chemical stimulation

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Top Publications

  1. pmc Matching native electrical stimulation by graded chemical stimulation in isolated mouse adrenal chromaffin cells
    Tiberiu Fulop
    Department of Physiology and Biophysics, School of Medicine, 2109 Adelbert Road, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    J Neurosci Methods 166:195-202. 2007
  2. ncbi Single olfactory sensory neurons simultaneously integrate the components of an odour mixture
    Patricia Duchamp-Viret
    Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS, UMR 5020, Universite Claude Bernard, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Eur J Neurosci 18:2690-6. 2003
  3. ncbi Representation of odor habituation and timing in the hippocampus
    Sachin S Deshmukh
    National Centre for Biological Sciences, Gandhi Krishi Vignana Kendra Campus, Bangalore 560065, India
    J Neurosci 23:1903-15. 2003
  4. ncbi Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation
    I J Lever
    Neuroscience Research Center and Department of Pharmacology, Guy's, King's, and St. Thomas' School of Biomedical Sciences, King's College London, London SE1 1UL, United Kingdom
    J Neurosci 21:4469-77. 2001
  5. ncbi Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists
    L S Sorkin
    Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
    Pain 77:181-90. 1998
  6. pmc Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip
    Matthias Meier
    Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 E 57th Street, Chicago, IL, USA
    Lab Chip 10:2147-53. 2010
  7. ncbi Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex--an experimental model for vascular dysfunctions in cluster headache
    R Gottselig
    Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
    Cephalalgia 24:206-14. 2004
  8. pmc Metallic taste from electrical and chemical stimulation
    Harry T Lawless
    Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA
    Chem Senses 30:185-94. 2005
  9. ncbi Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa
    G Kobal
    Institute of Pharmacology and Toxicology, University Erlangen Nurnberg, F R G
    Electroencephalogr Clin Neurophysiol 71:241-50. 1988
  10. pmc Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice
    Vicktoria Danilova
    Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
    BMC Neurosci 4:5. 2003

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Detail Information

Publications216 found, 100 shown here

  1. pmc Matching native electrical stimulation by graded chemical stimulation in isolated mouse adrenal chromaffin cells
    Tiberiu Fulop
    Department of Physiology and Biophysics, School of Medicine, 2109 Adelbert Road, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    J Neurosci Methods 166:195-202. 2007
    ..We address this limitation in the current study. We describe a bulk chemical stimulation paradigm calibrated to match defined electrical activity...
  2. ncbi Single olfactory sensory neurons simultaneously integrate the components of an odour mixture
    Patricia Duchamp-Viret
    Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS, UMR 5020, Universite Claude Bernard, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Eur J Neurosci 18:2690-6. 2003
    ....
  3. ncbi Representation of odor habituation and timing in the hippocampus
    Sachin S Deshmukh
    National Centre for Biological Sciences, Gandhi Krishi Vignana Kendra Campus, Bangalore 560065, India
    J Neurosci 23:1903-15. 2003
    ..This may act as a neuronal substrate for habituation and for complex tasks such as odor-guided navigation...
  4. ncbi Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation
    I J Lever
    Neuroscience Research Center and Department of Pharmacology, Guy's, King's, and St. Thomas' School of Biomedical Sciences, King's College London, London SE1 1UL, United Kingdom
    J Neurosci 21:4469-77. 2001
    ..Here we show that BDNF is released in the rat isolated dorsal horn after chemical stimulation by capsaicin or electrical stimulation of dorsal roots...
  5. ncbi Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists
    L S Sorkin
    Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
    Pain 77:181-90. 1998
    ..Removal of each influence may model a different component of neuropathic pain...
  6. pmc Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip
    Matthias Meier
    Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 E 57th Street, Chicago, IL, USA
    Lab Chip 10:2147-53. 2010
    ....
  7. ncbi Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex--an experimental model for vascular dysfunctions in cluster headache
    R Gottselig
    Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
    Cephalalgia 24:206-14. 2004
    ..was developed in the rat to measure changes in lacrimation and intracranial blood flow following noxious chemical stimulation of facial mucosa...
  8. pmc Metallic taste from electrical and chemical stimulation
    Harry T Lawless
    Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA
    Chem Senses 30:185-94. 2005
    ..5-3 V) was not affected by nasal occlusion. This difference suggests two distinct mechanisms for evocation of metallic taste reports, one dependent upon retronasal smell and a second mediated by oral chemoreceptors...
  9. ncbi Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa
    G Kobal
    Institute of Pharmacology and Toxicology, University Erlangen Nurnberg, F R G
    Electroencephalogr Clin Neurophysiol 71:241-50. 1988
    ..Responses to the mixture of carbon dioxide and vanillin appeared significantly earlier (50-150 msec) than responses to either substance alone...
  10. pmc Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice
    Vicktoria Danilova
    Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
    BMC Neurosci 4:5. 2003
    ....
  11. pmc Responses of nerve fibres of the rat saphenous nerve neuroma to mechanical and chemical stimulation: an in vitro study
    L Rivera
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, San Juan de Alicante, 03550 Alicante, Spain
    J Physiol 527:305-13. 2000
    ..They became mechanically sensitive after chemical stimulation. These findings show that neuroma nerve endings in the rat saphenous nerve neuroma in vitro are ..
  12. ncbi Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal
    G C D Eichenberger
    Faculdade de Medicina de Ribeirao Preto, Departamento de Farmacologia, Universidade de Sao Paulo, Lab de Neuroanatomia e Neuropsicobiologia, Avenida dos Bandeirantes 3900, 14049 900, Ribeirao Preto, Brazil
    Neuropharmacology 42:48-59. 2002
    ..antagonists on the aversive responses elicited by electrical (at the freezing and escape thresholds) or chemical stimulation (crossings, rearings, turnings and jumps, induced by microinjections of bicuculline) of the midbrain tectum ..
  13. ncbi A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function
    John I Glendinning
    Department of Biological Science, Barnard College, Columbia University, New York, NY 10027, USA
    Chem Senses 27:461-74. 2002
    ..This screen represents a significant improvement over the common two-bottle preference test because it assesses taste function more specifically and in a fraction of the time...
  14. pmc Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors
    Xavier Grosmaitre
    Department of Neuroscience, University of Pennsylvania School of Medicine, 215 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Nat Neurosci 10:348-54. 2007
    ....
  15. pmc The rostral ventrolateral medulla mediates the sympathoactivation produced by chemical stimulation of the rat nasal mucosa
    P F McCulloch
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Physiol 516:471-84. 1999
    1. We sought to outline the brainstem circuit responsible for the increase in sympathetic tone caused by chemical stimulation of the nasal passages with ammonia vapour...
  16. pmc Individual mouse taste cells respond to multiple chemical stimuli
    Alejandro Caicedo
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Physiol 544:501-9. 2002
    ..Thus, there appears to be no strict and separate detection of taste qualities by distinct subpopulations of taste cells in peripheral gustatory sensory organs in mice...
  17. pmc Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists
    Beatriz Fioravanti
    Departments of Pharmacology and Anesthesiology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 28:11593-602. 2008
    ..These studies propose possible therapeutic exploitation of a novel mechanism providing pain relief by CB(1) inverse agonists...
  18. ncbi Neural representation of bitter taste in the nucleus of the solitary tract
    Christian H Lemon
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, 38163, USA
    J Neurophysiol 94:3719-29. 2005
    ..Thus central neurons most responsive to bitter substances receive significant input from receptors that mediate other tastes, indicating that bitter stimuli are not represented by activity in specifically tuned neurons...
  19. ncbi Taste-specific neuronal ensembles in the gustatory cortex of awake rats
    Donald B Katz
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 22:1850-7. 2002
    ..These data suggest that taste-specific GC assemblies may transiently form and coevolve on a behaviorally appropriate timescale, contributing to rats' ability to discriminate tastants...
  20. ncbi Spinal substance P immunoreactivity is enhanced by acute chemical stimulation of the rat prostate
    Manabu Ishigooka
    Department of Urology, Yamagata University School of Medicine, Yamagata, Japan
    Urology 59:139-44. 2002
    ..SP is considered a mediator of nociception in the spinal cord. Immunoreactivity of SP is enhanced after acute chemical stimulation of somata.
  21. ncbi The contribution of taste bud populations to bitter avoidance in mouse strains differentially sensitive to sucrose octa-acetate and quinine
    Steven J St John
    Department of Psychology, Reed College, Portland, OR 97202, USA
    Chem Senses 29:775-87. 2004
    ..These findings are discussed with regard to the distribution in the oral cavity of putative taste receptors for quinine and SOA and the peripheral organization of bitter taste...
  22. ncbi Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes
    Euan A Ashley
    University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    Circulation 105:3011-6. 2002
    ..Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction...
  23. ncbi Modulation of human swallowing behaviour by thermal and chemical stimulation in health and after brain injury
    S Hamdy
    Department of GI Sciences, Hope Hospital, Salford, UK
    Neurogastroenterol Motil 15:69-77. 2003
    Few data support thermal or chemical stimulation as therapy for neurogenic dysphagia...
  24. ncbi Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice
    Nixon M Abraham
    WIN Group of Olfactory Dynamics, Heidelberger Akademie der Wissenschaften and Max Planck Institut für medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuron 44:865-76. 2004
    ..The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed...
  25. ncbi Speed and accuracy of olfactory discrimination in the rat
    Naoshige Uchida
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:1224-9. 2003
    ....
  26. ncbi Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes
    C Bagni
    Dipartimento di Biologia, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 20:RC76. 2000
    ..Dendritic mRNA recruitment onto polysomes in response to synaptic stimulation might represent one of the mechanisms underlying the processes of learning and memory...
  27. ncbi Dynamic and multimodal responses of gustatory cortical neurons in awake rats
    D B Katz
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 21:4478-89. 2001
    ....
  28. ncbi Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
    ....
  29. ncbi Distribution of gustatory sensitivities in rat taste cells: whole-cell responses to apical chemical stimulation
    T A Gilbertson
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808-4124, USA
    J Neurosci 21:4931-41. 2001
    ..4%) to three, and 8 (13.6%) to all of the basic stimuli. Cells with both inward (Na(+)) and outward (K(+)) voltage-activated currents were significantly more broadly tuned to gustatory stimuli than those with only inward currents...
  30. ncbi Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat
    Robert J Hayes
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Psychopharmacology (Berl) 168:75-83. 2003
    ..In animals, the BLC is necessary for cocaine-seeking behavior elicited by cocaine-associated cues. It has not been determined whether BLC activation is sufficient to reinstate cocaine seeking...
  31. ncbi Effects of osmolarity on taste receptor cell size and function
    V Lyall
    Department of Physiology, Virginia Commonwealth University, Richmond 23298, Virginia, USA
    Am J Physiol 277:C800-13. 1999
    ..These data suggest that the osmolyte-induced increase in the CT response to NaCl involves a sustained decrease in TRC volume and the activation of amiloride-sensitive apical Na(+) channels...
  32. ncbi Facilitation of voluntary swallowing by chemical stimulation of the posterior tongue and pharyngeal region in humans
    Rika Yahagi
    Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University, Morioka 020 8505, Japan
    Neurosci Lett 448:139-42. 2008
    ....
  33. pmc Mechanism of heart rate responses elicited by chemical stimulation of the hypothalamic paraventricular nucleus in the rat
    Tetsuya Kawabe
    Department of Neurological Surgery, MSB H 586, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Brain Res 1248:115-26. 2009
    ..Experiments were done in urethane-anesthetized, barodenervated, adult, male Wistar rats. Chemical stimulation of the PVN by unilateral microinjections of N-methyl-d-aspartic acid (NMDA) elicited increases in HR which ..
  34. ncbi Encoding and decoding of overlapping odor sequences
    Bede M Broome
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    Neuron 51:467-82. 2006
    ..Thus, PN population dynamics are history dependent, and responses of individual KCs are consistent with piecewise temporal decoding of PN output over large sections of the PN population...
  35. ncbi Encoding social signals in the mouse main olfactory bulb
    Da Yu Lin
    HHMI and Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 434:470-7. 2005
    ..We conclude that mitral cells represent natural odorant stimuli by acting as selective feature detectors, and that their activation is largely independent of the presence of other components in the olfactory stimulus...
  36. ncbi State-dependent modulation of time-varying gustatory responses
    Alfredo Fontanini
    Volen National Center for Complex Systems, MS 013, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    J Neurophysiol 96:3183-93. 2006
    ..These data suggest that neural state changes can change the content of neural codes...
  37. ncbi Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli
    Alejandro Caicedo
    Department of Physiology and Biophysics and Program in Neuroscience, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 23:9947-52. 2003
    ..The reduced behavioral sensitivity to bitter stimuli in alpha-gustducin knock-out mice thus appears to be the consequence of a reduced number of bitter-activated taste cells, as well as reduced sensitivity...
  38. ncbi Analysis of training-induced changes in ethyl acetate odor maps using a new computational tool to map the glomerular layer of the olfactory bulb
    Ernesto Salcedo
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, Mail Stop 8108 PO Box 6511, Aurora, CO 80045, USA
    Chem Senses 30:615-26. 2005
    ..The software generates odor maps (density plots) based on glomerular activity, density, or area. We find that training up-regulates the number of glomeruli that become c-fos positive after stimulation with ethyl acetate...
  39. ncbi Modulation of parabrachial taste neurons by electrical and chemical stimulation of the lateral hypothalamus and amygdala
    Cheng Shu Li
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Science Center, 855 Monroe Ave, Suite 515, Memphis, TN 38163, USA
    J Neurophysiol 93:1183-96. 2005
    ..This neural substrate is likely involved in the modulation of taste activity by physiological and experiential factors...
  40. ncbi Cardiovascular responses elicited by chemical stimulation of the rostral ventrolateral medulla in conscious, unrestrained rats
    H Bachelard
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham, U K
    J Auton Nerv Syst 31:185-90. 1990
    ....
  41. ncbi Functional magnetic resonance imaging in rats subjected to intense electrical and noxious chemical stimulation of the forepaw
    U I Tuor
    Biosystems, Institute for Biodiagnostics, National Research Council, 435 Ellice Avenue, Manitoba, R3B 1Y6, Winnipeg, Canada
    Pain 87:315-24. 2000
    ..fMRI combined with appropriate exploratory data analysis tools could provide an effective new tool with which to study novel analgesics and their effects on the CNS processing of pain in animal models...
  42. ncbi Cardiovascular responses to chemical stimulation of the lateral tegmental field and adjacent medullary reticular formation in the rat
    V Marchenko
    Department of Neurosurgery, MSB H 586, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103 2757, USA
    Brain Res 977:247-60. 2003
    Relatively few studies have been done to characterize cardiovascular responses to the chemical stimulation of sites located in the medullary lateral tegmental field (LTF) and most of them have been carried out in anesthetized animals...
  43. ncbi GABAA-Receptor blockade reverses the injury-induced sensitization of nociceptor-specific (NS) neurons in the spinal dorsal horn of the rat
    Esther Garcia-Nicas
    Department of Physiology, University of Alcala, Madrid, Spain
    J Neurophysiol 96:661-70. 2006
    ..This provides evidence for a mechanism in which an enhanced GABAergic transmission can lead to hyperexcitability and sensitization of NS neurons in the dorsal horn...
  44. ncbi Effect of amiloride on gustatory responses in the ventroposteromedial nucleus of the thalamus in rats
    Justus V Verhagen
    College of Sciences, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 1010, USA
    J Neurophysiol 93:157-66. 2005
    ..Thus membership in a neuronal group retains functional significance based on a receptor event 4 synapses away...
  45. ncbi Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli
    Laura C Geran
    Section of Oral Biology, College of Dentistry, Ohio State University, 305 W 12th Ave Postle Hall, Columbus, OH 43210, USA
    J Neurophysiol 96:2513-27. 2006
    ..These results indicate heterogeneity for the processing of ionic and nonionic bitter tastants, which is dependent on receptive field. Further, they suggest that neurons selective for bitter substances could contribute to taste coding...
  46. ncbi Chorda tympani responses in two inbred strains of mice with different taste preferences
    M E Frank
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Physiol Behav 67:287-97. 1999
    ..Nonetheless, genes involved in the structuring of taste receptors and/or the chordae tympani, which transduce taste stimuli having diverse perceptual qualities, differ for the two mouse strains...
  47. ncbi Dynamic coding of taste stimuli in the brainstem: effects of brief pulses of taste stimuli on subsequent taste responses
    Patricia M Di Lorenzo
    Department of Psychology, State University of New York at Binghamton, Binghamton, New York 13902, USA
    J Neurosci 23:8893-902. 2003
    ..Dynamic tuning may be the result of inhibitory interactions within the NTS; cells that show dynamic tuning may have a unique function in taste coding...
  48. ncbi Hippocampal dopamine receptors modulate cFos expression in the rat nucleus accumbens evoked by chemical stimulation of the ventral hippocampus
    Teodoro Zornoza
    Department de Farmàcia i Tecnología Farmacèutica, Facultat de Farmacia, Universitat de Valencia, Avda Vicente Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Neuropharmacology 49:1067-76. 2005
    ..In contrast, raclopride had no significant effect. Our present results show that the NMDA receptor mediated effects in the VH require D1 receptors and suggest that DA in VH strongly modulates the excitatory outputs from this brain area...
  49. ncbi Three-dimensional estimation of the distribution and size of putative functional units in rat gustatory cortex as assessed from the inter-neuronal distance between two neurons with correlative activity
    T Yokota
    Department of Physiology, School of Dental Medicine, Aichi Gakuin University, Nagoya, Japan
    Brain Res Bull 54:575-84. 2001
    ..In conclusion we point out that nearby neurons are prone to CA, if (1) their best tastes are identical, (2) their taste profiles are similar, and (3) the temporal patterns of taste response resemble each other...
  50. ncbi Hippocampal dopamine receptors modulate the motor activation and the increase in dopamine levels in the rat nucleus accumbens evoked by chemical stimulation of the ventral hippocampus
    Teodoro Zornoza
    Department de Farmàcia i Tecnología Farmacèutica, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
    Neuropsychopharmacology 30:843-52. 2005
    A number of studies have shown that chemical stimulation (using N-methyl-D-aspartate (NMDA) infusions) or electrical stimulation of the ventral hippocampus (VH) elicits locomotor activation and sustained increases in nucleus accumbens (..
  51. pmc Interactions between salt and acid stimuli: a lesson in gustation from simultaneous epithelial and neural recordings
    S A Simon
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    J Gen Physiol 120:787-91. 2002
  52. ncbi Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons: role of cAMP/PKA signaling pathway
    Qihai Gu
    Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurophysiol 89:1985-93. 2003
    The effect of prostaglandin E(2) (PGE(2)) on chemical stimulation-evoked calcium (Ca(2+)) transient was investigated in isolated vagal sensory neurons of the rat using fura-2-based ratiometric Ca(2+) imaging...
  53. ncbi Evidence for a role of basal ganglia in the regulation of rapid eye movement sleep by electrical and chemical stimulation for the pedunculopontine tegmental nucleus and the substantia nigra pars reticulata in decerebrate cats
    K Takakusaki
    Department of Physiology, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa 078 8510, Japan
    Neuroscience 124:207-20. 2004
    ..An excessive GABAergic output from the basal ganglia to the PPN in parkinsonian patients may induce sleep disturbances, including a reduction of REM sleep periods and REM sleep behavioral disorders (REM without atonia)...
  54. pmc Coordinate synaptic mechanisms contributing to olfactory cortical adaptation
    Aaron R Best
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 24:652-60. 2004
    ..Importantly, in line with the in vitro findings, both adaptation of odor responses in the beta (15-35 Hz) spectral range and the associated synaptic depression can also be blocked by intracortical infusion of CPPG in vivo...
  55. ncbi Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL
    Toshiyuki Watanabe
    Oral Cellular and Molecular Biology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Fukuoka 812 8582, Japan
    J Endocrinol 180:193-201. 2004
    ....
  56. ncbi The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli
    J Amiel Rosenkranz
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 23:11054-64. 2003
    ..This may be attributable to the loss of PFC-imposed inhibition of the emotional response to a stimulus but may also include the formation or diminished extinction of inappropriate associations...
  57. pmc Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain
    A Florence Keller
    Unite de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, QC G1J 2G3, Canada
    Mol Pain 3:27. 2007
    ..But, a central unresolved question is whether this disinhibition can transform the activity and responses of spinal nociceptive output neurons to account for the symptoms of neuropathic pain...
  58. ncbi Long-term recordings from afferent taste fibers
    Yuichi Shimatani
    Department of Physiology, School of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Physiol Behav 80:309-15. 2003
    ..These changes in response characteristics were hypothesized to result from changes in the taste receptor cells as the receptor cells turnover in the taste buds...
  59. ncbi Early odor preference learning in the rat: bidirectional effects of cAMP response element-binding protein (CREB) and mutant CREB support a causal role for phosphorylated CREB
    Qi Yuan
    Division of Basic Medical Sciences, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 23:4760-5. 2003
    ..They support evidence that CREB overexpression can be deleterious and suggest the hypothesis of an optimal pCREB window for learning...
  60. ncbi [The dentate gyrus neurogenesis: a common therapeutic target for Alzheimer disease and senile depression?]
    Yoshitaka Tatebayashi
    Lab for Alzheimer s Disease, Brain Science Institute, RIKEN
    Seishin Shinkeigaku Zasshi 105:398-404. 2003
    ..Pseudodementia might also involve suppressed neurogenesis but differ form AD since the neurodegenerative process in AD may be irreversible...
  61. ncbi Dietary sodium deprivation reduces gustatory neural responses of the parabrachial nucleus in rats
    Tao Huang
    Department of Physiology and Pathophysiology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi 710061, People s Republic of China
    Neurosci Lett 432:170-3. 2008
    ..These findings suggest that dietary sodium deprivation might modulate sodium intake via increasing aversive threshold for salt rather enhancing salt discrimination...
  62. ncbi Blockade of NMDA receptors in prelimbic cortex induces an enduring amnesia for odor-reward associative learning
    Sophie Tronel
    Neuromodulation and Memory Processes, Unite Mixte de Recherche 7102, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 75005 Paris, France
    J Neurosci 23:5472-6. 2003
    ..These results underlie the role of NMDA receptors in the early stage of consolidation of a simple odor-reward associative memory and confirm the role of the PLC in the consolidation of long-term memory...
  63. ncbi Mucosal activity patterns as a basis for olfactory discrimination: comparing behavior and optical recordings
    P F Kent
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Brain Res 981:1-11. 2003
    ..9, P=nil). These results give additional credence to the concept that the odorant-induced mucosal activity patterns may serve as the substrate for the perception of odorant quality...
  64. pmc Activation of purinergic receptor subtypes modulates odor sensitivity
    Colleen C Hegg
    Department of Physiology, University of Utah, Salt Lake City, Utah 84108 1297, USA
    J Neurosci 23:8291-301. 2003
    ..Peripheral ATP-mediated odor suppression is a novel mechanism for reduced olfactory sensitivity during exposure to olfactotoxins and may be a novel neuroprotective mechanism...
  65. ncbi Kainate-induced excitation and sensitization of nociceptors in normal and inflamed rat glabrous skin
    J Du
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neuroscience 137:999-1013. 2006
    ..The data indicate that peripheral kainate receptors not only play an important role in normal nociception but also contribute to mechanical sensitivity and heat sensitization accompanying inflammatory pain...
  66. ncbi Rat olfactory bulb mitral cells receive sparse glomerular inputs
    Antoniu L Fantana
    Molecular and Cellular Biology Department and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 59:802-14. 2008
    ..We conclude that mitral cells do not have center-surround receptive fields. Instead, each mitral cell performs a specific computation combining a small and diverse set of glomerular inputs...
  67. ncbi Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor
    L Wu
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Gene Ther 10:1712-20. 2003
    ..These results demonstrate a new approach to engineer physiologically regulated insulin secretion by non-beta cells...
  68. pmc Odor representations in the rat olfactory bulb change smoothly with morphing stimuli
    Adil G Khan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India
    Neuron 57:571-85. 2008
    ..We suggest that our olfactory coding model captures many aspects of single and mixed odor representation in M/T cells...
  69. ncbi "Green odor" inhalation reduces the skin-barrier disruption induced by chronic restraint stress in rats: physiological and histological examinations
    Mika Fukada
    Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine, Yonago, Tottori 683, Japan
    Chem Senses 32:633-9. 2007
    ....
  70. ncbi Effects of electrical stimulation of the glossopharyngeal nerve on cells in the nucleus of the solitary tract of the rat
    Robert M Hallock
    Department of Psychology, Box 6000, State University of New York at Binghamton, Binghamton, New York 13902 6000, USA
    Brain Res 1113:163-73. 2006
    ..These differences may reflect the respective functional specializations of the GP and CT nerves...
  71. ncbi Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)
    A B Dongmo
    Laboratoire de Biologie des Organismes animaux, Faculte des Sciences, Université de Douala, BP 24157 Douala, Cameroun
    J Ethnopharmacol 98:201-6. 2005
    ..Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities...
  72. ncbi Organization of electrically and chemically evoked defensive behaviors within the deeper collicular layers as compared to the periaqueductal gray matter of the rat
    A S Bittencourt
    Departamento de Ciencias Fisiologicas, Centro Biomedico, Edifício do Programa de Pós Graduação em Ciências Fisiológicas, Universidade Federal do Espirito Santo, Av Marechal Campos 1468 Maruípe, 29043 125 Vitória, ES, Brazil
    Neuroscience 133:873-92. 2005
    ..b>Chemical stimulation employed a slow microinfusion of N-methyl-d-aspartic acid (NMDA, 0-2.3 nmol, 0.5 nmol/min)...
  73. ncbi Nicotine increases microdialysate brain amino acid concentrations and induces conditioned place preference
    Vladimir A Kashkin
    Valdman Institute of Pharmacology, Pavlov Medical University, St Petersburg, 197089, Russia
    Eur Neuropsychopharmacol 15:625-32. 2005
    ..The same doses of nicotine were able to elicit a reinforcing effect in a CPP paradigm which was probably associated with the increased brain levels of excitatory acids triggering additional dopamine release in the mesolimbic system...
  74. ncbi L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells
    Stephanie M Busque
    Dept of Surgery, Yale University, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 289:G664-9. 2005
    ..These data support the conclusion that amino acids, in conjunction with a physiological Ca(o)(2+) concentration, can induce acid secretion independent of hormonal stimulation via allosteric activation of the stomach CaSR...
  75. ncbi Growth-stimulating effect of kallikrein on rat neural stem cells--II. Immunocytochemical analysis and specificity of the enzyme for neural stem cells
    Kazuyuki Kizuki
    Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science, Yamaguchi, Japan
    Yakugaku Zasshi 127:919-22. 2007
    ..i.e., kallikrein administered into the body stimulates neural stem cell proliferation and new neurons may be generated from them...
  76. ncbi Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle-nerve preparations in vitro after eccentric contraction
    Toru Taguchi
    Department of Neural Regulation, Division of Regulation of Organ Function, Research Institute of Environmental Medicine, Nagoya, Japan
    J Neurophysiol 94:2822-31. 2005
    ..These results suggest that augmentation of the mechanical response in muscle thin-fiber sensory receptors might be related to the muscle tenderness in DOMS after ECC...
  77. ncbi Regulation of activin A and inhibin B secretion by inflammatory mediators in adult rat Sertoli cell cultures
    Y Okuma
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    J Endocrinol 187:125-34. 2005
    ..Interference with the complex interactions between these cytokines and hormones may contribute to the disruption of reproductive function that can accompany infection and illness in men...
  78. ncbi Species differences in the gut stimulatory effects of radish seeds
    Muhammad Nabeel Ghayur
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Sind, Pakistan
    J Pharm Pharmacol 57:1493-501. 2005
    ....
  79. ncbi Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways
    Michel F Otuki
    Department of Pharmacology, Centre of Biological Sciences, Federal University of Santa Catarina, Campus Universitario Trindade, Bloco D CCB, Cx Postal 476, CEP 88049 900, Florianopolis, SC, Brazil
    J Pharmacol Exp Ther 313:310-8. 2005
    ..The mechanisms involved in their action are not completely understood but seem to involve the inhibition of protein kinase A- and protein kinase C-sensitive pathways...
  80. ncbi Neurons in superficial trigeminal subnucleus caudalis responsive to oral cooling, menthol, and other irritant stimuli
    Karen L Zanotto
    Section of Neurobiology, Physiology and Behavior, University of California Davis, 1 Shields Ave, Davis, CA 95616, USA
    J Neurophysiol 97:966-78. 2007
    ..The convergent nature of these units suggests a general role in signaling noxious stimuli...
  81. ncbi Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system
    Weihong Lin
    Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 24:3703-10. 2004
    ..These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors...
  82. ncbi Chemical factors determine olfactory system beta oscillations in waking rats
    Catherine A Lowry
    Committee on Neurobiology, Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA
    J Neurophysiol 98:394-404. 2007
    ..Theta band coherence analysis shows that coupling strength between the olfactory bulb and piriform cortex increases linearly with vapor phase concentration, which may facilitate beta oscillations above a threshold...
  83. ncbi Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFbeta1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells
    Yun Ju Chen
    Institute of Physiology, School of Medicine, National Yang Ming University, 155 Linong Street, Section 2, Taipei 112, Taiwan, Republic of China
    J Endocrinol 192:405-19. 2007
    ..Furthermore, we demonstrate for the first time that TGFbeta1 acts in a rapamycin-hypersensitive and mTORC1-independent manner in augmenting FSH-stimulated steroidogenesis in rat granulosa cells...
  84. ncbi Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam
    Iain S McGregor
    School of Psychology, University of Sydney, Sydney, New South Wales 2006, Australia
    J Neurosci 24:4134-44. 2004
    ..These findings also suggest the intriguing hypothesis that cat odor is processed by rats as a "pheromone-like" stimulus...
  85. ncbi Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons
    Jennifer Spehr
    Lehrstuhl fuer Zellphysiologie, Ruhr Universitaet Bochum, Universitaetsstr 150, 44780 Bochum, Germany
    Eur J Neurosci 19:2497-510. 2004
    ..Therefore, we assume a functional role for the newly identified subpopulation in chemodetection of certain trigeminal stimuli...
  86. ncbi Olfaction in olfactory bulbectomized rats
    Burton Slotnick
    Department of Psychology, University of South Florida, Tampa, Florida 33549, USA
    J Neurosci 24:9195-200. 2004
    ..Our results provide strong support for the contention that, in the absence of the olfactory bulbs, olfactory connections to novel forebrain sites can support both odor detection and odor discrimination...
  87. ncbi Central neuropeptide B administration activates stress hormone secretion and stimulates feeding in male rats
    W K Samson
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    J Neuroendocrinol 16:842-9. 2004
    ....
  88. ncbi Stimulation of the parapyramidal region of the neonatal rat brain stem produces locomotor-like activity involving spinal 5-HT7 and 5-HT2A receptors
    Jun Liu
    Department of Physiology, Spinal Cord Research Centre, University of Manitoba Winnipeg, Winnipeg, Canada
    J Neurophysiol 94:1392-404. 2005
    ..region (PPR) of the mid-medulla produced locomotor-like activity as a result of either electrical or chemical stimulation, and PPR-evoked locomotor-like activity was blocked by antagonists to 5-HT2A and 5-HT7 receptors located on ..
  89. pmc Responses of the rat olfactory epithelium to retronasal air flow
    John W Scott
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurophysiol 97:1941-50. 2007
    ..The results also strongly support the importance of odorant sorption in normal olfactory processes...
  90. ncbi Differential covariation in taste responsiveness to bitter stimuli in rats
    Susan M Brasser
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Chem Senses 30:793-9. 2005
    ..More generally, these data reinforce the notion that bitter taste processing is not a homogeneous event...
  91. ncbi Injury-induced functional plasticity in the peripheral gustatory system
    Susan J Hendricks
    Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:8607-13. 2002
    ....
  92. ncbi [Effect of nitric oxide on force-frequency relations in experimental hyperfunction and hypertrophy in the heart muscle]
    T S Lahodych
    National Medical University, Kiev
    Fiziol Zh 47:3-10. 2001
    ..We conclude that the paradoxical response of hypertrophy of hearts is connected to infringements of redistribution of ions Ca between extracellular medium and intracellular stores in a systole and diastole...
  93. ncbi Corticotrophin-releasing hormone inhibits insulin-like growth factor-I release from primary cultures of rat granulosa cells
    A E Calogero
    Section of Endocrinology, Andrology and Internal Medicine, Department of Biomedical Sciences, University of Catania, Ospedale Garibaldi, Piazza S Maria de Gesú, 95123 Catania, Italy
    J Endocrinol 174:493-8. 2002
    ..In conclusion, CRH suppressed the release of oestrogen and IGF-I, but not of IGFBP-3. Thus, the inhibitory effects of CRH on oestrogen release could be mediated, partly, by a suppression of the autocrine/paracrine action of IGF-I...
  94. ncbi Endothelin-stimulated glucose uptake: effects of intracellular Ca(2+), cAMP and glucosamine
    Jinshyun R Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL, U S A
    Clin Sci (Lond) 103:418S-423S. 2002
    ..These results suggest that ET-1-induced glucose uptake is independent of its effects on modulating intracellular Ca(2+) and cAMP levels, but is likely linked to the hexosamine biosynthetic pathway...
  95. ncbi Spontaneous versus reinforced olfactory discriminations
    Christiane Linster
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 22:6842-5. 2002
    ..At the same time, the major differences in glomerular responses appear to serve as the normal basis for spontaneous odor discrimination...
  96. ncbi Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae
    L Liu
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 923:58-70. 2001
    ..TRCs that exhibit Type II responses could also be activated by quinine (which increased Ca(2+)(I)) thus suggesting a mechanism by which the addition of acid may be suppressive to other chemical stimuli...
  97. ncbi Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex
    Valentina Bassareo
    Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, 09124 Cagliari, Italy
    J Neurosci 22:4709-19. 2002
    ..These observations indicate that DA responsiveness is an integrated function of the motivational valence and novelty of stimuli in the NAc shell and an expression of generic motivational value in the NAc core and PFCX...
  98. ncbi Optical imaging of odor preference memory in the rat olfactory bulb
    Qi Yuan
    Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Saitama 351 0198, Japan
    J Neurophysiol 87:3156-9. 2002
    ..These observations demonstrate that odor preference memory can be read-out by optical imaging techniques...
  99. ncbi The control of water and sodium chloride intake by postingestional and orosensory stimulation in water-deprived rats
    John D Davis
    Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University, Edward W Bourne Laboratory, New York Presbyterian Hospital, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Physiol Behav 75:7-14. 2002
    ..Postingestional stimulation, however, played an indirect role by serving as the unconditioned stimulus for the conditioned orosensory control...
  100. ncbi Mechanisms of gastric mucus secretion from cultured rat gastric epithelial cells induced by carbachol, cholecystokinin octapeptide, secretin, and prostaglandin E2
    Satoru Tani
    Faculty of Pharmaceutical Sciences and Life Science Research Center, Josai University, Sakado, Saitama, Japan
    Biol Pharm Bull 25:14-8. 2002
    ..These results suggest that the [Ca2+]i plays an important role in mucus secretion through cAMP accumulation...
  101. ncbi Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1
    L Vyklicky
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Neuroscience 111:435-41. 2002
    ..We suggest that the ratio between free sulfhydryl groups and disulfide bonds of the cysteine residues of VR1 pre-sets sensitivity of primary nociceptors to algogens and may represent a new target for treating some pain states in humans...

Research Grants62

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Ecstasy and the Dorsomedial Hypothalamus
    Daniel E Rusyniak; Fiscal Year: 2010
    ..Many of the physiologic effects of MDMA can be replicated by chemical stimulation of neurons in the area of the DMH...
  3. Tissue Engineering Strategies: Effects on Valvular Interstitial Cell Metabolism
    KATHRYN JANE GRANDE-ALLEN; Fiscal Year: 2012
    ..is influenced by the environment of the cell, meaning its pericellular matrix and level of mechanical or chemical stimulation. These issues are very important given the use of exogenous stimuli in the development of tissue engineered ..
  4. Neutrophil Decision Making in Confined Environments in Health and Disease
    Daniel Irimia; Fiscal Year: 2013
    ..While current methods for studying neutrophils relay exclusively on chemical stimulation of the cells, we have recently shown that the mechanical confinement of the neutrophils in small channels ..
  5. Metabolite effects on Group III and IV afferents
    MARC PETER KAUFMAN; Fiscal Year: 2013
    ..Dynamic exercise will be induced in decerebrated unanesthetized cats by electrical and possibly chemical stimulation of the mesencephalic or subthalamic locomotor regions...
  6. Hypothalamic Control of IOP, ICP, and the Translaminar Pressure Gradient
    BRIAN CHRISTOPHER SAMUELS; Fiscal Year: 2013
    ..The PI recently identified that chemical stimulation of dorsomedial and perifornical hypothalamic neurons with bicuculline methoidide (BMI;30pmol/75nl) evokes ..
  7. Rodent Behavioral Model of Ongoing Headache Pain
    ANDREW MARK STRASSMAN; Fiscal Year: 2013
    ..breakthrough for the study of headache: a new observation of a change in "spontaneous" behavior following chemical stimulation of the dura in rats...
  8. Bio-ionic Neural Interfaces
    LUKE SATISH KUMAR THEOGARAJAN; Fiscal Year: 2010
    ..The required concentration of ions for chemical stimulation is only 2-3X over the background concentration of 5mM...
  9. MODULATORY ROLE OF GABA AND 5HT RECEPTORS IN MIGRAINE
    F Cutrer; Fiscal Year: 1999
    ..as well as decrease c-fos expression within trigeminal nucleus caudalis (TNC) in guinea pigs following chemical stimulation of small diameter meningeal afferent fibers...
  10. PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    Tony Yaksh; Fiscal Year: 1991
    ..2) "SP-LI release from the peripheral terminal occurs as a function of local thermal and chemical stimulation"...
  11. TRIGEMINOHYPOTHALAMIC TRACT
    Rami Burstein; Fiscal Year: 1999
    ..electrical stimulation of the dura, mechanical stimulation of the retina and lingual and oral mucous, and chemical stimulation of the nasal mucous...
  12. The Role of Tooth Mechanoreceptors in Jaw Movement
    Dean Dessem; Fiscal Year: 2006
    ..the membrane potential in primary afferent axons using in vivo intra-axonal recording during electrical and chemical stimulation of orofacial tissues. Mechanisms of PAD will be explored using GABAA and GABAB agonists and antagonists...
  13. ACTIVITY OF VISCERAL & NOCICEPTIVE TRIGEMINAL NEURONS
    Andrew Strassman; Fiscal Year: 1992
    ..vascular responses of trigeminal neurons by recording their activity extracellularly during mechanical and chemical stimulation of the lingual and middle meningeal arteries The arteries will be stimulated mechanically by intra-arterial ..
  14. KINESTHETIC MECHANISMS IN THE TRIGEMINAL SYSTEM
    Norman Capra; Fiscal Year: 2005
    ..Three specific hypotheses are proposed. 1) Noxious chemical stimulation of the muscle produces differential modulation of responses from spindle primaries and secondaries to ..
  15. OROFACIAL PAIN PATHWAYS
    BARRY GRUNWERG; Fiscal Year: 1993
    ..In addition to electrical stimulation, chemical stimulation of the tooth pulp with bradykinin will be studied because of the powerful excitation of C fevers by this ..
  16. BRAIN/PELVIC VISCERA INTERACTIONS IN PSYCHIATRIC DISEASE
    RITA VALENTINO; Fiscal Year: 2001
    ..This hypothesis will be tested by characterizing the effects of selective chemical stimulation of Barrington's nucleus on colonic intraluminal pressure: (3) Determine the role of Barrington's LC-..
  17. The Dorsomedial Hypothalamus and Responses to Stress
    JOSEPH DIMICCO; Fiscal Year: 2005
    ..DMH and the PVN and of local glutamate and AII AT-1 receptors in mediating the physiological response to chemical stimulation of the mPOA with PGE2, and (3) determine the effect of neuronal inhibition and of AII or glutamate receptor ..
  18. SPINAL ORGANIZATION OF FUNCTION
    Kevin McKenna; Fiscal Year: 1991
    ..findings have prompted a unifying hypothesis which proposes that ejaculation is induced by mechanical and chemical stimulation of the urethra by seminal fluids...
  19. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Experiment 2 examines whether chemical stimulation of cells in the LH is able to alter dopamine release, as measured by in vivo microdialysis, in the nucleus ..
  20. MECHANICAL CORRELATES OF NEUTROPHIL ACTIVATION
    ROBERT HOCHMUTH; Fiscal Year: 2000
    ..cortical tension, viscosity, stiffening due to activation, adhesion due to chemical bond formation, detachment due to the failure of chemical bonds and polymerization due to mechanical and chemical stimulation, to be precisely measured.
  21. HYPOTHALAMIC CONTROL OF PERIPHERAL CIRCULATION
    SELDEN SPENCER; Fiscal Year: 1990
    ..hypothalamic sites will then be correlated to arterial pressure and heart rate changes observed during chemical stimulation. The mechanism for any circulatory changes observed with stimulation will also be evaluated...
  22. CONNECTIONS OF THE CINGULATE GYRUS
    J Wyss; Fiscal Year: 1990
    ..Both cardiovascular and sympathetic nervous system responses to electrical and chemical stimulation of the midline cortex will be characterized in anesthetized and conscious rats...
  23. ESTROGEN EFFECTS ON CARDIOVASCULAR RESPONSE TO EXERCISE
    Marc Kaufman; Fiscal Year: 2005
    ..will be studied while the cats are paralyzed with vecuronium, and will be evoked by both electrical and chemical stimulation of the hypothalamic and mesencephalic locomotor regions...
  24. FOREBRAIN MODULATION OF OPIOID ANTINOCICEPTION
    FRED HELMSTETTER; Fiscal Year: 1999
    ..We will explore the neuropharmacology of this effect within the amygdala in greater detail and determine if chemical stimulation of the amygdala in this preparation causes the release of opioid peptides in the PAG...
  25. HEMODYNAMIC CONTROL OF PITUITARY-ADRENAL FUNCTION
    Donald Gann; Fiscal Year: 1992
    ..Studies will examine how local chemical stimulation or inhibition of these brain areas affects hormonal release directly and the endocrine response to ..
  26. FUNCTION AND GROWTH OF CORONARY COLLATERAL VESSELS
    John Longhurst; Fiscal Year: 1990
    ..and cyclooxygenase inhibition (to decrease prostaglandin production) and chronic PGE2 administration (chemical stimulation)...
  27. Lateral Pontine Neurons in the Control of Breathing
    DONALD MC CRIMMON; Fiscal Year: 2007
    ..with their selective role in respiratory rhythm and pattern control as predicted by computational models? Chemical stimulation and inhibition will identify discrete pontine neuron clusters that change the activity of identified VRG ..
  28. CI-2 Modulation of Spinal Processes: Supraspinal Effects
    Robert Foreman; Fiscal Year: 2006
    ..We previously demonstrated that chemical stimulation of C1-C2 neurons modulated spontaneous and visceral-evoked activity in lumbosacral spinal neurons and EMG ..
  29. A 3-D Microfluidic/Electronic Neural-Interfacing System
    Stephen DeWeerth; Fiscal Year: 2006
    ..of microfluidic channels into these towers to selectively inject nutrients and trophic factors and to apply chemical stimulation to localized regions of the tissue; and (3) the design of integrated circuits that amplify, multiplex, and ..
  30. REGULATION OF CBF BY THE ROSTRAL VENTROLATERAL MEDULLA
    EUGENE GOLANOV; Fiscal Year: 2006
    ..Two studies are proposed. Study 1, using autoradiographic measurement of rCBF and rCGU, electrical or chemical stimulation or blockade, and extracellular recording combined with juxtacellular staining, tests the hypothesis that ..
  31. INTESTINAL STIMULATION OF CNS CONTROL OF ABSORPTION
    Ronald Fogel; Fiscal Year: 2002
    Neurons in the nucleus of the solitary tract (NST) receive information regarding innocuous mechanical and chemical stimulation of the gastrointestinal tract and are part of the central circuitry involved in the parasympathetic regulation ..
  32. NEUROPSYCHOPHARMACOLOGICAL STUDIES OF ATTENTION
    Conan Kornetsky; Fiscal Year: 1980
    ..By means of electrical and chemical stimulation to various sites in the brain we hope to better understand the central mechanisms associated with the ..
  33. CARDIAC SENSORY INTEGRATION IN CERVICAL SPINAL CORD
    Robert Foreman; Fiscal Year: 1999
    ..Specific aims are designed to answer the following questions. 1) Does chemical stimulation or inactivation of neurons in high cervical segments affect activity of thoracic and lumbosacral ..
  34. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2003
    ..Intra-and internuclear circuits will be activated using electrical and focal chemical stimulation techniques...
  35. NEURONAL ORGANIZATION OF THE BASOLATERAL AMYGDALA
    ALEXANDER MCDONALD; Fiscal Year: 1993
    ..a technique that combines transmitter IHC with HRP retrograde tract tracing; 4) double-antigen IHC; and 5) chemical stimulation and lesioning techniques...
  36. Hypothalamic Effector Mechanisms: Stress and Fever
    JOSEPH DIMICCO; Fiscal Year: 2007
    ..stress, several paradigms for fever, and exposure to cold, (2) examine the response to selective chemical stimulation of the DHA and the VLD on heart rate, body temperature, and plasma levels of ACTH, (3) assess the effect of ..
  37. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  38. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  39. HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITY
    JOHN GLENDINNING; Fiscal Year: 2001
    ..A normative data-base for both screens will be established and made available to the scientific community. The assay procedures developed will be applicable by a single laboratory technician with limited experience. ..
  40. Taste Coding by Neural Circuitry in the Brain Stem
    PATRICIA DI LORENZO; Fiscal Year: 2005
    ..By describing the taste responsivity of inputs and outputs of NTS cells, data from this project will help provide an understanding of information processing in the NTS. ..
  41. Cholinergic modulation of odor responses
    Christiane Linster; Fiscal Year: 2003
    ....
  42. Cholinergic modulation of olfactory processing
    Christiane Linster; Fiscal Year: 2007
    ..These data should provide important insights into how neurodegenerative diseases affect olfactory sensation. [unreadable] [unreadable] [unreadable]..
  43. INTEROCEPTIVE DRUG CUE CONDITIONING OF COCAINE EFFECTS
    Robert Carey; Fiscal Year: 2002
    ..This research is important for the identification of the ways interoceptive drug cues can activate or inactivate cocaine conditioned stimuli. ..
  44. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  45. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2010
    ..Neuromodulation is involved in many major degenerative diseases of brain function;a better understanding of the functions of these systems will have a high impact on public health. ..
  46. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2007
    ..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
  47. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2004
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  48. HEDONICS AND DIETARY INTAKE OF FAT
    Richard Mattes; Fiscal Year: 2008
    ..This will be explored through stable isotope tracer studies for Aim 3. The proposed work will hold important public health, clinical, commercial and basic biological implications. [unreadable] [unreadable]..
  49. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2005
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  50. Food Rheology and Feeding in Lean and Obese Humans
    Richard Mattes; Fiscal Year: 2007
    ..abstract_text> ..
  51. CHEMOTRANSDUCTION IN THE CAROTID BODY
    Robert Fitzgerald; Fiscal Year: 2007
    ..Medical management of these situations could be greatly improved with a better understanding of the CB's transductive processes, possibly with genetic manipulation or drugs with highly focused effects. ..
  52. Temporal Integration in Nasal Lateralization
    Paul Wise; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. CENTRAL GUSTATORY ELECTROPHYSIOLOGY IN MICE
    Stuart McCaughey; Fiscal Year: 2005
    ..abstract_text> ..
  54. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 2001
    ....
  55. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  56. Role of Ghrelin in the Induction of Anxiogenic Behavior
    PAUL CURRIE; Fiscal Year: 2004
    ..abstract_text> ..
  57. TREATMENT FOR COMORBID ASTHMA AND PANIC DISORDER
    Paul Lehrer; Fiscal Year: 2002
    ..The principal outcome measures will be indices of high/low PD end-state functioning and improvement in asthma severity. A number of exploratory measures also will be analyzed. ..
  58. Linking Affect to Action: Critical Contributions of the Orbitofrontal Cortex
    Geoffrey Schoenbaum; Fiscal Year: 2006
    ..The participation of minorities and women has been emphasized at each level (organizers, speakers, students). Thus the conference will address important scientific, social, and educational issues. [unreadable] [unreadable] [unreadable]..
  59. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2008
    ..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
  60. DOPAMINE FUNCTION AFTER PRENATAL ETHANOL EXPOSURE
    Roh Yu Shen; Fiscal Year: 2008
    ..The information obtained from the proposed studies may help us to elucidate the etiology and treatment options of ADHD symptoms observed in many individuals with FASD. [unreadable] [unreadable] [unreadable]..
  61. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..