- Genetic tools for select-agent-compliant manipulation of Burkholderia pseudomallei
Kyoung Hee Choi
Department of Microbiology, Immunology and Pathology, Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University, Fort Collins, CO 80523 1682, USA
Appl Environ Microbiol 74:1064-75. 2008
..The new tools allow routine select-agent-compliant genetic manipulations of B. pseudomallei and other Burkholderia species...
- Antimicrobial resistance: it's not just for hospitals
Elizabeth A Bancroft
JAMA 298:1803-4. 2007
- Bacteroides: the good, the bad, and the nitty-gritty
Hannah M Wexler
Wadsworth Anaerobe Laboratory, Greater Los Angeles VA Healthcare Systems University of California, Los Angeles, CA 90073, USA
Clin Microbiol Rev 20:593-621. 2007
..Clinically, Bacteroides species have exhibited increasing resistance to many antibiotics, including cefoxitin, clindamycin, metronidazole, carbapenems, and fluoroquinolones (e.g., gatifloxacin, levofloxacin, and moxifloxacin)...
- Mechanisms of resistance to quinolones
George A Jacoby
Lahey Clinic, Burlington, Massachusetts 01805, USA
Clin Infect Dis 41:S120-6. 2005
..Although Qnr by itself produces only low-level resistance, its presence facilitates the selection of higher-level resistance mutations, thus contributing to the alarming increase in resistance to quinolones...
- Outpatient antibiotic use in Europe and association with resistance: a cross-national database study
ESAC Management Team, Department of Microbiology, University of Antwerp, B 2610 Antwerp, Belgium
Lancet 365:579-87. 2005
..Our aim was to assess outpatient use of antibiotics and the association with resistance...
- Typhoid fever
Christopher M Parry
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
N Engl J Med 347:1770-82. 2002
- Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes
Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
Antimicrob Agents Chemother 48:1-14. 2004
- Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials
A L Spoering
Department of Biology, Northeastern University, 405 Mugar, 360 Huntington Ave, Boston, MS 02115, USA
J Bacteriol 183:6746-51. 2001
..We further suggest that tolerance to antibiotics in stationary-phase or biofilm cultures is largely dependent on the presence of persister cells...
- The worldwide emergence of plasmid-mediated quinolone resistance
Massachusetts General Hospital, Boston, MA 02114 2696, USA
Lancet Infect Dis 6:629-40. 2006
- Non-inherited antibiotic resistance
Bruce R Levin
Department of Biology, Emory University, Atlanta, Georgia 30307, USA
Nat Rev Microbiol 4:556-62. 2006
- Bacterial persistence as a phenotypic switch
Nathalie Q Balaban
Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 305:1622-5. 2004
..Inherent heterogeneity of bacterial populations may be important in adaptation to fluctuating environments and in the persistence of bacterial infections...
- A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
Vivian G Loo
Department of Microbiology, McGill University Health Center, Montreal, Que, Canada
N Engl J Med 353:2442-9. 2005
..In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea...
- Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Zentrum fur Innere Medizin, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Gut 56:772-81. 2007
..Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000...
- The antibiotic resistome: the nexus of chemical and genetic diversity
Gerard D Wright
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main Street West Hamilton, Ontario, L8N 3Z5, Canada
Nat Rev Microbiol 5:175-86. 2007
..Why is resistance inevitable and where does it come from? Understanding the molecular diversity that underlies resistance will inform our use of these drugs and guide efforts to develop new efficacious antibiotics...
- Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?
David M Livermore
Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London, United Kingdom
Clin Infect Dis 34:634-40. 2002
..A few isolates of P. aeruginosa are resistant to all reliable antibiotics, and this problem seems likely to grow with the emergence of integrins that carry gene cassettes encoding both carbapenemases and amikacin acetyltransferases...
- Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments
Katie L Hopkins
Antimicrobial Resistance and Molecular Epidemiology Unit, Laboratory of Enteric Pathogens, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5HT, UK
Int J Antimicrob Agents 25:358-73. 2005
- Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance
Helen L Leavis
Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Curr Opin Microbiol 9:454-60. 2006
..This complex is correlated with ampicillin and quinolone resistance and with the presence of a putative pathogenicity island. Preliminary MLST data suggest that similar hospital-adapted complexes might also exist in E. faecalis...
- Resistance in gram-negative bacteria: enterobacteriaceae
David L Paterson
Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Med 119:S20-8; discussion S62-70. 2006
..Better antibiotic stewardship and infection control are needed to prevent further spread of ESBLs and other forms of resistance in Enterobacteriaceae throughout the world...
- Bistability in bacteria
Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
Mol Microbiol 61:564-72. 2006
..A review describing additional examples of bistability in bacteria has been published recently...
- Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection
Department of Microbiology, Institut Clinic Infeccions i Immunologia, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
J Antimicrob Chemother 51:1109-17. 2003
..Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones...
- Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance
Matthew T G Holden
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
Proc Natl Acad Sci U S A 101:9786-91. 2004
- Bacteria subsisting on antibiotics
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Science 320:100-3. 2008
..This phenomenon suggests that this unappreciated reservoir of antibiotic-resistance determinants can contribute to the increasing levels of multiple antibiotic resistance in pathogenic bacteria...
- Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil
Rosilene Fressatti Cardoso
Department of Clincal Analysis, State University of Maringa, Parana, Brazil
Antimicrob Agents Chemother 48:3373-81. 2004
..Since ca. 90.7% of the INH-resistant isolates had mutations identified by SSCP electrophoresis, this method may be a useful genotypic screen for INH resistance...
- New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate
Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
Antimicrob Agents Chemother 51:3354-60. 2007
..coli was first identified. Surveillance of the qepA-harboring clinical isolates should be encouraged to minimize further dissemination of the kind of plasmid-dependent FQ resistance determinants among pathogenic microbes...
- Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations
Department of Biology, Emory University, 1510 Clifton Rd, Atlanta, Georgia 30322, USA
Antimicrob Agents Chemother 49:1483-94. 2005
- Inhibition of mutation and combating the evolution of antibiotic resistance
Ryan T Cirz
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA
PLoS Biol 3:e176. 2005
..Our findings indicate that the inhibition of mutation could serve as a novel therapeutic strategy to combat the evolution of antibiotic resistance...
- Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals
Carl T Bergstrom
Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
Proc Natl Acad Sci U S A 101:13285-90. 2004
..As a consequence, cycling is unlikely to be effective and may even hinder resistance control. These results may explain the limited success reported thus far from clinical trials of antimicrobial cycling...
- An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
David E Griffith
Am J Respir Crit Care Med 175:367-416. 2007
- Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome
Cheol In Kang
Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 744, Republic of Korea
Antimicrob Agents Chemother 49:760-6. 2005
..72; P = 0.030). Our data suggest that inappropriate initial antimicrobial therapy is associated with adverse outcome in antibiotic-resistant gram-negative bacteremia, particularly in patients with a high-risk source of bacteremia...
- Tuberculosis due to resistant Haarlem strain, Tunisia
Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
Emerg Infect Dis 11:957-61. 2005
..A detailed investigation showed accelerated transmission of a Mycobacterium tuberculosis clone of the Haarlem type in 90% of all patients. This finding highlights the epidemic potential of this prevalent genotype...
- Antimicrobial resistance of Escherichia coli O157 isolated from humans, cattle, swine, and food
Carl M Schroeder
Department of Nutrition and Food Science, 3304 Marie Mount Hall, University of Maryland, College Park, MD 20742, USA
Appl Environ Microbiol 68:576-81. 2002
- Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis
Srinivas V Ramaswamy
Houston Tuberculosis Initiative, Department of Pathology, Baylor College of Medicine, University of Texas Medical School, Houston, Texas 77030, USA
Antimicrob Agents Chemother 47:1241-50. 2003
..These genes either are involved in mycolic acid biosynthesis or are overexpressed as a response to the buildup or cellular toxicity of INH...
- Origin of plasmid-mediated quinolone resistance determinant QnrA
Service de Bacteriologie Virologie, Hopital de Bicetre, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
Antimicrob Agents Chemother 49:3523-5. 2005
..Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene...
- Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones
Patrick F McDermott
Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA
J Infect Dis 185:837-40. 2002
- Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
Chi Hye Park
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
Antimicrob Agents Chemother 50:3953-5. 2006
..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
- Antimicrobial drug use and resistance in Europe
Nienke van de Sande-Bruinsma
National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Emerg Infect Dis 14:1722-30. 2008
..Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe...
- Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK
Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London
J Antimicrob Chemother 54:735-43. 2004
..e. MICs of cefotaxime > or = 8-fold higher than MICs of ceftazidime. Many were referred as being from community patients. We examined 291 CTX-M-producing isolates from the UK and investigated the genetic basis of their phenotype...
- How do bacteria resist human antimicrobial peptides?
Microbial Genetics, University of Tubingen, Auf der Morgenstelle 28, 72076, Tubingen, Germany
Trends Microbiol 10:179-86. 2002
..Mutants susceptible to CAMPs are more efficiently inactivated by phagocytes and are virulence-attenuated, indicating that CAMP resistance plays a key role in bacterial infections...
- The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Central Asia
Helen Suzanne Cox
Medecins Sans Frontieres, Aral Sea Area Programme, Uzbekistan and Turkmenistan Tashkent, Uzbekistan
Respir Res 6:134. 2005
..However, recent studies have raised concern that the Beijing genotype of Mycobacterium tuberculosis might be contributing to the epidemic through its widespread presence and potentially enhanced ability to acquire resistance...
- Decrease of invasive pneumococcal infections in children among 8 children's hospitals in the United States after the introduction of the 7-valent pneumococcal conjugate vaccine
Sheldon L Kaplan
Pediatric Infectious Diseases Sections of the Baylor College of Medicine, Houston, Texas, USA
Pediatrics 113:443-9. 2004
- Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement
Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK
Lancet Infect Dis 8:133-9. 2008
..An important strategy to promote drug discovery will be the development of focused cooperations between academic institutions and small pharmaceutical companies...
- HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins
Program in Bioinformatics and Systems Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Trends Biochem Sci 28:224-6. 2003
..The distant structural similarity suggests that this domain might be involved in nucleotide binding...
- Development of a miniaturised microarray-based assay for the rapid identification of antimicrobial resistance genes in Gram-negative bacteria
Department of Food and Environmental Safety, Veterinary Laboratories Agency, Addlestone, Surrey, UK
Int J Antimicrob Agents 31:440-51. 2008
- Sustainability for behaviour change in the fight against antibiotic resistance: a social marketing framework
Department of Communication Sciences and Disorders, Emerson College, 120 Boylston Street, Boston, MA 02116, USA
J Antimicrob Chemother 63:230-7. 2009
..This paper provides an overview of previous communication-based initiatives and offers a detailed approach to social marketing to guide future efforts...
- Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications
Service de Microbiologie, Hôpital Côte de Nacre, Universite de Caen, Caen 14033, France
Clin Infect Dis 34:482-92. 2002
..These results support the need for in vitro detection of macrolide resistance and correct interpretation of susceptibility tests to guide therapy...
- A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase
Marcus J Edwards
Department of Biological Chemistry, John Innes Centre, Colney, Norwich NR4 7UH, UK
Science 326:1415-8. 2009
..Our results should facilitate the design of drug molecules that target these unexploited binding pockets...
- Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae
Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris Sud, 78 rue du General Leclerc, 94275, K Bicêtre, France
J Antimicrob Chemother 56:463-9. 2005
..Further analysis of the role (if any) of quinolones for enhancing this gene transfer may be conducted. This could prevent the spread, if still possible, of this novel antibiotic resistance mechanism...
- Susceptibility of Lactobacillus spp. to antimicrobial agents
Identification Section, Applied Biotechnology, Chr Hansen A S, Bøge Allé 10 12, 2970 Hørsholm, Denmark
Int J Food Microbiol 82:1-11. 2003
..On the basis of the result, it was possible to suggest minimal inhibition concentrations (MICs) for the individual Lactobacillus species to be used as a microbiological breakpoint when screening strains for transferable resistance genes...
- Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints
Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
PLoS ONE 4:e7407. 2009
..According to the standard view, isolates exhibiting the same fingerprinting pattern are considered direct progeny of the same bacterial clone, and most likely reflect ongoing transmission or disease relapse within individual patients...
- Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Cell 121:257-70. 2005
..coli) that stacks between them. The structure of large subunit containing a three residue deletion mutant of L22 shows a change in the L22 structure and exit tunnel shape that illuminates its macrolide resistance phenotype...
- 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Infect Dis 45:88-94. 2007
..A 2-tiered approach, consisting of disk diffusion tests followed by confirmation with polymerase chain reaction, is recommended for detection of 16S rRNA methylase-mediated resistance...
- Transfer of antibiotic resistance between commensal and pathogenic members of the Enterobacteriaceae under ileal conditions
D P Blake
Centre for Microbiological Research, Veterinary Science Division, SAC, Craibstone, Aberdeen, AB21 9YA, UK
J Appl Microbiol 95:428-36. 2003
..To determine the rate of antibiotic resistance transmission between commensal and pathogenic representatives of the Enterobacteriaceae...
- Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain
Annie Claude Labbe
Department of Microbiology, Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
Antimicrob Agents Chemother 52:3180-7. 2008
..Stringent antibiotic stewardship measures, combined with aggressive infection control, are required to curtail the epidemic of C. difficile infections...
- Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia
Ki Tae Kwon
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Seoul 135 710, Korea
J Antimicrob Chemother 59:525-30. 2007
..To investigate the impact of imipenem resistance on the mortality rate among patients with Acinetobacter bacteraemia...
- Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment
Deborah J Griggs
Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom
Antimicrob Agents Chemother 49:699-707. 2005
..Most ciprofloxacin-resistant isolates had the GyrA substitution Thr-86-->Ile. Resistant isolates were isolated from the feces of some flocks up to the point of slaughter, which may have consequences for public health...
- Persister cells and the riddle of biofilm survival
Northeastern University, Boston, MA 02115, USA
Biochemistry (Mosc) 70:267-74. 2005
..Persisters are essentially altruistic cells that forfeit propagation in order to ensure survival of kin cells in the presence of lethal factors...
- The genetic background for streptomycin resistance in Escherichia coli influences the distribution of MICs
Section of Bacteriology and Norwegian Zoonosis Centre, National Veterinary Institute, Oslo
J Antimicrob Chemother 56:87-90. 2005
..The aim of this study was to investigate the genetic background for streptomycin resistance in Escherichia coli and perform analysis of the MICs in relation to genetic background...
- Analysis of antimicrobial susceptibility and virulence factors in Helicobacter pylori clinical isolates
Anita Paula Ortiz Godoy
Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Braganca Paulista, SP, Brazil
BMC Gastroenterol 3:20. 2003
..In addition, the vacA, iceA, cagA and cagE genotypes of strains isolated from Brazilian patients were determined and associated with clinical data in an effort to correlate these four virulence markers and antibiotic resistance...
- Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections
Patricia Komp Lindgren
Department of Cell and Molecular Biology, Microbiology Programme, Biomedical Center, Uppsala University, S 751 24 Uppsala, Sweden
Antimicrob Agents Chemother 47:3222-32. 2003
..This correlation suggests that an increased general mutation rate may play a significant role in the development of high-level resistance to fluoroquinolones by increasing the rate of accumulation of rare new mutations...
- Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica
Deborah J Eaves
Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
Antimicrob Agents Chemother 48:4012-5. 2004
..Although it is counterintuitive, isolates with a mutation in both gyrA and parC were more susceptible to ciprofloxacin than were isolates with a mutation in gyrA alone...
- Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis
Francisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
J Clin Microbiol 44:595-7. 2006
..The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses...
- Antibiotics: a shot in the arm
Nature 431:892-3. 2004
- Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada
David A Boyd
Nosocomial Infections, National Microbiology Laboratory, 1015 Arlington St, Winnipeg, Manitoba, Canada
Antimicrob Agents Chemother 48:3758-64. 2004
..coli strain isolated in India in 1999, revealed that the plasmids had several features in common, including an R100 backbone and several of the resistance genes, including bla(CTX-M-15), bla(TEM-1), bla(OXA-1), tetA, and aac(6')-Ib...
- Molecular mechanisms of bacterial resistance to antimicrobial peptides
Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Institute, University of Tubingen, Germany
Curr Top Microbiol Immunol 306:231-50. 2006
..CAMPs or conserved CAMP resistance factors are discussed as new mediators and targets, respectively, of novel and sustainable anti-infective strategies...
- Antimicrobial susceptibility trends among Escherichia coli and Shigella spp. isolated from rural Egyptian paediatric populations with diarrhoea between 1995 and 2000
S D Putnam
Enteric Disease Department, Naval Medical Research Center, Silver Spring, MD, USA
Clin Microbiol Infect 10:804-10. 2004
..Overall, high levels, but decreasing trends, of resistance to commonly used antimicrobial agents were detected among isolates of E. coli and Shigella spp. from children in rural Egypt...
- Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates from England and Wales reveals the phylogenetic significance of the ahpC -46A polymorphism
L V Baker
HPA Mycobacterium Reference Unit, Department of Microbiology, Guy s, King s and St Thomas School of Medicine, King s College Hospital, East Dulwich Grove, London SE22 8QF, United Kingdom
Antimicrob Agents Chemother 49:1455-64. 2005
..Analysis of the oxyR-ahpC intergenic region, although phylogenetically interesting, does not contribute significantly to further identification of isoniazid-resistant isolates...
- Common regions e.g. orf513 and antibiotic resistance: IS91-like elements evolving complex class 1 integrons
Mark A Toleman
Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk Bristol BS8 1TD, UK
J Antimicrob Chemother 58:1-6. 2006
..In this article, we provide a brief description of these new and clinically important mobile elements, and how they are able to mobilize antibiotic resistance genes...
- Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan
Department of Urology, Gifu University School of Medicine, 1 1 Yanagido, Gifu City 501 1194, Japan
Antimicrob Agents Chemother 49:137-43. 2005
..The emergence of such strains may be the result of the in vivo generation of clones in which interspecies recombination occurred between the penA genes of N. gonorrhoeae and commensal Neisseria species...
- Mechanisms of bacterial resistance to chromium compounds
Martha I Ramírez-Díaz
Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Edificio B 3, Ciudad Universitaria, Morelia, Michoacan 58030, Mexico
Biometals 21:321-32. 2008
..Other mechanisms of bacterial resistance to chromate involve the expression of components of the machinery for repair of DNA damage, and systems related to the homeostasis of iron and sulfur...
- Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin
Jeffrey B Locke
Trius Therapeutics, Inc, San Diego, CA 92121, USA
Antimicrob Agents Chemother 53:5275-8. 2009
..The oxazolidinone torezolid maintained a >or=8-fold potency advantage over linezolid for both strains...
- Modelling protection from antimicrobial agents in biofilms through the formation of persister cells
Mark E Roberts
Center for Biofilm Engineering and Department of Chemical and Biological Engineering, Montana State University Bozeman, Bozeman, MT 59717 3980, USA
Microbiology 151:75-80. 2005
..This modelling study provides motivation for further investigation of the hypothetical persister cell state as an explanation for biofilm resistance to antimicrobial agents...
- Diversity of arsenite transporter genes from arsenic-resistant soil bacteria
Asma Rokbani Achour
Laboratoire Ecotoxicité et Santé Environnementale ESE, UMR7146, CNRS, Universite Paul Verlaine, Campus Bridoux, rue du General Delestraint, 57070 Metz, France
Res Microbiol 158:128-37. 2007
- Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years
Infectious Diseases Section, Carney Hospital, 2100 Dorchester Avenue, Boston, MA 02124, USA
Infect Control Hosp Epidemiol 24:699-706. 2003
- Antibiotics in animal feed and their role in resistance development
Henrik C Wegener
Danish Zoonosis Centre, Danish Veterinary Institute, Bulowsvej 27, DK 1790 V, Copenhagen, Denmark
Curr Opin Microbiol 6:439-45. 2003
..The data shows that although the levels of resistance in animals and food, and consequently in humans, has been markedly reduced after the termination of use, the effects on animal health and productivity have been very minor...
- Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America
Elis R Dalla Costa
State Foundation for Production and Research in Health FEPPS, Porto Alegre, Brazil
BMC Microbiol 9:39. 2009
- Isolation and characterization of arsenate-reducing bacteria from arsenic-contaminated sites in New Zealand
Craig R Anderson
Department of Microbiology, Otago School of Medical Sciences, University of Otago, P O Box 56, Dunedin, New Zealand
Curr Microbiol 48:341-7. 2004
..As a subsidiary process to arsenate reduction, the external pH of the growth medium increased (i.e., became more alkaline), allowing these bacteria to grow for extended periods of time...
- Bacterial adaptation and resistance to antiseptics, disinfectants and preservatives is not a new phenomenon
A D Russell
Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, UK
J Hosp Infect 57:97-104. 2004
- Relapse and acquired rifampin resistance in HIV-infected patients with tuberculosis treated with rifampin- or rifabutin-based regimens in New York City, 1997-2000
Bureau of Tuberculosis Control, New York City Department of Health and Mental Hygiene, New York, NY 10007, USA
Clin Infect Dis 41:83-91. 2005
..The relationship between rifamycin use and either relapse or treatment failure with acquired rifampin resistance (ARR) among human immunodeficiency virus (HIV)-infected patients with tuberculosis (TB) is not well understood...
- Campylobacter susceptibility to ciprofloxacin and corresponding fluoroquinolone concentrations within the gastrointestinal tracts of chickens
M B Farnell
Poultry Production and Product Safety Research Unit, Agricultural Research Service, USDA, Fayetteville, AR 72701, USA
J Appl Microbiol 99:1043-50. 2005
..This study evaluated the relationship between Campylobacter susceptibility and enteric fluoroquinolone concentrations in chickens treated with different doses of enrofloxacin...
- The neglected intrinsic resistome of bacterial pathogens
Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas CSIC, Cantoblanco, Madrid, Spain
PLoS ONE 3:e1619. 2008
..Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature...
- The bacteria fight back
Science 321:356-61. 2008
- CTX-M beta-lactamases in Escherichia coli from community-acquired urinary tract infections, Cambodia
Institut Pasteur du Cambodge, Phnom Penh, Cambodia
Emerg Infect Dis 15:741-8. 2009
..The prevalence of CTX-M beta-lactamases has reached a critical level in Cambodia, which highlights the need for study of their spread in developing countries...
- Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp
Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5HT, UK
Int J Antimicrob Agents 27:351-3. 2006
..Genes encoding OXA-58 were detected (with bla(OXA-51-like)) in a cluster of related isolates from a single hospital. This simple assay will assist in monitoring the mechanisms responsible for carbapenem resistance in Acinetobacter spp...
- Isolation and molecular characterization of nalidixic acid-resistant extraintestinal pathogenic Escherichia coli from retail chicken products
James R Johnson
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
Antimicrob Agents Chemother 47:2161-8. 2003
- Rapid dissemination and diversity of CTX-M extended-spectrum beta-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America
Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Universita di Siena, Policlinico Santa Maria alle Scotte, Siena, Italy
Antimicrob Agents Chemother 51:2720-5. 2007
..Three CTX-M-15-encoding conjugative plasmids from Peruvian isolates carried the new fluoroquinolone resistance gene aac(6')-Ib-cr. To our best knowledge, this is the first report of the detection of aac(6')-Ib-cr in Latin America...
- Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006
George G Zhanel
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Antimicrob Agents Chemother 52:1430-7. 2008
..aeruginosa, H. influenzae, Enterococcus spp., S. pneumoniae, and K. pneumoniae are the most common isolates recovered from clinical specimens in Canadian ICUs. A MDR phenotype is common for P. aeruginosa isolates in Canadian ICUs...
- Antimicrobial susceptibility and synergy studies of Stenotrophomonas maltophilia isolates from patients with cystic fibrosis
Pablo San Gabriel
Department of Pediatrics, Columbia University, New York, New York 10032, USA
Antimicrob Agents Chemother 48:168-71. 2004
..To determine appropriate treatment for patients with CF, it is important to monitor the prevalence, antimicrobial susceptibility, and clinical impact of S. maltophilia in this patient population...
- A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae
Kevin A Nash
Department of Pathology and Laboratory Medicine, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
Antimicrob Agents Chemother 53:1367-76. 2009
..The inducible macrolide resistance phenotype of some M. abscessus isolates may explain the lack of efficacy of macrolide-based chemotherapy against this organism...
- Antibiotic resistance in the absence of antimicrobial use: mechanisms and implications
Universita di Siena, Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Policlinico Santa Maria alle Scotte, Siena, Italy
Expert Rev Anti Infect Ther 6:725-32. 2008
- Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality
Mitchell J Schwaber
Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
Antimicrob Agents Chemother 52:1028-33. 2008
..6; and P = 0.03; for the CRKP group versus the controls, OR, 5.0; 95% CI, 1.7 to 14.8; and P = 0.004). CRKP affects patients with poor functional status, an ICU stay, and antibiotic exposure and is an independent predictor of death...
- Antibiotic resistance--the interplay between antibiotic use in animals and human beings
Randall S Singer
College of Veterinary Medicine, University of Illinois, IL, USA
Lancet Infect Dis 3:47-51. 2003
- Recurrent isolation of hydrogen peroxide-resistant spores of Bacillus pumilus from a spacecraft assembly facility
Michael J Kempf
Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109, USA
Astrobiology 5:391-405. 2005
..pumilus in a clean-room is a concern because their persistence might potentially compromise life-detection missions, which have very strict cleanliness and sterility requirements for spacecraft hardware...
- High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium
Helen L Leavis
Department of Internal Medicine, Division of Infectious Diseases and Internal Medicine, Eijkman Winkler Institute, University Medical Center Utrecht, Heidelberglaan 100, Rm G04 614, 3584CX Utrecht, The Netherlands
J Clin Microbiol 44:1059-64. 2006
..Acquisition of mutations in parC and gyrA, leading to high-level Cip(r), is, in addition to ampicillin resistance and the presence of a putative pathogenicity island, another cumulative step in hospital adaptation of CC17...
- A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA
Subray S Hegde
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Science 308:1480-3. 2005
..This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo...
- Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment
Felipe C Cabello
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Environ Microbiol 8:1137-44. 2006
- Efflux pumps as antimicrobial resistance mechanisms
Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada
Ann Med 39:162-76. 2007
- Safety assessment of dairy microorganisms: the Enterococcus genus
Jean Claude Ogier
Unité des Bactéries Lactiques et Pathogènes Opportunistes, INRA, Domaine de Vilvert, 78350 Jouy en Josas, France
Int J Food Microbiol 126:291-301. 2008
..According to food safety assessment guidelines, we propose a case-by-case evaluation of each potential technological strain and suggest several lines of research before using enterococci in fermented food products...
- Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever
Minh Duy Phan
The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
Antimicrob Agents Chemother 53:716-27. 2009
..We propose that antibiotic selection acts to maintain resistance genes on the plasmid, but there is also competition between plasmids encoding the same resistance phenotype...
- Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes
Marilyn C Roberts
Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
FEMS Microbiol Lett 282:147-59. 2008
..These mobile elements may play a role in the continued spread of the MLSKO resistance genes into new species, genera, and ecosystems...
- qnr Gene nomenclature
Lahey Clinic, Burlington, Massachusetts MA 01805, USA
Antimicrob Agents Chemother 52:2297-9. 2008
- The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada
Matthew T Blahna
Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, 48109, USA
J Antimicrob Chemother 57:666-72. 2006