penicillin resistance

Summary

Summary: Nonsusceptibility of an organism to the action of penicillins.

Top Publications

  1. pmc A European study on the relationship between antimicrobial use and antimicrobial resistance
    Stef L A M Bronzwaer
    National Institute of Public Health and the Environment, Department of Infectious Disease Epidemiology, Postbak 75, PO Box 1, Antonie van Leeuwenhoeklaan 9, 3720 BA Bilthoven, The Netherlands
    Emerg Infect Dis 8:278-82. 2002
  2. ncbi Increased penicillin nonsusceptibility of nonvaccine-serotype invasive pneumococci other than serotypes 19A and 6A in post-7-valent conjugate vaccine era
    Robert E Gertz
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 201:770-5. 2010
  3. ncbi Streptococcus pneumoniae R6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome-wide recombination events
    Julia Sauerbier
    Department of Microbiology, University of Kaiserslautern, Kaiserslautern, Germany
    Mol Microbiol 86:692-706. 2012
  4. pmc Serotype competence and penicillin resistance in Streptococcus pneumoniae
    Yu Chia Hsieh
    Taipei Municipal WanFang Hospital, Taipei, Taiwan
    Emerg Infect Dis 12:1709-14. 2006
  5. ncbi Penicillin resistance and serotype distribution of Streptococcus pneumoniae in nasopharyngeal carrier children under 5 years of age in Dar es Salaam, Tanzania
    Sabrina J Moyo
    Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    J Med Microbiol 61:952-9. 2012
  6. ncbi A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter
    Hafid Soualhine
    Centre de Recherche en Infectiologie et Division de Microbiologie, Faculte de Medecine, Universite Laval, Quebec City, Canada
    Mol Microbiol 58:1430-40. 2005
  7. pmc Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance
    Svetolik Djurkovic
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Antimicrob Agents Chemother 49:1225-8. 2005
  8. pmc Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae
    Shuqing Zhao
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    Antimicrob Agents Chemother 53:3744-51. 2009
  9. pmc Lipid II-independent trans editing of mischarged tRNAs by the penicillin resistance factor MurM
    Jennifer Shepherd
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 288:25915-23. 2013
  10. ncbi Molecular characteristics of penicillin-binding protein genes of penicillin-nonsusceptible Streptococcus pneumoniae isolated in the Netherlands
    K Overweg
    Department of Pediatrics, Sophia Children's Hospital/Erasmus University Rotterdam, The Netherlands
    Microb Drug Resist 7:323-34. 2001

Research Grants

Detail Information

Publications219 found, 100 shown here

  1. pmc A European study on the relationship between antimicrobial use and antimicrobial resistance
    Stef L A M Bronzwaer
    National Institute of Public Health and the Environment, Department of Infectious Disease Epidemiology, Postbak 75, PO Box 1, Antonie van Leeuwenhoeklaan 9, 3720 BA Bilthoven, The Netherlands
    Emerg Infect Dis 8:278-82. 2002
    ..Our results show that in Europe antimicrobial resistance of S. pneumoniae to penicillin is correlated with use of beta-lactam antibiotics and macrolides...
  2. ncbi Increased penicillin nonsusceptibility of nonvaccine-serotype invasive pneumococci other than serotypes 19A and 6A in post-7-valent conjugate vaccine era
    Robert E Gertz
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 201:770-5. 2010
    ....
  3. ncbi Streptococcus pneumoniae R6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome-wide recombination events
    Julia Sauerbier
    Department of Microbiology, University of Kaiserslautern, Kaiserslautern, Germany
    Mol Microbiol 86:692-706. 2012
    Interspecies gene transfer has been implicated as the major driving force for the evolution of penicillin resistance in Streptococcus pneumoniae. Genomic alterations of S...
  4. pmc Serotype competence and penicillin resistance in Streptococcus pneumoniae
    Yu Chia Hsieh
    Taipei Municipal WanFang Hospital, Taipei, Taiwan
    Emerg Infect Dis 12:1709-14. 2006
    ..Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important...
  5. ncbi Penicillin resistance and serotype distribution of Streptococcus pneumoniae in nasopharyngeal carrier children under 5 years of age in Dar es Salaam, Tanzania
    Sabrina J Moyo
    Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    J Med Microbiol 61:952-9. 2012
    ..These findings indicate that the carriage rate of such resistant strains could be influenced by an appropriate vaccination programme in the study setting and by reinforcing regulations on the rational use of antimicrobial agents...
  6. ncbi A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter
    Hafid Soualhine
    Centre de Recherche en Infectiologie et Division de Microbiologie, Faculte de Medecine, Universite Laval, Quebec City, Canada
    Mol Microbiol 58:1430-40. 2005
    ..To further link the expression of the ABC phosphate transporter with penicillin resistance, we looked at pstS mRNA levels in 12 independent clinical isolates sensitive and resistant to penicillin ..
  7. pmc Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance
    Svetolik Djurkovic
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Antimicrob Agents Chemother 49:1225-8. 2005
    ..Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain...
  8. pmc Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae
    Shuqing Zhao
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    Antimicrob Agents Chemother 53:3744-51. 2009
    ..e., mtrR, penB, and/or ponA1) that are required for high-level penicillin resistance. To define the individual contributions of these determinants to reduced susceptibility to ceftriaxone and ..
  9. pmc Lipid II-independent trans editing of mischarged tRNAs by the penicillin resistance factor MurM
    Jennifer Shepherd
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 288:25915-23. 2013
    ..b>Penicillin resistance in S...
  10. ncbi Molecular characteristics of penicillin-binding protein genes of penicillin-nonsusceptible Streptococcus pneumoniae isolated in the Netherlands
    K Overweg
    Department of Pediatrics, Sophia Children's Hospital/Erasmus University Rotterdam, The Netherlands
    Microb Drug Resist 7:323-34. 2001
    ..Finally, novel mosaic structures were identified indicating horizontal exchange of pbp gene parts among penicillin-nonsusceptible pneumococci...
  11. ncbi A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori
    Takeshi Okamoto
    Department of Microbiology, Yamaguchi University School of Medicine, Minamikogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    J Antimicrob Chemother 50:849-56. 2002
    ..pylori isolated in Korea...
  12. ncbi Imipenem resistance in clinical isolates of Proteus mirabilis associated with alterations in penicillin-binding proteins
    C Neuwirth
    Laboratoire de Bacteriologie, Hopital Universitaire du Bocage, Dijon, France
    J Antimicrob Chemother 36:335-42. 1995
    ..These findings suggest that imipenem resistance in P. mirabilis might result from altered PBPs, as reported for Acinetobacter baumanii and Pseudomonas aeruginosa...
  13. pmc Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999--2000, including a comparison of resistance rates since 1994--1995
    G V Doern
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Antimicrob Agents Chemother 45:1721-9. 2001
    ..1%; tetracycline, 9.0%; TMP-SMX, 9.1%; and chloramphenicol, 4.0%, the increase in multiresistance was 13.3%. Despite awareness and prevention efforts, antimicrobial resistance with S. pneumoniae continues to increase in the United States...
  14. ncbi Antimicrobial susceptibility of Staphylococcus aureus and characterization of methicillin-resistant Staphylococcus aureus isolated from bovine mastitis in Korea
    Hyang Mi Nam
    Bacteriology and Parasitology Division, National Veterinary Research and Quarantine Service, Anyang, Republic of Korea
    Foodborne Pathog Dis 8:231-8. 2011
    ..The results of this study provide evidence of CA-MRSA infection in dairy cattle for the first time in Korea...
  15. ncbi Laboratory-based surveillance of Streptococcus pneumoniae invasive disease in children in 10 Latin American countries: a SIREVA II project, 2000-2005
    Elizabeth Castaneda
    Grupo de Microbiologia, Instituto Nacional de Salud, Bogota, Colombia
    Pediatr Infect Dis J 28:e265-70. 2009
    ....
  16. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
    ..Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan...
  17. pmc Etiology and antimicrobial susceptibility of udder pathogens from cases of subclinical mastitis in dairy cows in Sweden
    Ylva Persson
    Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, SE 75189 Uppsala, Sweden
    Acta Vet Scand 53:36. 2011
    ..The aim was to investigate the microbial panorama and the occurrence of antimicrobial resistance. Moreover, differences between newly infected cows and chronically infected cows were investigated...
  18. pmc Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes
    S R Filipe
    Laboratory of Microbiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:4891-6. 2000
    ..However the relationship between cell wall abnormality and penicillin resistance has remained obscure. We now show that the genome of S...
  19. ncbi Distribution and antimicrobial resistance of clinical and subclinical mastitis pathogens in dairy cows in Rhône-Alpes, France
    Marie Anne Botrel
    Agence Francaise de Securite Sanitaire des Aliments, Lyon, France
    Foodborne Pathog Dis 7:479-87. 2010
    ..However, it also confirms the fact that attention must be maintained to avoid any emergence of such resistant bacteria...
  20. pmc Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis
    B G Spratt
    Microbial Genetics Group, School of Biological Sciences, University of Sussex, Brighton, United Kingdom
    Proc Natl Acad Sci U S A 86:8988-92. 1989
    ..flavescens, or a very similar commensal Neisseria species, appears to have occurred independently during the development of altered penA genes in non-beta-lactamase-producing penicillin-resistant strains of N. gonorrhoeae...
  21. ncbi Oropharyngeal carriage and penicillin resistance of Neisseria meningitidis in primary school children in Manisa, Turkey
    H Gazi
    Celal Bayar University Medicine Faculty, Department of Microbiology and Clinical Microbiology, Turkey
    Ann Acad Med Singapore 33:758-62. 2004
    To determine the oropharyngeal carriage rates and serogroups of Neisseria meningitidis in primary school children in Manisa, Turkey as well as the prevalence and penicillin resistance of N. meningitidis.
  22. pmc High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
    Jae Hoon Song
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Asian Pacific Research Foundation for Infectious Diseases, 50 IL Won Dong, Kangnam Ku, Seoul 135 710, Korea
    Antimicrob Agents Chemother 48:2101-7. 2004
    ..Isolates from Vietnam showed the highest prevalence of penicillin resistance (71.4%), followed by those from Korea (54.8%), Hong Kong (43.2%), and Taiwan (38.6%)...
  23. pmc Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae
    D J Diekema
    University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Emerg Infect Dis 6:552-6. 2000
    ..S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of beta-lactam antimicrobial drugs...
  24. ncbi Determination of penicillin resistance in Streptococcus pneumoniae isolates from southern Brazil by PCR
    Eduardo Walker Zettler
    Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Avenida Ipiranga, 6690 conjunto 501, Bairro Jardim Botânico, Porto Alegre RS, CEP 90660 000, Brazil
    Int J Infect Dis 10:110-5. 2006
    ..To demonstrate the potential clinical applicability of the PCR technique to the early detection of bacterial resistance in Streptococcus pneumoniae...
  25. ncbi Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae
    M Inês Crisóstomo
    Laboratory of Microbiology, The Rockefeller University, New York, NY, USA
    Mol Microbiol 61:1497-509. 2006
    The level of penicillin resistance in clinical isolates of Streptococcus pneumoniae depends not only on the reduced affinity of penicillin binding proteins (PBPs) but also on the functioning of enzymes that modify the stem peptide ..
  26. pmc Short- and long-term effects of pneumococcal conjugate vaccination of children on penicillin resistance
    L Temime
    INSERM U444 27, Epidémiologie et Sciences de l Information, rue Chaligny, 75571 Paris Cedex 12, France
    Antimicrob Agents Chemother 48:2206-13. 2004
    ..As a consequence, vaccination alone may not be successful in controlling selection for resistance in S. pneumoniae...
  27. ncbi Emergence of a novel penicillin-nonsusceptible, invasive serotype 35B clone of Streptococcus pneumoniae within the United States
    Bernard Beall
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 186:118-22. 2002
    ..The mosaic pbp2b and divergent ddl sequences were suggestive of interspecies recombination at the ddl-pbp2b chromosomal region...
  28. ncbi Diversity of penicillin-nonsusceptible Streptococcus pneumoniae circulating in Iceland after the introduction of penicillin-resistant clone Spain(6B)-2
    Raquel Sá-Leão
    Laboratory of Microbiology, Rockefeller University, New York, New York 10021, USA
    J Infect Dis 186:966-75. 2002
    ..The major mechanism of dissemination of penicillin resistance in Iceland appears to be the repeated introduction of multiple lineages, followed by clonal spread.
  29. pmc Single-step capsular transformation and acquisition of penicillin resistance in Streptococcus pneumoniae
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Bacteriol 186:3447-52. 2004
    ..This suggests that in natural settings selection by host immunity and selection by antibiotics may be interrelated because of "hitchhiking" effects due to linkage of resistance determinants and the capsule locus...
  30. ncbi Correlation between substitutions in penicillin-binding protein 1 and amoxicillin resistance in Helicobacter pylori
    Emiko Rimbara
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji shi, Tokyo 192 0392, Japan
    Microbiol Immunol 51:939-44. 2007
    ..pylori isolates had multiple substitutions including Asn562-->Tyr. These results suggest that multiple amino acid substitutions in the transpeptidase region of PBP1 are closely related to amoxicillin resistance in H. pylori...
  31. ncbi Cell wall branches, penicillin resistance and the secrets of the MurM protein
    Andras Fiser
    Department of Biochemistry and Seaver Foundation Center for Bioinformatics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Trends Microbiol 11:547-53. 2003
    ..Cells in which murM was inactivated produced cell walls without branches and also completely lost penicillin resistance. To understand these surprising observations a 3D-model of MurM was constructed, which helped to put into ..
  32. ncbi The spread of multiply resistant Streptococcus pneumoniae at a day care center in Ohio
    M R Reichler
    Respiratory Diseases Branch, Centers for Disease Control, Atlanta, Georgia 30333
    J Infect Dis 166:1346-53. 1992
    ..001). Strategies to limit the spread of highly resistant pneumococcal strains should include encouraging judicious use of antimicrobic agents and reevaluating indications for prophylactic use of antimicrobic agents...
  33. pmc The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3FY, United Kingdom
    J Clin Microbiol 37:3210-6. 1999
    ....
  34. pmc Alterations in PBP 1A essential-for high-level penicillin resistance in Streptococcus pneumoniae
    A M Smith
    MRC SAIMR Wits Pneumococcal Diseases Research Unit, Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, Johannesburg, South Africa
    Antimicrob Agents Chemother 42:1329-33. 1998
    High-level penicillin resistance in pneumococci is due to alterations in penicillin-binding proteins (PBPs) 2X, 2B, and 1A...
  35. ncbi Clonal spread of resistant pneumococci despite diminished antimicrobial use
    Vilhjalmur A Arason
    Department of Family Medicine, University of Iceland, Solvangur, Hafnarfjordur
    Microb Drug Resist 8:187-92. 2002
    ..Clonal spread and herd immunity are important factors to be considered in the evaluation of intervention effects...
  36. ncbi Amoxycillin resistance is one reason for failure of amoxycillin-omeprazole treatment of Helicobacter pylori infection
    M P Dore
    Institute of Internal Medicine, University of Medicine, Sassari, Italy
    Aliment Pharmacol Ther 12:635-9. 1998
    ..The aim of this study was to assess the role of pre-treatment amoxycillin resistance in the efficacy of omeprazole and amoxycillin dual therapy...
  37. ncbi Pneumococcal nasopharyngeal carriage and patterns of penicillin resistance in young children in Fiji
    F M Russell
    Centre for International Child Health, Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Ann Trop Paediatr 26:187-97. 2006
    ..We set out to document pneumococcal nasopharyngeal carriage and associated risk factors, antimicrobial resistance and serotypes in healthy children in Fiji...
  38. pmc Identification of three major clones of multiply antibiotic-resistant Streptococcus pneumoniae in Taiwanese hospitals by multilocus sequence typing
    Z Y Shi
    School of Biological Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom
    J Clin Microbiol 36:3514-9. 1998
    ..Single isolates of the Spanish penicillin-resistant serotype 9V clone and the Spanish multidrug-resistant serotype 6B clone were also identified in the collection...
  39. pmc Spread of Staphylococcus aureus resistant to penicillin and tetracycline within and between dairy herds
    S Waage
    Section of Cattle Health, National Veterinary Institute, Oslo, Norway
    Epidemiol Infect 129:193-202. 2002
    ..aureus occurring in dairy herds in Norway mainly seems to represent one particular strain that has achieved widespread distribution or belong to one of several different strains carrying identical plasmids...
  40. ncbi Methods for identifying methicillin resistancein Staphylococcus aureus
    R W Smyth
    Department of Microbiology, Central Hospital, Vaxjo, SE 351 85, Sweden
    J Hosp Infect 48:103-7. 2001
    ..Ltd., Japan) and Evigene MRSA Detection Kit (State Serum Institute, Denmark) tests were in complete agreement with results obtained with polymerase chain reaction assays amplifying mecA and nuc gene sequences...
  41. ncbi Herd-level association between antimicrobial use and antimicrobial resistance in bovine mastitis Staphylococcus aureus isolates on Canadian dairy farms
    V Saini
    Department of Production Animal Health, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    J Dairy Sci 95:1921-9. 2012
    ..17 and 3.10, respectively]. Systemic administration of penicillin was associated with penicillin resistance (OR: 1.63)...
  42. pmc Towards an understanding of chromosomally mediated penicillin resistance in Neisseria gonorrhoeae: evidence for a porin-efflux pump collaboration
    William M Shafer
    Laboratory of Bacterial Pathogenesis, Room 5A181, VA Medical Center, Decatur, GA 30033, USA
    J Bacteriol 188:2297-9. 2006
  43. ncbi Complex relationship between acquisition of beta-lactam resistance and loss of virulence in Streptococcus pneumoniae
    V Rieux
    Institut National de la Sante et de la Recherche Medicale, Hopital Bichat Claude Bernard, Paris, France
    J Infect Dis 184:66-72. 2001
    ..Sequence analysis results of the pbp2b and pbpX alleles from these strains were in keeping with acquired penicillin resistance. The virulence of these strains was significantly reduced, which shows a relationship between beta-lactam ..
  44. ncbi Temporal trends of invasive disease due to Streptococcus pneumoniae among children in the intermountain west: emergence of nonvaccine serogroups
    Carrie L Byington
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA
    Clin Infect Dis 41:21-9. 2005
    ..Use of the heptavalent pneumococcal conjugate vaccine (PCV-7 [Prevnar]) has been associated with decreased a incidence of invasive pneumococcal disease (IPD) among children in the United States...
  45. ncbi Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment
    B H P van den Borne
    Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    J Dairy Sci 93:2550-8. 2010
    ..The correlation between penicillin resistance, cell counts, and host adaptation may affect the association between host adaptation and cure...
  46. pmc Efficacy of targeted 5-day combined parenteral and intramammary treatment of clinical mastitis caused by penicillin-susceptible or penicillin-resistant Staphylococcus aureus
    S Taponen
    Faculty of Veterinary Medicine, Department of Clinical Veterinary Sciences, University of Helsinki, Finland
    Acta Vet Scand 44:53-62. 2003
    ..3%. The difference in cure rates between mastitis due to penicillin-susceptible and penicillin-resistant S. aureus was highly significant. Combined treatment was superior over systemic treatment only in the beta-lactamase negative group...
  47. ncbi The molecular epidemiology of penicillin-resistant Streptococcus pneumoniae in the United States, 1994-2000
    S S Richter
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 34:330-9. 2002
    ....
  48. pmc Identification and analysis of amino acid mutations in porin IB that mediate intermediate-level resistance to penicillin and tetracycline in Neisseria gonorrhoeae
    Melanie Olesky
    Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7365, USA
    Antimicrob Agents Chemother 46:2811-20. 2002
    ..These studies demonstrate that charged amino acids at positions 120 and 121 in PIB are highly preferential for conferring resistance to penicillin and tetracycline in N. gonorrhoeae...
  49. ncbi Antibiotic resistance in Streptococcus pneumoniae in six Latin American countries: 1993-1999 surveillance
    M Hortal
    Departamento Materno infantil y Laboratorio de Salud Pública, Ministerio de Salud, Montevideo, Uruguay
    Microb Drug Resist 7:391-401. 2001
    ..High levels of antibiotic resistance in Latin America emphasize the need for the development of and adherence to rational antibiotic use guidelines. On-going surveillance will monitor the impact of these programs...
  50. ncbi Evolution of Streptococcus pneumoniae serotypes and penicillin susceptibility in Latin America, Sireva-Vigía Group, 1993 to 1999. PAHO Sireva-Vigía Study Group. Pan American Health Organization
    J L Di Fabio
    Division of Vaccines and Immunization, Pan American Health Organization, Washington, DC, USA
    Pediatr Infect Dis J 20:959-67. 2001
    ....
  51. ncbi Serotype-specific penicillin resistance of Streptococcus pneumoniae in Germany from 1992 to 2008
    Matthias Imohl
    Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH, Pauwelsstr 30, 52074 Aachen, Germany
    Int J Med Microbiol 300:324-30. 2010
    ..While the nonsusceptibility among serotype 19A isolates increased considerably over the years, the development of nonsusceptibility rates among the other serotypes is less and more ambiguous...
  52. ncbi A community intervention trial to promote judicious antibiotic use and reduce penicillin-resistant Streptococcus pneumoniae carriage in children
    E A Belongia
    Marshfield Medical Research Foundation and Marshfield Clinic, Marshfield, Wisconsin, USA
    Pediatrics 108:575-83. 2001
    ..The objective of this study was to assess the impact of parent and clinician education on pediatric antibiotic prescribing and carriage of penicillin-nonsusceptible Streptococcus pneumoniae in child care facilities...
  53. pmc Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
    Wendy L Veal
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Bacteriol 184:5619-24. 2002
    The importance of the mtrCDE-encoded efflux pump in conferring chromosomally mediated penicillin resistance on certain strains of Neisseria gonorrhoeae was determined by using genetic derivatives of penicillin-sensitive strain FA19 ..
  54. ncbi Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States
    Althea W McCormick
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 9:424-30. 2003
    ....
  55. ncbi Pneumococcal meningitis in children: relationship of antibiotic resistance to clinical characteristics and outcomes
    S C Buckingham
    Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children s Medical Center, Memphis, TN, USA
    Pediatr Infect Dis J 20:837-43. 2001
    ..Previous studies have been limited by inclusion of relatively few patients infected with nonsusceptible pneumococci and inconsistent use of empiric vancomycin...
  56. pmc An extracytoplasmic function sigma factor controls beta-lactamase gene expression in Bacillus anthracis and other Bacillus cereus group species
    Cana L Ross
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Bacteriol 191:6683-93. 2009
    ..B. cereus and B. thuringiensis sigP and rsiP homologues are required for inducible penicillin resistance in these species. Expression of the B. cereus or B. thuringiensis sigP and rsiP genes in a B...
  57. ncbi Emergence of penicillin-nonsusceptible Streptococcus pneumoniae clones expressing serotypes not present in the antipneumococcal conjugate vaccine
    Nurith Porat
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
    J Infect Dis 190:2154-61. 2004
    ..Penicillin-nonsusceptible Streptococcus pneumoniae isolates are confined mainly to a few serogroups. Capsular transformation may serve as a mechanism for spreading antibiotic resistance to new serotypes...
  58. pmc Implications of Streptococcus pneumoniae penicillin resistance and serotype distribution in Kuwait for disease treatment and prevention
    Eiman M Mokaddas
    Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait
    Clin Vaccine Immunol 15:203-7. 2008
    Streptococcus pneumoniae causes serious infections. Treatment is difficult because of the emergence of penicillin resistance in S. pneumoniae. Pneumococcal vaccines offer the promise of control and prevention of pneumococcal infections...
  59. pmc Invasive pneumococcal infections in Denmark from 1995 to 1999: epidemiology, serotypes, and resistance
    Helle Bossen Konradsen
    Streptococcus Unit, Department of Respiratory Infections, Meningitis and STIs, Division of Microbiology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Clin Diagn Lab Immunol 9:358-65. 2002
    ..0%). These observations underline the importance of adequate surveillance systems of invasive pneumococcal disease to introduce and maintain national vaccine strategies and adequate antibiotic policy...
  60. ncbi Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials
    Glenn A Pankuch
    Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
    J Antimicrob Chemother 51:443-6. 2003
    ..0 mg/L. Time-kill assays with eight strains demonstrated that daptomycin (2 x MIC) was bactericidal in seven of eight strains tested at 24 h, with >90% killing at 1 h...
  61. ncbi Penicillin susceptibility and molecular characteristics of clinical isolates of Streptococcus pneumoniae at the University of Malaya Medical Center, Kuala Lumpur, Malaysia
    Mohd Nasir Mohd Desa
    Department of Clinical Laboratory Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Malaysia
    Int J Infect Dis 7:190-7. 2003
    To determine the prevalence of penicillin resistance and molecular characteristics of pneumococcal isolates at the University of Malaya Medical Center.
  62. ncbi An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome
    Victor L Yu
    Division of Infectious Disease, University of Pittsburgh, PA, USA
    Clin Infect Dis 37:230-7. 2003
    ..of illness, and underlying disease with immunosuppression were significantly associated with mortality; penicillin resistance was not a risk factor for mortality. The impact of concordant antibiotic therapy (i.e...
  63. ncbi Antibiotic susceptibility and serotypes of Streptococcus pneumoniae isolates from Hungary
    Orsolya Dobay
    Medical Microbiology, Medical School, Teviot Place, University of Edinburgh, Edinburgh EH8 9AG, UK
    J Antimicrob Chemother 51:887-93. 2003
    Hungary has reported one of the highest incidences of penicillin resistance in Streptococcus pneumoniae in Europe since the 1970s and is still cited accordingly...
  64. ncbi In-vitro activity of levofloxacin against Streptococcus pneumoniae with various levels of penicillin resistance
    K S Thomson
    Creighton University School of Medicine, Omaha, Nebraska, USA
    J Antimicrob Chemother 43:15-9. 1999
    ..These data suggest that the efficacy of levofloxacin should be examined in both adult and paediatric S. pneumoniae infections involving body sites where levofloxacin concentrations > 2 mg/L can be achieved safely...
  65. ncbi Increase in penicillin resistance of invasive Streptococcus pneumoniae in Brazil after 1999
    Maria Cristina C Brandileone
    J Antimicrob Chemother 56:437-9. 2005
  66. ncbi Penicillin resistance and serotypes/serogroups of Streptococcus pneumoniae in nasopharyngeal carrier children younger than 2 years in Lima, Peru
    Theresa J Ochoa
    Division of Pediatric Infectious Diseases, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Diagn Microbiol Infect Dis 52:59-64. 2005
    ..Only 65% of the isolated strains had serogroups found in the 7-valent conjugate pneumococcal vaccine. This highlights the importance of regional surveillance studies for effective vaccine strategies and treatment protocols...
  67. ncbi Drug-resistant pneumococcal pneumonia: clinical relevance and related factors
    Javier Aspa
    Servicio de Neumologia, Hospital de la Princesa, Madrid, Spain
    Clin Infect Dis 38:787-98. 2004
    ..In summary, the rate of resistance to beta -lactams and macrolides among S. pneumoniae that cause CAP remains high, but such resistance does not result in increased morbidity...
  68. ncbi Diversity and evolution of blaZ from Staphylococcus aureus and coagulase-negative staphylococci
    John Elmerdahl Olsen
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, 4 Stigbøjlen, DK 1870 Frederiksberg C, Denmark
    J Antimicrob Chemother 57:450-60. 2006
    ....
  69. ncbi Mechanisms other than penicillin-binding protein-2 alterations may contribute to moderate penicillin resistance in Neisseria meningitidis
    P Orús
    Laboratori de Microbiologia, Biomedical Research Center of Bellvitge, Campus de Bellvitge, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Barcelona, Spain
    Int J Antimicrob Agents 18:113-9. 2001
    b>Penicillin resistance in Neisseria spp is thought to be generated by the interspecies transfer of genetic material from naturally penicillin-resistant, commensal species...
  70. ncbi Antimicrobial susceptibilities of amoxycillin-non-susceptible and susceptible isolates among penicillin-non-susceptible Streptococcus pneumoniae
    E Perez-Trallero
    Department of Microbiology, Hospital Donostia, San Sebastian, Spain
    Clin Microbiol Infect 13:937-40. 2007
    ..Spain(14)-5 was the most problematic clone in terms of antibiotic resistance...
  71. pmc Population-based survey of antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from meningitis patients in Salvador, Brazil
    Joice Neves Reis
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Brazil
    J Clin Microbiol 40:275-7. 2002
    ..vaccine was 74% among patients <5 years of age and 94% among those infected with nonsusceptible isolates, indicating that the use of conjugate vaccines may be an approach to the control of emerging penicillin resistance in Brazil.
  72. pmc Importance of local variations in antibiotic consumption and geographical differences of erythromycin and penicillin resistance in Streptococcus pneumoniae
    Cesar Garcia-Rey
    Medical Department, GlaxoSmithKline, Madrid, Spain
    J Clin Microbiol 40:159-64. 2002
    ..are quantitatively and qualitatively responsible for the different local rates of erythromycin and penicillin resistance in Streptococcus pneumoniae in Spain is presented...
  73. ncbi Breakthrough in penicillin resistance? Streptococcus pneumoniae isolates with penicillin/cefotaxime MICs of 16 mg/L and their genotypic and geographical relatedness
    Francisco Soriano
    Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz, Madrid, Spain
    J Antimicrob Chemother 62:1234-40. 2008
    ..Nine isolates were from Romania (9/162; 5.56%) and two from Poland (2/305; 0.66%)...
  74. ncbi Penicillin resistance not a factor in outcome from invasive Streptococcus pneumoniae community-acquired pneumonia in adults when appropriate empiric therapy is started
    Maurice A Mufson
    Department of Medicine, Marshall University, Joan C Edwards School of Medicine, Huntington, West Virginia 25701 3655, USA
    Am J Med Sci 333:161-7. 2007
    ....
  75. ncbi Two major Spanish clones of penicillin-resistant Streptococcus pneumoniae in Portuguese isolates of clinical origin
    Manuela Caniça
    Antibiotic Resistance Unit, Centre of Bacteriology, National Institute of Health Dr Ricardo Jorge, Av Padre Cruz, 1649 016 Lisbon, Portugal
    J Antimicrob Chemother 51:409-14. 2003
    ..In this study, serotypes 9V and 23F have different clonal origins and identical PBP genotypes, suggesting a horizontal transfer of resistance. Visual and computer-assisted analysis of PFGE patterns correlated well (r = 0.983)...
  76. ncbi Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae
    D Sevillano
    Microbiology Department, School of Medicine, Univ Complutense, Avda Complutense s n, 28040 Madrid, Spain
    J Antimicrob Chemother 60:156-8. 2007
    ..To elucidate this issue we examined bacterial killing kinetics at cefditoren concentrations equal to C(max) in the presence of 90% human serum or albumin at physiological concentrations...
  77. ncbi An outcome audit of the treatment of acute dentoalveolar infection: impact of penicillin resistance
    T Kuriyama
    Honorary Post doctoral Research Fellow, University Dental Hospital, Cardiff
    Br Dent J 198:759-63; discussion 754; quiz 778. 2005
    ..The aim of this audit was to measure the outcome of treatment of acute dentoalveolar infection and to determine if this was influenced by choice of antibiotic therapy or the presence of penicillin-resistance...
  78. ncbi Antibacterial use and Streptococcus pneumoniae penicillin resistance: A temporal relationship model
    Robertino M Mera
    Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Microb Drug Resist 12:158-63. 2006
    The nature of the temporal relationship between antibacterial consumption and Streptococcus pneumoniae penicillin resistance is investigated using population level data across time...
  79. pmc High protein binding and cidal activity against penicillin-resistant S. pneumoniae: a cefditoren in vitro pharmacodynamic simulation
    David Sevillano
    Microbiology Department, School of Medicine, Universidad Complutense, Madrid, Spain
    PLoS ONE 3:e2717. 2008
    ..Although protein binding is a reversible phenomenon, it is assumed that antibacterial activity is exclusively exerted by the free (unbound) fraction of antibiotics...
  80. ncbi The impact of penicillin resistance on short-term mortality in hospitalized adults with pneumococcal pneumonia: a systematic review and meta-analysis
    Imad M Tleyjeh
    Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Clin Infect Dis 42:788-97. 2006
    The clinical impact of penicillin resistance on the outcome of pneumococcal pneumonia has remained controversial...
  81. ncbi Influence of penicillin resistance on outcome in adult patients with invasive pneumococcal pneumonia: is penicillin useful against intermediately resistant strains?
    Vicenc Falco
    Infectious Disease Department, Hospitals Vall d Hebron, Universitat Autonoma de Barcelona, P degrees Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Antimicrob Chemother 54:481-8. 2004
    ..12-1 mg/L treated empirically during the first 48 h with beta-lactam antibiotics...
  82. ncbi Penicillin resistance and serotyping of Streptococcus pneumoniae in Latin America
    Paulo Camargos
    Department of Paediatrics, Medical School, Federal University of Minas Geraias, Avenida Alfredo Balena, 190 Room 4061, 30130 100 Belo Horizonte, and Respiratory Department, Hospital da Criança Santo Antônio, Porto Alegre, Brazil
    Paediatr Respir Rev 7:209-14. 2006
    ..Only 58% of the serotypes isolated in the region studied were represented in the seven-valent vaccine. Continual surveillance is essential to determine which formulation of conjugated vaccine will be suitable for use in Latin America...
  83. ncbi Bactericidal activity of amoxicillin against non-susceptible Streptococcus pneumoniae in an in vitro pharmacodynamic model simulating the concentrations obtained with the 2000/125 mg sustained-release co-amoxiclav formulation
    David Sevillano
    Microbiology Department, School of Medicine, Universidad Complutense, Madrid, Spain
    J Antimicrob Chemother 54:1148-51. 2004
    ....
  84. ncbi Trends of chromosomally mediated antimicrobial resistance in Neisseria gonorrhoeae in Canada: 1994-1999
    Lai King Ng
    National Microbial Laboratory, Population and Public Health Branch, Health Canada, Winnipeg, Manitoba, Canada
    Sex Transm Dis 30:896-900. 2003
    ..0 mg/L), tetracycline (MIC > or =2.0 mg/L and < or =8.0 mg/L), and erythromycin (MIC > or =2.0 mg/L)...
  85. ncbi High percentages of resistance to tetracycline and penicillin and reduced susceptibility to azithromycin characterize the majority of strain types of Neisseria gonorrhoeae isolates in Cuba, 1995-1998
    Jorge Sosa
    Instituto de Medicina Tropical Pedro Kouri, Havana, Cuba
    Sex Transm Dis 30:443-8. 2003
    ..The Gonococcal Antimicrobial Surveillance Program (GASP) in Cuba was established as part of a larger regional GASP program to facilitate the collection and reporting of antimicrobial susceptibility data for N gonorrhoeae isolates...
  86. ncbi Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany
    Ralf Rene Reinert
    Institute of Medical Microbiology, National Reference Center for Streptococci, University of Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Antimicrob Chemother 49:61-8. 2002
    ..Over the study period an increase in both macrolide and penicillin resistance was observed. The percentage of strains exhibiting reduced susceptibility to penicillin increased from 1...
  87. pmc Site-specific mutagenesis analysis of PBP 1A from a penicillin-cephalosporin-resistant pneumococcal isolate
    Anthony M Smith
    Respiratory and Meningeal Pathogens Research Unit, Department of Clinical Microbiology and Infectious Diseases, National Health Laboratory Service, Johannesburg, South Africa
    Antimicrob Agents Chemother 47:387-9. 2003
    ..Our data reveal that mutations at amino acid positions 574 to 577 and position 539 cause penicillin and cefotaxime resistance...
  88. ncbi Frequency of penicillin-resistant pneumococci in children is correlated to community utilization of antibiotics
    E Melander
    Clinical Microbiology Laboratory, Lund University Hospital, Sweden
    Pediatr Infect Dis J 19:1172-7. 2000
    ..To study the impact of the utilization of antibiotics in children at the population level on the frequency of penicillin-nonsusceptible pneumococci (PNSP)...
  89. ncbi A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae
    E Guenzi
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Mol Microbiol 12:505-15. 1994
    b>Penicillin resistance in Streptococcus pneumoniae has been attributed so far to the production of penicillin-binding protein (PBP) variants with decreased affinities for beta-lactam antibiotics...
  90. ncbi Measuring and interpreting associations between antibiotic use and penicillin resistance in Streptococcus pneumoniae
    M Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 32:1044-54. 2001
    ..Recommendations for the design and analysis of future studies of antibiotic treatment and pneumococcal resistance are proposed...
  91. pmc Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997 98
    G V Doern
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA
    Emerg Infect Dis 5:757-65. 1999
    ..Resistance to all 10 ss-lactam drugs examined in this study was directly related to the level of penicillin resistance. Penicillin resistance rates were highest in isolates from middle ear fluid and sinus aspirates of ..
  92. ncbi Impaired bacteriologic response to oral cephalosporins in acute otitis media caused by pneumococci with intermediate resistance to penicillin
    R Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
    Pediatr Infect Dis J 15:980-5. 1996
    b>Penicillin resistance of Streptococcus pneumoniae, one of the most common causes of acute otitis media, has recently increased and is now highly prevalent in many regions...
  93. ncbi Six year multicenter surveillance of invasive pneumococcal infections in children
    Sheldon L Kaplan
    Pediatric Infectious Diseases Sections, Baylor College of Medicine, Houston, TX, USA
    Pediatr Infect Dis J 21:141-7. 2002
    ..Monitor clinical and microbiologic features including antimicrobial susceptibility of invasive pneumococcal infections among children...
  94. ncbi The role of murMN operon in penicillin resistance and antibiotic tolerance of Streptococcus pneumoniae
    S R Filipe
    Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA
    Microb Drug Resist 7:303-16. 2001
    ..The purpose of studies described in this communication was to understand better the role of murMN in penicillin resistance. Deletion of murM in the penicillin-resistant strain Pen6, which causes reduction in the penicillin MIC ..
  95. pmc Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
    Patricia A Ropp
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7365, USA
    Antimicrob Agents Chemother 46:769-77. 2002
    Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability...
  96. pmc Laboratory survey of drug-resistant Streptococcus pneumoniae in New York City, 1993-1995
    R Heffernan
    New York City Department of Health, New York, USA
    Emerg Infect Dis 4:113-6. 1998
    ..This survey of hospital microbiology laboratories in New York City found that penicillin resistance (MIC > or = 2.0 micrograms/ml) increased from 1.5% of S. pneumoniae isolates in 1993 to 6...
  97. pmc Clonal dissemination of macrolide-resistant and penicillin-susceptible serotype 3 and penicillin-resistant Taiwan 19F-14 and 23F-15 Streptococcus pneumoniae isolates in Japan: a pilot surveillance study
    Kei Kasahara
    Second Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara City, Nara 634 8522, Japan
    J Clin Microbiol 43:1640-5. 2005
    ..Based on the results of our pilot study performed in a single institution, it is likely that international antibiotic-resistant clones have already spread in Japan; therefore, a nationwide surveillance study should be urgently conducted...
  98. ncbi Streptococcus pneumoniae: bacteremia in an era of penicillin resistance
    E M Castillo
    Master of Public Health Program Epidemiology, San Diego State University, California, USA
    Am J Infect Control 28:239-43. 2000
    ..CONCLUSION: With the increase in S pneumoniae resistance to penicillin, it is important to continue surveillance of infections caused by S pneumoniae. Hospital-based studies are useful for tracking epidemiologically important pathogens...
  99. ncbi Molecular characterization of penicillin non-susceptible Streptococcus pneumoniae in Christchurch, New Zealand
    David C Bean
    Centre for Infectious Disease, Barts and the London School of Medicine and Dentistry, Queen Mary College, University of London, London E1 2AD, UK
    J Antimicrob Chemother 54:122-9. 2004
    ..To determine the epidemiological relationship between non-invasive penicillin non-susceptible Streptococcus pneumoniae isolates collected in the Christchurch community between 1997 and 2001...
  100. pmc Phenotypic and genetic diversity of invasive pneumococcal isolates recovered from French children
    Catherine Doit
    Service de Microbiologie, Hopital Robert Debre, Paris, France
    J Clin Microbiol 40:2994-8. 2002
    ..Although some serotypes were recovered more frequently from children with bacteremia than from those with meningitis, no difference in the genetic backgrounds of the two groups of strains was found...
  101. ncbi Clinical and microbiological epidemiology of Streptococcus pneumoniae bacteremia in eight French counties
    J Maugein
    Hopital Haut Leveque, Pessac, France
    Clin Microbiol Infect 9:280-8. 2003
    ....

Research Grants31

  1. ArmR: a novel drug target and mediator of antibiotic resistance
    David S Weiss; Fiscal Year: 2013
    ..aimed at reversing resistance, in much the same way that beta-lactamase inhibitors can counteract penicillin resistance. To this end, we have recently identified a novel protein that we have named ArmR (or "Armor" - ..
  2. PENICILLIN RESPONSE GENES IN DRUG-RESISTANT PNEUMOCOCCI
    Alexander Tomasz; Fiscal Year: 1999
    ..the molecular basis of beta-lactam antibiotic resistance; the mechanism(s) that control the level (MIC) of penicillin resistance and the origin and nature of genetic elements that define the complex pleiomorphic phenotypes of these ..
  3. WHOLE GENOME SHOTGUN SEQUENCING OF STREPTOCOCCUS MITIS
    Herve Tettelin; Fiscal Year: 2001
    ..mitis type strain constitutes a reservoir of genetic determinants that contribute to penicillin resistance in pathogenic S. pneumoniae...
  4. VACCINE EFFICACY IN CHILDREN WITH SICKLE CELL DISEASE
    Thomas Adamkiewicz; Fiscal Year: 2006
    ..This rapid increase in penicillin resistance warrants evaluation of more effective prophylaxis of S...
  5. STREPTOCOCCUS SANGUIS MICROBIAL GENOME PROJECT
    FRANCIS MACRINA; Fiscal Year: 2002
    ..And such infections are being compounded by the increasing frequency with which penicillin resistance is being observed in this group of organisms...
  6. Antibiotic Resistance in the Oral Streptococci
    Jeffrey Rogers; Fiscal Year: 2003
    ..The contribution of such mosaic genes to the emergence of penicillin resistance is widely accepted...
  7. PREVENTION OF PNEUMOCOCCAL DISEASE IN HIV INFECTION
    MARY MCELLISTREM; Fiscal Year: 2004
    ..All patients who exhibit a greater that 3-fold transient rise in HIV-1 RNA levels 2 and 4 weeks postimmunization will be evaluated by Fisher's Exact and McNemar's Tests. ..
  8. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
    ..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
  9. Hospital-Acquired Infections in the Elderly
    Keith Kaye; Fiscal Year: 2008
    ..The risk factor identified for SSI and MDRB and the impact of SSI and MDRB on health outcomes will be used to design and implement future preventive interventions. ..
  10. RCT to evaluate guidelines for acute rhinosinusitis
    Jane Garbutt; Fiscal Year: 2008
    ..In addition, knowledge gained from this research could be used to decrease the inappropriate use of antibiotics. [unreadable] [unreadable]..
  11. New Nosocomial Interventions to Decrease Antimicrobial Resistance Transmission
    Anthony Harris; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. DEVELOPMENT OF STAPHYLOCOCCALCIDAL HUMAN PEPTIDES
    William Shafer; Fiscal Year: 2008
    ..This information should help in the development of new effective peptide-based drugs that could be used in the future to combat staphylococcal diseases caused by antibiotic-resistant strains. ..
  13. 2009 Multi-drug Efflux Systems Gordon Research Conference
    William Shafer; Fiscal Year: 2008
    ..The GRC will focus on these specific key areas related to multi-drug efflux pumps in resistance. [unreadable] [unreadable] [unreadable]..
  14. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..
  15. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  16. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  17. Novel Targets for Treatment of Pseudomonas aeruginosa
    Philip Lister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  18. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  19. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  20. LTQ Orbitrap tandem mass spectrometer
    Catherine Fenselau; Fiscal Year: 2007
    ..This commercially available, technologically sophisticated instrument will support meritorious projects on a shared use, highly cost-effective basis, and foster multidisciplinary interaction. [unreadable] [unreadable] [unreadable]..
  21. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
  22. Epidemiologic Methods: Resistant Nosocomial Infections
    Marc Lipsitch; Fiscal Year: 2004
    ..This will in turn lead to better practices to reduce the incidence of ARNI. ..
  23. In Situ Detection of Host-Spirochete Interaction by Iso*
    Ruth Montgomery; Fiscal Year: 2002
    ..burgdorferi. In summary, this proposal employs a novel and powerful technique to address several possible mechanisms of spirochetal evasion of the immune system. ..
  24. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  25. A Zeiss LSM 510 Confocal Microscope for Medical Research
    Ruth Montgomery; Fiscal Year: 2004
    ..Thus this confocal microscope would be the basis of a core facility to assure that these investigators will have adequate access to state-of-the-art imaging techniques. ..
  26. PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 2003
    ..To augment information about where PBPs localize, when they are expressed during the cell cycle will be determined by Northern blotting. ..
  27. GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINS
    William Shafer; Fiscal Year: 2009
    ..abstract_text> ..
  28. Sexually Transmitted Infections & Antimicrobial Peptides
    William Shafer; Fiscal Year: 2009
    ..abstract_text> ..
  29. Mechanism of Vector Saliva Inhibition of Innate Immunity
    Ruth Montgomery; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..