- Matching native electrical stimulation by graded chemical stimulation in isolated mouse adrenal chromaffin cells
Department of Physiology and Biophysics, School of Medicine, 2109 Adelbert Road, Case Western Reserve University, Cleveland, OH 44106 4970, USA
J Neurosci Methods 166:195-202. 2007
..We address this limitation in the current study. We describe a bulk chemical stimulation paradigm calibrated to match defined electrical activity...
- Single olfactory sensory neurons simultaneously integrate the components of an odour mixture
Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS, UMR 5020, Universite Claude Bernard, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
Eur J Neurosci 18:2690-6. 2003
- Representation of odor habituation and timing in the hippocampus
Sachin S Deshmukh
National Centre for Biological Sciences, Gandhi Krishi Vignana Kendra Campus, Bangalore 560065, India
J Neurosci 23:1903-15. 2003
..This may act as a neuronal substrate for habituation and for complex tasks such as odor-guided navigation...
- Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation
I J Lever
Neuroscience Research Center and Department of Pharmacology, Guy's, King's, and St. Thomas' School of Biomedical Sciences, King's College London, London SE1 1UL, United Kingdom
J Neurosci 21:4469-77. 2001
..Here we show that BDNF is released in the rat isolated dorsal horn after chemical stimulation by capsaicin or electrical stimulation of dorsal roots...
- Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists
L S Sorkin
Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
Pain 77:181-90. 1998
..Removal of each influence may model a different component of neuropathic pain...
- Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip
Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 E 57th Street, Chicago, IL, USA
Lab Chip 10:2147-53. 2010
- Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex--an experimental model for vascular dysfunctions in cluster headache
Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
Cephalalgia 24:206-14. 2004
..was developed in the rat to measure changes in lacrimation and intracranial blood flow following noxious chemical stimulation of facial mucosa...
- Metallic taste from electrical and chemical stimulation
Harry T Lawless
Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA
Chem Senses 30:185-94. 2005
..5-3 V) was not affected by nasal occlusion. This difference suggests two distinct mechanisms for evocation of metallic taste reports, one dependent upon retronasal smell and a second mediated by oral chemoreceptors...
- Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa
Institute of Pharmacology and Toxicology, University Erlangen Nurnberg, F R G
Electroencephalogr Clin Neurophysiol 71:241-50. 1988
..Responses to the mixture of carbon dioxide and vanillin appeared significantly earlier (50-150 msec) than responses to either substance alone...
- Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice
Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
BMC Neurosci 4:5. 2003
- Responses of nerve fibres of the rat saphenous nerve neuroma to mechanical and chemical stimulation: an in vitro study
Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, San Juan de Alicante, 03550 Alicante, Spain
J Physiol 527:305-13. 2000
..They became mechanically sensitive after chemical stimulation. These findings show that neuroma nerve endings in the rat saphenous nerve neuroma in vitro are ..
- Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal
G C D Eichenberger
Faculdade de Medicina de Ribeirao Preto, Departamento de Farmacologia, Universidade de Sao Paulo, Lab de Neuroanatomia e Neuropsicobiologia, Avenida dos Bandeirantes 3900, 14049 900, Ribeirao Preto, Brazil
Neuropharmacology 42:48-59. 2002
..antagonists on the aversive responses elicited by electrical (at the freezing and escape thresholds) or chemical stimulation (crossings, rearings, turnings and jumps, induced by microinjections of bicuculline) of the midbrain tectum ..
- A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function
John I Glendinning
Department of Biological Science, Barnard College, Columbia University, New York, NY 10027, USA
Chem Senses 27:461-74. 2002
..This screen represents a significant improvement over the common two-bottle preference test because it assesses taste function more specifically and in a fraction of the time...
- Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors
Department of Neuroscience, University of Pennsylvania School of Medicine, 215 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
Nat Neurosci 10:348-54. 2007
- The rostral ventrolateral medulla mediates the sympathoactivation produced by chemical stimulation of the rat nasal mucosa
P F McCulloch
Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
J Physiol 516:471-84. 1999
1. We sought to outline the brainstem circuit responsible for the increase in sympathetic tone caused by chemical stimulation of the nasal passages with ammonia vapour...
- Individual mouse taste cells respond to multiple chemical stimuli
Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
J Physiol 544:501-9. 2002
..Thus, there appears to be no strict and separate detection of taste qualities by distinct subpopulations of taste cells in peripheral gustatory sensory organs in mice...
- Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists
Departments of Pharmacology and Anesthesiology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
J Neurosci 28:11593-602. 2008
..These studies propose possible therapeutic exploitation of a novel mechanism providing pain relief by CB(1) inverse agonists...
- Neural representation of bitter taste in the nucleus of the solitary tract
Christian H Lemon
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, 38163, USA
J Neurophysiol 94:3719-29. 2005
..Thus central neurons most responsive to bitter substances receive significant input from receptors that mediate other tastes, indicating that bitter stimuli are not represented by activity in specifically tuned neurons...
- Taste-specific neuronal ensembles in the gustatory cortex of awake rats
Donald B Katz
Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
J Neurosci 22:1850-7. 2002
..These data suggest that taste-specific GC assemblies may transiently form and coevolve on a behaviorally appropriate timescale, contributing to rats' ability to discriminate tastants...
- Spinal substance P immunoreactivity is enhanced by acute chemical stimulation of the rat prostate
Department of Urology, Yamagata University School of Medicine, Yamagata, Japan
Urology 59:139-44. 2002
..SP is considered a mediator of nociception in the spinal cord. Immunoreactivity of SP is enhanced after acute chemical stimulation of somata.
- The contribution of taste bud populations to bitter avoidance in mouse strains differentially sensitive to sucrose octa-acetate and quinine
Steven J St John
Department of Psychology, Reed College, Portland, OR 97202, USA
Chem Senses 29:775-87. 2004
..These findings are discussed with regard to the distribution in the oral cavity of putative taste receptors for quinine and SOA and the peripheral organization of bitter taste...
- Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes
Euan A Ashley
University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
Circulation 105:3011-6. 2002
..Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction...
- Modulation of human swallowing behaviour by thermal and chemical stimulation in health and after brain injury
Department of GI Sciences, Hope Hospital, Salford, UK
Neurogastroenterol Motil 15:69-77. 2003
Few data support thermal or chemical stimulation as therapy for neurogenic dysphagia...
- Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice
Nixon M Abraham
WIN Group of Olfactory Dynamics, Heidelberger Akademie der Wissenschaften and Max Planck Institut für medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
Neuron 44:865-76. 2004
..The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed...
- Speed and accuracy of olfactory discrimination in the rat
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nat Neurosci 6:1224-9. 2003
- Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes
Dipartimento di Biologia, Universita di Roma Tor Vergata, 00133 Rome, Italy
J Neurosci 20:RC76. 2000
..Dendritic mRNA recruitment onto polysomes in response to synaptic stimulation might represent one of the mechanisms underlying the processes of learning and memory...
- Dynamic and multimodal responses of gustatory cortical neurons in awake rats
D B Katz
Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
J Neurosci 21:4478-89. 2001
- Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 24:8310-21. 2004
- Distribution of gustatory sensitivities in rat taste cells: whole-cell responses to apical chemical stimulation
T A Gilbertson
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808-4124, USA
J Neurosci 21:4931-41. 2001
..4%) to three, and 8 (13.6%) to all of the basic stimuli. Cells with both inward (Na(+)) and outward (K(+)) voltage-activated currents were significantly more broadly tuned to gustatory stimuli than those with only inward currents...
- Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat
Robert J Hayes
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Psychopharmacology (Berl) 168:75-83. 2003
..In animals, the BLC is necessary for cocaine-seeking behavior elicited by cocaine-associated cues. It has not been determined whether BLC activation is sufficient to reinstate cocaine seeking...
- Effects of osmolarity on taste receptor cell size and function
Department of Physiology, Virginia Commonwealth University, Richmond 23298, Virginia, USA
Am J Physiol 277:C800-13. 1999
..These data suggest that the osmolyte-induced increase in the CT response to NaCl involves a sustained decrease in TRC volume and the activation of amiloride-sensitive apical Na(+) channels...
- Facilitation of voluntary swallowing by chemical stimulation of the posterior tongue and pharyngeal region in humans
Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University, Morioka 020 8505, Japan
Neurosci Lett 448:139-42. 2008
- Mechanism of heart rate responses elicited by chemical stimulation of the hypothalamic paraventricular nucleus in the rat
Department of Neurological Surgery, MSB H 586, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
Brain Res 1248:115-26. 2009
..Experiments were done in urethane-anesthetized, barodenervated, adult, male Wistar rats. Chemical stimulation of the PVN by unilateral microinjections of N-methyl-d-aspartic acid (NMDA) elicited increases in HR which ..
- Encoding and decoding of overlapping odor sequences
Bede M Broome
Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, 91125, USA
Neuron 51:467-82. 2006
..Thus, PN population dynamics are history dependent, and responses of individual KCs are consistent with piecewise temporal decoding of PN output over large sections of the PN population...
- Encoding social signals in the mouse main olfactory bulb
Da Yu Lin
HHMI and Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 434:470-7. 2005
..We conclude that mitral cells represent natural odorant stimuli by acting as selective feature detectors, and that their activation is largely independent of the presence of other components in the olfactory stimulus...
- State-dependent modulation of time-varying gustatory responses
Volen National Center for Complex Systems, MS 013, Brandeis University, 415 South Street, Waltham, MA 02454, USA
J Neurophysiol 96:3183-93. 2006
..These data suggest that neural state changes can change the content of neural codes...
- Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli
Department of Physiology and Biophysics and Program in Neuroscience, University of Miami School of Medicine, Miami, Florida 33136, USA
J Neurosci 23:9947-52. 2003
..The reduced behavioral sensitivity to bitter stimuli in alpha-gustducin knock-out mice thus appears to be the consequence of a reduced number of bitter-activated taste cells, as well as reduced sensitivity...
- Analysis of training-induced changes in ethyl acetate odor maps using a new computational tool to map the glomerular layer of the olfactory bulb
Department of Cell and Developmental Biology, University of Colorado School of Medicine, Mail Stop 8108 PO Box 6511, Aurora, CO 80045, USA
Chem Senses 30:615-26. 2005
..The software generates odor maps (density plots) based on glomerular activity, density, or area. We find that training up-regulates the number of glomeruli that become c-fos positive after stimulation with ethyl acetate...
- Modulation of parabrachial taste neurons by electrical and chemical stimulation of the lateral hypothalamus and amygdala
Cheng Shu Li
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Science Center, 855 Monroe Ave, Suite 515, Memphis, TN 38163, USA
J Neurophysiol 93:1183-96. 2005
..This neural substrate is likely involved in the modulation of taste activity by physiological and experiential factors...
- Cardiovascular responses elicited by chemical stimulation of the rostral ventrolateral medulla in conscious, unrestrained rats
Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham, U K
J Auton Nerv Syst 31:185-90. 1990
- Functional magnetic resonance imaging in rats subjected to intense electrical and noxious chemical stimulation of the forepaw
U I Tuor
Biosystems, Institute for Biodiagnostics, National Research Council, 435 Ellice Avenue, Manitoba, R3B 1Y6, Winnipeg, Canada
Pain 87:315-24. 2000
..fMRI combined with appropriate exploratory data analysis tools could provide an effective new tool with which to study novel analgesics and their effects on the CNS processing of pain in animal models...
- Cardiovascular responses to chemical stimulation of the lateral tegmental field and adjacent medullary reticular formation in the rat
Department of Neurosurgery, MSB H 586, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103 2757, USA
Brain Res 977:247-60. 2003
Relatively few studies have been done to characterize cardiovascular responses to the chemical stimulation of sites located in the medullary lateral tegmental field (LTF) and most of them have been carried out in anesthetized animals...
- GABAA-Receptor blockade reverses the injury-induced sensitization of nociceptor-specific (NS) neurons in the spinal dorsal horn of the rat
Department of Physiology, University of Alcala, Madrid, Spain
J Neurophysiol 96:661-70. 2006
..This provides evidence for a mechanism in which an enhanced GABAergic transmission can lead to hyperexcitability and sensitization of NS neurons in the dorsal horn...
- Effect of amiloride on gustatory responses in the ventroposteromedial nucleus of the thalamus in rats
Justus V Verhagen
College of Sciences, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 1010, USA
J Neurophysiol 93:157-66. 2005
..Thus membership in a neuronal group retains functional significance based on a receptor event 4 synapses away...
- Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli
Laura C Geran
Section of Oral Biology, College of Dentistry, Ohio State University, 305 W 12th Ave Postle Hall, Columbus, OH 43210, USA
J Neurophysiol 96:2513-27. 2006
..These results indicate heterogeneity for the processing of ionic and nonionic bitter tastants, which is dependent on receptive field. Further, they suggest that neurons selective for bitter substances could contribute to taste coding...
- Chorda tympani responses in two inbred strains of mice with different taste preferences
M E Frank
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
Physiol Behav 67:287-97. 1999
..Nonetheless, genes involved in the structuring of taste receptors and/or the chordae tympani, which transduce taste stimuli having diverse perceptual qualities, differ for the two mouse strains...
- Dynamic coding of taste stimuli in the brainstem: effects of brief pulses of taste stimuli on subsequent taste responses
Patricia M Di Lorenzo
Department of Psychology, State University of New York at Binghamton, Binghamton, New York 13902, USA
J Neurosci 23:8893-902. 2003
..Dynamic tuning may be the result of inhibitory interactions within the NTS; cells that show dynamic tuning may have a unique function in taste coding...
- Hippocampal dopamine receptors modulate cFos expression in the rat nucleus accumbens evoked by chemical stimulation of the ventral hippocampus
Department de Farmàcia i Tecnología Farmacèutica, Facultat de Farmacia, Universitat de Valencia, Avda Vicente Andres Estelles s n, 46100 Burjassot, Valencia, Spain
Neuropharmacology 49:1067-76. 2005
..In contrast, raclopride had no significant effect. Our present results show that the NMDA receptor mediated effects in the VH require D1 receptors and suggest that DA in VH strongly modulates the excitatory outputs from this brain area...
- Three-dimensional estimation of the distribution and size of putative functional units in rat gustatory cortex as assessed from the inter-neuronal distance between two neurons with correlative activity
Department of Physiology, School of Dental Medicine, Aichi Gakuin University, Nagoya, Japan
Brain Res Bull 54:575-84. 2001
..In conclusion we point out that nearby neurons are prone to CA, if (1) their best tastes are identical, (2) their taste profiles are similar, and (3) the temporal patterns of taste response resemble each other...
- Hippocampal dopamine receptors modulate the motor activation and the increase in dopamine levels in the rat nucleus accumbens evoked by chemical stimulation of the ventral hippocampus
Department de Farmàcia i Tecnología Farmacèutica, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
Neuropsychopharmacology 30:843-52. 2005
A number of studies have shown that chemical stimulation (using N-methyl-D-aspartate (NMDA) infusions) or electrical stimulation of the ventral hippocampus (VH) elicits locomotor activation and sustained increases in nucleus accumbens (..
- Interactions between salt and acid stimuli: a lesson in gustation from simultaneous epithelial and neural recordings
S A Simon
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
J Gen Physiol 120:787-91. 2002
- Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons: role of cAMP/PKA signaling pathway
Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
J Neurophysiol 89:1985-93. 2003
The effect of prostaglandin E(2) (PGE(2)) on chemical stimulation-evoked calcium (Ca(2+)) transient was investigated in isolated vagal sensory neurons of the rat using fura-2-based ratiometric Ca(2+) imaging...
- Evidence for a role of basal ganglia in the regulation of rapid eye movement sleep by electrical and chemical stimulation for the pedunculopontine tegmental nucleus and the substantia nigra pars reticulata in decerebrate cats
Department of Physiology, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa 078 8510, Japan
Neuroscience 124:207-20. 2004
..An excessive GABAergic output from the basal ganglia to the PPN in parkinsonian patients may induce sleep disturbances, including a reduction of REM sleep periods and REM sleep behavioral disorders (REM without atonia)...
- Coordinate synaptic mechanisms contributing to olfactory cortical adaptation
Aaron R Best
Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
J Neurosci 24:652-60. 2004
..Importantly, in line with the in vitro findings, both adaptation of odor responses in the beta (15-35 Hz) spectral range and the associated synaptic depression can also be blocked by intracortical infusion of CPPG in vivo...
- Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL
Oral Cellular and Molecular Biology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Fukuoka 812 8582, Japan
J Endocrinol 180:193-201. 2004
- The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli
J Amiel Rosenkranz
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 23:11054-64. 2003
..This may be attributable to the loss of PFC-imposed inhibition of the emotional response to a stimulus but may also include the formation or diminished extinction of inappropriate associations...
- Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain
A Florence Keller
Unite de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, QC G1J 2G3, Canada
Mol Pain 3:27. 2007
..But, a central unresolved question is whether this disinhibition can transform the activity and responses of spinal nociceptive output neurons to account for the symptoms of neuropathic pain...
- Long-term recordings from afferent taste fibers
Department of Physiology, School of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
Physiol Behav 80:309-15. 2003
..These changes in response characteristics were hypothesized to result from changes in the taste receptor cells as the receptor cells turnover in the taste buds...
- Early odor preference learning in the rat: bidirectional effects of cAMP response element-binding protein (CREB) and mutant CREB support a causal role for phosphorylated CREB
Division of Basic Medical Sciences, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
J Neurosci 23:4760-5. 2003
..They support evidence that CREB overexpression can be deleterious and suggest the hypothesis of an optimal pCREB window for learning...
- [The dentate gyrus neurogenesis: a common therapeutic target for Alzheimer disease and senile depression?]
Lab for Alzheimer s Disease, Brain Science Institute, RIKEN
Seishin Shinkeigaku Zasshi 105:398-404. 2003
..Pseudodementia might also involve suppressed neurogenesis but differ form AD since the neurodegenerative process in AD may be irreversible...
- Dietary sodium deprivation reduces gustatory neural responses of the parabrachial nucleus in rats
Department of Physiology and Pathophysiology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi 710061, People s Republic of China
Neurosci Lett 432:170-3. 2008
..These findings suggest that dietary sodium deprivation might modulate sodium intake via increasing aversive threshold for salt rather enhancing salt discrimination...
- Blockade of NMDA receptors in prelimbic cortex induces an enduring amnesia for odor-reward associative learning
Neuromodulation and Memory Processes, Unite Mixte de Recherche 7102, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 75005 Paris, France
J Neurosci 23:5472-6. 2003
..These results underlie the role of NMDA receptors in the early stage of consolidation of a simple odor-reward associative memory and confirm the role of the PLC in the consolidation of long-term memory...
- Mucosal activity patterns as a basis for olfactory discrimination: comparing behavior and optical recordings
P F Kent
Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Brain Res 981:1-11. 2003
..9, P=nil). These results give additional credence to the concept that the odorant-induced mucosal activity patterns may serve as the substrate for the perception of odorant quality...
- Activation of purinergic receptor subtypes modulates odor sensitivity
Colleen C Hegg
Department of Physiology, University of Utah, Salt Lake City, Utah 84108 1297, USA
J Neurosci 23:8291-301. 2003
..Peripheral ATP-mediated odor suppression is a novel mechanism for reduced olfactory sensitivity during exposure to olfactotoxins and may be a novel neuroprotective mechanism...
- Kainate-induced excitation and sensitization of nociceptors in normal and inflamed rat glabrous skin
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
Neuroscience 137:999-1013. 2006
..The data indicate that peripheral kainate receptors not only play an important role in normal nociception but also contribute to mechanical sensitivity and heat sensitization accompanying inflammatory pain...
- Rat olfactory bulb mitral cells receive sparse glomerular inputs
Antoniu L Fantana
Molecular and Cellular Biology Department and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 59:802-14. 2008
..We conclude that mitral cells do not have center-surround receptive fields. Instead, each mitral cell performs a specific computation combining a small and diverse set of glomerular inputs...
- Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Gene Ther 10:1712-20. 2003
..These results demonstrate a new approach to engineer physiologically regulated insulin secretion by non-beta cells...
- Odor representations in the rat olfactory bulb change smoothly with morphing stimuli
Adil G Khan
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India
Neuron 57:571-85. 2008
..We suggest that our olfactory coding model captures many aspects of single and mixed odor representation in M/T cells...
- "Green odor" inhalation reduces the skin-barrier disruption induced by chronic restraint stress in rats: physiological and histological examinations
Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine, Yonago, Tottori 683, Japan
Chem Senses 32:633-9. 2007
- Effects of electrical stimulation of the glossopharyngeal nerve on cells in the nucleus of the solitary tract of the rat
Robert M Hallock
Department of Psychology, Box 6000, State University of New York at Binghamton, Binghamton, New York 13902 6000, USA
Brain Res 1113:163-73. 2006
..These differences may reflect the respective functional specializations of the GP and CT nerves...
- Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)
A B Dongmo
Laboratoire de Biologie des Organismes animaux, Faculte des Sciences, Université de Douala, BP 24157 Douala, Cameroun
J Ethnopharmacol 98:201-6. 2005
..Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities...
- Organization of electrically and chemically evoked defensive behaviors within the deeper collicular layers as compared to the periaqueductal gray matter of the rat
A S Bittencourt
Departamento de Ciencias Fisiologicas, Centro Biomedico, Edifício do Programa de Pós Graduação em Ciências Fisiológicas, Universidade Federal do Espirito Santo, Av Marechal Campos 1468 Maruípe, 29043 125 Vitória, ES, Brazil
Neuroscience 133:873-92. 2005
..b>Chemical stimulation employed a slow microinfusion of N-methyl-d-aspartic acid (NMDA, 0-2.3 nmol, 0.5 nmol/min)...
- Nicotine increases microdialysate brain amino acid concentrations and induces conditioned place preference
Vladimir A Kashkin
Valdman Institute of Pharmacology, Pavlov Medical University, St Petersburg, 197089, Russia
Eur Neuropsychopharmacol 15:625-32. 2005
..The same doses of nicotine were able to elicit a reinforcing effect in a CPP paradigm which was probably associated with the increased brain levels of excitatory acids triggering additional dopamine release in the mesolimbic system...
- L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells
Stephanie M Busque
Dept of Surgery, Yale University, New Haven, CT 06520, USA
Am J Physiol Gastrointest Liver Physiol 289:G664-9. 2005
..These data support the conclusion that amino acids, in conjunction with a physiological Ca(o)(2+) concentration, can induce acid secretion independent of hormonal stimulation via allosteric activation of the stomach CaSR...
- Growth-stimulating effect of kallikrein on rat neural stem cells--II. Immunocytochemical analysis and specificity of the enzyme for neural stem cells
Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science, Yamaguchi, Japan
Yakugaku Zasshi 127:919-22. 2007
..i.e., kallikrein administered into the body stimulates neural stem cell proliferation and new neurons may be generated from them...
- Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle-nerve preparations in vitro after eccentric contraction
Department of Neural Regulation, Division of Regulation of Organ Function, Research Institute of Environmental Medicine, Nagoya, Japan
J Neurophysiol 94:2822-31. 2005
..These results suggest that augmentation of the mechanical response in muscle thin-fiber sensory receptors might be related to the muscle tenderness in DOMS after ECC...
- Regulation of activin A and inhibin B secretion by inflammatory mediators in adult rat Sertoli cell cultures
Monash Institute of Medical Research, Monash University, Melbourne, Australia
J Endocrinol 187:125-34. 2005
..Interference with the complex interactions between these cytokines and hormones may contribute to the disruption of reproductive function that can accompany infection and illness in men...
- Species differences in the gut stimulatory effects of radish seeds
Muhammad Nabeel Ghayur
Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Sind, Pakistan
J Pharm Pharmacol 57:1493-501. 2005
- Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways
Michel F Otuki
Department of Pharmacology, Centre of Biological Sciences, Federal University of Santa Catarina, Campus Universitario Trindade, Bloco D CCB, Cx Postal 476, CEP 88049 900, Florianopolis, SC, Brazil
J Pharmacol Exp Ther 313:310-8. 2005
..The mechanisms involved in their action are not completely understood but seem to involve the inhibition of protein kinase A- and protein kinase C-sensitive pathways...
- Neurons in superficial trigeminal subnucleus caudalis responsive to oral cooling, menthol, and other irritant stimuli
Karen L Zanotto
Section of Neurobiology, Physiology and Behavior, University of California Davis, 1 Shields Ave, Davis, CA 95616, USA
J Neurophysiol 97:966-78. 2007
..The convergent nature of these units suggests a general role in signaling noxious stimuli...
- Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system
Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 24:3703-10. 2004
..These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors...
- Chemical factors determine olfactory system beta oscillations in waking rats
Catherine A Lowry
Committee on Neurobiology, Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA
J Neurophysiol 98:394-404. 2007
..Theta band coherence analysis shows that coupling strength between the olfactory bulb and piriform cortex increases linearly with vapor phase concentration, which may facilitate beta oscillations above a threshold...
- Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFbeta1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells
Yun Ju Chen
Institute of Physiology, School of Medicine, National Yang Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
J Endocrinol 192:405-19. 2007
..Furthermore, we demonstrate for the first time that TGFbeta1 acts in a rapamycin-hypersensitive and mTORC1-independent manner in augmenting FSH-stimulated steroidogenesis in rat granulosa cells...
- Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam
Iain S McGregor
School of Psychology, University of Sydney, Sydney, New South Wales 2006, Australia
J Neurosci 24:4134-44. 2004
..These findings also suggest the intriguing hypothesis that cat odor is processed by rats as a "pheromone-like" stimulus...
- Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons
Lehrstuhl fuer Zellphysiologie, Ruhr Universitaet Bochum, Universitaetsstr 150, 44780 Bochum, Germany
Eur J Neurosci 19:2497-510. 2004
..Therefore, we assume a functional role for the newly identified subpopulation in chemodetection of certain trigeminal stimuli...
- Olfaction in olfactory bulbectomized rats
Department of Psychology, University of South Florida, Tampa, Florida 33549, USA
J Neurosci 24:9195-200. 2004
..Our results provide strong support for the contention that, in the absence of the olfactory bulbs, olfactory connections to novel forebrain sites can support both odor detection and odor discrimination...
- Central neuropeptide B administration activates stress hormone secretion and stimulates feeding in male rats
W K Samson
Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
J Neuroendocrinol 16:842-9. 2004
- Stimulation of the parapyramidal region of the neonatal rat brain stem produces locomotor-like activity involving spinal 5-HT7 and 5-HT2A receptors
Department of Physiology, Spinal Cord Research Centre, University of Manitoba Winnipeg, Winnipeg, Canada
J Neurophysiol 94:1392-404. 2005
..region (PPR) of the mid-medulla produced locomotor-like activity as a result of either electrical or chemical stimulation, and PPR-evoked locomotor-like activity was blocked by antagonists to 5-HT2A and 5-HT7 receptors located on ..
- Responses of the rat olfactory epithelium to retronasal air flow
John W Scott
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Neurophysiol 97:1941-50. 2007
..The results also strongly support the importance of odorant sorption in normal olfactory processes...
- Differential covariation in taste responsiveness to bitter stimuli in rats
Susan M Brasser
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
Chem Senses 30:793-9. 2005
..More generally, these data reinforce the notion that bitter taste processing is not a homogeneous event...
- Injury-induced functional plasticity in the peripheral gustatory system
Susan J Hendricks
Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
J Neurosci 22:8607-13. 2002
- [Effect of nitric oxide on force-frequency relations in experimental hyperfunction and hypertrophy in the heart muscle]
T S Lahodych
National Medical University, Kiev
Fiziol Zh 47:3-10. 2001
..We conclude that the paradoxical response of hypertrophy of hearts is connected to infringements of redistribution of ions Ca between extracellular medium and intracellular stores in a systole and diastole...
- Corticotrophin-releasing hormone inhibits insulin-like growth factor-I release from primary cultures of rat granulosa cells
A E Calogero
Section of Endocrinology, Andrology and Internal Medicine, Department of Biomedical Sciences, University of Catania, Ospedale Garibaldi, Piazza S Maria de Gesú, 95123 Catania, Italy
J Endocrinol 174:493-8. 2002
..In conclusion, CRH suppressed the release of oestrogen and IGF-I, but not of IGFBP-3. Thus, the inhibitory effects of CRH on oestrogen release could be mediated, partly, by a suppression of the autocrine/paracrine action of IGF-I...
- Endothelin-stimulated glucose uptake: effects of intracellular Ca(2+), cAMP and glucosamine
Jinshyun R Wu-Wong
Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL, U S A
Clin Sci (Lond) 103:418S-423S. 2002
..These results suggest that ET-1-induced glucose uptake is independent of its effects on modulating intracellular Ca(2+) and cAMP levels, but is likely linked to the hexosamine biosynthetic pathway...
- Spontaneous versus reinforced olfactory discriminations
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
J Neurosci 22:6842-5. 2002
..At the same time, the major differences in glomerular responses appear to serve as the normal basis for spontaneous odor discrimination...
- Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Brain Res 923:58-70. 2001
..TRCs that exhibit Type II responses could also be activated by quinine (which increased Ca(2+)(I)) thus suggesting a mechanism by which the addition of acid may be suppressive to other chemical stimuli...
- Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex
Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, 09124 Cagliari, Italy
J Neurosci 22:4709-19. 2002
..These observations indicate that DA responsiveness is an integrated function of the motivational valence and novelty of stimuli in the NAc shell and an expression of generic motivational value in the NAc core and PFCX...
- Optical imaging of odor preference memory in the rat olfactory bulb
Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Saitama 351 0198, Japan
J Neurophysiol 87:3156-9. 2002
..These observations demonstrate that odor preference memory can be read-out by optical imaging techniques...
- The control of water and sodium chloride intake by postingestional and orosensory stimulation in water-deprived rats
John D Davis
Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University, Edward W Bourne Laboratory, New York Presbyterian Hospital, 21 Bloomingdale Road, White Plains, NY 10605, USA
Physiol Behav 75:7-14. 2002
..Postingestional stimulation, however, played an indirect role by serving as the unconditioned stimulus for the conditioned orosensory control...
- Mechanisms of gastric mucus secretion from cultured rat gastric epithelial cells induced by carbachol, cholecystokinin octapeptide, secretin, and prostaglandin E2
Faculty of Pharmaceutical Sciences and Life Science Research Center, Josai University, Sakado, Saitama, Japan
Biol Pharm Bull 25:14-8. 2002
..These results suggest that the [Ca2+]i plays an important role in mucus secretion through cAMP accumulation...
- Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Neuroscience 111:435-41. 2002
..We suggest that the ratio between free sulfhydryl groups and disulfide bonds of the cysteine residues of VR1 pre-sets sensitivity of primary nociceptors to algogens and may represent a new target for treating some pain states in humans...