blood viscosity

Summary

Summary: The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.

Top Publications

  1. pmc Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease
    Julien Tripette
    Laboratoire ACTES, EA 3596, Departement de Physiologie, Universite des Antilles et de la Guyane, Campus de Fouillole, Pointe a Pitre, Guadeloupe, French West Indies
    Haematologica 94:1060-5. 2009
  2. ncbi Blood rheology and hemodynamics
    Oguz K Baskurt
    Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Semin Thromb Hemost 29:435-50. 2003
  3. ncbi Erythrocyte aggregation: basic aspects and clinical importance
    Oguz K Baskurt
    Koc University School of Medicine, Istanbul, Turkey
    Clin Hemorheol Microcirc 53:23-37. 2013
  4. pmc Predicting human blood viscosity in silico
    Dmitry A Fedosov
    Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Julich, 52425 Julich, Germany
    Proc Natl Acad Sci U S A 108:11772-7. 2011
  5. pmc Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation
    Danitza Nebor
    Inserm U763, Pointe a Pitre, Guadeloupe
    Haematologica 96:1589-94. 2011
  6. ncbi Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
  7. ncbi Erythrocyte transport efficacy of human blood: a rheological point of view
    L Bogar
    University of Pecs, Pecs, Hungary
    Eur J Clin Invest 35:687-90. 2005
  8. ncbi Exercise hemorheology: classical data, recent findings and unresolved issues
    Philippe Connes
    UMR Inserm U665, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe
    Clin Hemorheol Microcirc 53:187-99. 2013
  9. ncbi The acute effects of resistance exercise on the main determinants of blood rheology
    Sajad Ahmadizad
    Faculty of Science, School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    J Sports Sci 23:243-9. 2005
  10. ncbi Rheopheresis for idiopathic sudden hearing loss: results from a large prospective, multicenter, randomized, controlled clinical trial
    Ralph Mosges
    Institute of Medical Statistics, Informatics und Epidemiology, University of Cologne, Lindenburger Allee 42, 50931, Cologne, Germany
    Eur Arch Otorhinolaryngol 266:943-53. 2009

Detail Information

Publications252 found, 100 shown here

  1. pmc Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease
    Julien Tripette
    Laboratoire ACTES, EA 3596, Departement de Physiologie, Universite des Antilles et de la Guyane, Campus de Fouillole, Pointe a Pitre, Guadeloupe, French West Indies
    Haematologica 94:1060-5. 2009
    Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation...
  2. ncbi Blood rheology and hemodynamics
    Oguz K Baskurt
    Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Semin Thromb Hemost 29:435-50. 2003
    ..Impairment of blood fluidity may significantly affect tissue perfusion and result in functional deteriorations, especially if disease processes also disturb vascular properties...
  3. ncbi Erythrocyte aggregation: basic aspects and clinical importance
    Oguz K Baskurt
    Koc University School of Medicine, Istanbul, Turkey
    Clin Hemorheol Microcirc 53:23-37. 2013
    ..The extent of aggregation is the main determinant of low shear blood viscosity, thus predicting an inverse relationship between aggregation and in vivo blood flow...
  4. pmc Predicting human blood viscosity in silico
    Dmitry A Fedosov
    Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Julich, 52425 Julich, Germany
    Proc Natl Acad Sci U S A 108:11772-7. 2011
    ..molecular dynamics and two different red blood cell models, we accurately predict the dependence of blood viscosity on shear rate and hematocrit...
  5. pmc Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation
    Danitza Nebor
    Inserm U763, Pointe a Pitre, Guadeloupe
    Haematologica 96:1589-94. 2011
    ..The aim of the present study was to compare the autonomic nervous system activity, blood rheology, and inflammation in patients with sickle cell anemia according to the frequency of acute pain crisis...
  6. ncbi Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
    ....
  7. ncbi Erythrocyte transport efficacy of human blood: a rheological point of view
    L Bogar
    University of Pecs, Pecs, Hungary
    Eur J Clin Invest 35:687-90. 2005
    ..It was previously noted that delineating the corresponding haematocrit/blood viscosity ratios in the function of haematocrit provided a distribution of an inverted U-shaped curve...
  8. ncbi Exercise hemorheology: classical data, recent findings and unresolved issues
    Philippe Connes
    UMR Inserm U665, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe
    Clin Hemorheol Microcirc 53:187-99. 2013
    ..Acute exercise is associated with a rise in hematocrit which results in an increase in blood viscosity. Whereas increased blood viscosity was previously viewed as having negative consequences for cardiovascular ..
  9. ncbi The acute effects of resistance exercise on the main determinants of blood rheology
    Sajad Ahmadizad
    Faculty of Science, School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    J Sports Sci 23:243-9. 2005
    ....
  10. ncbi Rheopheresis for idiopathic sudden hearing loss: results from a large prospective, multicenter, randomized, controlled clinical trial
    Ralph Mosges
    Institute of Medical Statistics, Informatics und Epidemiology, University of Cologne, Lindenburger Allee 42, 50931, Cologne, Germany
    Eur Arch Otorhinolaryngol 266:943-53. 2009
    ..Also, this may be a second line treatment option for patients refractory to i.v. corticosteroids or hemodilution...
  11. ncbi Morning increase of whole blood viscosity in obstructive sleep apnea syndrome
    L Nobili
    Dept of Motor Sciences Center for Sleep Medicine, University of Genoa, Ospedale S Martino, Genova, Italy
    Clin Hemorheol Microcirc 22:21-7. 2000
    ..A relative morning hyperviscosity could be one of the leading mechanisms of cardiovascular morbidity which is actually known to be especially high in the morning hours...
  12. ncbi Exercise hemorheology as a three acts play with metabolic actors: is it of clinical relevance?
    Jean Frederic Brun
    Service Central de Physiologie Clinique, Centre d Exploration et de Réadaptation de Anomalies du Métabolisme Musculaire, CHU Lapeyronie, Montipellier, France
    Clin Hemorheol Microcirc 26:155-74. 2002
    ..Hemorheological measurements require to be studied, at least as sensitive markers of training, and possibly as "true" risk factors highly sensitive to exercise intensification...
  13. ncbi Microvascular blood viscosity in vivo and the endothelial surface layer
    A R Pries
    Charite Berlin, Dept of Physiology, Arnimallee 22, D 14195 Berlin, Germany
    Am J Physiol Heart Circ Physiol 289:H2657-64. 2005
    ..microvascular flow resistance as a function of vessel diameter and hematocrit in vivo; it combines in vitro blood viscosity with effects of a diameter-dependent ESL...
  14. ncbi Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence
    B Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, Victoria de Durango, Dgo, Mexico
    Clin Hemorheol Microcirc 44:75-85. 2010
    Decreasing blood viscosity has been proposed since the advent of hemodilution as a means for increasing perfusion in many pathological conditions, and increased plasma viscosity is associated with the presence of pathological conditions...
  15. ncbi Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosity
    S J Rim
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA, USA
    Circulation 104:2704-9. 2001
    ..We, therefore, hypothesized that abnormal coronary blood flow (CBF) reserve observed during hyperlipidemia is secondary to increased blood viscosity and not abnormal coronary vasomotion.
  16. ncbi Rheologic behavior of sickle and normal red blood cell mixtures in sickle plasma: implications for transfusion therapy
    Tamas Alexy
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Transfusion 46:912-8. 2006
    ..20-0.40), the proportion of SS RBCs (0-100%), and shear rate (1-1000/sec) for mixtures of oxygenated and deoxygenated SS and AA RBCs were evaluated in sickle plasma at 37 degrees C...
  17. ncbi Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 27:380-9. 2007
    ..systemic and microvascular conditions after volume restitution with plasma seems to be due to the decrease in blood viscosity. Conversely, the restoration of blood rheological properties improves resuscitation independently of the ..
  18. ncbi Haemorheology in exercise and training
    Mahmoud S El-Sayed
    Faculty of Science, School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, England
    Sports Med 35:649-70. 2005
    ..The acute increase in whole blood viscosity may unfavourably affect the microcirculatory blood flow and oxygen delivery to the tissues...
  19. ncbi In vitro effects of different medium molecular hydroxyethyl starch solutions and lactated Ringer's solution on coagulation using SONOCLOT
    C J Konrad
    Department of Anesthesiology and Intensive Care, Ruprecht Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany
    Anesth Analg 90:274-9. 2000
    ..000 seems preferable regarding some aspects of clot formation and retraction. RL affected clot formation only minimally, except for the early activation of clotting, which was measured by a shortened activated clotting time...
  20. ncbi Association between hematological parameters and high-density lipoprotein cholesterol
    Patrick M Moriarty
    Department of Internal Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Curr Opin Cardiol 20:318-23. 2005
    ..One mechanism by which high-density lipoprotein cholesterol protects the vascular system includes hemorheology, the study of blood flow...
  21. ncbi Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity
    Johannes Vogel
    Institute of Veterinary Physiology, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Blood 102:2278-84. 2003
    ..Although plasma viscosity did not differ between tg and wt mice, tg whole-blood viscosity increased to a lower degree (4-fold) than expected from corresponding hemoconcentrated wt blood (8-fold)...
  22. ncbi Interaction between inflammation and blood viscosity predicts cardiovascular mortality
    Per Torger Skretteberg
    Department of Cardiology, Oslo University Hospital, Ullevaal, Oslo, Norway
    Scand Cardiovasc J 44:107-12. 2010
    Inflammation and increased blood viscosity are associated with increased risk of cardiovascular mortality...
  23. ncbi Inter-species differences in hematocrit to blood viscosity ratio
    N Nemeth
    Department of Operative Techniques and Surgical Research, Institute of Surgery, Medical and Health Science Center, University of Debrecen, Hungary
    Biorheology 46:155-65. 2009
    Hematocrit (Hct) is the major determinant of whole blood viscosity and of its oxygen binding capacity: with increasing Hct, viscosity increases exponentially and oxygen capacity increases linearly...
  24. ncbi Gender differences in hemorheological parameters of coronary artery disease patients
    L Bogar
    Department of Anesthesiology and Intensive Care, University of Pecs, Hungary
    Clin Hemorheol Microcirc 35:99-103. 2006
    Plasma fibrinogen concentration, plasma and whole blood viscosity (WBV) are independent risk factors of coronary artery disease (CAD)...
  25. pmc Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy
    Jon Detterich
    Division of Cardiology, Children s Hospital Los Angeles, California 90027, USA
    Transfusion 53:297-305. 2013
    ..including percent hemoglobin (Hb)S, reticulocyte count, and circulating cell-free Hb, it increases blood viscosity, which reduces microvascular flow...
  26. ncbi Time course and mechanisms of mental stress-induced changes and their recovery: hematocrit, colloid osmotic pressure, whole blood viscosity, coagulation times, and hemodynamic activity
    Dolf de Boer
    Behavioural Medicine Group, School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
    Psychophysiology 44:639-49. 2007
    The mechanisms for stress-induced changes in hematocrit and blood viscosity are unclear. Twenty-two males completed experimental (30 min baseline, 10 min mental stress, 30 min recovery) and no-stress control conditions (70 min)...
  27. ncbi Both overall adiposity and abdominal adiposity increase blood viscosity by separate mechanisms
    Jean Frederic Brun
    Physiopathologie and Médecine Expérimentale du Coeur et des Muscles INSERM U1046, Unité d Explorations Métaboliques CERAMM, Service Central de Physiologie Clinique, Hopital Lapeyronie CHU Montpellier, France
    Clin Hemorheol Microcirc 48:257-63. 2011
    ..BMI and WHR are correlated to each other (r = 0.269; p = 0.009) and are both predictors of blood viscosity (BMI: r = 0.15516; p = 0.004; WHR: r = 0.3638; p = 0.03)...
  28. ncbi Reciprocal relationships between blood lactate and hemorheology in athletes: another hemorheologic paradox?
    Emmanuelle Varlet-Marie
    Laboratoire de Pharmacocinetique Clinique, Faculte de Pharmacie, Universite Montpellier I, France
    Clin Hemorheol Microcirc 30:331-7. 2004
    ..However, we have repeatedly observed that the rise in blood lactate during exercise is correlated to blood viscosity and red cell aggregation...
  29. ncbi Obstructive sleep apnea syndrome: blood viscosity, blood coagulation abnormalities, and early atherosclerosis
    Domenico Maurizio Toraldo
    Third Division, A Galateo Lung Disease Hospital, ASL Lecce, via a c Casetti n 2, 73100, Lecce, Italy
    Lung 191:1-7. 2013
    ..Recent investigations of atherosclerosis in OSAS have focused on thrombotic tendency and blood viscosity, providing new insight into mechanisms of the disease...
  30. pmc Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia
    Yann Lamarre
    Institut National de la Santé et de la Recherche Médicale UMR 665, Hôpital RICOU, Centre Hospitalier Universitaire de Pointe à Pitre, Pointe a Pitre, Guadeloupe
    PLoS ONE 8:e66004. 2013
    ..We compared the hematological, lipid and hemolytic profiles, as well as blood viscosity, between SCA patients with normal BP (<120/70 mmHg, n = 54) and those with relative hypertension (BP≥..
  31. ncbi Effect of hematocrit on blood pressure via hyperviscosity
    Y Cinar
    Haydarpasa Numune Hospital, Istanbul, Turkey
    Am J Hypertens 12:739-43. 1999
    Increase in blood viscosity, defined as resistance to flow, is one factor in hypertension and atherosclerosis that contributes to the morbidity and mortality associated with tissue ischemia...
  32. ncbi Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus
    Stephanie Booth
    University of Chicago, Chicago, Illinois 60637, USA
    Arthritis Rheum 57:845-50. 2007
    To determine if whole blood viscosity (WBV), a rheologic variable contributing to risk of myocardial infarction and stroke in the general population, is elevated in patients with systemic lupus erythematosus (SLE), particularly SLE ..
  33. ncbi Gender- and age-related variations in blood viscosity in normal volunteers: a study of the effects of extract of Allium sativum and Ginkgo biloba
    J C F Galduróz
    Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Brazil
    Phytomedicine 14:447-51. 2007
    This study sought to compare the effects of age and gender on blood viscosity and to appraise the effectiveness of Ginkgo biloba and Allium sativum extracts in reducing blood viscosity...
  34. ncbi Whole blood viscosity and microvascular abnormalities in Alzheimer's Disease
    M Meighan Smith
    Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Clin Hemorheol Microcirc 41:229-39. 2009
    ..that abnormalities in hemorheologic parameters, including vessel diameter, flow velocity, and whole blood viscosity (WBV), would be present in Alzheimer's Disease (AD) and would correlate with microvascular abnormalities (..
  35. ncbi Oxygen delivery index in subjects with normal haemoglobin (HbAA), sickle cell trait (HbAS) and homozygous sickle cell disease (HbSS)
    A S Bowers
    Department of Basic Medical Sciences, Physiology Section, Faculty of Medical Sciences, University of the West Indies, Jamaica, West Indies
    Clin Hemorheol Microcirc 40:303-9. 2008
    ..Whole blood viscosity was measured at low and high shear rates of 23 s(-1) and 230 s(-1), respectively, using a Wells Brookfield ..
  36. ncbi Hemorheology and hypertension: not "chicken or egg" but two chickens from similar eggs
    L Bogar
    Department of Anesthesia and Intensive Therapy, University of Pecs, Hungary
    Clin Hemorheol Microcirc 26:81-3. 2002
    ..demonstrated significant positive correlation between the severity of arterial hypertension (AHT) and whole blood viscosity. Red blood cell aggregation has also been associated with AHT especially in the severe form of the disease...
  37. ncbi The influence of flow, vessel diameter, and non-newtonian blood viscosity on the wall shear stress in a carotid bifurcation model for unsteady flow
    Frieke M A Box
    Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Invest Radiol 40:277-94. 2005
    ..We investigated the effects of non-Newtonian blood viscosity, variations in flow rate, and vessel diameter on wall phenomena in a carotid bifurcation model.
  38. ncbi Blood viscosity changes in experimentally Trypanosoma cruzi-infected rats
    H H Berra
    Cátedra Fisiología Humana, Departamento de Ciencias Fisiologicas, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina
    Clin Hemorheol Microcirc 32:175-82. 2005
    ..We studied whole blood viscosity (eta(b)) and plasmatic and cellular factors influencing it in rats, 7 and 14 days after experimental ..
  39. ncbi Free oscillation rheometry detects changes in clot properties in pregnancy and thrombocytopenia
    Nahreen Tynngård
    Department of Clinical Immunology and Transfusion Medicine, University Hospital, Linkoping, Sweden
    Platelets 19:373-8. 2008
    ..The results suggest that FOR can provide new information on the haemostatic status of patients at risk of thrombotic or bleeding events as well as information on the haemostatic effect of a platelet transfusion...
  40. ncbi Influence of contrast media (iopromide, ioxaglate, gadolinium-DOTA) on blood viscosity, erythrocyte morphology and platelet function
    Walter H Reinhart
    Department of Internal Medicine, Kantonsspital, CH 7000 Chur, Switzerland
    Clin Hemorheol Microcirc 32:227-39. 2005
    The influence of contrast media on blood viscosity, erythrocyte morphology and platelet function was studied. In vitro blood was incubated with iopromide (Ultravist), ioxaglate (Hexabrix) or gadolinium-DOTA (Dotarem)...
  41. pmc Blood viscosity and the expression of inflammatory and adhesion markers in homozygous sickle cell disease subjects with chronic leg ulcers
    Andre S Bowers
    Department of Basic Medical Sciences, Physiology Section, University of the West Indies, Mona, Kingston 7, Jamaica
    PLoS ONE 8:e68929. 2013
    To determine differences in TNF-α, IL-1β, IL-10, sICAM-1 concentrations, leg hypoxia and whole blood viscosity (WBV) at shear rates of 46 sec(-1) and 230 sec(-1) in persons with homozygous S sickle cell disease (SCD) with and without ..
  42. ncbi Whole blood viscosity, plasma viscosity and erythrocyte aggregation in nine mammalian species: reference values and comparison of data
    U Windberger
    Institute for Biomedical Research, University of Vienna, Währingergürtel 18 20, Austria
    Exp Physiol 88:431-40. 2003
    In this study species-specific values for whole blood viscosity (WBV), plasma viscosity (PV) and erythrocyte aggregation (EA) were determined in a total of 360 animals...
  43. ncbi Role of plasma proteins in whole blood viscosity: a brief clinical review
    Hau C Kwaan
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Clin Hemorheol Microcirc 44:167-76. 2010
    Whole blood viscosity is affected by a number of factors, among which plasma proteins are a major component. They exert their effects either directly or through their influence on red cell aggregation...
  44. ncbi Blood viscosity and elevated carotid intima-media thickness in men and women: the Edinburgh Artery Study
    A J Lee
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Edinburgh University Medical School, UK
    Circulation 97:1467-73. 1998
    ..We therefore studied the relationship between these factors and carotid intima-media thickness (IMT)...
  45. ncbi Lack of association between systolic blood pressure and blood viscosity in normotensive healthy subjects
    Concetta Irace
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Magna Græcia University, Catanzaro, Italy
    Clin Hemorheol Microcirc 51:35-41. 2012
    ..To better understand the relationship between these two variables, we evaluated blood viscosity and blood pressure in a group of healthy subjects without cardiovascular risk factors.
  46. ncbi Blood viscosity and hemodynamics during exercise
    Philippe Connes
    Laboratoire ACTES, Departement de Physiologie, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe, France
    Clin Hemorheol Microcirc 51:101-9. 2012
    We tested the effects of submaximal exercise on blood viscosity (η(b)), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated...
  47. ncbi Oxygen delivery index in homozygous sickle cell disease: steady and crisis states
    A S Bowers
    Department of Basic Medical Sciences, Physiology Section, University of the West Indies, Mona Campus, Kingston 7, Jamaica, West Indies
    Br J Biomed Sci 66:148-9. 2009
    ..Whole blood viscosity was measured with a Wells Brookfield viscometer at a shear rate of 230 sec(-1) and haematocrit was measured ..
  48. ncbi Blood viscosity and hematological changes during prolonged submergence in normoxic water of northern and southern musk turtles (Sternotherus odoratus)
    D K Saunders
    Division of Biological Sciences, Emporia State University, Kansas 66801, USA
    J Exp Zool 287:459-66. 2000
    ..We investigated the effects of submergence in normoxic water at 3 degreesC on the blood viscosity of musk turtles from northern (Massachusetts) and southern (Alabama) locales...
  49. ncbi High blood viscosity is closely associated with cigarette smoking and markedly reduced by smoking cessation
    Sayaka Shimada
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
    Circ J 75:185-9. 2011
    ..The rheological properties of blood assessed by the microchannel method reflect the blood's viscosity and the state of microthrombus formation, which may predict cardiovascular thrombotic events...
  50. ncbi Hemorheologic alterations in hypertension: chicken or egg?
    H J Meiselman
    Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles 90033, USA
    Clin Hemorheol Microcirc 21:195-200. 1999
    ....
  51. pmc Blood pressure and blood viscosity are not correlated in normal healthy subjects
    Beatriz Y Salazar Vázquez
    Departamento de Medicina Experimental, Universidad Nacional Autonoma de Mexico, Hospital General de Mexico, Mexico DF, Mexico
    Vasc Health Risk Manag 8:1-6. 2012
    The relationship between blood viscosity, hematocrit (Hct), and mean arterial blood pressure (MAP) was studied in a healthy population of 91 men and 66 women with an average age of 30.6 ± 8...
  52. ncbi Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 291:H581-90. 2006
    ..Thus the fall in systemic and microvascular conditions during extreme hemodilution with low-viscosity plasma expanders seems to be, in part, from the decrease in blood viscosity independent of the reduction in oxygen content.
  53. ncbi Relationship between hemorheological factors and insulin sensitivity in normotensive and hypertensive premenopausal women
    G Nordby
    Department of Internal Medicine, Ullevaal Hospital, University of Oslo, Norway
    Am J Hypertens 8:439-44. 1995
    ..study aimed at testing a possible relationship between hemorheologic factors such as hematocrit and whole blood viscosity, and insulin sensitivity in premenopausal, hypertensive (HT), and normotensive (NT) women...
  54. ncbi Effects of 6-h exposure to low relative humidity and low air pressure on body fluid loss and blood viscosity
    N Hashiguchi
    Department of Health Science, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Indoor Air 23:430-6. 2013
    ..relative humidity (RH) and low air pressure in a simulated air cabin environment on body fluid loss (BFL) and blood viscosity. Fourteen young healthy male subjects were exposed to four conditions, which combined RH (10% RH or 60% RH) ..
  55. ncbi Modulation of red blood cell aggregation and blood viscosity by the covalent attachment of Pluronic copolymers
    J K Armstrong
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biorheology 38:239-47. 2001
    ..property of Pluronics has been utilized to enhance or inhibit RBC aggregation and hence to vary low-shear blood viscosity. Pluronic-coated RBCs were prepared using reactive DT derivatives of a range of Pluronics (F68, F88, F98 and ..
  56. ncbi Cerebrospinal fluid viscosity: a novel diagnostic measure for acute meningitis
    Funda Yetkin
    Department of Infectious Disease, Inonu University School of Medicine, Malatya, Turkey
    South Med J 103:892-5. 2010
    ..It has been previously reported that plasma viscosity can be used as an inflammatory marker. In this study we aimed to evaluate the role of CSF viscosity as a complementary measure for diagnosis of meningitis in suspected patients...
  57. ncbi High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Biorheology 38:229-37. 2001
    ..studies lead to the axiom that high plasma viscosity is detrimental and that it is beneficial to lower blood viscosity, a precept embodied in the practice of hemodilution, where improved perfusion is attributed to the lowering ..
  58. ncbi Molecular biology and self-regulatory mechanisms of blood viscosity: a review
    W H Reinhart
    Department of Internal Medicine, Kantonsspital, Chur, Switzerland
    Biorheology 38:203-12. 2001
    b>Blood viscosity is determined by plasma viscosity, hematocrit, erythrocyte deformability and aggregation. Plasma viscosity and hematocrit are directly regulated by the organism...
  59. ncbi Hemorheological changes and overproduction of cytokines from immune cells in mild to moderate dementia of the Alzheimer's type: adverse effects on cerebromicrovascular system
    S B Solerte
    Department of Internal Medicine, Geriatrics and Gerontology Clinic, School of Geriatrics, University of Pavia, Ospedale S Margherita, Piazza Borromeo 2, 27100, Pavia, Italy
    Neurobiol Aging 21:271-81. 2000
    ....
  60. ncbi Changes of blood viscosity in patients treated with 5-fluorouracil--a link to cardiotoxicity?
    M Cwikiel
    Department of Oncology, University Hospital Lund, Sweden
    Acta Oncol 34:83-5. 1995
    ..The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients...
  61. ncbi The influence of lipoproteins on whole-blood viscosity at multiple shear rates
    Arnold Slyper
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Metabolism 54:764-8. 2005
    Whole-blood viscosity appears to be an independent predictor of stroke, carotid intima-media thickening, and carotid atherosclerosis...
  62. ncbi Treatment with aspirin and dipyridamole is more effective than aspirin in reducing low shear blood viscosity
    Robert S Rosenson
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48106, USA
    Microcirculation 15:615-20. 2008
    Investigate effects of aspirin/dipyridamole and aspirin on blood viscosity (BV) in subjects with hyperhomocystememia (>14 micromol/L) and stable cardiovascular disease (CVD) or >or= 20% risk for CVD were the aims of this study.
  63. ncbi Effects of oral acrylamide intake on blood viscosity parameters in rats
    Okan Arihan
    Faculty of Medicine, Department of Physiology, Hacettepe University, Ankara, Turkey
    Clin Hemorheol Microcirc 47:45-52. 2011
    ..of chronic administration of acrylamide at a dose which does not induce neurotoxicity were evaluated on blood viscosity parameters (hematocrit, erythrocyte deformability, erythrocyte aggregation and plasma viscosity)...
  64. ncbi Effect of immunoglobulin therapy on blood viscosity and potential concerns of thromboembolism, especially in patients with acute Kawasaki disease
    Reizo Baba
    Department of Paediatrics, Aichi Medical University School of Medicine, Aichi Gun, Aichi, Japan
    Recent Pat Cardiovasc Drug Discov 3:141-4. 2008
    ..High levels of IgG, immune complex formation, and increased platelet aggregation could increase blood viscosity after IVIG infusion...
  65. ncbi Improved treatment of sudden hearing loss by specific fibrinogen aphaeresis
    Heidrun Ullrich
    Institute of Transfusion Medicine, University of Hamburg, Hamburg, Germany
    J Clin Apher 19:71-8. 2004
    ..Clin. Immunol. Immunopath. 68:41-45, 1993; Gussen, Ann. Otol. Rhinol. Laryngol. 85:94-100, 1976]. Elevated blood viscosity due to high fibrinogen levels is supposed to cause decreased cochlear blood flow and thus initiate sudden ..
  66. ncbi Does carbonyl stress cause increased blood viscosity during storage?
    Guolin Li
    The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    Clin Hemorheol Microcirc 44:145-54. 2010
    ..However, the biochemical mechanisms are only partly understood...
  67. ncbi Prognostic impact of low-shear whole blood viscosity in hypertensive men
    G Ciuffetti
    Unit of Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, 06156 Perugia, Italy
    Eur J Clin Invest 35:93-8. 2005
    The role of blood viscosity as a marker for discriminating cardiovascular risk in essential hypertension remains uncertain...
  68. ncbi Hyperviscosity syndrome in plasma cell dyscrasias
    Jayesh Mehta
    The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    Semin Thromb Hemost 29:467-71. 2003
    ..Immediate therapy of symptomatic hyperviscosity is directed at reduction of blood viscosity by plasmapheresis to control symptoms...
  69. ncbi Physical activity, cardiorespiratory fitness, and the primary components of blood viscosity
    S Carroll
    School of Leisure and Sports Studies, Leeds Metropolitan University, Beckett Park Campus, United Kingdom
    Med Sci Sports Exerc 32:353-8. 2000
    ....
  70. pmc Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Resuscitation 75:124-34. 2007
    ....
  71. ncbi Is hemoglobin desaturation related to blood viscosity in athletes during exercise?
    P Connes
    UPRES EA 2991 Sport, Performance et Santé, Montpellier, France
    Int J Sports Med 25:569-74. 2004
    ..b>Blood viscosity may be implicated in exercise-induced pulmonary hemorrhage in race horses...
  72. ncbi Reduction of red blood cell disaggregability during submaximal exercise: relationship with fibrinogen levels
    E Varlet-Marie
    Laboratoire de Pharmacocinetique Clinique, Faculte de Pharmacie, Universite Montpellier I, France
    Clin Hemorheol Microcirc 28:139-49. 2003
    ..High shear rate viscometry (1000 s(-1) evidenced an increase in blood viscosity explained by an increase in hematocrit (+8% p<0.01) and plasma viscosity (+7% p<0.01)...
  73. ncbi Pleiotropic effects of LDL apheresis
    Alfonso Ramunni
    Division of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy
    Atheroscler Suppl 10:53-5. 2009
    ..Besides these actions, LA improves whole blood viscosity and endothelium-mediated vasodilation, and has a positive effect on the hemorheological picture, improving ..
  74. ncbi Association among low whole blood viscosity, haematocrit, haemoglobin and diabetic retinopathy in subjects with type 2 diabetes
    C Irace
    Department of Clinical and Experimental Medicine G Salvatore, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Br J Ophthalmol 95:94-8. 2011
    ..Clinical studies have described an association among blood viscosity, haematocrit, haemoglobin and macro-angiopathy...
  75. ncbi Platelet aggregation, blood viscosity and serum lipids in hypertensive and obese children
    Ibolya Haszon
    Department of Paediatrics, University of Szeged, Koranyi fasor 14 15, Hungary
    Eur J Pediatr 162:385-90. 2003
    ..Multivariate analysis revealed significant interactions in the effects of obesity and hypertension on platelet aggregation and thiol oxidation...
  76. ncbi Acidosis induced by lactate, pyruvate, or HCl increases blood viscosity
    Walter H Reinhart
    Department of Internal Medicine, Kantonsspital, Chur, Switzerland
    J Crit Care 17:68-73. 2002
    ..It is not clear if lactate is only a marker or a mediator of disease. We tested the hypothesis that acidosis induced by lactate and pyruvate affects blood flow properties...
  77. ncbi Temporal effect of Guanxin No. 2 on cardiac function, blood viscosity and angiogenesis in rats after long-term occlusion of the left anterior descending coronary artery
    Xiaowei Zeng
    College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, PR China
    J Ethnopharmacol 118:485-94. 2008
    ..2 decoction (GX II) on cardiac dysfunction combined with the blood viscosity and myocardial hypertrophy parameters in myocardial infarction (MI) rats.
  78. ncbi Reducing blood viscosity with magnetic fields
    R Tao
    Department of Physics, Temple University, Philadelphia, Pennsylvania 19122, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 84:011905. 2011
    b>Blood viscosity is a major factor in heart disease. When blood viscosity increases, it damages blood vessels and increases the risk of heart attacks...
  79. pmc Hematocrit and mean arterial blood pressure in pre- and postmenopause women
    Beatriz Y Salazar Vázquez
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037 0412, USA
    Vasc Health Risk Manag 5:483-8. 2009
    ..in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in ..
  80. ncbi Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals
    Beatriz Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, Durango, Dgo, Mexico
    Clin Hemorheol Microcirc 44:55-61. 2010
    To determine the relationship between mean arterial blood pressure (MAP) and blood viscosity in diabetic type 1 children and healthy controls to investigate whether MAP is independent of blood viscosity in healthy children, and vice versa.
  81. ncbi Effect of n-tyrosol on blood viscosity and platelet aggregation
    M B Plotnikov
    Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk
    Bull Exp Biol Med 143:61-3. 2007
    Experiments on rats showed that n-tyrosol limited the increase in blood viscosity during thermal exposure at a shear rate of 5-300 sec(-1) and inhibited ADP-induced platelet aggregation...
  82. ncbi Blood viscosity, hemodynamics and vascular hindrance in a rat model of acute controlled bleeding and volume restitution with blood or Haemaccel
    N Hilzenrat
    Gastroenterology Division, The Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Acta Anaesthesiol Scand 45:371-6. 2001
    Hemorrhage and volume restitution with commercially available solutions is followed by reduced blood viscosity. Consequent hemodynamic changes may arise not only from the reduced viscosity itself but also from changes in vascular ..
  83. ncbi Cognitive performance, SPECT, and blood viscosity in elderly non-demented people using Ginkgo biloba
    R F Santos
    Department of Psychobiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Brazil
    Pharmacopsychiatry 36:127-33. 2003
    ..possible number of functions including Single Photon Emission Computer Tomography (SPECT) and measures of blood viscosity. The study was run on a double-blind basis with placebo and Ginkgo biloba groups evaluated over a period of 8 ..
  84. ncbi Model-independent relationships between hematocrit, blood viscosity, and yield stress derived from Couette viscometry data
    Y Leong Yeow
    Department of Chemical Engineering, The University of Melbourne, Melbourne, Victoria, Australia
    Biotechnol Prog 18:1068-75. 2002
    ....
  85. ncbi Low hematocrit per blood viscosity ratio as a mortality risk factor in coronary heart disease
    P Kenyeres
    1st Department of Medicine, University of Pecs, Hungary
    Clin Hemorheol Microcirc 38:51-6. 2008
    Increased blood viscosity has not been associated with mortality risk in coronary heart disease (CHD)...
  86. pmc Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution
    David S Long
    Department of Mechanical and Industrial Engineering, University of Illinois at Urbana Champaign, Urbana, 61801, USA
    Proc Natl Acad Sci U S A 101:10060-5. 2004
    ..Radial distributions in blood viscosity, shear stress, and shear rate are obtained and used to predict axial pressure gradient, apparent viscosity, ..
  87. ncbi Cardiovascular risks of anemia correction with erythrocyte stimulating agents: should blood viscosity be monitored for risk assessment?
    Seul Ki Jeong
    Department of Neurology and Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, South Korea
    Cardiovasc Drugs Ther 24:151-60. 2010
    ..risk of CVD among certain patients treated with ESAs and suggests a risk management approach based on blood viscosity. Whole blood viscosity is a key determinant of the work of the heart, and elevated blood viscosity appears to ..
  88. ncbi Blood viscosity: effects of mental stress and relations to autonomic nervous system function and insulin sensitivity
    Henrik M Reims
    Department of Cardiology, University of Michigan, Ann Arbor, MI, USA
    Blood Press 14:159-69. 2005
    We studied effects of mental stress on whole-blood viscosity (WBV) and blood pressure (BP), and relations between WBV and autonomic nervous system activity and insulin sensitivity...
  89. ncbi White blood cell and platelet counts could affect whole blood viscosity
    Chao Hung Ho
    Division of Hematology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:394-7. 2004
    b>Blood viscosity is correlated with cerebral blood flow and cardiac output, and increased viscosity may increase the risk of thrombosis or thromboembolic events...
  90. ncbi Reduced cerebral blood flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic mice with excessive erythrocytosis
    Thomas Frietsch
    Department of Anesthesiology and Critical Care Medicine, Faculty of Clinical Medicine Mannheim, Mannheim, Germany
    J Cereb Blood Flow Metab 27:469-76. 2007
    ..Hemodilution suggests that high blood viscosity is a cause of the decrease in CBF and partly of the increase in CMR(glc)...
  91. ncbi Effects of high and low inspired fractions of oxygen on horse erythrocyte membrane properties, blood viscosity and muscle oxygenation during anaesthesia
    Karine Portier
    Ecole Nationale Veterinaire de Lyon, Equine Department, Universite de Lyon, Lyon, France
    Vet Anaesth Analg 36:287-98. 2009
    ..To evaluate whether a period of hyperoxia or after a period of hypoxia produced changes attributable to reactive oxygen species in anaesthetized horses...
  92. ncbi The influence of priming solutions used in cardiopulmonary bypass on blood viscosity in hypothermic conditions
    Sinasi Manduz
    Cumhuriyet University, Cardiovascular Surgery, Sivas, Turkey
    ASAIO J 54:275-7. 2008
    ..This study aimed to demonstrate the alteration of blood viscosity following dilution with priming solutions: hydroxyethyl starch (HES), gelatin, albumin, and Ringer's lactated ..
  93. pmc The variability of blood pressure due to small changes of hematocrit
    Beatriz Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, Victoria de Durango, Durango, Mexico
    Am J Physiol Heart Circ Physiol 299:H863-7. 2010
    ..by isovolemic hemodilution using hamster plasma to determine the acute effect of small changes in Hct and blood viscosity on systemic hemodynamics...
  94. ncbi Opposite effects of low-density and high-density lipoprotein on blood viscosity in fasting subjects
    G D Sloop
    Department of Pathology, Louisiana State University Medical Center in New Orleans, 70112, USA
    Clin Hemorheol Microcirc 19:197-203. 1998
    Given the enlarging body of evidence implicating increased blood viscosity in atherogenesis, the authors hypothesize that lipoproteins modulate the atherogenic process by affecting blood viscosity...
  95. ncbi Effects of a moderate-intensity aerobic program on blood viscosity, platelet aggregation and fibrinolytic balance in young and middle-aged sedentary subjects
    Ludovico Coppola
    Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Policlinico Universitario, Naples, Italy
    Blood Coagul Fibrinolysis 15:31-7. 2004
    ..that moderate-intensity aerobic training improves fibrinolytic activity and reduces platelet aggregation and blood viscosity. In 15 young (11 males and four females; age, 24-32 years) and 15 middle-aged (11 males and four females; age,..
  96. ncbi Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model
    Judith Martini
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 291:H310-7. 2006
    ..We conclude that a minimum viscosity level is necessary for generating the shear stress required for maintaining normal cardiovascular function...
  97. pmc Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus: the atherosclerosis risk in communities (ARIC) study
    Leonardo J Tamariz
    Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
    Am J Epidemiol 168:1153-60. 2008
    Several lines of evidence support the notion that elevated blood viscosity may predispose to insulin resistance and type 2 diabetes mellitus by limiting delivery of glucose, insulin, and oxygen to metabolically active tissues...
  98. ncbi Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion
    Amy G Tsai
    Dept of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1730-9. 2005
    ..between perivascular NO concentration and the locally calculated shear stress induced by the procedures, when blood viscosity was corrected according to Hct values previously determined in studies of microvascular Hct distribution...
  99. ncbi Effect of hemodialysis on whole blood viscosity
    S Vaisman
    Pottstown Medical Specialists, Inc, Phoenixville, PA, USA
    Int J Artif Organs 32:329-35. 2009
    ..The purpose of the present study was to examine the effect of hemodialysis procedures on the hemoconcentration status of end-stage renal disease (ESRD) patients...
  100. ncbi Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity
    Eszter Pais
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Clin Hemorheol Microcirc 35:139-42. 2006
    ..hemorheological parameters and thus we have begun to assess the effects of the enzyme on RBC aggregation and blood viscosity. Blood samples were incubated with nattokinase (final activities of 0, 15.6, 31.3, 62...
  101. ncbi Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene
    Maia Mantskava
    Microcirculation Research Center, I Beritashvili Institute of Physiology, 14 Gotua St, 0160 Tbilisi, Georgia
    Clin Hemorheol Microcirc 35:307-10. 2006
    ..The disturbed blood fluidity related to the increased RBC aggregability in the microcirculation promotes, in particular, the development of legs gangrene in both types of diabetes mellitus...

Research Grants48

  1. Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular Reactivity
    Deidre Wipke Tevis; Fiscal Year: 2009
    ..Preliminary data in healthy men suggest that hematocrit (Hct, a determinant of blood viscosity) peaks while plasma nitrite/nitrate (NOx, a stable metabolite of the vasodilator molecule, nitric oxide) ..
  2. Impact of Blood Viscosity on Oxygen Delivery in humans with Sickle Cell Anemia
    THOMAS DUANE COATES; Fiscal Year: 2011
    ..The pathophysiology of SCD is due in part to the increase in blood viscosity caused by hemoglobin S (HbS)...
  3. Cytotoxic Heat Transfer and Thrombotic Risk in Microwave Tumor Ablation
    CHIH SHENG J CHIANG; Fiscal Year: 2013
    ..of this project will lead to better understanding of coupling electromagnetic analysis with thermal flow, blood viscosity changes in a high-temperature environment and endothelial damage near microwave ablation zones...
  4. POLYMER-COATED RED BLOOD CELL FOR SICKLE CELL DISEASE
    TIMOTHY FISHER; Fiscal Year: 2003
    ..interactions, such as RBC aggregation, are minimized; the latter effect results in greatly reduced low-shear blood viscosity even when the hematocrit of SS blood is increased with coated RBC...
  5. Resuscitating Blood-Substituted Hypothermic Dogs
    Hal Sternberg; Fiscal Year: 2005
    ..Sludging of blood in the microvasculature (hypothermia increases blood viscosity) causes blockage of the microvasculature of the major organs during the period of circulatory arrest...
  6. ERYTHROPOIETIC AND HEMODYNAMIC RESPONSE TO HYPOXEMIA
    John Widness; Fiscal Year: 1990
    ..in erythropoietic (Ep, Hb, reticulocytes, and red cell mass), hemodynamic (blood pressure, heart rate, whole blood viscosity, and regional blood flow), and growth parameters (organ and body weights, and length measurements) will be ..
  7. EVALUATION OF DIAGNOSTIC CLINICAL HEMORRHEOLOGY
    GEOFFREY SEAMAN; Fiscal Year: 1980
    The program is evaluating blood viscosity associated variables (apparent blood viscosity at various rates of shear, hematocrit, red cell deformability, fluidity and size, degree of cellular aggregation, plasma viscosity, serum protein ..
  8. DIVERGENCE OF BLOOD PRESSURE BY RACE IN ADOLESCENT GIRLS
    Stephen Daniels; Fiscal Year: 2000
    ..blood volume (left ventricular end-diastolic volume), heart rate, left ventricular contractility, whole blood viscosity, and left ventricular mass and geometry will be measured...
  9. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..Mechanisms we will study include changes in blood viscosity, peak oxygen consumption (VO2), calf blood flow, brachial artery endothelial reactivity, and inflammatory ..
  10. ULTRASONIC BLOOD VISCOMETER
    Craig Hartley; Fiscal Year: 2001
    DESCRIPTION (Verbatim from Applicant's Abstract): Blood viscosity is altered in diseases such as sickle cell anemia, hypertension, and atherosclerosis and also during coagulation, but its measurement requires complex and expensive ..
  11. IN VIVO MEASUREMENT OF WALL SHEAR STRESS IN THE AORTA
    Gerald Miller; Fiscal Year: 1980
    ..This information can aid in monitoring flush conditions between the hot film probe and aortic wall. Blood viscosity is computed from blood hematocrit measurements...
  12. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2004
    ..is that when a blood replacement fluid is introduced in the circulation it should cause the resulting blood viscosity to remain sufficiently elevated to insure the adequate generation of shear stress at the-blood/tissue ..
  13. DISPOSABLE BLOOD VISCOMETER
    NOH PARK; Fiscal Year: 1992
    b>Blood viscosity can be a powerful diagnostic tool for early detections of cancer, heart disease, peripheral arterial disease, abnormal hemoglobin, or some immunological disorders...
  14. ANTILIPEMIC REGIMES IN PERIPHERAL ARTERIOSCLEROSIS
    JAY COFFMAN; Fiscal Year: 1980
    ..whether correction of lipoprotein abnormalities has a beneficial effect on the circulatory impairment in these patients, either by halting or reversing the arteriosclerotic process in the blood vessels or by a change in blood viscosity.
  15. Cellular imaging of blood flow rheological disorders
    Guy Cloutier; Fiscal Year: 2007
    ..Among them may be cited its effect on the formation of sludge blood in microvessels, increased blood viscosity, occurrence of vascular thrombosis, and increased flow resistance...
  16. Phase 3 stem cell transplant for light chain amyloidosis
    Morie A Gertz; Fiscal Year: 2011
    ..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
  17. NOVEL SEROTHERAPY STRATEGIES--PLASMA CELL MALIGNANCIES
    STEVEN TREON; Fiscal Year: 2004
    ..Analogous to our work with Muc-1, we will also attempt to identify other PCD selective targets by generating and examining mAbs specific to the plasma cell glycoform of CD138. ..
  18. HEMORHEOLOGY STUDIES RELATED TO IN VIVO BLOOD FLOW
    HERBERT MEISELMAN; Fiscal Year: 2008
    ....
  19. CNS transcription modulation in peripheral inflammation
    Ma Li Wong; Fiscal Year: 2002
    ..The proposed studies will result in new data that will be needed for us to generate novel testable hypotheses, which will provide the framework for future R0l applications. ..
  20. Dose-finding, pharmacokinetic, safety and efficacy of bivalirudin in children
    Guy Young; Fiscal Year: 2009
    ..More modern therapies are available but have not been systematically tested in children. This study will determine whether one such medication, bivalirudin is a safer and more effective alterative. ..
  21. CORONARY MICROCIRCULATION-ACUTE MYOCARDIAL INFARCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The study aims will be to test the 4 above-mentioned hypotheses in patients with suspected AMI. ..
  22. Behavioral state development in infants
    Mark Blumberg; Fiscal Year: 2009
    ..abstract_text> ..
  23. Induction of Tissue Factor by Patient Sera in HUS
    Eric Grabowski; Fiscal Year: 2007
    ..A key additional feature of this proposal is the use of our newly formed collaborative group of pediatric nephrologists to facilitate patient recruitment [unreadable] [unreadable]..
  24. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
    ..abstract_text> ..
  25. FONDAPARINUM IN CHILDREN WITH THROMBOSIS
    Guy Young; Fiscal Year: 2007
    ..Pharmacokinetic analyses as well as safety and efficacy determinations will be made which will provide valuable information on this new anticoagulant for pediatric patients. [unreadable] [unreadable]..
  26. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2008
    ..valves that improves upon the shortcomings of existing replacement valves, reduces the cost burden on the health care system and improves the survival rate of patients with heart valve prostheses [unreadable] [unreadable] [unreadable]..
  27. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..4. Whether changes in blood viscosity affect coronary blood flow reserve...
  28. Ultrafine Particle Exposure in Humans
    Mark Frampton; Fiscal Year: 2005
    ..These studies will identify key mechanisms for the cardiovascular effects of exposure to ambient air particles. ..
  29. TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERS
    Marcos Intaglietta; Fiscal Year: 2009
    ..Conventional plasma expanders (PEs) lower blood viscosity and their use beyond the transfusion trigger causes: 1) Arteriolar vasoconstriction and decreased blood flow;..
  30. Activation of clotting & cell adhesion: gas embolism
    David M Eckmann; Fiscal Year: 2010
    ..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
  31. CARDIOVASCULAR CONCOMITANTS OF ULTRASONIC VOCALIZATIONS
    Mark Blumberg; Fiscal Year: 2002
    ..Through these approaches, an integrated view of the varied mechanisms by which infant and adult mammals regulate cardiovascular function during physiological and behavioral challenges will emerge. ..
  32. MAGNETIC RESONANCE CORONARY ANGIOGRAPHY
    John Oshinski; Fiscal Year: 2001
    ....
  33. CHRONIC ISCHEMIC LEFT VENTRICULAR DYSFUNCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The drug we will test is carvedilol because of its unique adrenergic inhibitor properties as well as its anti-oxidant and anti-apoptotic properties. ..
  34. BLys inhibition using TACI-Fc in patients with B-bell non-Hodgkins' Lymphoma
    Stephen Ansell; Fiscal Year: 2008
    ..abstract_text> ..
  35. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  36. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..4. Whether changes in blood viscosity affect coronary blood flow reserve...
  37. Nonlinear Dynamics in Microvascular Networks
    Russell Carr; Fiscal Year: 2004
    ..Oscillating flows and pressures due to nonlinear effects will also have an impact on mass transfer calculations from blood to surrounding tissues. Time varying flows are also implicated in the health of the vessel wall. ..
  38. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  39. Relationship of Hematocrit to Ischemic Stroke Outcome
    Paul Diamond; Fiscal Year: 2006
    ..HCT is the main determinant of blood oxygen carrying capacity and blood viscosity. Central Nervous System (CNS) oxygen transport diminishes at high HCT levels due to increased blood viscosity ..
  40. Depression/Metabolic Syndrome in Mexican-American Women.
    Ma Li Wong; Fiscal Year: 2006
    ..This work will address this important area by the study of an population group who is markedly under represented in patient-oriented investigation. [unreadable] [unreadable]..
  41. Pharmacogenetics of Antidepressant Drugs
    Ma Li Wong; Fiscal Year: 2007
    ..This K-24 award will make possible for the P.I. to significantly increase her time allocation for patient-oriented research and for mentoring of junior trainees and fellows in clinical research. [unreadable] [unreadable]..
  42. Ultrafine Particle-Induced Oxidative Stress
    Mark Frampton; Fiscal Year: 2007
    ..abstract_text> ..
  43. Functional Tissue Factor on Activated Endothelium
    Eric Grabowski; Fiscal Year: 2004
    ....
  44. FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    Marcos Intaglietta; Fiscal Year: 2004
    ..It is proposed that blood viscosity is a determinant of p02 distribution in the microcirculation because: 1) Viscosity is a factor in determining ..
  45. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2009
    ..reductions in flow and duration of ischemia, and compared to reductions in shear stress incurred by reducing blood viscosity using hemodilution...