chemical depression

Summary

Top Publications

  1. ncbi Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats
    Hiroyuki Nishikawa
    Research and Development Center, Fuso Pharmaceutical Industries Ltd, 536 8523, Osaka, Japan
    Eur J Pharmacol 447:87-90. 2002
  2. pmc Immunomodulatory effects of the tobacco-specific carcinogen, NNK, on alveolar macrophages
    M J Therriault
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Quebec, Canada
    Clin Exp Immunol 132:232-8. 2003
  3. ncbi The effect of adrenomedullin, amylin fragment 8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat hearts
    Z Kaygisiz
    Department of Physiology, Medical Faculty, Osmangazi University, Eskisehir, Turkey
    Acta Physiol Hung 90:133-46. 2003
  4. ncbi Both estrogen and raloxifene cause G1 arrest of vascular smooth muscle cells
    K Takahashi
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata, Yamagata 990 9585, Japan
    J Endocrinol 178:319-29. 2003
  5. pmc Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats
    S M Gardiner
    School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 132:1625-9. 2001
  6. pmc Systematic analysis of the TGF-beta/Smad signalling pathway in the rhabdomyosarcoma cell line RD
    Hua Wang
    Department of Pathology, West China Hospital, Sichuan University, Chengdu, PR China
    Int J Exp Pathol 84:153-63. 2003
  7. ncbi Estrogen receptor beta mediates the inhibitory effect of estradiol on vascular smooth muscle cell proliferation
    Tokumitsu Watanabe
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cardiovasc Res 59:734-44. 2003
  8. ncbi Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
    C Diez
    , Versbacher Str. 5, D-97078, , Germany
    Cardiovasc Res 49:731-40. 2001
  9. ncbi [Effect of azithromycin on mucus secretion from nasal epithelium]
    Takeshi Shimizu
    Jpn J Antibiot 56:25-8. 2003
  10. ncbi Effects of halothane on contraction and intracellular calcium in ventricular myocytes from streptozotocin-induced diabetic rats
    A Rithalia
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Br J Anaesth 92:246-53. 2004

Research Grants

  1. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
  2. ANESTHETIC EFFECTS ON SENSORIMOTOR INTEGRATION
    JOSEPH ANTOGNINI; Fiscal Year: 2009
  3. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
  4. Relationship between Bio and Psych Correlates of PTSD
    Rachel Yehuda; Fiscal Year: 2005
  5. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
  6. Psychobiology of PTSD: A Decade of Progress
    Rachel Yehuda; Fiscal Year: 2005
  7. RELAXIN FAMILY PEPTIDES AND HEPATIC FIBROSIS
    Robert Bennett; Fiscal Year: 2009
  8. Biology of Risk of PTSD in Holocaust Survivor Offspring
    Rachel Yehuda; Fiscal Year: 2006
  9. Triazine library as a novel microtubule regulatory
    Young Tae Chang; Fiscal Year: 2006
  10. Neurophysiologic Development Responses to Surgery
    DOUGLAS RIRIE; Fiscal Year: 2007

Detail Information

Publications225 found, 100 shown here

  1. ncbi Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats
    Hiroyuki Nishikawa
    Research and Development Center, Fuso Pharmaceutical Industries Ltd, 536 8523, Osaka, Japan
    Eur J Pharmacol 447:87-90. 2002
    ..These dual actions of PAR-2 would result in gastric mucosal cytoprotection...
  2. pmc Immunomodulatory effects of the tobacco-specific carcinogen, NNK, on alveolar macrophages
    M J Therriault
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Quebec, Canada
    Clin Exp Immunol 132:232-8. 2003
    ..Thus, in addition to its carcinogenic effects, NNK may contribute to the lung immunosuppression observed in tobacco smokers...
  3. ncbi The effect of adrenomedullin, amylin fragment 8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat hearts
    Z Kaygisiz
    Department of Physiology, Medical Faculty, Osmangazi University, Eskisehir, Turkey
    Acta Physiol Hung 90:133-46. 2003
    ..Amylin produces a biphasic inotropic effect and evokes a positive chronotropy. CGRP causes positive inotropic, positive chronotropic and vasodilatory effects in isolated rat hearts...
  4. ncbi Both estrogen and raloxifene cause G1 arrest of vascular smooth muscle cells
    K Takahashi
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata, Yamagata 990 9585, Japan
    J Endocrinol 178:319-29. 2003
    ....
  5. pmc Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats
    S M Gardiner
    School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 132:1625-9. 2001
    ..This is in contrast to recent findings with human U-II in non-human primates, but is consistent with effects on human isolated resistance vessels...
  6. pmc Systematic analysis of the TGF-beta/Smad signalling pathway in the rhabdomyosarcoma cell line RD
    Hua Wang
    Department of Pathology, West China Hospital, Sichuan University, Chengdu, PR China
    Int J Exp Pathol 84:153-63. 2003
    ..The RD cell line is a suitable model to study the TGF-beta autocrine loop involved in growth and differentiation of RMS...
  7. ncbi Estrogen receptor beta mediates the inhibitory effect of estradiol on vascular smooth muscle cell proliferation
    Tokumitsu Watanabe
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cardiovasc Res 59:734-44. 2003
    ..Both ER subtypes, classical ER (ERalpha) and the newly identified ER subtype (ERbeta), are expressed in VSMCs. However, it remains unknown which receptor plays the critical role in the inhibitory effect on VSMC proliferation...
  8. ncbi Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
    C Diez
    , Versbacher Str. 5, D-97078, , Germany
    Cardiovasc Res 49:731-40. 2001
    ..CONCLUSION: These results support an important role for Akt in senescence and regulation of cardiac fibroblast cell proliferation...
  9. ncbi [Effect of azithromycin on mucus secretion from nasal epithelium]
    Takeshi Shimizu
    Jpn J Antibiot 56:25-8. 2003
  10. ncbi Effects of halothane on contraction and intracellular calcium in ventricular myocytes from streptozotocin-induced diabetic rats
    A Rithalia
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Br J Anaesth 92:246-53. 2004
    ..A previous report suggested that halothane inhibited contraction to a lesser extent in papillary muscle from diabetic animals and so the aim of this study was to investigate possible mechanisms underlying this effect...
  11. ncbi YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits the spontaneous contractions of isolated pregnant rat myometrium
    Ali Cetin
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey
    J Pharmacol Sci 94:19-24. 2004
    ..This effect of YC-1 is significantly reduced by the methylene blue and TEA, suggesting the activation of soluble guanylate cyclase and Ca(2+)-sensitive K(+) channels as the mechanisms of action...
  12. ncbi Myocardial effects of halothane and sevoflurane in diabetic rats
    Jean Stephane David
    Laboratoire d Anesthésiologie, Departement d Anesthesie Reanimation, Centre Hospitalier Universitaire Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Anesthesiology 100:1179-87. 2004
    ..Diabetes induces significant myocardial abnormalities, but the effects of halogenated anesthetics on this diseased myocardium remain a matter of debate...
  13. ncbi Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes
    J Leonova
    Institute of Clinical Neuroscience, , , Sweden
    Am J Physiol Cell Physiol 281:C1495-503. 2001
    ..These results suggest that ET-1 impairs the high-affinity glutamate uptake in cultured astrocytes through a G protein-coupled mechanism, involving PKC and changes in intracellular Ca(2+)...
  14. ncbi Cocaine long-term administration induces myocardial depressant effects and adrenoceptors desensitization
    Eduardo Romero Vecchione
    Laboratory of Cardiovascular Research, Departament of Pharmacology and Pathophysiology, José María Vargas School of Medicine, Central University of Venezuela, Edif II, Plaza San Lorenzo, San Jose, Caracas 1010, Venezuela
    Acta Cient Venez 53:225-31. 2002
    ..Extrapolated to clinical grounds, this mechanism could explain some clinical cases of heart failure reported in cocaine overdosed addicts...
  15. ncbi Inhibitory effects of atropine and hexamethonium on the angiotensin II-induced contractions of rat anococcygeus smooth muscles
    Márcio Augusto Fressatto de Godoy
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av dos Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 367:176-82. 2003
    ..Results suggest that there is a positive interaction between Ang II and cholinergic transmission in the rat anococcygeus smooth muscle mediated by angiotensin receptors located on pre-ganglionic cells...
  16. pmc 4-hydroxynonenal decreases interleukin-6 expression and protein production in primary rat Kupffer cells by inhibiting nuclear factor-kappaB activation
    Stephen W Luckey
    Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Pharmacol Exp Ther 302:296-303. 2002
    ..These results have functional implications in that 4-HNE may interfere with the ability of Kupffer cells to produce cytokines proposed to play an important role in liver regeneration...
  17. ncbi Inhibition of testosterone production by propylthiouracil in rat Leydig cells
    Yu Chung Chiao
    Department of Physiolog, School of Medicine, National Yang Ming University, No 155 Section 2, Li Nung Street, Taipei 11221, Taiwan, Republic of China
    Biol Reprod 67:416-22. 2002
    ..These results suggest that PTU acts directly on rat Leydig cells to diminish testosterone production by inhibiting P450(scc) function and StAR expression...
  18. pmc Evidence for a GABA(B) receptor component in the spinal action of Substance P (SP) on arterial blood pressure in the awake rat
    Jonathan Brouillette
    Department of Physiology, Faculty of Medicine, Universite de Montreal C P 6128, Succursale Centre Ville, Quebec, Canada, H3C 3J7
    Br J Pharmacol 136:1169-77. 2002
    ..This mechanism may have a physiological significance in the spinal reflex autonomic control of arterial blood pressure...
  19. ncbi Inhibitory effects of intravenous anaesthetic agents on K(+)-evoked glutamate release from rat cerebrocortical slices. Involvement of voltage-sensitive Ca(2+) channels and GABA(A) receptors
    Masatou Kitayama
    Department of Anesthesiology, University of Hirosaki, School of Medicine, Hirosaki 036 8563, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:246-53. 2002
    ....
  20. ncbi [Hydrocortisone inhibits nicotinic acetylcholine receptor response in the rat airway parasympathetic ganglion neurons]
    Masamichi Seki
    Cellular and System Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 93:23-8. 2002
    ..Hydrocortisone suppressed the maximum response of the ACh concentration-response curve, indicating that the inhibitory action of hydrocortisone on the nicotinic ACh response is non-competitive...
  21. pmc Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes
    Joanne Layland
    Department of Cardiology, GKT School of Medicine, King s College London Denmark Hill Campus, Bessemer Road, London SE5 9PJ, UK
    J Physiol 540:457-67. 2002
    ..4-fold; P < 0.01) in troponin I phosphorylation compared to control, untreated hearts. These results suggest that the reduction in myofilament Ca(2+) responsiveness produced by DEA/NO results from phosphorylation of troponin I by PKG...
  22. ncbi The influence of gender, diabetes, and acetaldehyde on the intrinsic contractile properties of isolated rat myocardium
    R A Brown
    Department of Biology, Morgan State University, Baltimore, MD 21251, USA
    Cardiovasc Toxicol 1:35-42. 2001
    ....
  23. ncbi Cyclosporine attenuates the autonomic modulation of reflex chronotropic responses in conscious rats
    Mahmoud M El-Mas
    Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Egypt
    Can J Physiol Pharmacol 80:766-76. 2002
    ..More importantly, the study provides the first pharmacological evidence that CyA attenuates reflex chronotropic responses via impairment of the autonomic modulation of the baroreceptor neural pathways...
  24. pmc Role of nitric oxide/cyclic GMP in myocardial adenosine A1 receptor-inotropic response
    Leonor Sterin-Borda
    Cátedras de Farmacología, Facultad de Odontologia, Universidad de Buenos Aires, Argentina
    Br J Pharmacol 135:444-50. 2002
    ..This, in turn, triggers cascade reactions involving calcium/calmodulin and PKC, leading to activation of NOS and soluble guanylate cyclase...
  25. ncbi Effect of aging on cardiac contractility in a rat model of chronic daunorubicin cardiotoxicity
    Barry J Cusack
    Clinical Pharmacology and Gerontology Research Unit, Veterans Affairs Medical Center, Boise, ID 83702, USA
    Cardiovasc Toxicol 2:99-109. 2002
    ..This suggests that chronic daunorubicin cardiotoxicity increases with age, at least partly resulting from sarcoplasmic reticulum dysfunction caused by increased anthracycline exposure...
  26. ncbi Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin
    Irina Rozovsky
    Neurogerontology Division, Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089 0191, USA
    Endocrinology 143:636-46. 2002
    ....
  27. pmc Negative inotropic effects of tumour necrosis factor-alpha and interleukin-1beta are ameliorated by alfentanil in rat ventricular myocytes
    D J Duncan
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    Br J Pharmacol 150:720-6. 2007
    ..This study characterised the effects of TNF-alpha and IL-1beta on contraction and the Ca(2+) transient and investigated whether depressed ventricular function was ameliorated by alfentanil...
  28. ncbi Expression of the beacon gene in the rat pancreatic islets: opposite effects of beacon (47-73) protein (ubiquitin-like protein 5) on insulin secretion in vivo and insulin release by isolated islets
    Krzysztof W Nowak
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Poznan, Poland
    Pancreas 29:99-103. 2004
    ..We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible beacon protein effects on insulin secretion...
  29. ncbi In situ inhibition of uterine activity by indomethacin: possible relevance to preterm labor prevention after fetal surgery
    Jennifer Garza
    Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 39:1173-5. 2004
    ..This report is an analysis of the effects of local indomethacin delivery on uterine activity in vitro...
  30. ncbi Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells
    Attila Borbely
    Division of Clinical Physiology, Institute of Cardiology, UD MHSC, P O Box 1, H 4004 Debrecen, Hungary
    Cardiovasc Res 67:225-33. 2005
    ..In the present study, an attempt was made to elucidate the molecular background of peroxynitrite-evoked alterations in the human myocardium...
  31. ncbi Angiotensin II-induced negative inotropy in rat ventricular myocytes: role of reactive oxygen species and p38 MAPK
    Julieta Palomeque
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 60 y 120, La Plata 1900, Argentina
    Am J Physiol Heart Circ Physiol 290:H96-106. 2006
    ..Furthermore, they reveal p38 MAPK as the putative effector of the reduction in myofilament responsiveness to Ca2+ and the decrease in contractility induced by the peptide...
  32. ncbi Cardiac effects of oxytocin: is there a role for this peptide in cardiovascular homeostasis?
    R H Costa-E-Sousa
    Laboratories of Cellular and Molecular Cardiology, Biophysical Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil
    Regul Pept 132:107-12. 2005
    ..001), returning to control value thereafter. Thus, oxytocin is able to promote directly negative inotropic and chronotropic effects, but its in vivo effect also involves a reflex mechanism, originated from its pressor effect...
  33. ncbi Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells
    Ai Yu Shen
    Basic Medical Science Education Center, Fooyin University Ta Liao, Kaohsiung County, Taiwan
    Am J Chin Med 33:747-58. 2005
    ....
  34. ncbi An unexpected negative inotropic effect of prostaglandin F2alpha in the rat heart
    Nenad Jovanović
    Division of Experimental Pharmacology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
    Prostaglandins Other Lipid Mediat 80:110-9. 2006
    ..This effect of PGF(2alpha) could contribute to cardiac dysfunction in conditions of systemic and myocardial inflammation...
  35. ncbi Intracellular peptides of natriuretic peptide receptor-C inhibit vascular hypertrophy via Gqalpha/MAP kinase signaling pathways
    Yuan Li
    Department of Physiology, and Groupe de recherche sur le système nerveux autonome, GRSNA Faculty of Medicine, University of Montreal, Canada
    Cardiovasc Res 72:464-72. 2006
    ....
  36. ncbi Peptide YY (PYY)3-36 modulates thyrotropin secretion in rats
    K J Oliveira
    Laboratório de Endocrinologia Molecular, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949 900, Brazil
    J Endocrinol 191:459-63. 2006
    ..In such a situation, systemically injected PYY3-36 was able to acutely activate the thyrotrope axis, suggesting a new role for PYY3-36 as a regulator of the hypothalamic-pituitary-thyroid axis...
  37. ncbi Regulation of the expression and secretion of urocortin 2 in rat pituitary
    Takahiro Nemoto
    Department of Physiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Endocrinol 192:443-52. 2007
    ..These results suggest that the mRNA expression and secretion of Ucn 2 in POMC cells of the pituitary are positively regulated by CRF and negatively regulated by glucocorticoids...
  38. ncbi Effects of bupivacaine, levobupivacaine and ropivacaine on myocardial relaxation
    Jean Stephane David
    Laboratoire d Anesthésiologie, Université Claude Bernard et Département d Anesthésie Réanimation, Hôpital Edouard Herriot et Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France
    Can J Anaesth 54:208-17. 2007
    ..The present study aimed to compare the effects of LAAs on rat myocardium...
  39. pmc Protein kinase A is activated by the n-3 polyunsaturated fatty acid eicosapentaenoic acid in rat ventricular muscle
    Norbert Szentandrássy
    Department of Medicine, University of Manchester, Core Technology Facility, Grafton Street, Manchester M13 9PT, UK
    J Physiol 582:349-58. 2007
    ..This is a further level of protection for the heart in addition to the well-documented antiarrhythmic qualities of these fatty acids...
  40. ncbi COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia
    Katrin Birkenmeier
    Innere Klinik B, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Am J Physiol Heart Circ Physiol 293:H2148-54. 2007
    ..01 vs. control). In conclusion, the cardiodepressive effect of postischemic effluent is COX-2 dependent and protective against Ca(2+) overload in the cells...
  41. ncbi Semaphorin 4D inhibits collagen synthesis of rat pulp-derived cells
    Makoto Abe
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    Arch Oral Biol 53:27-34. 2008
    ..We analysed the expression of membrane-associated Semaphorin 4D (Sema4D) in tooth germs, and examined its potential role in regulating the differentiation of rat incisor pulp-derived cells in vitro...
  42. ncbi A paradoxical inhibitory effect of oestradiol-17beta on GnRH self-priming in pituitaries from tamoxifen-treated rats
    Jose E Sanchez-Criado
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    J Endocrinol 186:43-9. 2005
    ..Although other explanations may exist, altogether these results suggested that E2, via an ER different from classical ER, inhibits the GnRH self-priming elicited by TX...
  43. ncbi Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells
    F D'Acquisto
    The William Harvey Research Institute, Centre for Biochemical Pharmacology, Barts and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Rheumatology (Oxford) 47:636-9. 2008
    ..Here, we investigated the effects of glucocorticoids (GCs) on Anx-A1 expression in T cells in vitro and in vivo...
  44. ncbi Inhibition of iNOS augments cardiovascular action of noradrenaline in streptozotocin-induced diabetes
    Xing Cheng
    Department of Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Cardiovasc Res 64:298-307. 2004
    ..The aim was to determine if inducible nitric oxide synthase (iNOS) contributes to depressed cardiovascular function at the acute phase of streptozotocin-induced diabetes...
  45. ncbi [Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]
    Yutaka Inoue
    Laboratory for Discovery Research, Pharmaceutical Research and Development Division, Senju Pharmaceutical Co Ltd
    Clin Calcium 14:84-91. 2004
    ..These results suggest that SN-6 is expected to be pharmacological tools to study the roles of the exchanger and a new anti-ischemic drug...
  46. ncbi Insulin determines leptin responses during a glucose challenge in fed and fasted rats
    C G Walker
    Human Nutrition Unit, University of Sydney, NSW, Australia
    Int J Obes (Lond) 29:398-405. 2005
    ..The aim of this study was to assess whether the prior nutritional state altered the leptin secretory response to an acute glucose challenge, and to determine potential mechanisms...
  47. ncbi Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart
    G Ross
    Institute of Physiology, Justus Liebig University, Giessen, Germany
    Endocrinology 146:2221-8. 2005
    ..The results obtained with isolated cardiomyocytes suggest that myocyte-derived NO, rather than vascular NO, is responsible for this effect. cGMP seems to be the downstream signal of produced NO...
  48. ncbi [Antiobesity actions of Zingiber officinale Roscoe]
    Li Kun Han
    Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto City 862 8502, Japan
    Yakugaku Zasshi 125:213-7. 2005
    ..officinale Roscoe in mice fed a high-fat diet may be due in part to the inhibition of intestinal absorption of dietary fat by the active compounds of Z. officinale Roscoe...
  49. ncbi Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis
    Cecilia Mundina-Weilenmann
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, 60 y 120, 1900 La Plata, Argentina
    Cardiovasc Res 66:114-22. 2005
    ..To assess the time course of phosphorylation of phospholamban residues, the underlying mechanisms determining these phosphorylations, and their functional impact on the mechanical recovery during acidosis...
  50. ncbi HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo
    Ki Hoon Han
    Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
    Circulation 111:1439-47. 2005
    ..The present study investigated whether 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition affects CCR2 gene expression and CCR2-dependent monocyte recruitment...
  51. ncbi Inhibition of CYP450scc expression in dioxin-exposed rat Leydig cells
    K P Lai
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People s Republic of China
    J Endocrinol 185:519-27. 2005
    ..The data indicate that TCDD can modulate cAMP signaling in rat Leydig cells to affect the process of steroidogenesis...
  52. ncbi Antiatherogenic effects of phyllanthus emblica associated with corilagin and its analogue
    Weigang Duan
    Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing 210038, China
    Yakugaku Zasshi 125:587-91. 2005
    ....
  53. ncbi Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation
    Michael C Oh
    Vollum Institute, Oregon Health and Sciences University, Portland, 97239, USA
    J Biol Chem 281:752-8. 2006
    ..whereas chemical potentiation (forskolin/rolipram treatment) persistently increased this to 60% and chemical depression (N-methyl-D-aspartate treatment) decreased it to 10%...
  54. ncbi [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]
    Salah Alla
    Unite de Phytopharmacie et Mediateurs Chimiques, INRA, 78026 Versailles, France
    C R Biol 325:941-6. 2002
    ..Two other new compounds in insects were also identified in both leafhopper nymphs and adults: 2-(2-hydroxypropoxy)-1-propanol and 3,3'-oxybis-2-butanol...
  55. ncbi A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats
    Yoshihisa Kato
    School of Pharmaceutical Sciences, COE Program in the 21st Century, University of Shizuoka, 52 1, Yada, Shizuoka 422 8526, Japan
    Toxicol Sci 81:309-15. 2004
    ..Furthermore, even in Wistar rats, the PCB-mediated decrease in serum T(4) level might occur not only through the increase in hepatic T(4)-UDP-GT but also via formation of hydroxylated PCB metabolites...
  56. pmc SR33805, a Ca2+ antagonist with length-dependent Ca2+ -sensitizing properties in cardiac myocytes
    Olivier Cazorla
    INSERM U 390, Unite de Recherches de Physiopathologie Cardiovasculaire, CHU Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Br J Pharmacol 139:99-108. 2003
    ..These effects are attributable to both an increase in the maximal Ca(2+)-activated force and a length-dependent Ca(2+)-sensitization...
  57. ncbi Antitumor activity of the procyanidins from Pinus koraiensis bark on mice bearing U14 cervical cancer
    Kun Li
    Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University, P R China
    Yakugaku Zasshi 127:1145-51. 2007
    ..The mechanism of PKBPE antitumor activity might be associated with free radical production inhibition and regulation of the expression of Ki-67, mutant p53 and Bcl-2 protein...
  58. ncbi The effect of propofol on human gastric and colonic muscle contractions
    T L Lee
    Department of Anaesthesia, National University of Singapore, Singapore
    Anesth Analg 89:1246-9. 1999
    ..Fat emulsion 10% (Intralipid), the solvent for propofol, had no effect on either the spontaneous activity or the Ach-induced contraction of gastric and colonic smooth muscles...
  59. ncbi [Novel therapeutic strategy for diabetic nephropathy]
    Motohide Isono
    Department of Medicine, Shiga University of Medical Science
    Nihon Rinsho 63:464-8. 2005
  60. ncbi Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells
    Flore Mulhaupt
    Cardiology Division, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva 4, Switzerland
    Cardiovasc Res 59:755-66. 2003
    ....
  61. pmc Inhibition of arthritis by systemic administration of endostatin in passive murine collagen induced arthritis
    D Kurosaka
    Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Japan
    Ann Rheum Dis 62:677-9. 2003
    ..To investigate the arthritis inhibiting effect of endostatin, known to have potent antiangiogenic activity, systemically given to animal models of rheumatoid arthritis (RA)...
  62. ncbi [Effects of NIK-228 on gastric acid secretion in rats using the congo red sprayed method]
    M Kagoshima
    Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Nihon Yakurigaku Zasshi 98:99-111. 1991
    ..These results suggested that antisecretory effects of NIK-228 were caused by the central vagal systems...
  63. ncbi Comparison of depressant actions of orphenadrine and diazepam on hypertonic skeletal muscle activity
    H E Williamson
    Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242
    Arch Int Pharmacodyn Ther 301:112-21. 1989
    ..It would appear that both agents are acting via the central nervous system when they suppress hypertonic skeletal muscle activity, but only orphenadrine exhibits protective indices consistently greater than 1...
  64. ncbi Rat luteinizing hormone receptor messenger ribonucleic acid expression and luteolysis: inhibition by prostaglandin F2 alpha
    E Bjurulf
    Department of Physiology, University of Umea, Sweden
    Biol Reprod 54:1350-5. 1996
    ..We conclude that luteal LH receptor mRNA expression is under direct regulatory control by PGF2 alpha in a both time-and dose-dependent manner and thereby may decisively contribute to the inhibition of LH responsiveness during luteolysis...
  65. ncbi [NPY as a periarterial sympathetic transmitter in isolated vessel]
    S Chiba
    Department of Pharmacology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
    Nippon Yakurigaku Zasshi 117:187-94. 2001
    ....
  66. ncbi Singlet oxygen inhibits agonist-induced P-selectin expression and formation of platelet aggregates
    T W Stief
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of Philipps University, Marburg, Germany
    Clin Appl Thromb Hemost 7:219-24. 2001
    ..The physiologic signal action and the direct anticoagulant action of 1O2 (released by chloramines such as vancomycin) might be a new principle for pharmacologic intervention in atherothrombosis...
  67. ncbi Cyclosporine a and FK506 inhibit transcriptional activity of the human mineralocorticoid receptor: a cell-based model to investigate partial aldosterone resistance in kidney transplantation
    Christine E Deppe
    INSERM, U 478, IFR02, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, BP 416, 75870 Paris Cedex 18, France
    Endocrinology 143:1932-41. 2002
    ..They suggest that ion transport alterations in renal graft recipients are in part induced by impaired hMR function...
  68. ncbi Antiproliferative effect of a polysaccharide fraction of a 20% methanolic extract of stinging nettle roots upon epithelial cells of the human prostate (LNCaP)
    J J Lichius
    Department of Pharmaceutical Biology, Philipps University, Marburg, Germany
    Pharmazie 54:768-71. 1999
    ..No cytotoxic effect of POLY-M on cell proliferation was observed. The in vitro results show for the first time an antiproliferative effect of Urtica compounds on human prostatic epithelium and confirm our previous in vivo findings...
  69. pmc Partial purification and some properties of delta1-pyrroline-5-carboxylate reductase from Escherichia coli
    J J Rossi
    J Bacteriol 129:108-14. 1977
    ..PCA reductase is not repressed by growth in the presence of proline, but it is inhibited by the reaction end products, proline and NADP...
  70. ncbi IFN-tau exhibits potent suppression of human papillomavirus E6/E7 oncoprotein expression
    J A Johnson
    Department of Microbiology, Greenville Hospital System Clemson University Biomedical Cooperative, Clemson, SC 29634, USA
    J Interferon Cytokine Res 19:1107-16. 1999
    ..Sequences/structures unique to IFN-tau could allow for alternative IFN/receptor interactions and may explain the differences in biologic function...
  71. ncbi Effects of dexamethasone on proliferation, activity, and cytokine secretion of normal human bone marrow stromal cells: possible mechanisms of glucocorticoid-induced bone loss
    C H Kim
    Division of Endocrinology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea
    J Endocrinol 162:371-9. 1999
    ..As both basal and PTH-stimulated production of IL-6 and IL-11 are decreased by dexamethasone, the increased bone resorption observed in glucocorticoid-induced osteopenia does not appear to be mediated by IL-6 or IL-11...
  72. ncbi Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist
    Yasuharu Kimura
    Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Eur J Pharmacol 483:37-43. 2004
    ....
  73. ncbi Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation
    Helmy M Siragy
    Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Hypertension 45:133-7. 2005
    ..These data demonstrate for the first time to our knowledge that AT2 receptors regulate the renin-angiotensin system activity via inhibition of renin synthesis...
  74. ncbi Basic amino acid transport in Escherichia coli
    B P Rosen
    J Biol Chem 246:3653-62. 1971
  75. ncbi Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway
    Y Hirashima
    Department of Metabolic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
    J Endocrinol 179:253-66. 2003
    ..Our results indicate that insulin regulates IRS-1 and IRS-2 through different mechanisms and that insulin represses IRS-2 gene expression via a PI 3-kinase/Akt pathway...
  76. ncbi The frequency and timing of respiratory depression in 1524 postoperative patients treated with systemic or neuraxial morphine
    Arie Shapiro
    Department of Anesthesiology, Critical Care and Pain Management, Meir Hospital, Kfar Saba 44281, Israel
    J Clin Anesth 17:537-42. 2005
    ..To describe the frequency and timing of intravenous patient-controlled analgesia (IV-PCA) or neuraxial morphine-induced postoperative respiratory depression...
  77. ncbi Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption
    Dennis A Chakkalakal
    Orthopaedic Research Laboratory, VA Medical Center, Omaha, NE 68105, USA
    Alcohol 36:201-14. 2005
    ..We conclude that ethanol (as 36% of calories) in the rat diet, especially during the postinjury period, was solely responsible for the observed inhibition of bone repair...
  78. ncbi Estradiol and its membrane-impermeable conjugate estradiol-BSA inhibit tamoxifen-stimulated prolactin secretion in incubated rat pituitaries
    R Aguilar
    Department of Cellular Biology, Physiology and Immunology, University of Córdoba Avda, Menendez Pidal s n, 14004 Cordoba, Spain
    Reproduction 131:763-9. 2006
    ..Taken together, these data argue in favor of the presence of specific membrane recognition sites for E in the lactotrope involved in steroid-specific E2 inhibition of TX-stimulated PRL secretion...
  79. ncbi Long-term voluntary ethanol consumption induces impairment of the mechanical performance in the papillary muscle of Sardinian alcohol-preferring rats
    D Licheri
    Department of Applied Sciences for Biosystems, Division of Human Physiology and Nutrition, University of Cagliari, Via Porcell 4, I-09124 Cagliari, Italy
    Alcohol Alcohol 36:44-7. 2001
    ..5 times. These results indicate that long-term ethanol consumption impairs the mechanical performance of sP papillary muscle, inducing a negative inotropic effect...
  80. ncbi Adrenergic inhibition of endogenous acetylcholine release on postganglionic cardiac vagal nerve terminals
    T Akiyama
    Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Cardiovasc Res 46:531-8. 2000
    ..The aim was to examine the adrenergic modulation of endogenous acetylcholine (ACh) release from vagal nerve terminals in the in vivo heart...
  81. ncbi Early postoperative indicators of late outcome in acromegalic patients
    Jun A Takahashi
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Japan
    Clin Endocrinol (Oxf) 60:366-74. 2004
    ..We performed a retrospective study to assess whether the attainment of these values in the early postoperative period was predictive of future IGF-1 normalisation and disease inactivity...
  82. ncbi Analgesia, pruritus, and ventilation exhibit a dose-response relationship in parturients receiving intrathecal fentanyl during labor
    N L Herman
    Department of Anesthesiology, New York Presbyterian Hospital Weill Medical College of Cornell University, NY 10021, USA
    Anesth Analg 89:378-83. 1999
    ..Even in the absence of overt signs or symptoms of somnolence, intrathecal fentanyl at doses within the effective analgesic range induced a change in ventilation that may last longer than the 30-min period we studied...
  83. ncbi Medial prefrontal cortex modulation of the baroreflex parasympathetic component in the rat
    L B M Resstel
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, Ribeirao Preto, SP 14090 090, Brazil
    Brain Res 1015:136-44. 2004
    ..The observation that CoCl2 and lidocaine microinjections had similar effects on the baroreflex also suggests that this modulation involves local synaptic neurotransmission within the vMPFC...
  84. ncbi NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium
    J Fox
    NPS Pharmaceuticals, Inc, Salt Lake City, Utah
    J Pharmacol Exp Ther 290:473-9. 1999
    ..Moreover, the data add pharmacological support to the view that the Ca(2+) receptor is the primary molecular entity regulating systemic Ca(2+) homeostasis...
  85. ncbi Cardiodepression by tumor necrosis factor-alpha
    U Muller-Werdan
    Department of Medicine III, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Germany Tel 49 345 557 4545, Fax 49 345 557 4546, E mail
    Eur Cytokine Netw 9:689-91. 1998
    ..Whether secondary cytokines induced by TNF-alpha in cardiomyocytes contribute to cardiodepression or whether apoptotic signals activated by TNF-alpha are involved in the cardiodepressive pathways is presently unknown...
  86. ncbi IL-4 inhibits mouse mast cell Fc epsilonRI expression through a STAT6-dependent mechanism
    J J Ryan
    Department of Biology, Virginia Commonwealth University, Richmond 23284, USA
    J Immunol 161:6915-23. 1998
    ..These data argue for a homeostatic role of IL-4 in the regulation of Fc epsilonRI expression, a role that could be critical to understanding atopic disease...
  87. ncbi Buckwheat protein extract suppression of the growth depression in rats induced by feeding amaranth (Food Red No. 2)
    J Kayashita
    Kissei Pharmaceutical Co, Ltd, Nagano, Japan
    Biosci Biotechnol Biochem 60:1530-1. 1996
    ..The results show that BWPE-containing diet suppressed the growth depression induced by the dietary addition of 5% amaranth...
  88. ncbi Alterations in follicular dynamics and steroidogenic abilities induced by heat stress during follicular recruitment in goats
    M Ozawa
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba shi, Ibaraki 305 8572, Japan
    Reproduction 129:621-30. 2005
    ..These results indicate that heat stress during follicular recruitment suppresses subsequent growth to ovulation, accompanied by decreased LH receptor level and oestradiol synthesis activity in the follicles...
  89. ncbi Limonoids from Swietenia macrophylla and S. aubrevilleana
    B S Mootoo
    Departments of Chemistry and Plant Sciences, University of the West Indies, St Augustine, Trinidad and Tobago, and Department of Chemistry, University of Toronto, Ontario, Canada
    J Nat Prod 62:1514-7. 1999
    ..Four of the compounds were subjected to an antifeedant bioassay on the final instar larvae of Spodoptera frugiperda. The antifeedant activity was comparable to that of bicyclononanolides previously tested...
  90. ncbi CGP 35348 and CGP 55845A block the baclofen-induced depression of dorsal root evoked potentials in lumbar motoneurons of the neonatal rat
    L Vinay
    CNRS, UPR Neurobiologie et Mouvements, Marseille, France
    Neurosci Lett 214:103-6. 1996
    ..The two GABAB receptor antagonists, CGP 35348 and CGP 55845A blocked the effects of baclofen. These two compounds may be useful tools to study the evolution of GABAB receptor-mediated presynaptic inhibition during ontogenesis...
  91. ncbi Nafamostat mesilate suppresses NF-kappaB activation and NO overproduction in LPS-treated macrophages
    Soichi Noguchi
    Department of Obstetrics and Gynecology, Okayama University Medical School, 2 5 1 Shikata, Okayama Okayama 700 8558, Japan
    Int Immunopharmacol 3:1335-44. 2003
    ..Our observations suggest that nafamostat mesilate is a candidate agent for various diseases such as ischemia-reperfusion, graft rejection, inflammatory diseases, and autoimmune diseases, in which iNOS and/or NF-kappaB are upregulated...
  92. ncbi [Mechanism of negative inotropic effect of tumor necrosis factor-alpha on rat myocardium]
    Chen Fu
    Department of Physiology, College of Medical Sciences, Zhejiang University, Hangzhou 310031, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 32:181-6. 2003
    ..To investigate the mechanism of the negative inotropic effect of tumor necrosis factor-alpha (TNF-alpha) in cardiomyocytes...
  93. ncbi Inhibition of glycosylation processing alters the growth parameters of cells transformed by the oncogene of simian sarcoma virus
    A Hadwiger Fangmeier
    , , Federal Republic of Germany
    Arch Virol 104:339-45. 1989
    ..The inhibitor did not change cell morphology, but specific growth parameters such as serum- and anchorage-independence were lost...
  94. ncbi Effects of high doses of cortisol on innate cellular immune response of seabream (Sparus aurata L.)
    Maria Angeles Esteban
    Fish Innate Immune System Group, Department of Cell Biology, Faculty of Biology, University of Murcia, 30, 100 Murcia, Spain
    Gen Comp Endocrinol 137:89-98. 2004
    ..The present results demonstrate that cortisol plays an important role in the down-regulation of phagocytic but not of cytotoxic activity in seabream leucocytes...
  95. ncbi Effects of hypochlorite and hydrogen peroxide on cardiac autonomic receptors and vascular endothelial function
    Carsten Sand
    Department of Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Exp Pharmacol Physiol 30:249-53. 2003
    ..7. From these data, we conclude that hypochlorite exerts more toxic properties than its precursor hydrogen peroxide, leading to substantial physiological alterations in cardiac and vascular tissue...
  96. ncbi The hypothermic effects of dl-tetrahydropalmatine in rats
    M T Lin
    Department of Medical Research, Chi Mei Medical Center, Yung Kang City, 710, Tainan Hsien, Taiwan
    Neurosci Lett 315:53-6. 2001
    ..The results suggest involvement of serotoninergic antagonism in the THP-induced hypothermia in rats..
  97. ncbi Injection of endothelin-1 into the raphe obscurus of rats induces depressor responses predominantly through endothelin ET(A) receptors
    M D'AMICO
    Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, 2nd University of Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 359:471-6. 1999
    ..The in vivo study showed that ET(A) receptors are the predominant mediators of depressor responses induced by endothelin-1 injected into this nucleus...
  98. ncbi Testosterone suppresses circadian responsiveness to social cues in the diurnal rodent Octodon degus
    Tammy J Jechura
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
    J Biol Rhythms 18:43-50. 2003
    ..This hormonal effect likely occurs by altering sensory system functions or CNS response to sensory information...
  99. ncbi Negative inotropic activity of the calcium antagonists isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardium
    R H Schwinger
    Medical Clinic I, Grosshadern Hospital, , Germany
    Am J Hypertens 4:185S-187S. 1991
    ..Thus, to minimize cardiodepressant risk, the use of calcium antagonists with weak negative inotropic effects at relevant concentrations should be preferred, especially in the case of patients with compromised cardiac function...
  100. ncbi Effect of acute anaesthesia on synthesis of contractile and non-contractile proteins of heart muscle and mixed proteins of types I and II fibre rich skeletal muscles of rat
    T Siddiq
    Department of Cardiology, King s College School of Medicine and Dentistry, London, United Kingdom
    Cardiovasc Res 25:314-8. 1991
    ..Comparative investigations were made on anaerobic and aerobic skeletal muscles, and plasma insulin and growth hormone levels were also measured to see if these were mediating factors...
  101. ncbi Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes
    Lee K Landeen
    Department of Bioengineering, University of California, San Diego, La Jolla, California, USA
    Am J Physiol Heart Circ Physiol 294:H736-49. 2008
    ..This decrease in APD is expected to decrease Ca(2+) influx and reduce [Ca(2+)](i) and myocyte contractility...

Research Grants40

  1. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..This information will aid the development of newer and safer anesthetics, as well as lead to clinically useful means of modulating the neurotransmitter systems that are themselves modulated by anesthetics. ..
  2. ANESTHETIC EFFECTS ON SENSORIMOTOR INTEGRATION
    JOSEPH ANTOGNINI; Fiscal Year: 2009
    ..Understanding how and where anesthetics act will eventually lead to the development of better and safer anesthetics, thereby decreasing peri-operative morbidity and mortality and improving public health. ..
  3. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
    ..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
  4. Relationship between Bio and Psych Correlates of PTSD
    Rachel Yehuda; Fiscal Year: 2005
    ..abstract_text> ..
  5. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..abstract_text> ..
  6. Psychobiology of PTSD: A Decade of Progress
    Rachel Yehuda; Fiscal Year: 2005
    ..We also expect the conference to be attractive to educated lay individuals such as consumers, family members, advocates, and members of the press who are interested in tracking the development of knowledge in this area. ..
  7. RELAXIN FAMILY PEPTIDES AND HEPATIC FIBROSIS
    Robert Bennett; Fiscal Year: 2009
    ..The research proposed in this application may lead to targeted therapeutic strategies for the treatment of liver disease, a major health concern in the United States. ..
  8. Biology of Risk of PTSD in Holocaust Survivor Offspring
    Rachel Yehuda; Fiscal Year: 2006
    ..The subjects will be further subdivided so that there are 40 in each group with and without PTSD; half of each subgroup will have a current depressive disorder. Thus, we will recruit a total of 20 subjects in each of 12 subgroups. ..
  9. Triazine library as a novel microtubule regulatory
    Young Tae Chang; Fiscal Year: 2006
    ..3) Rational design of a stronger tubulin binder and to identify other cellular targets of tubulyzine. ..
  10. Neurophysiologic Development Responses to Surgery
    DOUGLAS RIRIE; Fiscal Year: 2007
    ..Through this and future studies which come from this data and training, improvement in understanding will hopefully lead to improved pain therapy that is developmentally appropriate. ..
  11. MELATONIN FOR AGE-RELATED SLEEP DISTURBANCE IN WOMEN
    Patricia Murphy; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  12. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  13. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  14. Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    Philip E Bickler; Fiscal Year: 2010
    ..The work will also identify why the aging brain may not be able to benefit from the neuroprotective actions of anesthetics or other preconditioning treatments. ..
  15. CONSTRUCTION OF BIOLOGY RESEARCH FACILITY
    DIPAK SARKAR; Fiscal Year: 2002
    ..abstract_text> ..
  16. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..The proposed series of studies should enhance our knowledge of the physiological mechanisms orchestrating NK cell circadian function. ..
  17. SEX HORMONES SLEEP AND CIRCADIAN RHYTHMICITY IN AGING
    Patricia Murphy; Fiscal Year: 2002
    ....
  18. Fas-Induced Apoptosis and Inflammatory Lung Injury
    Yon Rojanasakul; Fiscal Year: 2003
    ..We expect that the proposed studies will provide valuable new information on the molecular mechanisms of Fas induced apoptosis and its role in lung pathogenesis. ..
  19. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  20. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2003
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  21. PROLACTIN EFFECTS ON BEHAVIOR
    JOHN BUNTIN; Fiscal Year: 2004
    ....
  22. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  23. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  24. PROLACTIN EFFECTS ON BEHAVIOR: SITES AND MODES OF ACTION
    JOHN BUNTIN; Fiscal Year: 2007
    ..They may also shed light on the causes of infertility in nursing women with elevated PRL secretion and in men and women with PRL-secreting pituitary tumors. [unreadable] [unreadable] [unreadable]..
  25. Regulation of Fas-Mediated Lung Cell Apoptosis
    Yon Rojanasakul; Fiscal Year: 2009
    ..abstract_text> ..
  26. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  27. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..This information should help to develop therapeutic strategies in managing sleep-wake disturbances and the resultant health consequences in FAE offspring. ..
  28. Genetics, Endocrinology and PTSD Risk in the Population
    Rachel Yehuda; Fiscal Year: 2006
    ..The development of models of prevention and treatment of PTSD can only occur following an understanding of individual risk factors and their interactions with event exposure. ..
  29. Estrogen Induced Neuroplasticity in the Lordosis Pathway
    LORI FLANAGAN CATO; Fiscal Year: 2004
    ..The results of these studies may illuminate the effects of estrogen on neural function. ..
  30. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
    ..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
  31. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  32. Thymosin beta 4 and Autoimmune Ocular Surface Disease
    Gabriel Sosne; Fiscal Year: 2004
    ..abstract_text> ..
  33. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  34. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
    ....
  35. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ....
  36. ESTROGEN MITOGENIC ACTION IN THE PITUITARY
    DIPAK SARKAR; Fiscal Year: 2003
    ..Such knowledge should be important in understanding prolactinoma because increased proliferation is an early step in cell transformation. ..
  37. Thymosin beta 4 and Corneal Wound Healing
    Gabriel Sosne; Fiscal Year: 2005
    ..abstract_text> ..
  38. Retinal drive of spontaneous system activity
    MATTHEW COLONNESE; Fiscal Year: 2008
    ..This information will aid in the development of accurate models of activity dependent development. ..
  39. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  40. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..