- Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia
Department of Biology, Addis Ababa University, Addis Ababa, Ethiopia
Malar J 7:220. 2008
..Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country. The first report of CQ treatment failure in P. vivax was from Debre Zeit, which suggested the presence of chloroquine resistance...
- A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus
Sven D Willger
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT, USA
PLoS Pathog 4:e1000200. 2008
..Thus, these findings present a new function of SREBP proteins in filamentous fungi, and demonstrate for the first time that hypoxia adaptation is likely an important virulence attribute of pathogenic molds...
- Vivax malaria: neglected and not benign
Ric N Price
International Health Program, Menzies School of Health Research and Charles Darwin University, Casuarina, Darwin, Northern Territory 0811, Australia
Am J Trop Med Hyg 77:79-87. 2007
..Without these, vivax malaria will continue to be neglected by ministries of health, policy makers, researchers, and funding bodies...
- Chloroquine-resistant Plasmodium vivax, Brazilian Amazon
Franklin Simoes de Santana Filho
Emerg Infect Dis 13:1125-6. 2007
- The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Cai Hong Yun
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:2070-5. 2008
..kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug resistance conferred by a second mutation, T790M...
- Artemisinin resistance in Plasmodium falciparum malaria
Arjen M Dondorp
Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
N Engl J Med 361:455-67. 2009
..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance.
- Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
Aung Pyae Phyo
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 379:1960-6. 2012
..We aimed to establish whether artemisinin resistance has spread or emerged on the Thailand-Myanmar (Burma) border...
- A major genome region underlying artemisinin resistance in malaria
Ian H Cheeseman
Texas Biomedical Research Institute, San Antonio, TX 78245, USA
Science 336:79-82. 2012
- Drug resistance in leishmaniasis
Simon L Croft
Drugs for Neglected Diseases Initiative, 1 place Saint Gervais, CH 1201 Geneva, Switzerland
Clin Microbiol Rev 19:111-26. 2006
- Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, United Kingdom
Genome Res 21:2143-56. 2011
..sequence data reveals genetic structure within these lines not shown by multilocus typing, and suggests that drug resistance has emerged multiple times in this closely related set of lines...
- Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
John C Wootton
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 6075, USA
Nature 418:320-3. 2002
..The presence of linkage disequilibrium provides a basis for mapping genes under drug selection in P. falciparum...
- Artemisinin resistance: current status and scenarios for containment
Arjen M Dondorp
Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok10400, Thailand
Nat Rev Microbiol 8:272-80. 2010
..Mathematical modelling can be a useful tool to evaluate possible strategies for containment...
- Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
Verena Ilona Carrara
Shoklo Malaria Research Unit, Tak, Thailand
PLoS ONE 4:e4551. 2009
- A molecular marker for chloroquine-resistant falciparum malaria
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
N Engl J Med 344:257-63. 2001
..Chloroquine resistance has been associated in vitro with point mutations in two genes, pfcrt and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1, respectively...
- Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
James G Kublin
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Infect Dis 187:1870-5. 2003
..The reintroduction of chloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives remain unavailable...
- Spiroindolones, a potent compound class for the treatment of malaria
Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH 4002 Basel, Switzerland
Science 329:1175-80. 2010
..The optimized spiroindolone NITD609 shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model...
- Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite
Daniel J Park
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 109:13052-7. 2012
..and the combination of association and selection-based tests, we detected several loci associated with drug resistance. These loci included the previously known signals at pfcrt, dhfr, and pfmdr1, as well as many genes not ..
- Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia
Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
Clin Infect Dis 51:e82-9. 2010
..This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine...
- Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
M B Reed
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Nature 403:906-9. 2000
..This has important implications for the development and efficacy of future antimalarial agents...
- Drug resistance in veterinary helminths
Adrian J Wolstenholme
Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Trends Parasitol 20:469-76. 2004
..This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area...
- Intercontinental spread of pyrimethamine-resistant malaria
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Science 305:1124. 2004
..The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis...
- Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance
B P Koirala Institute of Health Sciences, Dharan, Nepal
Clin Infect Dis 56:1530-8. 2013
..Given the paucity of anti-VL drugs and the looming threat of resistance, there is an obvious need for close monitoring of clinical efficacy of MIL...
- Chloroquine resistance before and after its withdrawal in Kenya
Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
Malar J 8:106. 2009
..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared...
- Artemisinin combination therapy for vivax malaria
Nicholas M Douglas
Menzies School of Health Research, Darwin, NT, Australia
Lancet Infect Dis 10:405-16. 2010
..Analyses of the cost-effectiveness of ACTs for both Plasmodium species are needed to assess the role of these drugs in the control and elimination of vivax malaria...
- High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581
National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
PLoS ONE 4:e4569. 2009
..High levels of drug resistance to SP have been reported from north-eastern Tanzania associated with mutations in parasite genes...
- The role of ABC transporters in drug resistance, metabolism and toxicity
SOLVO Biotechnology, Szeged, Hungary
Curr Drug Deliv 1:27-42. 2004
..deal with the human ABC transporters as targets of therapeutic interventions in medicine, including cancer drug resistance, lipid and other metabolic disorders, and even gene therapy applications...
- In vivo parasitological measures of artemisinin susceptibility
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
J Infect Dis 201:570-9. 2010
- Identification of the gene for vitamin K epoxide reductase
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Nature 427:541-4. 2004
..The expressed enzyme is 163 amino acids long, with at least one transmembrane domain. Identification of the VKOR gene extends our understanding of blood clotting, and should facilitate development of new anticoagulant drugs...
- Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawal
Service de Parasitologie Mycologie, Faculte de Medecine, Universite Cheikh Anta Diop, Dakar, Senegal
Am J Trop Med Hyg 87:640-5. 2012
As a result of widespread antimalarial drug resistance, all African countries with endemic malaria have, in recent years, changed their malaria treatment policy...
- Detection of high levels of mutations involved in anti-malarial drug resistance in Plasmodium falciparum and Plasmodium vivax at a rural hospital in southern Ethiopia
National Centre for Tropical Medicine, Institute of Health Carlos III, C Sinesio Delgado 4 6, 28029, Madrid, Spain
Malar J 10:214. 2011
In Ethiopia, malaria is caused by Plasmodium falciparum and Plasmodium vivax, and anti-malarial drug resistance is the most pressing problem confronting control of the disease...
- Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations
Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, Japan
J Infect Dis 204:1980-8. 2011
..It remains unresolved whether P. falciparum resistance to sulfadoxine, which is conferred by mutations in dihydropteroate synthase (DHPS), evolved following a similar pattern...
- Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance
The Fred Wyszkowski Cancer Research Laboratory, Faculty of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
Drug Resist Updat 15:183-210. 2012
..g. BGC 945). Hence, targeting mechanisms of antifolate-resistance could facilitate the development of rationally-based novel antifolates and strategies that overcome chemoresistance...
- Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance
Maria Isabel Veiga
Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e20212. 2011
..Southeast Asia is an epicenter of emerging antimalarial drug resistance, including recent resistance to the artemisinins, the core component of all recommended antimalarial ..
- Molecular analysis of pfatp6 and pfmdr1 polymorphisms and their association with in vitro sensitivity in Plasmodium falciparum isolates from the Thai-Myanmar border
Thailand Center of Excellence on Drug Discovery and Development, Thammasat University, Rangsit Campus, Patumthani 12121, Thailand
Acta Trop 120:130-5. 2011
..No association between mutation or amplification of pfatp6 gene and in vitro susceptibility of P. falciparum isolates was found...
- Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance
Whitney E Harrington
Malaria Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
Clin Infect Dis 53:224-30. 2011
..However, parasites resistant to SP are widespread in parts of Africa, and IPTp may perversely exacerbate placental infections that contain SP-resistant parasites...
- Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Science 333:724-9. 2011
Malaria remains a devastating disease largely because of widespread drug resistance. New drugs and a better understanding of the mechanisms of drug action and resistance are essential for fulfilling the promise of eradicating malaria...
- In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
J Infect Dis 199:750-7. 2009
..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
- The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy
Andrew F Read
Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 108:10871-7. 2011
..An evidence-based approach to resistance management is required...
- In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
J Infect Dis 191:1014-7. 2005
..derivative-based combination therapy is expected to suppress the development of Plasmodium falciparum drug resistance in Africa...
- Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus
Mike Y Osei-Atweneboana
Institute of Parasitology, McGill University, Montreal, Canada
PLoS Negl Trop Dis 5:e998. 2011
..In this follow up study we have investigated the reproductive response of female worms to multiple treatments with IVM...
- Spread and evolution of Plasmodium falciparum drug resistance
Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, School of Medicine, 9 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Parasitol Int 58:201-9. 2009
Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials, chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health problem in many endemic regions...
- Return of chloroquine antimalarial efficacy in Malawi
Miriam K Laufer
University of Maryland School of Medicine, Baltimore, MD 21201, USA
N Engl J Med 355:1959-66. 2006
..The molecular marker of chloroquine-resistant falciparum malaria subsequently declined in prevalence and was undetectable by 2001, suggesting that chloroquine might once again be effective in Malawi...
- Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs
M J Doenhoff
School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Parasitology 136:1825-35. 2009
- Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum
Quinton L Fivelman
ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Antimicrob Agents Chemother 48:4097-102. 2004
..The relevance of in vitro interactions to in vivo treatment is discussed...
- Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
Juliana Martha Sá
Laboratory of Malaria and Vector Research and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:18883-9. 2009
..Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America...
- Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in Senegal
Department of Parasitology, Faculty of de Medicine, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Parasitol Res 109:133-8. 2011
..This study reveals that despite an increase in the prevalence of individual mutations, the IPT-SP coupled with the EPI has no major impact on DHFR and DHPS combined mutations...
- Drug resistance maps to guide intermittent preventive treatment of malaria in African infants
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Parasitology 138:1469-79. 2011
..There are clear deficiencies in molecular surveillance data coverage. We discuss requirements for ongoing surveillance of SP resistance markers in support of the use of SP-IPTi...
- Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
Amar bir Singh Sidhu
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Science 298:210-3. 2002
..pfcrt mutations increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hence, these antimalarials warrant further investigation as agents to control chloroquine-resistant falciparum malaria...
- Discordance in drug resistance-associated mutation patterns in marker genes of Plasmodium falciparum and Plasmodium knowlesi during coinfections
Rupesh K Tyagi
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
J Antimicrob Chemother 68:1081-8. 2013
..Human Plasmodium knowlesi infections have been reported from several South-East Asian countries, excluding India, but its drug susceptibility profile in mixed-infection cases remains unknown...
- Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
Department of Cardiology, Institut National de la Santè et de la Recherche Médicale Unité Mixte de Recherche 608, Hopital Universitaire Nord, Faculte de Medecine, Marseille, France
J Am Coll Cardiol 56:919-33. 2010
..This review provides a consensus opinion on the definition of high on-treatment platelet reactivity to ADP based on various methods reported in the literature and proposes how this measurement may be used in the future care of patients...
- Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population
Ana Maria Mejía
Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, University of London, United Kingdom
J Infect Dis 206:220-8. 2012
..They also demonstrate that T. cruzi has a propensity to undergo genetic changes that can lead to drug resistance, a finding that has implications for future therapeutic strategies.
- Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast
Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
PLoS ONE 6:e26005. 2011
..The emergence of artemisinin-resistant P. falciparum malaria in South-East Asia highlights the need for continued global surveillance of the efficacy of artemisinin-based combination therapies...
- The public health impact of chloroquine resistance in Africa
J F Trape
Laboratoire de Paludologie, Institut de recherche pour le developpement IRD, formerly ORSTOM, Dakar, Senegal
Am J Trop Med Hyg 64:12-7. 2001
..Here we review published data on the public health impact of antimalarial drug resistance in Africa...
- Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia
Institut Pasteur in Cambodia, Phnom Penh, Cambodia
Malar J 8:11. 2009
- Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data
Anne E P Frosch
Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD, USA
Malar J 10:116. 2011
..This observation suggests that there is continuing use of ineffective anti-malarials in Africa and that persistent chloroquine-resistant malaria is due to ongoing drug pressure despite national policy changes...
- Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
Lancet Infect Dis 12:851-8. 2012
..We investigated contributions of both parasite genetics and host factors to the artemisinin-resistance phenotype in Pursat, western Cambodia...
- Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens
J G Vontas
School of Biosciences, Cardiff University, Main College, Museum Avenue, P O Box 915, Cardiff CF10 3TL, Wales, UK
Biochem J 357:65-72. 2001
..lugens is through protecting tissues from oxidative damage. Our study extends the GSTs' range of efficacy to pyrethroid insecticides and possibly explains the role of elevated GSTs in other pyrethroid-resistant insects...
- Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine
Allen L Malisa
Department of Biological Sciences, Faculty of Science, Sokoine University of Agriculture, SUA, PO Box 3038, Morogoro, Tanzania
Malar J 9:190. 2010
..that drug coverage is the primary determinant of drug pressure and the driving force behind the evolution of drug resistance. These models show that where the basis of resistance is multigenic, the effects of selection can be ..
- Intrahost modeling of artemisinin resistance in Plasmodium falciparum
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
Proc Natl Acad Sci U S A 108:397-402. 2011
..This result supports the hypothesis that artemisinin resistance mainly reflects reduced ring-stage susceptibility and predicts that doubling the frequency of dosing will accelerate clearance of artemisinin-resistant parasites...
- In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda
Samuel L Nsobya
Department of Medicine, Makerere University, Kampala, Uganda
Antimicrob Agents Chemother 54:1200-6. 2010
..In summary, we demonstrated in parasites from Kampala a range of sensitivities to older drugs; correlation of sensitivities to CQ, MDAQ, and QN; and good activity against nearly all strains for DHA, LM, and PQ...
- Drug resistance in Indian visceral leishmaniasis
Kala Azar Medical Research Centre, Banaras Hindu University, Varanasi, India
Trop Med Int Health 6:849-54. 2001
..Lipid associated amphotericin B has an excellent safety and efficacy profile, but remains out of reach for most patients because of its high cost...
- Humans as the world's greatest evolutionary force
S R Palumbi
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Science 293:1786-90. 2001
..Slowing and controlling arms races in disease and pest management have been successful in diverse ecological and economic systems, illustrating how applied evolutionary principles can help reduce the impact of humankind on evolution...
- Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum
Daria Van Tyne
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Genet 7:e1001383. 2011
..Our GWAS and follow-on functional validation demonstrate the potential of genome-wide studies to elucidate functionally important loci in the malaria parasite genome...
- Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression
Hervé Le Nagard
INSERM Université Paris Diderot UMR 738, Paris, France
Comput Methods Programs Biomed 104:10-8. 2011
..This website is used by various teams in the world and the user can do the analysis without knowing R using the GUI. This article describes version 2.1 of this website and shows illustration on five different real examples...
- Schistosomiasis: challenges for control, treatment and drug resistance
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Curr Opin Infect Dis 19:577-82. 2006
..Despite shifts in global health policy towards the implementation of mass chemotherapeutic control programmes at the national scale in sub-Saharan Africa, however, many challenges still exist...
- In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 105:9059-64. 2008
..In addition, the screening method has the potential to provide the malaria community with many new starting points for the development of biological probes and drugs with novel antiparasitic activities...
- Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
L S Filardi
Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, Brazil
Trans R Soc Trop Med Hyg 81:755-9. 1987
..cruzi strains was also observed. Drug resistance was identified among T...
- High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia
Tim J C Anderson
Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
J Infect Dis 201:1326-30. 2010
- Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
Nicholas J White
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Malar J 8:253. 2009
Preventing the emergence of anti-malarial drug resistance is critical for the success of current malaria elimination efforts...
- Diversity of the sarco/endoplasmic reticulum Ca(2+)-ATPase orthologue of Plasmodium falciparum (PfATP6)
Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Infect Genet Evol 8:340-5. 2008
..In conclusion our findings show that PfATP6 is a more diverse gene than previously demonstrated. This natural variation may constitute a starting ground for artemisinin-driven progressive selection of resistant parasites...
- Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space
Naman K Shah
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
Lancet Infect Dis 11:57-64. 2011
..Strategies to reduce the emergence and spread of future drug resistance need to be proactive and supported by intensive monitoring.
- Unresolved issues in anthelmintic pharmacology for helminthiases of humans
Timothy G Geary
Institute of Parasitology, McGill University, Montreal, QC, Canada H9X 3V9
Int J Parasitol 40:1-13. 2010
..and soil-transmitted helminthiases in humans increases the urgency to better understand and better monitor drug resistance, and to broaden the currently very narrow range of available anthelmintics...
- p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma
Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
J Allergy Clin Immunol 109:649-57. 2002
..IL-2 combined with IL-4 can alter glucocorticoid receptor (GR) ligand-binding affinity and modulate glucocorticoid function...
- Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
PLoS ONE 6:e19283. 2011
..This study investigated the impact of different AS doses on clinical and parasitological responses in malaria patients from an area of known artemisinin resistance in western Cambodia...
- Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
Nat Genet 42:268-71. 2010
..Parasite half-maximum inhibitory concentrations for seven antimalarial drugs were obtained and used in GWAS to identify genes associated with drug responses. This study provides valuable tools and insight into the P. falciparum genome...
- Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Trends Parasitol 29:110-8. 2013
..Here, we review these findings and consider some new questions as well as future prospects for tackling the devastating diseases caused by these parasites...
- Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan
Najia Karim Ghanchi
Malaria Research Lab, Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital Karolinska Institutet, Retziusväg 10, Stockholm, Sweden
Malar J 10:18. 2011
Scarce data are available on Plasmodium falciparum anti-malarial drug resistance in Pakistan. The aim of this study was, therefore, to determine the prevalence of P...
- Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance
Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan tmita juntendo ac jp
Jpn J Infect Dis 65:465-75. 2012
..Elucidation of such markers would substantially contribute to the design of an effective policy for the containment of artemisinin resistance...
- On being the right size: the impact of population size and stochastic effects on the evolution of drug resistance in hospitals and the community
Roger D Kouyos
Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland
PLoS Pathog 7:e1001334. 2011
..the prevalence of antibiotic resistance, we use a stochastic epidemiological model describing the spread of drug resistance in a hospital setting as well as the interaction between one or several hospitals and the community...
- Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes
Burnham Institute for Medical Research, La Jolla, California, United States of America
PLoS ONE 4:e5046. 2009
- DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis
Helena I M Boshoff
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
Cell 113:183-93. 2003
..DNA polymerases, is the primary mediator of survival through inducible mutagenesis and can contribute directly to the emergence of drug resistance in vivo. These results may indicate a potential new target for therapeutic intervention.
- Anthelmintic resistance: markers for resistance, or susceptibility?
R N Beech
Institute of Parasitology, Macdonald College, McGill University, Ste Anne de Bellevue, QC H9X3V9, Canada
Parasitology 138:160-74. 2011
..Resistance may result from a loss of sensitivity as well as the appearance of resistance. A focus on the presence of anthelmintic susceptibility may be as important as the detection of resistance...
- Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: ev
Department of Immunology, Indian Institute of Chemical Biology, Kolkata
J Immunol 174:7160-71. 2005
..This is the first report of a vaccine conferring protection to both antimony responsive and resistant Leishmania strains reflecting several aspects of clinical visceral leishmaniasis...
- Prospective strategies to delay the evolution of anti-malarial drug resistance: weighing the uncertainty
David L Smith
Emerging Pathogens Institute and Department of Biology, University of Florida, Gainesville, 32611, USA
Malar J 9:217. 2010
The evolution of drug resistance in malaria parasites highlights a need to identify and evaluate strategies that could extend the useful therapeutic life of anti-malarial drugs...
- Artemisinins and the biological basis for the PfATP6/SERCA hypothesis
Centre for Infection, Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London, UK, SW17 0RE
Trends Parasitol 26:517-23. 2010
..Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere...
- Drug resistance in brain diseases and the role of drug efflux transporters
Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Bunteweg 17, D 30559 Hannover, Germany
Nat Rev Neurosci 6:591-602. 2005
..There is increasing evidence that drug efflux transporters have an important role in drug-resistant brain disorders, and this information should allow more efficacious treatment strategies to be developed...
- Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets
Xavier C Ding
Centre suisse de recherches scientifiques en Côte d Ivoire, 01 BP 1303, Abidjan 01, Cote d Ivoire
Trends Parasitol 27:73-81. 2011
- Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
Ric N Price
Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
Lancet 364:438-47. 2004
..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
- Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides
Institute of Parasitology, McGill University, Quebec, Canada
PLoS Negl Trop Dis 3:e397. 2009
..We have developed pyrosequencer assays for codon 200 (TTC or TAC) in A. lumbricoides and T. trichiura to screen for this single nucleotide polymorphism (SNP)...
- Polymorphism of PfATPase in Niger: detection of three new point mutations
Maman Laminou Ibrahim
Centre de Recherche Médicale et Sanitaire CERMES, BP 10887 Niamey, Niger
Malar J 8:28. 2009
..The goal of this work was to describe the baseline polymorphism of PfATPase6 gene in Niger, at a time when the national implementation of the ACT policy had just begun...
- Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate
Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Rangsit, Patumthani 12121, Thailand
Acta Trop 113:190-4. 2010
..Moreover, the correlation between pfmdr1 gene amplification and susceptibility of the parasite to MQ, QN and AS was observed (decreased susceptibilities to MQ, QN and AS in isolates with increased pfmdr1 copy number)...
- A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal
Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal
Am J Trop Med Hyg 82:228-30. 2010
The spread of Plasmodium falciparum drug resistance is outpacing new antimalarial development and compromising effective malaria treatment...
- Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum
Stephanie G Valderramos
Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
PLoS Pathog 6:e1000887. 2010
- Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs
Department of Parasitology, Faculty of Medicine, Iran University of Medical Sciences, 14496, Tehran, Iran
Parasitol Res 101:1319-22. 2007
..However, these resistant isolates were shown to be sensitive to miltefosine and paromomycin. The latter two drugs could thus be useful alternatives for the treatment of leishmaniasis in Iran even for SbV-resistant isolates...
- Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 54:2886-92. 2010
..Artemisinin resistance in western Cambodia is not linked to candidate genes, as was suggested by earlier studies...
- Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1
Amy L PicKard
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
Antimicrob Agents Chemother 47:2418-23. 2003
..001). Thus, measurement of pfmdr1 mutations and gene copy number may be useful for surveillance of mefloquine-resistant malaria in Southeast Asia...
- Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
Neekesh V Dharia
Department of Cell Biology, ICND 202, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
Genome Biol 10:R21. 2009
The identification of genetic changes that confer drug resistance or other phenotypic changes in pathogens can help optimize treatment strategies, support the development of new therapeutic agents, and provide information about the ..
- Reduced in vitro susceptibility to artemisinin derivatives associated with multi-resistance in a traveller returning from South-East Asia
Unité de Recherche en Biologie et Epidémiologie Parasitaires Unité de Recherche pour les Maladies Infectieuses et Tropicales Emergentes UMR 6236, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France
Malar J 10:268. 2011
- Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells
Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, India
Int J Parasitol 41:1311-21. 2011
..The above results reinforce the notion that antimony resistant parasites have undergone a number of biochemical and biophysical changes as part of their adaptation to ensure their survival in the host...
- Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis
University Health Network, Division of Cardiovascular Surgery, Toronto General Hospital
BMJ 336:195-8. 2008
..To determine if there is a relation between aspirin "resistance" and clinical outcomes in patients with cardiovascular disease...
- Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani
Division of Biological Chemistry and Molecular Biology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
J Biol Chem 279:39925-32. 2004
..These observations suggest ways in which current antimony therapies could be improved, overcoming the growing problem of antimony resistance...