142 20 Prague 4 Krc, Czech Republic
    Am J Physiol Heart Circ Physiol 291:H1646-52. 2006
    ..The purpose of these preferential pathways appears to be to assure synchronous atrial activation and contraction rather than rapid impulse conduction between the sinoatrial and atrioventricular nodes...
  82. ncbi Mechanoelectric feedback leads to conduction slowing and block in acutely dilated atria: a modeling study of cardiac electromechanics
    Nico H L Kuijpers
    Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands
    Am J Physiol Heart Circ Physiol 292:H2832-53. 2007
    ..Our observations are in agreement with experimental results and explain the large differences in intra-atrial conduction, as well as the increased inducibility of atrial fibrillation in acutely dilated atria...
  83. ncbi Future concepts in P wave morphological analyses
    Polychronis E Dilaveris
    Department of Cardiology, Hippokration Hospital, Athens, Greece
    Card Electrophysiol Rev 6:221-4. 2002
    ..The feasibility of the surface ECG to detect the presence of an abnormal electrophysiological substrate in the atrial myocardium as well as to localize ectopic atrial rhythms will be enhanced by use of P wave morphological analysis...
  84. ncbi Pacing-induced spontaneous activity in myocardial sleeves of pulmonary veins after treatment with ryanodine
    Haruo Honjo
    Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    Circulation 107:1937-43. 2003
    ....
  85. ncbi Interatrial electrical connections: the precise location and preferential conduction
    Shun ichiro Sakamoto
    Department of Cardiothoracic Surgery, Nippon Medical School, Tokyo, Japan
    J Cardiovasc Electrophysiol 16:1077-86. 2005
    ..However, the number, location, and preferential connections of the interatrial conduction related to the site of activation have not been examined yet...
  86. ncbi Molecular mechanisms of remodeling in human atrial fibrillation
    Bianca J J M Brundel
    Department of Radiation and Stress Cell Biology, University of Groningen, A Deusinglaan 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Cardiovasc Res 54:315-24. 2002
    ..However, such early protection occurs at the expense of electrophysiological changes that promote the long-term maintenance of AF...
  87. ncbi Electrical and structural remodeling: role in the genesis and maintenance of atrial fibrillation
    Bas A Schoonderwoerd
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, RB Groningen, The Netherlands
    Prog Cardiovasc Dis 48:153-68. 2005
    ..Both lead to changes in atrial function and structure, an array of processes known as atrial remodeling...
  88. ncbi Heterogeneous pulmonary vein myocardial cell repolarization implications for reentry and triggered activity
    Yasushi Miyauchi
    Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Heart Rhythm 2:1339-45. 2005
    ..However, systematic single-cell microelectrode recordings from different regions in intact PV-atrial tissues are lacking...
  89. ncbi Electrophysiologic actions of dl-sotalol in patients with persistent atrial fibrillation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, China
    J Am Coll Cardiol 40:2150-5. 2002
    ..We sought to determine the electrophysiologic actions of sotalol in the remodeled atrium of humans...
  90. ncbi Effect of electrical and structural remodeling on spatiotemporal organization in acute and persistent atrial fibrillation
    Joseph G Akar
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Cardiovasc Electrophysiol 13:1027-34. 2002
    ..Atrial fibrillation (AF) may originate from discrete sites of periodic activity. We studied the effect of structural and electrical remodeling on spatiotemporal organization in acute and persistent AF...
  91. ncbi Atrial natriuretic peptide has dose-dependent, autonomically mediated effects on atrial refractoriness and repolarization in anesthetized dogs
    Bruce S Stambler
    Department of Medicine, McGuire Veterans Affairs Medical Center, Medical College of Virginia, Richmond, Virginia, USA
    J Cardiovasc Electrophysiol 16:1341-7. 2005
    ....
  92. ncbi Driver regions in atrial fibrillation associated with congestive heart failure: where are they, and what are they telling us?
    Stanley Nattel
    J Cardiovasc Electrophysiol 16:1359-61. 2005
  93. ncbi Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 69:865-75. 2006
    ..This study evaluated the efficacy of anti-inflammatory and calcineurin-inhibitory drugs on promotion of atrial fibrillation by atrial tachycardia-induced remodeling in dogs...
  94. ncbi Internal atrial shock delivery by standard diagnostic electrophysiology catheters in goats: effects on atrial electrogram amplitude and tissue architecture
    M C E F Wijffels
    Department of Cardiology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Europace 9:203-7. 2007
    ..In this study, we evaluated the effects of atrial shock delivered via diagnostic electrophysiology catheters...
  95. ncbi [Assessment of right atrial and ventricular function by radionuclide ventriculography using continuous infusion of 81mKr]
    T Shogase
    Department of Cardiovascular Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
    Hokkaido Igaku Zasshi 66:122-34. 1991
    ..4) To assess the right atrial function, right atrial volume curve was measured in 10 normal volunteers, 32 patients with OMI and 4 patients with PPH...
  96. ncbi [Pulmonary wedge pressure and heart frequency measurements during standardized treadmill exercise for extension of left atrial function diagnosis in warmblood horses]
    H Gehlen
    Klinik fur Pferde, Tierrztliche Hochschule Hannover
    Dtsch Tierarztl Wochenschr 110:280-5. 2003
    ..Between left atrial size and pulmonary wedge pressure a statistical weak correlation could be observed up to a treadmill velocity of 6 and 7 m/s...
  97. ncbi Maternal diastolic dysfunction and left ventricular geometry in gestational hypertension
    H Valensise
    Department of Obstetrics and Gynecology and the School of Cardiology, Semeiology, Tor Vergata University, Rome, Italy
    Hypertension 37:1209-15. 2001
    ..01). Left atrial function and cardiac output were significantly lower in gestational hypertension (P<0.01)...
  98. ncbi Assessment of systolic and diastolic left ventricular and left atrial function using vector velocity imaging in Takotsubo cardiomyopathy
    Manjula V Burri
    Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Echocardiography 25:1138-44. 2008
    ..Longitudinal LA dysfunction may also be present...
  99. ncbi Fate of left atrial function as determined by real-time three-dimensional echocardiography study after radiofrequency catheter ablation for the treatment of atrial fibrillation
    Victoria Delgado
    Cardiology Department, Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Cardiol 101:1285-90. 2008
    ....
  100. ncbi Left atrial function: bridge to central and hormonal determinants of exercise capacity in patients with chronic heart failure
    M Ceresa
    Istituto Scientifico di Montescano, Fondazione Salvatore Maugeri, IRCCS, Italy, Pavia
    Monaldi Arch Chest Dis 58:87-94. 2002
    ..We performed this study to investigate the relationship between exercise capacity and diastolic and systolic left atrium function in patients with chronic heart failure...
  101. ncbi Hemodynamic change in transmitral gradient during Valsalva maneuver and its relation with left atrial function, functional capacity, and pulmonary artery pressure in patients with mitral stenosis in sinus rhythm
    Ozcan Ozeke
    Yuksek Ihtisas Hospital, Department of Cardiology, Ankara, Turkey
    J Am Soc Echocardiogr 19:1245-50. 2006
    ..between the degree of the hemodynamic changes in transmitral gradient (TG) in response to Valsalva maneuver and functional status, systolic pulmonary artery pressure, and left atrial function in patients with MS in sinus rhythm.

Research Grants26

  1. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    ..Aim III will test the hypothesis that alterations in SLN to SERCA ratio will affect atrial function and predispose the atria to develop atrial pathology including atrial fibrillation upon increased load or ..
  2. Impact of Atrial Fibrillation and Surgical Ablation on Atrial Function
    JASON OWEN ROBERTSON; Fiscal Year: 2012
    ..The second part of this proposal will test the effect of each of the individual CM IV lesion sets on atrial function in the same swine model of persistent AF...
  3. The Contribution of Melanocyte-like Cells to Atrial Function and Development
    Vickas V Patel; Fiscal Year: 2013
    ....
  4. SURGICAL TREATMENT OF CARDIAC ARRHYTHMIAS
    Ralph J Damiano; Fiscal Year: 2013
    ..To develop accurate techniques to evaluate the consequences of AF and surgical ablation on left and right atrial function, both experimentally and clinically...
  5. Aging and atrial fibrillation: the role of atrial myocyte cytosolic Ca2+ dynamics
    Matthew Betzenhauser; Fiscal Year: 2012
    ..This suggests that age-dependent modifications of atrial function can cause AF...
  6. ELECTROPHYSIOLOGY OF RIGHT ATRIAL PACEMAKERS
    STEPHEN LIPSIUS; Fiscal Year: 2000
    ..Although cholinergic stimulation exerts antiarrhythmic effects on atrial function, it also generates atrial dysrhythmias, the mechanisms of which are not known...
  7. ATRIOVENTRICULAR INTERACTIONS RELATED TO CARDIAC SURGERY
    Peter Smith; Fiscal Year: 1992
    ..Detailed analysis of left atrial function will be accomplished using ultrasonic dimension transducers, high fidelity intra-cavitary pressure ..
  8. Physiological impacts of atrial fibrillation surgery
    ROCHUS VOELLER; Fiscal Year: 2006
    ..treatments of atrial fibrillation (AF) such as the Maze and Radial procedures is the preservation of normal atrial function. However, knowledge of normal and abnormal atrial function is sparse, and the techniques to accurately ..
  9. The Pathophysiology of T-wave Alternans
    Sanjiv Narayan; Fiscal Year: 2005
    ..This structured approach will ensure the successful completion of this project and, in this way, the development of the applicant into an independent clinician-investigator. ..
  10. Oxidative Stress and Atrial Fibrillation
    DAVID VAN WAGONER; Fiscal Year: 2004
    ..stress modulates the activity of several ion channels (Ca, K, and ryanodine receptor) important for normal atrial function. In preliminary studies, we have demonstrated that rapid pacing of canine atria results in increased ..
  11. SYMPATHETIC FUNCTION IN DIABETES
    David C Randall; Fiscal Year: 2010
    ..parasympathetic dysfunction) and easier and less expensive to obtain. The results of these experiments will thereby help develop better clinical approaches to the control and management of diabetic autonomic neuropathy. ..
  12. CA2+-MEDIATED MECHANISMS OF ATRIAL PACEMAKER ACTIVITY
    STEPHEN LIPSIUS; Fiscal Year: 2004
    ..It is expected that the results gained from these studies will provide fundamental insight into the cellular mechanisms governing normal and abnormal atrial pacemaker function. ..
  13. Beta-Adrenergic Receptor Function in Atrial Myocytes
    STEPHEN LIPSIUS; Fiscal Year: 2008
    ..abstract_text> ..
  14. Acuson Sequoia Ultrasonograph
    Brian Hoit; Fiscal Year: 2003
    ....
  15. REGULATION OF CALCIUM CURRENT IN ATRIAL CELLS
    RONALD JOYNER; Fiscal Year: 2002
    ..5) The maintained responsiveness of adult atrial ICa,L to cGMP compared to ventricular cells is a consequence of 2 phosphorylation sites, which as phosphorylated independently by PKG and PKA. ..
  16. Adiponectin and Cardiovascular Disease in the CKiD Children
    Mark Mitsnefes; Fiscal Year: 2009
    ....
  17. Arterial baroreceptor unloading causes hypertension
    TERRY THRASHER; Fiscal Year: 2005
    ..These studies will provide a new framework for understanding the development and maintenance of hypertension. ..
  18. Calcium Current in Human Atrial Myocytes
    RONALD JOYNER; Fiscal Year: 2008
    ..Previous animal studies have indicated various developmental changes in cardiac cells. We will specifically study human postnatal developmental changes in Ito regulation of ICa and intracellular Ca2+ transients. ..
  19. Altered Myocardial Fatty Acid Metabolism in Obesity
    Linda Peterson; Fiscal Year: 2007
    ..Such information will form the basis for more targeted studies designed to elucidate the mechanisms responsible for these abnormalities and potentially result in significant clinical benefit for humans with AO. ..
  20. Cardiac disease in children with chronic renal failure
    Mark Mitsnefes; Fiscal Year: 2006
    ..Thus, the long-term goal will be to decrease the incidence and prevalence of cardiovascular disease in young adults who developed chronic renal disease during childhood. ..
  21. Cardiac Arrhythmia Mechanisms
    JOSE JALIFE; Fiscal Year: 2005
    ....
  22. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2008
    ..4) To study the properties and repolarization-dependent mechanisms of arrhythmias in the remodeled myocardium post myocardial infarction. ..
  23. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2007
    ..abstract_text> ..
  24. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  25. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  26. Molecular Mechanisms of Ventricular Fibrillation
    JOSE JALIFE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..