blood coagulation

Summary

Summary: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.

Top Publications

  1. doi Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
    Joanne van Ryn
    Department of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    Thromb Haemost 103:1116-27. 2010
  2. pmc TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation
    Huanghe Yang
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 94143, USA
    Cell 151:111-22. 2012
  3. ncbi The cytoprotective protein C pathway
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine MEM 180, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Blood 109:3161-72. 2007
  4. ncbi The interactions between inflammation and coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Br J Haematol 131:417-30. 2005
  5. doi Mechanisms of thrombus formation
    Bruce Furie
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA
    N Engl J Med 359:938-49. 2008
  6. doi Activation of blood coagulation in plasma from chronic urticaria patients with negative autologous plasma skin test
    R Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
    J Eur Acad Dermatol Venereol 25:201-5. 2011
  7. ncbi Novel pathway of iron‑induced blood coagulation: implications for diabetes mellitus and its complications
    Boguslaw Lipinski
    Joslin Diabetes Center, Harvard Medical School, Boston 02215, USA
    Pol Arch Med Wewn 122:115-22. 2012
  8. doi Inflammation and coagulation
    Marcel Levi
    Department of Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
    Crit Care Med 38:S26-34. 2010
  9. pmc Molecular intercommunication between the complement and coagulation systems
    Umme Amara
    Department of Traumatology, Hand, Plastic and Reconstructive Surgery, University Hospital of Ulm, Ulm, Germany
    J Immunol 185:5628-36. 2010
  10. pmc Platelet alpha-granules: basic biology and clinical correlates
    Price Blair
    Department of Medicine, Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Blood Rev 23:177-89. 2009

Detail Information

Publications414 found, 100 shown here

  1. doi Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
    Joanne van Ryn
    Department of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    Thromb Haemost 103:1116-27. 2010
    ....
  2. pmc TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation
    Huanghe Yang
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 94143, USA
    Cell 151:111-22. 2012
    Collapse of membrane lipid asymmetry is a hallmark of blood coagulation. TMEM16F of the TMEM16 family that includes TMEM16A/B Ca(2+)-activated Cl(-) channels (CaCCs) is linked to Scott syndrome with deficient Ca(2+)-dependent lipid ..
  3. ncbi The cytoprotective protein C pathway
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine MEM 180, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Blood 109:3161-72. 2007
    ....
  4. ncbi The interactions between inflammation and coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Br J Haematol 131:417-30. 2005
    ..When the inflammation-coagulation interactions overwhelm the natural defence systems, catastrophic events occur, such as manifested in severe sepsis or inflammatory bowel disease...
  5. doi Mechanisms of thrombus formation
    Bruce Furie
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA
    N Engl J Med 359:938-49. 2008
  6. doi Activation of blood coagulation in plasma from chronic urticaria patients with negative autologous plasma skin test
    R Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
    J Eur Acad Dermatol Venereol 25:201-5. 2011
    ..Immune-mediated inflammation and coagulation are strictly linked, and coagulation activation has been described in CU patients as shown by the elevation of plasma prothrombin fragment F1+2 and, in severe cases, of d-dimer as well...
  7. ncbi Novel pathway of iron‑induced blood coagulation: implications for diabetes mellitus and its complications
    Boguslaw Lipinski
    Joslin Diabetes Center, Harvard Medical School, Boston 02215, USA
    Pol Arch Med Wewn 122:115-22. 2012
    ..Thus, we postulate that this iron-catalyzed reaction represents a novel blood coagulation pathway operating in degenerative diseases...
  8. doi Inflammation and coagulation
    Marcel Levi
    Department of Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
    Crit Care Med 38:S26-34. 2010
    ..Conversely, activated coagulation proteases may affect specific cellular receptors on inflammatory cells and endothelial cells and thereby modulate the inflammatory response...
  9. pmc Molecular intercommunication between the complement and coagulation systems
    Umme Amara
    Department of Traumatology, Hand, Plastic and Reconstructive Surgery, University Hospital of Ulm, Ulm, Germany
    J Immunol 185:5628-36. 2010
    ....
  10. pmc Platelet alpha-granules: basic biology and clinical correlates
    Price Blair
    Department of Medicine, Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Blood Rev 23:177-89. 2009
    ..This review will consider the formation, release, and physiologic roles of alpha-granules with special emphasis on work performed over the last decade...
  11. ncbi Direct thrombin inhibitors
    Marcello Di Nisio
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    N Engl J Med 353:1028-40. 2005
  12. ncbi Protease-activated receptors in hemostasis, thrombosis and vascular biology
    S R Coughlin
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    J Thromb Haemost 3:1800-14. 2005
    ....
  13. doi Interaction of fibrin with red blood cells: the role of iron
    Boguslaw Lipinski
    Harvard Medical School, Boston, Massachusetts, USA
    Ultrastruct Pathol 36:79-84. 2012
    ..It is suggested that future research on prevention and treatment of ischemic stroke and other thrombosis associated diseases should include testing of iron-chelating and hydroxyl radical-scavenging agents...
  14. ncbi Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
    J Allergy Clin Immunol 119:705-10. 2007
    ..In patients with chronic urticaria (CU), plasma shows signs of thrombin generation and autologous plasma skin tests score positive in as many as 95% of cases...
  15. doi Coagulation and innate immune responses: can we view them separately?
    Mieke Delvaeye
    Vesalius Research Center, University of Leuven, Belgium
    Blood 114:2367-74. 2009
    ..We attempt to highlight the potential impact of these findings by identifying recently established paradigms that will hopefully result in the emergence of new strategies to treat a range of inflammatory and hemostatic disorders...
  16. doi Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
    Joachim Stangier
    Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse, Biberach an der Riss, Germany
    Clin Appl Thromb Hemost 15:9S-16S. 2009
    ....
  17. pmc Anticoagulants and the propagation phase of thrombin generation
    Thomas Orfeo
    Department of Biochemistry, University of Vermont, Colchester, Vermont, United States of America
    PLoS ONE 6:e27852. 2011
    ..More generally, the study shows that computational modeling of the response of core elements of the coagulation proteome to a physiologically relevant tissue factor stimulus may improve the monitoring of a broad range of anticoagulants...
  18. ncbi Statins and blood coagulation
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Arterioscler Thromb Vasc Biol 25:287-94. 2005
    ..There is growing evidence that treatment with statins can lead to a significant downregulation of the blood coagulation cascade, most probably as a result of decreased tissue factor expression, which leads to reduced thrombin ..
  19. ncbi The significance of circulating factor IXa in blood
    Saulius Butenas
    Department of Biochemistry, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Biol Chem 279:22875-82. 2004
    ....
  20. doi A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries
    Amy J Plotkin
    Pittsburgh Tissue Engineering Initiative, Pittsburgh, Pennsylvania, USA
    J Trauma 64:S64-8. 2008
    ..We hypothesized that TEG data would aid in defining the coagulopathy of trauma in patients with penetrating traumatic injuries...
  21. ncbi A brief historical review of the waterfall/cascade of blood coagulation
    Earl W Davie
    Department of Biochemistry, University of Washington, Seattle, Washington 98195 7350, USA
    J Biol Chem 278:50819-32. 2003
  22. ncbi Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis
    Nigel Mackman
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Code SP30 3040, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 27:1687-93. 2007
    ..The traditional view of the regulation of blood coagulation is that the initiation phase is triggered by the extrinsic pathway, whereas amplification requires the ..
  23. ncbi Bidirectional relation between inflammation and coagulation
    Marcel Levi
    Department of Internal Medicine F 4, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 109:2698-704. 2004
  24. pmc Innate immunity and coagulation
    C T Esmon
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Thromb Haemost 9:182-8. 2011
    ..Such a complex response to infection presumably arises due to the role of coagulation in the control and clearance of the infectious agent...
  25. pmc Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation
    Christian Kannemeier
    Research Laboratories, Aventis Behring, D 35392 Marburg, Germany
    Proc Natl Acad Sci U S A 104:6388-93. 2007
    ..derived from damaged cells at these sites will become exposed to blood components and could contribute to blood coagulation and pathological thrombus formation...
  26. ncbi In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
    Wolfgang Wienen
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse, 88397 Biberach, Germany
    Thromb Haemost 98:155-62. 2007
    ..These data suggest that dabigatran is a potent, selective thrombin inhibitor and an orally active anticoagulant as the prodrug, dabigatran etexilate...
  27. pmc Blood hypomethylation of inflammatory genes mediates the effects of metal-rich airborne pollutants on blood coagulation
    Letizia Tarantini
    Department of Clinical and Community Sciences, Università degli Studi di Milano and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Occup Environ Med 70:418-25. 2013
    ..DNA methylation is an environmentally sensitive mechanism of gene regulation that could potentially contribute to PM-induced hypercoagulability. We aimed to test whether altered methylation mediates environmental effects on coagulation...
  28. pmc Oxidation inhibits iron-induced blood coagulation
    Etheresia Pretorius
    Department of Physiology, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South Africa
    Curr Drug Targets 14:13-9. 2013
    b>Blood coagulation under physiological conditions is activated by thrombin, which converts soluble plasma fibrinogen (FBG) into an insoluble clot...
  29. pmc Defective thrombus formation in mice lacking coagulation factor XII
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    J Exp Med 202:271-81. 2005
    b>Blood coagulation is thought to be initiated by plasma protease factor VIIa in complex with the membrane protein tissue factor...
  30. doi Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects
    Elise S Eerenberg
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Circulation 124:1573-9. 2011
    ..This study evaluated the potential of prothrombin complex concentrate (PCC) to reverse the anticoagulant effect of these drugs...
  31. ncbi Cross-talk between inflammation,coagulation/fibrinolysis and vascular access in hemodialysis patients
    E Costa
    Instituto de Ciências da Saúde da Universidade Católica Portuguesa, Porto, Portugal
    J Vasc Access 9:248-53. 2008
    ..The increased levels of Ddimer, tPA and inflammatory markers in CKD patients using a CVC, led us to propose a relationship between the type of VA chosen for HD, and the risk of thrombogenesis...
  32. pmc Evaluation of marine brown algae and sponges from Brazil as anticoagulant and antiplatelet products
    Laura de Andrade Moura
    Department of Molecular and Cellular Biology, Institute of Biology, Federal Fluminense University, Niteroi, 24020 141 RJ, Brazil
    Mar Drugs 9:1346-58. 2011
    The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects...
  33. doi Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    Alexey A Schramko
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
    Anesth Analg 108:30-6. 2009
    There is continuing concern about the effect of hydroxyethyl starch (HES) solutions on blood coagulation. Rapidly degradable HES solutions with more favorable effects on clot strength have therefore been developed...
  34. pmc Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation
    Jie Meng
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    PLoS ONE 7:e38995. 2012
    ..It was concluded that the four MWCNTs affected blood coagulation process and the clots mechanical properties; they also altered the integrity of the red blood cells and the ..
  35. doi First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study
    Klaus Görlinger
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 115:1179-91. 2011
    ..We developed and implemented an algorithm for coagulation management in cardiovascular surgery based on first-line administration of coagulation factor concentrates combined with point-of-care thromboelastometry/impedance aggregometry...
  36. doi Functional characteristics of N8, a new recombinant FVIII
    M L S Christiansen
    Biopharmaceutical Research Unit, Novo Nordisk A S, Måløv, Denmark
    Haemophilia 16:878-87. 2010
    ..The study demonstrated that N8 is fully functional in a variety of assays measuring FVIII activity. No functional differences were found between N8 and comparator compounds...
  37. doi The coagulation system and pulmonary endothelial function in acute lung injury
    James H Finigan
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Microvasc Res 77:35-8. 2009
    ....
  38. pmc Nanostructure of the fibrin clot
    C Yeromonahos
    Centre National de la Recherche Scientifique, Universite Joseph Fourier, Grenoble, France
    Biophys J 99:2018-27. 2010
    ..Further, although the fibers are locally crystalline, they appear to possess a lateral fractal structure...
  39. ncbi Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
    Jochen Graff
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, University Hospital, Frankfurt Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Clin Pharmacol 47:1398-407. 2007
    ..Rivaroxaban strongly inhibits platelet-induced thrombin generation, after activation of either platelets or the coagulation pathway, even in the presence of minimal factor Xa inhibition in plasma...
  40. pmc Association of coagulation activation with clinical complications in sickle cell disease
    Kenneth I Ataga
    Division of Hematology Oncology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e29786. 2012
    ..We sought to evaluate the association of markers of coagulation and platelet activation with specific clinical complications and laboratory variables in patients with SCD...
  41. doi Activation of coagulation by a thalidomide-based regimen
    Asuka Hoshi
    Laboratory Molecular Genetics of Hematology, Graduate School of Healthcare Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Blood Coagul Fibrinolysis 22:532-40. 2011
    ..Induction may be protracted by Thal, which has an antiangiogenic activity. Therefore, prophylactic anticoagulant strategies should be considered in Thal-based combination regimens...
  42. doi Hemoconcentration and hemostasis during acute stress: interacting and independent effects
    Anthony W Austin
    Department of Psychology, Ohio University, Athens, OH, USA
    Ann Behav Med 42:153-73. 2011
    ..It is unclear whether these effects are independent or have influence on each other...
  43. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  44. ncbi Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
    Joachim Stangier
    Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
    Clin Pharmacokinet 47:47-59. 2008
    ....
  45. doi Inflammation and coagulation. An overview
    Jari Petaja
    Director, Department of Pediatrics and Gynecology Helsinki University Central Hospital, Finland
    Thromb Res 127:S34-7. 2011
    ..Animal experiments with signaling selective APC-variants show promise in improving the therapeutic efficacy and safety of APC in sepsis...
  46. doi The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation
    Sonia Philipose
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, A 8010 Graz, Austria
    Arterioscler Thromb Vasc Biol 30:2416-23. 2010
    ..The platelet-stimulating effect of PGE(2) has been suggested to involve EP3 receptors. Here we analyzed the receptor usage relating to the inhibitory effect of PGE(2)...
  47. pmc Role of cellular elements in thrombus formation and dissolution
    N Wohner
    Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary 1088, Puskin u 9, Hungary
    Cardiovasc Hematol Agents Med Chem 6:224-8. 2008
    ..Leukocyte-derived enzymes, first of all elastase, effect fibrinolysis by direct digestion of fibrin or indirectly modulate it by partial degradation of zymogens and inhibitors of coagulation and fibrinolytic proteases...
  48. doi Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure
    Hiromi Nabeshi
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Nanotechnology 23:045101. 2012
    ..These results would provide useful information for ensuring the safety of nanomaterials (NMs) and open new frontiers in biological fields by the use of NMs...
  49. doi Inherited antithrombin deficiency: a review
    M M Patnaik
    Department of Internal Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Haemophilia 14:1229-39. 2008
    Antithrombin (AT) is a potent inactivator of thrombin and factor Xa and the major inhibitor of blood coagulation. Inherited AT deficiencies are uncommon, with prevalences in the general population between 1 in 500 and 1 in 5000...
  50. doi Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation
    Hsi Ju Wei
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Cardiovasc Res 92:317-27. 2011
    ..Thrombomodulin (TM) inhibits thrombin effects by binding thrombin through its domains 2 and 3 (TMD23). We investigated whether recombinant TMD23 (rTMD23) could inhibit atherosclerosis via its thrombin-binding ability...
  51. doi Early atherosclerosis exhibits an enhanced procoagulant state
    Julian Ilcheff Borissoff
    Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Universiteitsingel 50, PO Box 616, Box 8, 6200 MD Maastricht, The Netherlands
    Circulation 122:821-30. 2010
    ..In the present study, we examined for the first time the activity and presence of relevant coagulation proteins in relation to the progression of atherosclerosis...
  52. ncbi Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke
    Nozomi Nishimura
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    Nat Methods 3:99-108. 2006
    ..This demonstrates that a single blockage to a microvessel can lead to local cortical ischemia. Lastly, we show that hemodilution leads to a restoration of flow in secondary downstream vessels...
  53. doi A prospective study of an aggressive warfarin dosing algorithm to reach and maintain INR 2 to 3 after heart valve surgery
    Karina Meijer
    Division of Haemostasis and Thrombosis, Department of Haematology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 105:232-8. 2011
    ..We demonstrate an improvement of the level of anticoagulation control with the use of a condition-specific, aggressive algorithm, as compared to standard dosing, in patients after heart valve surgery...
  54. pmc Anticoagulation by factor Xa inhibitors
    T Orfeo
    Department of Biochemistry, University of Vermont, Colchester, VT, USA
    J Thromb Haemost 8:1745-53. 2010
    Therapeutic agents that regulate blood coagulation are critical to the management of thrombotic disorders, with the selective targeting of factor (F) Xa emerging as a promising approach.
  55. ncbi Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients
    Liyan Miao
    Department of Clinical Pharmacology Research Lab, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    Eur J Clin Pharmacol 63:1135-41. 2007
    ..The objective of this study was to assess the contribution of the VKORC1 and CYP2C9 genotypes and age, body size, and weight of the patients to the warfarin dose requirement in a Chinese population...
  56. doi New oral anticoagulants in development
    Jeffrey I Weitz
    Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
    Thromb Haemost 103:62-70. 2010
    ..This paper focuses on the new oral anticoagulants in the most advanced stages of development...
  57. pmc Simultaneous activation of complement and coagulation by MBL-associated serine protease 2
    Anders Krarup
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 2:e623. 2007
    ..These findings suggest that, as has been proposed for invertebrates, limited clotting may contribute to the innate immune response...
  58. pmc Structure of human factor VIIa and its implications for the triggering of blood coagulation
    A C Pike
    Structural Biology Laboratory, Chemistry Department, University of York, York YO10 5DD, United Kingdom
    Proc Natl Acad Sci U S A 96:8925-30. 1999
    Factor VIIa (EC 3.4.21.21) is a trypsin-like serine protease that plays a key role in the blood coagulation cascade. On injury, factor VIIa forms a complex with its allosteric regulator, tissue factor, and initiates blood clotting...
  59. pmc Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water
    Andre E X Brown
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 325:741-4. 2009
    ....
  60. ncbi A role for Hemolectin in coagulation and immunity in Drosophila melanogaster
    Christine Lesch
    Department of Molecular Biology and Functional Genomics, University of Stockholm, Svante Arrhenius Väg 16 18, 10691 Stockholm, Sweden
    Dev Comp Immunol 31:1255-63. 2007
    ..This demonstrates an immunological role of this clotting protein and reinforces the importance of the clot in insect immunity...
  61. doi The systemic pro-inflammatory response in sepsis
    Hanna Katrien de Jong
    Center for Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Innate Immun 2:422-30. 2010
    ....
  62. pmc In-traffic air pollution exposure and CC16, blood coagulation, and inflammation markers in healthy adults
    Moniek Zuurbier
    Public Health Services Gelderland Midden, Arnhem, The Netherlands
    Environ Health Perspect 119:1384-9. 2011
    ..Little is known about effects of the short exposures encountered while participating in traffic...
  63. doi Prolonged activity of factor IX as a monomeric Fc fusion protein
    Robert T Peters
    Molecular and Cell Biology, Biogen Idec Hemophilia, 9 Fourth Ave, Waltham, MA 02451, USA
    Blood 115:2057-64. 2010
    ..Taken together, these studies show the enhanced pharmacodynamic and pharmacokinetic properties of the rFIXFc fusion protein and provide the basis for evaluating rFIXFc in patients with hemophilia B...
  64. doi Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor
    Meyer Michel Samama
    Hotel Dieu University Hospital, Paris, France 2Biomnis Laboratory, Ivry sur Seine, France
    Thromb Haemost 103:815-25. 2010
    ..Finally, all clotting and chromogenic assays showed a concentration-dependent effect induced by rivaroxaban...
  65. doi DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles
    T Furugohri
    Biological Research Laboratories I, R and D Division, Daiichi Sankyo Co, Ltd, Shinagawa ku, Toyo, Japan
    J Thromb Haemost 6:1542-9. 2008
    ..DU-176b is a novel antithrombotic agent that directly inhibits FXa activity...
  66. pmc Coagulation markers in healthy human subjects exposed to diesel exhaust
    Chris Carlsten
    Department of Medicine, University of Washington, 4225 Roosevelt Ave NE, University of Washington, Campus Box 354695, Seattle, WA 98195, United States
    Thromb Res 120:849-55. 2007
    ..Diesel exhaust is a major contributor to urban PM, and we conducted a controlled human exposure of diesel exhaust in healthy subjects...
  67. ncbi Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications
    Jan Steffel
    Cardiovascular Research, Physiology Institute, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Circulation 113:722-31. 2006
    ..Inhibition of TF action appears to be an attractive target for the treatment of cardiovascular diseases...
  68. doi An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy
    Gastroenterology 137:2105-11. 2009
    ..We investigated whether plasma from cirrhotic patients has an imbalance of pro- vs anti-coagulation factors...
  69. ncbi A model for the stoichiometric regulation of blood coagulation
    Matthew F Hockin
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 277:18322-33. 2002
    We have developed a model of the extrinsic blood coagulation system that includes the stoichiometric anticoagulants...
  70. ncbi Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol
    Iris Erlund
    Biomarker Laboratory, Department of Health and Functional Capacity, National Public Health Institute, Helsinki, Finland
    Am J Clin Nutr 87:323-31. 2008
    ..Whether the consumption of berries has similar effects is unknown...
  71. ncbi Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation fa
    Donald J P Pinto
    Discovery Chemistry, Research and Development, Bristol Myers Squibb Company, 31 Pennington Rocky Hill Road, Pennington, New Jersey 08534, USA
    J Med Chem 50:5339-56. 2007
    ..Compound 40 exhibits a high degree of fXa potency, selectivity, and efficacy and has an improved pharmacokinetic profile relative to 4...
  72. ncbi Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity
    R Leung
    Division of Haematology, Oncology and Physiology and Experimental Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada
    J Thromb Haemost 5:560-70. 2007
    ..PS expression, associated with apoptosis in nucleated cells, would be expected to be reversed by aminophospholipid translocase (APLT) activity...
  73. ncbi Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure
    Hirokazu Ueno
    Department of Emergency and Critical Care Medicine, Chiba University School of Medicine, Japan
    Crit Care Med 30:2242-8. 2002
    ....
  74. ncbi Heritability of clot formation, morphology, and lysis: the EuroCLOT study
    Angela M Carter
    Academic Unit of Molecular Vascular Medicine, The LIGHT Laboratories, University of Leeds Leeds LS2 9JT, UK
    Arterioscler Thromb Vasc Biol 27:2783-9. 2007
    ....
  75. ncbi Blood coagulation and fibrinolytic activity in hypothyroidism
    C Erem
    Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
    Int J Clin Pract 57:78-81. 2003
    ..However, thyroid hormones may play a role at different levels of the complex haemostatic system...
  76. ncbi Engineering design of optimal strategies for blood clot dissolution
    S L Diamond
    Institute for Medicine and Engineering, Department of Chemical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Biomed Eng 1:427-62. 1999
    ..These principles also impact the design and analysis of local delivery devices...
  77. pmc Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults
    Donald W Graff
    MDS Pharma Services, Lincoln, Nebraska, USA
    Environ Health Perspect 117:1089-94. 2009
    ..There is less certainty as to the contribution of coarse PM (PM(2.5-10)), which derives from crustal materials and from mechanical processes, to mortality and morbidity...
  78. doi Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation
    Frank Niessen
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 452:654-8. 2008
    ..Thus, activation of dendritic cells by coagulation in the lymphatics emerges as a previously unknown mechanism that promotes systemic inflammation and lethality in decompensated innate immune responses...
  79. ncbi Assessment of the heparin-binding AN69 ST hemodialysis membrane: II. Clinical studies without heparin administration
    Sylvie Lavaud
    Service de Nephrologie, Centre Hospitalier et Universitaire and CNRS FRE 2534, Reims, France
    ASAIO J 51:348-51. 2005
    ..It is concluded that the dialysis AN69 ST membrane, after adequate priming at bedside, can be used without systemic administration of heparin for hemodialysis in patients at high risk of bleeding...
  80. doi Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension
    Kenneth I Ataga
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, CB 7305, 3009 Old Clinic Bldg Chapel Hill, NC 27599 7305, USA
    Haematologica 93:20-6. 2008
    ..Pulmonary hypertension (PHT) is common in sickle cell disease (SCD). The purpose of this study was to determine whether markers of coagulation activation and inflammation are associated with PHT in SCD...
  81. ncbi The molecular basis of blood coagulation
    B Furie
    Department of Medicine, New England Medical Center, Boston, Massachusetts
    Cell 53:505-18. 1988
  82. ncbi Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation
    Bruce Furie
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Trends Mol Med 10:171-8. 2004
    ..both tissue factor and PSGL-1, circulate in the blood and accumulate in the developing platelet-rich thrombus following vessel wall injury, thus concentrating tissue factor at the site of vascular injury and initiating blood coagulation.
  83. doi Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, 89 Commercial Road, Melbourne, Victoria 3004, Australia
    Blood 114:663-6. 2009
    ..These studies show the existence of 2 distinct pathways regulating the procoagulant function of platelets...
  84. ncbi Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms
    Robert A S Ariens
    Academic Unit of Molecular Vascular Medicine, University of Leeds School of Medicine, United Kingdom
    Blood 100:743-54. 2002
    ..In this review, we have summarized recent findings on the structure and function of factor XIII. This is followed by a review of the effects of genetic polymorphisms on protein structure/function and their relationship to disease...
  85. pmc Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
    Kazue Takahashi
    Developmental Immunology Program, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunobiology 216:96-102. 2011
    ..Infected MBL null mice also develop liver injury. These findings suggest that MBL deficiency may manifest into DIC and organ failure during infectious diseases...
  86. doi Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate
    Jonathan Douxfils
    Department of Pharmacy, Namur Thrombosis and Hemostasis Center NTHC, NAmur Research Institute for LIfe Sciences NARILIS, University of Namur, Belgium
    Thromb Haemost 107:985-97. 2012
    ..However, because of its higher sensitivity, good reproducibility, excellent linear correlation at all doses, its simplicity of use, and possibilities of automation, HTI should be considered as the gold-standard...
  87. ncbi Complement and coagulation: strangers or partners in crime?
    Maciej M Markiewski
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Trends Immunol 28:184-92. 2007
    ..Here, we review the interactions of the complement system with hemostasis and their roles in various diseases...
  88. ncbi Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation
    R J Berckmans
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands
    Thromb Haemost 85:639-46. 2001
    ..We conclude that microparticles in blood from healthy individuals support thrombin generation via TF- and FVII-independent pathways, and which may have an anticoagulant function...
  89. ncbi Exposure of platelet membrane phosphatidylserine regulates blood coagulation
    Barry R Lentz
    Department of Biochemistry and Biophysics, CB7260, University of North Carolina at Chapel Hill, USA
    Prog Lipid Res 42:423-38. 2003
    ..phosphatidylserine (PS) in regulating the production of thrombin, the central regulatory molecule of blood coagulation. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the plasma-..
  90. pmc Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
    Matthew J Flick
    Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:1596-606. 2004
    ....
  91. pmc Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees
    T van der Poll
    Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Exp Med 179:1253-9. 1994
    ..IL-6 is, however, an important intermediate factor in activation of coagulation in low grade endotoxemia in chimpanzees...
  92. ncbi Signaling of the tissue factor coagulation pathway in angiogenesis and cancer
    Mattias Belting
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 25:1545-50. 2005
    ..Here we review the molecular mechanisms of tissue factor pathways in angiogenesis and tumorigenesis with emphasis on the intriguing role for tissue factor cytoplasmic domain signaling...
  93. ncbi The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults
    Kai Jen Chuang
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taiwan
    Am J Respir Crit Care Med 176:370-6. 2007
    ..The biological mechanisms linking air pollution to cardiovascular events still remain largely unclear...
  94. doi The direct thrombin inhibitor hirudin
    Andreas Greinacher
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald, Sauerbruchstrasse, 17489 Greifswald, Germany
    Thromb Haemost 99:819-29. 2008
    ..Drawbacks of hirudin and important precautions for avoiding potential adverse effects are discussed in detail in the third part of this review...
  95. ncbi Fibrinogen-binding proteins of Gram-positive bacteria
    Jose Rivera
    CEMB, Institute of Biosciences and Technology, 2121 W Holcombe, Houston, Texas 77030, USA
    Thromb Haemost 98:503-11. 2007
    Fibrinogen (Fg), the major clotting protein in blood plasma, plays key roles in blood coagulation and thrombosis...
  96. ncbi Voluven, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200/0.5
    O Langeron
    , , Paris, France
    Anesth Analg 92:855-62. 2001
    ....
  97. pmc Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis
    S Lindemann
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 154:485-90. 2001
    ....
  98. ncbi A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways
    Konstantinos Ritis
    First Division of Internal Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
    J Immunol 177:4794-802. 2006
    ..C5a receptors in neutrophils leads to the induction of tissue factor (TF), a key initiating component of the blood coagulation cascade...
  99. ncbi The impact of the inflammatory response on coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, OK, USA
    Thromb Res 114:321-7. 2004
    ..Inflammation impacts the initiation, propagation and the inhibitory phases of blood coagulation. Inflammatory mediators like endotoxin and tumor necrosis factor alpha (TNF alpha) elicit the expression of ..
  100. ncbi Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin
    Brian F Gage
    Department of Medicine, Washington University School of Medicine Campus Box 8005, 660 S Euclid Ave St Louis, Missouri 63110, USA
    Thromb Haemost 91:87-94. 2004
    ..001). In conclusion, the maintenance warfarin dose can be estimated from demographic, clinical, and pharmacogenetic factors that can be obtained at the time of warfarin initiation...
  101. ncbi Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation
    Gregor Hron
    Department of Internal Medicine I, Medical University of Vienna, Austria
    JAMA 296:397-402. 2006
    ..Because of the large number of risk factors, assessing the risk of recurrence in an individual patient is complex. A method covering multicausal thrombophilia is therefore required...

Research Grants69

  1. PRE- AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGY
    J Evan Sadler; Fiscal Year: 2013
    ..of the participating Mentors and include: pathogenesis of hemorrhagic and thrombotic disorders;regulation of blood coagulation and fibrinolysis;gene therapy of hemophilia and lysosomal storage diseases;phosphoinositide metabolism and ..
  2. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    ..application is that LDL receptor family members, especially LRP, play an important role in regulating the blood coagulation process by mediating the cellular catabolism of two key players, fVIII(a) and fIXa...
  3. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    ..mammalian tissues and is central to a wide-ranging array of physiological processes, including vasodilation, blood coagulation, memory formation, inflammation, angiogenesis, cell growth and cell death...
  4. Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
    Dana Boyd; Fiscal Year: 2013
    ..Human VKOR is a component of the blood coagulation pathway...
  5. GPCR Signaling &Vascular Wall Remodeling
    Gadiparthi N Rao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thrombin, a serine/threonine protease, besides its role in blood coagulation, plays a significant role as a mitogen and motogen to many cell types, in particular to vascular smooth muscle cells (..
  6. Tick feeding regulation by orthologous tick saliva serine protease inhibitors
    Albert Mulenga; Fiscal Year: 2013
    ..To complete feeding, ticks must overcome host defense reactions, blood coagulation, complement activation and inflammation, all of which are serine protease mediated pathways that are tightly ..
  7. Blood Coagulation Protein - Metal Ion - Lipid Interactions
    Francis J Castellino; Fiscal Year: 2013
    ..This proposal is concerned with the complex mechanisms of action of the conantokins in vitro and in vivo and relating these properties to their neuroprotective effects in a model of occlusive stroke. ..
  8. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013
    The vitamin K cycle supports blood coagulation and is a major target for anticoagulation drugs. Coagulation factors require Dcarboxylation of glutamic acids for activation at sites of injury...
  9. Smooth Muscle Cell Tissue Factor and Cardiovascular Disease
    Mark B Taubman; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This proposal examines the biology of tissue factor, the molecule that initiates blood coagulation. Tissue factor is thought to play a major role in coronary thrombosis, the leading cause of heart attacks, ..
  10. PROTEINS OF COAGULATION PATHWAYS
    John H Griffin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project involves basic and clinical research on regulation of blood coagulation and on venous thromboembolic disease (VTE)...
  11. MOLECULAR BASIS OF BLOOD COAGULATION REGULATION
    Steven T Olson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Serpin family protein protease inhibitors function as key regulators of blood coagulation proteases...
  12. Pathogenesis of Trypanosoma cruzi infection
    Roberto Docampo; Fiscal Year: 2013
    ..With the discovery of the potent modulatory activity of this polymer on blood coagulation and inflammation there has been renewed interest in this molecule as of potential importance in virulence of ..
  13. Deranged Coagulation and Fibrinolytic Cascades in Idiopathic Pulmonary Fibrosis
    MITCHELL ALAN OLMAN; Fiscal Year: 2013
    ..In support of the importance of further study of the blood coagulation/fibrinolysis system, patients with IPF have an increased risk of atherothrombosis-related clinical events, ..
  14. A diagnostic instrument to manage hemostasis in chronic liver disease
    Francesco Viola; Fiscal Year: 2012
    ..and transfusion of blood products: (i) Fresh frozen plasma (FFP) and/or cryoprecipitate to replenish blood coagulation proteins. (ii) Platelet concentrates to replenish platelets level...
  15. Molecular Genetic Study of von Willebrand Factor
    David Ginsburg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): von Willebrand factor (VWF) is a key component of the blood coagulation system. Deficiencies of VWF result in the most common inherited bleeding disorder in humans, von Willebrand disease (VWD)...
  16. Fibrinogen as a molecular mediator of cognitive dysfunction
    Frances Alexandra Loucks; Fiscal Year: 2010
    ..Fibrinogen, a critical component of blood coagulation, extravasates into the brain after vascular damage or BBB disruption...
  17. Self-Complementary AAV2 Factor IX for Hemophilia B
    SCOTT WILLIAM JOHN MCPHEE; Fiscal Year: 2010
    ..Reduced patient burden, non-compliance, and exposure to blood products are expected to correlate with reductions in morbidity and mortality - as well as a vastly improved quality of life for Hemophilia B patients in the U.S. alone. ..
  18. Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT)
    ANGARA KONETI RAO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Activation of the tissue factor (TF) pathway of blood coagulation is associated with increased blood thrombogenicity and increases in markers of blood coagulation levels may in part explain the high ..
  19. Protease Activated Receptor Signaling by Coagulation Proteases
    Alireza R Rezaie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coagulation proteases, in addition to their role in the regulation of blood coagulation, can modulate intracellular signaling events by activating a subfamily of G-protein coupled receptors named ..
  20. Structure and Stability Studies of Factor VIII to Overcome the Immune Response
    PAUL CLINTON SPIEGEL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Blood coagulation factor VIII is a non-enzymatic glycoprotein cofactor that is essential for proper regulation of the blood coagulation cascade...
  21. Post-Reductionist Protein Folding: Determining the In-cell Folding Energy Landsca
    Daniel N Hebert; Fiscal Year: 2013
    ..play crucial biological roles by regulating proteases involved in key physiological processes including blood coagulation and inflammation...
  22. Serine Proteinase Inhibitors (Serpins) in Tick Feeding and Physiology
    Albert Mulenga; Fiscal Year: 2009
    ..serpins are involved in regulation of important of proteolytic pathways that are essential to life such as blood coagulation with serpin malfunctions arising from natural mutations causing numerous debilitating diseases...
  23. The Activation of Prothrombin
    Kenneth G Mann; Fiscal Year: 2011
    The goal of this project is to characterizethe physiology and pathology of the blood coagulation system in quantifiable terms...
  24. Lipid Regulation of Thrombin Generation
    Barry R Lentz; Fiscal Year: 2012
    Thrombin, the central regulatory molecule of blood coagulation, is produced by prothrombin (II) proteolysis by a platelet-membrane-bound enzyme (factor Xa) and its associated cofactor (factor Va)...
  25. LRP structure and function
    Peter G W Gettins; Fiscal Year: 2013
    ..aberrant clearance of serum lipoproteins, and imbalance in the regulation of proteins associated with blood coagulation and inflammation of the artery wall...
  26. STEP UP In Health-related Research
    Raul DeLa Cadena; Fiscal Year: 2013
    ..such as 1) the Sol Sherry Thrombosis Research Center which focuses on research related to platelet function, blood coagulation, neutrophil activation and fibrin formation, 2) the Cardiovascular Research Center with research related to ..
  27. Mechanism of Staphylocoagulase-activated Blood Clotting
    Paul E Bock; Fiscal Year: 2012
    ..define the molecular mechanism by which the Staphylococcus aureus protein, staphylocoagulase (SC), activates blood coagulation, and its role in the pathology of acute bacterial endocarditis...
  28. Elucidating the Mechanism of Novel Dengue Antivirals
    Stanley Watowich; Fiscal Year: 2009
    ..the blood-clotting assay is prudent to ensure dengue protease inhibitors do not interfere with the blood coagulation cascade (Specific Aim 4)...
  29. Mechanisms of Immunogenicity of Factor VIII
    Shannon L Meeks; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Patients with hemophilia A have a deficiency in the blood coagulation protein factor VIII...
  30. Methods for generalized ontology terms enrichment analysis
    Nigam Shah; Fiscal Year: 2013
    ..identified a class of diseases - blood coagulation disorders - that are associated with a significant depletion in substitutions a O-linked glycosylation sites...
  31. Enabling high dose regional chemotherapy while minimizing systemic toxicity
    Shaker A Mousa; Fiscal Year: 2010
    ..Aim 2: Determine the blood biocompatibility of the different coated filters by a) measuring changes in blood coagulation parameters and b) measuring changes in platelet activation state...
  32. Novel Technologies for Imaging Blood Coagulation Reactions
    Sriram Krishnaswamy; Fiscal Year: 2010
    ..imaging approach to the next level and permit widely applicable studies to decipher the regulation of the blood coagulation pathways in vivo. CHOP contributes substantially to the local economy...
  33. Molecular, Structural &Clinical Aspects of Vitamin K-Dependent Proteins
    SARAH LOUISE BOOTH; Fiscal Year: 2011
    ..for its role in hemostasis, and requirements were historically based on the amount required for normal blood coagulation. In the past, the cohesiveness of the VK field was largely maintained by the focus on hemostasis...
  34. Roles for coagulation in immunity
    Stephen T Smiley; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Blood coagulation pathways culminate in the deposition of fibrin, an extracellular matrix that provides the structural scaffold for the blood clot and orchestrates wound repair...
  35. Activation of encrypted tissue factor during thrombus formation in vivo
    CAMERON TRENOR; Fiscal Year: 2012
    As a mechanism of host defense, the initiation of the blood coagulation cascade requires tight regulation both in its timing and location...
  36. Chemistry and Biology of Coagulation
    Sriram Krishnaswamy; Fiscal Year: 2013
    b>Blood coagulation derives from a series of specific proteolytic activation reactions that are catalyzed with narrow and defined specificity by trypsin-like serine proteinases...
  37. The Biochemistry and Physiology of Platelet TFPI
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..TFPI) is the major inhibitor of the tissue factor/factor Vila (TF/Vlla) catalytic complex that initiates blood coagulation. Therefore, TFPI is a potent anticoagulant protein...
  38. Effects of Hibernation on Hemostasis in 13-lined Ground Squirrels
    Scott T Cooper; Fiscal Year: 2012
    ..system may lead to medical advances to prevent DVT, store human platelets in the cold, and regulate blood coagulation in cases of accidental or induced hypothermia...
  39. Molecular interactions between soluable host factors and a gene delivery vector
    Vijay S Reddy; Fiscal Year: 2013
    ..Recently, it has been shown that association of species A and C HAdVs with several blood coagulation factors (e.g...
  40. Glycomics of Heparan Sulfate in Bacterial Pathogenesis
    Pyong Woo Park; Fiscal Year: 2010
    ..factor in a wide range of biological processes, including cell adhesion, migration and proliferation, blood coagulation, and microbial infections...
  41. Mechanisms of fibrin action in multiple sclerosis
    Katerina Akassoglou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fibrinogen, a critical component of blood coagulation, extravasates across a damaged blood-brain barrier (BBB) and accumulates as fibrin deposits at specific sites of injury...
  42. Endothelial cell phosphatidylserine, topography, and procoagulant activity
    Gary E Gilbert; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Blood coagulation prevents hemorrhage and also contributes to thrombotic diseases including myocardial infarction, stroke, and venous thromboembolism...
  43. TLR2 in Sepsis-Induced Coagulopathy, Endothelial Leak, and Pulmonary Dysfunction
    Judith Hellman; Fiscal Year: 2010
    ..b>Blood coagulation times will be measured, and levels of factors involved in coagulation and fibrinolysis will be quantified in ..
  44. Development and Pharmacology of Novel Lipidic rAHF
    SATHY VENKAT BALU-IYER; Fiscal Year: 2013
    ..FVIII is a multi-domain protein that plays a critical role in blood coagulation cascade. The deficiency and dysfunction of FVIII causes Hemophilia A, a bleeding disorder...
  45. ER-to-Golgi transport of coagulation factors V and VIII
    Bin Zhang; Fiscal Year: 2013
    ..project will study a transport receptor that when absent, cause a human genetic disorder with low levels of blood coagulation factors V and VIII...
  46. Air Pollution and Cardiac Risk: Mechanisms & Time-course
    Duanping Liao; Fiscal Year: 2010
    ..s (24-hour cumulative exposure) directly related to elevated markers of inflammation, blood coagulation, and fibrinolytic activity? (8) Are 24-hour cumulative concentrations of the ambient PM2...
  47. The role of polyphosphates in blood coagulation and inflammation
    SHARON HYONJU CHOI; Fiscal Year: 2013
    ..Results from the studies in these three aims will provide new insights into how polyP modulates the blood clotting system to drive thrombosis and inflammation. ..
  48. Characterization of Vitamin K Epoxide Reductase
    Darrel W Stafford; Fiscal Year: 2013
    ..essential post-translational modification for proteins important in several physiologic functions, including blood coagulation and bone metabolism...
  49. Proteinase Allostery and the Regulation of Blood Coagulation
    Sriram Krishnaswamy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thrombin, the terminal serine proteinase of the blood coagulation cascade, plays a pivotal role in thrombus formation as well as its regulation...
  50. Investigation of protein interactions in intrinsic blood coagulation pathway
    Divi Venkateswarlu; Fiscal Year: 2007
    ..funding period, we propose to develop structural assembly of multi-domain proteins associated with intrinsic blood coagulation pathway...
  51. PROGRAM IN BLOOD COAGULATION AND VASCULAR BIOLOGY
    Bruce Furie; Fiscal Year: 2013
    ..The goal of this program is to train MD and PhD postdoctoral fellows in biomedical research as it applies to Blood Coagulation and Vascular Biology...
  52. Chemoenzymatic Synthesis of Heparin and Heparan Sulfate Oligosaccharides
    Xuefei Huang; Fiscal Year: 2013
    ..HS) participate in a wide variety of physiological and pathological events, including viral infection, blood coagulation, cell differentiation and cancer metastasis...
  53. Triple Analysis of Blood Clotting using Driven and Diffusing Microbeads
    Richard Chasen Spero; Fiscal Year: 2013
    ..Assessing clot quality is essential for studying, diagnosing, and treating disease Conventional blood coagulation tests can be grouped into three areas: clotting time, mechanical stability, and permeability...
  54. Fibrin Clot Architecture Regulated by Factor XIII
    Muriel C Maurer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In blood coagulation, thrombin cleaves fibrinogen (AaBbg)2, sites for fibrin polymerization are revealed, and fibrin clot formation begins...
  55. ULTRAFAST OPTICAL PROCESSES LABORATORY
    Feng Gai; Fiscal Year: 2013
    ..and Azide probes (Brewer) (2) Protonated histidines (Londergan) (3) Amyloid fluorescence (Petersson)(4) Blood coagulation (Knshnaswamy) (5) Kinases models (Sarkar)(6)Amyloid kinetics (Dai) (7) Oxygen microscopy (Vinogradov), The ..
  56. METAL DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 2002
    ..The current frontier in understanding blood coagulation on a molecular basis is determining how the functional macromolecular complexes which facilitate blood ..
  57. 2010 Hemostasis Gordon Research Conference and/or Gordon Research Seminar
    Nigel Mackman; Fiscal Year: 2010
    ..is that the Hemostasis GRC is widely considered to be the premiere small meeting on the topics of blood coagulation, platelet biology, and anticoagulant pathways, enjoying both national and international reputation...
  58. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA MOHAN RAO LELLA; Fiscal Year: 2010
    ..present proposal is to understand the mechanisms controlling the initiation and regulation of TF-dependent blood coagulation. The majority of TF on cell surfaces exists in a cryptic (coagulant inactive) state...
  59. CELLULAR REGULATION OF BLOOD CLOTTING
    Marc Shuman; Fiscal Year: 1992
    This proposal is focused on two long-term goals: 1) characterization of regulation of synthesis of blood coagulation Factor XIII, and 2) characterization of platelet membrane proteins and pathogenesis of immune platelet disorders...
  60. ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUS
    Perumal Thiagarajan; Fiscal Year: 2003
    Prothrombin is the precursor of thrombin, the central enzyme in blood coagulation. Prothrombin binding autoantibodies from lupus patients are clinically associated with thrombosis, but the association is paradoxical, because conventional ..
  61. MOLECULAR INTERACTIONS OF BLOOD COAGULATION FACTOR XA
    Katherine High; Fiscal Year: 1999
    b>Blood coagulation Factor X occupies a central role in the clotting cascade. It can be activated by either Factor VIIa-tissue factor (extrinsic tenase) or by Factor IXa-VIIIa-phospholipid (intrinsic tenase)...
  62. 2012 Hemostasis Gordon Research Conference and Gordon Research Seminar
    Sriram Krishnaswamy; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: We request partial support for a Gordon Research Conference focused on normal blood coagulation as well as excessive bleeding and thrombosis prevalent in human disease...
  63. MOLECULAR INTERACTIONS OF BLOOD COAGULATION FACTOR X
    RICHARD PAINTER; Fiscal Year: 1991
    ..Identification of sites of interactions on factor X/Xa may lead to the production of therapeutic agents (peptides and/or monoclonal antibodies) which can impede coagulation and regulate hemostasis...
  64. Structure & Function of the Gamma-Glutamyl Carboxylase
    Darrel W Stafford; Fiscal Year: 2011
    ..This series of reactions is important for post- translational modification of proteins involved in blood coagulation, bone formation, and a number of other physiological processes...
  65. Structure/Function Study of the Anticoagulant Protein S
    Alan Rigby; Fiscal Year: 2005
    b>Blood coagulation involves the assembly of calcium- dependent macromolecular complexes on phospholipid membranes...
  66. Structural Mechanisms for the Inhibition of Thrombosis
    JAMES HUNTINGTON; Fiscal Year: 2009
    ..to understand the three natural mechanisms which control the activity of thrombin, the final protease of the blood coagulation cascade: 1) prevention of thrombin formation through inhibition of upstream coagulation factor Xa;2) direct ..
  67. Structural studies of blood coagulation proteins
    Barry Stoddard; Fiscal Year: 2006
    ..Factor VIII (fVIII) is a serum protein that acts as a critical cofactor and regulator of the intrinsic blood coagulation pathway...
  68. Novel Reagents to Bypass Limitations of Existing Coagulation Assays
    Stephen Burgess; Fiscal Year: 2009
    ..an optimal short carbon chain lipid species to be used as a surrogate for membranes in a novel and improved blood coagulation factor assays that will improve rapid diagnosis of coagulation disorders...
  69. MOLECULAR MECHANISMS OF BLOOD COAGULATION ACTIVATION
    JOSEPH SHORE; Fiscal Year: 1991
    ..objective of this project is a complete understanding, at the molecular level, of contact activation of blood coagulation and the factors affecting it...