vancomycin resistance

Summary

Summary: Nonsusceptibility of bacteria to the action of VANCOMYCIN, an inhibitor of cell wall synthesis.

Top Publications

  1. pmc The rise of the Enterococcus: beyond vancomycin resistance
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, Houston, Texas 77030, USA
    Nat Rev Microbiol 10:266-78. 2012
  2. pmc Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications
    Benjamin P Howden
    Department of Infectious Diseases, Austin Health, Victoria, Australia
    Clin Microbiol Rev 23:99-139. 2010
  3. ncbi Vancomycin resistance in gram-positive cocci
    Patrice Courvalin
    Unite des Agents Antibacteriens, Institut Pasteur, Paris, France
    Clin Infect Dis 42:S25-34. 2006
  4. ncbi SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 24:362-86. 2003
  5. pmc Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 46:1492-502. 2002
  6. pmc Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300
    Susana Gardete
    Laboratory of Microbiology, The Rockefeller University, New York, New York, USA
    PLoS Pathog 8:e1002505. 2012
  7. ncbi Role of environmental contamination as a risk factor for acquisition of vancomycin-resistant enterococci in patients treated in a medical intensive care unit
    Jose A Martinez
    Division of Geographic Medicine and Infectious Disease and Clinical Care Research, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Arch Intern Med 163:1905-12. 2003
  8. pmc D-Ala-d-Ser VanN-type transferable vancomycin resistance in Enterococcus faecium
    Francois Lebreton
    Interactions Hôte et Microorganismes des Epithéliums, EA2128, CHU Cote de Nacre, 14033 Caen Cedex, France
    Antimicrob Agents Chemother 55:4606-12. 2011
  9. ncbi Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene
    Soju Chang
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta 30333, USA
    N Engl J Med 348:1342-7. 2003
  10. pmc Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus
    Michael Meehl
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Antimicrob Agents Chemother 51:2679-89. 2007

Detail Information

Publications283 found, 100 shown here

  1. pmc The rise of the Enterococcus: beyond vancomycin resistance
    Cesar A Arias
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, Houston, Texas 77030, USA
    Nat Rev Microbiol 10:266-78. 2012
    ..Finally, we review the most important mechanisms of resistance to the antibiotics that are used to treat vancomycin-resistant enterococci...
  2. pmc Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications
    Benjamin P Howden
    Department of Infectious Diseases, Austin Health, Victoria, Australia
    Clin Microbiol Rev 23:99-139. 2010
    ..Given the subtleties of vancomycin susceptibility testing against S. aureus, it is imperative that diagnostic laboratories use well-standardized methods and have a framework for detecting reduced vancomycin susceptibility in S. aureus...
  3. ncbi Vancomycin resistance in gram-positive cocci
    Patrice Courvalin
    Unite des Agents Antibacteriens, Institut Pasteur, Paris, France
    Clin Infect Dis 42:S25-34. 2006
    ..The diversity, regulation, evolution, and recent dissemination of methicillin-resistant Staphylococcus aureus are then discussed...
  4. ncbi SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 24:362-86. 2003
    ..After 2 more years without improvement, a SHEA task force was appointed to draft this evidence-based guideline on preventing nosocomial transmission of such pathogens, focusing on the two considered most out of control: MRSA and VRE...
  5. pmc Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 46:1492-502. 2002
    ..These findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through the development of vancomycin tolerance...
  6. pmc Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300
    Susana Gardete
    Laboratory of Microbiology, The Rockefeller University, New York, New York, USA
    PLoS Pathog 8:e1002505. 2012
    ..as an on/off switch: mutation in yvqF in strain SG-R turns on the vraSR system, which leads to increase in vancomycin resistance and down-regulation of virulence determinants...
  7. ncbi Role of environmental contamination as a risk factor for acquisition of vancomycin-resistant enterococci in patients treated in a medical intensive care unit
    Jose A Martinez
    Division of Geographic Medicine and Infectious Disease and Clinical Care Research, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Arch Intern Med 163:1905-12. 2003
    ..However, the role of rooms with contaminated environmental surfaces has not been well delineated...
  8. pmc D-Ala-d-Ser VanN-type transferable vancomycin resistance in Enterococcus faecium
    Francois Lebreton
    Interactions Hôte et Microorganismes des Epithéliums, EA2128, CHU Cote de Nacre, 14033 Caen Cedex, France
    Antimicrob Agents Chemother 55:4606-12. 2011
    ..VanN-type resistance was transferable by conjugation to E. faecium. This is the first report of transferable d-Ala-d-Ser-type resistance in E. faecium...
  9. ncbi Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene
    Soju Chang
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta 30333, USA
    N Engl J Med 348:1342-7. 2003
  10. pmc Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus
    Michael Meehl
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Antimicrob Agents Chemother 51:2679-89. 2007
    ..encoding an ATP-binding cassette (ABC) transporter; but the exact contribution of these genes to increased vancomycin resistance has not been defined...
  11. ncbi Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia
    Alex Soriano
    Department of Infectious Diseases, Hospital Clinic of Barcelona, Barcelona, Spain
    Clin Infect Dis 46:193-200. 2008
    ..The aim of our study was to evaluate whether vancomycin minimum inhibitory concentration has any influence on the mortality associated with MRSA bacteremia...
  12. pmc Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance
    Hui min Neoh
    Department of Bacteriology, Faculty of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan 113 8421
    Antimicrob Agents Chemother 52:45-53. 2008
    ..alteration is required for methicillin-resistant Staphylococcus aureus (MRSA) to achieve the level of vancomycin resistance of vancomycin-intermediate S. aureus (VISA)...
  13. pmc Ability of Candida albicans mutants to induce Staphylococcus aureus vancomycin resistance during polymicrobial biofilm formation
    Melphine M Harriott
    Department of Medicine, Division of Infectious Diseases, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Antimicrob Agents Chemother 54:3746-55. 2010
    ..However, only mutants that could adhere to the abiotic surface could induce S. aureus vancomycin resistance, regardless of the presence of hyphae...
  14. pmc Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus
    Longzhu Cui
    Department of Bacteriology, Faculty of Medicine, Juntendo University, Bunkyo ku, Tokyo 113 8421, Japan
    J Clin Microbiol 41:5-14. 2003
    We have previously shown that a thickened cell wall is responsible for the vancomycin resistance of vancomycin-resistant Staphylococcus aureus (VRSA) (equivalent to vancomycin-intermediate S. aureus and glycopeptide-intermediate S...
  15. ncbi High rate of false-negative results of the rectal swab culture method in detection of gastrointestinal colonization with vancomycin-resistant enterococci
    Erika M C D'Agata
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Infect Dis 34:167-72. 2002
    ..001). Antibiotic exposure was significantly associated with higher VRE stool densities (P<.001). The high false-negative rate of the RS may be contributing to the continued increase in the prevalence of VRE...
  16. ncbi Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus
    Linda M Weigel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 302:1569-71. 2003
    ..Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S...
  17. pmc Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus
    Longzhu Cui
    Department of Bacteriology, Faculty of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Antimicrob Agents Chemother 50:428-38. 2006
    ..a common feature of VISA, and we have proposed that a thickened cell wall is a phenotypic determinant for vancomycin resistance in VISA (L. Cui, X. Ma, K. Sato, et al., J. Clin. Microbiol. 41:5-14, 2003)...
  18. ncbi Development of reduced vancomycin susceptibility in methicillin-susceptible Staphylococcus aureus
    Satish K Pillai
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Infect Dis 49:1169-74. 2009
    ..aureus (MSSA) clinical isolates. This isogenic series permitted us to determine whether the evolution of reduced vancomycin susceptibility in MSSA is similar to that seen in MRSA...
  19. pmc Heterogeneous vancomycin-intermediate susceptibility phenotype in bloodstream methicillin-resistant Staphylococcus aureus isolates from an international cohort of patients with infective endocarditis: prevalence, genotype, and clinical significance
    In Gyu Bae
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Infect Dis 200:1355-66. 2009
    ..Using a multinational collection of isolates from methicillin-resistant S. aureus (MRSA) infective endocarditis (IE), we characterized patients with IE with and without hVISA, and we genotyped the infecting strains...
  20. ncbi Enterococcal infections & antimicrobial resistance
    Seema Sood
    Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Indian J Med Res 128:111-21. 2008
    ..Emergence of antimicrobial resistance, pathogenicity and virulence factors, current preventive, control and treatment modalities of severe enterococcal infections are also dealt with...
  21. pmc Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus
    Longzhu Cui
    Department of Bacteriology, Faculty of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan 113 8421
    Antimicrob Agents Chemother 50:1079-82. 2006
    We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA)...
  22. pmc Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL
    David A Boyd
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Antimicrob Agents Chemother 52:2667-72. 2008
    ..The vanL gene cluster was similar in organization to the vanC operon, but the VanT serine racemase was encoded by two separate genes, vanTm(L) (membrane binding) and vanTr(L) (racemase)...
  23. ncbi Vancomycin-resistant enterococci: why are they here, and where do they come from?
    M J Bonten
    Department of Internal Medicine and the Eijkman Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, The Netherlands
    Lancet Infect Dis 1:314-25. 2001
    ....
  24. pmc Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease
    Wafa N Al-Nassir
    Department of Infectious Diseases, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 10000 Euclid Avenue, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 52:2403-6. 2008
    ..New CDAD treatments are needed that are less likely to disrupt the intestinal microflora and promote overgrowth of healthcare-associated pathogens...
  25. pmc Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus
    K Sieradzki
    The Rockefeller University, New York, New York 10021, USA
    J Bacteriol 185:7103-10. 2003
    ..Some change in the structure and/or metabolism of teichoic acids appears to be an important component of the mechanism of decreased susceptibility to vancomycin in S. aureus...
  26. pmc Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus
    Longzhu Cui
    Department of Bacteriology, Faculty of Medicine, Juntendo University, Tokyo, Japan
    Antimicrob Agents Chemother 53:1231-4. 2009
    ..Using a combination of Mu50Omega whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated vraS and graR genes of Mu50 were engineered into Mu50Omega.
  27. ncbi Duration of colonization with vancomycin-resistant Enterococcus
    Karin E Byers
    University of Virginia Health System, Charlottesville 22908, USA
    Infect Control Hosp Epidemiol 23:207-11. 2002
    ..To determine the duration of colonization with vancomycin-resistant Enterococcus (VRE) and the adequacy of 3 consecutive negative cultures to determine clearance...
  28. pmc Detection of the van alphabet and identification of enterococci and staphylococci at the species level by multiplex PCR
    Florence Depardieu
    Unite des Agents Antibacteriens, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Clin Microbiol 42:5857-60. 2004
    ..This specific and sensitive technique allows detection of glycopeptide-resistant strains, in particular methicillin-resistant S. aureus, that may escape phenotype-based automated rapid methods...
  29. ncbi Transfer of vancomycin-resistant enterococci via health care worker hands
    Amy N Duckro
    Department of Internal Medicine, Section of Infectious Diseases, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Intern Med 165:302-7. 2005
    ..We sought to determine the frequency of VRE transmission from sites in the environment or on patients' intact skin to clean environmental or skin sites via contaminated hands of HCWs during routine care...
  30. ncbi Whole genome sequencing of meticillin-resistant Staphylococcus aureus
    M Kuroda
    Hiramatsu, Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
    Lancet 357:1225-40. 2001
    ..N315 is a meticillin-resistant S aureus (MRSA) strain isolated in 1982, and Mu50 is an MRSA strain with vancomycin resistance isolated in 1997...
  31. ncbi Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology
    Paola Bisicchia
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Mol Microbiol 81:157-78. 2011
    The vancomycin resistance operons from Enterococci, Staphylococci and Actinomycetes encode a VanRS two-component signal transduction system (TCS) and a suite of enzymes to modify the peptidoglycan biosynthetic precursor lipid II and to ..
  32. ncbi Vancomycin resistance: occurrence, mechanisms and strategies to combat it
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Expert Opin Ther Targets 7:311-28. 2003
    ..However, vancomycin resistance has emerged, first in enterococci and, more recently, in Staphylococcus aureus...
  33. ncbi A mathematical model investigating the impact of an environmental reservoir on the prevalence and control of vancomycin-resistant enterococci
    Emma S McBryde
    J Infect Dis 193:1473-4. 2006
  34. pmc Microarray transcription analysis of clinical Staphylococcus aureus isolates resistant to vancomycin
    Emmanuel Mongodin
    Department of Medicine, Medical College of Virginia at Virginia Commonwealth University and the Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA
    J Bacteriol 185:4638-43. 2003
    ..We hypothesize that increased energy (ATP) is required to generate the thicker cell walls that characterize resistant mutants...
  35. pmc Acquisition and duration of vancomycin-resistant enterococcal carriage in relation to strain type
    E M Mascini
    Department of Hospital Hygiene and Infection Prevention, Eijkman Winkler Centre for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Microbiol 41:5377-83. 2003
    ..The results support a careful restrictive antibiotic policy for wards at risk for spread of VREF and implementation of isolation precautions for patients who are colonized with esp-positive outbreak strains...
  36. pmc Agricultural antibiotics and human health
    David L Smith
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Med 2:e232. 2005
  37. pmc Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures
    P J Johnsen
    Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
    J Antimicrob Chemother 66:608-10. 2011
    ..faecium (GSEF) from yearly surveillance data on the occurrence of GREF in Danish poultry farm environments...
  38. ncbi Risk of acquiring antibiotic-resistant bacteria from prior room occupants
    Susan S Huang
    Departments of Medicine and Infection Control, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:1945-51. 2006
    ....
  39. pmc Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study
    Susan S Huang
    Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, 100 Theory, Ste 110, Irvine, CA 92697, USA
    Crit Care 15:R210. 2011
    ....
  40. ncbi Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315
    Toshiko Ohta
    Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennohdai, Tukuba, Ibaraki 305 8575, Japan
    DNA Res 11:51-6. 2004
    ..seemed to be functionally decisive for the Mu50-specific characters, the thickened cell wall and moderate vancomycin resistance. All of the diverse genes and the high quality sequence of Mu50 can be viewed at the web site (http://133...
  41. pmc Diversity of Tn1546 and its role in the dissemination of vancomycin-resistant enterococci in Portugal
    Carla Novais
    REQUIMTE, Laboratorio de Microbiologia, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 4050 Porto, Portugal
    Antimicrob Agents Chemother 52:1001-8. 2008
    ..Apparent Tn1546 heterogeneity among enterococci from human, animal, and environmental sources might reflect frequent genetic exchange events and evolution of particular widely disseminated genetic elements...
  42. ncbi A mathematical model quantifying the impact of antibiotic exposure and other interventions on the endemic prevalence of vancomycin-resistant enterococci
    Erika M C D'Agata
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 192:2004-11. 2005
    ..A model was developed to quantify the contribution of antibiotic exposure and of other modifiable factors to the dissemination of VRE in the hospital setting...
  43. ncbi Identification and characterization of a vancomycin-resistant Staphylococcus aureus isolated from Kolkata (South Asia)
    Biswajit Saha
    Microbiology Laboratory, Department of Physiology, University College of Science, Technology and Agriculture, University of Calcutta, Kolkata, India
    J Med Microbiol 57:72-9. 2008
    ..The VRSA isolate was also positive for mecA. Vancomycin resistance was successfully transferred from this VRSA donor to a vancomycin-sensitive recipient S...
  44. ncbi The impact of persistent gastrointestinal colonization on the transmission dynamics of vancomycin-resistant enterococci
    Erika M C D'Agata
    Department of Medicine, Division of Infectious Diseases, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Infect Dis 185:766-73. 2002
    ..Decreasing the duration of colonization, limiting hospital acquisition of VRE, and improving compliance with hand hygiene in the hemodialysis unit may decrease the rapidly rising rates of VRE in the patient population...
  45. ncbi Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus
    Alexey Ruzin
    Wyeth Research, Pearl River, NY 10965, USA
    Biochim Biophys Acta 1621:117-21. 2003
    ..This observation serves as a likely mechanism of the increased vancomycin susceptibility associated with mprF inactivation...
  46. pmc Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus
    Benjamin P Howden
    Department of Microbiology, Monash University, Wellington Rd, Clayton, Victoria, Australia
    Antimicrob Agents Chemother 52:3755-62. 2008
    ..vancomycin-susceptible parent strain with the graS allele from the VISA derivative resulted in increased vancomycin resistance at a level between those of the vancomycin-susceptible S...
  47. ncbi Phylogenetic analysis of vancomycin-resistant Enterococcus faecium genotypes associated with outbreaks or sporadic infections in Italy
    Maria Grazia Bonora
    Microbiology Section, Department of Pathology, University of Verona, Verona, Italy
    Microb Drug Resist 13:171-7. 2007
    ..The main, though not the sole, mechanism that has driven this evolution was confirmed to be linked to the presence of the esp gene...
  48. pmc Evaluation of current methods for detection of staphylococci with reduced susceptibility to glycopeptides
    T R Walsh
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Clin Microbiol 39:2439-44. 2001
    ..0 McF inoculum, six different media were assessed against a selection of SRSV (n = 48) and MRSA (n = 12). Brain heart infusion agar yielded the highest sensitivity and specificity values: 88 and 88%, respectively...
  49. pmc Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia
    Benjamin P Howden
    Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia
    BMC Microbiol 8:39. 2008
    Low-level vancomycin resistance in Staphylococcus aureus (vancomycin-intermediate S. aureus (VISA) and hetero-VISA [hVISA]) emerges during persistent infection and failed vancomycin therapy...
  50. ncbi Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance
    K Hiramatsu
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    Lancet Infect Dis 1:147-55. 2001
    ..aureus (VRSA) strains from USA, France, Korea, South Africa, and Brazil has confirmed that emergence of vancomycin resistance in S aureus is a global issue. A certain group of S...
  51. ncbi Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge
    M Cueto
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA
    J Nat Prod 64:1444-6. 2001
    ....
  52. pmc Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
    George Sakoulas
    Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 49:2687-92. 2005
    ..In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations...
  53. pmc Simple and reliable multiplex PCR assay for surveillance isolates of vancomycin-resistant enterococci
    R Kariyama
    Section of Infection Control, Okayama University Hospital, Okayama 700 8558, Japan
    J Clin Microbiol 38:3092-5. 2000
    ..The PCR method developed in the present study is simple and reliable for the rapid characterization of vancomycin-resistant enterococci...
  54. pmc DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus
    Longzhu Cui
    Department of Bacteriology, Faculty of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 49:3404-13. 2005
    ..We propose that the genes which raise glycopeptide resistance in S. aureus function toward altering the cell wall metabolic pathway...
  55. ncbi Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
    I T Paulsen
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 299:2071-4. 2003
    ..The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci...
  56. pmc Inducible expression eliminates the fitness cost of vancomycin resistance in enterococci
    Marie Laure Foucault
    Unite des Agents Antibacteriens, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:16964-9. 2010
    Inducible vancomycin resistance in enterococci is due to a sophisticated mechanism that combines synthesis of cell wall peptidoglycan precursors with low affinity for glycopeptides and elimination of the normal target precursors...
  57. ncbi Antibiotic resistance of enterococci and related bacteria in an urban wastewater treatment plant
    Miguel Ferreira da Silva
    Escola Superior de Biotecnologia, Universidade Catolica Portuguesa, Porto, Portugal
    FEMS Microbiol Ecol 55:322-9. 2006
    ..faecalis remained the same in the raw and in the treated wastewater. Among the isolates tested, no vancomycin resistance was observed among the enterococci. Entercoccus faecium and E...
  58. ncbi A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital
    M Wootton
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Microbiology, North Bristol Health Trust and University of Bristol, Southmead Hospital, Westbury on Trym, Bristol, BS10 5NB, UK
    J Antimicrob Chemother 47:399-403. 2001
    ..The modified population analysis reliably detected vancomycin hetero-resistance in Mu 3 and identified no hVRSAs within the 100 MRSA sample...
  59. pmc VanA-type enterococci from humans, animals, and food: species distribution, population structure, Tn1546 typing and location, and virulence determinants
    F Biavasco
    Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, Via Ranieri, Monte D Ago, 60131 Ancona, Italy
    Appl Environ Microbiol 73:3307-19. 2007
    ....
  60. pmc Human and swine hosts share vancomycin-resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 clonal clusters harboring Tn1546 on indistinguishable plasmids
    Ana R Freitas
    REQUIMTE, Laboratorio de Microbiologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    J Clin Microbiol 49:925-31. 2011
    ..The results indicate a current intra- and international spread of E. faecium and E. faecalis clones and their plasmids among swine and humans...
  61. pmc Vancomycin resistance in staphylococci
    Arjun Srinivasan
    Division of Infectious Diseases, Department of Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Microbiol Rev 15:430-8. 2002
    b>Vancomycin resistance has been reported in clinical isolates of both coagulase-negative staphylococci and Staphylococcus aureus...
  62. pmc Role of VraSR in antibiotic resistance and antibiotic-induced stress response in Staphylococcus aureus
    S Gardete
    Molecular Genetics Laboratory, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Oeiras, Portugal
    Antimicrob Agents Chemother 50:3424-34. 2006
    ..One of the sites in cell wall synthesis "sensed" by the VraSR system appears to be a step catalyzed by PBP 2...
  63. pmc Characterizing an outbreak of vancomycin-resistant enterococci using hidden Markov models
    E S McBryde
    School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    J R Soc Interface 4:745-54. 2007
    ..Genotyping is commonly used to distinguish epidemic from sporadic vancomycin-resistant enterococci (VRE). We compare this to a statistical method to determine the transmission characteristics of VRE...
  64. pmc Vancomycin MIC plus heteroresistance and outcome of methicillin-resistant Staphylococcus aureus bacteremia: trends over 11 years
    Adina C Musta
    Department of Medicine, Infectious Diseases, St John Hospital and Medical Center, Detroit, MI, USA
    J Clin Microbiol 47:1640-4. 2009
    ..A multicenter prospective randomized study by the use of standardized methods is needed to evaluate the relevance of hVISA and determine the optimal treatment of patients whose isolates have V-MICs of > or = 2.0 microg/ml...
  65. ncbi Occurrence and spread of antibiotic resistances in Enterococcus faecium
    Ingo Klare
    Robert Koch Institute, Wernigerode Branch, Burgstrasse 37, D 38855 Wernigerode, Germany
    Int J Food Microbiol 88:269-90. 2003
    ..In order to prevent the dissemination of multiple antibiotic-resistant enterococci or their transferable resistance genes, a prudent use of antibiotics is necessary in human and veterinary medicine, and in animal husbandry...
  66. ncbi Vancomycin-resistant Staphylococcus aureus in the United States, 2002-2006
    Dawn M Sievert
    Michigan Department of Community Health, Lansing, USA
    Clin Infect Dis 46:668-74. 2008
    ....
  67. pmc Emergence of vancomycin-resistant enterococci
    L B Rice
    VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Emerg Infect Dis 7:183-7. 2001
    ..Control of VRE will require better understanding of the mechanisms by which different classes of drugs promote gastrointestinal colonization...
  68. ncbi A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203
    Paul D R Johnson
    Department of Infectious Diseases and Microbiology, Austin Health, Monash University, Melbourne, Victoria, Australia
    J Infect Dis 202:1278-86. 2010
    ..A significant increase in the rate of vancomycin-resistant Enterococcus faecium (VREfm) bacteremia at our health service, despite improved infection control, prompted us to investigate the cause...
  69. pmc walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus
    Mitsutaka Shoji
    Department of Infection Control Science, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 55:3870-81. 2011
    ..and yycFG), and a truncating mutation in a proteolytic regulatory gene, clpP, responsible for the raised vancomycin resistance in a laboratory-derived VISA strain, LR5P1-V3...
  70. ncbi Determinants of vancomycin resistance and mortality rates in enterococcal bacteremia. a prospective multicenter study
    E N Vergis
    Division of Infectious Diseases, University of Pittsburgh, Suite 3A, Falk Medical Building, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Ann Intern Med 135:484-92. 2001
    BACKGROUND: Enterococcus species are major nosocomial pathogens and are exhibiting vancomycin resistance with increasing frequency...
  71. pmc Antecedent treatment with different antibiotic agents as a risk factor for vancomycin-resistant Enterococcus
    Yehuda Carmeli
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Emerg Infect Dis 8:802-7. 2002
    ..Vancomycin was not a risk factor for isolation of VRE...
  72. ncbi Reduction in acquisition of vancomycin-resistant enterococcus after enforcement of routine environmental cleaning measures
    Mary K Hayden
    Dept of Medicine and Pathology, Rush University Medical Center, Chicago, IL 60612, USA
    Clin Infect Dis 42:1552-60. 2006
    ..Using vancomycin-resistant enterococci (VRE) as a marker organism, we investigated the effects of improved environmental cleaning with and without promotion of hand hygiene adherence on the spread of VRE in a medical intensive care unit...
  73. ncbi The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus
    P C Appelbaum
    Hershey Medical Center, Hershey, Pennsylvania, USA
    Clin Microbiol Infect 12:16-23. 2006
    ..Although the mechanisms underlying vancomycin resistance are not yet fully understood, changes to the bacterial cell wall-the site of action of the glycopeptides-..
  74. ncbi Clinical features of heteroresistant vancomycin-intermediate Staphylococcus aureus bacteremia versus those of methicillin-resistant S. aureus bacteremia
    Yasmin Maor
    Infectious Diseases Unit, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
    J Infect Dis 199:619-24. 2009
    ..Our objective was to compare patients who had hVISA bacteremia with patients who had methicillin-resistant S. aureus (MRSA) bacteremia...
  75. ncbi Twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce?
    Vincent Cattoir
    Equipe EA4655 Risques Microbiens, Faculté de Médecine de Caen, Université Caen Basse Normandie, Caen, France
    J Antimicrob Chemother 68:731-42. 2013
    ..Although so far unsuccessful, dissemination of glycopeptide-resistant Staphylococcus aureus with van genes acquired from resistant enterococci cannot be ruled out...
  76. ncbi Presence of the resistance genes vanC1 and pbp5 in phenotypically vancomycin and ampicillin susceptible Enterococcus faecalis
    Karin Schwaiger
    Technische Universitat Munchen, Freising Weihenstephan, Germany
    Microb Drug Resist 18:434-9. 2012
    ..faecalis have a strong ability to acquire resistance genes-and potentially to spread them to other bacteria. Therefore, close monitoring of this species should be continued...
  77. ncbi Prospective, multicenter evaluation of the BD GeneOhm VanR assay for direct, rapid detection of vancomycin-resistant Enterococcus species in perianal and rectal specimens
    Elena A Usacheva
    Microbiology and Infectious Diseases Research, NorthShore University Healthsystem, Evanston, IL 60201 1781, USA
    Am J Clin Pathol 134:219-26. 2010
    ..Samples positive for the vanB genotype should be confirmed by culture owing to the apparent high number of false-positive results...
  78. pmc Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin
    Jae Hoon Song
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
    Antimicrob Agents Chemother 48:4926-8. 2004
    ..However, neither vancomycin-intermediate S. aureus nor vancomycin-resistant S. aureus isolates were found among MRSA isolates from Asian countries in this survey...
  79. ncbi Effective suppression of vancomycin-resistant Enterococcus species in asymptomatic gastrointestinal carriers by a novel glycolipodepsipeptide, ramoplanin
    M T Wong
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Infect Dis 33:1476-82. 2001
    ..By day 21, there were no differences between treatment groups. Adverse events were similar for all treatment groups. Ramoplanin was safe and effective in temporarily suppressing gastrointestinal VRE carriage...
  80. pmc Vancomycin-resistant enterococci outbreak, Germany, and calculation of outbreak start
    Ulrich Sagel
    analyse BioLab GmbH, Linz, Austria
    Emerg Infect Dis 14:317-9. 2008
    ..For this purpose, we demonstrate an easy-to-use statistical method...
  81. ncbi Vancomycin-resistant enterococci from Portuguese wastewater treatment plants
    Carlos Araújo
    Centre of Studies of Animal and Veterinary Sciences, Vila Real, Portugal
    J Basic Microbiol 50:605-9. 2010
    ..faecium isolate. This study suggests that the wastewater treatment plants might be an important source of dissemination of antibiotic-resistant enterococci in Portugal...
  82. ncbi Molecular epidemiology of urinary tract isolates of vancomycin-resistant Enterococcus faecium from North America
    Kimberly A Nichol
    Department of Clinical Microbiology, Health Sciences Centre, MS673 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9
    Int J Antimicrob Agents 27:392-6. 2006
    ..This suggests that the spread of VRE within North America is a complex process involving both the horizontal transfer of glycopeptide resistance determinants and polyclonal dissemination...
  83. pmc Transfer of vancomycin resistance transposon Tn1549 from Clostridium symbiosum to Enterococcus spp. in the gut of gnotobiotic mice
    Aline Launay
    Centre d Etudes Pharmaceutiques, Chatenay Malabry, France
    Antimicrob Agents Chemother 50:1054-62. 2006
    The vancomycin resistance vanB2 gene cluster is disseminated worldwide and has been found in phylogenetically remote bacterial genera...
  84. ncbi Novel vancomycin-resistance transposon, plasmid replicon types, and virulence factors of vancomycin-resistant Enterococci in Zhejiang, China
    Ting Ting Qu
    State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Microb Drug Resist 18:183-8. 2012
    ..types (pRUM, pRE25, pEF418, and pB82) were more common in VRE isolates, suggesting their association with vancomycin resistance and nosocomial transmission...
  85. pmc Incidence of and risk factors for infection or colonization of vancomycin-resistant enterococci in patients in the intensive care unit
    Sung Ching Pan
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 7:e47297. 2012
    ..Strategies to reduce the duration of ICU stay and prudent usage of broad-spectrum antibiotics are the keys to controlling VRE transmission...
  86. ncbi Analysis of VanA vancomycin-resistant Enterococcus faecium isolates from Saudi Arabian hospitals reveals the presence of clonal cluster 17 and two new Tn1546 lineage types
    Mushtaq A Khan
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, s Gravendijkwal 230, 3015CE Rotterdam, The Netherlands
    J Antimicrob Chemother 62:279-83. 2008
    ..The aim of this study was to characterize 34 vancomycin-resistant VanA Enterococcus faecium isolates obtained from two hospitals in Saudi Arabia and to assess Tn1546 variation within these isolates...
  87. ncbi Projected benefits of active surveillance for vancomycin-resistant enterococci in intensive care units
    Eli N Perencevich
    Veterans Affairs Maryland Healthcare System, Baltimore, Maryland, USA
    Clin Infect Dis 38:1108-15. 2004
    ..Passive surveillance was minimally effective. Using the best available data, active surveillance is projected to be effective for reducing VRE transmission in ICU settings...
  88. ncbi A potential virulence gene, hylEfm, predominates in Enterococcus faecium of clinical origin
    Louis B Rice
    Research and Medical Services, Louis Stokes Cleveland Veterans Affairs Medical Center and Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 187:508-12. 2003
    ..Differences in the prevalence of these strains may help explain variations in the clinical importance of multiresistant E. faecium across different continents...
  89. pmc Risk factors for new detection of vancomycin-resistant enterococci in acute-care hospitals that employ strict infection control procedures
    Alexander A Padiglione
    Department of Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia
    Antimicrob Agents Chemother 47:2492-8. 2003
    ....
  90. ncbi Risk of vancomycin-resistant Enterococcus (VRE) bloodstream infection among patients colonized with VRE
    Chamion N Olivier
    Medical University of South Carolina, Charleston, SC 29425, USA
    Infect Control Hosp Epidemiol 29:404-9. 2008
    ..We sought to determine the proportion of VRE-colonized patients who subsequently develop VRE BSI and to identify risk factors for VRE BSI among these patients...
  91. ncbi Effectiveness of universal screening for vancomycin-resistant enterococcus and methicillin-resistant Staphylococcus aureus on admission to a burn-trauma step-down unit
    Lucy Wibbenmeyer
    Department of Surgery, The University of Iowa Carver College of Medicine, The University of Iowa Hospitals and Clinics, Iowa City, IA 52246, USA
    J Burn Care Res 30:648-56. 2009
    ....
  92. pmc The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA)
    D I Roper
    York Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York YO10 5DD, United Kingdom
    Proc Natl Acad Sci U S A 97:8921-5. 2000
    ..The structure of d-alanyl-d-lactate ligase provides a revised interpretation of the molecular events that lead to vancomycin resistance.
  93. ncbi The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial
    Michael W Climo
    Hospital Epidemiologist MWC, Hunter Holmes McGuire Veteran Affairs Medical Center, Richmond, VA, USA
    Crit Care Med 37:1858-65. 2009
    ....
  94. ncbi Vancomycin-resistant enterococci (VRE): transmission and control
    Evelina Tacconelli
    Division Infectious Diseases, Catholic University, Largo F Vito, 100168, Rome, Italy
    Int J Antimicrob Agents 31:99-106. 2008
    ..Future prospective comparative studies of infection control approaches in different epidemiological situations might be useful...
  95. ncbi Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002
    S K Bouchillon
    Laboratories International for Microbiology Studies, 2122 Palmer Road, Schaumburg, IL 60173 3817, USA
    Int J Antimicrob Agents 24:119-24. 2004
    ..4% (294/908) and 8.7% (83/949), respectively. PEARLS provides baseline data against which prospective changes in resistant determinants and outcomes can be measured in this ongoing study...
  96. pmc Vancomycin-intermediate Staphylococcus aureus in a home health-care patient
    J C Hageman
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 7:1023-5. 2001
    ..The patient was treated successfully with antimicrobial therapy, biliary drainage, and reconstruction. Standard precautions in the home health setting appear successful in preventing transmission...
  97. pmc Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus
    Wenming Zhu
    Division of Healthcare Quality Promotion1 and Division of Scientific Resources, 4 Centers for Disease Control and Prevention, MS G08, 1600 Clifton Road, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 54:4314-20. 2010
    ..Although VRE isolates with the VRSA-associated Inc18-like vanA plasmid were more common in Michigan, they remain rare. Periodic surveillance of VRE isolates for the plasmid may be useful in predicting the occurrence of VRSA...
  98. ncbi Laboratory-based surveillance for vancomycin-resistant enterococci: utility of screening stool specimens submitted for Clostridium difficile toxin assay
    A L Leber
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, USA
    Infect Control Hosp Epidemiol 22:160-4. 2001
    ..Such a laboratory-based surveillance should be included as part of a comprehensive program to limit nosocomial VRE transmission...
  99. ncbi Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitals
    I Klare
    Robert Koch Institute, Wernigerode Branch, Burgstr 37, 38855, Wernigerode, Germany
    Eur J Clin Microbiol Infect Dis 24:815-25. 2005
    ..In conclusion, it is very important to monitor the occurrence of epidemic-virulent clonal complex-17 strains of E. faecium to prevent their spread in hospitals, especially if they are resistant to glycopeptides and linezolid...
  100. ncbi Vancomycin-resistant enterococci: mechanisms and clinical observations
    H S Gold
    Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Clin Infect Dis 33:210-9. 2001
    ..This article seeks to concisely review the mechanisms of that resistance and its effects on clinical management of enterococcal infections, as well as clinical microbiology and infection control...
  101. ncbi Reduced glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA)
    Peter C Appelbaum
    Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Int J Antimicrob Agents 30:398-408. 2007
    ..Rapid identification of patients harbouring VRSA, VISA or hVISA as well as prompt isolation and adherence to infection control protocols are paramount in controlling the dissemination of these pathogens...

Research Grants61

  1. Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faecium
    Louis B Rice; Fiscal Year: 2013
    ..have also identified and characterized an L,D-transpeptidase (Ldtfm) that is able to confer ?-lactam and vancomycin resistance in the absence of Pbp5, in concert with the activity of a D,D-carboxypeptidase...
  2. Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMR
    Jacob Schaefer; Fiscal Year: 2013
    ....
  3. 3rd ASM Conference on Enterococci
    Don B Clewell; Fiscal Year: 2010
    ..Indeed there is evidence that the recent emergence of high-level vancomycin resistance in Staphylococcus aureus (MRSA) strains is likely a result of acquisition of related determinant(s) from ..
  4. Biofilms and Enterococcus faecalis Biology
    Gary M Dunny; Fiscal Year: 2013
    ..The biofilm environment is a likely niche for transfer of high-level vancomycin resistance from enterococci to Staphylococcus aureus...
  5. Defining Precursors to VRSA Emergence: Epidemiology of MRSA &VRE Dual Infection
    Emily Toth Martin; Fiscal Year: 2013
    ..most at risk of VRSA infection through characterization of molecular elements that drive the emergence of vancomycin resistance in clinical VRE and MRSA isolates...
  6. Polymicrobial dynamics in transfer of vancomycin resistance to MRSA
    Matthew Ramsey; Fiscal Year: 2013
    ..Since 2002, VanA-type vancomycin resistance has moved on plasmids from vancomycin resistant enterococci (VRE) to MRSA, forming VRSA...
  7. Harvard-wide Program on Antibiotic Resistance
    Suzanne Walker; Fiscal Year: 2013
    ..This has become urgent with the introduction of vancomycin resistance from VRE (leading causes of multidrug resistant hospital infection)...
  8. BIOLOGICALLY ACTIVE CYCLIC PEPTIDES
    Dale L Boger; Fiscal Year: 2013
    ..vancomycin to bind D-Ala-D-Lac, may provide several unique approaches to countering the emerging vancomycin resistance, and will provide a fundamental understanding of the structure-function relationships of the glycopeptide ..
  9. Antibiotic resistant genes and resistant phenotypes in MRSA and VISA strains
    Alexander Tomasz; Fiscal Year: 2013
    ..Similarly, genetic determinants associated with the acquisition of VISA type vancomycin resistance has been determined recently by full genome sequencing but the mechanism by which the increased vancomycin ..
  10. STAPHYLOCOCCAL VANCOMYCIN AND METHICILLIN RESISTANCE
    BRIAN WILKINSON; Fiscal Year: 2001
    ..aureus or GISA strains). It is imperative that we understand the mechanism of vancomycin resistance in such strains. Vancomycin-resistant strains have been step-selected in the investigators laboratory...
  11. ACTIVATION OF VANS IN VITRO
    Bernard Weisblum; Fiscal Year: 2000
    The long-term objective of this proposal is to study the process of induced VanA-type vancomycin resistance in the opportunist Enterococcus faecium and to learn the sequence of events leading from exposure of cells to vancomycin to the ..
  12. GENOME ANALYSIS OF STAPHYLOCOCCUS AUREUS
    Steven Gill; Fiscal Year: 1999
    ..aureus infections. However, two documented cases of vancomycin resistance in 1997 may signal the emergence of S. a aureus strains with compete resistance to vancomycin...
  13. GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASES
    Henry Chambers; Fiscal Year: 1999
    ..aureus autolysins, therapeutics, vancomycin resistance, methicillin resistance, genomics, gene regulation, immunity and vaccine development...
  14. BIOORGANIC CHEMISTRY OF ANTIBACTERIALS
    Michael Pirrung; Fiscal Year: 2001
    ..of the microbial histidine-aspartate kinase two-component signaling system that is responsible for vancomycin resistance; discovery of inhibitors of a metallopeptidase involved in lipid A biosynthesis; discovery of inhibitors ..
  15. Physiology of S aureus Vancomycin Resistance
    BRIAN WILKINSON; Fiscal Year: 2001
    ..aureus or GISA strains). It is imperative that we understand the mechanism of vancomycin resistance in such strains. Vancomycin-resistant strains have been step selected in my laboratory...
  16. Antibodies to Overcome Antibiotic Resistance
    Arup Sen; Fiscal Year: 2001
    ..Novel catalytic antibodies will be created to target the molecular basis of vancomycin resistance development...
  17. NOVEL ANTIBIOTICS FOR VANCOMYCIN RESISTANT INFECTION
    Kit Lam; Fiscal Year: 1999
    ..We further hypothesize that an antibiotic that can overcome vancomycin resistance can be discovered by screening combinatorial libraries with a D-Alan-D-Lactate probe...
  18. D AMINOACID LIGASES AND BACTERIAL VANCOMYCIN RESISTANCE
    James Knox; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Because of the increased appearance of vancomycin resistance in methicillin-resistant Staphylococcus aureus, and its consequences to hospital patients, it is of vital importance to ..
  19. STRUCTURE-BASED ANTIMICROBIAL DESIGN
    PAUL AXELSEN; Fiscal Year: 2004
    ..The overall aim is to confront the emerging health threat of vancomycin-resistance by facilitating the rational design of drugs, and gain insight into the physico-chemical basis of specific molecular recognition. ..
  20. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
    ..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
  21. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  22. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  23. Transmission Dynamics of Antimocrobial-resistant bacteria in dialysis units
    ERIKA D AGATA; Fiscal Year: 2007
    ..Limiting ARB spread will ultimately reduce infections caused by ARB and improve CHD patient outcomes. [unreadable] [unreadable] [unreadable]..
  24. Enterococcus faecium virulence: A molecular and therapeutic approach
    Cesar Arias; Fiscal Year: 2008
    ..A translational approach using the mentor's laboratory established animal models (mouse peritonitis and rat infective endocarditis) will be utilized to explore therapeutic approaches. [unreadable] [unreadable] [unreadable]..
  25. Nisin-based topical formulation for treatment of anthrax
    John Kokai Kun; Fiscal Year: 2003
    ..The final product is intended to minimize the danger for those exposed to B. anthracis and should also be effective for disinfection of other bioterrorism agents and for nosocomial pathogens in the healthcare setting. ..
  26. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
  27. Device use in Nursing Homes: Reducing Risk of Infection
    Lona Mody; Fiscal Year: 2007
    ..abstract_text> ..
  28. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  29. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  30. Hospital-Acquired Infections in the Elderly
    Keith Kaye; Fiscal Year: 2008
    ..The risk factor identified for SSI and MDRB and the impact of SSI and MDRB on health outcomes will be used to design and implement future preventive interventions. ..
  31. MULTIPLE ANTIBIOTIC RESISTANCE (MAR) REGULON
    Stuart Levy; Fiscal Year: 2001
    ....
  32. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  33. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  34. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  35. Reducing Antimicrobial Use Associated with Ventilator Associated Pneumonia and Ca
    SARA ELIZABETH COSGROVE; Fiscal Year: 2010
    ..We hypothesize that this approach will enhance appropriate use of antimicrobials for both VAP and CAUTI and improve patient outcomes by reducing the known sequelae of antimicrobial overuse. ..
  36. METALLO BETA LACTAMASE FROM X MALTOPHILIA
    Michael Crowder; Fiscal Year: 2002
    ....
  37. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  38. Zn(II) metallochaperones in E. coli
    Michael Crowder; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  40. REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMA
    Joseph Solomkin; Fiscal Year: 2004
    ..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
  41. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  42. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  43. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  44. Staff Hand Hygiene and Nosocomial Infections in Neonates
    Elaine Larson; Fiscal Year: 2003
    ....
  45. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2004
    ....
  46. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
    ..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
  47. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  48. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  49. Chemokines and microglia in Alzheimer's disease
    Joseph El Khoury; Fiscal Year: 2005
    ....
  50. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2006
    ..Such understanding will also enhance[unreadable] efforts to reverse efflux of other antibiotics and drugs used to treat infectious diseases, including[unreadable] bacteria, fungi and parasites, and cancer. ..
  51. EXPERIMENTAL PATHOGENESIS & THERAPY OF OCULAR ADENOVIRUS
    Y Gordon; Fiscal Year: 2006
    ..Furthermore, a better understanding of antiviral resistance and the innate immune host defenses will enable us to optimize our therapeutic options against this significant ocular pathogen. ..
  52. Interdisciplinary Research:Antimicrobial Resistance(RMI)
    Elaine Larson; Fiscal Year: 2006
    ..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
  53. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  54. Genome Sequencing of Toxoplasma gondii
    Ian Paulsen; Fiscal Year: 2002
    ..gondii research community is solidly behind this effort, and the history of this group (in supporting and successfully exploiting the T. gondii EST project, for example) bodes well for successful utilization of the genomic sequence...
  55. Modeling, Estimation and Control in HIV Dynamics
    H Banks; Fiscal Year: 2005
    ....
  56. HOME HYGIENE INTERVENTION
    Elaine Larson; Fiscal Year: 2002
    ..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
  57. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  59. Intra-species regulatory functions of fsr
    Satish Pillai; Fiscal Year: 2004
    ..abstract_text> ..
  60. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..