hemostasis

Summary

Summary: The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.

Top Publications

  1. ncbi Role and importance of phenoloxidase in insect hemostasis
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA
    J Innate Immun 3:28-33. 2011
  2. pmc Microparticles in hemostasis and thrombosis
    A Phillip Owens
    Division of Hematology Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, North Carolina, USA
    Circ Res 108:1284-97. 2011
  3. ncbi Protease-activated receptors in hemostasis, thrombosis and vascular biology
    S R Coughlin
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    J Thromb Haemost 3:1800-14. 2005
  4. ncbi Platelets at work in primary hemostasis
    Katleen Broos
    Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kortrijk, Belgium
    Blood Rev 25:155-67. 2011
  5. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
  6. ncbi New fundamentals in hemostasis
    Henri H Versteeg
    Einthoven Laboratroy for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Physiol Rev 93:327-58. 2013
  7. ncbi Snake venoms and hemostasis
    Q Lu
    Theodor Kocher Institute, University of Berne, Berne, Switzerland
    J Thromb Haemost 3:1791-9. 2005
  8. ncbi Platelets: bridging hemostasis, inflammation, and immunity
    C N Jenne
    Calvin Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada
    Int J Lab Hematol 35:254-61. 2013
  9. ncbi Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
    Irina Pleines
    Chair of Vascular Medicine, University Hospital Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Josef Schneider Strasse 2, Wurzburg, Germany
    Blood 119:1054-63. 2012
  10. pmc Dynamic reciprocity in the wound microenvironment
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
    Wound Repair Regen 19:134-48. 2011

Detail Information

Publications280 found, 100 shown here

  1. ncbi Role and importance of phenoloxidase in insect hemostasis
    Ioannis Eleftherianos
    Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA
    J Innate Immun 3:28-33. 2011
    ..Here we review our current knowledge of the association between PO and coagulation and discuss the implications of the previous findings on insect innate immunity and hemostasis.
  2. pmc Microparticles in hemostasis and thrombosis
    A Phillip Owens
    Division of Hematology Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, North Carolina, USA
    Circ Res 108:1284-97. 2011
    ..This review will summarize our current knowledge of the role of procoagulant MPs in hemostasis and thrombosis.
  3. ncbi Protease-activated receptors in hemostasis, thrombosis and vascular biology
    S R Coughlin
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    J Thromb Haemost 3:1800-14. 2005
    ..An important role for PARs in hemostasis and thrombosis is established in animal models, and studies in knockout mice and nonhuman primates raise the ..
  4. ncbi Platelets at work in primary hemostasis
    Katleen Broos
    Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kortrijk, Belgium
    Blood Rev 25:155-67. 2011
    ..life vascular damage is a rather common event and that hence the role of platelets in maintaining a normal hemostasis is a continuously ongoing physiological process...
  5. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target.
  6. ncbi New fundamentals in hemostasis
    Henri H Versteeg
    Einthoven Laboratroy for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Physiol Rev 93:327-58. 2013
    b>Hemostasis encompasses the tightly regulated processes of blood clotting, platelet activation, and vascular repair...
  7. ncbi Snake venoms and hemostasis
    Q Lu
    Theodor Kocher Institute, University of Berne, Berne, Switzerland
    J Thromb Haemost 3:1791-9. 2005
    Snake venoms are complex mixtures of biologically active proteins and peptides. Many of them affect hemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium...
  8. ncbi Platelets: bridging hemostasis, inflammation, and immunity
    C N Jenne
    Calvin Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada
    Int J Lab Hematol 35:254-61. 2013
    Although the function of platelets in the maintenance of hemostasis has been studied in great detail, more recent evidence has highlighted a central role for platelets in the host inflammatory and immune responses...
  9. ncbi Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
    Irina Pleines
    Chair of Vascular Medicine, University Hospital Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Josef Schneider Strasse 2, Wurzburg, Germany
    Blood 119:1054-63. 2012
    Vascular injury initiates rapid platelet activation that is critical for hemostasis, but it also may cause thrombotic diseases, such as myocardial infarction or ischemic stroke...
  10. pmc Dynamic reciprocity in the wound microenvironment
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
    Wound Repair Regen 19:134-48. 2011
    ..The implications of applying the principles of DR to optimize wound care practice and future development of innovative wound healing therapeutics are also briefly considered...
  11. pmc Evolution of primary hemostasis in early vertebrates
    Seongcheol Kim
    Department of Biological Sciences, University of North Texas, Denton, Texas, USA
    PLoS ONE 4:e8403. 2009
    b>Hemostasis is a defense mechanism which protects the organism in the event of injury to stop bleeding. Recently, we established that all the known major mammalian hemostatic factors are conserved in early vertebrates...
  12. pmc Serpins in thrombosis, hemostasis and fibrinolysis
    J C Rau
    Department of Pathology and Laboratory Medicine, Carolina Cardiovascular Biology Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7035, USA
    J Thromb Haemost 5:102-15. 2007
    b>Hemostasis and fibrinolysis, the biological processes that maintain proper blood flow, are the consequence of a complex series of cascading enzymatic reactions...
  13. ncbi The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients
    Karen M Hook
    Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 5:85-92. 2012
    ..Currently, activated protein C is the only approved therapy in the United States for sepsis complicated by DIC. Further research is needed in this area to improve clinical outcomes for patients with sepsis...
  14. ncbi Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis
    Nigel Mackman
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Code SP30 3040, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 27:1687-93. 2007
    b>Hemostasis requires both platelets and the coagulation system. At sites of vessel injury, bleeding is minimized by the formation of a hemostatic plug consisting of platelets and fibrin...
  15. ncbi Role of cardiac myocyte tissue factor in heart hemostasis
    R Pawlinski
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    J Thromb Haemost 5:1693-700. 2007
    ..Hemosiderosis and fibrosis are observed in the hearts of all low TF mice as early as 3 months of age. In contrast, TF(+/-) mice expressing approximately 50% of wild-type levels of TF had no detectable hemostatic defects...
  16. pmc von Willebrand factor: an emerging target in stroke therapy
    Simon F De Meyer
    Immune Disease Institute, Children s Hospital Boston, Boston, MA, USA
    Stroke 43:599-606. 2012
    ..Preclinical and clinical evidence illustrates an important role of VWF in ischemic stroke, suggesting that VWF could become a promising target in stroke therapy...
  17. pmc Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred
    Nicolas Prevost
    Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:9219-24. 2002
    ....
  18. pmc Growth arrest-specific gene 6 (gas6) and vascular hemostasis
    Sandrine Laurance
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Adv Nutr 3:196-203. 2012
    ..However, the mechanism in thrombus occurrence remains to be further explored. In the present review, we will focus on the role of gas6 in innate immunity, atherosclerosis, thrombosis, and cancer-related events...
  19. ncbi Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls
    Peter W Collins
    Department of Haematology, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK
    Br J Haematol 135:220-7. 2006
    ..005). In conclusion, global tests of haemostasis suggest that in this patient group, activation of haemostasis is delayed but once initiated thrombin generation and clot formation are normal or enhanced...
  20. ncbi Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences
    Ton Lisman
    Section Hepatobiliairy Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Blood 116:878-85. 2010
    Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to their disease...
  21. ncbi Brain endothelial hemostasis regulation by pericytes
    Jeong Ai Kim
    Department of Neurology, University of California, Irvine, California, USA
    J Cereb Blood Flow Metab 26:209-17. 2006
    ..These in vitro findings suggest that pericytes negatively regulate brain endothelial cell fibrinolysis, while pericyte expression of PN-1 may provide endogenous anticoagulant activity...
  22. ncbi Hemostasis and platelet dysfunction in asphyxiated neonates
    Mary E Bauman
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Pediatr 158:e35-9. 2011
    b>Hemostasis is the balance between bleeding and clotting and includes coagulation and fibrinolysis with platelet interactions...
  23. ncbi Hemoconcentration and hemostasis during acute stress: interacting and independent effects
    Anthony W Austin
    Department of Psychology, Ohio University, Athens, OH, USA
    Ann Behav Med 42:153-73. 2011
    ..It is unclear whether these effects are independent or have influence on each other...
  24. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh)...
  25. ncbi The genetics of haemostasis: a twin study
    M de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, UK
    Lancet 357:101-5. 2001
    ..Our results stress the importance of research into the genetic regulation of proteins involved in haemostasis and atherothrombotic disorders, including myocardial infarction and stroke...
  26. ncbi Genetic pathways linking hemostasis and cancer
    Delphine Garnier
    Montreal Children s Hospital, McGill University, QC, Canada
    Thromb Res 129:S22-9. 2012
    ..Amongst the most consequential, in this regard, is the influence on angiogenesis, inflammation and hemostasis. Indeed, mutant oncogenes (EGFR, HER2, RAS, MET, PML-RARα) are known to alter the expression of angiogenic and ..
  27. ncbi Biological influence of physical exercise on hemostasis
    Giuseppe Lippi
    Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Italy
    Semin Thromb Hemost 35:269-76. 2009
    Some of the benefits of physical activity may result from effects on hemostasis. However, the increased burden of cardiovascular complications and sudden death occurring during and immediately after exercise prompts investigation to ..
  28. ncbi Effects of leaf extracts from Croton zambesicus Müell. Arg. on hemostasis
    Séverine Robert
    Department of Pharmacy, Drug Design and Discovery Center, University of Namur, FUNDP, rue de Bruxelles, 61, 5000 Namur, Belgium
    J Ethnopharmacol 128:641-8. 2010
    ..The leaf decoction of Croton zambesicus Müell. Arg. (Euphorbiaceae; syn. Croton amabilis Müell. Arg., Croton gratissimus Burch) is traditionally used in Benin to treat hypertension...
  29. ncbi Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure
    J Shi
    Department of Medicine, VA Boston Healthcare System, Brigham, Women s Hospital and Harvard Medical School, Boston, MA 02132, USA
    J Thromb Haemost 6:1167-74. 2008
    Platelet membrane phosphatidylserine (PS) is considered to be essential for hemostasis and thrombosis, but the in vivo topography of platelet PS has not been characterized...
  30. ncbi Laser-induced thrombosis in zebrafish
    Pudur Jagadeeswaran
    Department of Biological Sciences, University of North Texas, Denton, Texas, USA
    Methods Cell Biol 101:197-203. 2011
    ..the event of injury to the vasculature in vertebrate organisms bleeding is stopped by a defense mechanism called hemostasis. Even though biochemical studies characterized a number of factors, classical genetic methods have not been ..
  31. ncbi Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans
    Martin Ungerer
    Martinsried, Germany
    Circulation 123:1891-9. 2011
    ..A dose-escalating clinical phase I study was performed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of Revacept in humans...
  32. ncbi Visceral fat as a determinant of fibrinolysis and hemostasis
    Ilse Mertens
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
    Semin Vasc Med 5:48-55. 2005
    ..visceral fat has generally been accepted as an important cardiovascular risk factor, and disturbances in hemostasis and fibrinolysis have been suggested to play a role...
  33. ncbi Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review
    Christiane S Hartog
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Intensive Care Med 37:1725-37. 2011
    Hydroxyethyl starch solutions (HES) are plasma volume expanders which affect hemostasis. Newer HES 130/0.4 is said to be safer. Reevaluation of published evidence is necessary after the recent retraction of studies.
  34. ncbi Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense
    Adrian R L Gear
    Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Microcirculation 10:335-50. 2003
    Blood platelets play critical roles in hemostasis, providing rapid essential protection against bleeding and catalyzing the important slower formation of stable blood clots via the coagulation cascade...
  35. pmc Thrombin generation, fibrin clot formation and hemostasis
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, 815 Brinkhous Bullitt Building, CB 7525, Chapel Hill, NC 27599 7525, USA
    Transfus Apher Sci 38:15-23. 2008
    ..Further studies of fibrin formation during in situ thrombin generation are needed to understand fibrin clot formation in vivo...
  36. pmc Decidual hemostasis, inflammation, and angiogenesis in pre-eclampsia
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Semin Thromb Hemost 37:158-64. 2011
    ....
  37. ncbi Developmental haemostasis. Impact for clinical haemostasis laboratories
    Paul Monagle
    Department of Haematology, Royal Children s Hospital Melbourne, and University of Melbourne, Grattan Street, Parkville, Victoria 3051, Australia
    Thromb Haemost 95:362-72. 2006
    ..Finally we present age related reference ranges for D-dimers, TFPI, and endogenous thrombin potential, previously not described...
  38. ncbi Salvianolic acid B modulates hemostasis properties of human umbilical vein endothelial cells
    Chung Sheng Shi
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Thromb Res 119:769-75. 2007
    ..These data suggest that Sal B is clinically effective because of its ability to change the gene expression profile of endothelial cells thereby preventing vascular events...
  39. ncbi Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Intern Emerg Med 5:7-12. 2010
    ..liver disease is characterized by a global hemostatic defect including platelet-vessel wall interaction (primary hemostasis), coagulation and fibrinolysis that may cause abnormalities of the relevant laboratory tests...
  40. ncbi Platelets: physiology and biochemistry
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Munster, Munster, Germany
    Semin Thromb Hemost 31:381-92. 2005
    Platelets are specialized blood cells that play central roles in physiologic and pathologic processes of hemostasis, inflammation, tumor metastasis, wound healing, and host defense...
  41. ncbi The role of collagen in thrombosis and hemostasis
    R W Farndale
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    J Thromb Haemost 2:561-73. 2004
  42. ncbi Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
    The aim of our present study was to compare the association of a wide range of 17 biomarkers of inflammation, hemostasis, and blood rheology with incident heart disease and stroke after accounting for an indicator of subclinical ..
  43. pmc Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates
    Ashley W Seifert
    Department of Biology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e32875. 2012
    ..In the context of mammalian wound repair, our findings reveal a substantial reduction in hemostasis, reduced neutrophil infiltration and a relatively long delay in production of new extracellular matrix (ECM) ..
  44. ncbi Arterial thrombosis--insidious, unpredictable and deadly
    Shaun P Jackson
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Australia
    Nat Med 17:1423-36. 2011
    ..However, major advances in this field require the identification of specific risk factors for arterial thrombosis in affected individuals and a rethink of the 'one size fits all' approach to antithrombotic therapy...
  45. ncbi Acute coagulopathy of trauma: balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Med Hypotheses 75:564-7. 2010
    ..activates the sympathoadrenal system resulting in high circulating levels of catecholamines that influence hemostasis dose-dependently through immediate effects on the two major compartments of hemostasis, i.e...
  46. pmc The plasma hemostatic proteome: thrombin generation in healthy individuals
    K Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    J Thromb Haemost 3:1472-81. 2005
    ..The range of plasma concentrations of hemostatic analytes in the population is wide. In this study these components of blood coagulation phenotype are integrated in an attempt to predict clinical risk...
  47. ncbi Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis
    T Sakai
    Department of Experimental Pathology, Lund University, Lund, Sweden
    Nat Med 7:324-30. 2001
    ..Here we show that pFn-deficient mice show increased neuronal apoptosis and larger infarction areas following transient focal cerebral ischemia. However, pFn is dispensable for skin-wound healing and hemostasis.
  48. ncbi Role of tissue factor in hemostasis, thrombosis, and vascular development
    Nigel Mackman
    The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, Calif 92037, USA
    Arterioscler Thromb Vasc Biol 24:1015-22. 2004
    ..These results indicate that TF is essential for life, most likely because of its central role in hemostasis. In addition, aberrant TF expression within the vasculature initiates life-threatening thrombosis in various ..
  49. ncbi Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease
    F Gerald R Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Vasc Surg 43:474-80. 2006
    ..The aim of this study was to determine if these factors accounted for the link between aneurysms and pulmonary disease...
  50. ncbi The physiological function of von Willebrand's factor depends on its tubular storage in endothelial Weibel-Palade bodies
    Gregoire Michaux
    Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 10:223-32. 2006
    ..Thus, a 100-fold compaction of VWF into tubules determines the unique shape of Weibel-Palade bodies and is critical to this protein's hemostatic function...
  51. ncbi Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study
    Ann Smith
    Department of Epidemiology and Public Health, Queen s University, Belfast BT12 6BJ, UK
    Circulation 112:3080-7. 2005
    ..This study examines 11 hemostatic markers that reflect different aspects of the coagulation process to determine which have prognostic value after accounting for conventional risk factors...
  52. ncbi Tissue factor-positive microparticles: cellular origin and association with coagulation activation in patients with colorectal cancer
    Gregor Hron
    Dept of Internal Medicine I, Medical University Vienna, Austria
    Thromb Haemost 97:119-23. 2007
    ..017). TF (+) MPs correlated with D-dimer ( ? = 0.48, p = 0.002). High levels of TF (+) MPs in cancer patients and their correlation with D-dimer suggest that TF (+) MPs might be involved in hemostasis activation in cancer patients.
  53. ncbi Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial
    Ming Chih Hou
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, No 201 Sec 2 Shih Pai Road, Taipei, Taiwan 11217, ROC
    Hepatology 39:746-53. 2004
    Bacterial infection may adversely affect the hemostasis of patients with gastroesophageal variceal bleeding (GEVB). Antibiotic prophylaxis can prevent bacterial infection in such patients, but its role in preventing rebleeding is unclear...
  54. ncbi The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis
    Haikun Wang
    Department of Cell Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    Haematologica 92:643-50. 2007
    The molecular mechanisms regulating megakaryocytopoiesis and hemostasis remain largely unknown...
  55. ncbi Modifier genes for disorders of thrombosis and hemostasis
    R J Westrick
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    J Thromb Haemost 7:132-5. 2009
    ....
  56. pmc Novel hemostatic factor levels and risk of ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study
    M Fareed K Suri
    Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Cerebrovasc Dis 29:497-502. 2010
    ..The role of hemostatic factor levels in cerebral infarction remains uncertain. We studied the association of levels of several under-studied hemostatic factors with ischemic stroke in a population-based cohort...
  57. ncbi A functional role for hemostasis in early cancer development
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Turino, Italy
    Cancer Res 65:8579-82. 2005
    ..These findings reveal a long-sought mechanistic link between coagulation and cancer, highlighting a clinically important perspective on malignant invasion and metastasis...
  58. ncbi Mitogen-activated protein kinases in hemostasis and thrombosis
    F Adam
    Centre de Recherche Cardiovasculaire INSERM Lariboisiére U689, Hopital Lariboisiere, Paris, France
    J Thromb Haemost 6:2007-16. 2008
    ..This review summarizes and discusses the physiological functions of these kinases in hemostasis and thrombosis as revealed by various technical approaches.
  59. ncbi Hemostatic factors, innate immunity and malignancy
    Jay L Degen
    Cancer and Blood Diseases Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Thromb Res 129:S1-5. 2012
    ....
  60. ncbi Fabrication of self-assembling D-form peptide nanofiber scaffold d-EAK16 for rapid hemostasis
    Zhongli Luo
    West China Hospital, Laboratory for Nanobiomedical Technology, Sichuan University, Chengdu, Sichuan 610065, China
    Biomaterials 32:2013-20. 2011
    ..individual molecular building blocks and their structures, assembly properties and dynamic behaviors for rapid hemostasis, we used circular dichroism, atomic force microscopy and scanning electron microscopy to study in detail the ..
  61. pmc Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis
    Sassan HajMohammadi
    Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    J Clin Invest 111:989-99. 2003
    ..Surprisingly, this bulk of HS(act) is not essential for normal hemostasis in mice...
  62. pmc Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis
    S Kanaji
    Blood Research Institute, BloodCenter of Wisconsin, Department of Pediatrics, Medical College of Wisconsin, Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    J Thromb Haemost 10:1646-52. 2012
    von Willebrand factor (VWF) is a glycoprotein that plays an important role in primary hemostasis. VWF is synthesized and stored in endothelial cells (ECs) and megakaryocytes/platelets...
  63. ncbi Vitamin D, thrombosis, and hemostasis: more than skin deep
    Giovanni Targher
    Section of Endocrinology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Semin Thromb Hemost 38:114-24. 2012
    ..Large placebo-controlled randomized clinical trials are urgently needed to determine whether vitamin D supplementation could have any potential benefit in reducing future CVD events and mortality risk...
  64. pmc Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Anesth Analg 114:275-85. 2012
    ..In this review, we focus on contributions of blood composition, vascular cells, and blood flow to hemostasis and thrombosis, and suggest that cross-talk among the 3 components of Virchow's triad is necessary for ..
  65. ncbi Fibrinogen and hemostasis: a primary hemostatic target for the management of acquired bleeding
    Jerrold H Levy
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA
    Anesth Analg 114:261-74. 2012
    Fibrinogen plays several key roles in the maintenance of hemostasis. Its cleavage by thrombin and subsequent polymerization to form fibrin strands provides the structural network required for effective clot formation...
  66. pmc A pH-regulated dimeric bouquet in the structure of von Willebrand factor
    Yan Feng Zhou
    Department of Pathology, Harvard Medical School, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital, Boston, MA 02115, USA
    EMBO J 30:4098-111. 2011
    ..in VWF provide an overall view of VWF structure important for understanding both the biogenesis of ultralong concatamers at acidic pH and flow-regulated changes in concatamer conformation in plasma at alkaline pH that trigger hemostasis.
  67. ncbi Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography
    R Todd Stravitz
    Section of Hepatology and Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    J Hepatol 56:129-36. 2012
    ..We hypothesized that patients with ALI/ALF have normal hemostasis despite elevated INR.
  68. ncbi Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
    Adriana Vieira-de-Abreu
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Semin Immunopathol 34:5-30. 2012
    Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive ..
  69. pmc Platelets: linking hemostasis and cancer
    Shashank Jain
    Department of Physiology and Biophysics, University of Arkansas for Medical Science, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 30:2362-7. 2010
    ..the main cellular component in blood responsible for maintaining the integrity of the cardiovascular system via hemostasis. Platelet dysfunction contributes to a wide range of obvious pathological conditions, such as bleeding or ..
  70. ncbi The pleiotropic role of the fibrinogen gamma' chain in hemostasis
    Shirley Uitte de Willige
    Division of Cardiovascular and Diabetes Research, Section on Mechanisms of Thrombosis, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, United Kingdom
    Blood 114:3994-4001. 2009
    ..This review summarizes the key biologic aspects of this interesting variant of fibrinogen and discusses inconsistencies in current reports...
  71. ncbi Hydroxyethyl starch as a priming solution for cardiopulmonary bypass impairs hemostasis after cardiac surgery
    Anne H Kuitunen
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Meilahti Hospital, Helsinki, Finland
    Anesth Analg 98:291-7, table of contents. 2004
    ..of hydroxyethyl starch (HES) as a priming solution for the cardiopulmonary bypass (CPB) circuit on postoperative hemostasis in 45 patients undergoing elective coronary artery bypass grafting...
  72. pmc Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype
    Joshua I Siner
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 121:4396-403. 2013
    ..Injection of FVIII-RH protein in hemophilia A (HA) mice resulted in more efficacious hemostasis following vascular injury in both the macro- and microcirculation...
  73. ncbi Nutrition and hemostasis: a focus on urbanization in South Africa
    Marlien Pieters
    Faculty of Health Sciences, School of Physiology and Nutrition, North West University, Potchefstroom, South Africa
    Mol Nutr Food Res 52:164-72. 2008
    ..It is further suggested that timely nutritional interventions and research of effects thereof on the hemostatic system are urgently needed...
  74. ncbi A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells
    Aya Shibamiya
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    Blood 113:714-22. 2009
    Various virus infections cause dysfunctional hemostasis and in some instances lead to the development of viral hemorrhagic fever syndrome...
  75. ncbi Signaling and regulation of the platelet glycoprotein Ib-IX-V complex
    Xiaoping Du
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Curr Opin Hematol 14:262-9. 2007
    ..Significant progress has been made recently on the signaling pathways and regulatory mechanisms involving glycoprotein Ib-IX-V function...
  76. ncbi Altered hemostasis in pulmonary hypertension
    K L Hassell
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Blood Coagul Fibrinolysis 9:107-17. 1998
    ..However, the direct link between altered coagulation and the development or persistence of pulmonary hypertension awaits confirmation...
  77. ncbi Influence of a long-term, high-dose volume therapy with 6% hydroxyethyl starch 130/0.4 or crystalloid solution on hemodynamics, rheology and hemostasis in patients with acute ischemic stroke. Results of a randomized, placebo-controlled, double-blind study
    Ralph Woessner
    Department of Neurology, Westpfalz Klinikum, University City of Kaiserslautern, Kaiserslautern, Germany
    Pathophysiol Haemost Thromb 33:121-6. 2003
    ..4 versus crystalloid solution, with particular regard to systemic and cerebral hemodynamics, rheology and safety...
  78. pmc Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, United States
    Mol Genet Metab 101:163-71. 2010
    ....
  79. ncbi Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry
    C Huissoud
    Department of Obstetrics and Gynecology, Croix Rousse University Hospital, Hospices Civils de Lyon, Lyon, France
    BJOG 116:1097-102. 2009
    ..To establish whether reagent-supported thrombelastometry with the rotation thrombelastometry system (ROTEM) point-of-care device correlated with fibrinogen level in postpartum haemorrhages...
  80. pmc Empirical and theoretical phenotypic discrimination
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, Colchester, VT 05446, USA
    J Thromb Haemost 7:181-6. 2009
    ....
  81. ncbi Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Am J Physiol Heart Circ Physiol 291:H985-1002. 2006
    Endothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability...
  82. ncbi Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding
    Ina Hagedorn
    University Clinic, University of Wurzburg, 97080 Wurzburg, Germany
    Circulation 121:1510-7. 2010
    ..XII-induced intrinsic coagulation pathway is essential for pathological thrombus formation but dispensable for hemostasis. Consequently, these findings led to the hypothesis that factor XII could be a promising pharmacological target ..
  83. ncbi Use of recombinant activated factor VII in severe post-partum haemorrhage: data from the Italian Registry: a multicentric observational retrospective study
    Giovanni Barillari
    Center for Hemorrhagic and Thrombotic Diseases, Department of Transfusion Medicine, General University Hospital of Udine, Italy
    Thromb Res 124:e41-7. 2009
    ..To report the Italian real experience in clinical practice about recombinant factor VII activated (rFVIIa) in Post-Partum Haemorrhage (PPH) treatment...
  84. ncbi Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis
    D English
    Experimental Cell Research Program, Methodist Research Institute, Indianapolis, Indiana 46202, USA
    FASEB J 14:2255-65. 2000
    ..Our results show that blood coagulation initiates endothelial cell angiogenic responses through the release of S1P, a potent endothelial cell chemoattractant that exerts its effects by activating a receptor-dependent process...
  85. pmc Infection of human coronary artery endothelial cells by group B streptococcus contributes to dysregulation of apoptosis, hemostasis, and innate immune responses
    Claudia Beyrich
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Mediators Inflamm 2011:971502. 2011
    ..Regulated genes are involved in apoptosis, hemostasis, oxidative stress response, infection, and inflammation...
  86. pmc Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis
    Qiansheng Ren
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Blood 116:869-77. 2010
    ..These data highlight the importance of Munc13-4 in platelets and indicate that it is a limiting factor required for platelet secretion and hemostasis.
  87. ncbi Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation
    Alexander Y Mitrophanov
    DoD Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, US Army Medical Research and Materiel Command, ATTN MCMR TT, 504 Scott Street, Ft Detrick, MD 21702, USA
    Thromb Res 128:381-90. 2011
    ..For recombinant activated factor VII (rFVIIa)--a promising hemostasis-inducing biologic--experimental studies addressing its effects on thrombin generation yielded disparate results...
  88. ncbi Ristocetin-induced self-aggregation of von Willebrand factor
    Massimiliano Papi
    Istituto di Fisica, Universita Cattolica S Cuore, Rome, Italy
    Eur Biophys J 39:1597-603. 2010
    Von Willebrand factor (VWF) is a large multimeric adhesive glycoprotein, with complex roles in thrombosis and hemostasis, present in circulating blood and in secretory granules of endothelial cells and platelets...
  89. ncbi Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents
    Ole Halfdan Larsen
    Centre for Haemophilia and Thrombosis, Aarhus University Hospital, Skejby, Denmark
    Anesthesiology 115:294-302. 2011
    ....
  90. pmc Defining the boundaries of normal thrombin generation: investigations into hemostasis
    Christopher M Danforth
    Department of Mathematics and Statistics, Center for Complex Systems, Vermont Advanced Computing Center, University of Vermont, Burlington, Vermont, United States of America
    PLoS ONE 7:e30385. 2012
    ....
  91. ncbi Sex differences and the effects of sex hormones on hemostasis and vascular reactivity
    D W Schwertz
    College of Nursing, University of Illinois, Chicago, 60612, USA
    Heart Lung 30:401-26; quiz 427-8. 2001
    ..This review focuses on sex (gender) differences in hemostasis and vascular reactivity and on the influence that sex hormones have on these physiologic systems...
  92. ncbi Hemostasis and hemostatic agents in minimally invasive surgery
    Roger A de la Torre
    Department of General Surgery, University of Missouri Columbia, Columbia, MO 65211, USA
    Surgery 142:S39-45. 2007
    ..Traditional electrical and mechanical means are still the mainstay, but new technologies for hemostasis continue to emerge...
  93. ncbi Fibrinogen concentrate--a potential universal hemostatic agent
    Christian Fenger-Eriksen
    Aarhus University Hospital, Department of Anaesthesiology, Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    Expert Opin Biol Ther 9:1325-33. 2009
    ..Accumulating new data suggest that fibrinogen plays a critical role in achieving and maintaining hemostasis, particularly in patients suffering from acquired fibrinogen deficiency during massive bleeding, where benefit ..
  94. ncbi GPVI and CLEC-2 in hemostasis and vascular integrity
    S P Watson
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    J Thromb Haemost 8:1456-67. 2010
    ..this article, we compare the mechanism of platelet activation by GPVI and CLEC-2 and consider their functional roles in hemostasis and other vascular processes, including maintenance of vascular integrity, angiogenesis and lymphogenesis.
  95. pmc The role of tissue factor and factor VIIa in hemostasis
    Nigel Mackman
    Department of Medicine, Division of Hematology Oncology, University of North Carolina at Chapel Hill, NC 27599 7035, USA
    Anesth Analg 108:1447-52. 2009
    ..However, the mechanism by which recombinant FVIIa restores hemostasis has not been clearly defined...
  96. ncbi Hemostasis in Danio rerio: is the zebrafish a useful model for platelet research?
    M R Lang
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat, Tubingen, Germany
    J Thromb Haemost 8:1159-69. 2010
    New scientific models have been established in the past few years to identify novel factors of hemostasis and thrombosis and to analyze their function in greater detail...
  97. ncbi Decidual cell-expressed tissue factor in human pregnancy and its involvement in hemostasis and preeclampsia-related angiogenesis
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, P O Box 208063, New Haven, CT, 06510, USA
    Ann N Y Acad Sci 1127:67-72. 2008
    ....
  98. ncbi Septins, a novel group of GTP-binding proteins: relevance in hemostasis, neuropathology and oncogenesis
    S Roeseler
    University Hospital Freiburg, Department of Paediatrics and Adolescent Medicine, Freiburg i Br, Germany
    Klin Padiatr 221:150-5. 2009
    ..The different septins and their various isoforms seem to determine the function of the septin complex...
  99. ncbi Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene
    J E Freedman
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA
    Circ Res 84:1416-21. 1999
    ..These data suggest that the lack of platelet-derived NO alters in vivo hemostatic response by increasing platelet recruitment. Thus, these data support a role for platelet-derived NO production in the regulation of hemostasis.
  100. pmc Factor XII: what does it contribute to our understanding of the physiology and pathophysiology of hemostasis & thrombosis
    Evi Stavrou
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 7284, USA
    Thromb Res 125:210-5. 2010
    ..For over forty years, investigators in hemostasis have not considered FXII important because its deficiency is not associated with bleeding...
  101. ncbi Tests of global haemostasis and their applications in bleeding disorders
    S C Nair
    Christian Medical College, Vellore, India
    Haemophilia 16:85-92. 2010
    ..Furthermore, these tests need to be standardized with regard to their reagents, methodology and interpretation, and finally, much more data need to be collected regarding clinical correlations with the parameters measured...

Research Grants69

  1. Gene Therapy for hemophilia using muscle-expressed FVIIa
    Katherine A High; Fiscal Year: 2011
    ..control of bleeds by infusion of high-dose recombinant activated Factor VII (rFVIIa) results in effective hemostasis. However, this treatment carries a substantial cost due to the short half-life of the protein and the need for ..
  2. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..outcomes in terms of oncologic control, but is under-used due to major technical challenges of parenchymal hemostasis, pelvi-caliceal reconstruction, parenchymal renorrhaphy, bleeding and prolonged warm ischemia...
  3. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..by plasmin and CPB, thus establishing a new substrate for CPB and providing a novel molecular link between hemostasis/thrombosis and tissue inflammation and immunity. Aim 1...
  4. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..creatinine, cystatin C, ADMA, uric acid, 25(OH)vitamin D, parathyroid hormone);and (4) inflammation and hemostasis (hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum amyloid A, MMP-9, E-selectin, P-selectin, CD40 ligand, ..
  5. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..processes, including atherosclerosis, autoimmunity, allograft rejection, the diabetes-metabolic syndrome, hemostasis and thrombosis, and wound healing...
  6. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..well established roles in physiologic and pathologic processes such as renal perfusion, gastric cytoprotection, hemostasis, cancer, host defense, inflammation, and asthma...
  7. Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell
    Enrico M Novelli; Fiscal Year: 2013
    ..in the field of benign hematology with a specific focus on translational research in sickle cell disease and hemostasis. Dr...
  8. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2012
    ..2) Whole blood clotting studies using thromboelastography and hemostasis analysis system reveal that our novel anticoagulants inhibit clotting with potency only 18-30-fold weaker than ..
  9. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Blood platelets are required for hemostasis and abnormal platelet activation leads to thrombosis...
  10. Examination of the Final Stages of Platelet Production
    JONATHAN NOAH THON; Fiscal Year: 2013
    ..Research. Blood PLTs play an essential role in hemostasis and the pathophysiology of thrombosis...
  11. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ..racial disparities, maternal immunization, and maternal medical conditions - particularly thrombosis and hemostasis. Technical expertise includes study design, recruitment and retention, molecular biology, data safety monitoring,..
  12. Thiol Isomerases During Thrombus Formation
    Barbara C Furie; Fiscal Year: 2013
    ..released from platelets and endothelial cells, and their contribution to the modulation of function of proteins involved in thrombosis and hemostasis, including but not limited to GPIb, GPIIbIIIa and tissue factor.
  13. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    ..The generation, extent, and location of the fibrin clot are critical when hemostasis is compromised...
  14. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2012
    How platelets support homeostasis in the vascular system is a paradigm-central question in hemostasis and thrombosis...
  15. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..anti-phospholipid antibodies in patients suspected of APS including specific biomarker signatures for obstetric, hemostasis, and other autoimmune conditions...
  16. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    ..events are not fully understood, human and animal data increasingly suggest that PM-induced alterations in hemostasis resulting from lung inflammation and activation of the sympathetic nervous system play causal roles...
  17. Platelet-Derived FVIII Gene Therapy of Hemophilia A
    Qizhen Shi; Fiscal Year: 2013
    ..syngeneic transplantation of hematopoietic stem cells (HSC) from 2bF8 transgenic mice can efficiently restore hemostasis to hemophilic mice with inhibitors...
  18. Translational studies of the Platelet Specific Receptor Trem Like Transcript (TLT
    A Valance Washington; Fiscal Year: 2013
    ..The mechanisms that control the liaison between inflammation and hemostasis are poorly defined, and thus this liaison remains a gap in our knowledge...
  19. Screening for allosteric modulators of the protease activated receptor 4
    Heidi E Hamm; Fiscal Year: 2013
    ..Because of the delay in activation we hypothesize that PAR4 antagonism might not affect hemostasis as potently and thus may be a better therapeutic target than PAR1 in thrombosis and cerebrovascular injury...
  20. New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin Signali
    Guy A Zimmerman; Fiscal Year: 2010
    ..is uniquely well-suited to examine clinically-applicable and basic questions relevant to the pathobiology of hemostasis and inflammation, builds on new discoveries that we have recently made, and poses focused aims that can be ..
  21. INTEGRIN SIGNALING IN HEMOSTASIS AND BLOOD DISEASES
    Sanford J Shattil; Fiscal Year: 2012
    ..The synergy achieved by this Program will further our understanding of integrin signaling, with implications for disorders of cell adhesion affecting hemostasis and vascular repair.
  22. Smooth Muscle Cell Tissue Factor and Cardiovascular Disease
    Mark B Taubman; Fiscal Year: 2013
    ..provided by applicant): Tissue Factor (TF), the initiator of the coagulation cascade, plays a critical role in hemostasis and thrombosis...
  23. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
    ..inflammatory cells and epithelial tissues that cleave protease-activated receptors (PARs) to control hemostasis, inflammation, pain and repair...
  24. RESEARCH TRAINING IN HEMATOLOGY
    JOHN PATRICK SHEEHAN; Fiscal Year: 2012
    ..are a stable and interactive group that clusters in three major interest groups: basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation...
  25. The role of cochlear pericytes in control of cochlear microcirculation
    Xiao Rui Shi; Fiscal Year: 2009
    ..of pericyte related-regulatory mechanisms in cochlear blood flow and their involvement in cochlear fluid hemostasis. The volume of cochlear blood flow is extremely small (on the order of 1/1 000 000 of total cardiac output), yet ..
  26. 12-HETrE regulation of platelets
    MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013
    ..2) The importance of DGLA and 12-HETrE in regulation of hemostasis and thrombosis in vivo will also be assessed in wild-type mice and 12-LOX-/- mice who are unable to produce 12-..
  27. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2013
    ..Despite playing a limited role in hemostasis, a variety of data now make a compelling case that fXI contributes to arterial and venous thrombosis and is, ..
  28. Factor XI in Thrombosis
    David Gailani; Fiscal Year: 2013
    ..Factor (f) XI, the zymogen of the coagulation protease fXIa, serves a limited role in normal blood clotting (hemostasis), as fXI deficiency is associated with a relatively mild bleeding tendency...
  29. High throughput assay for fibrin-binding probes
    PETER D CARAVAN; Fiscal Year: 2013
    ..g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis. Beyond hemostasis, it is known that most solid tumors are characterized by the presence of fibrin clots...
  30. Microparticles as Messengers of Communication Between Blood and Vascular Cells
    Richard P Phipps; Fiscal Year: 2010
    ..The small anucleate platelet plays a seminal role not only in hemostasis, but also in diabetes and cardiovascular disease which affect millions of Americans...
  31. Regulation of Pal-1 in Atherosclerosis and Thrombosis
    Yolanda M Fortenberry; Fiscal Year: 2013
    ..field of . ',-. hemostasis and thrombosis. Over the next five years, I wish to expand my basic'science...
  32. Membrane Receptors Regulating Megakaryocyte Endocytosis of Factor V from Plasma
    BETH BOUCHARD; Fiscal Year: 2012
    ..Since platelet-derived factor Va plays a more important role in maintaining normal hemostasis than does its plasma counterpart, and is physically and functionally distinct, these studies will increase our ..
  33. EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATION
    Jay D Humphrey; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The clotting process is fundamental to hemostasis, yet it can also lead to devastating complications in vascular disease progression, compromised interventional procedures, and failure of implanted ..
  34. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..project is to develop an intracavitary hemostatic agent --Hemostatic Adhesive Foam (HAF) --that promotes hemostasis in cases of severe bleeding that would otherwise lead to exsanguination...
  35. Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk
    David C Glahn; Fiscal Year: 2013
    ..blood pressure-related phenotypes, the insulin/glucose axis, inflammatory markers, oxidative stress markers, hemostasis/coagulation factors, and measures of brain white matter hyperintensities that are genetically correlated with ..
  36. Therapeutic Protein C Activator for Myocardial Ischemia
    NORAH VERBOUT; Fiscal Year: 2013
    ..that protects cells from apoptosis, and inhibits blood vessel occlusions without systemic anticoagulation and hemostasis impairment...
  37. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..Platelets are critically involved in hemostasis, thrombosis and inflammation...
  38. Role of Femoral Atherosclerosis in Functional Status, CVD Events, and Mortality
    CHRISTINA LYNN WASSEL; Fiscal Year: 2013
    ..cardiovascular disease (CVD), and total and CVD mortality, and to determine whether endothelial dysfunction, hemostasis, coagulation play important roles in the physiological pathways as mediators...
  39. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul E Bock; Fiscal Year: 2010
    Factor V plays a pivotal role in hemostasis, and in the pathology of venous thrombosis...
  40. Women's Health Study: Continued Follow-Up
    Julie E Buring; Fiscal Year: 2010
    ..sources, DMA from all samples has been extracted and is now undergoing extensive genotyping for markers of hemostasis, thrombosis, and inflammation...
  41. MOLECULAR BASIS OF BLOOD COAGULATION REGULATION
    Steven T Olson; Fiscal Year: 2013
    ..diseases reflect an imbalance in the natural procoagulant and anticoagulant mechanisms that are responsible for hemostasis. Proteins of the serpin superfamily act as critical regulators of this dynamic balance but their molecular ..
  42. MOLECULAR &CELLULAR MECHANISMS IN TRANSFUSION MEDICINE
    Peter J Newman; Fiscal Year: 2013
    ..of signaling proteins that regulate platelet activation and adhesion, with relevance for thrombosis and hemostasis, as well as platelet storage and transfusion therapy...
  43. A diagnostic instrument to manage hemostasis in chronic liver disease
    Francesco Viola; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The clinical evaluation and management of hemostasis in the 5 million patients affected by chronic liver diseases (CLD) is poorly understood...
  44. Hemostatic-antibiotic Combination for Prevention of MRSA Surgical Site Infections
    Timothy C Fisher; Fiscal Year: 2010
    ..Ostene-V is intended to be used for bone hemostasis exactly like Ostene, but will also provide a high local concentration of vancomycin at the surgical site during ..
  45. The role of lectin-complexes in complement-mediated coagulopathy
    Laura R La Bonte; Fiscal Year: 2011
    ..Thus, the purpose of this study is to form a more complete understanding of the role of complement in hemostasis and thrombosis...
  46. Role of Hyperglycemia in Intracerebral Hemorrhage
    Edward P Feener; Fiscal Year: 2013
    ..function of plasma kallikrein in the inhibition of platelet aggregation, which is an early event in establishing hemostasis following cerebral vascular injury...
  47. The role of VWF and platelets in BBB alterations associated with hypoxia
    GEORGETTE LEILA SUIDAN; Fiscal Year: 2013
    ..Platelets are best known for their role in hemostasis and inflammation and the primary ligand for platelet binding to the endothelium and exposed subendothelium is ..
  48. Oral Therapy for Hemophilia A
    Kam W Leong; Fiscal Year: 2013
    ..Thus, oral delivery to the intestinal epithelium can provide both therapy that partially restores hemostasis in animals with hemophilia (thereby providing prophylaxis against spontaneous bleeding) and immune modulation (..
  49. Molecular Mechanisms of the Increased Cardiovascular Risk in Rheumatoid Arthritis
    MARIO CESAR RICO; Fiscal Year: 2013
    ..in bone research and for the last three years has been expanding his experience in the area of thrombosis and hemostasis. Currently he is studying the molecular mechanisms responsible for the increased cardiovascular risk observed in ..
  50. Single molecule measurements on von Willebrand factor A1 and A2 domains
    Timothy A Springer; Fiscal Year: 2013
    ..by applicant): Von Willebrand factor (VWF) is a concatameric plasma glycoprotein that has multiple functions in hemostasis. Mutations in VWF in von Willebrand disease (VWD) are the most common cause of heritable bleeding disorders...
  51. Model of Platelet Adhesion and Thrombus Formation
    Michael R King; Fiscal Year: 2013
    ..Platelets adhesion to sites of vascular injury is a key event not only in the prevention of excessive bleeding (hemostasis) but also in the formation of platelet-rich clots (thrombi) in response to atherosclerotic plaque rupture, which ..
  52. Fibronectin Binding MSCRAMMs
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    ..Fn is a human protein that is very important for human growth and development as well as in maintaining hemostasis. In addition, Fn plays critical roles in inflammation, cancer and wound healing...
  53. Factor XI inhibitor for thrombosis
    ERIK IAN TUCKER; Fiscal Year: 2013
    ..concept since the contribution of FXI to pathological coagulation appears to far outweigh its role in normal hemostasis. Thus, AXIMAB could represent an effective antithrombotic strategy that is exceptionally safe...
  54. Stress, Gene-Environment Interaction and Cardiovascular Disease
    Belinda L Needham; Fiscal Year: 2013
    ..social and psychosocial factors and with biological precursors of cardiovascular disease including inflammation/hemostasis and measures of insulin resistance and adiposity;(2) To examine interactions between cortisol levels and ..
  55. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2010
    ..Platelets play critical roles in hemostasis and its pathophysyology. Undesired platelet activation is a result of many common pathologies, e.g...
  56. Signaling Mechanism of Platelet Glycoprotein Ib-IX
    Xiaoping Du; Fiscal Year: 2013
    ..This process is critical in both hemostasis and thrombosis...
  57. Structural origin of fibrin clot mechanical properties
    John W Weisel; Fiscal Year: 2012
    ..would explain and predict clot behavior in different physiological or pathophysiological conditions related to hemostasis, thrombosis, and wound healing and may lead to new methods of prophylaxis, diagnosis, or treatment...
  58. Molecular Biology and Function of PECAM-1
    Peter J Newman; Fiscal Year: 2013
    ..There is growing appreciation in the fields of thrombosis, hemostasis, and vascular biology that these two pathophysiological conditions are inextricably and mechanistically linked...
  59. Blood Cells in Hemostasis and Thrombosis
    MARK HOWARD GINSBERG; Fiscal Year: 2012
    ..to found an interdisciplinary training program for post-doctoral scientists in the area of blood cells in hemostasis and thrombosis, based in the Division of Hematology-Oncology, to be a centerpiece in an Initiative in Vascular ..
  60. Therapeutic factor XI blockade for sepsis
    ERIK IAN contact TUCKER; Fiscal Year: 2010
    ..new method of anticoagulation because FXI is part of the contact pathway where the molecular mechanisms of hemostasis and thrombosis converge...
  61. 2012 New Insights into Coagulation
    Eleanor Pollak; Fiscal Year: 2012
    ..to choose a timely and pertinent topic to educate clinicians and researchers in the field of thrombosis and hemostasis. This year our topic is new oral anticoagulants. We are pleased to have guest speaker Thomas L...
  62. GENETIC MODULATION OF BLOOD AND VASCULAR GLYCOSYLATION
    NISSI MARY VARKI; Fiscal Year: 2012
    ..Some beta-galactoside-specific lectins detect the selective absence of certain Sias on proteins involved in hemostasis and immune function, affecting their regulation and turnover (Project 1)...
  63. Engineering fibrin polymers for enhanced angiogenesis
    THOMAS HARRISON BARKER; Fiscal Year: 2013
    b>Hemostasis, or the prevention of blood loss, and tissue sealing are of critical importance in response to vascular injury, whether those injuries are a result of traumatic accidents or planned injuries as in the case of surgery...
  64. PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    SANFORD SHATTIL; Fiscal Year: 1993
    During hemostasis, the platelet membrane becomes a conduit for the flow of information into and out of the cell...
  65. BIOLOGIC AND IMMUNOLOGIC ASPECTS OF TRANSFUSION MEDICINE
    Sherrill Slichter; Fiscal Year: 2009
    ..the goal of producing platelets or "platelet-like fragments" that function similarly to platelets in maintaining hemostasis. Dr...
  66. COMPARATIVE STUDY OF COAGULATION AND VASCULAR DISEASE
    WINIFRED DODDS; Fiscal Year: 1993
    ..genetic, biochemical, and physiological studies; production of agents for coagulation tests; and evaluation of hemostasis. These include dos with hemophilia A, hemophilia B, von Willebrand's disease (vWD), factor VII deficiency, ..
  67. MOLECULAR BASIS FOR PLATELET FUNCTION IN HEMOSTASIS
    Robert Colman; Fiscal Year: 2004
    This Program Project, under the direction of Robert W. Coleman, Molecular Basis for Platelet Function in Hemostasis, will exist within the Sol Sherry Thrombosis Research Center of Temple University School of Medicine...
  68. Thrombin signaling in Hemostatis and thrombosis
    Shaun R Coughlin; Fiscal Year: 2010
    A central goal of my laboratory has been to determine how thrombin regulates cellular behaviors involved in hemostasis, thrombosis, inflammation and other processes, and to elucidate the roles of thrombin signaling in vivo...
  69. Novel Protein-Free Material for Minimally Compressive Surgical Hemostasis
    PATRICK STEVEN COTTLER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): "Novel protein-free material for minimally compressive surgical hemostasis" (Patrick S. Cottler, P.I...