Genomes and Genes
Summary: The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Publications252 found, 100 shown here
- Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C diseaseJulien Tripette
Laboratoire ACTES, EA 3596, Departement de Physiologie, Universite des Antilles et de la Guyane, Campus de Fouillole, Pointe a Pitre, Guadeloupe, French West Indies
Haematologica 94:1060-5. 2009Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation...
- Blood rheology and hemodynamicsOguz K Baskurt
Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
Semin Thromb Hemost 29:435-50. 2003..Impairment of blood fluidity may significantly affect tissue perfusion and result in functional deteriorations, especially if disease processes also disturb vascular properties...
- Erythrocyte aggregation: basic aspects and clinical importanceOguz K Baskurt
Koc University School of Medicine, Istanbul, Turkey
Clin Hemorheol Microcirc 53:23-37. 2013..The extent of aggregation is the main determinant of low shear blood viscosity, thus predicting an inverse relationship between aggregation and in vivo blood flow...
- Predicting human blood viscosity in silicoDmitry A Fedosov
Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Julich, 52425 Julich, Germany
Proc Natl Acad Sci U S A 108:11772-7. 2011..molecular dynamics and two different red blood cell models, we accurately predict the dependence of blood viscosity on shear rate and hematocrit...
- Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammationDanitza Nebor
Inserm U763, Pointe a Pitre, Guadeloupe
Haematologica 96:1589-94. 2011..The aim of the present study was to compare the autonomic nervous system activity, blood rheology, and inflammation in patients with sickle cell anemia according to the frequency of acute pain crisis...
- Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery StudyIoanna Tzoulaki
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
Circulation 115:2119-27. 2007....
- Erythrocyte transport efficacy of human blood: a rheological point of viewL Bogar
University of Pecs, Pecs, Hungary
Eur J Clin Invest 35:687-90. 2005..It was previously noted that delineating the corresponding haematocrit/blood viscosity ratios in the function of haematocrit provided a distribution of an inverted U-shaped curve...
- Exercise hemorheology: classical data, recent findings and unresolved issuesPhilippe Connes
UMR Inserm U665, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe
Clin Hemorheol Microcirc 53:187-99. 2013..Acute exercise is associated with a rise in hematocrit which results in an increase in blood viscosity. Whereas increased blood viscosity was previously viewed as having negative consequences for cardiovascular ..
- The acute effects of resistance exercise on the main determinants of blood rheologySajad Ahmadizad
Faculty of Science, School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
J Sports Sci 23:243-9. 2005....
- Rheopheresis for idiopathic sudden hearing loss: results from a large prospective, multicenter, randomized, controlled clinical trialRalph Mosges
Institute of Medical Statistics, Informatics und Epidemiology, University of Cologne, Lindenburger Allee 42, 50931, Cologne, Germany
Eur Arch Otorhinolaryngol 266:943-53. 2009..Also, this may be a second line treatment option for patients refractory to i.v. corticosteroids or hemodilution...
- Morning increase of whole blood viscosity in obstructive sleep apnea syndromeL Nobili
Dept of Motor Sciences Center for Sleep Medicine, University of Genoa, Ospedale S Martino, Genova, Italy
Clin Hemorheol Microcirc 22:21-7. 2000..A relative morning hyperviscosity could be one of the leading mechanisms of cardiovascular morbidity which is actually known to be especially high in the morning hours...
- Exercise hemorheology as a three acts play with metabolic actors: is it of clinical relevance?Jean Frederic Brun
Service Central de Physiologie Clinique, Centre d Exploration et de Réadaptation de Anomalies du Métabolisme Musculaire, CHU Lapeyronie, Montipellier, France
Clin Hemorheol Microcirc 26:155-74. 2002..Hemorheological measurements require to be studied, at least as sensitive markers of training, and possibly as "true" risk factors highly sensitive to exercise intensification...
- Microvascular blood viscosity in vivo and the endothelial surface layerA R Pries
Charite Berlin, Dept of Physiology, Arnimallee 22, D 14195 Berlin, Germany
Am J Physiol Heart Circ Physiol 289:H2657-64. 2005..microvascular flow resistance as a function of vessel diameter and hematocrit in vivo; it combines in vitro blood viscosity with effects of a diameter-dependent ESL...
- Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidenceB Y Salazar Vázquez
Faculty of Medicine, Universidad Juarez del Estado de Durango, Victoria de Durango, Dgo, Mexico
Clin Hemorheol Microcirc 44:75-85. 2010Decreasing blood viscosity has been proposed since the advent of hemodilution as a means for increasing perfusion in many pathological conditions, and increased plasma viscosity is associated with the presence of pathological conditions...
- Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosityS J Rim
Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA, USA
Circulation 104:2704-9. 2001..We, therefore, hypothesized that abnormal coronary blood flow (CBF) reserve observed during hyperlipidemia is secondary to increased blood viscosity and not abnormal coronary vasomotion.
- Rheologic behavior of sickle and normal red blood cell mixtures in sickle plasma: implications for transfusion therapyTamas Alexy
Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Transfusion 46:912-8. 2006..20-0.40), the proportion of SS RBCs (0-100%), and shear rate (1-1000/sec) for mixtures of oxygenated and deoxygenated SS and AA RBCs were evaluated in sickle plasma at 37 degrees C...
- Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?Pedro Cabrales
La Jolla Bioengineering Institute, La Jolla, California 92037, USA
Shock 27:380-9. 2007..systemic and microvascular conditions after volume restitution with plasma seems to be due to the decrease in blood viscosity. Conversely, the restoration of blood rheological properties improves resuscitation independently of the ..
- Haemorheology in exercise and trainingMahmoud S El-Sayed
Faculty of Science, School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, England
Sports Med 35:649-70. 2005..The acute increase in whole blood viscosity may unfavourably affect the microcirculatory blood flow and oxygen delivery to the tissues...
- In vitro effects of different medium molecular hydroxyethyl starch solutions and lactated Ringer's solution on coagulation using SONOCLOTC J Konrad
Department of Anesthesiology and Intensive Care, Ruprecht Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany
Anesth Analg 90:274-9. 2000..000 seems preferable regarding some aspects of clot formation and retraction. RL affected clot formation only minimally, except for the early activation of clotting, which was measured by a shortened activated clotting time...
- Association between hematological parameters and high-density lipoprotein cholesterolPatrick M Moriarty
Department of Internal Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Curr Opin Cardiol 20:318-23. 2005..One mechanism by which high-density lipoprotein cholesterol protects the vascular system includes hemorheology, the study of blood flow...
- Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosityJohannes Vogel
Institute of Veterinary Physiology, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
Blood 102:2278-84. 2003..Although plasma viscosity did not differ between tg and wt mice, tg whole-blood viscosity increased to a lower degree (4-fold) than expected from corresponding hemoconcentrated wt blood (8-fold)...
- Interaction between inflammation and blood viscosity predicts cardiovascular mortalityPer Torger Skretteberg
Department of Cardiology, Oslo University Hospital, Ullevaal, Oslo, Norway
Scand Cardiovasc J 44:107-12. 2010Inflammation and increased blood viscosity are associated with increased risk of cardiovascular mortality...
- Inter-species differences in hematocrit to blood viscosity ratioN Nemeth
Department of Operative Techniques and Surgical Research, Institute of Surgery, Medical and Health Science Center, University of Debrecen, Hungary
Biorheology 46:155-65. 2009Hematocrit (Hct) is the major determinant of whole blood viscosity and of its oxygen binding capacity: with increasing Hct, viscosity increases exponentially and oxygen capacity increases linearly...
- Gender differences in hemorheological parameters of coronary artery disease patientsL Bogar
Department of Anesthesiology and Intensive Care, University of Pecs, Hungary
Clin Hemorheol Microcirc 35:99-103. 2006Plasma fibrinogen concentration, plasma and whole blood viscosity (WBV) are independent risk factors of coronary artery disease (CAD)...
- Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapyJon Detterich
Division of Cardiology, Children s Hospital Los Angeles, California 90027, USA
Transfusion 53:297-305. 2013..including percent hemoglobin (Hb)S, reticulocyte count, and circulating cell-free Hb, it increases blood viscosity, which reduces microvascular flow...
- Time course and mechanisms of mental stress-induced changes and their recovery: hematocrit, colloid osmotic pressure, whole blood viscosity, coagulation times, and hemodynamic activityDolf de Boer
Behavioural Medicine Group, School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
Psychophysiology 44:639-49. 2007The mechanisms for stress-induced changes in hematocrit and blood viscosity are unclear. Twenty-two males completed experimental (30 min baseline, 10 min mental stress, 30 min recovery) and no-stress control conditions (70 min)...
- Both overall adiposity and abdominal adiposity increase blood viscosity by separate mechanismsJean Frederic Brun
Physiopathologie and Médecine Expérimentale du Coeur et des Muscles INSERM U1046, Unité d Explorations Métaboliques CERAMM, Service Central de Physiologie Clinique, Hopital Lapeyronie CHU Montpellier, France
Clin Hemorheol Microcirc 48:257-63. 2011..BMI and WHR are correlated to each other (r = 0.269; p = 0.009) and are both predictors of blood viscosity (BMI: r = 0.15516; p = 0.004; WHR: r = 0.3638; p = 0.03)...
- Reciprocal relationships between blood lactate and hemorheology in athletes: another hemorheologic paradox?Emmanuelle Varlet-Marie
Laboratoire de Pharmacocinetique Clinique, Faculte de Pharmacie, Universite Montpellier I, France
Clin Hemorheol Microcirc 30:331-7. 2004..However, we have repeatedly observed that the rise in blood lactate during exercise is correlated to blood viscosity and red cell aggregation...
- Obstructive sleep apnea syndrome: blood viscosity, blood coagulation abnormalities, and early atherosclerosisDomenico Maurizio Toraldo
Third Division, A Galateo Lung Disease Hospital, ASL Lecce, via a c Casetti n 2, 73100, Lecce, Italy
Lung 191:1-7. 2013..Recent investigations of atherosclerosis in OSAS have focused on thrombotic tendency and blood viscosity, providing new insight into mechanisms of the disease...
- Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemiaYann Lamarre
Institut National de la Santé et de la Recherche Médicale UMR 665, Hôpital RICOU, Centre Hospitalier Universitaire de Pointe à Pitre, Pointe a Pitre, Guadeloupe
PLoS ONE 8:e66004. 2013..We compared the hematological, lipid and hemolytic profiles, as well as blood viscosity, between SCA patients with normal BP (<120/70 mmHg, n = 54) and those with relative hypertension (BP≥..
- Effect of hematocrit on blood pressure via hyperviscosityY Cinar
Haydarpasa Numune Hospital, Istanbul, Turkey
Am J Hypertens 12:739-43. 1999Increase in blood viscosity, defined as resistance to flow, is one factor in hypertension and atherosclerosis that contributes to the morbidity and mortality associated with tissue ischemia...
- Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosusStephanie Booth
University of Chicago, Chicago, Illinois 60637, USA
Arthritis Rheum 57:845-50. 2007To determine if whole blood viscosity (WBV), a rheologic variable contributing to risk of myocardial infarction and stroke in the general population, is elevated in patients with systemic lupus erythematosus (SLE), particularly SLE ..
- Gender- and age-related variations in blood viscosity in normal volunteers: a study of the effects of extract of Allium sativum and Ginkgo bilobaJ C F Galduróz
Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Brazil
Phytomedicine 14:447-51. 2007This study sought to compare the effects of age and gender on blood viscosity and to appraise the effectiveness of Ginkgo biloba and Allium sativum extracts in reducing blood viscosity...
- Whole blood viscosity and microvascular abnormalities in Alzheimer's DiseaseM Meighan Smith
Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Clin Hemorheol Microcirc 41:229-39. 2009..that abnormalities in hemorheologic parameters, including vessel diameter, flow velocity, and whole blood viscosity (WBV), would be present in Alzheimer's Disease (AD) and would correlate with microvascular abnormalities (..
- Oxygen delivery index in subjects with normal haemoglobin (HbAA), sickle cell trait (HbAS) and homozygous sickle cell disease (HbSS)A S Bowers
Department of Basic Medical Sciences, Physiology Section, Faculty of Medical Sciences, University of the West Indies, Jamaica, West Indies
Clin Hemorheol Microcirc 40:303-9. 2008..Whole blood viscosity was measured at low and high shear rates of 23 s(-1) and 230 s(-1), respectively, using a Wells Brookfield ..
- Hemorheology and hypertension: not "chicken or egg" but two chickens from similar eggsL Bogar
Department of Anesthesia and Intensive Therapy, University of Pecs, Hungary
Clin Hemorheol Microcirc 26:81-3. 2002..demonstrated significant positive correlation between the severity of arterial hypertension (AHT) and whole blood viscosity. Red blood cell aggregation has also been associated with AHT especially in the severe form of the disease...
- The influence of flow, vessel diameter, and non-newtonian blood viscosity on the wall shear stress in a carotid bifurcation model for unsteady flowFrieke M A Box
Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Invest Radiol 40:277-94. 2005..We investigated the effects of non-Newtonian blood viscosity, variations in flow rate, and vessel diameter on wall phenomena in a carotid bifurcation model.
- Blood viscosity changes in experimentally Trypanosoma cruzi-infected ratsH H Berra
Cátedra Fisiología Humana, Departamento de Ciencias Fisiologicas, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina
Clin Hemorheol Microcirc 32:175-82. 2005..We studied whole blood viscosity (eta(b)) and plasmatic and cellular factors influencing it in rats, 7 and 14 days after experimental ..
- Free oscillation rheometry detects changes in clot properties in pregnancy and thrombocytopeniaNahreen Tynngård
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Linkoping, Sweden
Platelets 19:373-8. 2008..The results suggest that FOR can provide new information on the haemostatic status of patients at risk of thrombotic or bleeding events as well as information on the haemostatic effect of a platelet transfusion...
- Influence of contrast media (iopromide, ioxaglate, gadolinium-DOTA) on blood viscosity, erythrocyte morphology and platelet functionWalter H Reinhart
Department of Internal Medicine, Kantonsspital, CH 7000 Chur, Switzerland
Clin Hemorheol Microcirc 32:227-39. 2005The influence of contrast media on blood viscosity, erythrocyte morphology and platelet function was studied. In vitro blood was incubated with iopromide (Ultravist), ioxaglate (Hexabrix) or gadolinium-DOTA (Dotarem)...
- Blood viscosity and the expression of inflammatory and adhesion markers in homozygous sickle cell disease subjects with chronic leg ulcersAndre S Bowers
Department of Basic Medical Sciences, Physiology Section, University of the West Indies, Mona, Kingston 7, Jamaica
PLoS ONE 8:e68929. 2013To determine differences in TNF-α, IL-1β, IL-10, sICAM-1 concentrations, leg hypoxia and whole blood viscosity (WBV) at shear rates of 46 sec(-1) and 230 sec(-1) in persons with homozygous S sickle cell disease (SCD) with and without ..
- Whole blood viscosity, plasma viscosity and erythrocyte aggregation in nine mammalian species: reference values and comparison of dataU Windberger
Institute for Biomedical Research, University of Vienna, Währingergürtel 18 20, Austria
Exp Physiol 88:431-40. 2003In this study species-specific values for whole blood viscosity (WBV), plasma viscosity (PV) and erythrocyte aggregation (EA) were determined in a total of 360 animals...
- Role of plasma proteins in whole blood viscosity: a brief clinical reviewHau C Kwaan
Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Clin Hemorheol Microcirc 44:167-76. 2010Whole blood viscosity is affected by a number of factors, among which plasma proteins are a major component. They exert their effects either directly or through their influence on red cell aggregation...
- Blood viscosity and elevated carotid intima-media thickness in men and women: the Edinburgh Artery StudyA J Lee
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, Edinburgh University Medical School, UK
Circulation 97:1467-73. 1998..We therefore studied the relationship between these factors and carotid intima-media thickness (IMT)...
- Lack of association between systolic blood pressure and blood viscosity in normotensive healthy subjectsConcetta Irace
Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Magna Græcia University, Catanzaro, Italy
Clin Hemorheol Microcirc 51:35-41. 2012..To better understand the relationship between these two variables, we evaluated blood viscosity and blood pressure in a group of healthy subjects without cardiovascular risk factors.
- Blood viscosity and hemodynamics during exercisePhilippe Connes
Laboratoire ACTES, Departement de Physiologie, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe, France
Clin Hemorheol Microcirc 51:101-9. 2012We tested the effects of submaximal exercise on blood viscosity (η(b)), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated...
- Oxygen delivery index in homozygous sickle cell disease: steady and crisis statesA S Bowers
Department of Basic Medical Sciences, Physiology Section, University of the West Indies, Mona Campus, Kingston 7, Jamaica, West Indies
Br J Biomed Sci 66:148-9. 2009..Whole blood viscosity was measured with a Wells Brookfield viscometer at a shear rate of 230 sec(-1) and haematocrit was measured ..
- Blood viscosity and hematological changes during prolonged submergence in normoxic water of northern and southern musk turtles (Sternotherus odoratus)D K Saunders
Division of Biological Sciences, Emporia State University, Kansas 66801, USA
J Exp Zool 287:459-66. 2000..We investigated the effects of submergence in normoxic water at 3 degreesC on the blood viscosity of musk turtles from northern (Massachusetts) and southern (Alabama) locales...
- High blood viscosity is closely associated with cigarette smoking and markedly reduced by smoking cessationSayaka Shimada
Clinical Research Institute, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
Circ J 75:185-9. 2011..The rheological properties of blood assessed by the microchannel method reflect the blood's viscosity and the state of microthrombus formation, which may predict cardiovascular thrombotic events...
- Hemorheologic alterations in hypertension: chicken or egg?H J Meiselman
Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles 90033, USA
Clin Hemorheol Microcirc 21:195-200. 1999....
- Blood pressure and blood viscosity are not correlated in normal healthy subjectsBeatriz Y Salazar Vázquez
Departamento de Medicina Experimental, Universidad Nacional Autonoma de Mexico, Hospital General de Mexico, Mexico DF, Mexico
Vasc Health Risk Manag 8:1-6. 2012The relationship between blood viscosity, hematocrit (Hct), and mean arterial blood pressure (MAP) was studied in a healthy population of 91 men and 66 women with an average age of 30.6 ± 8...
- Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacityPedro Cabrales
La Jolla Bioengineering Institute, La Jolla, CA, USA
Am J Physiol Heart Circ Physiol 291:H581-90. 2006..Thus the fall in systemic and microvascular conditions during extreme hemodilution with low-viscosity plasma expanders seems to be, in part, from the decrease in blood viscosity independent of the reduction in oxygen content.
- Relationship between hemorheological factors and insulin sensitivity in normotensive and hypertensive premenopausal womenG Nordby
Department of Internal Medicine, Ullevaal Hospital, University of Oslo, Norway
Am J Hypertens 8:439-44. 1995..study aimed at testing a possible relationship between hemorheologic factors such as hematocrit and whole blood viscosity, and insulin sensitivity in premenopausal, hypertensive (HT), and normotensive (NT) women...
- Effects of 6-h exposure to low relative humidity and low air pressure on body fluid loss and blood viscosityN Hashiguchi
Department of Health Science, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Indoor Air 23:430-6. 2013..relative humidity (RH) and low air pressure in a simulated air cabin environment on body fluid loss (BFL) and blood viscosity. Fourteen young healthy male subjects were exposed to four conditions, which combined RH (10% RH or 60% RH) ..
- Modulation of red blood cell aggregation and blood viscosity by the covalent attachment of Pluronic copolymersJ K Armstrong
Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Biorheology 38:239-47. 2001..property of Pluronics has been utilized to enhance or inhibit RBC aggregation and hence to vary low-shear blood viscosity. Pluronic-coated RBCs were prepared using reactive DT derivatives of a range of Pluronics (F68, F88, F98 and ..
- Cerebrospinal fluid viscosity: a novel diagnostic measure for acute meningitisFunda Yetkin
Department of Infectious Disease, Inonu University School of Medicine, Malatya, Turkey
South Med J 103:892-5. 2010..It has been previously reported that plasma viscosity can be used as an inflammatory marker. In this study we aimed to evaluate the role of CSF viscosity as a complementary measure for diagnosis of meningitis in suspected patients...
- High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion triggerA G Tsai
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Biorheology 38:229-37. 2001..studies lead to the axiom that high plasma viscosity is detrimental and that it is beneficial to lower blood viscosity, a precept embodied in the practice of hemodilution, where improved perfusion is attributed to the lowering ..
- Molecular biology and self-regulatory mechanisms of blood viscosity: a reviewW H Reinhart
Department of Internal Medicine, Kantonsspital, Chur, Switzerland
Biorheology 38:203-12. 2001b>Blood viscosity is determined by plasma viscosity, hematocrit, erythrocyte deformability and aggregation. Plasma viscosity and hematocrit are directly regulated by the organism...
- Hemorheological changes and overproduction of cytokines from immune cells in mild to moderate dementia of the Alzheimer's type: adverse effects on cerebromicrovascular systemS B Solerte
Department of Internal Medicine, Geriatrics and Gerontology Clinic, School of Geriatrics, University of Pavia, Ospedale S Margherita, Piazza Borromeo 2, 27100, Pavia, Italy
Neurobiol Aging 21:271-81. 2000....
- Changes of blood viscosity in patients treated with 5-fluorouracil--a link to cardiotoxicity?M Cwikiel
Department of Oncology, University Hospital Lund, Sweden
Acta Oncol 34:83-5. 1995..The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients...
- The influence of lipoproteins on whole-blood viscosity at multiple shear ratesArnold Slyper
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Metabolism 54:764-8. 2005Whole-blood viscosity appears to be an independent predictor of stroke, carotid intima-media thickening, and carotid atherosclerosis...
- Treatment with aspirin and dipyridamole is more effective than aspirin in reducing low shear blood viscosityRobert S Rosenson
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48106, USA
Microcirculation 15:615-20. 2008Investigate effects of aspirin/dipyridamole and aspirin on blood viscosity (BV) in subjects with hyperhomocystememia (>14 micromol/L) and stable cardiovascular disease (CVD) or >or= 20% risk for CVD were the aims of this study.
- Effects of oral acrylamide intake on blood viscosity parameters in ratsOkan Arihan
Faculty of Medicine, Department of Physiology, Hacettepe University, Ankara, Turkey
Clin Hemorheol Microcirc 47:45-52. 2011..of chronic administration of acrylamide at a dose which does not induce neurotoxicity were evaluated on blood viscosity parameters (hematocrit, erythrocyte deformability, erythrocyte aggregation and plasma viscosity)...
- Effect of immunoglobulin therapy on blood viscosity and potential concerns of thromboembolism, especially in patients with acute Kawasaki diseaseReizo Baba
Department of Paediatrics, Aichi Medical University School of Medicine, Aichi Gun, Aichi, Japan
Recent Pat Cardiovasc Drug Discov 3:141-4. 2008..High levels of IgG, immune complex formation, and increased platelet aggregation could increase blood viscosity after IVIG infusion...
- Improved treatment of sudden hearing loss by specific fibrinogen aphaeresisHeidrun Ullrich
Institute of Transfusion Medicine, University of Hamburg, Hamburg, Germany
J Clin Apher 19:71-8. 2004..Clin. Immunol. Immunopath. 68:41-45, 1993; Gussen, Ann. Otol. Rhinol. Laryngol. 85:94-100, 1976]. Elevated blood viscosity due to high fibrinogen levels is supposed to cause decreased cochlear blood flow and thus initiate sudden ..
- Does carbonyl stress cause increased blood viscosity during storage?Guolin Li
The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
Clin Hemorheol Microcirc 44:145-54. 2010..However, the biochemical mechanisms are only partly understood...
- Prognostic impact of low-shear whole blood viscosity in hypertensive menG Ciuffetti
Unit of Internal Medicine, Angiology and Atherosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, 06156 Perugia, Italy
Eur J Clin Invest 35:93-8. 2005The role of blood viscosity as a marker for discriminating cardiovascular risk in essential hypertension remains uncertain...
- Hyperviscosity syndrome in plasma cell dyscrasiasJayesh Mehta
The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
Semin Thromb Hemost 29:467-71. 2003..Immediate therapy of symptomatic hyperviscosity is directed at reduction of blood viscosity by plasmapheresis to control symptoms...
- Physical activity, cardiorespiratory fitness, and the primary components of blood viscosityS Carroll
School of Leisure and Sports Studies, Leeds Metropolitan University, Beckett Park Campus, United Kingdom
Med Sci Sports Exerc 32:353-8. 2000....
- Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacityPedro Cabrales
La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
Resuscitation 75:124-34. 2007....
- Is hemoglobin desaturation related to blood viscosity in athletes during exercise?P Connes
UPRES EA 2991 Sport, Performance et Santé, Montpellier, France
Int J Sports Med 25:569-74. 2004..b>Blood viscosity may be implicated in exercise-induced pulmonary hemorrhage in race horses...
- Reduction of red blood cell disaggregability during submaximal exercise: relationship with fibrinogen levelsE Varlet-Marie
Laboratoire de Pharmacocinetique Clinique, Faculte de Pharmacie, Universite Montpellier I, France
Clin Hemorheol Microcirc 28:139-49. 2003..High shear rate viscometry (1000 s(-1) evidenced an increase in blood viscosity explained by an increase in hematocrit (+8% p<0.01) and plasma viscosity (+7% p<0.01)...
- Pleiotropic effects of LDL apheresisAlfonso Ramunni
Division of Nephrology, Department of Internal and Public Medicine, University of Bari, Bari, Italy
Atheroscler Suppl 10:53-5. 2009..Besides these actions, LA improves whole blood viscosity and endothelium-mediated vasodilation, and has a positive effect on the hemorheological picture, improving ..
- Association among low whole blood viscosity, haematocrit, haemoglobin and diabetic retinopathy in subjects with type 2 diabetesC Irace
Department of Clinical and Experimental Medicine G Salvatore, University Magna Græcia of Catanzaro, Catanzaro, Italy
Br J Ophthalmol 95:94-8. 2011..Clinical studies have described an association among blood viscosity, haematocrit, haemoglobin and macro-angiopathy...
- Platelet aggregation, blood viscosity and serum lipids in hypertensive and obese childrenIbolya Haszon
Department of Paediatrics, University of Szeged, Koranyi fasor 14 15, Hungary
Eur J Pediatr 162:385-90. 2003..Multivariate analysis revealed significant interactions in the effects of obesity and hypertension on platelet aggregation and thiol oxidation...
- Acidosis induced by lactate, pyruvate, or HCl increases blood viscosityWalter H Reinhart
Department of Internal Medicine, Kantonsspital, Chur, Switzerland
J Crit Care 17:68-73. 2002..It is not clear if lactate is only a marker or a mediator of disease. We tested the hypothesis that acidosis induced by lactate and pyruvate affects blood flow properties...
- Temporal effect of Guanxin No. 2 on cardiac function, blood viscosity and angiogenesis in rats after long-term occlusion of the left anterior descending coronary arteryXiaowei Zeng
College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, PR China
J Ethnopharmacol 118:485-94. 2008..2 decoction (GX II) on cardiac dysfunction combined with the blood viscosity and myocardial hypertrophy parameters in myocardial infarction (MI) rats.
- Reducing blood viscosity with magnetic fieldsR Tao
Department of Physics, Temple University, Philadelphia, Pennsylvania 19122, USA
Phys Rev E Stat Nonlin Soft Matter Phys 84:011905. 2011b>Blood viscosity is a major factor in heart disease. When blood viscosity increases, it damages blood vessels and increases the risk of heart attacks...
- Hematocrit and mean arterial blood pressure in pre- and postmenopause womenBeatriz Y Salazar Vázquez
Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037 0412, USA
Vasc Health Risk Manag 5:483-8. 2009..in endothelial function where menopause decreases the capacity of the endothelium to respond to increased blood viscosity and shears stress, leading to the increased production of vasodilator mediators to compensate for changes in ..
- Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normalsBeatriz Y Salazar Vázquez
Faculty of Medicine, Universidad Juarez del Estado de Durango, Durango, Dgo, Mexico
Clin Hemorheol Microcirc 44:55-61. 2010To determine the relationship between mean arterial blood pressure (MAP) and blood viscosity in diabetic type 1 children and healthy controls to investigate whether MAP is independent of blood viscosity in healthy children, and vice versa.
- Effect of n-tyrosol on blood viscosity and platelet aggregationM B Plotnikov
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk
Bull Exp Biol Med 143:61-3. 2007Experiments on rats showed that n-tyrosol limited the increase in blood viscosity during thermal exposure at a shear rate of 5-300 sec(-1) and inhibited ADP-induced platelet aggregation...
- Blood viscosity, hemodynamics and vascular hindrance in a rat model of acute controlled bleeding and volume restitution with blood or HaemaccelN Hilzenrat
Gastroenterology Division, The Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Acta Anaesthesiol Scand 45:371-6. 2001Hemorrhage and volume restitution with commercially available solutions is followed by reduced blood viscosity. Consequent hemodynamic changes may arise not only from the reduced viscosity itself but also from changes in vascular ..
- Cognitive performance, SPECT, and blood viscosity in elderly non-demented people using Ginkgo bilobaR F Santos
Department of Psychobiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Brazil
Pharmacopsychiatry 36:127-33. 2003..possible number of functions including Single Photon Emission Computer Tomography (SPECT) and measures of blood viscosity. The study was run on a double-blind basis with placebo and Ginkgo biloba groups evaluated over a period of 8 ..
- Model-independent relationships between hematocrit, blood viscosity, and yield stress derived from Couette viscometry dataY Leong Yeow
Department of Chemical Engineering, The University of Melbourne, Melbourne, Victoria, Australia
Biotechnol Prog 18:1068-75. 2002....
- Low hematocrit per blood viscosity ratio as a mortality risk factor in coronary heart diseaseP Kenyeres
1st Department of Medicine, University of Pecs, Hungary
Clin Hemorheol Microcirc 38:51-6. 2008Increased blood viscosity has not been associated with mortality risk in coronary heart disease (CHD)...
- Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilutionDavid S Long
Department of Mechanical and Industrial Engineering, University of Illinois at Urbana Champaign, Urbana, 61801, USA
Proc Natl Acad Sci U S A 101:10060-5. 2004..Radial distributions in blood viscosity, shear stress, and shear rate are obtained and used to predict axial pressure gradient, apparent viscosity, ..
- Cardiovascular risks of anemia correction with erythrocyte stimulating agents: should blood viscosity be monitored for risk assessment?Seul Ki Jeong
Department of Neurology and Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, South Korea
Cardiovasc Drugs Ther 24:151-60. 2010..risk of CVD among certain patients treated with ESAs and suggests a risk management approach based on blood viscosity. Whole blood viscosity is a key determinant of the work of the heart, and elevated blood viscosity appears to ..
- Blood viscosity: effects of mental stress and relations to autonomic nervous system function and insulin sensitivityHenrik M Reims
Department of Cardiology, University of Michigan, Ann Arbor, MI, USA
Blood Press 14:159-69. 2005We studied effects of mental stress on whole-blood viscosity (WBV) and blood pressure (BP), and relations between WBV and autonomic nervous system activity and insulin sensitivity...
- White blood cell and platelet counts could affect whole blood viscosityChao Hung Ho
Division of Hematology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
J Chin Med Assoc 67:394-7. 2004b>Blood viscosity is correlated with cerebral blood flow and cardiac output, and increased viscosity may increase the risk of thrombosis or thromboembolic events...
- Reduced cerebral blood flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic mice with excessive erythrocytosisThomas Frietsch
Department of Anesthesiology and Critical Care Medicine, Faculty of Clinical Medicine Mannheim, Mannheim, Germany
J Cereb Blood Flow Metab 27:469-76. 2007..Hemodilution suggests that high blood viscosity is a cause of the decrease in CBF and partly of the increase in CMR(glc)...
- Effects of high and low inspired fractions of oxygen on horse erythrocyte membrane properties, blood viscosity and muscle oxygenation during anaesthesiaKarine Portier
Ecole Nationale Veterinaire de Lyon, Equine Department, Universite de Lyon, Lyon, France
Vet Anaesth Analg 36:287-98. 2009..To evaluate whether a period of hyperoxia or after a period of hypoxia produced changes attributable to reactive oxygen species in anaesthetized horses...
- The influence of priming solutions used in cardiopulmonary bypass on blood viscosity in hypothermic conditionsSinasi Manduz
Cumhuriyet University, Cardiovascular Surgery, Sivas, Turkey
ASAIO J 54:275-7. 2008..This study aimed to demonstrate the alteration of blood viscosity following dilution with priming solutions: hydroxyethyl starch (HES), gelatin, albumin, and Ringer's lactated ..
- The variability of blood pressure due to small changes of hematocritBeatriz Y Salazar Vázquez
Faculty of Medicine, Universidad Juarez del Estado de Durango, Victoria de Durango, Durango, Mexico
Am J Physiol Heart Circ Physiol 299:H863-7. 2010..by isovolemic hemodilution using hamster plasma to determine the acute effect of small changes in Hct and blood viscosity on systemic hemodynamics...
- Opposite effects of low-density and high-density lipoprotein on blood viscosity in fasting subjectsG D Sloop
Department of Pathology, Louisiana State University Medical Center in New Orleans, 70112, USA
Clin Hemorheol Microcirc 19:197-203. 1998Given the enlarging body of evidence implicating increased blood viscosity in atherogenesis, the authors hypothesize that lipoproteins modulate the atherogenic process by affecting blood viscosity...
- Effects of a moderate-intensity aerobic program on blood viscosity, platelet aggregation and fibrinolytic balance in young and middle-aged sedentary subjectsLudovico Coppola
Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Policlinico Universitario, Naples, Italy
Blood Coagul Fibrinolysis 15:31-7. 2004..that moderate-intensity aerobic training improves fibrinolytic activity and reduces platelet aggregation and blood viscosity. In 15 young (11 males and four females; age, 24-32 years) and 15 middle-aged (11 males and four females; age,..
- Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window modelJudith Martini
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 291:H310-7. 2006..We conclude that a minimum viscosity level is necessary for generating the shear stress required for maintaining normal cardiovascular function...
- Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus: the atherosclerosis risk in communities (ARIC) studyLeonardo J Tamariz
Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
Am J Epidemiol 168:1153-60. 2008Several lines of evidence support the notion that elevated blood viscosity may predispose to insulin resistance and type 2 diabetes mellitus by limiting delivery of glucose, insulin, and oxygen to metabolically active tissues...
- Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusionAmy G Tsai
Dept of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 288:H1730-9. 2005..between perivascular NO concentration and the locally calculated shear stress induced by the procedures, when blood viscosity was corrected according to Hct values previously determined in studies of microvascular Hct distribution...
- Effect of hemodialysis on whole blood viscosityS Vaisman
Pottstown Medical Specialists, Inc, Phoenixville, PA, USA
Int J Artif Organs 32:329-35. 2009..The purpose of the present study was to examine the effect of hemodialysis procedures on the hemoconcentration status of end-stage renal disease (ESRD) patients...
- Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosityEszter Pais
Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Clin Hemorheol Microcirc 35:139-42. 2006..hemorheological parameters and thus we have begun to assess the effects of the enzyme on RBC aggregation and blood viscosity. Blood samples were incubated with nattokinase (final activities of 0, 15.6, 31.3, 62...
- Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangreneMaia Mantskava
Microcirculation Research Center, I Beritashvili Institute of Physiology, 14 Gotua St, 0160 Tbilisi, Georgia
Clin Hemorheol Microcirc 35:307-10. 2006..The disturbed blood fluidity related to the increased RBC aggregability in the microcirculation promotes, in particular, the development of legs gangrene in both types of diabetes mellitus...
- Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular ReactivityDeidre Wipke Tevis; Fiscal Year: 2009..Preliminary data in healthy men suggest that hematocrit (Hct, a determinant of blood viscosity) peaks while plasma nitrite/nitrate (NOx, a stable metabolite of the vasodilator molecule, nitric oxide) ..
- Impact of Blood Viscosity on Oxygen Delivery in humans with Sickle Cell AnemiaTHOMAS DUANE COATES; Fiscal Year: 2011..The pathophysiology of SCD is due in part to the increase in blood viscosity caused by hemoglobin S (HbS)...
- Cytotoxic Heat Transfer and Thrombotic Risk in Microwave Tumor AblationCHIH SHENG J CHIANG; Fiscal Year: 2013..of this project will lead to better understanding of coupling electromagnetic analysis with thermal flow, blood viscosity changes in a high-temperature environment and endothelial damage near microwave ablation zones...
- POLYMER-COATED RED BLOOD CELL FOR SICKLE CELL DISEASETIMOTHY FISHER; Fiscal Year: 2003..interactions, such as RBC aggregation, are minimized; the latter effect results in greatly reduced low-shear blood viscosity even when the hematocrit of SS blood is increased with coated RBC...
- Resuscitating Blood-Substituted Hypothermic DogsHal Sternberg; Fiscal Year: 2005..Sludging of blood in the microvasculature (hypothermia increases blood viscosity) causes blockage of the microvasculature of the major organs during the period of circulatory arrest...
- ERYTHROPOIETIC AND HEMODYNAMIC RESPONSE TO HYPOXEMIAJohn Widness; Fiscal Year: 1990..in erythropoietic (Ep, Hb, reticulocytes, and red cell mass), hemodynamic (blood pressure, heart rate, whole blood viscosity, and regional blood flow), and growth parameters (organ and body weights, and length measurements) will be ..
- EVALUATION OF DIAGNOSTIC CLINICAL HEMORRHEOLOGYGEOFFREY SEAMAN; Fiscal Year: 1980The program is evaluating blood viscosity associated variables (apparent blood viscosity at various rates of shear, hematocrit, red cell deformability, fluidity and size, degree of cellular aggregation, plasma viscosity, serum protein ..
- DIVERGENCE OF BLOOD PRESSURE BY RACE IN ADOLESCENT GIRLSStephen Daniels; Fiscal Year: 2000..blood volume (left ventricular end-diastolic volume), heart rate, left ventricular contractility, whole blood viscosity, and left ventricular mass and geometry will be measured...
- Improving Functioning in Peripheral Arterial DiseaseMary McDermott; Fiscal Year: 2007..Mechanisms we will study include changes in blood viscosity, peak oxygen consumption (VO2), calf blood flow, brachial artery endothelial reactivity, and inflammatory ..
- ULTRASONIC BLOOD VISCOMETERCraig Hartley; Fiscal Year: 2001DESCRIPTION (Verbatim from Applicant's Abstract): Blood viscosity is altered in diseases such as sickle cell anemia, hypertension, and atherosclerosis and also during coagulation, but its measurement requires complex and expensive ..
- IN VIVO MEASUREMENT OF WALL SHEAR STRESS IN THE AORTAGerald Miller; Fiscal Year: 1980..This information can aid in monitoring flush conditions between the hot film probe and aortic wall. Blood viscosity is computed from blood hematocrit measurements...
- BIOENGINEERING DESIGN OF ARTIFICIAL BLOODMarcos Intaglietta; Fiscal Year: 2004..is that when a blood replacement fluid is introduced in the circulation it should cause the resulting blood viscosity to remain sufficiently elevated to insure the adequate generation of shear stress at the-blood/tissue ..
- DISPOSABLE BLOOD VISCOMETERNOH PARK; Fiscal Year: 1992b>Blood viscosity can be a powerful diagnostic tool for early detections of cancer, heart disease, peripheral arterial disease, abnormal hemoglobin, or some immunological disorders...
- ANTILIPEMIC REGIMES IN PERIPHERAL ARTERIOSCLEROSISJAY COFFMAN; Fiscal Year: 1980..whether correction of lipoprotein abnormalities has a beneficial effect on the circulatory impairment in these patients, either by halting or reversing the arteriosclerotic process in the blood vessels or by a change in blood viscosity.
- Cellular imaging of blood flow rheological disordersGuy Cloutier; Fiscal Year: 2007..Among them may be cited its effect on the formation of sludge blood in microvessels, increased blood viscosity, occurrence of vascular thrombosis, and increased flow resistance...
- Phase 3 stem cell transplant for light chain amyloidosisMorie A Gertz; Fiscal Year: 2011..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
- NOVEL SEROTHERAPY STRATEGIES--PLASMA CELL MALIGNANCIESSTEVEN TREON; Fiscal Year: 2004..Analogous to our work with Muc-1, we will also attempt to identify other PCD selective targets by generating and examining mAbs specific to the plasma cell glycoform of CD138. ..
- HEMORHEOLOGY STUDIES RELATED TO IN VIVO BLOOD FLOWHERBERT MEISELMAN; Fiscal Year: 2008....
- CNS transcription modulation in peripheral inflammationMa Li Wong; Fiscal Year: 2002..The proposed studies will result in new data that will be needed for us to generate novel testable hypotheses, which will provide the framework for future R0l applications. ..
- Dose-finding, pharmacokinetic, safety and efficacy of bivalirudin in childrenGuy Young; Fiscal Year: 2009..More modern therapies are available but have not been systematically tested in children. This study will determine whether one such medication, bivalirudin is a safer and more effective alterative. ..
- CORONARY MICROCIRCULATION-ACUTE MYOCARDIAL INFARCTIONSanjiv Kaul; Fiscal Year: 2004..The study aims will be to test the 4 above-mentioned hypotheses in patients with suspected AMI. ..
- Behavioral state development in infantsMark Blumberg; Fiscal Year: 2009..abstract_text> ..
- Induction of Tissue Factor by Patient Sera in HUSEric Grabowski; Fiscal Year: 2007..A key additional feature of this proposal is the use of our newly formed collaborative group of pediatric nephrologists to facilitate patient recruitment [unreadable] [unreadable]..
- Physiological Consequences of Hypoxia and Lung DiseasePeter Wagner; Fiscal Year: 2008..abstract_text> ..
- FONDAPARINUM IN CHILDREN WITH THROMBOSISGuy Young; Fiscal Year: 2007..Pharmacokinetic analyses as well as safety and efficacy determinations will be made which will provide valuable information on this new anticoagulant for pediatric patients. [unreadable] [unreadable]..
- A Novel Polymeric Trileaflet Heart Valve ProsthesisSCOTT CORBETT; Fiscal Year: 2008..valves that improves upon the shortcomings of existing replacement valves, reduces the cost burden on the health care system and improves the survival rate of patients with heart valve prostheses [unreadable] [unreadable] [unreadable]..
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2002..4. Whether changes in blood viscosity affect coronary blood flow reserve...
- Ultrafine Particle Exposure in HumansMark Frampton; Fiscal Year: 2005..These studies will identify key mechanisms for the cardiovascular effects of exposure to ambient air particles. ..
- TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERSMarcos Intaglietta; Fiscal Year: 2009..Conventional plasma expanders (PEs) lower blood viscosity and their use beyond the transfusion trigger causes: 1) Arteriolar vasoconstriction and decreased blood flow;..
- Activation of clotting & cell adhesion: gas embolismDavid M Eckmann; Fiscal Year: 2010..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
- CARDIOVASCULAR CONCOMITANTS OF ULTRASONIC VOCALIZATIONSMark Blumberg; Fiscal Year: 2002..Through these approaches, an integrated view of the varied mechanisms by which infant and adult mammals regulate cardiovascular function during physiological and behavioral challenges will emerge. ..
- MAGNETIC RESONANCE CORONARY ANGIOGRAPHYJohn Oshinski; Fiscal Year: 2001....
- CHRONIC ISCHEMIC LEFT VENTRICULAR DYSFUNCTIONSanjiv Kaul; Fiscal Year: 2004..The drug we will test is carvedilol because of its unique adrenergic inhibitor properties as well as its anti-oxidant and anti-apoptotic properties. ..
- BLys inhibition using TACI-Fc in patients with B-bell non-Hodgkins' LymphomaStephen Ansell; Fiscal Year: 2008..abstract_text> ..
- Oral Care and Respiratory Pathogen ColonizationOzan Akca; Fiscal Year: 2004..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2004..4. Whether changes in blood viscosity affect coronary blood flow reserve...
- Nonlinear Dynamics in Microvascular NetworksRussell Carr; Fiscal Year: 2004..Oscillating flows and pressures due to nonlinear effects will also have an impact on mass transfer calculations from blood to surrounding tissues. Time varying flows are also implicated in the health of the vessel wall. ..
- Phenotype-Genotype Interactions and Type 2 DiabetesJames Meigs; Fiscal Year: 2005..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
- Relationship of Hematocrit to Ischemic Stroke OutcomePaul Diamond; Fiscal Year: 2006..HCT is the main determinant of blood oxygen carrying capacity and blood viscosity. Central Nervous System (CNS) oxygen transport diminishes at high HCT levels due to increased blood viscosity ..
- Depression/Metabolic Syndrome in Mexican-American Women.Ma Li Wong; Fiscal Year: 2006..This work will address this important area by the study of an population group who is markedly under represented in patient-oriented investigation. [unreadable] [unreadable]..
- Pharmacogenetics of Antidepressant DrugsMa Li Wong; Fiscal Year: 2007..This K-24 award will make possible for the P.I. to significantly increase her time allocation for patient-oriented research and for mentoring of junior trainees and fellows in clinical research. [unreadable] [unreadable]..
- Ultrafine Particle-Induced Oxidative StressMark Frampton; Fiscal Year: 2007..abstract_text> ..
- Functional Tissue Factor on Activated EndotheliumEric Grabowski; Fiscal Year: 2004....
- FUNCTIONAL ASPECTS OF OXYGEN DELIVERYMarcos Intaglietta; Fiscal Year: 2004..It is proposed that blood viscosity is a determinant of p02 distribution in the microcirculation because: 1) Viscosity is a factor in determining ..
- RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTIONHERBERT LIPOWSKY; Fiscal Year: 2009..reductions in flow and duration of ischemia, and compared to reductions in shear stress incurred by reducing blood viscosity using hemodilution...