cytoprotection

Summary

Summary: The process by which chemical compounds provide protection to cells against harmful agents.

Top Publications

  1. pmc The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells
    Elisabeth Walsby
    Department of Haematology, Institute of Cancer and Genetics, Cardiff University, School of Medicine, Heath Park, Cardiff, UK
    Oncotarget 3:525-34. 2012
  2. ncbi Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
    Mark T Gladwin
    Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Am J Physiol Heart Circ Physiol 291:H2026-35. 2006
  3. ncbi Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway
    Robert H Scannevin
    Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Pharmacol Exp Ther 341:274-84. 2012
  4. pmc Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study
    Michael Lichtenauer
    Department of Thoracic Surgery, Medical University Vienna, Vienna, Austria
    Basic Res Cardiol 106:1283-97. 2011
  5. pmc Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
    Bhavya Rao
    Centre for Oncology and Molecular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY Tayside, UK
    Oncotarget 1:639-50. 2010
  6. pmc Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
    Takehiko Dohi
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 27:17-28. 2007
  7. ncbi Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
    Chenhui Yang
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    Brain Res 1282:133-41. 2009
  8. ncbi Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection
    Z N Demidenko
    Brander Cancer Research Institute, New York Medical College, Valhalla, NY, USA
    Cell Death Differ 13:1434-41. 2006
  9. ncbi Mechanisms of cell protection by heme oxygenase-1
    Raffaella Gozzelino
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Annu Rev Pharmacol Toxicol 50:323-54. 2010
  10. ncbi Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress
    Hong Zhu
    Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA, 24060, USA
    Cardiovasc Toxicol 8:71-85. 2008

Detail Information

Publications284 found, 100 shown here

  1. pmc The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells
    Elisabeth Walsby
    Department of Haematology, Institute of Cancer and Genetics, Cardiff University, School of Medicine, Heath Park, Cardiff, UK
    Oncotarget 3:525-34. 2012
    ..Taken together these findings indicate that Hsp90 inhibition is an attractive therapeutic strategy in CLL...
  2. ncbi Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
    Mark T Gladwin
    Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Am J Physiol Heart Circ Physiol 291:H2026-35. 2006
    ..potential roles in intravascular endocrine nitric oxide (NO) transport, hypoxic vasodilation, signaling, and cytoprotection after ischemia-reperfusion...
  3. ncbi Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway
    Robert H Scannevin
    Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Pharmacol Exp Ther 341:274-84. 2012
    ..The clinical utility of DMF in multiple sclerosis is being explored through phase III trials with BG-12, which is an oral therapeutic containing DMF as the active ingredient...
  4. pmc Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study
    Michael Lichtenauer
    Department of Thoracic Surgery, Medical University Vienna, Vienna, Austria
    Basic Res Cardiol 106:1283-97. 2011
    ..Intravenous infusion of culture supernatant of apoptotic PBMC attenuates myocardial remodelling in experimental AMI models. This effect is probably due to the activation of pro-survival signalling cascades in the affected cardiomyocytes...
  5. pmc Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
    Bhavya Rao
    Centre for Oncology and Molecular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY Tayside, UK
    Oncotarget 1:639-50. 2010
    ..We propose that drugs that incorporate into DNA during S-phase may perform better as second drugs than mitotic poisons in cyclotherapy approaches using LDActD as a cytostatic agent...
  6. pmc Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
    Takehiko Dohi
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 27:17-28. 2007
    ..Therefore, differential phosphorylation of survivin by PKA in subcellular microdomains regulates tumor cell apoptosis via its interaction with XIAP...
  7. ncbi Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
    Chenhui Yang
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    Brain Res 1282:133-41. 2009
    ..This study evaluated the time course expression regularity of Nrf2, HO-1 and the curcumin's role in cerebral ischemia and its potential mechanism...
  8. ncbi Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection
    Z N Demidenko
    Brander Cancer Research Institute, New York Medical College, Valhalla, NY, USA
    Cell Death Differ 13:1434-41. 2006
    ..We next compared cytoprotection by GA-induced Hsp70, caspase inhibitors (Z-VAD-fmk) and cell-cycle arrest...
  9. ncbi Mechanisms of cell protection by heme oxygenase-1
    Raffaella Gozzelino
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Annu Rev Pharmacol Toxicol 50:323-54. 2010
    ..This cytoprotective effect inhibits the pathogenesis of a variety of immune-mediated inflammatory diseases...
  10. ncbi Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress
    Hong Zhu
    Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA, 24060, USA
    Cardiovasc Toxicol 8:71-85. 2008
    ..However, the role of this transcription factor in myocardiac cytoprotection against oxidative and electrophilic stress remains unknown...
  11. pmc Translating cell survival and cell longevity into treatment strategies with SIRT1
    K Maiese
    Department of Neurology and Neurosciences, Cancer Center, F 1220, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Rom J Morphol Embryol 52:1173-85. 2011
    ....
  12. ncbi Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    Kiwon Ban
    TMDT 3 904, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Endocrinology 151:1520-31. 2010
    ..the GLP-1R agonist exendin-4 and reveal the existence of a GLP-1(9-36)amide-responsive, exendin(9-39)-sensitive, cardioprotective signaling pathway distinct from that associated with the classical GLP-1 receptor...
  13. pmc LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection
    Hua Yuan
    BioScience Center, San Diego State University, San Diego, CA, USA
    Am J Physiol Heart Circ Physiol 296:H470-9. 2009
    ..These findings support the notion that autophagy is a cytoprotective response to LPS-induced cardiomyocyte injury; additional studies are needed to determine the therapeutic implications...
  14. pmc Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3
    Karol Szczepanek
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mitochondrion 12:180-9. 2012
    ..by targeting complex I as a proximal site in the electron transport chain (ETC) in order to favor the cytoprotection. The second part of the review highlights the emerging role of signal transducer and activator of ..
  15. pmc Novel insights into hydrogen sulfide--mediated cytoprotection
    John W Calvert
    Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Antioxid Redox Signal 12:1203-17. 2010
    ..This review also provides a detailed description of the current signaling mechanisms shown to be responsible for these cardioprotective actions...
  16. ncbi Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    Circulation 106:2973-9. 2002
    ..Erythropoietin (EPO) is a critical regulator for the proliferation of immature erythroid precursors, but its role as a potential cytoprotectant in the cerebrovasculature system has not been defined...
  17. pmc Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
    A Kenneth MacLeod
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Carcinogenesis 30:1571-80. 2009
    ..This study also shows that AKR1B10, AKR1C1 and AKR1C2 proteins have potential utility as biomarkers for NRF2 activation in the human...
  18. ncbi Nitric oxide priming protects nitric oxide-mediated apoptosis via heme oxygenase-1 induction
    Byung Min Choi
    Medicinal Resources Research Center MRRC, School of Medicine, Wonkwang University, Chonbuk, South Korea
    Free Radic Biol Med 34:1136-45. 2003
    ..However, the mechanism of cytoprotection has not been defined completely...
  19. pmc The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium
    Prajitha Thampi
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e34468. 2012
    ..5-HT(1A) receptor agonists may have potential as therapeutic agents in the treatment of retinal degenerative disease...
  20. pmc Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection
    Sarah E Hardison
    Department of Biology, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 0062, USA
    Am J Pathol 176:774-85. 2010
    ..These studies indicate that phenotype, as opposed to quantity, of infiltrating macrophages correlates with protection against pulmonary C. neoformans infection...
  21. ncbi Cytoprotection by lithium and valproate varies between cell types and cellular stresses
    Justin S Lai
    Laboratory of Cellular and Molecular Pathophysiology, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur J Pharmacol 539:18-26. 2006
    ....
  22. pmc A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes
    Henry Dube
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 441:901-7. 2012
    ..There is evidence [Malouitre, Dube, Selwood and Crompton (2010) Biochem. J. 425, 137-148] that cytoprotection by the CyP inhibitor CsA (cyclosporin A) is improved by selective targeting to mitochondria...
  23. ncbi Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents
    Prakash Jagtap
    Inotek Corporation, Beverly, MA 01915, USA
    Crit Care Med 30:1071-82. 2002
    ....
  24. ncbi Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase
    Qiang Xu
    Department of Geriatrics, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China
    Biochem Biophys Res Commun 388:389-94. 2009
    ..These results provide new insight into the protective properties of resveratrol against endothelial dysfunction caused by high glucose, which is attributed to the AMPK mediated reduction of superoxide level...
  25. pmc Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression
    Yi Zheng
    Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, PR China
    Mol Vis 16:1467-74. 2010
    ....
  26. pmc The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid
    Yong Zhou
    Department of Pediatrics Gastroenterology, Baylor College of Medicine, Houston, Texas, USA
    Biochim Biophys Acta 1788:507-13. 2009
    ..Thus, changes in cell membrane composition, such as CHOL content, potentially influence the efficacy of UDC as the primary drug used to treat cholestasis...
  27. ncbi The emerging biology of the nitrite anion
    Mark T Gladwin
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 1:308-14. 2005
    ..A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics...
  28. ncbi Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia
    Petra Szoleczky
    CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 1102, USA
    Arch Biochem Biophys 517:53-70. 2012
    ..Thus purine nucleoside supplementation holds promise in the treatment of acute renal failure...
  29. ncbi Heavy metal ions in normal physiology, toxic stress, and cytoprotection
    Michael A Lynes
    University of Connecticut, 91 N Eagleville Road, Storrs, CT 06269, USA
    Ann N Y Acad Sci 1113:159-72. 2007
    ..In this minireview, we will consider both the biological responses to stressful levels of heavy metal cations, and experimental and clinical manipulations of these cations as a means to improve human health parameters...
  30. ncbi UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo
    Ute Wölfle
    Competence Center skintegral, Department of Dermatology, University Medical Center Freiburg, D 79102 Freiburg, Germany
    Free Radic Biol Med 50:1081-93. 2011
    ..These data suggest that luteolin may protect human skin from UVB-induced damage by a combination of UV-absorbing, DNA-protective, antioxidant, and anti-inflammatory properties...
  31. ncbi L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin
    Kee Hyung Park
    Department of Neurology, Gachon University Gil Hospital, Inchon, Republic of Korea
    Neurotoxicology 32:879-87. 2011
    ..These results indicate that EPO can prevent L-DOPA neurotoxicity by activating the PI3K pathway as well as reducing oxidative stress...
  32. pmc Ocular neuroprotection by siRNA targeting caspase-2
    Z Ahmed
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Cell Death Dis 2:e173. 2011
    ....
  33. ncbi The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine
    Saman Hewamana
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 14:8102-11. 2008
    ..Here we elucidated the mechanism of action of LC-1, evaluated its relative cytotoxicity in prognostic subsets, and investigated its potential synergistic interaction with fludarabine...
  34. pmc Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells
    Bin Zhong
    Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Mol Cancer Ther 9:1831-41. 2010
    ..These results identify a previously unrecognized pathway linking AKT to cytoprotection by sCLU in tumor cells.
  35. pmc Inhaled carbon monoxide provides cerebral cytoprotection in pigs
    Vicki L Mahan
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41982. 2012
    ..Collectively, our data demonstrate that inhaled CO may be beneficial in preventing cerebral injury resulting from DHCA and offer important therapeutic options in newborns undergoing DHCA for open heart surgery...
  36. ncbi Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II
    Despina Harbilas
    Department of Pharmacology, Universite de Montreal, Centre Ville Station, Montreal, QC H3C 3J7, Canada
    Can J Physiol Pharmacol 87:479-92. 2009
    ..The present study revealed that Gaultheria hispidula, Rhododendron tomentosum, and Vaccinium vitis-idaea exhibit a promising profile of antidiabetic potential and are good candidates for more in-depth evaluation...
  37. pmc Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells
    Gang Lu
    Department of Pathology and Lab Medicine, University of Cincinnati, Cincinnati, OH 45220, USA
    Cardiovasc Res 88:277-86. 2010
    ..cells with insulin-like growth factor-1 (IGF-1) translocated connexin-43 (Cx-43) into mitochondria, causing cytoprotection. We posit that these preconditioning effects could be simulated by mitochondria-specific overexpression of Cx-..
  38. pmc Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia
    Xiaoying Wang
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, 149 13th Street, Room 2411A, Charlestown, MA 02129, USA
    Stroke 39:1869-74. 2008
    ..Emerging data suggest that neuroglobin (Ngb) may protect against hypoxic/ischemic neuronal insults. However, the underlying mechanisms in vivo and implications for long-term outcomes are still not well understood...
  39. pmc Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms
    Hongxia Shen
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences Fudan University, Shanghai 200032, China
    Neurobiol Dis 37:711-22. 2010
    ..Taken together, our results suggest that EP confers potent neuroprotection against neonatal H-I brain injury via its anti-cell death and anti-inflammatory actions. EP is a potential novel therapeutic agent for neonatal H-I brain injury...
  40. ncbi The Wnt signaling pathway protects retinal ganglion cell 5 (RGC-5) cells from elevated pressure
    Miryam A Fragoso
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, FL 33136, USA
    Cell Mol Neurobiol 31:163-73. 2011
    ..Therefore, activation of the Wnt pathway by Wnt3a could be investigated further as a tool to develop novel molecular therapeutic strategies for the prevention of RGC death in retinal disease...
  41. pmc Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation
    Sylvanie Malouitre
    Research Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 425:137-48. 2010
    ..that CyP-D has a major pathogenic role in 'energy failure', but not in glutamate excitotoxicity, where cytoprotection primarily reflects CsA interaction with extramitochondrial CyPs and calcineurin...
  42. pmc High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells
    Thierry Pauloin
    Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    Mol Vis 15:577-83. 2009
    ..The aim of this study was to investigate high molecular weight hyaluronan (HMW-HA) protection on human corneal epithelial (HCE) cells against ultraviolet B (UVB) radiation-induced toxic effects...
  43. ncbi Discovery of the negative regulator of Nrf2, Keap1: a historical overview
    Ken Itoh
    Department of Stress Response Science, Hirosaki University Graduate School of Medicine, Japan
    Antioxid Redox Signal 13:1665-78. 2010
    ..We propose that Nrf2-Keap1 plays a significant physiological role in the response to endogenous, environmental, and pharmacological electrophiles...
  44. ncbi Protective effect of clusterin from oxidative stress-induced apoptosis in human retinal pigment epithelial cells
    Jeong Hun Kim
    Fight against Angiogenesis Related Blindness Laboratory, Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Invest Ophthalmol Vis Sci 51:561-6. 2010
    ..This study was conducted to investigate whether clusterin protects human RPE cells from ROS-induced apoptosis through a PI3K/Akt survival pathway...
  45. pmc Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair
    Suping Wang
    Department of Neurology, S 507 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 39:2587-95. 2008
    ..The objective of this study was to determine the neuroprotective effects of NAD(+) repletion against ischemic injury and the underlying mechanism...
  46. ncbi Isoflurane preconditioning ameliorates endotoxin-induced acute lung injury and mortality in rats
    Qi Fang Li
    Department of Anesthesiology, Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Anesth Analg 109:1591-7. 2009
    ..We investigated the effect of preadministration of isoflurane on ALI induced by lipopolysaccharide (LPS) in rats...
  47. ncbi Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protection
    Gil Saeng Jeong
    Medicinal Resources Research Institute and Department of Microbiology and Immunology, Wonkwang University, Iksan 570 749, Korea
    Exp Mol Med 38:393-400. 2006
    ..groups in the ortho position on the aromatic ring was suggested to be essential to enhance HO-1 expression and cytoprotection in human endothelial cells...
  48. ncbi TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo
    Li Cheng
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada
    J Neurosci 22:3977-86. 2002
    ..These data provide proof-of-principle that enhancing the capacity of injured neurons to respond to trophic factors can be an effective neuroprotective strategy in the adult CNS...
  49. pmc Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species
    Scott A Reisman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 108:35-47. 2009
    ..In conclusion, the present study suggests that increased activation of hepatic Nrf2 is more important for the detoxification and elimination of electrophiles than reactive oxygen species...
  50. ncbi Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis
    Markus Mair
    Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria
    Gastroenterology 138:2499-508. 2010
    ....
  51. pmc Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury
    Man Jiang
    Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Pathol 176:1181-92. 2010
    ..Together, the results demonstrated autophagy induction during hypoxic and ischemic renal injury. Under these pathological conditions, autophagy may provide a protective mechanism for cell survival...
  52. pmc HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
    Sanjeev Gupta
    Apoptosis Research Centre, School of Natural Sciences, NUI Galway, Galway, Ireland
    PLoS Biol 8:e1000410. 2010
    ..Our data show that binding of Hsp72 to IRE1alpha enhances IRE1alpha/XBP1 signaling at the ER and inhibits ER stress-induced apoptosis. These results provide a physical connection between cytosolic chaperones and the ER stress response...
  53. pmc Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
    Changhan Lee
    Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, Los Angeles, California 90089 0191, USA
    Cancer Res 70:1564-72. 2010
    ..We conclude that normal cells and mice can be protected against chemotherapy-dependent damage by reducing circulating IGF-I levels and by a mechanism that involves downregulation of proto-oncogene signals...
  54. ncbi Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait
    Louis C Martineau
    Department of Pharmacology and Membrane Protein Study Group, Universite de Montreal, and Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, QC, Canada
    Phytomedicine 13:612-23. 2006
    ..Enhancement of proliferation in beta cells may represent another potential anti-diabetic property. Extracts of the Canadian blueberry thus show promise for use as a complementary anti-diabetic therapy...
  55. ncbi The role of alphaA- and alphaB-crystallins in the survival of retinal ganglion cells after optic nerve axotomy
    Yasunari Munemasa
    Jules Stein Eye Institute, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Invest Ophthalmol Vis Sci 50:3869-75. 2009
    ..The authors analyzed the expression of alphaA- and alphaB-crystallins in a rat optic nerve transection (ONT) model characterized by specific retinal ganglion cell (RGC) degeneration and determined their role in RGC survival...
  56. pmc The Wnt signaling pathway: aging gracefully as a protectionist?
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pharmacol Ther 118:58-81. 2008
    ....
  57. ncbi Clusterin activates survival through the phosphatidylinositol 3-kinase/Akt pathway
    Hayet Ammar
    Biochemistry Department, Institute of Pathology B23, Avenue de l Hopital, 3, University of Liege, Liege 4000, Belgium
    J Biol Chem 283:12851-61. 2008
    ..These results enable us to pinpoint one mechanism by which secreted clusterin favors survival in androgen-independent prostate cancer cells, implicating its receptor megalin and Akt survival pathway...
  58. pmc Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
    Sruti Shiva
    Vascular Medicine Branch, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:2089-102. 2007
    ..Although the mechanism of nitrite-mediated cytoprotection is unknown, NO is a mediator of the ischemic preconditioning cell-survival program...
  59. pmc Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
    Amy Trott
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA
    Mol Biol Cell 19:1104-12. 2008
    ....
  60. ncbi Mechanisms of hair cell death and protection
    Alan G Cheng
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Opin Otolaryngol Head Neck Surg 13:343-8. 2005
    ..Current knowledge of these cell death mechanisms and potential therapeutic targets are discussed in this review...
  61. ncbi Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
    ..Strikingly, the change in neuronal gene expression after tBHQ treatment was dependent on Nrf2 activity in the astrocytes. This suggests that Nrf2-dependent genetic changes alter neuron-glia interactions resulting in neuroprotection...
  62. ncbi DP-b99, a membrane-activated metal ion chelator, as neuroprotective therapy in ischemic stroke
    Hans Christoph Diener
    Department of Neurology, University Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Stroke 39:1774-8. 2008
    ..We present the results of a multicenter, double-blind, placebo-controlled, randomized trial to assess the safety and potential protective effects of DP-b99 in acute ischemic stroke...
  63. pmc Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion
    L Breivik
    Department of Biomedicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway
    Basic Res Cardiol 106:135-45. 2011
    ..In conclusion, the IPC effluent retains strong cardioprotective properties, containing hydrophobic mediator(s) < 30 kDa offering cytoprotection via PI3K/Akt-dependent signaling at ischemic reperfusion.
  64. pmc Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects
    Ruiping Song
    Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 163:231-42. 2003
    ..the stress response gene heme oxygenase-1 (HO-1) and/or its catalytic by-product carbon monoxide (CO) confers cytoprotection against tissue and cellular injury...
  65. ncbi Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
    Paul H Yancey
    Biology Department, Whitman College, Walla Walla, WA 99362, USA
    J Exp Biol 208:2819-30. 2005
    ..Some of these solutes have applications in biotechnology, agriculture and medicine, including in vitro rescue of the misfolded protein of cystic fibrosis. However, caution is warranted if high levels cause overstabilization of proteins...
  66. pmc Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress
    Yan Chen Shang
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    Cell Signal 22:1317-29. 2010
    ..Our work highlights Wnt1 and the control of novel downstream transcriptional pathways as critical components for the oversight of nervous system microglial cells...
  67. pmc Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
    Yaping Liu
    Nuclear Receptor Functional Analysis, High Thruput Biology, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 112:1678-87. 2003
    ..The hepatoprotection seen in these animal models by the synthetic FXR agonist suggests FXR agonists may be useful in the treatment of cholestatic liver disease...
  68. ncbi Autophagy protects renal tubular cells against cyclosporine toxicity
    Nicolas Pallet
    INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, Paris, France
    Autophagy 4:783-91. 2008
    ..Taken together, these results demonstrate that CsA, through ER stress induction, activates autophagy as a protection against cell death...
  69. ncbi Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB)
    Midori A Yenari
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, United States
    Neurochem Int 49:164-9. 2006
    ..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK...
  70. ncbi Erythropoietin protects retinal pigment epithelial cells from oxidative damage
    Zhao yang Wang
    The School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Free Radic Biol Med 46:1032-41. 2009
    ....
  71. ncbi Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death
    Yang Jin
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    FASEB J 23:341-50. 2009
    ..Taken together, Cav-1/Cyr61 interaction via integrins represents a novel pathway of Cyr61 signaling involving cav-1-dependent processes, which play a critical role in regulating hyperoxia-induced cell death...
  72. ncbi Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress
    Yunbo Li
    Davis Heart and Lung Research Institute, Department of Internal Medicine and Division of Cardiovascular Medicine, The Ohio State University Medical Center, Columbus, 43210, USA
    Pharmacol Res 53:6-15. 2006
    ..The results of this study thus suggested a new mechanism, which might contribute to the cardiovascular protective effects of resveratrol...
  73. pmc Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls
    Zuzana Majkova
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0200, USA
    Toxicol Appl Pharmacol 251:41-9. 2011
    ..Our data implicate A₄/J₄-NPs as mediators of omega-3 fatty acid-mediated protection against the endothelial toxicity of coplanar PCBs...
  74. ncbi Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes
    Stuart A Rushworth
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Biochem Biophys Res Commun 341:1007-16. 2006
    ..In summary, curcumin activates ARE-mediated gene expression in human monocytes via PKC delta, upstream of p38 and Nrf2...
  75. ncbi Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1
    F Ali
    Bywaters Centre for Vascular Inflammation, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK
    J Thromb Haemost 5:2537-46. 2007
    ..This led to an investigation of the role of HO-1 in statin-mediated cytoprotection in primary human endothelial cells (ECs), and the ability of Kruppel-like factor 2 (KLF2) to regulate HO-1 ..
  76. ncbi Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1
    Byung Min Choi
    Medicinal Resources Research Center MRRC and the Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea
    Hepatology 37:810-23. 2003
    ..cytotoxicity; zinc protoporphyrin (ZnPP) IX, an inhibitor of HO, was found to block the SNP-induced cytoprotection. SNP increased the induction of HO-1 protein as well as its activity in hepatocytes...
  77. ncbi Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection
    Tareisha Dunlap
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA
    Chem Res Toxicol 20:1903-12. 2007
    ..These results indicate a strategy for studying the quinone biological activity and reinforce the therapeutic attributes of NO-ASA through structural elements other than NO and ASA...
  78. ncbi Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Neurobiol Dis 37:441-54. 2010
    ....
  79. pmc Nitrite as a mediator of ischemic preconditioning and cytoprotection
    Daniel Murillo
    Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Nitric Oxide 25:70-80. 2011
    ..Nitric oxide (NO) and more recently nitrite (NO(2)(-)) are known to modulate mitochondrial function, mediate cytoprotection after IR and have been implicated in the signaling of the highly protective ischemic preconditioning (IPC) ..
  80. ncbi Prospective randomised trial of amifostine cytoprotection in myeloma patients undergoing high-dose melphalan conditioned autologous stem cell transplantation
    A Spencer
    Clinical Haematology and BMT, The Alfred Hospital, Melbourne, Australia
    Bone Marrow Transplant 35:971-7. 2005
    ..We conclude that amifostine can be safely administered prior to high-dose melphalan and significantly reduces the frequency and severity of therapy-induced oral mucositis...
  81. ncbi Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury
    Yanggang Yuan
    Department of Nephrology, Nanjing Children s Hospital, Institute of Pediatrics, Nanjing Medical University, Nanjing, China
    Kidney Int 82:771-89. 2012
    ..Activators of SIRT1, such as resveratol, may be therapeutically useful in glomerular diseases to promote and maintain PGC-1α expression and, consequently, podocyte integrity...
  82. ncbi Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress
    T Nishimura
    Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Placenta 31:1003-9. 2010
    ..MeAIB, a system A specific substrate, inhibited hypertonic stress-induced [(14)C]betaine uptake. These results suggest that TauT and system A play cytoprotective roles in syncytiotrophoblasts exposed to hypertonic stress...
  83. ncbi Alternate delivery route for amifostine as a radio-/chemo-protecting agent
    Natalie P Praetorius
    College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA
    J Pharm Pharmacol 60:809-15. 2008
    ..This review will primarily focus on the variety of more recently studied (2002 and later) alternative modes for amifostine administration, including subcutaneous, intrarectal and oral routes...
  84. ncbi Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection
    Kotaro Okamoto
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical University, 2 1, Midorigaoka Higashi, Asahikawa, Hokkaido 078 8510, Japan
    Int J Colorectal Dis 27:1039-46. 2012
    ..The purpose of this study is to determine the CSF effect on reducing intestinal inflammation...
  85. ncbi Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy
    Dominique Kranz
    Medical Biotechnology Center, Institute for Medical Biology, University of Southern Denmark, Odense, Denmark
    Cancer Res 66:10274-80. 2006
    ..We propose that the cell cycle arrest function of p53 can be used to convert p53 from a killer to a protector of cells, with the potential to reduce unwanted side effects of chemotherapy...
  86. ncbi Cytoprotection against ischemia-induced DNA cleavages and cell injuries in the rat liver by pro-vitamin C via hydrolytic conversion into ascorbate
    Masahiro Eguchi
    Division of Cell Biochemistry, Hiroshima Prefectural University School of BioSciences, Nanatsuka, Shobara, Hiroshima, Japan
    Mol Cell Biochem 252:17-23. 2003
    ..Thus, hepatic I/R injuries were shown to be prevented more markedly by Asc2G or Asc2P than by Asc, which is attributable to efficiencies of both vitamin C conversion and subsequent AscR retention...
  87. ncbi p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro
    Nils Schallner
    Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
    Eur J Pharmacol 670:58-66. 2011
    ..The molecular mechanism underlying this effect remains controversial. We hypothesized that CORM-2 mediates cytoprotection via induction of heat shock proteins through activation of p38 mitogen-activated kinase...
  88. pmc Protective effect of canolol from oxidative stress-induced cell damage in ARPE-19 cells via an ERK mediated antioxidative pathway
    Xin Dong
    Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, P R China
    Mol Vis 17:2040-8. 2011
    ..This study was conducted to investigate the protective effect of canolol against oxidative stress-induced cell death in ARPE-19 cells and its underlying mechanism...
  89. ncbi Loss of myocardial LIF receptor in experimental heart failure reduces cardiotrophin-1 cytoprotection. A role for neurohumoral agonists?
    Natalia Lopez
    Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Spain
    Cardiovasc Res 75:536-45. 2007
    ....
  90. ncbi Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice
    K Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto, Japan
    J Pharmacol Exp Ther 297:1160-5. 2001
    Endogenous prostaglandins (PGs) play a central role in adaptive cytoprotection induced in the stomach by mild irritants...
  91. ncbi Chemoprotective and radioprotective effects of amifostine: an update of clinical trials
    R L Capizzi
    Jefferson Medical College, Philadelphia, PA, USA
    Int J Hematol 72:425-35. 2000
    ..Amifostine has demonstrated broad-spectrum cytoprotection against myelotoxicity, nephrotoxicity, xerostomia, and mucositis associated with various chemotherapy and ..
  92. ncbi delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation
    Anika Heiss
    Institute of Pharmacology, Toxicology and Pharmacy Ludwig Maximilians University of Munich Koeniginstrasse 16, 80539 Muenchen, Federal Republic of Germany
    Exp Cell Res 315:2115-25. 2009
    ..Taken together, these results demonstrate that in NG108-15 hybrid cells DOR agonists possess cytoprotective properties mediated by activation of the RTK/PI3K/Akt signaling pathway...
  93. pmc Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture
    Pasha Apontes
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Oncotarget 2:222-33. 2011
    ....
  94. pmc Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
    MALU G TANSEY
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30324, USA
    Neurobiol Dis 37:510-8. 2010
    ....
  95. ncbi Elevated expression of hexokinase II protects human lung epithelial-like A549 cells against oxidative injury
    Aftab Ahmad
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Physiol Lung Cell Mol Physiol 283:L573-84. 2002
    ..The present study demonstrates that HK-II protects human lung epithelial-like A549 cells against oxidative insults by protecting the mitochondria...
  96. ncbi A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system
    Masamichi Katori
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Los Angeles, CA 90095, USA
    Transpl Immunol 9:227-33. 2002
    ..The role of the HO system as a novel strategy to mitigate an antigen-independent ischemia/reperfusion injury has been documented in a number of transplantation models...
  97. pmc Mammalian stanniocalcin-1 activates mitochondrial antioxidant pathways: new paradigms for regulation of macrophages and endothelium
    David Sheikh-Hamad
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Renal Physiol 298:F248-54. 2010
    ..Our data suggest that STC1 activates antioxidant pathways in endothelial cells and macrophages and displays cytoprotective and anti-inflammatory actions...
  98. ncbi Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage
    Lalini Reddy
    Department of Biotechnology, Durban Institute of Technology, Durban 4000, South Africa
    Biol Chem 387:87-93. 2006
    ..Our results demonstrate that HepG2 cells pretreated with lycopene and beta-carotene are protected from the toxic effects of AFB1 at both the cellular and molecular levels...
  99. ncbi Angiopoietin-1 protects H9c2 cells from H2O2-induced apoptosis through AKT signaling
    Zuoyan Wang
    Department of Cardiology, Peking University Third Hospital, Beijing 100083, China
    Biochem Biophys Res Commun 359:685-90. 2007
    ..This effect could be reversed by AKT inhibition. These results suggest that Ang1 protects cardiomyocytes from oxidative stress-induced apoptosis by regulating the activity of AKT...
  100. pmc Dynamic analyses reveal cytoprotection by RPE melanosomes against non-photic stress
    Janice M Burke
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226 4812, USA
    Mol Vis 17:2864-77. 2011
    ..The aim of this study was to determine whether retinal pigment epithelium (RPE) melanosomes are competent to protect cultured cells against non-photic oxidative stress induced by treatment with H(2)O(2)...
  101. ncbi PI3K/Akt signaling pathway-induced heme oxygenase-1 upregulation mediates the adaptive cytoprotection of hydrogen peroxide preconditioning against oxidative injury in PC12 cells
    Liqiu Mo
    Department of Physiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, P R China
    Int J Mol Med 30:314-20. 2012
    ..Although we have demonstrated that hydrogen peroxide (H2O2) preconditioning confers adaptive cytoprotection against oxidative stress-induced injury in PC12 cells, it remains unknown whether these defense systems are ..

Research Grants72

  1. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..R-801 behaves as a mitochondrial-selective K+-ATP channel opener, providing profound cytoprotection without induction of hyperglycemia and diastolic hypotension...
  2. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..This cytoprotection was associated with inhibition of the mitochondrial electrogenic Ca2+/Fe2+ uniporter...
  3. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..that have well established roles in physiologic and pathologic processes such as renal perfusion, gastric cytoprotection, hemostasis, cancer, host defense, inflammation, and asthma...
  4. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..that, in SCD, HIF-1[unreadable] activation will contribute to altered vascular tone and reactivity and confer cytoprotection against reperfusion injury by modulating expression of vasoactive/cytoprotective molecules (e.g., HO-1)...
  5. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2013
    ..We have shown that retinoid signaling is engaged during 11-deoxy-16,16-dimethyl PGE2 (DDM-PGE2) mediated cytoprotection against reactive oxygen species (ROS) induced necrotic/oncotic cell death...
  6. Nrf2 as a Master Regulator in Liver Disease Prevention and Therapy
    Curtis D Klaassen; Fiscal Year: 2012
    ..The importance of Nrf2 in cytoprotection is recognized. Nevertheless, the role of Nrf2 in liver pathophysiology has just recently gained attention...
  7. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms
    ERIK MILLS SCHWIEBERT; Fiscal Year: 2010
    ..will document botanically- derived raw extracts, extract fractions, and purified small molecules for 'cytoprotection'versus 'cytotoxicity...
  8. Hypertension, Kidney and Pregnancy
    Joey P Granger; Fiscal Year: 2013
    ..There is mounting evidence that HO-1 and/or its catalytic products confer cytoprotection against cellular injury in response to placental ischemia, an important initiating event in the ..
  9. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Similarly, in vitro Nrf2 activation in human COPD lung cells has shown improved cytoprotection, improved bacterial clearance, and restoration of steroid sensitivity...
  10. Neuroprotection by Mitochondria-targeted Antioxidants
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2013
    ..Specifically, we will: (i) Design and synthesize MTAs and assess their cytoprotection in neuronal cell culture models of PD, (ii) Determine the molecular mechanisms of cytoprotection of MTAs in ..
  11. Gene Regulation by and of LEDGF
    Dhirendra P Singh; Fiscal Year: 2012
    ..trimeric HSF1 during stress that cooperatively transactivates the heat shock genes - an interaction that leads cytoprotection;(b) LEDGF and HSF1 interaction is essential for cell survival under stress, as Hsf1 depleted cells, despite ..
  12. Pleiotropic Transcription Factors As Target For Intracerebral Hemorrhage Treatmen
    Jaroslaw A Aronowski; Fiscal Year: 2012
    ..Preliminary data suggest: (1) Cytoprotection: Activators of Nrf2 after ICH in rodents reduce oxidative stress, inflammation, and protect brain cells from ..
  13. Neuroprotection from ETOH-mediated apoptosis: Nrf2/ARE control of GSH homeostasis
    George I Henderson; Fiscal Year: 2013
    ..profiles of controlling components of GSH homeostasis, their responses to E, the role of Nrf2 and 3GT in cytoprotection from E, and means to enhance this neuroprotection...
  14. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
    ..that using the Nrf2-/- mice, of which Nrf2 is known to be a transcriptional factor that plays critical role in cytoprotection against inflammation and oxidative stresses, Nrf2-deficient mice were found to be more susceptible to ..
  15. CYTOPROTECTIVE EFFECTS OF INFLAMMATION MEDIATED MEMBRANE REPAIR
    DOUGLAS LOWELL MANN; Fiscal Year: 2013
    ..of Specific Aims 1 - 3 will provide definitive information with respect to the mechanisms for TRAF2-mediated cytoprotection in the heart, as well as allow us to determine whether dysferlin, a novel Ca++ dependent emergency response ..
  16. Endogenous Hemoglobin And Heme Detoxification After Intracerebral Hemorrhage
    Xiurong Zhao; Fiscal Year: 2013
    ..Next, we will optimize the strategy for efficient endocytosis of hemolytic products and for cytoprotection via combining SF with M-CSF or DEX in an "ICH-like" injury model in primary neuron-glial co-cultures prepared ..
  17. Molecular Targeting of the Survivin Pathway in Cancer
    Dario C Altieri; Fiscal Year: 2010
    ..Inhibitor of Apoptosis (IAP) gene family that has attracted attention for its dual role in cell division and cytoprotection, and its overexpression in nearly every human tumor...
  18. The Role of Heme Oxygenase-1 in the Immune Response
    James F George; Fiscal Year: 2013
    ..unique molecular target, heme oxygenase-1 (HO-1), which is part of a group of stress proteins shown to provide cytoprotection. HO-1 is unique among these proteins because of its association with immunomodulation, and protection against ..
  19. Cardiomyocyte Apoptosis and Cardioprotective Actions of Estrogen
    Jin Kyung Kim; Fiscal Year: 2013
    ..We suspect that both ER subtypes (ER[unreadable] and ER[unreadable]) are necessary for full cytoprotection from mitochondria-centered apoptosis...
  20. Regulation and function of Cyr61 in hyperoxia induced acute lung injury
    Yang Jin; Fiscal Year: 2010
    ..Studies, we hypothesize that Cyr61 expression is regulated by hyperoxia transcriptionally and confers cytoprotection against hyperoxia via Akt related pathways...
  21. VEGF receptor-1-mediated protection in dilated cardiomyopathy
    Fabio A Recchia; Fiscal Year: 2013
    ..goal of the present project is to test the hypothesis that VEGFR-1 is the main mediator of VEGF-induced cytoprotection in hearts with non-ischemic dilated cardiomyopathy...
  22. Nrf2 signaling and oxidative stress in Age-related macular degeneration
    James T Handa; Fiscal Year: 2013
    ..the synthetic triterpenoid derivatives of oleonolic acid, which represent a promising new class of agents for cytoprotection from oxidative injury...
  23. ADENOSINE AND ANTIOXIDANT ENZYMES
    Vickram Ramkumar; Fiscal Year: 1999
    ..While the mechanism of cytoprotection is not clear, we have recently demonstrated that adenosine and an analog R-phenylisopropyl adenosine (R-PIA) ..
  24. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..nature (signaling through tumor necrosis factor receptor associated factor 2 [TRAF2]), and (2) study a novel method for conferring cytoprotection in cardiac myocytes through enhanced membrane repair following ischemia reperfusion injury.
  25. Intracellular targeting Hsp70 for pulmonary cytoprotection after toxin inhalation
    Richard Weisbart; Fiscal Year: 2013
    ..as an intracellular transporter to deliver heat-shock protein 70 (Fv-Hsp70) into cells, and we demonstrated cytoprotection against oxidative damage in vitro and in vivo...
  26. BRP-39/YKL-40 in Th2 Inflammation and Asthma
    Jack A Elias; Fiscal Year: 2013
    ..is associated with enhanced T cell and macrophage apoptosis and Fas expression and (c) BRP-39/YKL-40-induced cytoprotection is associated with enhanced protein kinase B/Akt activation...
  27. FASEB Summer Research Conference titled "THE LUNG EPITHELIUM IN HEALTH AND DISEAS
    MICHAEL FRANCIS BEERS; Fiscal Year: 2010
    ..Molecular mechanisms mediating acute lung epithelial injury and its repair;(5) Paradigms for lung epithelial cytoprotection including ER stress, autophagy, and programmed cell death;(6) Molecular and genetic pathways underlying ..
  28. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly-Rosen; Fiscal Year: 2013
    ..We plan to determine whether ethanol-induced cytoprotection requires 5PKC and ALDH2 activity, using genetically manipulated mice (AIM 1A)...
  29. NEW FUNCTION SERPIN PAI 2 AS A REGULAR OF RB
    Toni Antalis; Fiscal Year: 2009
    ..Based on the connections between PAI-2 cytoprotection and Rb anti-apoptotic activities, we initiated work on determining molecular mechanisms underlying PAI-2 ..
  30. Mechanisms of Pulmonary Mast Cell Recruitment and Maturation
    MICHAEL FAGERSTEN GURISH; Fiscal Year: 2012
    ..IL-9 (through proliferation and cytoprotection) and TNFa (through induction of VCAM-1) are necessary for the early accumulation of MCp in the allergen-..
  31. Radiation Protectors and Radiation Therapy Coupled Chemoprevention
    David J Grdina; Fiscal Year: 2013
    ..possess anti-mutagenic properties at doses 4- to 16- fold lower than those required to demonstrate classical cytoprotection. We will determine the maximum non- cytoprotective doses of these TCC agents in mice having 4 day old FSa "..
  32. MOLECULAR CONTROL OF EGF RECEPTOR DOWN-REGULATION
    Hamid Band; Fiscal Year: 2012
    ..ErbB receptors also mediate cytoprotection from chemotherapy and radiation, and represent targets for radio- and chemo-sentization of tumors...
  33. Ischemia-reperfusion injury in transplantation: novel cytoprotection strategies
    Reza Abdi; Fiscal Year: 2013
    ..The findings from this proposal could be easily translated into clinical practice and have a significant impact on reducing the burden of IRI in clinical transplantation. ..
  34. Mechanisms of tumor resistance to anti-HER/ErbB therapeutics
    Zhen Fan; Fiscal Year: 2012
    ..xenografts;3) to elucidate the EpoR downstream signaling pathways through activation of which rHuEPO mediates cytoprotection against trastuzumab;and 4) to confirm the presence of HER2 and EpoR co-expression and to determine its ..
  35. Autophagy & Functional Restoration of Irradiated Salivary Glands
    KIRSTEN H contact LIMESAND; Fiscal Year: 2010
    ..use of small molecule therapeutic approaches, we wish to investigate whether activation of autophagy leads to cytoprotection or exacerbation of radiation-induced injury to salivary tissues...
  36. Heme Oxygenase-1/Carbon Monoxide in Lung Vascular Injury
    Augustine M Choi; Fiscal Year: 2013
    ..following aims: Specific Aim #1: To determine the mechanism by which CO-induced autophagy functions to provide cytoprotection in experimental PH Specific Aim 2: To determine the mechanism by which CO dampens the inflammasome pathway in ..
  37. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD MICHAEL LOPACHIN; Fiscal Year: 2013
    ..This cytoprotection could include inhibition of both the endogenous disease process and the exacerbating actions of exogenous type-..
  38. The Role of the EGF Receptor in Acute and Chronic Renal Injury
    Raymond Harris; Fiscal Year: 2013
    ..Aim #3 will examine the role of membrane-associated EGFR ligands in the maintenance and cytoprotection of renal epithelial cells...
  39. Epo regulated erythropoiesis
    Don Wojchowski; Fiscal Year: 2012
    ..Important new actions of erythropoietin (EPO) are increasingly being realized in the contexts of ischemic cytoprotection, angiogenesis, thrombosis and the anemia of cancer and chemotherapy...
  40. Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
    Machiko Ikegami; Fiscal Year: 2012
    ..Furthermore, the molecular mechanisms, in particular the signaling pathways regulating Cebpa, of recombinant human FGF-7 treatment for acute lung injury will be determined. ..
  41. Hypoxia and cardiac stem cell homing
    Yao Liang Tang; Fiscal Year: 2012
    ..be utilized to increase CSC homing via regulation of CXCR4 expression and enhance survival of homed cells via cytoprotection in acute ischemic myocardium...
  42. Heme Oxygenase-1/Carbon Monoxide in sepsis
    Augustine M Choi; Fiscal Year: 2013
    ..of CO in sepsis Specific Aim 2: To determine the mechanism by which CO-induced autophagic pathway mediates cytoprotection in experimental sepsis Specific Aim 3: To perform proof-of-concept studies for biomarker detection and ..
  43. Regulation of Tumorigenesis and therapeutic resistance by Nrf2 in lung cancer
    Shyam Biswal; Fiscal Year: 2013
    ..the expression of electrophile/ xenobiotic detoxification enzymes and drug efflux proteins and confers cytoprotection against oxidative stress and apoptosis in normal cells...
  44. EGR-1: Regulator of apoptosis and inflammation in COPD
    Augustine M Choi; Fiscal Year: 2010
    ..provide potent anti-apoptotic and anti-inflammatory effects, critical in the adaptive and stress response of cytoprotection against cigarette smoke. PROJECT NARRATIVE...
  45. Proximal tubule Kim-1 expression modulates acute and chronic kidney injury
    CRAIG ROBERT BROOKS; Fiscal Year: 2013
    ..Our preliminary data suggest that Kim-1-mediated phagocytosis induces autophagy and cytoprotection in PTCs following acute kidney injury...
  46. The Cytoskeletal System in Preservation Injury
    Martin J Mangino; Fiscal Year: 2013
    ..This proposal will test likely mechanisms of ezrin-induced cytoprotection in cell and kidney cold storage injury models by using molecular and genetic approaches to alter ezrin ..
  47. Post Transcriptional Control of hemorrhagic iron damage.
    Jack T Rogers; Fiscal Year: 2013
    ..Both ferritin and APP confer cytoprotection as active ferroxidases converting Fe2+ to its storage form of Fe3+...
  48. ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
    Daniel J Klionsky; Fiscal Year: 2013
    ..provided by applicant): Autophagy represents a complex pathway of cellular homeostasis that functions in cytoprotection, but if dysregulated can cause cell death;a complete knowledge of regulation is critical for the potential ..
  49. Angiomyogenesis with HIF-1a responsive microRNAs
    RAFEEQ HABEEBAHMED; Fiscal Year: 2012
    ..Our proposal will be the first to elucidate the mechanistic participation of HRMs in paracrine behavior, angiomyogenic potential and cytoprotection.
  50. Carbon Monoxide: Novel Opportunities for Therapy
    Mark A Perrella; Fiscal Year: 2013
    ..cellular mechanism(s) by which a toxic molecule when administered at low physiologic doses can provide potent cytoprotection ii) identify novel molecular targets of CO which can by themselves be a platform for the development of both ..
  51. Biosynthesis and Trafficking of Surfactant Protein C In Health and Disease
    MICHAEL FRANCIS BEERS; Fiscal Year: 2013
    ..focusing on 3 emerging themes critical to lung cell biology: protein trafficking, organelle homeostasis, and cytoprotection. Specific Aim 1 will focus on defining the role of 4 key factors, the SP-C NH2 PPDY motif, Nedd4-2 WW domains, ..
  52. ESOPHAGEAL CYTOPROTECTION--AGENTS AND MECHANISMS
    Roy Orlando; Fiscal Year: 2009
    ..This effort coupled with the studies above should provide new insights into the pathogenesis of RE. ..
  53. ABetaPP Influences Cerebral Thrombosis
    William E Van Nostrand; Fiscal Year: 2013
    ..participate in variety of neuroprotective activities ranging from proteinase inhibition to ligand binding to cytoprotection. For example, it is known that shortly following stroke there is a marked increase in the expression of A[..
  54. Reversal of apoptosis:an in vivo mechanism for cytoprotection and mutagenesis
    Denise J Montell; Fiscal Year: 2013
    ..The proposed work has the potential to lead to a new understanding of and treatments for degenerative diseases and cancer. ..
  55. MOLECULAR MECHANISMS OF RENAL INJURY
    Volker H Haase; Fiscal Year: 2013
    ..To understand the molecular and cellular basis of cytoprotection, we have begun to use genetic and pharmacologic approaches to dissect cell type-specific HIF functions and ..
  56. Targeting colorectal carcinogenesis using a cinnamon-derived food factor
    Donna D Zhang; Fiscal Year: 2013
    ..responsible for potent induction of the Nrf2-regulated antioxidant response in human colon cells, conferring cytoprotection against subsequent oxidative and genotoxic insult...
  57. Carbon monoxide therapy for severe pulmonary arterial hypertension
    Roberto F Machado; Fiscal Year: 2013
    ..Accumulating evidence suggests that carbon monoxide (CO) confers potent cytoprotection via anti-inflammatory, anti-proliferative and anti-apoptotic effects, processes critical for repair and ..
  58. N-terminus of sAPP Regulates Abeta Assembly
    William E Van Nostrand; Fiscal Year: 2013
    ..participate in variety of neuroprotective activities ranging from proteinase inhibition to ligand binding to cytoprotection. For example, during the previous funding period we unequivocally demonstrated that the Kunitz proteinase ..
  59. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ..should add new understanding of basic mechanisms of endothelial injury and pave the way for development of protective measures (cytoprotection) to avert the initiation of fibrin seeding on the endothelial cells and their desquamation.
  60. Checkpoint Abrogation and MEK 1/2 Inhibition in Myeloma
    Steven Grant; Fiscal Year: 2013
    ..non-cycling G0G1 and primary MM cells to this strategy;3) define the basis by which these regimens circumvent cytoprotection by Mcl-1, a critical MM survival factor, and use genetic and pharmacologic strategies to determine whether ..
  61. Structures of membrane-bound Bcl-2 apoptotic proteins
    Francesca Marassi; Fiscal Year: 2009
    ..phosphorylation, myristoylation) and interactions (with other Bcl-2 proteins;with non-homologous partners), as we attempt to further understand the structural basis for apoptosis induction and cytoprotection by Bcl-2 family proteins.
  62. Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    Feroz R Papa; Fiscal Year: 2013
    ..Our project goal is to study these switches at the molecular level using interventional approaches. ..
  63. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2007
    ..Our laboratories and others have demonstrated that the induction of HO-1 provides cytoprotection both in vivo and in vitro against multiple modes of injury including endotoxemia, ischemia/reperfusion, and ..
  64. The heat shock response and cytoprotection
    Hector Wong; Fiscal Year: 2006
    ....
  65. MYOGENIC DISORDERS OF THE GALLBLADDER
    Jose Behar; Fiscal Year: 2004
    ..that human AC develops in a permissive GB environment characterized by GB stasis and impaired muscle cytoprotection that allows biliary aggressive factors to initiate the inflammatory process...
  66. SYNTHESIS ANTI-HIV AGENTS THAT TARGET ZINC FINGERS
    MARK WELKER; Fiscal Year: 2000
    ..Nine of the heterocycles the investigators have synthesized to date are active in their XTT cytoprotection anti-HIV-1 assay and most are also zinc ejectors (NCp7 Trp37 assay)...
  67. A Novel Cytoprotective Peptide for GI Epithelial Cell
    FREDERICK TOBACK; Fiscal Year: 2005
    ..To determine if these biological effects of AMP peptide confer colonic cytoprotection in vivo, its effectiveness was tested in two important animal models of barrier compromise, IBD and GDS...
  68. Oral Antioxidant/Anticytokine Therapy for ALD
    Daniell Hill; Fiscal Year: 2005
    ..g. Kupffer cells) and which attenuate liver metabolic abnormalities and enhance cytoprotection in target cells (e.g. hepatocytes)...
  69. MECHANISMS OF ETHANOL-INDUCED CARDIAC PROTECTION
    Daria Mochly Rosen; Fiscal Year: 2009
    ..We plan to determine whether ethanol-induced cytoprotection requires 5PKC and ALDH2 activity, using genetically manipulated mice (AIM 1A)...
  70. 5ASA REGULATION OF MNSOD IN INTESTINAL CELLS
    John Valentine; Fiscal Year: 2002
    ..In this proposal, we are using antisense MnSOD to document the role of MnSOD in 5-ASA induced cytoprotection in cell culture...
  71. A new approach to xenotransplantation in primate
    Juan Contreras; Fiscal Year: 2005
    ..To accomplish this goal, we will establish in diabetic primates, a strategy for islet cytoprotection and tolerance induction to isolated adult porcine pancreatic islets...
  72. Pre-Conditioning Pancreatic Islets for Transplantation
    Ginny Bumgardner; Fiscal Year: 2006
    ..The proof of concept that hypoxia preconditioning initiates a cytoprotection cascade which reduces redox stress has been established for a variety of (nonpancreatic) cell types and ..