erythrocyte deformability

Summary

Summary: Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.

Top Publications

  1. ncbi Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis
    R M Bateman
    Departments of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5B8, Canada
    Am J Physiol Heart Circ Physiol 280:H2848-56. 2001
  2. ncbi Erythrocyte deformability and its variation in diabetes mellitus
    Sehyun Shin
    School of Mechanical Engineering, Kyungpook National University, Daegu 702 701, Korea
    Indian J Exp Biol 45:121-8. 2007
  3. ncbi Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 1:15-30. 2005
  4. ncbi Effects of nitric oxide on red blood cell deformability
    Melek Bor-Kucukatay
    Department of Physiology, Faculty of Medicine, Akdeniz University, Antalya, 07070 Turkey
    Am J Physiol Heart Circ Physiol 284:H1577-84. 2003
  5. ncbi Hemorheological parameters as determinants of myocardial tissue hematocrit values
    O K Baskurt
    Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Clin Hemorheol Microcirc 35:45-50. 2006
  6. pmc Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis
    R E Waugh
    Department of Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642
    J Clin Invest 81:133-41. 1988
  7. pmc Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen
    Innocent Safeukui
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, Departement de Parasitologie Mycologie, Paris, France
    Blood 120:424-30. 2012
  8. ncbi Data reduction methods for ektacytometry in clinical hemorheology
    Oguz K Baskurt
    Koc University School of Medicine, Istanbul, Turkey
    Clin Hemorheol Microcirc 54:99-107. 2013
  9. pmc Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology
    Adam Wieschhaus
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Biochem J 448:141-52. 2012
  10. ncbi Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia
    Maria Koter
    Department of Environment Pollution Biophysics, University of Lodz, 12 16 Banacha St, 90 347, Lodz, Poland
    Int J Biochem Cell Biol 36:205-15. 2004

Research Grants

  1. Monitoring Red Cell Metabolism using a Lab on a Chip
    Dana M Spence; Fiscal Year: 2010
  2. DEFERIPRONE THERAPY FOR SICKLE CELL DISEASE
    Nancy Olivieri; Fiscal Year: 2001
  3. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
  4. Mechanisms of ATP Release from RBC's
    Randy Sprague; Fiscal Year: 2007
  5. UNIQUE AMINO DOMAINS AND AMP DEAMINASE ISOFORM DIVERSITY
    RICHARD SABINA; Fiscal Year: 2002
  6. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2004
  7. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2007

Detail Information

Publications240 found, 100 shown here

  1. ncbi Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis
    R M Bateman
    Departments of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5B8, Canada
    Am J Physiol Heart Circ Physiol 280:H2848-56. 2001
    b>Erythrocyte deformability has been recognized as a determinant of microvascular perfusion...
  2. ncbi Erythrocyte deformability and its variation in diabetes mellitus
    Sehyun Shin
    School of Mechanical Engineering, Kyungpook National University, Daegu 702 701, Korea
    Indian J Exp Biol 45:121-8. 2007
    b>Erythrocyte deformability improves blood flow in the microvessels and in large arteries at high shear rate. The major determinants of RBC deformability include cell geometry, cell shape and internal viscosity (i.e...
  3. ncbi Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 1:15-30. 2005
    ..Some general perspectives on connections among structure, single-cell mechanical properties and biological responses associated with pathogenic processes are also provided in the context of the two diseases considered in this work...
  4. ncbi Effects of nitric oxide on red blood cell deformability
    Melek Bor-Kucukatay
    Department of Physiology, Faculty of Medicine, Akdeniz University, Antalya, 07070 Turkey
    Am J Physiol Heart Circ Physiol 284:H1577-84. 2003
    ..These results thus indicate the importance of NO as a determinant of RBC mechanical behavior and suggest its regulatory role for normal RBC deformability...
  5. ncbi Hemorheological parameters as determinants of myocardial tissue hematocrit values
    O K Baskurt
    Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Clin Hemorheol Microcirc 35:45-50. 2006
    ....
  6. pmc Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis
    R E Waugh
    Department of Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642
    J Clin Invest 81:133-41. 1988
    ..These studies document striking relationships between partial deficiencies of erythrocyte spectrin and specific viscoelastic properties of the mutant membranes...
  7. pmc Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen
    Innocent Safeukui
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, Departement de Parasitologie Mycologie, Paris, France
    Blood 120:424-30. 2012
    ..These results have significant implications for understanding the clinical heterogeneity of RBC membrane disorders...
  8. ncbi Data reduction methods for ektacytometry in clinical hemorheology
    Oguz K Baskurt
    Koc University School of Medicine, Istanbul, Turkey
    Clin Hemorheol Microcirc 54:99-107. 2013
    ..We thus conclude that the SS1/2/EImax ratio can be used when reporting and comparing various populations of RBC or cells obtained from subjects having different clinical states...
  9. pmc Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology
    Adam Wieschhaus
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Biochem J 448:141-52. 2012
    ..The calpain-1 gene deletion results in improved erythrocyte deformability without any measurable effect on erythrocyte lifespan in vivo...
  10. ncbi Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia
    Maria Koter
    Department of Environment Pollution Biophysics, University of Lodz, 12 16 Banacha St, 90 347, Lodz, Poland
    Int J Biochem Cell Biol 36:205-15. 2004
    ..The study involved 60 hypercholesterolemic patients and 30 healthy individuals as the control group...
  11. ncbi The Laser-assisted Optical Rotational Cell Analyzer (LORCA) as red blood cell aggregometer
    M R Hardeman
    Laboratory for Clinical Hemorheology, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Hemorheol Microcirc 25:1-11. 2001
    ..It can be concluded that the aggregometer mode of the LORCA considerably increases the feasibility of this instrument for hemorheological investigations...
  12. pmc Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity
    Barbara Ludolph
    Department of Medicine, Medical Clinic I, University Hospital RTWH Aachen, Germany
    Vasc Health Risk Manag 3:1069-73. 2007
    ..This NO dependent effect of rosuvastatin might have an important influence on microcirculation and may offer new perspectives for the therapeutic use of statins...
  13. pmc The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro
    Guillaume Deplaine
    Unité d Immunologie Moléculaire des Parasites, Departement de Parasitologie Mycologie, Institut Pasteur, Paris, France
    Blood 117:e88-95. 2011
    ..This experimental approach may contribute to a better understanding of the role of the spleen in the pathogenesis of inherited and acquired RBC disorders...
  14. ncbi The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion
    A M Dondorp
    Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, Amsterdam, The Netherlands
    Trans R Soc Trop Med Hyg 96:282-6. 2002
    ..RCD can be improved by blood transfusion. Since severely reduced RCD has a strong predictive value for mortality, blood transfusion possibly improves disease outcome not only through its beneficial effect on anaemia but also on RCD...
  15. ncbi Maximal exercise and lactate do not change red blood cell aggregation in well trained athletes
    Philippe Connes
    UPRES EA 3596 ACTES, Universite des Antilles et de la Guyane, Campus de Fouillole, 97159 Pointe a Pitre, Guadeloupe
    Clin Hemorheol Microcirc 36:319-26. 2007
    ..Py, C. Préfaut, J. Mercier, J.F. Brun and C. Caillaud, Opposite effects of in vitro lactate on erythrocyte deformability in athletes and untrained subjects, Clin. Hemorheol. Microcirc. 31 (2004), 311-318)...
  16. ncbi Parameterization of red blood cell elongation index--shear stress curves obtained by ektacytometry
    Oguz K Baskurt
    Department of Physiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Scand J Clin Lab Invest 69:777-88. 2009
    ..001% and 0.003% GA and 40% rigid, with the SB better for 0.005% GA and the LB better for 10% rigid...
  17. ncbi Quantification of the erythrocyte deformability using atomic force microscopy: correlation study of the erythrocyte deformability with atomic force microscopy and hemorheology
    Xianxian Chen
    The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China
    Clin Hemorheol Microcirc 43:243-51. 2009
    ..Blood samples were taken from 5 diabetes mellitus patients and 5 healthy non-obese people. The erythrocyte deformability was detected by AFM and the hemorheology test, respectively. Excellent correlation (r=0.907, p=0...
  18. ncbi Exercise hemorheology: classical data, recent findings and unresolved issues
    Philippe Connes
    UMR Inserm U665, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe
    Clin Hemorheol Microcirc 53:187-99. 2013
    ..Finally, this review focuses on the effects of exercise training (i.e. chronic physical activity) on the hemorheological profile of healthy individuals and patients with cardiovascular and metabolic disorders...
  19. ncbi Opposite effects of in vitro lactate on erythrocyte deformability in athletes and untrained subjects
    Philippe Connes
    UPRES EA 701 Physiologie des Interactions, Hopital Arnaud de Villeneuve, Service EFR, 34295 Montpellier Cedex 5, France
    Clin Hemorheol Microcirc 31:311-8. 2004
    ..05). Thus, it seems that endurance training influences erythrocyte response to lactate. Lactate impaired erythrocyte deformability in untrained subjects but it (unexpectedly) improved it in trained subjects...
  20. ncbi Modulation of erythrocyte deformability by PKC activity
    Sofia de Oliveira
    Instituto de Bioquimica, Unidade Biologia Microvascular e Inflamacao, Instituto de Medicina Moecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    Clin Hemorheol Microcirc 39:363-73. 2008
    ..between membrane, peripheral and cytoskeleton proteins are responsible for the maintenance of erythrocyte deformability (EEI) and some of these interactions are modulated by PKC activity...
  21. pmc A multiscale red blood cell model with accurate mechanics, rheology, and dynamics
    Dmitry A Fedosov
    Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA
    Biophys J 98:2215-25. 2010
    ..Our findings clearly indicate that a purely elastic model for the membrane cannot accurately represent the RBC's rheological properties and its dynamics, and therefore accurate modeling of a viscoelastic membrane is necessary...
  22. ncbi Time course of hemorheological alterations after heavy anaerobic exercise in untrained human subjects
    Ozlem Yalcin
    Department of Physiology, Akdeniz University School of Medicine, and School of Physical Education and Sports, Akdeniz University, Antalya, Turkey 07070
    J Appl Physiol 94:997-1002. 2003
    ....
  23. ncbi Adenosine transport, erythrocyte deformability and microvascular dysfunction: an unrecognized potential role for dipyridamole therapy
    Jignesh Bhavsar
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
    Clin Hemorheol Microcirc 44:193-205. 2010
    ..In addition, it has anti-oxidant and anti-inflammatory properties that provide protection to the microvasculature. This review discusses the potential role for dipyridamole therapy in the treatment of microvascular dysfunction...
  24. ncbi On-chip erythrocyte deformability test under optical pressure
    Won Gu Lee
    School of Mechanical and Aerospace Engineering, Seoul National University, San 56 1 Shinlim, Kwanak, Seoul 151 742, South Korea
    Lab Chip 7:516-9. 2007
    This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect to the detection of cancerous diseases...
  25. ncbi Ethanol improves decreased filterability of human red blood cells through modulation of intracellular signaling pathways
    T Oonishi
    NTT Medical Research Institute, Kanto Teishin Hospital, Tokyo, Japan
    Alcohol Clin Exp Res 24:352-6. 2000
    ..We examined the effect of ethanol on deformability at the physiologically achievable concentrations...
  26. ncbi Effects of acetylcholine and spermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
    R Mesquita
    Institute of Biochemistry, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Clin Hemorheol Microcirc 25:153-63. 2001
    ..To determine the effects of acetylcholine and spermineNONOate--a NO donor--on RBC membrane and oxygen carrying properties...
  27. ncbi Effect of ethanol on hemorheology in patients with ischemic cerebrovascular disease and elderly healthy men
    Y Nagai
    5th Department of Internal Medicine, School of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka City 814 0180, Japan
    Clin Hemorheol Microcirc 25:135-44. 2001
    ..It is considered that ethanol ingestion could has bad influences for the microcirculation in patients with ischemic cerebrovascular disease...
  28. ncbi In vitro hemorheological effects of red wine and alcohol-free red wine extract
    M Rabai
    Department of Medicine, University of Pecs Medical School, Pecs, Hungary
    Clin Hemorheol Microcirc 44:227-36. 2010
    ..LORCA aggregation index and threshold shear rate supported these results at the highest concentration. Erythrocyte deformability of healthy volunteers did not change significantly for any concentrations of red wine and AFRW...
  29. ncbi Is hemoglobin desaturation related to blood viscosity in athletes during exercise?
    P Connes
    UPRES EA 2991 Sport, Performance et Santé, Montpellier, France
    Int J Sports Med 25:569-74. 2004
    ..Whether this could impair the blood gas barrier and result in exercise-induced hypoxemia requires further study...
  30. ncbi Protective effect of alpha-tocotrienol against free radical-induced impairment of erythrocyte deformability
    Aynun Nahar Begum
    Department of Nutrition, School of Medicine, The University of Tokushima, Japan
    Biosci Biotechnol Biochem 66:398-403. 2002
    ..This study was done to estimate the effect of alpha-T3 on free radical-induced impairment of erythrocyte deformability by comparing it to alpha-tocopherol (alpha-T)...
  31. ncbi Reciprocal relationships between blood lactate and hemorheology in athletes: another hemorheologic paradox?
    Emmanuelle Varlet-Marie
    Laboratoire de Pharmacocinetique Clinique, Faculte de Pharmacie, Universite Montpellier I, France
    Clin Hemorheol Microcirc 30:331-7. 2004
    ..While lactate did not in vitro affect erythrocyte aggregation, it impaired (as expected) erythrocyte deformability in sedentary subjects but it (unexpectedly) improved it in trained subjects...
  32. ncbi Role of erythrocyte deformability during capillary wetting
    Ronghui Zhou
    Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Illinois 46556, USA
    Biotechnol Bioeng 93:201-11. 2006
    ..This tightly packed slug had a high hydrodynamic resistance that could arrest the penetrating flow of concentrated suspensions into the small capillaries...
  33. pmc Simulations of the erythrocyte cytoskeleton at large deformation. II. Micropipette aspiration
    D E Discher
    University of Pennsylvania, Philadelphia 19104 6315, USA
    Biophys J 75:1584-97. 1998
    ....
  34. ncbi Assessment of oxidant susceptibility of red blood cells in various species based on cell deformability
    Michael J Simmonds
    Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia
    Biorheology 48:293-304. 2011
    ..These differences in susceptibility are consistent with species-specific discrepancies between observed and allometrically-predicted life spans and are compatible with the oxidant theory of aging...
  35. ncbi Erythrocyte deformability dependence on band 3 protein in an in-vitro model of hyperfibrinogenemia
    J P Lopes de Almeida
    University of Lisbon Medical School, Santa Maria Hospital, Lisbon, Portugal
    Clin Hemorheol Microcirc 50:213-9. 2012
    ..control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the erythrocyte deformability was determined...
  36. ncbi Vitamin E treatment enhances erythrocyte deformability in aged rats
    V Kucukatay
    Pamukkale University, Faculty of Medicine, Department of Physiology, Kinikli, Denizli, Turkey
    Folia Biol (Praha) 58:157-65. 2012
    ....
  37. ncbi Erythrocyte deformability and oxidative stress in inflammatory bowel disease
    Tulay Akman
    Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
    Dig Dis Sci 57:458-64. 2012
    ..The increased oxidative stress reduces the erythrocyte deformability. However, in IBD, there are no studies in the literature which evaluate erythrocyte deformability.
  38. ncbi Ethanol and erythrocyte membrane interaction: a hemorheologic perspective
    R Mesquita
    Instituto de Bioquimica, Faculdade de Medicina de Lisboa, Portugal
    Clin Hemorheol Microcirc 21:95-8. 1999
    ..310 Osm/kg H2O; p < 0.001) were obtained. In conclusion, ethanol only changes erythrocyte aggregation for a concentration of 67 mM. These data could lead to future changes in therapeutic approaches to situations such as alcoholic coma...
  39. ncbi Effect of carnosine on erythrocyte deformability in diabetic rats
    Hande Yapislar
    Istanbul Bilim University Medical Faculty Physiology Department, 34394, Istanbul, Turkey
    Arch Physiol Biochem 118:265-72. 2012
    ..Lipid peroxidation is one of the consequences of oxidative stress. Erythrocyte deformability abilities are reduced as a result of lipid peroxidation...
  40. pmc Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration
    Steven M Frank
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Anesth Analg 116:975-81. 2013
    ..We assessed erythrocyte cell membrane deformability in patients before and after transfusion to determine the effects of storage duration and whether changes in deformability are reversible after transfusion...
  41. ncbi Effect of antioxidant vitamin treatment on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects
    Umit K Senturk
    Dept of Physiology, Akdeniz Univ, Faculty of Medicine, Kampus, Antalya, Turkey
    J Appl Physiol 98:1272-9. 2005
    ....
  42. ncbi Effects of resistance training intensity on deformability and aggregation of red blood cells
    Hayriye Cakir-Atabek
    School of Physical Education and Sports, Anadolu University, Eskisehir, Turkey
    Clin Hemorheol Microcirc 41:251-61. 2009
    ..It is concluded that RET performed at an intensity corresponding to 70% of 1RM alters RBC deformability more than training performed at 85% of 1RM. On the other hand, both training protocols affect RBC aggregation in a similar way...
  43. ncbi Effects of different levels of compression during sub-maximal and high-intensity exercise on erythrocyte deformability
    Patrick Wahl
    Institute of Training Science and Sport Informatics, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany
    Eur J Appl Physiol 112:2163-9. 2012
    ..was to test the hypothesis whether different levels of sock compression (0, 10, 20, and 40 mmHg) affect erythrocyte deformability and metabolic parameters during sub-maximal and maximal running...
  44. pmc A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages
    Marta Tibúrcio
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    Blood 119:e172-80. 2012
    ..These processes are proposed to play a key role in P falciparum gametocyte development in the host and to represent novel and unconventional targets for interfering with parasite transmission...
  45. ncbi The measurement of shear modulus and membrane surface viscosity of RBC membrane with Ektacytometry: a new technique
    Xiao Liu
    Department of Mechanics and Engineering Sciences, Peking University, Beijing 100871, PR China
    Math Biosci 209:190-204. 2007
    ..The sensitivity of the technique is demonstrated by testing RBCs treated with glutaraldehyde of different concentrations. This technique was demonstrated by the flow chamber...
  46. ncbi Leukocyte activation, oxidant stress and red blood cell properties after acute, exhausting exercise in rats
    A Temiz
    Department of Biophysics, School of Medicine, Dokuz Eylul University, Balcova Izmir, Turkey
    Clin Hemorheol Microcirc 22:253-9. 2000
    ..As a conclusion the results imply that activated leukocytes might play role in the RBC damage observed after exhausting exercise encouraging oxidative stress...
  47. ncbi The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release
    Alison M Forsyth
    Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA
    Microvasc Res 83:347-51. 2012
    ..We also found that simvastatin increases deformability by acting directly on the membrane in the absence of the liver, and that ATP release was increased for cells with enriched cholesterol after treatment with simvastatin...
  48. pmc Erythrocyte adducin: a structural regulator of the red blood cell membrane
    T Franco
    Department of Chemistry, Purdue University, 560, Oval Drive, West Lafayette, IN 47907 2084, USA
    Transfus Clin Biol 17:87-94. 2010
    ..The text below summarizes the structural properties of adducin, its multiple functions in erythrocytes, and the consequences of engineered deletions of each of adducin subunits in transgenic mice...
  49. ncbi Theoretical model and experimental study of red blood cell (RBC) deformation in microchannels
    Natanel Korin
    Biomedical Engineering Department, Technion, Haifa 32000, Israel
    J Biomech 40:2088-95. 2007
    ..The system and the model have the potential of serving as quantitative clinical tools for diagnosing deformability disorders in RBCs...
  50. ncbi The influence of calcium ions and ionophore A23187 on microrheological characteristics of erythrocytes by new model ektacytometry
    W Chunyi
    Biomechanics and Medical Information Institute of Beijing Polytechnic University, PR. China
    Clin Hemorheol Microcirc 24:19-23. 2001
    ..Furthermore, the effect of ionophore A23187 on the microrheology of erythrocytes is more notable than that of intercellular Ca2+...
  51. ncbi Reduction of red blood cell disaggregability during submaximal exercise: relationship with fibrinogen levels
    E Varlet-Marie
    Laboratoire de Pharmacocinetique Clinique, Faculte de Pharmacie, Universite Montpellier I, France
    Clin Hemorheol Microcirc 28:139-49. 2003
    ..Thus, laser backscattering demonstrates an increase in aggregability and a decrease in disaggregability of red cells during exercise, proportional to baseline fibrinogen values...
  52. ncbi Optical measurement of cell membrane tension
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev Lett 97:218101. 2006
    ..This is consistent with the cytoskeleton confinement model, in which the cytoskeleton inhibits membrane fluctuations [Gov et al., Phys. Rev. Lett. 90, 228101, (2003)...
  53. ncbi Abnormal blood flow and red blood cell deformability in severe malaria
    A M Dondorp
    Department of Internal Medicine, Tropical Medicine and AIDS, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Parasitol Today 16:228-32. 2000
    ..The correlation with clinical findings and possible therapeutic consequences are discussed...
  54. ncbi Determination of erythrocyte deformability and its correlation to cellular ATP release using microbore tubing with diameters that approximate resistance vessels in vivo
    David J Fischer
    Department of Chemistry, Saint Louis University, St Louis, MO 63103, USA
    Analyst 128:1163-8. 2003
    ..This method greatly simplifies deformability measurements, employing only a syringe pump and microbore tubing, and may lead to a more complete understanding of the physiological significance of erythrocyte deformability.
  55. ncbi Erythrocyte aggregation in rheumatoid arthritis: Cell and plasma factor's role
    A Luquita
    Cátedra de Física Biológica, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina
    Clin Hemorheol Microcirc 41:49-56. 2009
    ....
  56. ncbi Blood rheology abnormalities and vascular cell adhesion mechanisms in sickle cell trait carriers during exercise
    Philippe Connes
    Laboratoire ACTES EA 3596, Departement de Physiologie, Universite des Antilles et de la Guyane, Guadeloupe, France
    Clin Hemorheol Microcirc 39:179-84. 2008
    ..Therefore, we can suggest that the risks for microvascular complications in SCT carriers in response to exercise could be dependent on alterations in blood rheology and vascular adhesion processes...
  57. ncbi Exercise-induced oxidative stress affects erythrocytes in sedentary rats but not exercise-trained rats
    U K Senturk
    Department of Physiology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    J Appl Physiol (1985) 91:1999-2004. 2001
    ..concentrations, methemoglobin levels, and rise in osmotic fragility of erythrocytes with decrease in erythrocyte deformability)...
  58. pmc Assessment of erythrocyte shape by flow cytometry techniques
    M Piagnerelli
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Clin Pathol 60:549-54. 2007
    ..Several techniques are available to assess alterations in RBC rheology, especially deformability, but they are too cumbersome to be used on a large number of cells...
  59. ncbi HNE produced by the malaria parasite Plasmodium falciparum generates HNE-protein adducts and decreases erythrocyte deformability
    Aleksei Skorokhod
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Redox Rep 12:73-5. 2007
    ....
  60. ncbi Tumorigenesis of murine erythroleukemia cell line transfected with exogenous p53 gene
    Dagong Sun
    Hemorheology Center, Department of Medical Physics, School of Basic Medical Sciences, Peking University, Health Science Center, Beijing 100083, China
    Clin Hemorheol Microcirc 30:117-26. 2004
    ..The results of animal test and micropipette suggest that exogenous wild-type p53 gene could reduce the tumorigenesis of murine erythroleukemia cells...
  61. ncbi Negative air ions created by water shearing improve erythrocyte deformability and aerobic metabolism
    H Iwama
    Department of Anesthesiology, Central Aizu General Hospital, Aizuwakamatsu City, Japan
    Indoor Air 14:293-7. 2004
    ..by which negative air ions improve aerobic metabolism, changes in venous blood lactate levels, pH, erythrocyte deformability, and plasma superoxide dismutase activity and ceruloplasmin levels were examined during a 1-h exposure ..
  62. ncbi Asymmetric dimethylarginine reduced erythrocyte deformability in streptozotocin-induced diabetic rats
    Zhi Chun Yang
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Xiang Ya Road 110, Changsha 410078, China
    Microvasc Res 73:131-6. 2007
    To investigate the effect of asymmetric dimethylarginine on erythrocyte deformability in streptozotocin-induced diabetic rats, a single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg) in male Sprague-Dawley rats was carried ..
  63. pmc A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes
    J Patrick Shelby
    Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195 1700, USA
    Proc Natl Acad Sci U S A 100:14618-22. 2003
    ..The last observation can explain the high parasitemia in a growing capillary blockage and the well known benefits of early blood transfusion in severe malaria...
  64. ncbi Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases
    Adrian Pistea
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Vasc Res 45:10-8. 2008
    Hypertension is associated with inward remodeling of small arteries and decreased erythrocyte deformability, both impairing proper tissue perfusion...
  65. pmc A microfabricated deformability-based flow cytometer with application to malaria
    Hansen Bow
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 841, Cambridge, MA 02139, USA
    Lab Chip 11:1065-73. 2011
    ..These methods collectively provide a systematic approach to characterize the biomechanical properties of cells in a high-throughput manner...
  66. ncbi Influence of storage on red blood cell rheological properties
    Tamara L Berezina
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Surg Res 102:6-12. 2002
    ..We assumed that blood storage was accompanied by a progressive decrease of RBC deformability and rheological disorders. The degree of rheological disturbances should be directly proportional to the number of RBC with altered geometry...
  67. ncbi Measurement of the distribution of red blood cell deformability using an automated rheoscope
    J G G Dobbe
    Department of Medical Technological Development, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cytometry 50:313-25. 2002
    ..A deformability distribution would be more useful for studying diseases that are marked by subpopulations of less deformable cells because even small fractions of rigid cells can cause circulatory problems...
  68. ncbi Greater erythrocyte deformability in world-class endurance athletes
    J A Smith
    Department of Physical Therapy, Tennessee State University, Nashville, Tennessee 37209 1561, USA
    Am J Physiol 276:H2188-93. 1999
    ..Furthermore, examination of factors that contribute to increased RBC turnover in athletes may help us understand the mechanisms that cause RBC aging...
  69. ncbi Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients
    Lucia Mannini
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
    Clin Hemorheol Microcirc 35:175-81. 2006
    ..512 s(-1) and 94.5 s(-1), plasma viscosity (PLV) at 94.5 s(-1) shear rate, erythrocyte deformability index (DI) and PFA-100 closure times with ADP (PFA/ADP) and epinephrine (PFA/EPI)...
  70. ncbi Blood banking-induced alteration of red blood cell flow properties
    Hanna Relevy
    Blood Bank, Hadassah University Hospital, Jerusalem, Israel
    Transfusion 48:136-46. 2008
    ..This study was undertaken to comprehensively explore the effect of cold storage and gamma irradiation on RBC flow properties...
  71. ncbi Differential effect of cold acclimation on blood composition in rats and hamsters
    D Deveci
    Cumhuriyet University, Department of Physiology School of Medicine, Sivas, Turkey
    J Comp Physiol B 171:135-43. 2001
    ..These data suggest that blood composition in hamsters contributes to an innate tolerance of low temperatures, maintaining tissue perfusion under hypothermic conditions and aiding arousal from hibernation...
  72. ncbi Direct measurement of erythrocyte deformability in diabetes mellitus with a transparent microchannel capillary model and high-speed video camera system
    K Tsukada
    Institute of Biomedical Engineering, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, 223-8522, Japan
    Microvasc Res 61:231-9. 2001
    To measure erythrocyte deformability in vitro, we made transparent microchannels on a crystal substrate as a capillary model...
  73. ncbi Erythrocyte deformability, plasma viscosity and oxidative status in patients with severe obstructive sleep apnea syndrome
    Neslihan Dikmenoglu
    Department of Physiology, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey
    Sleep Med 7:255-61. 2006
    In patients with severe obstructive sleep apnea syndrome (OSAS), diurnal changes of plasma viscosity and erythrocyte deformability were measured to elucidate the possible mechanism of cardiovascular diseases in OSAS patients.
  74. ncbi Effects of storage duration and temperature of human blood on red cell deformability and aggregation
    Mehmet Uyuklu
    Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Clin Hemorheol Microcirc 41:269-78. 2009
    ..Therefore, the time period between sampling and measurement should be as short as possible and reported together with results...
  75. ncbi Influence of temperature variation from 5 degrees C to 37 degrees C on aggregation and deformability of erythrocytes
    Megha Singh
    Biomedical Engineering Division, Indian Institute of Technology, Madras 600036, India
    Clin Hemorheol Microcirc 26:1-7. 2002
    ..These show significant to highly significant changes with the increase of temperature compared to that at 5 degrees C. The EI increases with the increase of shear stress but shows significant decrease with the decrease of temperature...
  76. ncbi Influence of temperature on rheology of human erythrocytes
    K L Sung
    Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093 0412
    Chin J Physiol 35:81-94. 1992
    ..These responses to temperature variations provide insights into the viscoelastic properties of the erythrocyte membrane...
  77. ncbi Erythrocyte oxidative damage in chronic fatigue syndrome
    Ross S Richards
    School of Community Health, Faculty of Health Sciences, Charles Sturt University, NSW, Australia
    Arch Med Res 38:94-8. 2007
    ..metabolism (particularly redox metabolism) and erythrocyte shape and that both are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation ..
  78. ncbi Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes
    Jeffrey J Olearczyk
    Dept of Pharmacological and Physiological Science, St Louis Univ School of Medicine, M 208, St Louis, MO 63104, USA
    Am J Physiol Heart Circ Physiol 286:H940-5. 2004
    ..These data are consistent with the hypothesis that the heterotrimeric G protein G(i) is a component of a signal transduction pathway for ATP release from erythrocytes...
  79. ncbi Red blood cell deformability in sepsis
    O K Baskurt
    Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles 90033, USA
    Am J Respir Crit Care Med 157:421-7. 1998
    ..We conclude that RBC deformability is reduced in sepsis but that micropore bulk-filtration methods may not be appropriate for detecting these changes...
  80. ncbi Association of reduced red blood cell deformability and diabetic nephropathy
    Clinton D Brown
    Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Kidney Int 67:295-300. 2005
    ..The present study was conducted to test whether impaired red blood cell deformability is indeed associated with development of diabetic nephropathy...
  81. ncbi Influence of adsorbed plasma proteins on erythrocyte rheological properties: in vitro and ex vivo studies
    A Luquita
    Cátedra de Física Biológica, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina
    Pflugers Arch 443:78-83. 2001
    ..The first is the well known decrease in plasma viscosity, and the second is an improvement of erythrocyte deformability, as has been shown in this work...
  82. ncbi Techniques to evaluate erythrocyte deformability in diabetes mellitus
    G Caimi
    Department of Lateral Medicine, Cardiovascular Disease and Nephrology, University of Palermo, Palermo, Italy
    Acta Diabetol 41:99-103. 2004
    Using several rheological techniques, we examined erythrocyte deformability in different groups of diabetic subjects...
  83. ncbi Allopurinol prevents erythrocyte deformability impairing but not the hematological alterations after limb ischemia-reperfusion in rats
    Norbert Nemeth
    Department of Operative Techniques and Surgical Research, Medical and Health Science Center, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
    J Invest Surg 19:47-56. 2006
    ..Measurement of erythrocyte deformability using a bulk filtrometer with special setting of cell suspension hematocrit (1%), and determination of ..
  84. ncbi Impaired erythrocyte deformability precedes vascular changes in experimental diabetes mellitus
    E J Diamantopoulos
    4th Department of Internal Medicine, Evangelismos State General Hospital, Athens, Greece
    Horm Metab Res 36:142-7. 2004
    ..The results of this study indicate that reduced RBC deformability is an early manifestation of abnormal blood rheology in experimental diabetes, and precedes the evolution of vascular changes...
  85. ncbi Evidence for a mechanosensitive calcium influx into red cells
    Michael C Brain
    Department of Biochemistry and Molecular Biology, University of Calgary, Room 388 Heritage Research Building, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Blood Cells Mol Dis 32:349-52. 2004
    ..Red cells containing hemoglobin AC and AS had enhanced calcium responses to filtration. An increased influx of calcium in hemoglobin disorders might play a role in providing protection against Falciparum malaria...
  86. ncbi Direct measurement of the impact of impaired erythrocyte deformability on microvascular network perfusion in a microfluidic device
    Sergey S Shevkoplyas
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    Lab Chip 6:914-20. 2006
    ..The direct measurement of microchannel network perfusion represents a new concept for the field of blood rheology and should prove beneficial for basic science and clinical applications...
  87. ncbi The microrheological behavior of young and old red blood cells in athletes
    A V Muravyov
    Department of Medicine and Biology, Yaroslavl University, Yaroslavl, Russia
    Clin Hemorheol Microcirc 26:183-8. 2002
    ..It was one of the cause of high fluidity of the RBCtop- and RBCbot suspensions and whole blood in athletes and more effective oxygen transport than in untrained people...
  88. ncbi Endotoxin binding to erythrocyte membrane and erythrocyte deformability in human sepsis and in vitro
    Johannes M B Pöschl
    Division of Neonatology, Department of Pediatrics, University of Heidelberg Medical School, Germany
    Crit Care Med 31:924-8. 2003
    ..However, it is unclear whether impaired red blood cell deformability is associated with binding of lipopolysaccharide to the red blood cell membrane...
  89. ncbi Impairment of erythrocyte viscoelasticity is correlated with levels of glycosylated haemoglobin in diabetic patients
    A Symeonidis
    Haematology Division, Department of Internal Medicine, University of Patras Medical School, 261 10, Patras, Greece
    Clin Lab Haematol 23:103-9. 2001
    ..Our findings suggest that glycosylation of skeletal proteins probably contributes significantly to the increased membrane rigidity of diabetic erythrocytes...
  90. ncbi Effect of blood hematocrit and erythrocyte deformability on adenosine 5'-diphosphate platelet reactivity in patients with acute coronary syndromes on dual antiplatelet therapy
    Emanuele Cecchi
    Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Am J Cardiol 104:764-8. 2009
    ..512 and 94.5/second, plasma viscosity, and erythrocyte deformability index...
  91. ncbi Prohemorrhagic potential of dipyrone, ibuprofen, ketorolac, and aspirin: mechanisms associated with blood flow and erythrocyte deformability
    J Bozzo
    Department of Hemotherapy and Hemostasis, Hospital Clinic, Barcelona, Spain
    J Cardiovasc Pharmacol 38:183-90. 2001
    ..In addition, aspirin significantly reduced erythrocyte deformability with respect to the other drugs...
  92. ncbi Effects of alpha 1-acid glycoprotein on erythrocyte deformability and membrane stabilization
    Kazuaki Matsumoto
    Faculty of Pharmaceutical Sciences, Kumamoto University, 5 2 Oe honmachi, Kumamoto 862 0973, Japan
    Biol Pharm Bull 26:123-6. 2003
    ..A new technique developed by Kikuchi was used to investigate erythrocyte deformability. The addition of AGPs including human AGP facilitated the passage of human erythrocytes with an average ..
  93. ncbi Measurement temperature plays a pivotal role in the distribution of erythrocyte deformability after LPS
    J E Jagger
    The A.C. Burton Vascular Biology Laboratory, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biorheology 38:439-48. 2001
    ..We have shown that LPS incubation results in a significant decrease in RBC(D) and that room temperature measurement of physical membrane properties may exaggerate the differences between normal and perturbed RBCs...
  94. ncbi Hemorheologic effects of low intensity endurance training in sedentary patients suffering from the metabolic syndrome
    Ikram Aloulou
    Universite Montpellier 1, UFR de Medecine, Laboratoire de Physiologie des Interactions, Montpellier Institut de Biologie, Boulevard Henri IV, F 34062 France
    Clin Hemorheol Microcirc 35:333-9. 2006
    ..For which reason Hct increased in 30% of the patients during this kind of training remains unclear...
  95. ncbi Fetal hemorheology in normal pregnancy and severe preeclampsia
    L Heilmann
    Department Obstetrics Gynecology, Clinica Obstetric Gynecology, City Hospital, Russelsheim, Germany
    Clin Hemorheol Microcirc 32:183-90. 2005
    ..9%. An elevated red cell aggregation was found in 2.8% (stasis) and 4.8% (low flow state), respectively. We conclude that in fetal blood the higher hematocrit and the presence of larger red cells do not cause impaired fetal hemorheology...
  96. ncbi [Clinical efficacy of a novel hemorheological drug ascovertin in patients with vascular encephalopathy]
    M B Plotnikov
    Zh Nevrol Psikhiatr Im S S Korsakova 104:33-7. 2004
    ..blood viscosity due to improvement of cellular rheology indices (decrease of aggregation and increase of erythrocyte deformability as well as decrease of indices of lipid peroxidation in erythrocyte membrane and blood plasma) was ..
  97. ncbi Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children
    Ulf Kessler
    Department of Surgical Pediatrics, University of Bern Inselspital, 3010 Bern, Switzerland
    Pediatr Surg Int 21:197-202. 2005
    ..Vasoconstriction rather than hemorheological changes during infusion of IL may play a crucial role in the pathogenesis of circulatory alterations in parenterally-fed neonates...
  98. ncbi Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 405, La Jolla, CA 92037, USA
    Am J Physiol Heart Circ Physiol 293:H1206-15. 2007
    ....
  99. ncbi In vivo effect of aluminium upon the physical properties of the erythrocyte membrane
    Graciela B Bazzoni
    Cátedra de Física Biológica, Facultad de Cs Médicas, Universidad Nacional de Rosario, 3100, 2000 Rosario, Republica Argentina
    J Inorg Biochem 99:822-7. 2005
    ..In conclusion, Al (III) disorganised the erythrocyte membrane by altering its mechanical properties, suggesting a reduction of the middle life of circulating erythrocytes, which could play a major role in the anaemia of these animals...
  100. ncbi [Effect of qilong capsule on hemoreology in acute stress blood stasis rats]
    Yan Wu
    Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China
    Zhongguo Zhong Yao Za Zhi 29:362-5. 2004
    ..To study the influence of Qilong capsule (QLC) on the hemoreology in acute stress blood stasis model rats...
  101. ncbi Capillary blood viscosity in microcirculation
    A Cortinovis
    Dipartimento di Medicina Interna e Terapia Medica, Sez di Clinica Medica 2, Universita degli Studi di Pavia, IRCCS Policlinico S Matteo, Italy
    Clin Hemorheol Microcirc 35:183-92. 2006
    ..Moreover, the percentage ratio between the GBV and the CBV gives a physical measure of erythrocyte deformability. Knowing viscosity at shear-rate present in the circulatory system, we can obtain the size of RBCs ..

Research Grants7

  1. Monitoring Red Cell Metabolism using a Lab on a Chip
    Dana M Spence; Fiscal Year: 2010
    ..Recently, it has been demonstrated that erythrocyte deformability is a determinant of deformation-induced release of adenosine triphosphate (ATP)...
  2. DEFERIPRONE THERAPY FOR SICKLE CELL DISEASE
    Nancy Olivieri; Fiscal Year: 2001
    ..induce protein thiol oxidation and lipid peroxidation leading to cation leak, cell dehydration, reduced erythrocyte deformability, and premature red cell destruction...
  3. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
    ..abstract_text> ..
  4. Mechanisms of ATP Release from RBC's
    Randy Sprague; Fiscal Year: 2007
    ..abstract_text> ..
  5. UNIQUE AMINO DOMAINS AND AMP DEAMINASE ISOFORM DIVERSITY
    RICHARD SABINA; Fiscal Year: 2002
    ..These combined efforts should provide critical information that may help explain clinical outcomes associated with a prevalent AMPD1 mutant allele. ..
  6. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2004
    ..abstract_text> ..
  7. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2007
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. [unreadable] [unreadable]..