cardiovascular physiology


Summary: Functions and activities of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.

Top Publications

  1. ncbi The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
    Gavin Y Oudit
    Heart and Stroke Richard Lewar Centre of Excellence, Departments of Medicine and Physiology, University of Toronto, Room 68, 150 College Street, Fitzgerald Building, Toronto, Ont, M5S 3E2, Canada
    J Mol Cell Cardiol 37:449-71. 2004
  2. ncbi Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology
    Donald E Ingber
    Vascular Biology Program, Departments of Pathology and Surgery, Harvard Medical School and Children s Hospital, Boston, Mass 02115, USA
    Circ Res 91:877-87. 2002
  3. ncbi A model for educational simulation of infant cardiovascular physiology
    Jane A Goodwin
    Nemours Children s Clinic Jacksonville, 807 Children s Way, Jacksonville, FL 32207, USA
    Anesth Analg 99:1655-64, table of contents. 2004
  4. ncbi The role of ACE2 in cardiovascular physiology
    Gavin Y Oudit
    Department of Medical Biophysics and Richard Lewar Heart and Stroke Center of Excellence, University of Toronto, Toronto, Canada
    Trends Cardiovasc Med 13:93-101. 2003
  5. ncbi Cardiovascular physiology and sleep
    Narayana S Murali
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Front Biosci 8:s636-52. 2003
  6. ncbi Rho kinases in cardiovascular physiology and pathophysiology
    Gervaise Loirand
    INSERM U 533 Institut du Thorax, Faculte des Sciences, Nantes, France
    Circ Res 98:322-34. 2006
  7. ncbi Cardiovascular physiology-changes with aging
    Melvin D Cheitlin
    University of California at San Francisco, Former Chief of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
    Am J Geriatr Cardiol 12:9-13. 2003
  8. ncbi The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology
    Vijay Sharma
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada
    Curr Vasc Pharmacol 3:169-80. 2005
  9. ncbi Cardiovascular physiology: simulation of steady state and transient phenomena by using the equivalent electronic circuit
    M Rupnik
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, 1104, Ljubljana, Slovenia
    Comput Methods Programs Biomed 67:1-12. 2002
  10. ncbi Simulation of some short-term control mechanisms in cardiovascular physiology
    T Podnar
    Faculty of Medicine, University Hospital of Pediatrics, University of Ljubljana, 1104 Ljubljana, Slovenia
    Comput Biol Med 34:35-49. 2004

Detail Information

Publications244 found, 100 shown here

  1. ncbi The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
    Gavin Y Oudit
    Heart and Stroke Richard Lewar Centre of Excellence, Departments of Medicine and Physiology, University of Toronto, Room 68, 150 College Street, Fitzgerald Building, Toronto, Ont, M5S 3E2, Canada
    J Mol Cell Cardiol 37:449-71. 2004
    ..In this review, we discuss the biochemistry and molecular biology of PI3K (class I isoforms) and PTEN and their critical role in cardiovascular physiology and diseases.
  2. ncbi Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology
    Donald E Ingber
    Vascular Biology Program, Departments of Pathology and Surgery, Harvard Medical School and Children s Hospital, Boston, Mass 02115, USA
    Circ Res 91:877-87. 2002
    ..Thus, the mechanism by which cells perform mechanochemical transduction and the implications of these findings for morphogenetic control are discussed in the wider context of vascular development and cardiovascular physiology.
  3. ncbi A model for educational simulation of infant cardiovascular physiology
    Jane A Goodwin
    Nemours Children s Clinic Jacksonville, 807 Children s Way, Jacksonville, FL 32207, USA
    Anesth Analg 99:1655-64, table of contents. 2004
    ..This infant cardiovascular model can form the basis for screen-based educational simulations. The model is also an essential step in attaining a full-body, model-driven infant simulator...
  4. ncbi The role of ACE2 in cardiovascular physiology
    Gavin Y Oudit
    Department of Medical Biophysics and Richard Lewar Heart and Stroke Center of Excellence, University of Toronto, Toronto, Canada
    Trends Cardiovasc Med 13:93-101. 2003
  5. ncbi Cardiovascular physiology and sleep
    Narayana S Murali
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Front Biosci 8:s636-52. 2003
    ..sensitivity (BRS) (11-16), and intraneural measurement of sympathetic nerve traffic to muscle (MSNA) (17-22) and skin (SSNA) (23-24) have further advanced our understanding of mechanisms linking sleep and cardiovascular physiology.
  6. ncbi Rho kinases in cardiovascular physiology and pathophysiology
    Gervaise Loirand
    INSERM U 533 Institut du Thorax, Faculte des Sciences, Nantes, France
    Circ Res 98:322-34. 2006
    ..This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology.
  7. ncbi Cardiovascular physiology-changes with aging
    Melvin D Cheitlin
    University of California at San Francisco, Former Chief of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
    Am J Geriatr Cardiol 12:9-13. 2003
    With aging there are changes in the cardiovascular system, which result in alterations in cardiovascular physiology. The changes in cardiovascular physiology must be differentiated from the effects of pathology, such as coronary artery ..
  8. ncbi The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology
    Vijay Sharma
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada
    Curr Vasc Pharmacol 3:169-80. 2005
    ..The evidence for and against these effects as well as their pathophysiological significance in obesity hypertension, heart failure, atherosclerosis and thrombosis are discussed...
  9. ncbi Cardiovascular physiology: simulation of steady state and transient phenomena by using the equivalent electronic circuit
    M Rupnik
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, 1104, Ljubljana, Slovenia
    Comput Methods Programs Biomed 67:1-12. 2002
    ..The described approach has been found a useful tool in teaching physiology and pathophysiology for postgraduate medical students...
  10. ncbi Simulation of some short-term control mechanisms in cardiovascular physiology
    T Podnar
    Faculty of Medicine, University Hospital of Pediatrics, University of Ljubljana, 1104 Ljubljana, Slovenia
    Comput Biol Med 34:35-49. 2004
    The equivalent electronic circuit, developed to simulate cardiovascular physiology, is upgraded to incorporate negative feedback loops...
  11. ncbi The influence of cardiovascular physiology on dose/pharmacokinetic and pharmacokinetic/pharmacodynamic relationships
    Pietro Fagiolino
    Pharmacology and Biopharmaceutics, Faculty of Chemistry, University of the Republic of Uruguay, Montevideo, Uruguay
    Clin Pharmacokinet 45:433-48. 2006
    ..Furthermore, the administration of cardiovascular active drugs might reverse the chronological sequence between pharmacokinetic and pharmacodynamic responses, since they could modify blood flow distribution...
  12. pmc Chronoecological health watch of arterial stiffness and neuro-cardio-pulmonary function in elderly community at high altitude (3524 m), compared with Japanese town
    K Otsuka
    Department of Medicine, Medical Center East, Tokyo Women s Medical University, Nishiogu 2 1 10, Arakawa, Tokyo 116 8567, Japan
    Biomed Pharmacother 59:S58-67. 2005
  13. ncbi Understanding cardiovascular physiology in zebrafish and Xenopus larvae: the use of microtechniques
    Thorsten Schwerte
    University of Innsbruck, Institute for Zoology and Limnology, Techniker Str 25, A 6020 Innsbruck, Austria
    Comp Biochem Physiol A Mol Integr Physiol 135:131-45. 2003
    ..Here, we review experimental tools and methods that have been developed to measure numerous cardiovascular parameters in these millimetre-sized animals...
  14. ncbi Measures of cardiovascular autonomic regulation derived from spontaneous methods and the Valsalva maneuver
    Eva Zollei
    Faculty of Medicine, Cardiology Center, Medical Intensive Care Unit, University of Szeged, Korányi fasor 7, Szeged 6720, Hungary
    Auton Neurosci 103:100-5. 2003
    ..We concluded that all of these methods are useful in calculating baroreflex gain, but owing to the differences in underlying physiological mechanisms, they are not necessarily in correlation with each other...
  15. ncbi Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats
    Jun Yang
    Department of Pharmacology, Second Military Medical University, 200433 Shanghai, China
    Exp Brain Res 160:467-72. 2005
    ..It is concluded that agmatine exerts a similar cardiovascular effect to clonidine, with less potency within the RVLM. Idazoxan might be a partial agonist for imidazoline I(1) receptors...
  16. ncbi Effects of long-term vegetarian diets on cardiovascular autonomic functions in healthy postmenopausal women
    Chin Hua Fu
    Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    Am J Cardiol 97:380-3. 2006
  17. ncbi Selective reductions of cardiac autonomic responses to light bicycle exercise with aging in healthy humans
    Daniela Lucini
    Centro Ricerca Terapia Neurovegetativa, Dipartimento Scienze Cliniche L Sacco, University of Milano, Via G B Grassi, 74 20157 Milan, Italy
    Auton Neurosci 110:55-63. 2004
    ..In conclusion, we have observed that aging progressively and selectively reduces the cardiac autonomic excitatory response to light exercise, while hemodynamic and vascular responsiveness are maintained...
  18. ncbi Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2
    Chun Shui Pan
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, PR China
    Peptides 26:1640-6. 2005
    ..These results suggest that IMD might be a regulatory factor for cardiovascular function and myocardial hypertrophy as a cardiovascular active peptide...
  19. ncbi Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic function
    G D Pinna
    Department of Biomedical Engineering, Fondazione S Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano, Pavia, Italy
    Am J Physiol Heart Circ Physiol 290:H424-33. 2006
    ..These findings support the notion that PB does not alter cardiovascular autonomic regulation compared with spontaneous breathing...
  20. ncbi Rhythmic activities of the sympatho-excitatory neurons in the medulla of rabbits: neurons controlling cutaneous vasomotion
    Youichirou Ootsuka
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    Auton Neurosci 101:48-59. 2002
    ..These results further showed that the Cu neurons controlled the cutaneous vasoconstrictor fibers and that the sympatho-excitatory neurons were located at the different sites in the ventral medulla according to their function...
  21. ncbi Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats
    Carlos Daniel Almeida Pitanga Landulpho
    Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP 04023 060, Brazil
    Am J Physiol Heart Circ Physiol 284:H987-93. 2003
    ..The tachycardia was not observed with a dose of 1,000 pmol/100 nl. The pressor response induced by microinjection of baclofen into the NTS of conscious rats may be produced by both increases in sympathetic tonus and vasopressin release...
  22. ncbi Abnormal postexercise cardiovascular recovery and its determinants in patients after right ventricular outflow tract reconstruction
    Hideo Ohuchi
    Department of Pediatrics, National Cardiovascular Center, Suita, Osaka, Japan
    Circulation 106:2819-26. 2002
    ..However, little is known about the postexercise dynamics...
  23. ncbi Baroreflex buffering is reduced with age in healthy men
    Pamela Parker Jones
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, UCB 354, Boulder, CO 80309, USA
    Circulation 107:1770-4. 2003
    ..Baroreflex buffering is an important mechanism in arterial blood pressure control. The effect of healthy (physiological) aging on tonic baroreflex buffering in humans is unknown...
  24. ncbi Hemodynamics during active and passive recovery from a single bout of supramaximal exercise
    Antonio Crisafulli
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Italy
    Eur J Appl Physiol 89:209-16. 2003
  25. ncbi Physiological adaptations to exercise in people with spinal cord injury
    J Vidal
    Hospital de Neurorehabilitació Guttmann, C Can Ruti s n, 08916 Badalona, Barcelona
    J Physiol Biochem 59:11-8. 2003
    ..Furthermore, this quantification may allow for the adaptation of exercise intensity to the patient thus improving the results obtained from the practice of exercise that has been proven so necessary in these patients...
  26. ncbi Human autonomic responses to blood donation
    Eva Zollei
    University of Szeged, Faculty of Medicine, Cardiology Center, Medical Intensive Care Unit, Korányi fasor 7, Szeged 6720, Hungary
    Auton Neurosci 110:114-20. 2004
    ..Vagal withdrawal was reflected in decreased root mean square of successive differences (RMSSD), decreased HF RRI power and decreased up sequence BRS...
  27. ncbi Assessment of cardiovascular autonomic function in myotonic dystrophy type 2 (DM2/PROMM)
    Peter Flachenecker
    Department of Neurology, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Neuromuscul Disord 13:289-93. 2003
  28. ncbi Autonomic cardiovascular changes during and after 14 days of head-down bed rest
    Kaname Hirayanagi
    Department of Hygiene and Space Medicine, Nihon University School of Medicine, 30 1 Ohyaguchi kamimachi, Itabash ku, Tokyo 173 8610, Japan
    Auton Neurosci 110:121-8. 2004
    ..Our results suggest that HF(RRI) and BRSsequence can be used effectively to reveal reductions in cardiac vagal nervous modulation on the sinus node and cardiac BRS within 24 h of both HDBR and post-HDBR...
  29. ncbi Central stresscopin modulates cardiovascular function through the adrenal medulla in conscious rats
    Chun Ping Chu
    Department of Physiology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki gun, Miyazaki 889 1692, Japan
    Regul Pept 119:53-9. 2004
    ..5 nmol) did not elicit significant changes in MABP and HR. Therefore, these data suggest that centrally administered SCP modulates cardiovascular function, likely through the sympatho-adrenal-medullary (SAM) system...
  30. ncbi [Effect of physical training on growth and total cardiovascular and respiratory capacity in pupils from schools with different physical training programs]
    Wojciech Szot
    Zakład Higieny i Ekologii, Collegium Medicum, Uniwersytet Jagiellonski, 31 034 Krakow
    Przegl Lek 60:76-80. 2003
    ..In addition we tried to evaluate the possible influence of diet on children growth...
  31. ncbi Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats
    Hidefumi Waki
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 91:201-13. 2006
    ..Moreover, we have confirmed its versatility by demonstrating its application to man...
  32. ncbi Late-developing rostral ventrolateral medullary surface responses to cardiovascular challenges during sleep
    Christopher A Richard
    Department of Neurobiology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095 1763, USA
    Brain Res 985:65-77. 2003
    ..The pattern of the late RVLMS responses was not dependent on arousal, and suggests that the RVLMS participates in both the early baroreflex response and the late-developing compensatory actions...
  33. ncbi Cardiopulmonary function in high altitude residents of Ladakh
    Steve Wood
    Department of Family and Community Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA
    High Alt Med Biol 4:445-54. 2003
    ..Improved lung mechanics may be an important adaptation to the lifelong sustained increase in resting ventilation as well as to indoor biomass smoke and outdoor dust exposure of these populations at high altitude...
  34. ncbi The effect of muscle contraction velocity on cardiorespiratory responses to repetitive isokinetic exercise in humans
    Naoyuki Hayashi
    School of Health and Sport Sciences and Graduate School of Engineering Sciences, Osaka University, Toyonaka, 560 0043 Japan
    Jpn J Physiol 53:327-33. 2003
    ..g., MAP: 12 +/- 2, 10 +/- 2, 11 +/- 2, and 18 +/- 2 mmHg in the A trial). The result suggests that muscle contraction velocity affects cardiorespiratory responses during repetitive isokinetic exercise...
  35. ncbi Role of MC4 receptors in the depressor and bradycardic effects of alpha-MSH in the nucleus tractus solitarii of the rat
    Jillian M Pavia
    Department of Neuroscience, Division of Pharmacology, Uppsala University, Sweden
    Neuroreport 14:703-7. 2003
  36. ncbi Effect of endothelin on vasomotor and respiratory neurons in the rostral ventrolateral medulla in rats
    Mamoru Kumada
    Department of Physiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cell Mol Neurobiol 23:691-707. 2003
    ..Majority of vasomotor and respiratory neurons should express ET-A receptors and some respiratory neurons are under tonic excitatory control by ET-1...
  37. pmc Bolus injection of human UII in conscious rats evokes a biphasic haemodynamic response
    Sheila M Gardiner
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham
    Br J Pharmacol 143:422-30. 2004
  38. ncbi Effects of graded load of artificial gravity on cardiovascular functions in humans
    Satoshi Iwase
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    Environ Med 46:29-32. 2002
    ..Artificial gravity by centrifuge at 1.2 or 1.4 G with 40 or 60 W of ergometric workload may be an excellent countermeasure against cardiovascular deconditioning after long exposure to microgravity...
  39. ncbi Quantitative Poincaré plot analysis of heart rate variability: effect of endurance training
    Laurent Mourot
    Laboratoire de Physiologie Médecine, Faculte de Medecine et de Pharmacie, Place St Jacques, 25030, Besancon Cedex, France
    Eur J Appl Physiol 91:79-87. 2004
    ..These results suggested that Poincaré plot parameters as well as the "width" of the scatter gram could be considered as surrogates of time- and frequency-domain analysis to assess training-induced changes in HRV...
  40. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  41. ncbi Performance diagnostics in handbiking during competition
    T Abel
    Institute of Motor Control and Movement Technique, German Sport University Cologne, Cologne, Germany
    Spinal Cord 44:211-6. 2006
    ..Case study in handbiking under competition conditions...
  42. ncbi Cardiovascular responses to somatosensory stimulation and their modulation by baroreflex mechanisms
    Tetsuya Kawabe
    Department of Neurological Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Clin Exp Hypertens 29:403-18. 2007
  43. ncbi Cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 291:H2142-51. 2006
    ..A cascade model of ventricular-arterial coupling with the arterial-cardiac baroreflex contributes to the genesis of cardiovascular variability at the respiratory frequency...
  44. ncbi Impact of retinopathy of prematurity screening examination on cardiorespiratory indices: a comparison of indirect ophthalmoscopy and retcam imaging
    Achyut N Mukherjee
    Department of Ophthalmology, University Hospital of Wales, Cardiff, United Kingdom
    Ophthalmology 113:1547-52. 2006
    ..To compare the impact of retinopathy of prematurity (ROP) screening examination between a digital fundus camera and conventional binocular indirect ophthalmoscopy (BIO) using cardiorespiratory indices as a measure of distress...
  45. ncbi Correlation between striatal dopamine D2/D3 receptor binding and cardiovascular activity in healthy subjects
    Tzung Lieh Yeh
    Department of Psychiatry, National Cheng Kung University Medical Center, and Department of Neurology, Cheng Ching Hospital, Tainan, Taiwan
    Am J Hypertens 19:964-9. 2006
    ..The relationship between the striatal dopaminergic system and cardiovascular activity is not well known. The aim of this study is to investigate the relationship between striatal D2/D3 receptor binding and cardiovascular activity...
  46. pmc Vasomotor sympathetic neural control is maintained during sustained upright posture in humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, TX 75231, USA
    J Physiol 577:679-87. 2006
    ..e. 45 min) orthostasis without obvious changes in vasomotor sympathetic neural control...
  47. ncbi The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome
    Dane B Cook
    University of Wisconsin, Madison, WI 53706, USA
    Arthritis Rheum 54:3351-62. 2006
    ..To investigate cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome (CFS), accounting for comorbid fibromyalgia (FM) and controlling for aerobic fitness...
  48. ncbi Respiratory effects on the reproducibility of cardiovascular autonomic parameters
    Eva Zollei
    Medical Intensive Care Unit, Department of Anaesthesiology and Intensive Care, University of Szeged, Szeged, Hungary
    Clin Physiol Funct Imaging 27:205-10. 2007
    ..In conclusion, respiration had a strong influence on the most widely used cardiovascular autonomic parameters. The controlling of breathing did not result in consistent improvement in their reproducibility...
  49. pmc Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Physiol 578:605-12. 2007
  50. ncbi Glutamatergic systems in the bed nucleus of the stria terminalis, effects on cardiovascular system
    Masoumeh Hatam
    Department of Physiology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
    Exp Brain Res 178:394-401. 2007
  51. ncbi Static magnetic field effect on the arterial baroreflex-mediated control of microcirculation: implications for cardiovascular effects due to environmental magnetic fields
    Juraj Gmitrov
    Department of Environmental Health, National Institute of Public Health, Tokyo, Japan
    Radiat Environ Biophys 46:281-90. 2007
    ..This could represent one possible mechanism how environmental magnetic fields act on the cardiovascular system, and a method how to complexly adjust macro- and microcirculation with potential clinical implementation...
  52. ncbi Cardiovascular and neurohormonal responses to lower body negative pressure (LBNP): effect of training and 3 day bed rest
    A Gasiorowska
    Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 57:85-100. 2006
    ..In conclusion, training has negligible effect on the HDBR-induced changes in central hemodynamics during LBNP but may increase vascular sensitivity to some vasoconstricting factors...
  53. ncbi Correlations between the Poincaré plot and conventional heart rate variability parameters assessed during paced breathing
    Przemysław Guzik
    Department of Cardiology Intensive Therapy, University of Medical Sciences in Poznan, Przybyszewskiego 49, 60 355 Poznan, Poland
    J Physiol Sci 57:63-71. 2007
    ..A physiological model of changing respiratory rates from 6 to 15 breaths/min provided a wide range of RR intervals for analysis...
  54. pmc Increases in central blood volume modulate carotid baroreflex resetting during dynamic exercise in humans
    Shigehiko Ogoh
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Physiol 581:405-18. 2007
    ..These findings suggest that changes in cardiopulmonary baroreceptor load influence carotid baroreflex resetting during dynamic exercise...
  55. ncbi Cold pressor test demonstrates residual sympathetic cardiovascular activation in familial dysautonomia
    M J Hilz
    Department of Neurology, New York University, New York, NY 10016, USA
    J Neurol Sci 196:81-9. 2002
    ..CPT assesses sympathetic cardiovascular responses independently from baroreflex function, which is compromised in FD...
  56. ncbi Combined influence of cardiorespiratory fitness and body mass index on cardiovascular disease risk factors among 8-18 year old youth: The Aerobics Center Longitudinal Study
    Joey C Eisenmann
    Department of Health and Human Performance, Iowa State University, Ames, IA 50010, USA
    Int J Pediatr Obes 2:66-72. 2007
    ..The purpose of this study was to examine differences in cardiovascular disease (CVD) risk factors across four cross-tabulated groups of cardiorespiratory fitness and body mass index in 8- to 18-year-old children and adolescents...
  57. ncbi Pulse transit time as an indirect marker for variations in cardiovascular related reactivity
    Jong Yong Abdiel Foo
    Biomedical Engineering Research Centre, Nanyang Technological University, Singapore
    Technol Health Care 14:97-108. 2006
    ..The attraction of PTT due to its non-invasive nature and revealing properties can only increase. Hence, the use of this simple technique in a clinical setting is still to realise its full potential...
  58. ncbi Menstrual cycle effects on the neurohumoral and autonomic nervous systems regulating the cardiovascular system
    Nir Hirshoren
    Jacob Recanati Autonomic Dysfunction Center, Department of Medicine C, Rambam Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    J Clin Endocrinol Metab 87:1569-75. 2002
    ..Fluctuations in the ovarian hormones along the menstrual cycle are associated with unchanged blood pressure and HR, despite the significant variations in the different homeostatic mechanisms regulating the cardiovascular system...
  59. ncbi [Physical performance and thermoregulatory study of subjects with sickle cell trait during a sub-maximal exercise]
    A Samb
    Laboratoire de Physiologie, Faculte de Medecine et Pharmacie, UCAD Dakar
    Dakar Med 50:46-51. 2005
    ..We can assure that subjects with SCT in our country may participate in sports competition, as well as normal subjects (HbAA)...
  60. ncbi Exercise training improves cardiovascular and autonomic profiles in HIV
    David K Spierer
    Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA
    Clin Auton Res 17:341-8. 2007
    ..Human immunodeficiency virus (HIV) is associated with cardiovascular (CV) and autonomic dysfunction, however the effects of fitness on vascular and autonomic mechanisms in HIV disease are unknown...
  61. ncbi Spectral analysis of pulse transit time variability and its coherence with other cardiovascular variabilities
    Heather T Ma
    Dept of Electron Eng, Chinese Univ of Hong Kong, Shatin Hong Kong, China
    Conf Proc IEEE Eng Med Biol Soc 1:6442-5. 2006
    ..The unstable coupling relationship of PTTV with BPV at LF should raise caution in the beat-to-beat BP estimation by PTT in the dynamic situation...
  62. pmc Graded associations between cardiorespiratory fitness, fatness, and blood pressure in children and adolescents
    L Klasson-Heggebø
    Norwegian School of Sports Sciences, Oslo, Norway
    Br J Sports Med 40:25-9; discussion 25-9. 2006
    ..To measure the graded relation between cardiorespiratory fitness and sum of skinfolds, waist circumference, and blood pressure in children and adolescents participating in the European youth heart study...
  63. ncbi Gill chemoreceptors and cardio-respiratory reflexes in the neotropical teleost pacu, Piaractus mesopotamicus
    C A C Leite
    Department of Physiological Sciences, Federal University of Sao Carlos, Via Washington Luiz, km 235, P O Box 676, Sao Carlos, SP, 13565 905, Brazil
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:1001-11. 2007
  64. ncbi Empirical mode decomposition to assess cardiovascular autonomic control in rats
    Edmundo Pereira de Souza Neto
    Laboratoire de Physique, CNRS UMR 5672, Ecole Normale Superieure de Lyon, 46, Allee d Italie, 69364 Lyon Cedex 07, France
    Fundam Clin Pharmacol 21:481-96. 2007
  65. ncbi Two short, daily activity bouts vs. one long bout: are health and fitness improvements similar over twelve and twenty-four weeks?
    Timothy J Quinn
    University of New Hampshire, Department of Kinesiology, Robert Kertzer Exercise Physiology Laboratory, Durham, 03824, USA
    J Strength Cond Res 20:130-5. 2006
    ..This study suggests that an INT exercise program, which is incremental in nature, provides comparable, and in some cases greater, health and fitness benefits than those expected following traditional CON exercise training...
  66. ncbi Autonomic nervous system control of the cardiovascular and respiratory systems in asthma
    M J Lewis
    Department of Sports Science, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Respir Med 100:1688-705. 2006
    ..The full extent of autonomic dysfunction, and its clinical implications, has yet to be fully determined and should be the subject of future investigation...
  67. ncbi Localized gene transfer and its application for the study of central cardiovascular control
    Yoshitaka Hirooka
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Auton Neurosci 126:120-9. 2006
    ..We applied this technique to hypertensive rats as well as in mice with heart failure to explore the pathophysiological significance of nitric oxide, reactive oxygen species, and Rho-kinase...
  68. ncbi Preserved autonomic function in amenorrheic athletes
    Megan M Wenner
    Department of Health, Nutrition, and Excercise Sciences, University of Delaware, Newark, DE 19716, USA
    J Appl Physiol (1985) 101:590-7. 2006
    ..In conclusion, AA do not display signs of impaired autonomic function and orthostatic responses compared with EA or EA-OC during the follicular phase of the menstrual cycle...
  69. ncbi Respiratory and cardiovascular actions of orexin-A in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Inohana 1 8 1 Chuo ku, Chiba City, Chiba 260 8670, Japan
    Neurosci Lett 385:131-6. 2005
    ..Moreover, orexin can affect the cardiorespiratory control system at multiple sites in different ways. Orexin-A seems not to be involved in respiratory reflex regulation in mice at least under anesthetized condition...
  70. ncbi Naturally occurring variation in cardiovascular traits among inbred mouse strains
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, MS 5038, Cleveland, Ohio 44106 5038, USA
    Genomics 79:679-85. 2002
  71. ncbi Nonprimate animal models of menopause: workshop report
    F L Bellino
    Biology of Aging Program, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    Menopause 7:14-24. 2000
    ..Thus, it may be useful to consider nonprimate animal species as potential models for pathophysiological changes associated with loss of reproductive function...
  72. ncbi Cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutions
    D R Spahn
    Institut für Anästhesiologie, Universitatsspital Zurich, Switzerland
    Anesth Analg 78:1000-21. 1994
    ..b>Cardiovascular physiology during hemodilution is characterized by a marked increase in cardiac output and organ blood flow to ..
  73. pmc Optimized surgical techniques and postoperative care improve survival rates and permit accurate telemetric recording in exercising mice
    Beat Schuler
    University of Zurich, Vetsuisse Faculty, Institute of Veterinary Physiology, and Zurich Center for Integrative Human Physiology, 8057 Zurich, Switzerland
    BMC Vet Res 5:28. 2009
    ..Telemetric transmitters are used to study cardiovascular physiology and diseases...
  74. ncbi [Contribution of transgenesis models in discovery of new pharmacological targets in heart failure: aldosterone receptor as an example]
    Celine Latouche
    Inserm U872, Centre de Recherche des Cordeliers, Paris, France
    Therapie 64:81-6. 2009
    ..Furthermore these models allow testing of new hypothesis and therapeutic approaches, although cardiovascular physiology and physiopathological patterns are far different in animals than in humans (haemodynamic conditions, ..
  75. ncbi Mechanism of cocaine-induced hyperthermia in humans
    Craig G Crandall
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    Ann Intern Med 136:785-91. 2002
    ..However, because cocaine-induced hyperthermia occurs primarily in hot weather, it is hypothesized that cocaine also impairs thermoregulatory adjustments that mediate heat dissipation...
  76. ncbi Optic nerve oxygen tension in pigs and the effect of carbonic anhydrase inhibitors
    E Stefansson
    Department of Ophthalmology, University of Iceland, Reykjavik
    Invest Ophthalmol Vis Sci 40:2756-61. 1999
    ..To evaluate how the oxygen tension of the optic nerve (ONP(O)2) is affected by the administration of the carbonic anhydrase inhibitors dorzolamide and acetazolamide and by alterations in oxygen and carbon dioxide in the breathing mixture...
  77. ncbi Characterization of the effects of vasoactive substances on the bulbus arteriosus of the eel, Anguilla rostrata
    David H Evans
    Mt Desert Island Biological Laboratory, Salsbury Cove, Maine 04672, USA
    J Exp Zool A Comp Exp Biol 297:45-51. 2003
    ..The role of agonist-induced changes in BA tension in fish cardiovascular physiology remains to be determined, as do the specific receptor types involved.
  78. ncbi The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Pharmacol Ther 114:295-306. 2007
    ..The vascular endothelium plays a key role in cardiovascular physiology and pathophysiology, largely via NO-dependent processes...
  79. ncbi Cardiovascular response to exercise
    M H Laughlin
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Am J Physiol 277:S244-59. 1999
    This article is intended for instructors who teach cardiovascular physiology. In our physiology course exercise physiology is used as a tool to review and integrate cardiovascular and respiratory physiology...
  80. ncbi Endothelin: role in hypertension
    E L Schiffrin
    MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Biol Res 31:199-208. 1998
    ..These peptides may play important roles in cardiovascular physiology and pathophysiology...
  81. ncbi Influence of alpha-chloralose on reflex control of the cardiovascular system in lambs
    G G Konduri
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock
    J Dev Physiol 13:87-91. 1990
    Alpha-chloralose is an anesthetic agent sometimes used for experiments in fetal and neonatal cardiovascular physiology. However, its effect on baseline cardiovascular variables and reflex control of the circulatory system has not been ..
  82. ncbi Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure
    Amie K Lund
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Toxicol Appl Pharmacol 193:177-87. 2003
    ..Genetic deletion of the AhR leads to cardiac hypertrophy, suggesting a role for the AhR in cardiovascular physiology and disease; however, the pathways involved in the development of cardiac hypertrophy have not been ..
  83. ncbi Frequency response of implantable blood pressure telemetry systems
    Daniel McCormick
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Clin Exp Pharmacol Physiol 37:862-9. 2010
    ..of blood pressure via telemetry in a variety of animal species has become an indispensable part of cardiovascular physiology, drug development and safety pharmacology. 2...
  84. pmc Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure
    Adrian Shifren
    Department of Internal Medicine, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    J Appl Physiol (1985) 105:1610-9. 2008
    ..better understand how elastin insufficiency influences the pulmonary circulation, we evaluated pulmonary cardiovascular physiology in a unique set of transgenic and knockout mice with graded vascular elastin dosage (range 45-120% of ..
  85. ncbi Cardiovascular physiology during supine cycle ergometry and dobutamine stress
    James F Cnota
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Med Sci Sports Exerc 35:1503-10. 2003
    ..This study compared cardiac hemodynamics during supine cycle ergometry and dobutamine stress...
  86. ncbi Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
    Circ Res 98:105-10. 2006
    The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial...
  87. ncbi Effect of pentobarbital anesthesia on the pressor response to agonists in vivo in normal and endotoxemic rats
    G J Hauser
    Division of Pediatric Critical Care Medicine, Georgetown University Children s Medical Center, Washington, DC 20007, USA
    Res Commun Mol Pathol Pharmacol 90:289-300. 1995
    Studies of cardiovascular physiology are frequently performed under barbiturate anesthesia even though the effect of barbiturates on the pressor response to catecholamines is controversial, and their effect on the response to other ..
  88. ncbi Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy
    Paula A Witt-Enderby
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    J Pineal Res 41:297-305. 2006
    ..Interestingly, many of these genes support a role for melatonin in modulating metabolic and cardiovascular physiology as well as bone metabolism and immune function and detoxification of chemical agents and cancer ..
  89. pmc Saline volume expansion and cardiovascular physiology: novel observations, old explanations, and new questions
    James L Robotham
    Department of Anesthesiology, University of Rochester, Rochester, New York, USA
    Crit Care 8:315-8. 2004
  90. ncbi Effects of sex and estrogen on chicken ductus arteriosus reactivity
    Thijs W H Flinsenberg
    Department of Pediatrics, Maastricht University Medical Center, GROW School for Oncology and Developmental Biology, P Debyelaan 25, Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 298:R1217-24. 2010
    Sex hormones have an important influence on cardiovascular physiology and pathophysiology and sex differences in vascular reactivity have been widely demonstrated...
  91. ncbi Teaching principles of cardiovascular function in a medical student laboratory
    Sanjaya Gupta
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Adv Physiol Educ 29:118-27. 2005
    ..The laboratory demonstration has proven effective in reinforcing the fundamental principles of cardiovascular physiology and autonomic pharmacology...
  92. ncbi Response by the corpuscles of Stannius to hypotensive stimuli in three divergent ray-finned fishes (Amia calva, Anguilla rostrata, and Catastomus commersoni): cardiovascular and morphological changes
    D G Butler
    Department of Zoology, University of Toronto, Toronto, Ont, Canada M5S 3G5
    Gen Comp Endocrinol 132:198-208. 2003
    In accordance with their vital role in cardiovascular physiology () corpuscles of Stannius (CS) from two teleosts and an holostean species showed marked and consistent degranulation and exocytotic responses to hypotensive stimuli...
  93. ncbi Anatomy, physiology, and pathophysiology of erectile dysfunction
    Christian Gratzke
    Department of Urology, Ludwig Maximilians Universitat, Munchen, Germany
    J Sex Med 7:445-75. 2010
    ..A critical evaluation of the current state of knowledge is essential to provide perspective for future research and development of new therapies...
  94. pmc Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system
    Vera Jankowski
    Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik IV, Berlin, Germany
    Br J Pharmacol 157:1142-53. 2009
    ..Interest in the role of the purinergic system in cardiovascular physiology and pathophysiology is on the rise...
  95. ncbi Clinical impact of evaluation of cardiovascular control by novel methods of heart rate dynamics
    Heikki V Huikuri
    Department of Internal Medicine, Institute of Clinical Medicine, Centre of Excellence in Research, University of Oulu, Oulu 90014, Finland
    Philos Trans A Math Phys Eng Sci 367:1223-38. 2009
    ..complexity measures of heart rate behaviour, heart rate turbulence, deceleration capacity in relation to cardiovascular physiology or various cardiovascular events are still far away from clinical medicine, they are a fruitful area for ..
  96. ncbi Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 291:R481-8. 2006
    Exposure of the early gestation ovine fetus to exogenous glucocorticoids induces alterations in postnatal cardiovascular physiology, including hypertension...
  97. ncbi A look at the brighter facets of β-N-oxalyl-l-α,β-diaminopropionic acid, homoarginine and the grass pea
    S L N Rao
    Department of Biochemistry, Osmania University, Hyderabad, India
    Food Chem Toxicol 49:620-2. 2011
    ..NO is well recognized for its role in cardiovascular physiology and general well-being and thus a daily dietary intake of homoarginine through small quantities of L...
  98. ncbi Proteomic analysis of epicardial and subcutaneous adipose tissue reveals differences in proteins involved in oxidative stress
    Antonio Salgado-Somoza
    Laboratory 6, Area Cardiovascular, Instituto de Investigaciones Sanitarias, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain
    Am J Physiol Heart Circ Physiol 299:H202-9. 2010
    ..Locally produced adipokines may reflect or affect to cardiovascular physiology and pathology...
  99. ncbi Protein kinase G activity prevents pathological-level nitric oxide-induced apoptosis and promotes DNA synthesis/cell proliferation in vascular smooth muscle cells
    Janica C Wong
    Cancer Molecular Biology Section, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    Cardiovasc Pathol 19:e221-31. 2010
    Protein kinase G (PKG), a recognized downstream mediator of nitric oxide, is a key regulator of cardiovascular physiology and pathology...
  100. ncbi Postoperative cardiorespiratory instability following ligation of the preterm ductus arteriosus is related to early need for intervention
    L S Teixeira
    Department of Paediatrics, University of Toronto, Toronto, ON, Canada
    J Perinatol 28:803-10. 2008
    ..To investigate the effect of postnatal age at patent ductus arteriosus (PDA) ligation on postoperative need for cardiotropic support...
  101. ncbi Comparative cardiovascular development: improving the conceptual framework
    Warren Burggren
    Department of Biological Sciences, University of North Texas, Denton 76205, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:661-74. 2002
    ..Their cardiovascular physiology (and doubtlessly other aspects of physiology) differs from that of adults both qualitatively and ..

Research Grants72

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..Experts in the fields of reproduction and cardiovascular physiology, with both nonhuman primate and clinical research experience, have been recruited to oversee the ..
  2. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..Bring together leaders in the field of autonomic cardiovascular physiology and pathophysiology for an intense discussion of the current research and therapy related to ..
  3. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..novel imaging techniques for studying the myocardial microcirculation, and swine models that mimic human cardiovascular physiology and pathophysiology, now provide a unique opportunity to serially assess the effects of MetS on ..
  4. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    ..the strengths of two investigators, one with extensive experience in mitochondrial bioenergetics and cardiovascular physiology, and the other in nematode ion channel physiology, to test the hypothesis that KATP and KCa channel ..
  5. Role of Central Neural NFkB and ER Stress in Obesity-induced Hypertension
    COLIN NEAL YOUNG; Fiscal Year: 2013 the setting of obesity-induced hypertension and build logically upon the PI's background in cardiovascular physiology and sympathetic neural recordings in humans...
  6. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
    ..The GSTs are expressed in cardiovascular tissues, but the role of GST in cardiovascular physiology and pathology has not been studied...
  7. Diet and pathophysiology of heart failure with preserved ejection fraction
    Scott L Hummel; Fiscal Year: 2013
    ..We hypothesize that dietary patterns recommended for hypertension will 1) improve cardiovascular physiology, and 2) decrease systemic and cellular oxidative stress and inflammation in patients with hypertensive ..
  8. Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2013
    ..peptide-1 (GLP-1) on the heart have been recently recognized, but little is known regarding the cardiovascular physiology of this incretin hormone...
  9. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..project is to determine the importance of the occipital artery-nodose ganglion complex in integrative cardiovascular physiology in control rats and in 2-kidney-1 clip (2K-1C) hypertensive rats, a clinically-relevant model of humoral ..
  10. Reduced contractile reserve: a therapeutic target in heart failure with normal EF
    Nancy K Sweitzer; Fiscal Year: 2012
    ..This project explores the underlying cardiovascular physiology of patients with HFpEF with the goal of identifying new therapeutic targets that would allow improved ..
  11. Role of Acid-Sensing Ion Channels in Pulmonary Vascular Smooth Muscle Store-Opera
    Nikki L Jernigan; Fiscal Year: 2012
    ..Under the proposed training plan, Dr. Jernigan will build upon her background in cardiovascular physiology and develop new expertise in electrophysiology and calcium imaging. Other facets of Dr...
  12. Oxidant Stress in the Brain and Hypertension
    Robin L Davisson; Fiscal Year: 2013
    ..Aim 3 will utilize SFO-targeted genetic manipulations of ER capacity combined with integrative cardiovascular physiology to test the hypothesis that ER stress in the SFO is a causal factor in slow-pressor AngII HTN and ..
  13. Micro-RNA Profiling and Cardiovascular Effects of Traffic Particle Exposure
    Lifang Hou; Fiscal Year: 2012
    ..Gene expression alterations may then cause certain changes in circulating biomarkers and cardiovascular physiology to favor CVD development...
  14. The roles of primary cilia in cardiovascular system
    SURYA NAULI; Fiscal Year: 2012
    ..proposed study will also advance scientific understanding of cilia biology in fluid sensing related to cardiovascular physiology and pathophysiology...
  15. Pre-Clinical Development of a Fetal Micropacemaker
    Ramen Chmait; Fiscal Year: 2013
    ..Dr. Ja Pruetz has unique expertise in fetal cardiac imaging and fetal cardiovascular physiology, which will be vital for the implantation and follow-up of the device...
    Arthur Karlin; Fiscal Year: 2011
    ..calcium-and-voltage-activated potassium (BK) channel are vital participants in normal and pathological cardiovascular physiology. Each is a tetramer of pore-forming subunits in a complex with auxiliary subunits that allosterically ..
  17. Endothelial Ca2+ signals and vasodilatory function after traumatic brain injury
    Kalev Freeman; Fiscal Year: 2013
    ..He now combines his strength in cardiovascular physiology with his clinical experience with traumatic brain injury (TBI), to create a novel and highly ..
    Jonathan A Epstein; Fiscal Year: 2012
    ..We will then extend these findings to elucidate adult cardiovascular physiology. We will examine the role of neurofibromin in angiogenesis and endothelial function, using tissue ..
  19. Role of Redox-Mediated Activation of NFkappaB and AP-1 in Neurogenic Hypertension
    Robin L Davisson; Fiscal Year: 2010
    ..brain site-specific viral delivery of oxidant scavenging and dominant-suppressor genes, and integrative cardiovascular physiology in mice, we will perform the following studies: Aim 1) Spatiotemporally map and quantify NFkappaB and AP-..
  20. The Stress of Chronic Disease: Mineralocorticoid Mediation of Mood
    Alan Kim Johnson; Fiscal Year: 2013
    ..methods from behavioral neuroscience, preclinical psychopharmacology, experimental cardiology, and cardiovascular physiology will be used to answer a series of key experimental questions...
  21. Role of Gbeta 2 in the Nucleus of Angiotensin Receptor Activated Cells
    Anushree Bhatnagar; Fiscal Year: 2010
    The rennin-angiotensin system hormone, angiotensin II (Ang II) is a master regulator of normal cardiovascular physiology. Normally, Ang II regulates acute changes in blood pressure and water-electrolyte balance...
  22. The Role of Galectin-3 in Cardiac Remodeling and Heart Failure
    JENNIFER EN SIAN HO; Fiscal Year: 2013
    ..cardiac and vascular imaging;(3) to become facile with patient-oriented intervention studies in cardiovascular physiology;and (4) to establish an independent clinical research career. In order to achieve these goals, Dr...
  23. Mind-body therapies for patients with end-stage renal disease
    GURJEET SINGH BIRDEE; Fiscal Year: 2013
    ..Through focused didactics in clinical research methodology and laboratory training to measure relevant cardiovascular physiology, the candidate will acquire the necessary skills to conduct proposed and future research...
  24. Cardiovascular System: Function, Regulation &Pharmacology
    Jeanne M Nerbonne; Fiscal Year: 2013
    ..and mentoring to Predoctoral and Postdoctoral Trainees in Modern Cardiovascular Biology, including cardiovascular physiology, biochemistry, cell biology, genetics, imaging, modeling, and disease mechanisms...
  25. Acute and Chronic Afferent Engagement: Sympathetic and End Organ Responses
    Lawrence I Sinoway; Fiscal Year: 2013
    ..2 and 3)};2) conceptual synergy exists between the projects that will lead to important advances in cardiovascular physiology and pathophysiology;3) this PPG has broadly defined goals that can be accomplished within the first 5 ..
  26. Impact of Aging on Skeletal Muscle Blood Flow Kinetics During Exercise
    DARREN PATRICK CASEY; Fiscal Year: 2013
    ..Importantly, this training will facilitate the achievement of the applicant's long-term goal to develop an internationally-renowned independent research program in cardiovascular physiology.
  27. Impact of Aging on Skeletal Muscle Blood Flow Kinetics During Exercise
    DARREN PATRICK CASEY; Fiscal Year: 2012
    ..Importantly, this training will facilitate the achievement of the applicant's long-term goal to develop an internationally-renowned independent research program in cardiovascular physiology.
  28. Hsp90, NOS3 and Cardioprotection
    Yang Shi; Fiscal Year: 2009
    ..from these studies may actually unify two hypotheses that many consider competing hypotheses in cardiovascular physiology and may also lead to the development of new strategies for treating ischemic heart disease...
  29. CNS PPARg, Stress, &Cardiovascular Disease
    Karen Ryan; Fiscal Year: 2013
    ..Karen Ryan's continued training in the field of Metabolic Diseases, focusing on cardiovascular physiology and stress neurobiology, and will facilitate her transition to independence...
  30. Preclinical Evaluation of the Adjustable Systemic-Pulmonary Artery Shunt
    ..Dr. Mohiuddin has unique training in mechanical device design (BS, MS in Mechanical Eng) and cardiovascular physiology (PhD in Biomedical Sciences) which is necessary for the project...
    Craig J Hartley; Fiscal Year: 2012
    ..goals have been to develop ultrasonic instrumentation, transducers, and techniques for evaluation of cardiovascular physiology and function in man and in animal models of human diseases and conditions, and recently we have been ..
  32. Metabolism, Skeletal Muscle, Cardiac Disease, Exercise
    John P Konhilas; Fiscal Year: 2010
    ..Konhilas, Ph.D., is a research associate endeavoring to broaden his extensive training in cardiovascular physiology to encompass additional biological systems and timely molecular techniques. Dr...
  33. Cardiovascular Research Training Program (CRTP)
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..These include completion of a required graduate course in Cardiovascular Physiology, an exciting Immersion Experience in Cardiovascular Healthcare, participation in the weekly seminar ..
  34. Renal blood flow, vascular stiffness, and the DASH diet
    Paul R Conlin; Fiscal Year: 2012
    ..destined for careers in patient-oriented research, particularly those interested in renal and cardiovascular physiology, interventional nutrition or diabetes care management...
  35. Sleep Restriction and Augmented Vascular Risk in Prehypertension
    Virend K Somers; Fiscal Year: 2012 successful ongoing studies and have several decades of experience in conducting human studies of cardiovascular physiology. Comprehensive serial physiologic data will be complemented by detailed translational molecular studies ..
  36. Training Grant in Cardiac and Vascular Cell Biology
    Steven A Fisher; Fiscal Year: 2013
    ..provides a high-quality interdisciplinary training experience for pre- and postdoctoral trainees in cardiovascular physiology and pathophysiology...
  37. Antipsychotics and Vascular Function in Bipolar Disorders
    Jess G Fiedorowicz; Fiscal Year: 2013
    ..Jess G. Fiedorowicz. His goal is to develop expertise in human cardiovascular physiology for the assessment of vascular function in patients with bipolar disorder...
  38. The Virtual Physiological Rat Project
    Daniel A Beard; Fiscal Year: 2013
    ..RELEVANCE: Despite a depth of knowledge of basic cardiovascular physiology, we lack even a rudimentary understanding of how multiple genes and environmental factors interact to ..
  39. Molecular Analysis of Cardiovascular Biology and Pathology
    Monty Krieger; Fiscal Year: 2010
    ..a successful 16+ year history of this program, will accelerate research accomplishments in the individual laboratories and significantly contribute to our understanding of cardiovascular physiology and pathophysiology.
  40. Induction of Cardiovascular Cells from hESCs by Embryonic Cues
    John W Lough; Fiscal Year: 2013
    ..Success achieving these tasks will be prmoted by synergy provided from Administrative (A), ES Cell (B), Cardiovascular Physiology (C) and Histology &Imaging (D) Cores
  41. TRPC3 Channels in Molecular and Cellular Events of Atherogenesis
    Guillermo Vazquez; Fiscal Year: 2013
    ..applicant): Transient Receptor Potential Canonical (TRPC) Ca2+permeable channels play critical roles in cardiovascular physiology. TRPCs are now also recognized as critical components in signaling processes associated to several ..
    Robert P Mecham; Fiscal Year: 2012
    ..elastin crosslinking provide a regulatory signal that influences smooth muscle cell differentiation and cardiovascular physiology. We also propose that elastin-derived ROS influence the angiotensin signaling pathway and that this ..
  43. Training In Cardiovascular Physiology &Pharmacology
    Kirk U Knowlton; Fiscal Year: 2013
    ..This proposal will facilitate the continued pattern of success that has been established over the years. (End of Abstract) ..
  44. Support for the recruit of a tenure track faculty member, Lie Gao, M.D., Ph.D.
    Irving H Zucker; Fiscal Year: 2010
    ..Upon Dr. Irving Zucker becoming Chairman in 1989 cardiovascular physiology became even more prominent following strategic recruitments and the acquisition of a Program Project ..
    Fred W Turek; Fiscal Year: 2012 sleep research in the context of cutting edge research in broader biomedical research areas such as cardiovascular physiology, respiratory biology, metabolism and functional genomics...
  46. The role of post-translational acetylation in SERCA2a-related cardiac dysfunction
    Changwon Kho; Fiscal Year: 2013
    ..objectives of this application are a group of investigators and collaborators with expertise in cardiovascular physiology, advanced proteomics, viral vector construction and development of crucial professional skills...
  47. Depression treatment and risk for cardiovascular disease
    MATTHEW CHARLES WHITED; Fiscal Year: 2013
    ..Whited with additional knowledge in depression, its treatment, cardiovascular physiology, autonomic imbalance, along with the experience and expertise necessary to study primary CVD risk using ..
  48. A systems approach to metabolic dysregulation in the heart
    Mohit Jain; Fiscal Year: 2013
    ..Through the career and scientific plans outlined, the applicant aims to leverage his prior training in cardiovascular physiology and disease with newly acquired skills in systems analysis, genomics, metabolomics and macro-molecule ..
  49. Multidisciplinary Training in Cardiovascular Research
    ROBERT JAMES BACHE; Fiscal Year: 2013
    ..areas: (1) cardiac development and regeneration from stem cell populations;(2) molecular and integrative cardiovascular physiology;(3) cardiovascular applications of nuclear magnetic resonance, and (4) clinical and epidemiologic ..
  50. TGF-beta1 activity in the aortic valve
    WILLIAM D MERRYMAN; Fiscal Year: 2013
    ..Louis J. Dell'ltalia, an expert in cardiovascular physiology, valvular disease, and left ventricle remodeling...
    David M Pollock; Fiscal Year: 2013
    ..the first year core curriculum and passing the first qualifying exam;advanced course electives such as Cardiovascular Physiology &Pharmacology and Frontiers in Vascular Biology;courses in Scientific Communications and Research ..
  52. Pathways of fetal programming of coronary dysfunction
    Robert D Roghair; Fiscal Year: 2010
    ..Fred Lamb acting as co-sponsor. They are well established investigators in ovine cardiovascular physiology, and their mutual interest in the study of coronary artery dysfunction 'fosters an intellectually ..
    Igor R Efimov; Fiscal Year: 2012
    ..small rodents a powerful platform for investigation of the genetic foundation of normal and pathological cardiovascular physiology. Through these studies, primarily in mice, many cardiovascular diseases have been linked to a particular ..
    Gordon H Williams; Fiscal Year: 2013
    ..of lectures and seminars that provide all trainees with broad exposure to endocrine, renal and cardiovascular physiology and pathophysiology, vascular biology, laboratory and patient-oriented research human subjects and ..
    Karen Matthews; Fiscal Year: 2013
    ..necessary for conducting research and for drawing valid inferences from empirical data are developed; Cardiovascular physiology and psychophysiology, through which an understanding of cardiovascular functioning and of methodologies ..
  56. The Role of Hedgehog Interacting Protein in Sonic Hedgehog Mediated Agiogenesis
    Rajesh Gupta; Fiscal Year: 2012
    ..However, its role in adult cardiovascular physiology and in Shh mediated angiogenesis is poorly understood...
  57. Digitalis-Induced Signaling by Cardiac Na+/K+-ATPase
    Amir Askari; Fiscal Year: 2013
    ..expertise in membrane biochemistry, protein chemistry, molecular genetics, cell biology, and integrative cardiovascular physiology/ pharmacology will combine their efforts to conduct the following studies: Project I attempts to ..
  58. Short Course in Integrative and Organ Systems Pharmacology
    Myron L Toews; Fiscal Year: 2012
    ..of IACUCs, the humane treatment of animals and applicable regulations, background material on cardiovascular physiology, pharmacology and neuropharmacology...
  59. Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular Reactivity
    Deidre Wipke Tevis; Fiscal Year: 2009
    ..for our multidisciplinary team, will assist us to bridge basic and applied science in one area of cardiovascular physiology. An understanding of the seasonal rhythms of these important cardiovascular parameters will lay the ..
  60. Physiology of Mind-Body Therapies: Meditative Breathing and Autonomic Adaptations
    Suzanne Bertisch; Fiscal Year: 2013
    ..Her immediate goal is to acquire knowledge and skills in autonomic cardiovascular physiology and mind-body clinical trial methodology. Dr...
  61. Vevo 2100 Imaging System
    Mark L Kahn; Fiscal Year: 2013
    ..This instrument will be housed in the Cardiovascular Physiology Core facility at the University of Pennsylvania Translational Research Center (TRC)...
    Faye Calhoun; Fiscal Year: 2010 development program aimed at increasing the number of minority scientists conducting research on cardiovascular physiology and disease...
  63. Annual Conference: Computers in Cardiology
    Robert Arzbaecher; Fiscal Year: 2003
    ..the application of engineering and computer technology to problems in clinical cardiology and basic cardiovascular physiology. The conference meets on even-numbered years in the United States, and on odd-numbered years in Europe...
    Judy Kersten; Fiscal Year: 2001
    ..these objectives by providing opportunities for advance education in molecular and cellular biology and cardiovascular physiology in a rich and varied academic research environment...
  65. Cardiovascular Causes of Falls/Syncope in the Elderly
    Mathew Maurer; Fiscal Year: 2005
    ..professional career have demonstrated a strong commitment to understanding how age related changes in cardiovascular physiology result in falls/syncope in the most rapidly growing segment of the population...
    BRENT FRENCH; Fiscal Year: 2006
    ..approach will be used that encompasses the fields of biomedical engineering, radiology, cardiovascular physiology, pharmacology, immunopathology, cell biology and molecular genetics...
    NICHOLAS OLIVIER; Fiscal Year: 1991
    ..My aim in Phase I is to complete the Ph.D. Program in cardiovascular Physiology that I began in 7/85...
  68. Cellular Mechanisms in the Pathogenesis of FHC
    JIL TARDIFF; Fiscal Year: 2006
    ..function and lead to distinct myocellular responses which may result in maladaptive changes in cardiovascular physiology. In order to address this question we have recently developed two independent transgenic mouse models ..
    JOAN CARROLL; Fiscal Year: 2004
    ..the department, there is a wide variety of expertise in human, animal, in vivo, and in vitro studies in cardiovascular physiology and endocrinology...
  70. Desensitization of Vascular Receptor Tyrosine Kinases
    Neil Freedman; Fiscal Year: 2009
    ..will examine agonist-induced seryl phosphorylation and tyrosyl autophosphorylation in RPTKs important to cardiovascular physiology, using smooth muscle cells or fibroblasts derived from GRK2-, GRK5-, or GRK6-knockout mice, or from ..
  71. Development of a humanized anti-CD47 antibody for treatment of tissue ischemia.
    William Frazier; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Nitric oxide (NO) is a critical regulator of cardiovascular physiology, coordinating the activities of the endothelium, the vessel wall and circulating cells to optimize the flow of blood and oxygen ..
  72. Sustained Coronary Stenosis and Hibernating Myocardium
    RAYMOND KUDEJ; Fiscal Year: 2005 residency and PhD program in biomedical engineering and received his postdoctoral training in cardiovascular physiology at Harvard Medical School...