methicillin resistance

Summary

Summary: Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.

Top Publications

  1. ncbi Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    R Monina Klevens
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    JAMA 298:1763-71. 2007
  2. pmc Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
    J Clin Microbiol 38:1008-15. 2000
  3. pmc Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management
    Dag Harmsen
    Institute for Hygiene, University of Munster, Munster, Germany
    J Clin Microbiol 41:5442-8. 2003
  4. pmc Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions
    Yoko Kondo
    Department of Infection Control Science, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 51:264-74. 2007
  5. ncbi Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus
    Binh An Diep
    Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94143, USA
    Lancet 367:731-9. 2006
  6. pmc Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005
    Eili Klein
    Resources for the Future, Washington DC, USA
    Emerg Infect Dis 13:1840-6. 2007
  7. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
  8. ncbi Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection
    Timothy S Naimi
    Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
    JAMA 290:2976-84. 2003
  9. pmc Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus
    Catarina Milheiriço
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    Antimicrob Agents Chemother 51:3374-7. 2007
  10. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006

Detail Information

Publications325 found, 100 shown here

  1. ncbi Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    R Monina Klevens
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    JAMA 298:1763-71. 2007
    ..As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed...
  2. pmc Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
    J Clin Microbiol 38:1008-15. 2000
    ..MLST provides an unambiguous method for assigning MRSA and MSSA isolates to known clones or assigning them as novel clones via the Internet...
  3. pmc Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management
    Dag Harmsen
    Institute for Hygiene, University of Munster, Munster, Germany
    J Clin Microbiol 41:5442-8. 2003
    ..spa typing was valuable for tracking of epidemic isolates. The data show that disproval of epidemiologically suggested transmissions of MRSA is one of the main objectives of spa typing in departments with a high incidence of MRSA...
  4. pmc Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions
    Yoko Kondo
    Department of Infection Control Science, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 51:264-74. 2007
    ..The SCCmec type assignments were identical to those made with a PCR system that uses numerous primer pairs to identify genes or gene alleles. Our system of six M-PCRs is thus a convenient and reliable method for typing SCCmec elements...
  5. ncbi Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus
    Binh An Diep
    Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94143, USA
    Lancet 367:731-9. 2006
    ..Our aim was to sequence its genome and compare it with those of other strains of S aureus to try to identify genes responsible for its distinctive epidemiological and virulence properties...
  6. pmc Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005
    Eili Klein
    Resources for the Future, Washington DC, USA
    Emerg Infect Dis 13:1840-6. 2007
    ..Our findings suggest that S. aureus and MRSA should be considered a national priority for disease control...
  7. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
    ..While spa-type t108 is apparently a more widespread clone among pig farmers and their environment, we did find other spa-types...
  8. ncbi Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection
    Timothy S Naimi
    Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
    JAMA 290:2976-84. 2003
    ..However, MRSA has emerged in patients without established risk factors (community-associated MRSA)...
  9. pmc Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus
    Catarina Milheiriço
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    Antimicrob Agents Chemother 51:3374-7. 2007
    ..Here, we describe an update to the multiplex PCR strategy for SCCmec typing that we described in 2002 so that SCCmec types IV and V may be properly identified...
  10. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006
    ..Whether community-associated methicillin-resistant Staphylococcus aureus (MRSA) genotypes (e.g., USA300) are a major cause of bloodstream infections (BSIs) and health care-associated infections has been poorly defined...
  11. ncbi Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillanc
    D J Diekema
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Clin Infect Dis 32:S114-32. 2001
    ..Rates of methicillin resistance were extremely high among S. aureus isolates from centers in Hong Kong and Japan...
  12. ncbi Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
    ..54-2.42; P<.001); significant heterogeneity was present. We explored the reasons for heterogeneity by means of subgroup analyses. MRSA bacteremia is associated with significantly higher mortality rate than is MSSA bacteremia...
  13. ncbi Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 194:1761-70. 2006
    ..Although the toxin may be a highly linked epidemiological marker for CA-MRSA strains, we conclude that PVL is not the major virulence determinant of CA-MRSA...
  14. ncbi Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat
    Hajo Grundmann
    Centre for Infectious Diseases Epidemiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Lancet 368:874-85. 2006
    ....
  15. pmc Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: a single approach developed by consensus in 10 European laboratories and its application for tracing the spre
    Stephen Murchan
    Laboratory of Hospital Infection, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    J Clin Microbiol 41:1574-85. 2003
    ..This highlights the need for closer international collaboration to monitor the spread of current epidemic strains as well as the emergence of new ones...
  16. ncbi Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers
    T Khanna
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Vet Microbiol 128:298-303. 2008
    ..This study demonstrates that MRSA is common in pigs in Ontario, Canada, and provides further support to concerns about transmission of MRSA between pigs and humans...
  17. ncbi Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study
    M W H Wulf
    Department of Medical Microbiology, Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Microbiol Infect 14:29-34. 2008
    ....
  18. ncbi Staphylococcus aureus endocarditis: a consequence of medical progress
    Vance G Fowler
    Duke University Medical Center, Durham, NC 27710, USA
    JAMA 293:3012-21. 2005
    ..The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown...
  19. ncbi Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 36:592-8. 2003
    Data for 479 patients were analyzed to assess the impact of methicillin resistance on the outcomes of patients with Staphylococcus aureus surgical site infections (SSIs). Patients infected with methicillin-resistant S...
  20. ncbi Whole genome sequencing of meticillin-resistant Staphylococcus aureus
    M Kuroda
    Hiramatsu, Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
    Lancet 357:1225-40. 2001
    ..Investigation of many newly identified gene products, including the 70 putative virulence factors, will greatly improve our understanding of the biology of staphylococci and the processes of infectious diseases caused by S aureus...
  21. pmc Diversity of SCCmec elements in methicillin-resistant coagulase-negative staphylococci clinical isolates
    Zhiyong Zong
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
    PLoS ONE 6:e20191. 2011
    ..Characterization of SCCmec in MR-CoNS can generate useful information on the mobilization and evolution of this element...
  22. pmc Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system
    Justine K Rudkin
    Department of Biology and Biochemistry, University of Bath, UK
    J Infect Dis 205:798-806. 2012
    ..MRSA (HA-MRSA) clones, we show that expression of the gene responsible for conferring methicillin resistance (mecA) is also directly responsible for reducing the ability of HA-MRSA to secrete cytolytic toxins...
  23. ncbi The evolution of Staphylococcus aureus
    Ruud H Deurenberg
    Department of Medical Microbiology, University Hospital Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands
    Infect Genet Evol 8:747-63. 2008
    ..This review describes the latest observations about the structure of SCCmec, the techniques used to study the molecular epidemiology and evolution of S. aureus as well as some challenges that researchers face in the future...
  24. pmc Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence
    Francois Vandenesch
    INSERM E0230, Lyon, France
    Emerg Infect Dis 9:978-84. 2003
    ..Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA...
  25. ncbi Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'
    Catarina Milheiriço
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    J Antimicrob Chemother 60:42-8. 2007
    ..To develop and validate a new multiplex PCR strategy for subtyping SCCmec type IV methicillin-resistant Staphylococcus aureus (MRSA) strains-SCCmec IV multiplex PCR...
  26. pmc Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans
    Inge van Loo
    Elisabeth Hospital, Tilburg, The Netherlands
    Emerg Infect Dis 13:1834-9. 2007
    ..This study shows that MRSA from an animal reservoir has recently entered the human population and is now responsible for >20% of all MRSA in the Netherlands...
  27. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
    ..Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA...
  28. pmc Methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 in pigs and humans
    Alex van Belkum
    University Medical Center Rotterdam, Rotterdam, The Netherlands
    Emerg Infect Dis 14:479-83. 2008
    ..aureus circulates among humans at low frequency (0.2%) but was isolated in 3 human cases of bacteremia (2.1%; p = 0.026). Although its natural host is probably porcine, ST398 MRSA likely causes infections in humans...
  29. ncbi Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000-2006
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Infect Dis 198:336-43. 2008
    ..We sought to describe the epidemiological profile of S. aureus bacteremia and to assess whether the incidence and severity of and the antimicrobial resistance rates associated with this bacteremia are increasing...
  30. ncbi SCCmec in staphylococci: genes on the move
    Anne Merethe Hanssen
    Department of Microbiology and Virology, Institute of Medical Biology, University of Tromso, Tromso, Norway
    FEMS Immunol Med Microbiol 46:8-20. 2006
    ..cassette chromosome (SCC) elements are, so far, the only vectors described for the mecA gene encoding methicillin resistance in staphylococci...
  31. pmc Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infections
    Cynthia L Maree
    David Geffen School of Medicine, University of California, Los Angeles, California90509, USA
    Emerg Infect Dis 13:236-42. 2007
    ..In conclusion, MRSA isolates phenotypically similar to CA strains have become the predominant isolates associated with HA-MRSA in our hospital...
  32. ncbi SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 24:362-86. 2003
    ..After 2 more years without improvement, a SHEA task force was appointed to draft this evidence-based guideline on preventing nosocomial transmission of such pathogens, focusing on the two considered most out of control: MRSA and VRE...
  33. pmc Staphylococcus haemolyticus as an important hospital pathogen and carrier of methicillin resistance genes
    E M Barros
    Departamento de Microbiologia Medica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Clin Microbiol 50:166-8. 2012
    ..Approximately 55% harbored staphylococcal cassette chromosome mec element (SCCmec) type V, and only one SCCmec type IV. Many isolates (75%) displayed multiresistance, and pulsotype analysis showed a high diversity...
  34. pmc Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids
    Stephanie Brown
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:18909-14. 2012
    ..These data suggest β-O-GlcNAcylated WTAs scaffold factors required for MRSA resistance. The β-O-GlcNAc transferase identified here, TarS, is a unique target for antimicrobials that sensitize MRSA to β-lactams...
  35. ncbi Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey
    Stan Deresinski
    Division of Infectious Disease and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
    Clin Infect Dis 40:562-73. 2005
    ..This has led to an important change in the choice of antibiotics in the management of community-acquired infections and has also led to the development of novel antimicrobials...
  36. ncbi Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle
    Stefan Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine, Carl Gustav Carus at the Technical University of Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    Vet Microbiol 125:128-40. 2007
    ..The presence of these two strains highlights the possibility of transfers of S. aureus strains between different host species...
  37. ncbi The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: identification of two ancestral genetic backgrounds and the associated mec elements
    D C Oliveira
    Laboratory of Microbiology, The Rockefeller University, New York, NY 10021, USA
    Microb Drug Resist 7:349-61. 2001
    ..The data allow tentative identification of an evolutionary pathway for the emergence of pandemic MRSA clones and also provide evidence for the multiple, yet restricted, numbers of acquisition of the mec element by S. aureus...
  38. pmc Methicillin-resistant Staphylococcus aureus in hospitals and the community: stealth dynamics and control catastrophes
    B S Cooper
    Department of Medical Microbiology, Royal Free and University College Medical School, University of London, WC1E 7HU, United Kingdom
    Proc Natl Acad Sci U S A 101:10223-8. 2004
    ..If resources do not scale with MRSA prevalence, isolation policies can fail "catastrophically."..
  39. pmc Community-associated methicillin-resistant Staphylococcus aureus in hospital nursery and maternity units
    Simona Bratu
    State University of New York Downstate, Brooklyn, New York 11203, USA
    Emerg Infect Dis 11:808-13. 2005
    ..CA-MRSA strain MW2 has been present in this region at least since 1999. This study documents the spread of this strain among healthy newborns at 1 hospital...
  40. ncbi DNA microarray-based genotyping of methicillin-resistant Staphylococcus aureus strains from Eastern Saxony
    S Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Clin Microbiol Infect 14:534-45. 2008
    ..Detection of such variants can sometimes allow epidemic strains to be resolved beyond spa types to a hospital-specific level, which is of significant value for epidemiological purposes...
  41. pmc Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications
    H F Chambers
    Medical Service, San Francisco General Hospital 94143, USA
    Clin Microbiol Rev 10:781-91. 1997
    b>Methicillin resistance in staphylococci is determined by mec, composed of 50 kb or more of DNA found only in methicillin-resistant strains...
  42. pmc A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB
    Eoghan O'Neill
    School of Biomolecular and Biomedical Science, University College Dublin, Ardmore House, Belfield, Dublin 4, Ireland
    J Bacteriol 190:3835-50. 2008
    ..These data identify a novel S. aureus biofilm phenotype promoted by FnBPA and FnBPB which is apparently independent of the known ligand-binding activities of these multifunctional surface proteins...
  43. ncbi Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors
    Cassandra D Salgado
    University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin Infect Dis 36:131-9. 2003
    ..24%). Effective control of dissemination of MRSA throughout the community likely will require effective control of nosocomial MRSA transmission...
  44. ncbi Genome and virulence determinants of high virulence community-acquired MRSA
    Tadashi Baba
    Department of Bacteriology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lancet 359:1819-27. 2002
    ..By contrast with hospital-acquired MRSA, community-acquired MRSA is more susceptible to non b-lactam antibiotics. We investigated the high virulence potential of certain strains of this bacterium...
  45. ncbi Methicillin-resistant Staphylococcus aureus disease in three communities
    Scott K Fridkin
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 352:1436-44. 2005
    ..Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. The national burden and clinical effect of this novel presentation of MRSA disease are unclear...
  46. pmc Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus
    Miriam Ender
    Department of Medical Microbiology, University of Zurich, Gloriastr 32, CH8028 Zürich, Switzerland
    Antimicrob Agents Chemother 48:2295-7. 2004
    ..Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate...
  47. pmc Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease
    A Holmes
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, London, NW9 5HT, United Kingdom
    J Clin Microbiol 43:2384-90. 2005
    ..aureus and belonged to 12 different sequence types, including ST22 and ST30, which are closely related to the most prevalent MRSA clones in United Kingdom hospitals, EMRSA-15 and EMRSA-16, respectively...
  48. ncbi A U.S. population-based survey of Staphylococcus aureus colonization
    Philip L Graham
    Department of Pediatrics, Columbia University and New York Presbyterian Medical Center, New York, New York 10032, USA
    Ann Intern Med 144:318-25. 2006
    ..The epidemiology of staphylococcal colonization and community-associated methicillin-resistant Staphylococcus aureus (MRSA) is changing, and little is known from the national perspective...
  49. pmc Origin and molecular evolution of the determinant of methicillin resistance in staphylococci
    Sae Tsubakishita
    Department of Infection Control Science, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 54:4352-9. 2010
    ..MRSA is generated when methicillin-susceptible S. aureus (MSSA) exogenously acquires a methicillin resistance gene, mecA, carried by a mobile genetic element, staphylococcal cassette chromosome mec (SCCmec), which is ..
  50. ncbi Transmission of methicillin-resistant Staphylococcus pseudintermedius between infected dogs and cats and contact pets, humans and the environment in households and veterinary clinics
    E van Duijkeren
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, PO Box 80165, 3508 TD Utrecht, Netherlands
    Vet Microbiol 150:338-43. 2011
    ....
  51. ncbi Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study
    Jorge A Cepeda
    Department of Clinical Microbiology, University College London Hospitals, London W1T 4 JF, UK
    Lancet 365:295-304. 2005
    ..We aimed to assess the effectiveness of moving versus not moving infected or colonised patients in intensive-care units to prevent transmission of MRSA...
  52. pmc The role of virulence determinants in community-associated MRSA pathogenesis
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, 1001 Potrero Avenue, Box 0811, San Francisco, CA 94110, USA
    Trends Microbiol 16:361-9. 2008
    ..Here, we discuss the roles of PVL, the arginine catabolic mobile element and phenol-soluble modulins in the pathogenesis of prevalent CA-MRSA strains...
  53. ncbi Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis
    Evelina Tacconelli
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Antimicrob Chemother 61:26-38. 2008
    ..A systematic review was performed to determine whether antibiotic exposure is a risk factor for the isolation of MRSA...
  54. pmc Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain
    Steven R Gill
    Microbial Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    J Bacteriol 187:2426-38. 2005
    ..Overall differences in pathogenicity can be attributed to genome islands in S. aureus which encode enterotoxins, exotoxins, leukocidins, and leukotoxins not found in S. epidermidis...
  55. ncbi Triplex real-time polymerase chain reaction assay for simultaneous detection of Staphylococcus aureus and coagulase-negative staphylococci and determination of methicillin resistance directly from positive blood culture bottles
    Abdullah Kilic
    Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy and School of Medicine 06018, Ankara, Turkey
    Diagn Microbiol Infect Dis 66:349-55. 2010
    ..7%, respectively, for the tuf, nuc, and mecA gene targets. The triplex real-time PCR assay accurately detects and identifies staphylococci directly from positive blood cultures without nucleic acid extraction prior to amplification...
  56. pmc Controlling methicillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing
    M C J Bootsma
    Department of Mathematics, Utrecht University, Budapestlaan 6, 3508 TA Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 103:5620-5. 2006
    ..RDT can markedly enhance feasibility...
  57. ncbi Carriage frequency, diversity and methicillin resistance of Staphylococcus aureus in Danish small ruminants
    Jacob Eriksson
    Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen Stigbøjlen 4, 1870 Frederiksberg C, Denmark
    Vet Microbiol 163:110-5. 2013
    ..Inclusion of sheep in national MRSA surveillance programmes in animals is advisable in view of this finding...
  58. ncbi Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: fitting a model to the data
    Hajo Grundmann
    Division of Microbiology and Infectious Diseases, University Hospital Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Infect Dis 185:481-8. 2002
    ....
  59. pmc Methicillin-resistant-Staphylococcus aureus hospitalizations, United States
    Matthew J Kuehnert
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:868-72. 2005
    ..aureus-specific diagnoses was multiplied by the proportion of methicillin resistance for each corresponding infection site to determine the number of MRSA infections...
  60. pmc The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
    Mark C Enright
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 99:7687-92. 2002
    ..descent of isolates from each ancestor were inferred by using BURST, which, together with analysis of the methicillin resistance genes, established the likely evolutionary origins of each major MRSA clone, the genotype of the original ..
  61. ncbi Normally functioning murF is essential for the optimal expression of methicillin resistance in Staphylococcus aureus
    R G Sobral
    Molecular Genetics Laboratory, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, 2780 Oeiras, Portugal
    Microb Drug Resist 9:231-41. 2003
    ..Northern analysis demonstrated a drastic reduction in the transcription rate of mecA in mutant F9 whereas mecA transcription increased in the subpopulation of bacteria that retained high-level resistance...
  62. pmc Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus USA300 clone
    Jennifer K Johnson
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Emerg Infect Dis 13:1195-200. 2007
    ..5). The increase in community-associated MRSA infections and the overall increase in SSTIs in our population suggest that USA300 is becoming more virulent and has a greater propensity to cause SSTIs...
  63. ncbi Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus
    Linda M Weigel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 302:1569-71. 2003
    ..Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis...
  64. ncbi Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Division of Infectious Diseases, Boston, MA 02115, USA
    Clin Infect Dis 36:281-5. 2003
    ..Accurate assessment of the risk of MRSA-associated sequelae requires prolonged follow-up after discharge...
  65. ncbi Distribution of the ACME-arcA gene among meticillin-resistant Staphylococcus haemolyticus and identification of a novel ccr allotype in ACME-arcA-positive isolates
    Borui Pi
    State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, PR China
    J Med Microbiol 58:731-6. 2009
    ..The results from this study revealed that MRSH is likely to be one of the potential reservoirs of ACME for Staphylococcus aureus...
  66. pmc Population genetic structure of the Staphylococcus intermedius group: insights into agr diversification and the emergence of methicillin-resistant strains
    Jeanette Bannoehr
    Laboratory for Bacterial Evolution and Pathogenesis, Centre for Infectious Diseases, The Chancellor s Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland
    J Bacteriol 189:8685-92. 2007
    ..pseudintermedius clones found on different continents. Taken together, these data have resolved the population genetic structure of the S. intermedius group, resulting in new insights into its ancient and recent evolution...
  67. ncbi Methicillin-resistant Staphylococcus aureus (MRSA) ST398 associated with clinical and subclinical mastitis in Belgian cows
    Wannes Vanderhaeghen
    Veterinary and Agrochemical Research Center, CODA CERVA VAR, Groeselenberg 99, B 1180 Ukkel, Belgium
    Vet Microbiol 144:166-71. 2010
    ..Yet, as in many other countries, the prevalence of methicillin resistance among S. aureus from mastitis is currently unknown in Belgium...
  68. ncbi Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
    Kyle J Popovich
    Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 46:787-94. 2008
    ..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
  69. ncbi Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus
    Francois Barbier
    Bacteriology Unit and National Reference Center for Emergence of Resistance in Commensal Flora, 2EA 3964, Bichat Claude Bernard Hospital, Assistance Publique Hôpitaux de Paris and Xavier Bichat Medical School, Denis Diderot Paris 7 University, Paris, France
    J Infect Dis 202:270-81. 2010
    ..We assessed their potential role as a reservoir of staphylococcal cassette chromosome mec (SCCmec) IVa, the leading SCCmec subtype in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)...
  70. pmc Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus
    Kunyan Zhang
    Centre for Antimicrobial Resistance, Calgary Health Region Calgary Laboratory Services University of Calgary, Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 43:5026-33. 2005
    ..and specific primers and developed a novel multiplex PCR assay allowing for concomitant detection of the methicillin resistance (mecA gene) (also serving as an internal control) to facilitate detection and classification of all ..
  71. ncbi Factors influencing methicillin resistance in staphylococci
    BRIGITTE BERGER-BACHI
    Institute of Medical Microbiology, University of Zurich, Gloriastrasse 32, PO Box, 8028 Zurich, Switzerland
    Arch Microbiol 178:165-71. 2002
    b>Methicillin resistance in staphylococci is due to an acquired penicillin-binding protein, PBP2' (PBP2a). This additional PBP, encoded by mecA, confers an intrinsic resistance to all beta-lactams and their derivatives...
  72. ncbi Prevalence of methicillin-resistant Staphylococcus aureus among staff and pets in a small animal referral hospital in the UK
    Anette Loeffler
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, London, UK
    J Antimicrob Chemother 56:692-7. 2005
    ....
  73. ncbi Three-year surveillance of community-acquired Staphylococcus aureus infections in children
    Sheldon L Kaplan
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 40:1785-91. 2005
    ..Methicillin-resistant Staphylococcus aureus (MRSA) isolates are increasingly frequent causes of skin and soft-tissue infections or invasive infections in many communities...
  74. pmc Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections
    Clarissa Pozzi
    UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
    PLoS Pathog 8:e1002626. 2012
    ..By introducing the methicillin resistance gene mecA into the PNAG-producing laboratory strain 8325-4 we generated a heterogeneously resistant (HeR) ..
  75. pmc Clonal comparison of Staphylococcus aureus isolates from healthy pig farmers, human controls, and pigs
    Laurence Armand-Lefevre
    Bacteriology Laboratory, Groupe Hospitalier Bichat Claude Bernard, Paris, France
    Emerg Infect Dis 11:711-4. 2005
    ..This finding suggests a high rate of strain exchange between pigs and farmers...
  76. ncbi Suspected transmission of methicillin-resistant Staphylococcus aureus between domestic pets and humans in veterinary clinics and in the household
    J S Weese
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ont Weese, Canada N1G 2W1
    Vet Microbiol 115:148-55. 2006
    ..To describe MRSA infection and colonization in household pets, and transmission of MRSA between animals and humans...
  77. ncbi Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia
    Maria Labandeira-Rey
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Science 315:1130-3. 2007
    ....
  78. pmc Inferring a population structure for Staphylococcus epidermidis from multilocus sequence typing data
    M Miragaia
    Laboratorio de Genetica Molecular, Instituto de Technologia Química e Biológica, Universidade Nova de Lisboa ITQB UNL, Portugal
    J Bacteriol 189:2540-52. 2007
    ..Additionally, we characterized the mobile element (SCCmec) carrying the genetic determinant of methicillin resistance. The 217 S...
  79. ncbi Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
    ..This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution...
  80. ncbi Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus--an emerging problem for the management of skin and soft tissue infections
    E Anne Eady
    School of Biochemistry and Molecular Biology, University of Leeds, UK
    Curr Opin Infect Dis 16:103-24. 2003
    ....
  81. ncbi Widespread rapid emergence of a distinct methicillin- and multidrug-resistant Staphylococcus pseudintermedius (MRSP) genetic lineage in Europe
    Claudia Ruscher
    Institute of Microbiology and Epizootics IMT, Veterinary Faculty, Freie Universitat Berlin, Philippstrasse 13, 10115 Berlin, Germany
    Vet Microbiol 144:340-6. 2010
    ..Our cumulative data indicate a recent emergence of a certain multidrug-resistant MRSP-lineage (ST71) in central and southern European countries during the last few years...
  82. ncbi Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection
    Vance G Fowler
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 196:738-47. 2007
    ..The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear...
  83. ncbi Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
    K Hiramatsu
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    Lancet 350:1670-3. 1997
    ..Two important questions need to be answered: (1) what is the prevalence of VRSA, and (2) by what mechanism does vancomycin resistance occur...
  84. ncbi The emergence and evolution of methicillin-resistant Staphylococcus aureus
    K Hiramatsu
    Department of Bacteriology, Juntendo University, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Trends Microbiol 9:486-93. 2001
    Significant advances have been made in recent years in our understanding of how methicillin resistance is acquired by Staphylococcus aureus...
  85. pmc Cloning and characterization of a gene affecting the methicillin resistance level and the autolysis rate in Staphylococcus aureus
    H Maki
    Kanzakigawa Laboratory, Shionogi and Co, Ltd, Osaka, Japan
    J Bacteriol 176:4993-5000. 1994
    ..aureus strains showed that, whereas nucleotide substitutions occurred at the third position in seven of eight 3'-terminal codons, only C-terminal amino acid variation of glutamate or aspartate was observed...
  86. pmc Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates
    James Collins
    Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
    J Clin Microbiol 46:2112-4. 2008
    ..We found that the beta and delta hemolysins are involved and that methicillin-resistant S. aureus strains are less toxic than methicillin-susceptible S. aureus strains...
  87. ncbi Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin
    Susan Boyle-Vavra
    Department of Pediatrics, Section of Infectious Diseases, University of Chicago, Chicago, IL 60637, USA
    Lab Invest 87:3-9. 2007
    ..In addition to novel methicillin resistance genetic cassettes, many CA-MRSA harbor a phage harboring Panton-Valentine Leukocidin (PVL) genes and some ..
  88. ncbi Surveillance of healthy cats and cats with inflammatory skin disease for colonization of the skin by methicillin-resistant coagulase-positive staphylococci and Staphylococcus schleiferi ssp. schleiferi
    Jill L Abraham
    Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
    Vet Dermatol 18:252-9. 2007
    ..cats with inflammatory skin disease (ISD), to determine prevalence of carriage and relative frequency of methicillin resistance in coagulase-positive staphylococci and Staphylococcus schleiferi ssp. schleiferi...
  89. ncbi A new multiplex PCR for easy screening of methicillin-resistant Staphylococcus aureus SCCmec types I-V
    K Boye
    Department of Clinical Microbiology, Hvidovre Hospital, Hvidovre, Denmark
    Clin Microbiol Infect 13:725-7. 2007
    ..SCCmec type IV was by far the most common SCCmec type among both hospital- and community-acquired MRSA isolates in Denmark...
  90. ncbi Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections at a public hospital: do public housing and incarceration amplify transmission?
    Bala Hota
    Department of Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Intern Med 167:1026-33. 2007
    ..Understanding the epidemiology of CA-MRSA is critical for developing control measures...
  91. pmc Increasing prevalence of methicillin-resistant Staphylococcus aureus causing nosocomial infections at a university hospital in Taiwan from 1986 to 2001
    Po Ren Hsueh
    Department of Laboratory Medicine and Committee of Infection Control, National Taiwan University Hospital, Taipei, Taiwan
    Antimicrob Agents Chemother 48:1361-4. 2004
    ....
  92. pmc Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus
    Sarah K Highlander
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    BMC Microbiol 7:99. 2007
    ..Epidemiological studies suggest that USA300 is more virulent than other CA-MRSA. The genetic determinants that render virulence and dominance to USA300 remain unclear...
  93. pmc Development of homogeneous expression of resistance in methicillin-resistant Staphylococcus aureus clinical strains is functionally associated with a beta-lactam-mediated SOS response
    Arabela Cuirolo
    Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Antimicrob Chemother 64:37-45. 2009
    ..We hypothesized that HeR to HoR selection in these clinically relevant strains may be determined by the pre-existence of a hypermutable population that favours its selection in the presence of oxacillin...
  94. ncbi National prevalence of methicillin-resistant Staphylococcus aureus in inpatients at US health care facilities, 2006
    William R Jarvis
    Jason and Jarvis Associates, Hilton Head Island, SC, USA
    Am J Infect Control 35:631-7. 2007
    ..Despite methicillin-resistant Staphylococcus aureus (MRSA) being endemic in virtually all US health care facilities, there are no data on the prevalence of MRSA in US health care facilities...
  95. ncbi Identification and characterization of methicillin-resistant coagulase-negative staphylococci from bovine mastitis
    Andrea T Fessler
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Neustadt Mariensee, Germany
    J Antimicrob Chemother 65:1576-82. 2010
    ..focused on the correlation between geno- and phenotypic tests in the correct assessment of mecA-mediated methicillin resistance among coagulase-negative staphylococci (CoNS) and the further characterization of mecA-positive isolates.
  96. ncbi Community acquired MRSA infections in a paediatric population in Greece
    S Vourli
    Department of Microbiology, National School of Public Health, Athens, Greece
    Euro Surveill 10:78-9. 2005
    ..They all were found resistant to fusidic acid, tetracycline and kanamycin, and displayed a PFGE pattern identical to that of the well-described ST80 CA-MRSA clone circulating in various European countries...
  97. ncbi Molecular epidemiology of Staphylococcus aureus in asymptomatic carriers
    S Monecke
    Institute for Medical Microbiology and Hygiene, Technical University of Dresden, Fetscherstrasse 74, Dresden 01307, Germany
    Eur J Clin Microbiol Infect Dis 28:1159-65. 2009
    ..These data provide an insight into its pathogenesis, especially when compared to isolates from patients with defined clinical conditions. They might also be helpful for the design of a future vaccine...
  98. pmc Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power
    Herminia De Lencastre
    Laboratory of Microbiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Curr Opin Microbiol 10:428-35. 2007
    ..Then, in the late 1990s, just as effective hygienic and antibiotic use policies managed to bring down the frequency of MRSA in hospitals of several countries, MRSA strains began to show up in the community...
  99. pmc Redefining a structural variant of staphylococcal cassette chromosome mec, SCCmec type VI
    Duarte C Oliveira
    Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica ITQB, Rua da Quinta Grande, Oeiras, Portugal
    Antimicrob Agents Chemother 50:3457-9. 2006
    ..We addressed the epidemiological relevance of this variant and found it among several strains belonging to the same clone. We propose to rename this structural variant SCCmec type VI...
  100. pmc Changing molecular epidemiology of methicillin-resistant Staphylococcus aureus bloodstream isolates from a teaching hospital in Northern Taiwan
    Yhu Chering Huang
    Division of Pediatrics Infectious Diseases, Chang Gung Children s Hospital, Taoyuan, Taiwan
    J Clin Microbiol 44:2268-70. 2006
    ..The changing epidemiology is due to the introduction of a new epidemic clone (sequence type 5) and a local community clone (sequence type 59) of MRSA into the hospital...
  101. ncbi The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94110, USA
    J Infect Dis 197:1523-30. 2008
    ..These data are consistent with a model in which ACME enhances growth and survival of USA300, allowing for genetic "hitchhiking" of SCCmec. SCCmec in turn protects against exposure to beta-lactams...

Research Grants62

  1. Rapid Novel Molecular Detection of Methicillin-Resistant Staphylococcus aureus
    ELENA ANATOLIEVNA USACHEVA; Fiscal Year: 2010
    ..aureus DNA from other species in an analyte with subsequent detection for methicillin resistance;3) evaluate our method by comparison to culture and real-time (q)-PCR assays...
  2. B-lactam mediated SOS response and expression of resistance in clinical MRSA
    Adriana E Rosato; Fiscal Year: 2013
    ..As a consequence, accurate detection of methicillin resistance in S. aureus is not only clinically important but essential for hospital infection control programs...
  3. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2009
    ..The gene responsible for methicillin resistance (MR), mecA, encodes a new PBP (PBP2a) that can maintain cell wall structure but is resistant to [..
  4. Developing a rapid agglutination assay for MRSA.
    NILES PATRICK DONEGAN; Fiscal Year: 2012
    ..aureus has posed major public health problems worldwide. The basis of methicillin resistance in S...
  5. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    GORDON LEE ARCHER; Fiscal Year: 2013
    ..The gene responsible for methicillin resistance (MR), mecA, encodes a new PBP (PBP2a) that can maintain cell wall structure but is resistant to beta-..
  6. Determine the relative virulence and the temporal expression of sarA paralog gen
    Adhar C Manna; Fiscal Year: 2010
    ..The recent emergence of vancomycin and community-associated methicillin resistance S...
  7. Discovery of Small Molecules that Restore Methicillin Sensitivity to MRSA
    JENNIFER CAMPBELL O apos NEILL; Fiscal Year: 2010
    ..Herein, we propose a set of genetic experiments to confirm that methicillin resistance requires the expression of anionic polymer WTAs...
  8. Mechanism and Inhibition of Bacterial Transglycosylases and Transpeptidases.
    Suzanne Walker; Fiscal Year: 2013
    ..The results of the experiments in Aim III have implications for new approaches to overcome MRSA that involve combining a beta-lactam with compounds that target other proteins involved in methicillin resistance.
  9. Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..strains contain mecA, these data indicate that that mecA encoding PBP2A is not the sole determinant of methicillin resistance in CA-MRSA strains...
  10. METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 1993
    ..objective of the proposed research is to identify the components and their interrelationships controlling methicillin resistance in Staphylococcus aureus...
  11. STAPHYLOCOCCAL VANCOMYCIN AND METHICILLIN RESISTANCE
    BRIAN WILKINSON; Fiscal Year: 2001
    ..The investigators propose to study the mechanisms of S. aureus vancomycin and methicillin resistance in laboratory and clinical strains, and their work is organized into three major lines of investigation: I...
  12. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..Recent outbreaks of community-acquired S. aureus possessing methicillin resistance and the emergence of vancomycin-resistant S...
  13. GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASES
    Henry Chambers; Fiscal Year: 1999
    ..aureus autolysins, therapeutics, vancomycin resistance, methicillin resistance, genomics, gene regulation, immunity and vaccine development...
  14. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2003
    ..The trait that defines the multidrug-resistant phenotype is resistance to beta-lactam or methicillin resistance (MR)...
  15. ZOOCIN A AND ITS ASSOCIATED IMMUNITY FACTOR
    GARY SLOAN; Fiscal Year: 2001
    ..Both epr and zif have a high degree of similarity to femAB (factor essential for methicillin resistance) in staphylococci...
  16. Regulation/mecA gene expression/clinic S.aureus isolates
    Adriana Rosato; Fiscal Year: 2005
    ..provide evidence of the existence of additional loci involved in or required for inducible expression of methicillin resistance. These data will provide valuable structure/function information to complement studies investigating the ..
  17. Applied Research on Antimicrobial Ressitance
    Daniel Sexton; Fiscal Year: 2005
    ..Specific aims: i) To define the attributable impact of methicillin resistance upon economic costs of surgical site infections and bloodstream infections due to S. aureus...
  18. Outcomes of and Risk factors for Infections due to USA300 MRSA
    Kristen Kreisel; Fiscal Year: 2007
    ..Antibiotic resistance is common in S. aureus, of which methicillin resistance is the resistance of greatest clinical consequence. Infections due to methicillin-resistant S...
  19. STAPHYLOCOCCUS AND METHICILLIN RESISTANCE ASSAY
    JAMES STORHOFF; Fiscal Year: 2001
    ..These gene targets will determine species identification and methicillin resistance status for seven clinically relevant Staphylococci...
  20. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  21. THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTS
    Loren Miller; Fiscal Year: 2004
    ....
  22. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
    ..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
  23. Device use in Nursing Homes: Reducing Risk of Infection
    Lona Mody; Fiscal Year: 2007
    ..abstract_text> ..
  24. Reducing Antimicrobial Use Associated with Ventilator Associated Pneumonia and Ca
    SARA ELIZABETH COSGROVE; Fiscal Year: 2010
    ..We hypothesize that this approach will enhance appropriate use of antimicrobials for both VAP and CAUTI and improve patient outcomes by reducing the known sequelae of antimicrobial overuse. ..
  25. Nisin-based topical formulation for treatment of anthrax
    John Kokai Kun; Fiscal Year: 2003
    ..The final product is intended to minimize the danger for those exposed to B. anthracis and should also be effective for disinfection of other bioterrorism agents and for nosocomial pathogens in the healthcare setting. ..
  26. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. Prevention of Catheter-Associated Blood Stream Infections
    David Warren; Fiscal Year: 2007
    ..I will build on the experience outlined in this proposal to establish myself an independent investigator in healthcare epidemiology, studying nosocomial infections and developing interventions to prevent them. [unreadable] [unreadable]..
  28. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  29. Hospital-Acquired Infections in the Elderly
    Keith Kaye; Fiscal Year: 2008
    ..The risk factor identified for SSI and MDRB and the impact of SSI and MDRB on health outcomes will be used to design and implement future preventive interventions. ..
  30. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  32. CARDIOTOXICITY OF STREPTOCOCCAL PYROGENIC EXOTOXINS
    Patrick Schlievert; Fiscal Year: 2006
    ....
  33. Quorum sensing, bacterial interaction and disease
    Naomi Balaban; Fiscal Year: 2004
    ..aureus and S. epidermidis, using the murine air sac model. Using the same in vivo model, we will also test the effect of S. xylosus that naturally produces RIP as a probiotic to prevent staphylococcal pathogenesis. ..
  34. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  35. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  36. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..
  37. STAPHYLOCOCCAL COLONIZATION AND DISEASES IN DRUG USERS
    FRANKLIN LOWY; Fiscal Year: 2002
    ..In order to develop these alternatives, we must first understand the strain and host determinants that play a role in this process. ..
  38. In Utero Infection: Child Health and Neurodevelopment
    William Andrews; Fiscal Year: 2005
    ..abstract_text> ..
  39. Mathematical Modeling of the Superspreaders of Antibiotic-Resistante Bacteria
    Shigui Ruan; Fiscal Year: 2010
    ..The proposed work will lead to a better understanding of the factors which contribute to the spread of ARB, and will allow the development and implementation of effective public health policies. ..
  40. PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 2003
    ..The objective of this research is to further knowledge of mechanisms of methicillin resistance. Resistance is determined by several proteins that interact with penicillin...
  41. HOME HYGIENE INTERVENTION
    Elaine Larson; Fiscal Year: 2002
    ..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
  42. RATIONAL DESIGN OF ANTISICKLING AGENTS
    MARTIN SAFO; Fiscal Year: 2002
    ....
  43. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  44. S AUREUS PATHOGENESIS IN HIV INFECTION AND IN DRUG USE
    FRANKLIN LOWY; Fiscal Year: 2002
    ..The ability to integrate both epidemiologic and biologic studies using a well defined high risk cohort of drug users and HIV-infected subjects provides an ideal setting to examine these issues. ..
  45. N-Thiolated Beta-Lactams
    Edward Turos; Fiscal Year: 2006
    ..We believe that these studies will provide extraordinary opportunities to develop new therapeutics and approaches for the control of hospital-borne drug-resistant infections. ..
  46. MRSA Colonization and Control in the Cook County Jail - R01
    Robert Daum; Fiscal Year: 2008
    ..We hope that the Cook County jail will become a model jail for the control of MRSA and other resistant bacteria. [unreadable] [unreadable] [unreadable]..
  47. Novel antibacterial agents for treatment of Tularemia
    Nachum Kaplan; Fiscal Year: 2004
    ..tularensis microbiological data and animal model data to warrant inclusion of the information on the product label as a narrow spectrum agent that could be used in the event of a F. tularensis release. ..
  48. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  49. MECHANISMS OF GLYCOPEPTIDE RESISTANCE IN STAPHYLOCOCCI
    Robert Daum; Fiscal Year: 2006
    ..These studies should lead to an understanding of the mechanisms by which S. aureus resist the bactericidal effect of GPs and hopefully can identify new ideas regarding therapy of infections caused by resistant isolates. ..
  50. Social Networks of S. aureus Carriage Among Drug Users
    FRANKLIN LOWY; Fiscal Year: 2006
    ..Miller's preexistent cohort of women drug users and their network members in the Bedford Stuyvesant section of Brooklyn. This will allow for the rapid integration of this investigation into her ongoing study. ..
  51. Food Safety Task Force Conference
    Timothy Jones; Fiscal Year: 2005
    ..Abstract Not Provided ..
  52. Rational Design of Novel Estrogen Receptor Antagonists
    MARTIN SAFO; Fiscal Year: 2007
    ..A long-range goal of this proposal is to generate and optimize antiestrogens that are "pure" alpha-receptor antagonists. ..
  53. Obesity in Hispanic Children with Leukemia
    Jacques Baillargeon; Fiscal Year: 2005
    ..abstract_text> ..
  54. Mathematical Modeling of Epidemic and Endemic Cholera
    David Hartley; Fiscal Year: 2007
    ..Such an understanding may also afford us insight into new prevention, intervention and control strategies to limit or prevent the occurrence of this potentially devastating disease. ..
  55. Racial Disparities in Diabetes in the US and the UK
    Arch Mainous; Fiscal Year: 2005
    ..abstract_text> ..
  56. Structure of Beta-lactam resistance regulators
    MARTIN SAFO; Fiscal Year: 2007
    ..Subsequently, the structures of the proteins will be determined using X-ray crystallography. [unreadable] [unreadable]..
  57. Quorum sensing and Staphylococcus aureus pathogenesis
    Naomi Balaban; Fiscal Year: 2005
    ..Such immune intervention would greatly benefit people suffering from acute drug resistant infections or surgery-related infections often associated with implantable medical devices. ..
  58. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  59. ANTIBIOTIC INHIBITION OF BACTERIAL RIBOSOME FORMATION
    WILLIAM CHAMPNEY; Fiscal Year: 2002
    ..The findings from this work will help in assessing the effectiveness of existing antibiotics and in developing new compounds as antimicrobial agents. ..
  60. Staff Hand Hygiene and Nosocomial Infections in Neonates
    Elaine Larson; Fiscal Year: 2003
    ....
  61. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  62. Interdisciplinary Research:Antimicrobial Resistance(RMI)
    Elaine Larson; Fiscal Year: 2006
    ..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..