beta lactam resistance

Summary

Summary: Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.

Top Publications

  1. pmc Molecular epidemiology of the integron-located VEB-1 extended-spectrum beta-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand
    D Girlich
    , , , , , France
    J Clin Microbiol 39:175-82. 2001
  2. ncbi International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections
    David L Paterson
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Ann Intern Med 140:26-32. 2004
  3. pmc Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals
    Laura Brinas
    Área de Bioquímica y Biología Molecular, Universidad de La Rioja, 26006 Logrono, Spain
    Antimicrob Agents Chemother 46:3156-63. 2002
  4. ncbi Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates
    Paul D Stapleton
    Microbiology Group, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Int J Antimicrob Agents 23:462-7. 2004
  5. pmc Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18
    J K Rasheed
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 44:2382-8. 2000
  6. pmc Spread of Escherichia coli strains with high-level cefotaxime and ceftazidime resistance between the community, long-term care facilities, and hospital institutions
    Jesús Oteo
    Antibiotic Laboratory, Bacteriology Service, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Pozuelo a Majadahonda, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 44:2359-66. 2006
  7. ncbi Antibiotic rotation and development of gram-negative antibiotic resistance
    Harald J van Loon
    Department of Surgery, Eijkman Winkler Institute for Microbiology, Infectious Disease and Inflammation, University Medical Center Utrecht, Heidelberglaan 100, PO Box 3508 GA, Utrecht, The Netherlands
    Am J Respir Crit Care Med 171:480-7. 2005
  8. pmc Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15
    Teresa M Coque
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Emerg Infect Dis 14:195-200. 2008
  9. pmc High prevalence of CTX-M-15-producing Klebsiella pneumoniae among inpatients and outpatients with urinary tract infection in Southern India
    - Muzaheed
    J Antimicrob Chemother 61:1393-4. 2008
  10. ncbi Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus
    Daniel Lim
    2146 Health Sciences Mall, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Struct Biol 9:870-6. 2002

Detail Information

Publications192 found, 100 shown here

  1. pmc Molecular epidemiology of the integron-located VEB-1 extended-spectrum beta-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand
    D Girlich
    , , , , , France
    J Clin Microbiol 39:175-82. 2001
    ..Plasmid- and integron-mediated resistance to rifampin was also found in enterobacterial isolates...
  2. ncbi International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections
    David L Paterson
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Ann Intern Med 140:26-32. 2004
    ..Commonly encountered nosocomially acquired gram-negative bacteria, especially Klebsiella pneumoniae, produce extended-spectrum beta-lactamases (ESBLs) as an antibiotic resistance mechanism...
  3. pmc Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals
    Laura Brinas
    Área de Bioquímica y Biología Molecular, Universidad de La Rioja, 26006 Logrono, Spain
    Antimicrob Agents Chemother 46:3156-63. 2002
    ..Different variants of bla(TEM-1) and IRT bla(TEM) genes were found among the AMP(r) E. coli isolates from foods and the feces of humans and healthy animals, and a new gene, bla(TEM-95b) (P3), was detected...
  4. ncbi Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates
    Paul D Stapleton
    Microbiology Group, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Int J Antimicrob Agents 23:462-7. 2004
    ..Consequently, EGCG, CG and, particularly, ECG warrant further investigation as agents to combat beta-lactam resistance in S. aureus...
  5. pmc Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18
    J K Rasheed
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 44:2382-8. 2000
    ..In addition to the production of this novel ESBL, designated SHV-18, analysis of the outer membrane proteins of K6 revealed the loss of the OmpK35 and OmpK37 porins...
  6. pmc Spread of Escherichia coli strains with high-level cefotaxime and ceftazidime resistance between the community, long-term care facilities, and hospital institutions
    Jesús Oteo
    Antibiotic Laboratory, Bacteriology Service, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Pozuelo a Majadahonda, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 44:2359-66. 2006
    ..Epidemic or occasional isolates of cefotaxime- and ceftazidime-resistant E. coli can spread between distinct health facilities including hospitals, community health centers, and long-term care centers...
  7. ncbi Antibiotic rotation and development of gram-negative antibiotic resistance
    Harald J van Loon
    Department of Surgery, Eijkman Winkler Institute for Microbiology, Infectious Disease and Inflammation, University Medical Center Utrecht, Heidelberglaan 100, PO Box 3508 GA, Utrecht, The Netherlands
    Am J Respir Crit Care Med 171:480-7. 2005
    ..Cycling of homogeneous antibiotic exposure is unlikely to control the emergence of gram-negative antimicrobial resistance in intensive care units...
  8. pmc Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15
    Teresa M Coque
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Emerg Infect Dis 14:195-200. 2008
    ..Most plasmids contained blaOXA-1, aac(6')-Ib-cr, and blaTEM-1. Worldwide dissemination of CTX-M-15 seems to be determined by clonal complexes ST131 and ST405 and multidrug-resistant IncFII plasmids...
  9. pmc High prevalence of CTX-M-15-producing Klebsiella pneumoniae among inpatients and outpatients with urinary tract infection in Southern India
    - Muzaheed
    J Antimicrob Chemother 61:1393-4. 2008
  10. ncbi Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus
    Daniel Lim
    2146 Health Sciences Mall, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Struct Biol 9:870-6. 2002
    ..An analysis of the PBP2a active site in these forms reveals the structural basis of its resistance and identifies features in newly developed beta-lactams that are likely important for high affinity binding...
  11. pmc Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection
    Simona Bratu
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New Yoek 11203, USA
    Antimicrob Agents Chemother 49:3018-20. 2005
    ..pneumoniae, particular attention should be paid to proper inoculum preparation for broth-based susceptibility methods. In addition, using ertapenem or meropenem for class reporting of carbapenem susceptibility will improve detection...
  12. pmc Replicon typing of plasmids encoding resistance to newer beta-lactams
    Alessandra Carattoli
    Department of Infectious, Parasituc, Immune Mediated diseases, Istituto Superiore di Sanita, Rome, Italy
    Emerg Infect Dis 12:1145-8. 2006
    ....
  13. ncbi Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, South Paris Medical School, University Paris XI, Le Kremlin Bicetre, France
    Clin Microbiol Infect 12:826-36. 2006
    ..baumannii may also result from porin or penicillin-binding protein modifications. Several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx of carbapenems, might be involved in carbapenem resistance...
  14. ncbi Penicillin-binding proteins and beta-lactam resistance
    André Zapun
    Laboratoire d Ingénierie des Macromolécules, Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075 CNRS, CEA, Universite Joseph Fourier, Grenoble, France
    FEMS Microbiol Rev 32:361-85. 2008
    ....
  15. pmc Dissemination and persistence of blaCTX-M-9 are linked to class 1 integrons containing CR1 associated with defective transposon derivatives from Tn402 located in early antibiotic resistance plasmids of IncHI2, IncP1-alpha, and IncFI groups
    Angela Novais
    Hospital Universitario Ramon y Cajal, IMSALUD, Madrid 28034, Spain
    Antimicrob Agents Chemother 50:2741-50. 2006
    ..The presence of bla(CTX-M-9) on broad-host-range IncP-1alpha plasmids might contribute to its dissemination to hosts that were not members of the family Enterobacteriaceae...
  16. pmc Risk factors for colonization with extended-spectrum beta-lactamase-producing bacteria and intensive care unit admission
    Anthony D Harris
    Department of Epidemiology and Preventive Medicine, School of Medicine, University of Maryland, Baltimore 21201, USA
    Emerg Infect Dis 13:1144-9. 2007
    ..15; 95% CI 1.04-1.27). Coexisting conditions and previous antimicrobial drug exposure are thus predictive of colonization, and a large percentage of these patients have subsequent positive clinical cultures for ESBL-producing bacteria...
  17. pmc Distribution of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in Vietnam
    Van Cao
    Unite des Agents Antibacteriens, Institut Pasteur, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 46:3739-43. 2002
    ..Molecular typing of the strains with a similar resistance phenotype to broad-spectrum cephalosporins indicated polyclonal spread. ISEcp1 was presumably responsible for dissemination of the bla(CTX-M-like) gene...
  18. pmc Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides
    A Rosenau
    Département de Microbiologie Médicale et Moléculaire, Centre Hospitalier Universitaire Bretonneau, 37044 Tours Cedex, France
    Antimicrob Agents Chemother 44:760-2. 2000
    ....
  19. pmc Antimicrobial drug use and antibiotic-resistant bacteria
    Fernando Bellissimo-Rodrigues
    Emerg Infect Dis 14:187; author reply,187-8. 2008
  20. ncbi Acquired metallo-beta-lactamases: an increasing clinical threat
    Gian Maria Rossolini
    Clin Infect Dis 41:1557-8. 2005
  21. pmc Metallo-beta-lactamases: the quiet before the storm?
    Timothy R Walsh
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Clin Microbiol Rev 18:306-25. 2005
    ..Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-beta-lactamase inhibitor studies securing the longevity of important anti-infectives...
  22. pmc Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 52:1252-6. 2008
    ..Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla OXA-23 gene...
  23. ncbi Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum beta-lactamase CTX-M-15 and of its structurally related beta-lactamase CTX-M-3
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    J Antimicrob Chemother 50:1031-4. 2002
    ..This work underlines the fact that some CTX-M enzymes may hydrolyse ceftazidime and thus confer resistance to this expanded-spectrum cephalosporin in Enterobacteriaceae...
  24. pmc Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia
    M P Crespo
    Group of Medical Microbiology and Infectious Diseases, Universidad Santiago de Cali, Colombia
    J Clin Microbiol 42:5094-101. 2004
    ....
  25. pmc Clonal dissemination of a CTX-M-15 beta-lactamase-producing Escherichia coli strain in the Paris area, Tunis, and Bangui
    M Lavollay
    Laboratoire de Bacteriologie, UPRES EA 2392, Faculte de Medecine Pierre et Marie Curie, Universite Paris VI, Paris, France
    Antimicrob Agents Chemother 50:2433-8. 2006
    ..coli clone with a strong propensity for dissemination...
  26. ncbi Resistance to beta-lactam antibiotics
    K Poole
    Department of Microbiology and Immunology, Queen s University, K7L 3N6, Kingston, Ontario, Canada
    Cell Mol Life Sci 61:2200-23. 2004
    ....
  27. ncbi The new beta-lactamases
    George A Jacoby
    Department of Infectious Diseases, Lahey Clinic, Burlington, Mass 01805, USA
    N Engl J Med 352:380-91. 2005
  28. pmc Role of ampD homologs in overproduction of AmpC in clinical isolates of Pseudomonas aeruginosa
    Amber J Schmidtke
    Department of Medical Microbiology and Immunology, Center for Research in Anti Infectives and Biotechnology, Creighton University, Omaha, Nebraska 68178, USA
    Antimicrob Agents Chemother 52:3922-7. 2008
    ..Overall, the findings of the present study indicate that there is still an unknown factor(s) that contributes to ampC regulation in P. aeruginosa...
  29. ncbi Plasmid-borne AmpC beta-lactamases
    Jan Walther-Rasmussen
    Department of Clinical Microbiology, Rigshospitalet, National University Hospital, Copenhagen, Denmark
    Can J Microbiol 48:479-93. 2002
    ..This review discusses the phylogenetic origin of the plasmid-encoded AmpC beta-lactamases, their occurrence, and mode of spread, as well as their hydrolytic properties...
  30. pmc Dissemination of CTX-M-15 beta-lactamase genes carried on Inc FI and FII plasmids among clinical isolates of Escherichia coli in a university hospital in Istanbul, Turkey
    Nevriye Gonullu
    Department of Microbiology and Clinical Microbiology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul 34303, Turkey
    J Clin Microbiol 46:1110-2. 2008
    ..Plasmid typing of transconjugates carrying bla(CTX-M-15) showed that most isolates belonged to the Inc/rep FII group but that one isolate also belonged to the FI group...
  31. pmc Accuracy of three automated systems (MicroScan WalkAway, VITEK, and VITEK 2) for susceptibility testing of Pseudomonas aeruginosa against five broad-spectrum beta-lactam agents
    Helio S Sader
    JMI Laboratories, Inc, 345 Beaver Kreek Centre, Suite A, North Liberty, Iowa 52317, USA
    J Clin Microbiol 44:1101-4. 2006
    ..aeruginosa that exhibit contemporary resistance mechanisms would be prudent to minimize the potential for serious reporting errors...
  32. pmc VEB-1 Extended-spectrum beta-lactamase-producing Acinetobacter baumannii, France
    Thierry Naas
    Department of Bacteriology and Virology, Hopital de Bicetre, 73 rue du Général Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Emerg Infect Dis 12:1214-22. 2006
    ..The national alert enabled early control of new clusters, demonstrating the usefulness of early warning about antimicrobial drug resist...
  33. ncbi Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals
    Young Kyoung Park
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440 746, Korea
    Diagn Microbiol Infect Dis 64:389-95. 2009
    ..The distribution of these main carbapenem-resistant A. baumannii clones did not relate to locality, indicating that they are widespread in Korean hospitals. In addition, we found new types of PER beta-lactamases, PER-6...
  34. ncbi Solution structural study of BlaI: implications for the repression of genes involved in beta-lactam antibiotic resistance
    Hélène Van Melckebeke
    Institut de Biologie Structurale Jean Pierre Ebel, CEA CNRS UJF, 41 Avenue Jules Horowitz, 38027, Grenoble Cedex 1, France
    J Mol Biol 333:711-20. 2003
    ..These results help toward understanding the repression and induction mechanism of the genes coding for beta-lactamase and PBP2'...
  35. pmc The beta-lactam-resistance modifier (-)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureus
    Paul D Stapleton
    Microbiology Group, School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    Microbiology 153:2093-103. 2007
    ..Thus, ECg-mediated alterations to the physical nature of the bilayer will elicit structural changes to WTA that result in modulation of the cell-surface properties necessary to maintain the beta-lactam-resistant phenotype...
  36. ncbi Carbapenemases: a problem in waiting?
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, NW9 5HT, London, UK
    Curr Opin Microbiol 3:489-95. 2000
    ..Is the emergence of carbapenemase a problem waiting to happen?..
  37. pmc Outbreak of carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-23 in a tertiary care hospital of Papeete, French Polynesia
    Thierry Naas
    Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    J Clin Microbiol 43:4826-9. 2005
    ..This study further illustrates the global spread of this kind of beta-lactamase-mediated resistance...
  38. ncbi Emerging epidemic of metallo-beta-lactamase-mediated resistances
    Ronald N Jones
    Diagn Microbiol Infect Dis 51:77-84. 2005
  39. ncbi Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-beta-lactamase
    G Cornaglia
    1Istituto di Microbiologia, Universita di Verona, Verona, Italy
    Clin Infect Dis 31:1119-25. 2000
    ..These findings emphasize the need for early recognition of similar isolates...
  40. pmc Prevalence of newer beta-lactamases in gram-negative clinical isolates collected in the United States from 2001 to 2002
    Ellen S Moland
    Department of Medical Microbiology and Immunology, Center for Research in Anti Infectives and Biotechnology, CRAB, School of Medicine, Creighton University Medical Center, 2500 California Plaza, Omaha, NE 68178, USA
    J Clin Microbiol 44:3318-24. 2006
    ..In conclusion, organisms producing ESBLs and transferable AmpC beta-lactamases were widespread. Clinical laboratories must be able to detect important beta-lactamases to ensure optimal patient care and infection control...
  41. pmc In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette
    M L Riccio
    Dipartimento di Biologia Molecolare, Sezione di Microbiologia, , I-53100 Siena, Italy
    Antimicrob Agents Chemother 45:1249-53. 2001
    ..In70, with its array of cassette-borne resistance genes, can mediate broad-spectrum resistance to most beta-lactams and aminoglycosides...
  42. pmc Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains
    Carlos Juan
    Servicio de Microbiologia, Hospital Son Dureta, C Andrea Doria No 55, 07014 Palma de Mallorca, Spain
    Antimicrob Agents Chemother 49:4733-8. 2005
    ....
  43. ncbi Cross-class resistance to non-beta-lactam antimicrobials in extended-spectrum beta-lactamase-producing Klebsiella pneumoniae
    Gary W Procop
    Section of Clinical Microbiology, Department of Clinical Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Clin Pathol 120:265-7. 2003
    ..001). All isolates were susceptible to imipenem. ESBL-producing K pneumoniae may also be resistant to non-beta-lactam antibiotics. Therefore, susceptibility testing of these isolates is critical for guiding therapy...
  44. ncbi Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases
    David L Paterson
    Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 39:31-7. 2004
    ..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae...
  45. pmc CTX-M beta-lactamase-producing Escherichia coli in long-term care facilities, France
    Najjiby Kassis-Chikhani
    Emerg Infect Dis 10:1697-8. 2004
  46. ncbi Carbapenem-resistant and OXA-23-producing Acinetobacter baumannii isolates in the United Arab Emirates
    P Mugnier
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, Bicetre, France
    Clin Microbiol Infect 14:879-82. 2008
    ..The single non-clonally related isolate harboured the bla(OXA-23) gene on a 70-kb transferable plasmid. This study reports on the dissemination of OXA-23-producing A. baumannii isolates in the Middle East...
  47. pmc A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital
    Raffaele Zarrilli
    Dipartimento di Scienze Mediche Preventive, Universita di Napoli Federico II, Napoli, Italy
    Antimicrob Agents Chemother 52:4115-20. 2008
    ..The production of the carbapenem-hydrolyzing oxacillinase OXA-58 was apparently the only mechanism for carbapenem resistance in A. baumannii isolates causing the outbreak at the Lebanese Hospital...
  48. pmc Benefit of having multiple ampD genes for acquiring beta-lactam resistance without losing fitness and virulence in Pseudomonas aeruginosa
    Bartolome Moya
    Servicio de Microbiologia, Hospital Son Dureta, Palma de Mallorca, Spain
    Antimicrob Agents Chemother 52:3694-700. 2008
    ..aeruginosa. Therefore, as a consequence of the presence of additional ampD genes, partial ampC derepression mediated by ampD inactivation confers a biologically efficient resistance mechanism on P. aeruginosa...
  49. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
  50. ncbi Clonal spread of carbapenem-resistant OXA-23-positive Acinetobacter baumannii in a Bulgarian university hospital
    T Stoeva
    Department of Microbiology and Virology, Medical University, Varna, Bulgaria
    Clin Microbiol Infect 14:723-7. 2008
    ..The isolates belonged to two different clonal groups, indicating a sustained hospital outbreak. This study demonstrates both the epidemic potential of carbapenem-resistant A. baumannii and its longevity in the hospital environment...
  51. pmc Pseudo-outbreak of imipenem-resistant Acinetobacter baumannii resulting from false susceptibility testing by a rapid automated system
    A Tsakris
    Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Clin Microbiol 38:3505-7. 2000
    ..The pseudoresistant acinetobacters did not form a genetically homogeneous group. It is suggested that the detection of imipenem-resistant A. baumannii isolates by this system should be confirmed by an additional susceptibility test...
  52. ncbi First report of CTX-M-15 and CTX-M-3 beta-lactamases among clinical isolates of Enterobacteriaceae in Béjaia, Algeria
    Abdelaziz Touati
    Laboratoire de Microbiologie Appliquée, FSNV, Université A MIRA de Béjaia 06000, Algeria
    Int J Antimicrob Agents 27:397-402. 2006
    ..The bla(CTX-M-15) genes were transferred from E. coli by conjugation, whilst conjugative transfer of bla(CTX-M) genes from K. pneumoniae and E. cloacae was not detectable...
  53. ncbi Detection of beta-lactamase-mediated resistance
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK
    J Antimicrob Chemother 48:59-64. 2001
    ....
  54. pmc Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR
    F Javier Pérez-Pérez
    Center for Research in Anti Infectives and Biotechnology, Department of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, Nebraska 68178, USA
    J Clin Microbiol 40:2153-62. 2002
    ..In conclusion, a multiplex PCR technique was developed for identifying family-specific ampC genes responsible for AmpC beta-lactamase expression in organisms with or without a chromosomal AmpC beta-lactamase gene...
  55. ncbi Characterization of acquired beta-lactamases and their genetic support in multidrug-resistant Pseudomonas aeruginosa isolates in Taiwan: the prevalence of unusual integrons
    Jing Jou Yan
    Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Antimicrob Chemother 58:530-6. 2006
    ..The present study was conducted to investigate acquired beta-lactamases and their genetic support in 26 Pseudomonas aeruginosa isolates that were resistant to nearly all antipseudomonal drugs from six medical centres in Taiwan...
  56. pmc Stepwise upregulation of the Pseudomonas aeruginosa chromosomal cephalosporinase conferring high-level beta-lactam resistance involves three AmpD homologues
    Carlos Juan
    Servicio de Microbiologia, Hospital Son Dureta, C Andrea Doria No 55, 07014 Palma de Mallorca, Spain
    Antimicrob Agents Chemother 50:1780-7. 2006
    ....
  57. ncbi Investigation of a nosocomial outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a hospital setting
    A Carbonne
    Centre inter régional de lutte contre l infection nosocomiale C CLIN Nord, Institut des Cordeliers, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Hosp Infect 60:14-8. 2005
    ..A case-control study identified previous treatment with third-generation cephalosporins as the only risk factor for A. baumannii acquisition. Rationale for antibiotic use should be strengthened...
  58. ncbi Clinically significant carbapenemases: an update
    Timothy R Walsh
    Department of Medical Microbiology, School of Medical Sciences, Cardiff University, Heath Park Hospital, Cardiff, UK
    Curr Opin Infect Dis 21:367-71. 2008
    ..To provide a brief synopsis of studies which have extended our understanding of carbapenem resistance in clinical isolates in terms of epidemiology, mechanism of action and genetic factors affecting their carriage and spread...
  59. ncbi Spread of novel expanded-spectrum beta-lactamases in Enterobacteriaceae in a university hospital in the Paris area, France
    M F Lartigue
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Clin Microbiol Infect 11:588-91. 2005
    ..coli, two Enterobacter cloacae, one Enterobacter aerogenes, one Proteus mirabilis and one Citrobacter freundii). Other ESBLs, such as VEB-1 and PER-1, were also detected, but less frequently...
  60. ncbi A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococci
    H Z Zhang
    Division of Infectious Diseases, San Francisco General Hospital, Department of Medicine, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Science 291:1962-5. 2001
    ..Compounds that disrupt this regulatory pathway could restore the activity of beta-lactam antibiotics against drug-resistant strains of staphylococci...
  61. ncbi Emergence of PER and VEB extended-spectrum beta-lactamases in Acinetobacter baumannii in Belgium
    Thierry Naas
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Université Paris XI 78 rue du Général Leclerc, 94275 K Bicêtre, France
    J Antimicrob Chemother 58:178-82. 2006
    ..Here we describe the emergence of strains of A. baumannii producing VEB-1 and PER- 1 in Belgium...
  62. pmc Beta-lactam resistance and Enterobacteriaceae, United States
    Jean M Whichard
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1464-6. 2005
    ..2% (44/1,378) contained blaCMY genes. Novel findings included blaCMY-positive Escherichia coli O157:H7 and a blaSHV-positive Salmonella isolate. CMY-positive isolates showed a ceftriaxone MIC > or =2 microg/mL...
  63. ncbi Factors associated with cure after therapy of clinical mastitis caused by Staphylococcus aureus
    J Sol
    Animal Health Service, Deventer, The Netherlands
    J Dairy Sci 83:278-84. 2000
    ..The seriousness of the various clinical symptoms and the bacteriological cure rate of clinical S. aureus mastitis were not associated...
  64. pmc Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7)
    Alan Patrick Gibb
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Antimicrob Agents Chemother 46:255-8. 2002
    ..They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer...
  65. pmc Discovery of CTX-M-like extended-spectrum beta-lactamases in Escherichia coli isolates from five US States
    E Smith Moland
    Antimicrob Agents Chemother 47:2382-3. 2003
  66. ncbi [Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in spanish hospitals (GEIH-BLEE Project 2002)]
    José Ramón Hernández
    Servicio de Microbiología Hospital Universitario Virgen de la Macarena Sevilla Spain
    Enferm Infecc Microbiol Clin 21:77-82. 2003
    ..To describe demographic aspects of a prospective multicentric nationwide study on Escherichia coli and Klebsiella pneumoniae producing extended spectrum b -lactamases (ESBL) in Spain, between March and June 2000...
  67. pmc Trends in production of extended-spectrum beta-lactamases among enterobacteria of medical interest: report of the second Italian nationwide survey
    Francesco Luzzaro
    Laboratory of Medical Microbiology, Università dell Insubria and Ospedale di Circolo e Fondazione Macchi, Viale Borri, 57 21100 Varese, Italy
    J Clin Microbiol 44:1659-64. 2006
    ..The appearance of ESBL-positive enterobacteria in the community makes it mandatory that family physicians learn how to treat these pathogens...
  68. pmc Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 41:563-9. 1997
    ..pneumoniae when a high level of the ACT-1 beta-lactamase is produced in combination with the loss of a major outer membrane protein...
  69. pmc Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia
    J K Rasheed
    Nosocomial Pathogens Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 41:647-53. 1997
    ..This collection of blood isolates from the same patient appears to represent the in vivo evolution of resistance under selective pressure of treatment with various cephalosporins...
  70. ncbi Molecular mechanisms of cefoxitin resistance in Escherichia coli from the Toronto area hospitals
    K R Forward
    Dalhousie University, Halifax, Nova Scotia, Canada
    Diagn Microbiol Infect Dis 41:57-63. 2001
    ..The majority of cephamycin resistant E. coli strains in Toronto have attenuator and/or promotor mutations upstream of the chromosomal ampC gene...
  71. ncbi Alterations in high molecular mass penicillin-binding protein 1 associated with beta-lactam resistance in Shigella dysenteriae
    A S Ghosh
    Department of Chemistry, Bose Institute, Calcutta, India
    Biochem Biophys Res Commun 248:669-72. 1998
    ..e. 1' + 1") in the mutant M19 compared to C152. This is the first report which presents evidence of the involvement of altered high molecular mass PBPs in beta-lactam resistance in S. dysenteriae...
  72. ncbi Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium
    Simona Bratu
    Division of Infectious Diseases, State University of New York Downstate, Brooklyn, NY 11203, USA
    Arch Intern Med 165:1430-5. 2005
    ..In this study, the prevalence and molecular epidemiologic characteristics of carbapenem-resistant K pneumoniae are analyzed, and the experience involving 2 hospital outbreaks is described...
  73. ncbi Extended-spectrum beta-lactamases
    J E Patterson
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Semin Respir Infect 15:299-307. 2000
    ..In addition, because this type of antimicrobial resistance appears to be particularly influenced by antibiotic use, antibiotic control measures may also be a very important intervention in controlling the spread of ESBLs...
  74. ncbi Comparative in vitro activity of ertapenem against extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated in Spain
    Jose R Hernandez
    Department of Microbiology, Faculty of Medicine, University of Seville, Av Sánchez Pizjuán S N, 41009 Seville, Spain
    Int J Antimicrob Agents 28:457-9. 2006
    ..Ertapenem activity was similar to that of imipenem and meropenem and better than that of the other antimicrobials tested. No differences in activity were observed regarding the origin of the isolates or type of ESBL produced...
  75. ncbi Extended-spectrum beta-lactamases in ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae isolates in Turkish hospitals
    S Hosoglu
    Department of Infectious Diseases and Clinical Microbiology, Dicle University Hospital, Diyarbakir, Turkey
    Indian J Med Microbiol 25:346-50. 2007
    ..To study the prevalence of TEM-, SHV- and GES-type beta -lactamases among Escherichia coli and Klebsiella pneumoniae strains having ceftazidime MICs higher than 2 mg/L...
  76. ncbi Outbreak of carbapenem-resistant Klebsiella pneumoniae producing KPC-3 in a tertiary medical centre in Israel
    Zmira Samra
    Laboratory of Clinical Microbiology, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa 49100, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Antimicrob Agents 30:525-9. 2007
    ..These findings should alert government and medical authorities to institute stringent control measures and to initiate research into therapeutic and preventive strategies...
  77. ncbi Defining an extended-spectrum beta-lactamase
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, London, UK
    Clin Microbiol Infect 14:3-10. 2008
    ..It seems best-and pragmatic-that the term 'ESBL' retains its broad modern usage, but that should always be accompanied by mention of the enzyme's family as, e.g., in 'TEM ESBL' or 'OXA ESBL', not as a sole moniker...
  78. ncbi In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase
    Eugenne Elliott
    Department of Clinical Microbiology, Ampath Laboratories, Milpark Hospital, Johannesburg, South Africa
    Clin Infect Dis 42:e95-8. 2006
    ..All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin...
  79. ncbi Breakpoints for extended-spectrum beta-lactamase-producing Enterobacteriacae: pharmacokinetic/pharmacodynamic considerations
    A MacGowan
    Department of Medical Microbiology, Bristol Centre for Antimicrobial Research and Evaluation, University of Bristol and North Bristol NHS Trust, Southmead Hospital, Westbury on Trym, Bristol, UK
    Clin Microbiol Infect 14:166-8. 2008
    ..Therefore, pharmacodynamic modelling can be used to set breakpoints for ESBL-producing bacteria with beta-lactams...
  80. pmc Prevalence of plasmid-mediated AmpC beta-lactamases in a Chinese university hospital from 2003 to 2005: first report of CMY-2-Type AmpC beta-lactamase resistance in China
    Yi Li
    Department of Clinical Laboratory Medicine, Sixth Affiliate Hospital of Shanghai Jiao Tong University, 600 Yi Shan Rd, Shanghai 200233, People s Republic of China
    J Clin Microbiol 46:1317-21. 2008
    ..pneumoniae was the most prevalent bacterium harboring a PABL. To the best of our knowledge, this is the first report of CMY-2-type AmpC beta-lactamases in the Chinese mainland...
  81. ncbi Detection of Enterobacteriaceae producing CTX-M extended spectrum beta-lactamases from a tertiary care hospital in south India
    S Baby Padmini
    School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore 632 014, Tamil Nadu, India
    Indian J Med Microbiol 26:163-6. 2008
    ..Further sequencing resulted in identification of CTX-M-15 ESBLs. This is the first report identifying CTX-M type ESBL from clinical isolates of E. coli and K. pneumoniae from a tertiary care hospital in south India...
  82. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    ..coli isolates emerged in ICUs in our hospital. KPC-2 combined with porin deficiency results in high-level carbapenem resistance in K. pneumoniae. The same bla(KPC-2)-encoding plasmid was spread among the three different genera...
  83. ncbi Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss
    Dolunay Gulmez
    Hacettepe University Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 06100 Sihhiye, Ankara, Turkey
    Int J Antimicrob Agents 31:523-6. 2008
    ..Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted...
  84. pmc Detection of the Klebsiella pneumoniae carbapenemase type 2 Carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K. oxytoca carrying a common plasmid
    J Kamile Rasheed
    Division of Healthcare Quality Promotion, National Center for the Prevention, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 46:2066-9. 2008
    ..Restriction analysis and hybridization with a KPC-specific probe showed the bla(KPC-2) genes of these two genera of the family Enterobacteriaceae are carried on a common plasmid...
  85. ncbi Prevalence of extended-spectrum beta-lactamases among Escherichia coli and Klebsiella pneumoniae isolates in a tertiary care hospital
    Parul Agrawal
    Department of Microbiology, Armed Forces Medical College, Pune, India
    Indian J Pathol Microbiol 51:139-42. 2008
    ..Thus the prevalence of ESBL-producing isolates of E. coli and K. pneumoniae was found to be 22% (80 out of 357). This was significantly lower than the data available from other hospitals...
  86. ncbi Appearance of aac(6')-Ib-cr gene among extended-spectrum beta-lactamase-producing Enterobacteriaceae in a French hospital
    V Fihman
    Service de Bacteriologie Virologie, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite Paris VII, 2, rue Ambroise Pare, 75475 Paris, France
    J Infect 56:454-9. 2008
    ..The aim of our study was to observe the appearance and the location of the aac(6')-Ib gene in extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae strains...
  87. ncbi Characterization of TEM-, SHV- and AmpC-type beta-lactamases from cephalosporin-resistant Enterobacteriaceae isolated from swine
    Nabin Rayamajhi
    Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute, Brain Korea 21 for Veterinary Science, Seoul National University, San 56 1, Shilim 9 dong, Kwanak Ku, Seoul, Republic of Korea
    Int J Food Microbiol 124:183-7. 2008
    ..To the best of our knowledge, this study reports the first identification of SHV-28 and DHA-1 from microbes of animal origin...
  88. pmc Outbreaks in distinct regions due to a single Klebsiella pneumoniae clone carrying a bla VIM-1 metallo-{beta}-lactamase gene
    Alexandros Ikonomidis
    Department of Medical Microbiology, Medical School, University Hospital of Thessaly, Mezourlo, 411 10 Larissa, Greece
    J Clin Microbiol 43:5344-7. 2005
    ..The clonal spread of VIM-1-producing K. pneumoniae strains in distinct regions where up to now bla(VIM-2) and bla(VIM-4) alleles were common is worrisome...
  89. pmc Carbapenem-resistant isolates of Klebsiella pneumoniae in China and detection of a conjugative plasmid (blaKPC-2 plus qnrB4) and a blaIMP-4 gene
    Rodrigo E Mendes
    Antimicrob Agents Chemother 52:798-9. 2008
  90. ncbi [Carbapenemase detection in Acinetobacter baumannii clones resistant to imipenem]
    Lucía Gallego
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Vizcaya, Spain
    Enferm Infecc Microbiol Clin 22:262-6. 2004
    ....
  91. pmc Identification of extended-spectrum, AmpC, and carbapenem- hydrolyzing beta-lactamases in Escherichia coli and Klebsiella pneumoniae by disk tests
    George A Jacoby
    Lahey Clinic, Burlington, MA 01895, USA
    J Clin Microbiol 44:1971-6. 2006
    ..A relatively simple scheme was devised for distinguishing beta-lactamase types in clinical isolates with or without intact outer membrane porins...
  92. pmc Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae
    Hyunjoo Pai
    Division of Infectious Diseases, College of Medicine, Hanyang University, Seoul 133 791, Korea
    Antimicrob Agents Chemother 51:366-8. 2007
    ..pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distribution of plasmids conferring resistance to extended-spectrum cephalosporins and quinolones in clinical isolates of K. pneumoniae is widespread...
  93. pmc Effects of phenotype and genotype on methods for detection of extended-spectrum-beta-lactamase-producing clinical isolates of Escherichia coli and Klebsiella pneumoniae in Norway
    Ståle Tofteland
    Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
    J Clin Microbiol 45:199-205. 2007
    ..coli strains. The relatively high proportion of ESBL-producing E. coli organisms with a low ceftazidime MIC in Norway emphasizes that cefpodoxime alone or both cefotaxime and ceftazidime should be used as substrates for ESBL detection...
  94. ncbi [Conjugative transfer frequency of resistance genes from ESBL-producing Enterobacteriaceae strains isolated from patients hospitalized in pediatric wards]
    Roman Franiczek
    Katedra i Zakład Mikrobiologii Akademii Medycznej we Wrocławiu
    Med Dosw Mikrobiol 58:41-51. 2006
    ..Genetic markers conferring resistance to aminoglycosides and cotrimoxazole were often co-transferred to recipient strain in conjugation process...
  95. ncbi Real-time TaqMan PCR for rapid detection and typing of genes encoding CTX-M extended-spectrum beta-lactamases
    Christopher I Birkett
    Health Protection Agency, Clinical Microbiology and Public Health Laboratory, Addenbrooke s Hospital, Cambridge, UK
    J Med Microbiol 56:52-5. 2007
    ..The new TaqMan assay detected and typed bla(CTX-M) genes in 21 of 28 ESBL-producing isolates...
  96. pmc Antibiotic coresistance in extended-spectrum-beta-lactamase-producing Enterobacteriaceae and in vitro activity of tigecycline
    María Isabel Morosini
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain
    Antimicrob Agents Chemother 50:2695-9. 2006
    ..However, this in vitro promise requires support from clinical studies...
  97. ncbi [Activity of fosfomycin against extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae]
    Marina de Cueto
    Servicio de Microbiologia, Hospital Universitario Virgen Macarena, Sevilla, Espana
    Enferm Infecc Microbiol Clin 24:613-6. 2006
    ..The options for oral treatment of uncomplicated UTI are limited because of the multiple drug resistance typical of ESBL-producing strains...
  98. ncbi Sensitivity and specificity of various beta-lactam antibiotics and phenotypical methods for detection of TEM, SHV and CTX-M extended-spectrum beta-lactamases
    B Bedenic
    Department of Microbiology, School of Medicine, University of Zagreb, Zagreb, Croatia
    J Chemother 19:127-39. 2007
    ..Since MIC determination is a very laborious and time consuming method, we would recommend the NCCLS combined disk test or IPDD test for detection of ESBLs in routine laboratories with 5 mm zone augmentation breakpoint...
  99. pmc Multidrug-resistant Acinetobacter baumannii, Russia
    Thierry Naas
    Emerg Infect Dis 13:669-71. 2007
  100. pmc Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital
    Azita Leavitt
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Antimicrob Agents Chemother 51:3026-9. 2007
    ..This rapid dissemination of KPC outside the United States is worrisome...
  101. ncbi Risk factors for infection by extended-spectrum beta-lactamase producing Klebsiella pneumoniae in a tertiary hospital in Salvador, Brazil
    Nanci Silva
    Medicine and Public Health School of Bahia, Salvador, BA, Brazil
    Braz J Infect Dis 10:191-3. 2006
    ..Nosocomial infection caused by extended-spectrum beta-lactamase producing Klebsiella pneumoniae (ESBL-Kp) have been frequently reported worldwide. We have no information on such problems in Bahia, Brazil...

Research Grants28

  1. Structure of Beta-lactam resistance regulators
    MARTIN SAFO; Fiscal Year: 2007
    ..Subsequently, the structures of the proteins will be determined using X-ray crystallography. [unreadable] [unreadable]..
  2. Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faecium
    Louis B Rice; Fiscal Year: 2013
    ..They will also enhance our understanding of cell wall synthesis mechanisms in Gram-positive cocci and reveal promising new targets for antibacterial therapy. ..
  3. Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    Henry F Chambers; Fiscal Year: 2013
    ..Recombinant GdpP also will be purified and analyzed by x-ray crystallography to identify its critical structural properties. Achieving these aims will increase knowledge of ?-lactam antibiotic effects and mechanisms of resistance. ..
  4. Discovery of Small Molecules that Restore Methicillin Sensitivity to MRSA
    JENNIFER CAMPBELL O apos NEILL; Fiscal Year: 2010
    ..S. than HIV/AIDS, and existing therapies are failing. We have uncovered evidence that beta lactam resistance in MRSA, which is mediated in part by the expression of a gene (mecA) encoding a resistant transpeptidase (..
  5. Cell-based HTS for Compounds that Block Virulence Factor Expression in MRSA
    Suzanne Walker; Fiscal Year: 2009
    ..S. than HIV/AIDS, and existing therapies are failing. We have uncovered evidence that beta lactam resistance in MRSA, which is mediated in part by the expression of a gene (mecA) encoding a resistant transpeptidase (..
  6. Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    Binh An Diep; Fiscal Year: 2012
    ..The overall goal of the proposed research is to define the molecular basis for mecA-independent resistance to ?-lactams, which could lead to a better understanding of ?-lactam antibiotic effects and identification of novel drug targets. ..
  7. H. INFLUENZAE: PENICILLIN BINDING PROTEINS & CELL WALL
    Paul Mendelman; Fiscal Year: 1991
    ....
  8. PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 2003
    ..To augment information about where PBPs localize, when they are expressed during the cell cycle will be determined by Northern blotting. ..
  9. Oxacillinase and Bacterial beta-Lactam Resistance
    James Knox; Fiscal Year: 2003
    ..OXA-1 crystals which diffract to very high resolution (1.5 A) have been examined. ..
  10. Antibiotic Resistance in the Oral Streptococci
    Jeffrey Rogers; Fiscal Year: 2003
    ..pneumoniae, thus linking genetic exchange, the genesis of antibiotic resistance genes, and the role of the oral streptococci as a reservoir of antibiotic resistance determinants. ..
  11. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  12. PSEUDOMONAS AERUGINOSA FLAGELLAR BIOGENESIS PATHWAY
    Reuben Ramphal; Fiscal Year: 2007
    ..abstract_text> ..
  13. Dual Purpose b-Lactamase Inhibitors
    JOHN BUYNAK; Fiscal Year: 2004
    ..A group of scientists, including chemists, microbiologists, enzymologists, and crystallographers has been assembled to allow rapid optimization of SAR. ..
  14. Type II secretion system of P. aeruginosa in acute lung infection
    Reuben Ramphal; Fiscal Year: 2010
    ..We wish to examine which of the many known toxins are involved in death and to explore new methods to block secretion of the toxins that may eventually be useful for therapy. ..
  15. Recurrent otitis media and COPD: immunity and vaccines
    Timothy Murphy; Fiscal Year: 2004
    ..The proposed studies will advance the field of vaccine development to prevent otitis media and respiratory tract infections in COPD. ..
  16. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  17. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  18. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. New Nosocomial Interventions to Decrease Antimicrobial Resistance Transmission
    Anthony Harris; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. Enterococcus faecium virulence: A molecular and therapeutic approach
    Cesar Arias; Fiscal Year: 2008
    ..A translational approach using the mentor's laboratory established animal models (mouse peritonitis and rat infective endocarditis) will be utilized to explore therapeutic approaches. [unreadable] [unreadable] [unreadable]..
  22. Study of Mechanisms Leading to Multidrug-Resistant K. pneumoniae and A. baumannii
    John Quale; Fiscal Year: 2008
    ..The clinical and economic consequences of nosocomial infections due to multidrug-resistant bacteria are staggering. [unreadable] [unreadable] [unreadable]..
  23. FLAGELLIN GLYCOSYLATION AND VIRULENCE OF P. AEROGINOSA
    Reuben Ramphal; Fiscal Year: 2005
    ..The existence of a central gene product involved in these could prove to be of great significance in controlling virulence. ..
  24. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
  25. DEVELOPMENT OF A VACCINE FOR MORAXELLA CATARRHALIS
    Timothy Murphy; Fiscal Year: 2009
    ..catarrhalis surface, the identification of surface antigens expressed specifically during human infection and critical information about the human immune response to surface antigens of M. catarrhalis. ..