platelet aggregation


Summary: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.

Top Publications

  1. ncbi Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice
    M Aviram
    Lipid Research Laboratory and the Division of Morphological Sciences, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Am J Clin Nutr 71:1062-76. 2000
  2. pmc Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    K M Hodivala-Dilke
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 103:229-38. 1999
  3. ncbi Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial
    Matthew J Price
    Scripps Clinic, La Jolla, California, USA
    JAMA 305:1097-105. 2011
  4. ncbi Cytochrome p-450 polymorphisms and response to clopidogrel
    Jessica L Mega
    Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 360:354-62. 2009
  5. pmc A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation
    Jindrich Chmelar
    Institute of Parasitology, Biology Centre of the Academy of Sciences of Czech Republic, Ceske Budejovice, Czech Republic
    Blood 117:736-44. 2011
  6. pmc Salivary antigen-5/CAP family members are Cu2+-dependent antioxidant enzymes that scavenge O₂₋. and inhibit collagen-induced platelet aggregation and neutrophil oxidative burst
    Teresa C F Assumpção
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 288:14341-61. 2013
  7. ncbi A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Melbourne, Victoria, Australia
    Nat Med 15:665-73. 2009
  8. pmc An important role for Akt3 in platelet activation and thrombosis
    Kelly A O'Brien
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
    Blood 118:4215-23. 2011
  9. pmc Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis
    K Przyklenk
    Center for Platelet Function Studies, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Thromb Haemost 8:331-40. 2010
  10. ncbi Platelets at work in primary hemostasis
    Katleen Broos
    Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kortrijk, Belgium
    Blood Rev 25:155-67. 2011

Detail Information

Publications341 found, 100 shown here

  1. ncbi Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice
    M Aviram
    Lipid Research Laboratory and the Division of Morphological Sciences, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Am J Clin Nutr 71:1062-76. 2000
    ..Pomegranates are a source of polyphenols and other antioxidants...
  2. pmc Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    K M Hodivala-Dilke
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 103:229-38. 1999
    beta3 integrins have been implicated in a wide variety of functions, including platelet aggregation and thrombosis (alphaIIbbeta3) and implantation, placentation, angiogenesis, bone remodeling, and tumor progression (alphavbeta3)...
  3. ncbi Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial
    Matthew J Price
    Scripps Clinic, La Jolla, California, USA
    JAMA 305:1097-105. 2011
    ..High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this issue is not well defined...
  4. ncbi Cytochrome p-450 polymorphisms and response to clopidogrel
    Jessica L Mega
    Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 360:354-62. 2009
    ..Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function...
  5. pmc A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation
    Jindrich Chmelar
    Institute of Parasitology, Biology Centre of the Academy of Sciences of Czech Republic, Ceske Budejovice, Czech Republic
    Blood 117:736-44. 2011
    b>Platelet aggregation and acute inflammation are key processes in vertebrate defense to a skin injury. Recent studies uncovered the mediation of 2 serine proteases, cathepsin G and chymase, in both mechanisms...
  6. pmc Salivary antigen-5/CAP family members are Cu2+-dependent antioxidant enzymes that scavenge O₂₋. and inhibit collagen-induced platelet aggregation and neutrophil oxidative burst
    Teresa C F Assumpção
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 288:14341-61. 2013
    ..Dipetalogaster maxima (DMAV) and Triatoma infestans (TIAV) were expressed and discovered to attenuate platelet aggregation, ATP secretion, and thromboxane A2 generation by low doses of collagen (<1 μg/ml) but no other agonists...
  7. ncbi A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Melbourne, Victoria, Australia
    Nat Med 15:665-73. 2009
    b>Platelet aggregation at sites of vascular injury is essential for hemostasis and arterial thrombosis...
  8. pmc An important role for Akt3 in platelet activation and thrombosis
    Kelly A O'Brien
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
    Blood 118:4215-23. 2011
    ..Akt3(-/-) mouse platelets selectively exhibit impaired platelet aggregation and secretion in response to low concentrations of thrombin receptor agonists and thromboxane A₂ (TXA₂),..
  9. pmc Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis
    K Przyklenk
    Center for Platelet Function Studies, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Thromb Haemost 8:331-40. 2010
    ..and activation of serotonin 5HT2A receptors on platelet surfaces is a potent augmentative stimulus for platelet aggregation. However, earlier-generation serotonin receptor antagonists were not successfully exploited as antiplatelet ..
  10. ncbi Platelets at work in primary hemostasis
    Katleen Broos
    Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kortrijk, Belgium
    Blood Rev 25:155-67. 2011
    ..With this review, we intend to give an integrated survey of the platelet response to vascular injury in normal hemostasis...
  11. pmc Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
    M L Kahn
    Cardiovascular Research Institute and Daiichi Research Center, University of California San Francisco, San Francisco, California 94143 0130, USA
    J Clin Invest 103:879-87. 1999
    ..These observations suggest that PAR1 and PAR4 account for most, if not all, thrombin signaling in platelets and that antagonists that block these receptors might be useful antithrombotic agents...
  12. ncbi Identification of the platelet ADP receptor targeted by antithrombotic drugs
    G Hollopeter
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 409:202-7. 2001
    ..ADP released from damaged vessels and red blood cells induces platelet aggregation through activation of the integrin GPIIb-IIIa and subsequent binding of fibrinogen...
  13. pmc Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
    Andrew J Webb
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Hypertension 51:784-90. 2008
    ..dysfunction induced by an acute ischemic insult in the human forearm and significantly attenuated ex vivo platelet aggregation in response to collagen and ADP...
  14. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...
  15. pmc PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation
    Michael Holinstat
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 281:26665-74. 2006
    ..Evidence is lacking on the mechanism by which PAR1 and PAR4 may differentially signal platelet aggregation. Here we show that at the relatively high concentration of agonist most likely found at the site of a local ..
  16. ncbi Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects
    Pierre Fontana
    Service d Hématologie Biologique A, Hôpital Européen Georges Pompidou and Inserm Unité 428, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
    Circulation 108:989-95. 2003
    The adenosine diphosphate (ADP) receptor P2Y12 plays a pivotal role in platelet aggregation, as demonstrated by the benefit conferred by its blockade in patients with cardiovascular disease...
  17. ncbi Cytotoxicity and inhibition of platelet aggregation caused by an l-amino acid oxidase from Bothrops leucurus venom
    Gustavo B Naumann
    Research and Development Center, Ezequiel Dias Foundation, 30510 0103, Belo Horizonte, Brazil
    Biochim Biophys Acta 1810:683-94. 2011
    ..Multifunctional l-amino acid oxidases (LAAOs) occur widely in snake venoms...
  18. ncbi Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation
    Li Liu
    Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China
    J Ethnopharmacol 139:381-7. 2012
  19. pmc Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2alpha, and 15(S)-HETE
    Teresa C F Assumpção
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892 8132, USA
    J Biol Chem 285:39001-12. 2010
    ..superfamily and has strong sequence similarity to pallidipin, a salivary inhibitor of collagen-induced platelet aggregation. DPTL expressed in Escherichia coli was found to inhibit platelet aggregation by collagen, U-46619, or ..
  20. ncbi Signaling events underlying thrombus formation
    S P Jackson
    Australian Center for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    J Thromb Haemost 1:1602-12. 2003
    ..The role of soluble agonists in promoting thrombus growth will be highlighted and a model to explain the synergistic requirement for adhesive and soluble stimuli for efficient platelet aggregation will be discussed.
  21. pmc The anti-aggregating effect of BAY 41-2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide
    Séverine Roger
    Département Angiologie, Institut de Recherches Servier, 11 rue des Moulineaux, Suresnes, France
    Br J Pharmacol 161:1044-58. 2010
    The purpose of the present study was to determine whether a stimulator of soluble guanylyl cyclase, BAY 41-2272, inhibits platelet aggregation and to clarify its interaction with nitric oxide (NO).
  22. pmc Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s The Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 42:608-13. 2010
    ..We tested association of 2.5 million SNPs with platelet aggregation responses to three agonists (ADP, epinephrine and collagen) in two cohorts of European ancestry (N<or=2,..
  23. pmc PKCalpha regulates platelet granule secretion and thrombus formation in mice
    Olga Konopatskaya
    Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Clin Invest 119:399-407. 2009
    ..Furthermore, defective platelet aggregation in response to either collagen-related peptide or thrombin could be overcome by an increase in agonist ..
  24. ncbi Genetic determinants of response to clopidogrel and cardiovascular events
    Tabassome Simon
    Assistance Publique Hopitaux de Paris, Hopital Saint Antoine, and Universite Pierre et Marie Curie, Paris 06, France
    N Engl J Med 360:363-75. 2009
    ..The effect of these determinants on clinical outcomes after an acute myocardial infarction is unknown...
  25. ncbi Inhibition of human platelet aggregation by L-amino acid oxidase purified from Naja naja kaouthia venom
    Y Sakurai
    Department of Blood Transfusion Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan
    Toxicon 39:1827-33. 2001
    ..The function of snake venom LAOs in hemostasis, especially their effect on platelet aggregation, has been controversial. We determined the N-terminal amino acid sequence of the N. n...
  26. pmc Nanoparticle-induced platelet aggregation and vascular thrombosis
    Anna Radomski
    Centre for Vascular Biology, Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Centre at Houston, 6770 Bertner Ave, Houston, TX 77025, USA
    Br J Pharmacol 146:882-93. 2005
    ..We studied the effects of engineered and combustion-derived carbon nanoparticles on human platelet aggregation in vitro and rat vascular thrombosis in vivo...
  27. ncbi Inhibition of 5-hydroxytryptamine receptor prevents occlusive thrombus formation on neointima of the rabbit femoral artery
    K Nishihira
    Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    J Thromb Haemost 4:247-55. 2006
    ..However, the roles of 5-HT2A receptor in occlusive thrombus formation on disrupted plaque remain obscure...
  28. ncbi Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes
    Robert F Storey
    Cardiovascular Research Unit, University of Sheffield, Sheffield, United Kingdom
    J Am Coll Cardiol 50:1852-6. 2007
    ..clopidogRel in non-ST-segment Elevation myocardial infarction)-2, we compared the antiplatelet effects of AZD6140 and clopidogrel and assessed the effects of AZD6140 in clopidogrel-pretreated patients...
  29. pmc Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis
    Jessica L Mega
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 376:1312-9. 2010
    ..We also assessed the effect of genotype on the pharmacodynamic and pharmacokinetic properties of these drugs in healthy individuals...
  30. pmc A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, D 80636 München, Germany
    J Exp Med 197:41-9. 2003
  31. ncbi Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    Dirk Sibbing
    Deutsches Herzzentrum Munchen, Lazarettstrasse 36, 80636 München, Germany
    Circulation 121:512-8. 2010
    ..The aim of this study was to assess the impact of CYP2C19*17 on ADP-induced platelet aggregation, the risk of bleeding, and stent thrombosis in clopidogrel-treated patients undergoing percutaneous ..
  32. ncbi Nucleotide receptor signaling in platelets
    B N Kahner
    The Cell Signaling Group, Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    J Thromb Haemost 4:2317-26. 2006
    ..Furthermore, costimulation of both P2Y1 and P2Y12 receptors is required for ADP-induced platelet aggregation. ATP stimulation of P2X1 is involved in platelet shape change and helps to amplify platelet responses ..
  33. pmc Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling
    Jeff S Isenberg
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:613-23. 2008
    ..Although some fragments and peptides derived from thrombospondin-1 stimulate or inhibit platelet aggregation, its physiologic function in platelets has remained elusive...
  34. pmc S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation
    Joseph E Aslan
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA
    Blood 118:3129-36. 2011
    ..mTOR inhibitors dramatically reduced collagen-induced platelet aggregation and promoted the destabilization of platelet aggregates formed under shear flow conditions...
  35. pmc Elucidation of flow-mediated tumour cell-induced platelet aggregation using an ultrasound standing wave trap
    D Bazou
    Centre for Research on Adaptive Nanostructures and Nanodevices, Trinity College Dublin, Dublin, Ireland
    Br J Pharmacol 162:1577-89. 2011
    Tumour cells activate and aggregate platelets [tumour cell-induced platelet aggregation (TCIPA)] and this process plays an important role in the successful metastasis of cancer cells...
  36. ncbi Platelet function testing in atherothrombotic disease
    Erik Lerkevang Grove
    Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, 8200 Aarhus, Denmark
    Curr Pharm Des 18:5379-91. 2012
  37. pmc Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice
    Arunima Ghosh
    Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
    J Clin Invest 118:1934-43. 2008
    ..These results provide what we believe to be a novel role for CD36 in thrombosis...
  38. pmc Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred
    Nicolas Prevost
    Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:9219-24. 2002
    ..Blockade of Eph/ephrin interactions prevented the formation of these complexes and caused platelet aggregation at low ADP concentrations to become more readily reversible...
  39. ncbi Isolation and characterization of an apoptotic and platelet aggregation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom
    Mari Samel
    National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia
    Biochim Biophys Acta 1764:707-14. 2006
    ..Five amino acids, L-Ser, L-Pro, Gly, L-Thr and L-Cys, were not oxidized. The enzyme inhibited ADP-induced platelet aggregation dose-dependently with an IC50 of 0.07 microM. The effect was neutralized by catalase. V...
  40. ncbi Acute microvascular platelet aggregation after subarachnoid hemorrhage
    Fatima A Sehba
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosurg 102:1094-100. 2005
    ..In the present study the authors examined the hypothesis that platelets aggregate within the cerebral microvasculature acutely after SAH...
  41. ncbi Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors
    Yukinari Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 278:51599-605. 2003
    ..We have previously characterized the platelet aggregation-inducing sialoglycoprotein (Aggrus/gp44) overexpressed on the surface of tumor cells...
  42. ncbi Adiponectin inhibits hyperlipidemia-induced platelet aggregation via attenuating oxidative/nitrative stress
    W Q Wang
    Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Physiol Res 60:347-54. 2011
    ..Adiponectin acts as an endogenous antithrombotic factor. However, the mechanisms underlying the inhibition of platelet aggregation by adiponectin still remain elusive...
  43. ncbi Distinct role and location of the endothelial isoform of nitric oxide synthase in regulating platelet aggregation in males and females in vivo
    Christopher Moore
    National Heart and Lung Institute, Imperial College, London, UK
    Eur J Pharmacol 651:152-8. 2011
    ..We employed a mouse model of platelet thromboembolism to assess platelet aggregation in vivo along with supporting in vitro studies to investigate these issues...
  44. ncbi Platelet aggregation is dependent on platelet count in patients with coronary artery disease
    Morten Würtz
    Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    Thromb Res 129:56-61. 2012
    ..This study investigated the importance of platelet count, haematocrit, red blood cells (RBC), and white blood cells in whole blood platelet aggregometry...
  45. ncbi Genetic and environmental contributions to platelet aggregation: the Framingham heart study
    C J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 103:3051-6. 2001
    b>Platelet aggregation plays an important role in arterial thrombosis in coronary heart disease, stroke, and peripheral arterial disease...
  46. ncbi Rac1 is essential for phospholipase C-gamma2 activation in platelets
    Irina Pleines
    Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
    Pflugers Arch 457:1173-85. 2009
    ..Together, these results demonstrate that Rac1 is essential for ITAM-dependent PLCgamma2 activation in platelets and that this is critical for thrombus formation in vivo...
  47. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  48. ncbi Increased platelet reactivity in HIV-1-infected patients receiving abacavir-containing antiretroviral therapy
    Claudette S Satchell
    HIV Molecular Research Group, School of Medicine and Medical Sciences, University College Dublin, Ireland
    J Infect Dis 204:1202-10. 2011
    ..Given the role of platelet aggregation in thrombus formation in MI and the reversible nature of the abacavir association, we hypothesized that ..
  49. pmc Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
    Donna Woulfe
    Department of Medicine, University of Pennsylvania, Philadelphia, USA
    J Clin Invest 113:441-50. 2004
    ..Deletion of the gene encoding Akt2 impaired platelet aggregation, fibrinogen binding, and granule secretion, especially in response to low concentrations of agonists that ..
  50. pmc Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin
    Endrit Ziu
    Department of Biochemistry and Molecular Biology, College of Medicine, The University of Arkansas for Medical Sciences, Arkansas, USA
    J Mol Cell Cardiol 52:1112-21. 2012
    ..a mechanistic link between elevated plasma [5-HT], abnormal intracellular 5-HT signaling and accentuated platelet aggregation. Although a down-regulation of the serotonin transporter (SERT) on the platelet surface may counteract the ..
  51. ncbi Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice
    J E Fabre
    Department of Medicine, University of North Carolina, CB 7248, Chapel Hill, Thurston Bowles Bld, Durham, North Carolina, USA
    Nat Med 5:1199-202. 1999
    ..Adenosine 5'-diphosphate (ADP) induces platelet aggregation, but the mechanism for this has not been established, and the relative contribution of ADP in hemostasis ..
  52. pmc Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome
    Joanna Sikora
    Department of Pharmaceutical Chemistry and Drug Analyses, Medical University of Lodz, Muszynskiego 1, 90 151, Lodz, Poland
    Eur J Nutr 51:549-56. 2012
    ..The aim of our study was to investigate the effects of A. melanocarpa extract (AM) supplementation on platelet aggregation, clot formation, and lysis in patients with metabolic syndrome (MS).
  53. pmc Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice
    C Leon
    Institut National de la Santé et de la Recherche Médicale INSERM U 311, Etablissement de Transfusion Sanguine, 10, rue Spielmann, B P 36, 67065 Strasbourg, France
    J Clin Invest 104:1731-7. 1999
    ..of ADP and display impaired aggregation to other agonists, while high concentrations of ADP induce platelet aggregation without shape change...
  54. ncbi Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biochem 150:127-32. 2011
    ..The absence of CLEC-2 does not significantly increase bleeding tendency, implying that CLEC-2 may be a good target protein for anti-platelet drugs in addition to anti-metastatic drugs...
  55. pmc Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation
    Joanna Lecka
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Québec Pavillon CHUL and Départament de Microbiologie Infectiologie, Faculte de Medecine, Universite Laval, 2705 Boulevard Laurier, Quebec, QC, Canada
    Br J Pharmacol 161:1150-60. 2010
    ..Here we evaluate the effect of these pro-drugs on vascular ectonucleotidase activity and on the natural function of these enzymes in regulating platelet aggregation.
  56. ncbi Krüppel-like factor 10 upregulates the expression of cyclooxygenase 1 and further modulates angiogenesis in endothelial cell and platelet aggregation in gene-deficient mice
    Diane H A Yang
    Department of Life Science, National Cheng Kung University, Taiwan
    Int J Biochem Cell Biol 45:419-28. 2013
    ..angiogenesis, the its deficient mice exhibited decreased light transmission which represents the extend of platelet aggregation slowing down...
  57. ncbi Prevention of hematogenous metastasis by neutralizing mice and its chimeric anti-Aggrus/podoplanin antibodies
    Youya Nakazawa
    The Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan
    Cancer Sci 102:2051-7. 2011
    The platelet aggregation-inducing factor, Aggrus (also known as podoplanin), is reported to contribute to cancer metastasis by mediating cancer cell-platelet interaction...
  58. pmc Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway
    Guoying Zhang
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Immunol 182:7997-8004. 2009
    ..activation was abolished by an anti-TLR4-blocking Ab or TLR4 knockout, suggesting that the effect of LPS on platelet aggregation requires the TLR4 pathway...
  59. ncbi Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase
    Jiiang Huei Jeng
    Laboratory of Dental Pharmacology and Toxicology, Graduate Institute of Clinical Dental Science, National Taiwan University, Taipei, Taiwan
    Free Radic Biol Med 32:860-71. 2002
    ..AN extract (1 and 2 mg/ml) stimulated rabbit platelet aggregation, with induction of thromboxane B2 (TXB2) production...
  60. ncbi Endogenous peroxynitrite modulates PGHS-1-dependent thromboxane A2 formation and aggregation in human platelets
    Stefan Schildknecht
    Vascular Biology Unit, Boston University School of Medicine, Boston, MA, 02118, USA
    Free Radic Biol Med 45:512-20. 2008
    ..and O*2 with the PGHS pathway and suggests a mechanism by which antioxidants can regulate PGHS-1-dependent platelet aggregation. This may provide a molecular explanation for the clinically observed hyperreactivity of platelets in high-..
  61. ncbi New insights into the haemostatic function of platelets
    Andrew H Wei
    The Australian Centre for Blood Diseases, Monash University, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia
    Br J Haematol 147:415-30. 2009
  62. ncbi Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans
    Martin Ungerer
    Martinsried, Germany
    Circulation 123:1891-9. 2011
    ..A dose-escalating clinical phase I study was performed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of Revacept in humans...
  63. ncbi Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease
    Guido Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cardiovasc Drug Rev 25:30-45. 2007 cardiovascular regulation by promoting vasodilation and inhibiting vascular smooth muscle cell growth, platelet aggregation, and leukocyte adhesion...
  64. ncbi Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects
    George B Kudolo
    Department of Clinical Laboratory Sciences, MSC 6246, School of Allied Health Sciences, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229 3900, USA
    Thromb Res 108:151-60. 2002
    ..This study was designed to compare the effect of ingesting G. biloba extract on platelet aggregation in platelet-rich plasma (PRP) and prostanoid urinary excretion in healthy volunteers and subjects with Type ..
  65. ncbi The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation
    Sonia Philipose
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, A 8010 Graz, Austria
    Arterioscler Thromb Vasc Biol 30:2416-23. 2010
    Low concentrations of prostaglandin (PG) E(2) enhance platelet aggregation, whereas high concentrations inhibit it...
  66. ncbi Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits
    Seock Yeon Hwang
    Department of Clinical Laboratory Science, Juseong College, Cheongwongun, Chungbuk 363 794, Korea
    Phytother Res 22:778-83. 2008
    ..ginseng (KRG, ginseng Radix rubra), rich in glycosylated saponins (ginsenosides), has been known to inhibit platelet aggregation in the normocholesterolemic condition...
  67. ncbi The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase
    Jung Jin Lee
    Department of Pharmacology, Chungnam National University College of Pharmacy, Daejeon, 305 764, Korea
    Arch Pharm Res 33:387-94. 2010
    ..Paclitaxel inhibited washed rabbit platelet aggregation induced by collagen in a concentration dependent manner, with an IC(50) of 59.7 +/- 3.5...
  68. ncbi Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway
    Daniel Yacoub
    Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 30:2424-33. 2010
    ..We aimed to determine the impact and the signaling mechanisms of sCD40L on platelets...
  69. ncbi Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida 32209, USA
    J Am Coll Cardiol 48:298-304. 2006
    ..This study sought to assess the influence of type 2 diabetes mellitus (T2DM) and the impact of hypoglycemic treatment (insulin vs. noninsulin) on platelet function profiles in patients treated with dual oral antiplatelet therapy...
  70. pmc Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets
    Soochong Kim
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 284:33763-72. 2009
    ..Moreover, GPVI-mediated platelet aggregation, secretion, and intracellular Ca(2+) mobilization were significantly inhibited by TGX-221, and less ..
  71. ncbi Mechanisms of flavonoid protection against myocardial ischemia-reperfusion injury
    Masoumeh Akhlaghi
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada S7N 5C9
    J Mol Cell Cardiol 46:309-17. 2009
    ..Flavonoids also possess anti-inflammatory and anti-platelet aggregation effects through inhibiting relevant enzymes and signaling pathways, resulting ultimately in lower oxidant ..
  72. ncbi Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody
    Wolfgang Bergmeier
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, Wuppertal, Germany
    Cytometry 48:80-6. 2002
    ..On human platelets, the high affinity conformation of alphaIIbbeta3 is detected by the monoclonal antibody (mAb), PAC-1. However, a reagent with binding specificity to high affinity mouse alphaIIbbeta3 has not been described so far...
  73. ncbi Abciximab, eptifibatide, and tirofiban exhibit dose-dependent potencies to dissolve platelet aggregates
    Martin Moser
    Division of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Cardiovasc Pharmacol 41:586-92. 2003
    Platelet GPIIb/IIIa antagonists are not only used to prevent platelet aggregation, but also in combination with thrombolytic agents for the treatment of coronary thrombi...
  74. pmc Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice
    Juhua Chen
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, NB50, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Blood 104:1703-10. 2004
    ..Using ex vivo techniques, we showed that Akt-1-deficient mice exhibited impaired platelet aggregation and spreading in response to various agonists...
  75. ncbi Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation
    Mhairi J Maxwell
    Australian Centre for Blood Diseases, Monash University, 89 Commercial Rd, Prahran, Australia, 3181
    Blood 109:566-76. 2007
    ..of platelets have been extensively investigated in vitro; however, the mechanisms by which shear promotes platelet aggregation in vivo remain incompletely understood...
  76. pmc Signaling during platelet adhesion and activation
    Zhenyu Li
    Department of Medicine, University of Kentucky, Lexington, USA
    Arterioscler Thromb Vasc Biol 30:2341-9. 2010
    ..Recent studies have provided novel insight into the molecular mechanisms of these processes...
  77. ncbi Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin
    C Marcinkiewicz
    Sol Sherry Thrombosis Research Center, Department of Pharmacology, and Department of Physiology, Temple University, School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 39:9859-67. 2000
    ..EMS16 inhibits collagen-induced platelet aggregation, but has no effect on aggregation induced by other agonists such as ADP, thromboxane analogue (U46619), ..
  78. pmc CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets
    Stephen M Cifuni
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 112:1696-703. 2008
    Second messenger-mediated inside-out activation of integrin alphaIIbbeta3 is a key step in platelet aggregation. We recently showed strongly impaired but not absent alphaIIbbeta3-mediated aggregation of CalDAG-GEFI-deficient platelets ..
  79. ncbi Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation
    I Jantan
    Department of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Phytomedicine 15:306-9. 2008
    ..xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood...
  80. pmc GSK3beta is a negative regulator of platelet function and thrombosis
    Dongjun Li
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 111:3522-30. 2008
    ..Taken together, these results suggest that GSK3beta acts as a negative regulator of platelet function in vitro and in vivo...
  81. ncbi Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets
    Mark K Larson
    Department of Pharmacology, Center for Thrombosis and Hemostasis and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Blood 101:1409-15. 2003
    ..P2Y(12)-dependent and -independent components are also observed in GPVI-mediated platelet aggregation, further supporting a role for Rap1 in aggregation...
  82. ncbi A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Blood 101:4423-9. 2003
    ..Furthermore, PKA inhibitors reverse cGMP-induced inhibition of thrombin-induced platelet aggregation, whereas PKG inhibitors further enhance the inhibitory effect of cGMP analogs...
  83. ncbi Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease
    E L Grove
    Departments ofCardiology Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus, Denmark
    J Thromb Haemost 9:185-91. 2011
    ..Previous studies have demonstrated considerable variation in the antiplatelet effect of aspirin...
  84. ncbi CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
    Jill R Crittenden
    Department of Brain and Cognitive Sciences, and McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 618, Cambridge, Massachusetts 02139, USA
    Nat Med 10:982-6. 2004
    ..These results suggest that analogous signaling defects are likely to occur in the central nervous system when CalDAG-GEFI is absent or compromised in function...
  85. ncbi Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets
    Peter A Smethurst
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 282:1296-304. 2007
    ..b>Platelet aggregation and protein tyrosine phosphorylation were induced only by cross-linked peptides and only those that ..
  86. ncbi L-amino acid oxidase from Trimeresurus jerdonii snake venom: purification, characterization, platelet aggregation-inducing and antibacterial effects
    Qiu Min Lu
    Department of Animal Toxinology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    J Nat Toxins 11:345-52. 2002
    ..The enzyme-induced aggregation was inhibited by catalase, suggesting formation of H2O2 was essential for TJ-LAO to induce platelet aggregation. These results showed H2O2 formation is important for the biological effects of LAO.
  87. pmc A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
    M Moroi
    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan
    J Clin Invest 84:1440-5. 1989
    ..The patient's platelets did not bind to types I and III collagen fibrils. Our results suggest that GPVI functions as a collagen receptor...
  88. ncbi Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors
    Jianguo Jin
    Department of Physiology, Temple University Medical School, Philadelphia, PA 19140, USA
    Blood 99:193-8. 2002
    ..SC49992, a fibrinogen receptor antagonist, blocked ADP-induced platelet aggregation and thromboxane A(2) production in a concentration-dependent manner...
  89. ncbi Triatoma infestans apyrases belong to the 5'-nucleotidase family
    Eric Faudry
    Chagas Disease Multidisciplinary Research Laboratory, Department of Pathology, Faculty of Medicine, University of Brasilia, Brazil 70 910 900
    J Biol Chem 279:19607-13. 2004
    ..activity found in the saliva of hematophagous insects is correlated with the prevention of ADP-induced platelet aggregation of the host during blood sucking...
  90. pmc Plasma fibronectin promotes thrombus growth and stability in injured arterioles
    Heyu Ni
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:2415-9. 2003
  91. ncbi Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure?
    Rocio Gonzalez-Conejero
    University of Murcia, Centro Regional de Hemodonacion, Ronda de Garay S N, 30003, Murcia, Spain
    Stroke 36:276-80. 2005
    ..The widespread use of aspirin requires clarification of the aspirin resistance phenomenon. Most studies on this field are focused on patients which may affect the action of aspirin...
  92. ncbi The growing complexity of platelet aggregation
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Blood 109:5087-95. 2007
    b>Platelet aggregation, the process by which platelets adhere to each other at sites of vascular injury, has long been recognized as critical for hemostatic plug formation and thrombosis...
  93. ncbi Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis
    Youya Nakazawa
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo
    Blood 112:1730-9. 2008
    ..CD9 expression reduced lung retention and platelet aggregation activity of the transfectants...
  94. ncbi Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis
    Pierre Savi
    Cardiovascular Thrombosis Research Department, Sanofi Aventis Recherche, 195 route d Espagne, 31036 Toulouse Cedex, France
    Semin Thromb Hemost 31:174-83. 2005
    ..b>Platelet aggregation is affected not only when triggered by ADP but also by aggregation inducers when used at concentrations ..
  95. ncbi Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release
    J E Freedman
    Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Circulation 103:2792-8. 2001
    ..Acute cardiac events are also associated with decreased platelet-derived nitric oxide (NO) release. In this study, the effects of PGJ and PGJ-derived flavonoids on platelet function and platelet NO production were determined...
  96. ncbi Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    J T Brandt
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Thromb Haemost 5:2429-36. 2007
    ..The pharmacodynamic response to clopidogrel is more variable than the response to prasugrel, but the reasons for variation in response to clopidogrel are not well characterized...
  97. pmc A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    Susan Sather
    Department of Pediatrics, University of Colorado at Denver, and Health Sciences Center, Aurora, CO 80045, USA
    Blood 109:1026-33. 2007
    ..Mer regulates macrophage activation, promotes apoptotic cell engulfment, and supports platelet aggregation and clot stability in vivo...
  98. pmc PGE2 decreases reactivity of human platelets by activating EP2 and EP4
    James P Smith
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Thromb Res 126:e23-9. 2010
    ..Studies in mice and humans suggest that prostaglandin E2 (PGE2) regulates platelet activation. In mice, activation of the PGE2 receptor subtype 3 (EP3) promotes thrombosis, but the significance of EP3 in humans is less well understood...
  99. ncbi Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial
    Christopher D Gardner
    Stanford Prevention Research Center and the Department of Medicine, Stanford University Medical School, Stanford, California, USA
    Blood Coagul Fibrinolysis 18:787-93. 2007
    ..Ginkgo biloba (EGb 761, 300 mg/day) was compared with placebo for effects on measures of platelet aggregation among adults consuming 325 mg/day aspirin in a randomized, double-blind, placebo-controlled, parallel ..
  100. ncbi Comparison of early platelet activation in patients undergoing on-pump versus off-pump coronary artery bypass surgery
    Andrea Ballotta
    Department of Cardiac Surgery and Critical Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
    J Thorac Cardiovasc Surg 134:132-8. 2007
    ..Off-pump coronary artery bypass surgery is thought to avoid this deleterious effect of pump use on platelets. However, the influence of off-pump coronary artery bypass surgery on platelets has not been thoroughly studied...
  101. ncbi Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP
    Whi Min Lee
    Laboratory of Veterinary Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 702 701, Korea
    J Pharm Pharmacol 60:1531-6. 2008
    ..Dihydroginsenoside Rg3 inhibited thrombin-induced platelet aggregation in a concentration-dependent manner with an IC50 (concentration producing 50% inhibition) of 18.8 +/- 0...

Research Grants67

  1. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..platform system), TF function in carotid artery homogenates and mononuclear peritoneal cells and platelet aggregation, in annexin A2, in myeloid differentiation factor (MyD)88 - an intracellular protein downstream from TLR-4, ..
  2. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..RELEVANCE: Control of cell adhesion is important in targeting immune cells to sites of inflammation, in platelet aggregation, and in cancer cell metastasis among other functions...
  3. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    Endothelial dysfunction and platelet aggregation cause pulmonary artery vasoconstriction, mitogenesis, thrombosis, and vascular obliteration in pulmonary arterial hypertension (PAH) The recognition of abnormal eicosanoid metabolism and ..
  4. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..The vascular endothelium plays an important role in regulating blood flow, in inhibiting platelet aggregation and in the immune and inflammatory response...
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    Endothelial cells (ECs) regulate vascular tone, leukocyte function and platelet aggregation through the release of several soluble mediators including PGI2, nitric oxide and endothelium-dependent hyperpolarizing factor (EDHF)...
  6. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2013
    ..of this project we developed a series of new bis-adenosine tetraphosphate (Ap4A) analogs, which inhibit platelet aggregation by a unique new mechanism, targeting both platelet ADP receptors, P2Y1 and P2Y12...
  7. Nitrite Mediated Cardioprotection
    DAVID JOSEPH LEFER; Fiscal Year: 2012
    ..These include vasodilation and the inhibition of oxidative stress, platelet aggregation, leukocyte chemotaxis and apoptosis...
  8. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    ..The endothelial isoform of NOS (eNOS) controls vascular constriction and dilation and has effects on platelet aggregation, with pathologies including hypertension and other vascular diseases...
    FRANCES ANN WALKER; Fiscal Year: 2012
    ..The NPs act as vasodilators, anti-platelet aggregation and anti-histaminic agents when injected into the victim...
  10. Translational studies of the Platelet Specific Receptor Trem Like Transcript (TLT
    A Valance Washington; Fiscal Year: 2013
    ..The soluble form of TLT-1 (sTLT-1) significantly enhances platelet aggregation and actin polymerization in platelets and endothelial cells;and Treml1 null mice show distinct phenotypic ..
  11. Phase 2 Study of High Dose DHA for the Treatment of X-Linked Retinitis Pigmentosa
    Dennis R Hoffman; Fiscal Year: 2013
    ..Blood DHA analysis (every 6 months) and biosafety measures (annually) assess RBC fatty acids, platelet aggregation, plasma vitamins A and E, plasma antioxidant capacity, plasma malonyldialdehyde, plasma oxidized low-..
  12. Pharmacogenomics of CVD risk Reduction
    ALAN SHULDINER; Fiscal Year: 2009
    ..We propose to treat these same subjects with clopidogrel and to obtain measures of platelet aggregation and function...
  13. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..of maternal platelets causes placental failure through mechanisms that do not require thrombosis or platelet aggregation. We examine the contributions of platelet receptors [unreadable]II[unreadable]b3, GPIB-V-IX and GPVI, and ..
  14. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle A Williams; Fiscal Year: 2012
    ..are associated with preeclampsia risk;and (2) to evaluate mechanistic hypotheses concerning the role of platelet aggregation and activation in preeclampsia...
  15. 12-HETrE regulation of platelets
    MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013 order to regulate physiological endpoints (granule secretion, integrin activation, cell adhesion, and platelet aggregation) in the platelet...
  16. Role of Innate Immune System in Pathogen Induced Chronic Inflammation
    Caroline A Genco; Fiscal Year: 2013
    ..While many strains of bacteria induce platelet aggregation, the mechanisms by which bacteria stimulate platelets has had minimal investigation...
  17. Factor XI in Thrombosis
    David Gailani; Fiscal Year: 2013
    ..of contact activation to thrombosis in humans, we noted that fXII contributes to fibrin formation and platelet aggregation in human blood in an ex vivo flow model...
  18. Regulatory Circuits Controlling Development of Dormant Microbial Cysts
    CARL EUGENE BAUER; Fiscal Year: 2013
    ..cGMP is a well known messenger in eukaryotes where it is involved in vision, muscle contraction, platelet aggregation, and development. However, its involvement in bacteria has until now been quite controversial...
  19. Novel Signaling Pathways in Ischemic Stroke
    JAMES KUANG JAN LIAO; Fiscal Year: 2013
    ..Because changes in the actin cytoskeleton underlie platelet aggregation, vascular contractility, and inflammatory cell recruitment, it is likely that the Rho/ROCK pathway will ..
  20. Pin1 prolyl isomerase regulates endothelial nitric oxide synthase
    Richard C Venema; Fiscal Year: 2013
    ..NO released from the endothelium also modulates other processes as well including platelet aggregation, platelet and leukocyte adhesion to the endothelium, vascular smooth muscle cell proliferation, endothelial ..
  21. Genetic regulation of racial differences in platelet reactivity
    MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013
    ..Our preliminary data demonstrates, for the first time, 1) racial differences in PAR4-mediated platelet aggregation, and 2) platelet mRNAs and microRNAs that are differentially expressed (DE) between blacks and whites and ..
  22. Cell-Cell Interactions in Thrombosis -Request for Extension of Merit Award
    AARON JACOB MARCUS; Fiscal Year: 2013
    ..This abolishes aggregation and recruitment. Recombinant, soluble human CD39 (solCD39) blocks human platelet aggregation in v#ro, and inhibits porcine and routine platelet aggregation ex vivo...
  23. Soluble guanylyl cyclase modulation by endogenous elements and exogenous factors
    Emil Martin; Fiscal Year: 2012
    ..guanylyl cyclase is a key enzyme in regulation of vascular smooth muscle relaxation, blood pressure, platelet aggregation, angiogenesis etc...
  24. A Network-based Approach to Associate HDL Subspeciation with Function
    Long Lu; Fiscal Year: 2013
    ..measured as activation of endothelial nitric oxide synthase (eNOS);and (d) inhibition of agonist induced platelet aggregation. 2. Prediction of HDL interactome network using an integrative approach...
  25. Redox Regulation of the rho-GTPases in the vasculature
    Sharon L Campbell; Fiscal Year: 2012
    ..altered cell contractility and cell migration such as vascular hyperpermeability, tumor cell invasion, platelet aggregation, atherosclerosis and restenosis and cardiac hypertrophy...
  26. Role of Hyperglycemia in Intracerebral Hemorrhage
    Edward P Feener; Fiscal Year: 2013
    ..These studies have revealed a novel function of plasma kallikrein in the inhibition of platelet aggregation, which is an early event in establishing hemostasis following cerebral vascular injury...
  27. Role of Beta 3 Integrin in Skeletal Metastasis
    ..and aIIb[unreadable]3) play critical roles in tumor invasion and metastasis by mediating bone resorption, platelet aggregation, and neo-angiogenesis...
  28. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2010 applicant): Phase I resulted in our discovery of low nanomolar level inhibitors of ADP-induced human platelet aggregation, with a unique mechanism of action, that warrant further development as first-in-class antithrombotic drugs...
  29. Akt-regulated pathways in platelet function
    Donna S Woulfe; Fiscal Year: 2011
    ..GSKSbeta acts to suppress platelet function, and that the removal or inhibition of GSKSbeta should enhance platelet aggregation or thrombosis. Our preliminary data suggest that this is the case...
  30. Glutamate Mediates Platelet Activation through an Ionotropic Glutamate Receptor
    Craig N Morrell; Fiscal Year: 2012
    ..Using flow cytometry, platelet aggregation, and whole cell patch clamp techniques we will further dissect platelet glutamate signaling...
  31. A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial Stents
    Guillermo A Ameer; Fiscal Year: 2010
    ..Given that NO inhibits platelet aggregation and vascular smooth muscle cell proliferation and stimulates endothelial cell growth, and given the ..
  32. Metabolomics Network for Drug Response Phenotype
    RIMA F KADDURAH DAOUK; Fiscal Year: 2010
    ..Controlling blood pressure and preventing platelet aggregation are major contributors toward reducing CVD events...
    Mariah S Hahn; Fiscal Year: 2013
    ..Given that platelet aggregation and smooth muscle cell proliferation may be mediated by controlling endothelial cell (EC) growth and ..
  34. Role of Beta 3 Integrin in Skeletal Metastasis
    Katherine Weilbaecher; Fiscal Year: 2009
    ..and [unreadable]IIb[unreadable]3) play critical roles in tumor metastasis by mediating bone resorption, platelet aggregation, and neo-angiogenesis...
  35. Expression of PKG in Vascular Smooth Muscle Cells
    Thomas M Lincoln; Fiscal Year: 2013
    ..The resultant lesions cause disruptions in normal blood flow, platelet aggregation and activation, and eventually end-organ damage due to circulatory failure...
  36. Functional Genomics of Platelet Aggregation Using iPS and Derived Megakaryocytes
    Linzhao Cheng; Fiscal Year: 2013
    ..In our GWAS study of native platelet aggregation and aggregation in response to low dose aspirin (GeneSTAR, Genetic Study of Aspirin Responsiveness), 64 ..
  37. Calpain-1 Signaling Pathways in Platelets
    Athar H Chishti; Fiscal Year: 2012
    ..signaling, reveal novel aspects of PTP1B regulation, and provide a better understanding of the mechanism of platelet aggregation and clot retraction pathways...
  38. Multiscale modeling of blood flow and clotting in cardiovascular devices
    Danny Bluestein; Fiscal Year: 2012
    ..model of flow induced thrombogenicity;incorporating biochemical and cellular reaction kinetics leading to platelet aggregation, clot formation and embolization...
  39. Variation in platelet function: the genetics of platelet gene expression
    Paul F Bray; Fiscal Year: 2013
    ..genome wide scan and platelet RNA expression studies have elucidated mechanisms for epinephrine-induced platelet aggregation, identified mRNA expression differences, as well as unexpected evidence that microRNAs (miRNAs) regulate ..
  40. Structural Studies of Triple-Helical Proteins
    BARBARA M BRODSKY; Fiscal Year: 2013
    ..within the bacterial collagen domain a human collagen platelet binding site requiring hydroxylation for platelet aggregation activity and a collagenase cleavage site requiring heterotrimers for activity...
  41. Structure Analysis of Integrin Activation
    MARK JAY YEAGER; Fiscal Year: 2010
    ..A key event that stimulates thrombus formation is platelet aggregation, which is mediated by the prototypical integrin aIIb[unreadable]3...
  42. Biomedical and Functional Studies of CD39
    AARON JACOB MARCUS; Fiscal Year: 2011
    ..This abolishes aggregation and recruitment. Recombinant, soluble human CD39 (solCD39) blocks human platelet aggregation in vitro, and inhibits porcine and murine platelet aggregation ex vivo...
  43. Molecular Mechanism of Platelet Dense Granule Biogenesis
    SANTIAGO MAURO DI PIETRO; Fiscal Year: 2013
    ..has been associated with disorders that manifest with moderate to severe mucocutaneous bleeding, excessive platelet aggregation is a major cause of morbidity and mortality due to its effect in myocardial infarction and stroke...
  44. Regulation of the Serotonin Transporter Function by Integrins in the Mouse Brain
    ANA MARIN DIAS CARNEIRO; Fiscal Year: 2013
    ..3 polymorphism Leu33Pro is associated with cardiovascular disease due to enhanced integrin signaling and platelet aggregation. This ?3 variant is also associated with hyperserotonemia in autistic patients, due to its upregulation of ..
  45. Non-Heme Iron-Nitrosyl Complexes: Their Structures and Nitric Oxide Release Kinet
    Lijuan Li; Fiscal Year: 2013
    ..of nitric oxide and its metal complexes, some of which include controlling blood pressure, preventing platelet aggregation, acting as biological messengers and immune system cytotoxic agents, and involving in long-term memory...
  46. Phase 1/2 of Taurine in Cystathionine Beta-Synthase Deficient Homocystinuria
    Johan L Van Hove; Fiscal Year: 2013
    ..Additionally, we will investigate the relevance of these biomarkers to pathogenesis by studies of platelet aggregation, endothelial dysfunction, and bone mineral density...
  47. Mechanisms of Platelet Activation in Depression and Acute Coronary Syndromes
    Marlene S Williams; Fiscal Year: 2013
    ..Our own pilot work has shown that depressed mood is associated with enhanced 5-HT activated platelet aggregation in patients with ACS...
  48. Randomized trial of sertraline treatment of depression in Chronic Kidney Disease
    SUSAN HEDAYATI; Fiscal Year: 2013
    ..side effects reported on the Frequency, Intensity and Burden of Side Effects Rating scale;d) reduction in platelet aggregation and activation from baseline in the sertraline as compared with placebo group, and whether this reduction ..
  49. The complement system links platelet activation to inflammation
    Rolando E Rumbaut; Fiscal Year: 2013
    ..Ex vivo experiments involve measures of platelet aggregation, and protocols to distinguish intrinsic platelet defects from effects due to complement factor deposition ..
  50. POINT: Platelet-Oriented Inhibition in New TIA
    Yuko Y Palesch; Fiscal Year: 2013
    ..However, no large-scale trial has evaluated an acute intervention in patients with TIA. Platelet aggregation is an important contributing factor in cerebral ischemia, as in other forms of ischemia...
  51. Platelet glycoprotein VI dependent microparticle formation
    Jerry Ware; Fiscal Year: 2012
    ..Stimulation of platelets with fibrillar collagen leads to platelet aggregation and a dramatic release of platelet microparticles (platelet fragments of less than 1 m)...
  52. Mechanisms of Integrin Receptor Transmembrane Signaling
    TOBIAS SEBASTIAN ULMER; Fiscal Year: 2012
    ..Integrin ?IIb-?3 mediates blood platelet aggregation and, as such, is a key regulator of thrombosis...
  53. Pharmacogenomics of Anti-platelet Response
    Rehan Qayyum; Fiscal Year: 2013
    ..variant at rs12041331 locus in the intron1 of the PEAR1 gene that is associated with native and post-ASA platelet aggregation and increased PEAR1 protein levels in platelets...
  54. Targeting mechanisms of cGMP dependent protein kinases by peptide arrays and crys
    CHOEL WOONG KIM; Fiscal Year: 2013
    ..cGMP-dependent protein kinase (PKG) is the central enzyme of NO-cGMP signaling pathway that regulates platelet aggregation, smooth muscle tone, phototransduction, and leukocyte migration [1,2]...
  55. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2013 aggregate more readily, and elevating plasma 5HT in vivo appears to trigger platelet 5HT depletion and platelet aggregation. This project by a new investigator is designed to define the biochemical mechanisms by which elevated 5HT ..
    David Williams; Fiscal Year: 2009
    ..Recently, zoanthenol has demonstrated specific inhibition of collagen-induced platelet aggregation. Part III (a). Australifungin...
  57. Structure and function of beta3 integrins on blood cells
    EDWARD FRANKLIN PLOW; Fiscal Year: 2013 turn, provide insights into the complex and biologically important responses of these cells, including platelet aggregation, thrombosis, cell homing and angiogenesis...
  58. Endogenous suppression of integrin signaling
    Ulhas P Naik; Fiscal Year: 2013
    ..such as signaling by various physiological agonists, override the anti-stimulatory machinery to achieve platelet aggregation. We have identified a novel protein named JAM-A, which is expressed on platelets and negatively regulates ..
  59. Ask1 a novel regulator of platelet function
    Ulhas P Naik; Fiscal Year: 2013
    ..For this reason, understanding the mechanisms surrounding platelet aggregation is essential. Platelet function is tightly regulated by both pro- and anti-stimulatory mechanisms...
  60. Reducing Tunneled Dialysis Catheter Dysfunction through Nitric Oxide Release
    Prabir Roy-Chaudhury; Fiscal Year: 2013
    ..Nitric oxide (NO) is an important biological mediator, which has potent anti-bacterial, anti-platelet aggregation and anti-smooth muscle cell proliferation activities, which could potentially reduce TDC complications...
  61. Mapping The Domain Architecture And Conformations of Soluble Guanylate Cyclase
    ERIC STEVEN UNDERBAKKE; Fiscal Year: 2012
    ..diverse physiological functions, including vasodilation, neurotransmission, myocardial function, and platelet aggregation. Soluble guanylate cyclase (sGC) is the primary receptor of NO...
  62. Functional Role of Protein Disulfide Isomerase Isoforms in Platelets
    David W Essex; Fiscal Year: 2013
    ..We found that PDI mediates platelet aggregation, and intravascular PDI has been shown to be required for thrombus formation...
  63. Regulation of integrin function by divalent cations
    Edward Plow; Fiscal Year: 2004
    ..At a molecular level, platelet aggregation depends upon the binding of adhesive ligands, such as the plasma protein fibrinogen, to the major membrane ..
    Jose Lopez; Fiscal Year: 2000
    ..This interaction is also induced in the fluid phase by high shear forces and may result in platelet aggregation in regions of arterial stenosis...
    Thomas Walker; Fiscal Year: 1990
    ..cells directly regulate or secrete products that regulate vascular tone and permeability, thrombosis, platelet aggregation, immune responsiveness and leukocyte margination...
    MARK HERZBERG; Fiscal Year: 1992
    ..the class I antigen, an adhesin, and the class II antigen a collagen-like immunodeterminant that induces platelet aggregation. Some strains also show sufficient class III activity, a presumptive ecto-ATPase...
    JOEL BENNETT; Fiscal Year: 1999
    Platelets provide for primary hemostasis by aggregating at sites of vascular injury. Moreover, platelet aggregation on abnormal vessels is responsible for the thrombosis characteristic of arterial vascular disease...