Summary: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer DATABASES, and gene and protein structure function analysis and prediction.

Top Publications

  1. pmc Microbial cellulose utilization: fundamentals and biotechnology
    Lee R Lynd
    Chemical and Biochemical Engineering, Thayer School of Engineering and Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Microbiol Mol Biol Rev 66:506-77, table of contents. 2002
  2. ncbi Hydrolysis of lignocellulosic materials for ethanol production: a review
    Ye Sun
    Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh 27695 7625, USA
    Bioresour Technol 83:1-11. 2002
  3. pmc De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology
    Jurgen F Nijkamp
    The Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands
    Microb Cell Fact 11:36. 2012
  4. ncbi The path forward for biofuels and biomaterials
    Arthur J Ragauskas
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Science 311:484-9. 2006
  5. ncbi Human protein reference database and human proteinpedia as discovery resources for molecular biotechnology
    Renu Goel
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
    Mol Biotechnol 48:87-95. 2011
  6. ncbi Commercial applications of microalgae
    Pauline Spolaore
    Laboratoire de Génie des Procédés et Matériaux, Ecole Centrale Paris, 92295 Chatenay Malabry Cedex, France
    J Biosci Bioeng 101:87-96. 2006
  7. ncbi Valuable products from biotechnology of microalgae
    Otto Pulz
    IGV Institut für Getreideverarbeitung GmbH, Arthur Scheunert Allee 40 41, 14558 Nuthetal, Germany
    Appl Microbiol Biotechnol 65:635-48. 2004
  8. pmc Progress in metabolic engineering of Saccharomyces cerevisiae
    Elke Nevoigt
    Department of Microbiology and Genetics, Berlin University of Technology, Seestr 13, 13353 Berlin, Germany
    Microbiol Mol Biol Rev 72:379-412. 2008
  9. pmc Metagenomics: application of genomics to uncultured microorganisms
    Jo Handelsman
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Microbiol Mol Biol Rev 68:669-85. 2004
  10. ncbi CHO cells in biotechnology for production of recombinant proteins: current state and further potential
    Jee Yon Kim
    Department of Biological Sciences, Graduate School of Nanoscience and Technology WCU, KAIST, 373 1 Kusong Dong, Yuseong Gu, Daejeon 305 701, Korea
    Appl Microbiol Biotechnol 93:917-30. 2012

Detail Information

Publications369 found, 100 shown here

  1. pmc Microbial cellulose utilization: fundamentals and biotechnology
    Lee R Lynd
    Chemical and Biochemical Engineering, Thayer School of Engineering and Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Microbiol Mol Biol Rev 66:506-77, table of contents. 2002
  2. ncbi Hydrolysis of lignocellulosic materials for ethanol production: a review
    Ye Sun
    Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh 27695 7625, USA
    Bioresour Technol 83:1-11. 2002
    ..Simultaneous saccharification and fermentation effectively removes glucose, which is an inhibitor to cellulase activity, thus increasing the yield and rate of cellulose hydrolysis...
  3. pmc De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology
    Jurgen F Nijkamp
    The Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands
    Microb Cell Fact 11:36. 2012
    ..The assembled sequence reveals that CEN.PK113-7D has a mosaic genome that combines characteristics of laboratory strains and wild-industrial strains...
  4. ncbi The path forward for biofuels and biomaterials
    Arthur J Ragauskas
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Science 311:484-9. 2006
    ..Advances in genetics, biotechnology, process chemistry, and engineering are leading to a new manufacturing concept for converting renewable ..
  5. ncbi Human protein reference database and human proteinpedia as discovery resources for molecular biotechnology
    Renu Goel
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
    Mol Biotechnol 48:87-95. 2011
    In the recent years, research in molecular biotechnology has transformed from being small scale studies targeted at a single or a small set of molecule(s) into a combination of high throughput discovery platforms and extensive ..
  6. ncbi Commercial applications of microalgae
    Pauline Spolaore
    Laboratoire de Génie des Procédés et Matériaux, Ecole Centrale Paris, 92295 Chatenay Malabry Cedex, France
    J Biosci Bioeng 101:87-96. 2006
    ..However, microalgal biotechnology only really began to develop in the middle of the last century...
  7. ncbi Valuable products from biotechnology of microalgae
    Otto Pulz
    IGV Institut für Getreideverarbeitung GmbH, Arthur Scheunert Allee 40 41, 14558 Nuthetal, Germany
    Appl Microbiol Biotechnol 65:635-48. 2004
    The biotechnology of microalgae has gained considerable importance in recent decades. Applications range from simple biomass production for food and feed to valuable products for ecological applications...
  8. pmc Progress in metabolic engineering of Saccharomyces cerevisiae
    Elke Nevoigt
    Department of Microbiology and Genetics, Berlin University of Technology, Seestr 13, 13353 Berlin, Germany
    Microbiol Mol Biol Rev 72:379-412. 2008
    ..Recent examples of yeast metabolic engineering for food, beverage, and industrial biotechnology (bioethanol and bulk and fine chemicals) follow. S...
  9. pmc Metagenomics: application of genomics to uncultured microorganisms
    Jo Handelsman
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Microbiol Mol Biol Rev 68:669-85. 2004
    ..The application of metagenomic sequence information will facilitate the design of better culturing strategies to link genomic analysis with pure culture studies...
  10. ncbi CHO cells in biotechnology for production of recombinant proteins: current state and further potential
    Jee Yon Kim
    Department of Biological Sciences, Graduate School of Nanoscience and Technology WCU, KAIST, 373 1 Kusong Dong, Yuseong Gu, Daejeon 305 701, Korea
    Appl Microbiol Biotechnol 93:917-30. 2012
  11. ncbi An outlook on microalgal biofuels
    Rene H Wijffels
    Wageningen University, Bioprocess Engineering, Post Office Box 8129, 6700 EV Wageningen, Netherlands
    Science 329:796-9. 2010
  12. pmc Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnology
    Jacek Puchałka
    Synthetic and Systems Biology Group, Helmholtz Center for Infection Research HZI, Braunschweig, Germany
    PLoS Comput Biol 4:e1000210. 2008
    A cornerstone of biotechnology is the use of microorganisms for the efficient production of chemicals and the elimination of harmful waste...
  13. pmc Sponge-associated microorganisms: evolution, ecology, and biotechnological potential
    Michael W Taylor
    Department of Microbial Ecology, University of Vienna, Althanstr 14, A 1090 Vienna, Austria
    Microbiol Mol Biol Rev 71:295-347. 2007
    ..We review the status of this important field, outlining the various approaches (e.g., cultivation, cell separation, and metagenomics) which have been employed to access the chemical wealth of sponge-microbe associations...
  14. ncbi Metabolomics for functional genomics, systems biology, and biotechnology
    Kazuki Saito
    RIKEN Plant Science Center, Tsurumi ku, Yokohama, Japan
    Annu Rev Plant Biol 61:463-89. 2010
    Metabolomics now plays a significant role in fundamental plant biology and applied biotechnology. Plants collectively produce a huge array of chemicals, far more than are produced by most other organisms; hence, metabolomics is of great ..
  15. ncbi Microbial biosurfactants production, applications and future potential
    Ibrahim M Banat
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK
    Appl Microbiol Biotechnol 87:427-44. 2010
    ..In this paper, we review the current knowledge and the latest advances in biosurfactant applications and the biotechnological strategies being developed for improving production processes and future potential...
  16. ncbi Programming cells by multiplex genome engineering and accelerated evolution
    Harris H Wang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 460:894-8. 2009
    ..Our multiplex approach embraces engineering in the context of evolution by expediting the design and evolution of organisms with new and improved properties...
  17. ncbi Protein promiscuity and its implications for biotechnology
    Irene Nobeli
    Institute of Structural and Molecular Biology, School of Crystallography, Birkbeck, University of London, Malet Street, London, WC1E 7HX, UK
    Nat Biotechnol 27:157-67. 2009
    ..understanding of molecular recognition and how protein function has evolved over time but also in the realm of biotechnology. Understanding protein promiscuity is becoming increasingly important not only to optimize protein engineering ..
  18. ncbi Ecology and biotechnology of the genus Shewanella
    Heidi H Hau
    Department of Microbiology and The BioTechnology Institute, University of Minnesota, St Paul, Minnesota 55108, USA
    Annu Rev Microbiol 61:237-58. 2007
    ..The ecology and biotechnology of these organisms are intertwined, with genomics playing a key role in our understanding of their physiology.
  19. ncbi The Corynebacterium glutamicum genome: features and impacts on biotechnological processes
    M Ikeda
    Tokyo Research Laboratories, Kyowa Hakko Kogyo, Asahi machi, Machida, 194 8533, Tokyo, Japan
    Appl Microbiol Biotechnol 62:99-109. 2003
    ..How can traditional fermentation benefit from the C. glutamicum genomic data? The path from genomics to biotechnological processes is presented...
  20. ncbi Microbial fuel cells: novel biotechnology for energy generation
    Korneel Rabaey
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Trends Biotechnol 23:291-8. 2005
    ..Here we discuss how bacteria use an anode as an electron acceptor and to what extent they generate electrical output. The MFC technology is evaluated relative to current alternatives for energy generation...
  21. ncbi The ecology and biotechnology of sulphate-reducing bacteria
    Gerard Muyzer
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Nat Rev Microbiol 6:441-54. 2008
    ..Although SRB have been studied for more than a century, it is only with the recent emergence of new molecular biological and genomic techniques that we have begun to obtain detailed information on their way of life...
  22. ncbi Lipases for biotechnology
    Karl Erich Jaeger
    Institute for Molecular Enzyme Technology, Heinrich Heine Universitat Dusseldorf, Forschungszentrum Julich, D 52425, Julich, Germany
    Curr Opin Biotechnol 13:390-7. 2002
    ..Furthermore, novel biotechnological applications have been successfully established using lipases for the synthesis of biopolymers and biodiesel, the production of enantiopure pharmaceuticals, agrochemicals, and flavour compounds...
  23. pmc Design and characterization of molecular tools for a Synthetic Biology approach towards developing cyanobacterial biotechnology
    Hsin Ho Huang
    Department of Photochemistry and Molecular Science, Angstrom Laboratories, Uppsala University, P O Box 523, SE 751 20 Uppsala, Sweden
    Nucleic Acids Res 38:2577-93. 2010
    ..strain PCC6803. The pPMQAK1 shuttle vector allows the use of the growing numbers of BioBrick parts in many prokaryotes, and the other tools herein implemented facilitate the development of new parts and systems in cyanobacteria...
  24. ncbi Consolidated bioprocessing of cellulosic biomass: an update
    Lee R Lynd
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Curr Opin Biotechnol 16:577-83. 2005
    ..Recent studies of the fundamental principles of microbial cellulose utilization support the feasibility of CBP...
  25. pmc Bacteriophages and their implications on future biotechnology: a review
    Irshad Ul Haq
    NUST Center of Virology and Immunology NCVI, National University of Sciences and Technology NUST, H 12, Islamabad 44000, Pakistan
    Virol J 9:9. 2012
    ..has been recognized that bacteriophages, the natural predators of bacteria can be used efficiently in modern biotechnology. They have been proposed as alternatives to antibiotics for many antibiotic resistant bacterial strains...
  26. pmc Alkaliphiles: some applications of their products for biotechnology
    K Horikoshi
    Japan Marine Science and Technology Center, Yokosuka, Kanagawa and Toyo University, Kawagoe, Japan
    Microbiol Mol Biol Rev 63:735-50, table of contents. 1999
    ..It has also been reported that alkali-treated wood pulp could be biologically bleached by xylanases produced by alkaliphiles. Other applications of various aspects of alkaliphiles are also discussed...
  27. ncbi Aromatic hydrocarbon dioxygenases in environmental biotechnology
    D T Gibson
    Department of Microbiology, The Center for Biocatalysis and Bioprocessing, The University of lowa, lowa City, IA 52242, USA
    Curr Opin Biotechnol 11:236-43. 2000
    ..These characteristics make them attractive synthons for the production of industrially and medically important chiral chemicals and also provide essential information for the development of bioremediation technology...
  28. ncbi Bio-mining the microbial treasures of the ocean: new natural products
    Johannes F Imhoff
    Kieler Wirkstoff Zentrum am Leibniz Institut für Meereswissenschaften IFM GEOMAR, Düsternbrooker Weg 20, 24105 Kiel, Germany
    Biotechnol Adv 29:468-82. 2011
    ..almost untouched capacity to produce natural products and therefore the importance of microbes for marine biotechnology was realized on a broad basis by the scientific communities only recently...
  29. ncbi Fat tissue: an underappreciated source of stem cells for biotechnology
    John K Fraser
    Cytori Therapeutics Inc, 3020 Callan Road, San Diego, CA 92121, USA
    Trends Biotechnol 24:150-4. 2006
    ..The combination of these properties, and the large quantity of cells that can be obtained from fat, suggests that this tissue will be a useful tool in biotechnology.
  30. ncbi Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products
    Anthony R Mire-Sluis
    Office of Biotechnology Products, Center for Drug Evaluation and Research, FDA, Rockville, MD 20852, USA
    J Immunol Methods 289:1-16. 2004
    ..Sections on assay performance parameters, including those that appear in regulatory guidances, are contained in this manuscript...
  31. ncbi Key strongylid nematodes of animals - Impact of next-generation transcriptomics on systems biology and biotechnology
    Cinzia Cantacessi
    Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia
    Biotechnol Adv 30:469-88. 2012
  32. ncbi Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae
    Rene H Wijffels
    Wageningen University, Bioprocess Engineering, AlgaePARC, P O Box 8129, Wageningen 6700 EV, The Netherlands
    Curr Opin Biotechnol 24:405-13. 2013
    ..Experimental outdoor pilots under containment for the production of genetically modified cyanobacteria and microalgae are in progress. For full scale production risks of release of genetically modified organisms need to be assessed...
  33. ncbi Microbial lipases form versatile tools for biotechnology
    K E Jaeger
    Lehrstuhl Biologie der Mikroorganismen, Ruhr Universitat, Bochum, Germany
    Trends Biotechnol 16:396-403. 1998
    ..They catalyse not only the hydrolysis but also the synthesis of long-chain acylglycerols. Important uses in biotechnology include their addition to detergents, the manufacture of food ingredients, pitch control in the pulp and paper ..
  34. ncbi Pichia anomala: cell physiology and biotechnology relative to other yeasts
    Graeme M Walker
    Yeast Research Group, School of Contemporary Sciences, University of Abertay Dundee, Bell Street, Dundee, DD1 1HG, Scotland, UK
    Antonie Van Leeuwenhoek 99:25-34. 2011
    ..We await further basic knowledge of P. anomala cell physiology and genetics prior to its fuller commercial exploitation, but the exciting biotechnological potential of this yeast is highlighted in this paper...
  35. ncbi Single-cell analysis in biotechnology, systems biology, and biocatalysis
    Frederik S O Fritzsch
    Single Cell Laboratory, Leibniz Institut für Analytische Wissenschaften ISAS e V, Dortmund, Germany
    Annu Rev Chem Biomol Eng 3:129-55. 2012
    ..Finally, we define present and future challenges for SCA and propose strategies to overcome current limitations...
  36. ncbi Expert and public perception of risk from biotechnology
    Lucia Savadori
    Dipartimento di Scienze della Cognizione e della Formazione, University of Trento, Italy
    Risk Anal 24:1289-99. 2004
    Risk perceptions of a series of biotechnology applications were examined in a public (nonexpert) sample and an expert sample. Compared with the experts, the public perceived all biotechnology applications as more risky...
  37. ncbi Electron shuttles in biotechnology
    Kazuya Watanabe
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba, Tokyo 153 8904, Japan
    Curr Opin Biotechnol 20:633-41. 2009 the microbial energy metabolism, thereby opening up new possibilities for the application of microbes to biotechnology processes...
  38. ncbi Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system
    Jens Schneider
    Genetics of Prokaryotes, Department of Biology and CeBiTec, Bielefeld University, P O Box 100131, 33501 Bielefeld, Germany
    Appl Microbiol Biotechnol 95:169-78. 2012
    ..The ornithine decarboxylase gene speC was expressed from this argF addiction plasmid ensuring stable putrescine production by the engineered C. glutamicum strain...
  39. ncbi LC-PUFA from photosynthetic microalgae: occurrence, biosynthesis, and prospects in biotechnology
    Inna Khozin-Goldberg
    The French Associates Institute for Dryland Agriculture and Biotechnologies, The Jacob Blaustein Institutes for Desert Research, Ben Gurion University of the Negev, Midreshet Ben Gurion 84990, Israel
    Appl Microbiol Biotechnol 91:905-15. 2011
  40. ncbi Transgenic animal production and animal biotechnology
    J M Robl
    Hematech Inc, Sioux Falls, SD 57106, USA
    Theriogenology 67:127-33. 2007
    ..It is now possible to not only readily make simple insertional genetic modifications, but also to accomplish, more complex, homozygous gene targeting and artificial chromosome transfer in livestock...
  41. ncbi Agricultural biotechnology for crop improvement in a variable climate: hope or hype?
    Rajeev K Varshney
    International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, India
    Trends Plant Sci 16:363-71. 2011
    ..Here, we review two key biotechnology approaches, molecular breeding and genetic engineering, and their integration with conventional breeding to ..
  42. ncbi Trends in biotechnological production of fuel ethanol from different feedstocks
    Oscar J Sánchez
    Department of Chemical Engineering, National University of Colombia at Manizales, Cra 27 No 64 60 Of F 505, Manizales, Caldas, Colombia
    Bioresour Technol 99:5270-95. 2008
    ..Finally, some concluding considerations on current research and future tendencies in the production of fuel ethanol regarding the pretreatment and biological conversion of the feedstocks are presented...
  43. ncbi Plants to power: bioenergy to fuel the future
    Joshua S Yuan
    Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA
    Trends Plant Sci 13:421-9. 2008
    ..Here, we review different platforms, crops, and biotechnology-based improvements for sustainable bioenergy...
  44. ncbi Roadmap for implementation of quality by design (QbD) for biotechnology products
    Anurag S Rathore
    Department of Chemical Engineering, Indian Institute of Technology, New Delhi, India
    Trends Biotechnol 27:546-53. 2009
    ..This article presents a roadmap for successful QbD implementation for therapeutic biotechnology products. The approach presented here is aligned with existing regulatory guidance documents...
  45. ncbi Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids
    Volker F Wendisch
    Institute of Molecular Microbiology and Biotechnology, Westfalian Wilhelms University Munster, 48149 Munster, Germany
    Curr Opin Microbiol 9:268-74. 2006
  46. ncbi Emerging Corynebacterium glutamicum systems biology
    Volker F Wendisch
    Institute of Biotechnology 1, Research Center Juelich, Germany
    J Biotechnol 124:74-92. 2006
    ..glutamicum. We will present current developments that advanced our insight into fundamental biology of C. glutamicum and that in the future will enable novel biotechnological applications for the improvement of amino acid production...
  47. ncbi Biotechnological production of amino acids and derivatives: current status and prospects
    Wolfgang Leuchtenberger
    Degussa Stiftung, Bennigsenplatz 1, Düsseldorf 40474, Germany
    Appl Microbiol Biotechnol 69:1-8. 2005
    ..Nutrition and health will continue to be the driving forces for exploiting the potential of microorganisms, and possibly also of suitable plants, to arrive at even more efficient processes for amino acid production...
  48. ncbi Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health
    Filippos Ververidis
    Laboratory of Plant Biochemistry and Biotechnology, Department of Plant Sciences, Technological Educational Institute of Crete, Heraklion, Crete, Greece
    Biotechnol J 2:1214-34. 2007
  49. ncbi Cold-adapted enzymes: from fundamentals to biotechnology
    C Gerday
    Laboratory of Biochemistry, Institute of Chemistry, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Trends Biotechnol 18:103-7. 2000
    ..The application of these enzymes offers considerable potential to the biotechnology industry, for example, in the detergent and food industries, for the production of fine chemicals and in ..
  50. ncbi The Catharanthus alkaloids: pharmacognosy and biotechnology
    Robert van der Heijden
    Division of Pharmacognosy, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, P O Box 9502, 2300 RA Leiden, The Netherlands
    Curr Med Chem 11:607-28. 2004
    ..roseus has already led to a broad scientific spin-off. It is clear that many interesting results can be expected when more genes become available...
  51. ncbi Melanin synthesis in microorganisms--biotechnological and medical aspects
    Przemyslaw M Plonka
    Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 53:429-43. 2006
    ..This review summarizes current views on melanogenesis in Pro- and Eukaryotic microorganisms in terms of their biotechnological and biomedical importance...
  52. ncbi Cyanobacterial genomics for ecology and biotechnology
    Wolfgang R Hess
    University of Freiburg, Schänzlestr 1, D 79104 Freiburg, Germany
    Curr Opin Microbiol 14:608-14. 2011
    ..explaining their relevance for primary production in many ecosystems and the increasing interest for biotechnology. At present, there are more than 60 cyanobacteria for which a total genome sequence is publicly available...
  53. ncbi Multiscale requirements for bioencapsulation in medicine and biotechnology
    Paul De Vos
    University Hospital Groningen, Section of Medical Biology, Transplantation Biology and Immunoendocrinology, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Biomaterials 30:2559-70. 2009
    ..For adequate reproducibility and for understanding variations in outcome of biocapsules it is advisable if not mandatory to include the characterization processes presented in this review in future studies...
  54. ncbi Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels
    Sung Kuk Lee
    Joint BioEnergy Institute, Emeryville, CA 95608, USA
    Curr Opin Biotechnol 19:556-63. 2008
  55. ncbi Bacteriophages and biotechnology: vaccines, gene therapy and antibacterials
    Jason R Clark
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK
    Trends Biotechnol 24:212-8. 2006
    In recent years it has been recognized that bacteriophages have several potential applications in the modern biotechnology industry: they have been proposed as delivery vehicles for protein and DNA vaccines; as gene therapy delivery ..
  56. ncbi Bacterial lipases: an overview of production, purification and biochemical properties
    R Gupta
    Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, 110 021 New Delhi, India
    Appl Microbiol Biotechnol 64:763-81. 2004
    ..The latest trend in lipase research is the development of novel and improved lipases through molecular approaches such as directed evolution and exploring natural communities by the metagenomic approach...
  57. pmc Accomplishments in genome-scale in silico modeling for industrial and medical biotechnology
    Caroline B Milne
    Institute for Genomic Biology, University of Illinois, Urbana, IL, USA
    Biotechnol J 4:1653-70. 2009
    ..Here, we review comprehensively the uses of such models in industrial and medical biotechnology, including biofuel generation, food production, and drug development...
  58. ncbi Biomass pretreatment: fundamentals toward application
    Valery B Agbor
    Department of Biosystems Engineering, University of Manitoba, E2 376 EITC Winnipeg, Manitoba, Canada R3T5V6
    Biotechnol Adv 29:675-85. 2011
    ..The advantages and disadvantages, and the potential for industrial applications of different pretreatment technologies are the highlights of this paper...
  59. ncbi Biotechnology and genetics of ergot alkaloids
    P Tudzynski
    Institut fur Botanik, Westfalische Wilhelms Universitat, Munster, Germany
    Appl Microbiol Biotechnol 57:593-605. 2001
    ..The biotechnology of ergot alkaloids has a long tradition, and efficient parasitic and submerse production processes have been ..
  60. pmc Genetic tool development for a new host for biotechnology, the thermotolerant bacterium Bacillus coagulans
    Ákos T Kovács
    Groningen Biomolecular Sciences and Biotechnology Institute, Department of Genetics, University of Groningen, Kerklaan 30, 9751 NN Haren, Netherlands
    Appl Environ Microbiol 76:4085-8. 2010
    ..Here, we present a targeted gene disruption system using the Cre-lox system, development of a LacZ reporter assay for monitoring gene transcription, and heterologous d-lactate dehydrogenase expression...
  61. ncbi Biotechnological strategies to overcome inhibitors in lignocellulose hydrolysates for ethanol production: review
    W Parawira
    Department of Applied Biology, Kigali Institute of Science and Technology, Avenue de I Armee, B P 3900 Kigali, Rwanda
    Crit Rev Biotechnol 31:20-31. 2011
    ..A combination of more inhibitor-tolerant yeast strains with efficient feed strategies such as fed-batch will likely improve lignocellulose-to-ethanol process robustness...
  62. ncbi Industrial biotechnology: tools and applications
    Weng Lin Tang
    Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biotechnol J 4:1725-39. 2009
    Industrial biotechnology involves the use of enzymes and microorganisms to produce value-added chemicals from renewable sources...
  63. ncbi Improving iron, zinc and vitamin A nutrition through plant biotechnology
    Michael B Zimmermann
    Laboratory of Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, PO Box 474, CH 8803 Ruschlikon, Switzerland
    Curr Opin Biotechnol 13:142-5. 2002
    ..Improving the micronutrient composition of plant foods may become a sustainable strategy to combat deficiencies in human populations, replacing or complementing other strategies such as food fortification or nutrient supplementation...
  64. pmc Silkworm expression system as a platform technology in life science
    Tatsuya Kato
    Faculty of Agriculture, Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga ku, Shizuoka, Japan
    Appl Microbiol Biotechnol 85:459-70. 2010
    ..Silkworm biotechnology is an innovative and easy approach to achieve high protein expression levels and is a very promising platform ..
  65. ncbi Improvement of cellulase activity in Trichoderma reesei by heterologous expression of a beta-glucosidase gene from Penicillium decumbens
    Liang Ma
    Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Enzyme Microb Technol 49:366-71. 2011
    ..Our results indicated that the heterologous expression of a beta-glucosidase gene in T. reesei might produce balanced cellulase preparation...
  66. ncbi Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development
    Judith Becker
    Institute of Biochemical Engineering, Technische Universitat Braunschweig, Germany
    Curr Opin Biotechnol 23:718-26. 2012
    ..of more than four million tons per year, l-amino acids are among the most important products in industrial biotechnology. The recent years have seen a tremendous progress in the development of tailor-made strains for such products, ..
  67. ncbi Bispecific antibodies for cancer immunotherapy: Current perspectives
    Dafne Muller
    Institut fur Zellbiologie und Immunologie, Universitat Stuttgart, Germany
    BioDrugs 24:89-98. 2010
    ..This review summarizes recent progress in the development of bispecific antibodies and describes some new concepts developed for cancer immunotherapy...
  68. ncbi Bovine fetal microchimerism in normal and embryo transfer pregnancies and its implications for biotechnology applications in cattle
    Lauretta Turin
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita degli Studi di Milano, Milano, Italy
    Biotechnol J 2:486-91. 2007
  69. ncbi Haloalkane dehalogenases: biotechnological applications
    Tana Koudelakova
    Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment, Masaryk University, Brno, Czech Republic
    Biotechnol J 8:32-45. 2013
    ..Further extension of HLD uses within the field of biotechnology will require currently limiting factors - such as low expression, product inhibition, insufficient enzyme ..
  70. ncbi Chrysanthemum: advances in tissue culture, cryopreservation, postharvest technology, genetics and transgenic biotechnology
    Jaime A Teixeira da Silva
    Faculty of Agriculture, Kagawa University, Miki cho, Ikenobe 2393, Kagawa 761 0795, Japan
    Biotechnol Adv 21:715-66. 2003
    ..This review highlights all available literature that exists on ornamental Chrysanthemum in vitro cell, tissue and organ culture, micropropagation and transformation...
  71. ncbi Metabolic engineering applications to renewable resource utilization
    A Aristidou
    VTT Biotechnology, PO Box 1500, VTT ESPOO, 02044, Finland
    Curr Opin Biotechnol 11:187-98. 2000
    ..The metabolic engineering objectives so far have focused on higher yields, productivities and expanding the substrate and product spectra...
  72. ncbi Computer-aided biotechnology: from immuno-informatics to reverse vaccinology
    Sandro Vivona
    Molecular Biology and Bioinformatics Unit, Department of Biology, University of Padua, Padua, Italy
    Trends Biotechnol 26:190-200. 2008
    ..This will herald a move to 'computer-aided biotechnology': smart projects in which time-consuming and expensive large-scale experimental approaches are progressively ..
  73. ncbi The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption
    Gemma Farre
    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, Av Alcade Rovira Roure, Lleida, Spain
    Curr Opin Plant Biol 13:219-25. 2010
    ..However, this potential will not be realized if the major barriers to adoption - which are political rather than technical - are not overcome...
  74. ncbi Biophotonics and biotechnology in pancreatic cancer: cyclic RGD-peptide-conjugated type II quantum dots for in vivo imaging
    Ken Tye Yong
    Institute for Lasers, Photonics and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY, USA
    Pancreatology 10:553-64. 2010
    ..These studies support further evaluation of type II QDs as potential probes for early pancreatic cancer assessment and detection...
  75. pmc Plastid biotechnology for crop production: present status and future perspectives
    Jihong Liu Clarke
    Plant Health and Protection Division, Bioforsk Norwegian Institute for Agricultural and Environmental Research, Hoegskoleveien 7, 1432 Aas, Norway
    Plant Mol Biol 76:211-20. 2011
    ..advantages including transgene containment, has made significant progress in the last two decades in various biotechnology applications including development of crops with high levels of resistance to insects, bacterial, fungal and ..
  76. pmc Database resources of the National Center for Biotechnology
    David L Wheeler
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 31:28-33. 2003
    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made ..
  77. ncbi Biochemistry, physiology and biotechnology of sulfate-reducing bacteria
    Larry L Barton
    Department of Biology, University of New Mexico, MSCO3 2020, Albuquerque, New Mexico 87131, USA
    Adv Appl Microbiol 68:41-98. 2009
    ..Since SRB have displayed dissimilatory reduction of U(VI) and Cr(VI), several biotechnology procedures have been proposed for using SRB in bioremediation of toxic metals...
  78. ncbi New frontiers in oilseed biotechnology: meeting the global demand for vegetable oils for food, feed, biofuel, and industrial applications
    Chaofu Lu
    Department of Plant Sciences, Plant Pathology, Montana State University, Bozeman, MT 59717, USA
    Curr Opin Biotechnol 22:252-9. 2011
    ..b>Biotechnology offers a number of solutions to meet the growing need for affordable vegetable oils and vegetable oils with ..
  79. ncbi Control of protein immobilization: coupling immobilization and site-directed mutagenesis to improve biocatalyst or biosensor performance
    Karel Hernandez
    Departamento de Biocatalisis, Instituto de Catalisis CSIC, Campus UAM CSIC, Cantoblanco, 28049 Madrid, Spain
    Enzyme Microb Technol 48:107-22. 2011
    ..This paper intends to review some of the advances and possibilities that these coupled strategies permit...
  80. ncbi Root-targeted biotechnology to mediate hormonal signalling and improve crop stress tolerance
    Michel Edmond Ghanem
    Groupe de Recherche en Physiologie Végétale, Earth and Life Institute ELI A, Universite Catholique de Louvain, 1348, Louvain la Neuve, Belgium
    Plant Cell Rep 30:807-23. 2011
    ..Thus, root system engineering provides new opportunities to maintain sustainable crop production under changing environmental conditions...
  81. ncbi Advances in bacterial exopolysaccharides: from production to biotechnological applications
    Filomena Freitas
    REQUIMTE CQFB, Chemistry Department, FCT Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
    Trends Biotechnol 29:388-98. 2011
    ..Limitations and constraints of bacterial EPS development are stressed and correlation of bacterial EPS properties with polymer applications is emphasized...
  82. ncbi Research on orchid biology and biotechnology
    Yu Yun Hsiao
    Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan
    Plant Cell Physiol 52:1467-86. 2011
    ..and the current level of breeding technologies, basic research into orchid biology and the application of biotechnology in the orchid industry are continually endearing scientists to orchids in Taiwan...
  83. pmc Heterologous expression and extracellular secretion of cellulolytic enzymes by Zymomonas mobilis
    Jeffrey G Linger
    National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401, USA
    Appl Environ Microbiol 76:6360-9. 2010
    ..mobilis is capable of supporting the expression and secretion of high levels of cellulases relevant to biofuel production, thereby serving as a foundation for developing Z. mobilis into a CBP platform organism...
  84. ncbi Recent progress and new challenges in metagenomics for biotechnology
    Ludmila Chistoserdova
    Department of Chemical Engineering, University of Washington, Box 355014, Seattle, WA 98195, USA
    Biotechnol Lett 32:1351-9. 2010
  85. ncbi Mining metagenomes for novel cellulase genes
    Cheng Jie Duan
    Guangxi Key Laboratory of Subtropical Bioresource Conservation and Utilization, Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, and College of Life Science and Technology, Guangxi University, 100 Daxue Road, Nanning, Guangxi, 530004, People s Republic of China
    Biotechnol Lett 32:1765-75. 2010
    ..This review covers the current state of research and challenges in mining novel cellulase genes from the metagenomes of various environments, and discusses the potential biotechnological applications of metagenome-derived cellulases...
  86. ncbi Woody biomass pretreatment for cellulosic ethanol production: Technology and energy consumption evaluation
    J Y Zhu
    US Forest Service, Forest Products Laboratory, Madison, WI, USA
    Bioresour Technol 101:4992-5002. 2010
    ..Other important issues, such as the effects of lignin on substrate saccharification and the effects of pretreatment on high-value lignin utilization in woody biomass pretreatment, are also discussed...
  87. pmc Key process conditions for production of C(4) dicarboxylic acids in bioreactor batch cultures of an engineered Saccharomyces cerevisiae strain
    Rintze M Zelle
    Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, BC Delft, The Netherlands
    Appl Environ Microbiol 76:744-50. 2010
    ..Under optimized conditions, a malate yield of 0.48 +/- 0.01 mol (mol glucose)(-1) was obtained in bioreactors, a 19% increase over yields in shake flask experiments...
  88. ncbi Plant glycans: friend or foe in vaccine development?
    Dirk Bosch
    Wageningen University and Research Centre, The Netherlands
    Expert Rev Vaccines 9:835-42. 2010
    ..In this article, aspects of plant glycosylation and immunology are reviewed and we discuss the possibilities to use this knowledge for the rational design of plant-expressed vaccines...
  89. ncbi Hemicelluloses for fuel ethanol: A review
    F M Girio
    Laboratório Nacional de Energia e Geologia, I P, Unidade de Bioenergia, Estrada do Paco do Lumiar 22, 1649 038, Lisboa, Portugal
    Bioresour Technol 101:4775-800. 2010
    ..The recent trends, technical barriers and perspectives of future development are highlighted...
  90. ncbi Functional metagenomics for enzyme discovery: challenges to efficient screening
    Taku Uchiyama
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Curr Opin Biotechnol 20:616-22. 2009
    ..This review highlights recent studies on the screening of metagenomic libraries and discusses some possible solutions for overcoming the expression problem in function-based screening...
  91. ncbi Microalgae as bioreactors
    Tara L Walker
    Cluster for Molecular Biotechnology, Science Research Centre and CRC for Diagnostics, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4000, Australia
    Plant Cell Rep 24:629-41. 2005
    ..Nonetheless, several species can now be routinely transformed and algal biotechnology companies have begun to explore the possibilities of synthesizing recombinant therapeutic proteins in ..
  92. ncbi Potential of Aspergillus flavus genomics for applications in biotechnology
    Thomas E Cleveland
    United States Department of Agriculture, Agricultural Research Service USDA ARS, Southern Regional Research Center, 1100 Robert E Lee Blvd, New Orleans, LA 70124, USA
    Trends Biotechnol 27:151-7. 2009
    ..Analysis of putative secondary metabolism pathways might facilitate the discovery of new compounds with pharmaceutical properties, as well as new enzymes for biomass degradation...
  93. ncbi Systems biotechnology of mammalian cell factories
    Peter M O'Callaghan
    Department of Chemical and Process Engineering, University of Sheffield, Mappin St, Sheffield S1 3JD, UK
    Brief Funct Genomic Proteomic 7:95-110. 2008
    ..We also describe the use of high-throughput -omic technologies to investigate how mammalian cell factories respond to environmental and metabolic perturbation...
  94. ncbi Biotechnology and molecular biology of the alpha-glucosidase inhibitor acarbose
    U F Wehmeier
    Chemische Mikrobiologie, Bergische Universitaet Wuppertal, Gauss Strasse 20, 42097, Wuppertal, Germany
    Appl Microbiol Biotechnol 63:613-25. 2004
  95. ncbi Magnetoliposomes: versatile innovative nanocolloids for use in biotechnology and biomedicine
    Stefaan J H Soenen
    Interdisciplinary Research Centre, Laboratory of BioNanoColloids, KU Leuven Campus Kortrijk, E Sabbelaan 53, B 8500 Kortrijk, Belgium
    Nanomedicine (Lond) 4:177-91. 2009
    ..The goal of this article is not to list all known uses of magnetoliposomes but rather to present some conspicuous applications in comparison to other currently used nanoparticles...
  96. ncbi Towards new enzymes for biofuels: lessons from chitinase research
    Vincent G H Eijsink
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway
    Trends Biotechnol 26:228-35. 2008
    ..Furthermore, carefully selected substrate-disrupting accessory proteins or domains might provide novel tools to improve substrate accessibility and thus contribute to more efficient enzymatic processes...
  97. pmc Micro-algae come of age as a platform for recombinant protein production
    Elizabeth Specht
    San Diego Center for Algae Biotechnology, Department of Biological Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0368, USA
    Biotechnol Lett 32:1373-83. 2010
  98. ncbi Improving the flavor of fresh fruits: genomics, biochemistry, and biotechnology
    Harry J Klee
    University of Florida, Horticultural Sciences, PO Box 110690, Gainesville, FL 23611 0690, USA
    New Phytol 187:44-56. 2010
    ..However, our knowledge of the regulation of the critical metabolic pathways is still limited. Nonetheless, the pieces are in place for rapid advances to be made in the manipulation of flavor chemistry in the immediate future...
  99. ncbi Botryococcus braunii: a rich source for hydrocarbons and related ether lipids
    P Metzger
    Laboratoire de Chimie Bioorganique et Organique Physique, Ecole Nationale Superieure de Chimie de Paris, 11 rue Pierre et Marie Curie, 75231 Cedex 05 Paris, France
    Appl Microbiol Biotechnol 66:486-96. 2005
    ..This review covers the algal biodiversity, the chemical structures and biosynthesis of hydrocarbons and ether lipids and the biotechnological studies related to hydrocarbon production...
  100. pmc Microcalorimetry: a response to challenges in modern biotechnology
    Tino Krell
    Department of Environmental Protection, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, C Prof Albareda 1, 18008 Granada, Spain
    Microb Biotechnol 1:126-36. 2008
    ..problem-oriented applications of microcalorimetry and the solutions both techniques can provide to problems in biotechnology. The biotechnological issues to which microcalorimetry has been successfully applied are as diverse as ..
  101. ncbi Metabolic footprinting in microbiology: methods and applications in functional genomics and biotechnology
    Valeria Mapelli
    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE 412 96 Gothenburg, Sweden
    Trends Biotechnol 26:490-7. 2008
    ..Hereby, we state that integrative information from metabolic footprinting can assist in further interpretation of metabolic networks...

Research Grants74

  1. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..In this proposal, we have initiated a collaboration with the biotechnology company, Theralogics, to evaluate the use of TLX1001 licensed by the company in the prevention or treatment of ..
    Sarah Wagner; Fiscal Year: 2013
    ..g., misattributed paternity);the extent to which for-profit biotechnology companies have unique ethical obligations to victims and human rights organizations that contract their ..
  3. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011 endothelial cells, through collaboration of a university-based expert in cerebral IRI, and X-In8, a new biotechnology company with a novel concept about IRI...
  4. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..aureus vaccine is sorely needed. GlycoVaxyn, a small biotechnology firm in Switzerland, has developed a proprietary technology that enables the manufacture of bioconjugate ..
  5. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..Because of the pivotal role of ceramidases in regulating inflammation, Apogee Biotechnology Corporation is developing ceramidase inhibitors to treat inflammatory diseases...
  6. Roles of RNA Polymerases IV and V in siRNA-mediated gene silencing
    CRAIG STUART PIKAARD; Fiscal Year: 2013
    ..gene silencing using small RNA interference (RNAi) technologies are being used in medical and agricultural biotechnology applications...
  7. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    ..The applicant organization is TheraLogics, Inc., a small North Carolina based biotechnology company. The Principal Investigator on this application is Scott E...
  8. Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
    Eve Donnelly; Fiscal Year: 2013
    ..At RPI Dr. Vashishth has 1400 ft2 of lab space in the Center for Biotechnology and Interdisciplinary studies, a complex with 31,250 ft2 of open lab space and 27,250 ft2 of core lab space, ..
  9. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
    ..To execute this proposal we have gathered the appropriate technology, the commitment from the biotechnology industry, and the expertise and resources of the DM1 scientific and patient advocacy community...
  10. Optimal Selective Thyroid Hormone Analogs for Metabolic Syndrome
    John D Baxter; Fiscal Year: 2010
    ..modulators (STRMs) to safely elicit beneficial effects of TH excess states without harmful effects and several biotechnology companies have created compounds based on these principles...
  11. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..robust immunity to live alongside many bacteria, and indeed to use bacteria in processes from cheese-making to biotechnology, but under adverse conditions, bacteria are responsible for many important infectious diseases such as ..
  12. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..robust immunity to live alongside many bacteria, and indeed to use bacteria in processes from cheese-making to biotechnology, but under adverse conditions, bacteria are responsible for many important infectious diseases such as ..
  13. Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosis
    Joao A Paulo; Fiscal Year: 2013
    ..and industry and his former post-docs and students have acquired positions at high-ranking universities and biotechnology/pharmaceutical companies. As a member of Dr...
  14. Translational Immunology Research and Accelerated [vaccine] Development (TRIAD)
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    ..TRIAD, or the Translational Immunology Research and Accelerated [Vaccine] Development program, based in the Biotechnology Program at the University of Rhode Island, has pioneered the development and application of an integrated "..
  15. Live cell imaging of IgH and c-Myc gene loci and the role of nuclear organization
    Mark T Groudine; Fiscal Year: 2010
    ..of equipment, support core services at the Fred Hutchinson Cancer Center, and employ the services of external biotechnology companies...
  16. International Conf on Alzheimer Disease and Related Disorders in the Middle East
    Changiz Geula; Fiscal Year: 2013
    ..scientists, nurses, social workers, government representatives and other agencies, pharmaceutical and other biotechnology companies will attend the meeting to be held in Istanbul, Turkey, March 23-24, 2013...
  17. Nanodiagnostics and Nanotherapeutics: Building Research Ethics and Oversight
    Susan M Wolf; Fiscal Year: 2010
    ..the ethics of human subjects nanomedicine research;(2) an assessment of how NIH (including the Office of Biotechnology Activities (OBA) and the Recombinant DNA Advisory Committee (RAC)), FDA, and OHRP are approaching the ..
  18. Transferrin Conjugates for Oral Protein Drug Delivery
    Wei Chiang Shen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Due to the advancement of molecular biology and biotechnology, proteins and peptides are an increasingly important category of therapeutic drugs...
  19. HIV/NeuroAIDS Patient Derived Induced Pluripotent Stem (iPS) Cells
    Rodney J Nash; Fiscal Year: 2012
    ..high- throughput in vitro analysis in first phase drug discovery and preclinical product development in the biotechnology and pharmaceutical industry...
  20. FAMU RCMI Pharmaceutical Research Center
    Karam F A Soliman; Fiscal Year: 2013
    ..The RRC includes a: (1) Biotechnology Research Investigational Core providing services in proteomics;(peptide sequencing, protein identification, ..
    Anne I Sperling; Fiscal Year: 2013 translational medicine to speed improvement in human health, in research ethics to address advances in biotechnology and critical illness, and in nanomedicine to facilitate ultrastructural analyses and develop novel ..
  22. MRDD Research Center
    KARL PFENNINGER; Fiscal Year: 2009
    ..An adjacent biotechnology park will facilitate the translation of Center findings into treatments...
  23. Translating a CSF delivered AAV9-SMN for treatment of Spinal Muscular Atrophy
    Brian K Kaspar; Fiscal Year: 2013
    ..This work was published in Nature Biotechnology in 20109,10 as well as similar reports 11-13...
  24. Mechanisms of Virus Replication and Gene Expression
    ANNE ELIZABETH SIMON; Fiscal Year: 2013
    ..of Cell Biology and Molecular Genetics, Maryland-Virginia Regional Vet Medicine, University of Maryland Biotechnology Institute Center for Biosystems Research, NIH, NCI, and USDA...
  25. Recombinant Antibodies from the Sea Lamprey
    ZEEV contact PANCER; Fiscal Year: 2010
    ..VLRs are thus ideal candidates to serve as non-Ig single chain antibodies in biotechnology. We have developed a high-throughput platform for the selection of recombinant antigen-binding VLRs from large ..
  26. Obesity and Asthma: Genetics and Nutrigenetic Response to Omega-3 Fatty Acids
    Jason E Lang; Fiscal Year: 2013
    ..samples on the database of Genotypes and Phenotypes (dbGaP) maintained by National Center for Biotechnology Information...
    Marlene Belfort; Fiscal Year: 2013
    ..for their molecular mechanisms, phylogentic diversity, role in genome evolution, and application in research, biotechnology and medicine...
  28. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald L Jarvis; Fiscal Year: 2010
    ..It also could be used in the biotechnology industry to produce recombinant glycoproteins for clinical use as vaccines or therapeutics...
  29. Long-acting EPO analog for treating anemia associated with chronic kidney disease
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Bolder BioTechnology has created a highly potent, long-acting EPO analog that has a significantly increased circulating half-life ..
  30. Proteomics of Cell Death via 2-D Microfluidic Profiling
    DON DEVOE; Fiscal Year: 2009
    ..Dr. Baehrecke (Univ. of Maryland Biotechnology Institute) will lead the investigation of the programmed cell death studies, and analysis of the resulting ..
  31. CellTrap: A novel solid phase platform for analysis of stem/progenitor cells
    NICANOR I contact MOLDOVAN; Fiscal Year: 2010
    ..may enable the formation of a start-up company, creating additional employment opportunities relating to biotechnology, material sciences and administration...
  32. Development of mutant selective EGFR kinase inhibitors against EGFR T790M
    John Chant; Fiscal Year: 2010
    ..To overcome the T790M resistance mutation, the pharmaceutical and biotechnology industries have focused on developing a new class of EGFR inhibitors that irreversibly bind EGFR and have the ..
  33. FAH-Deficient Pigs
    Scott L Nyberg; Fiscal Year: 2011
    ..combined with immune modulation has been used to produce mice with humanized livers (Azuma 2007 Nature Biotechnology;Bissig 2010 J Clinical Investigation)...
  34. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    ..X-In8 is a biotechnology company whose mission is to develop strategies to temporarily turn off innate immunity to prevent IRI...
    JOHN PATRICK SHEEHAN; Fiscal Year: 2012
    ..Six are successful academic researchers, two are active researchers in biotechnology companies (including a Director of Research), and one is in medical school...
  36. Translational Optimization of Bone Regeneration in the Irradiated Mandible
    Steven R Buchman; Fiscal Year: 2013
    ..Advances in biotechnology have afforded a unique opportunity to innovate new remedies for XRT-induced side effects by bringing novel and ..
  37. Protein Therapeutics for Muscular Dystrophy
    Norio Takizawa; Fiscal Year: 2013 translate these basic science findings into therapeutic interventions for human diseases, we have formed a biotechnology company named TRIM-edicine, Inc, based on intellectual properties discovered at UMDNJ-Robert Wood Johnson ..
  38. Metabolic Engineering of Chinese Hamster Ovary Cells for Production of Heparin
    Susan T Sharfstein; Fiscal Year: 2011
    ..CHO cells are widely used in the biotechnology/biopharmaceutical industry for the production of recombinant therapeutic proteins...
  39. Optimization of Protein Therapeutics Formulations
    Lawrence J Delucas; Fiscal Year: 2012
    ..Pharmaceutical and biotechnology companies devote significant time and resources developing suitable formulations that allow the desired ..
  40. Metrics and tools for phenotyping sociality and development in animal models
    Jeffrey C Schank; Fiscal Year: 2011
    ..which will serve the mental health research community, including the laboratory, pharmaceutical, and biotechnology sectors...
    Radhakrishnan P Iyer; Fiscal Year: 2010
    ..There is great interest in the pharmaceutical and biotechnology industry to develop newer, safer antiviral drugs with novel mechanism of action that can be used in ..
  42. Developing Medications for Nicotine Cessation
    Selena E Bartlett; Fiscal Year: 2011
    ..of innovative treatments, and there is little interest in developing new treatments in the pharmaceutical and biotechnology industry...
  43. Foundations of Pretargeted Radioimmunotherapy
    KARL D WITTRUP; Fiscal Year: 2013
    ..Mathematical modeling and protein biotechnology are essential components of the project.
  44. Modifying Physical Activity and Sedentary Behavior via Mobile Phone Technology
    Abby C King; Fiscal Year: 2010
    ..According to the California Biomedical Industry, for every one employee of a biotechnology organization, another three to five will be employed in firms that service that industry...
  45. Inhibitors of disease-promoting activities of senescence
    DONALD PORTER; Fiscal Year: 2009
    ..Senex Biotechnology has identified a novel class of drug-like small molecules, SNX2-class compounds, which reduce the induction of ..
  46. Conference Support for International Congress on Oncogenic Herpesviruses
    Paul M Lieberman; Fiscal Year: 2012
    ..fees paid by conferees and contributions from host institutions, foundations, and pharmaceutical and biotechnology companies...
  47. Adipose-Derived Stromal/Stem Cell Therapy for Pressure Ulcers
    Xiying Wu; Fiscal Year: 2012
    ..LaCell LLC is a biotechnology company founded by leading investigators and inventors in the application of adipose stromal/stem cells to ..
  48. Anti-biofilm agents for treating pulmonary infection in Cystic Fibrosis patients
    LAURA MICHELLE GUOGAS; Fiscal Year: 2011
    ..Ward Peterson, former Vice President of Research and Preclinical Development at Inspire Pharmaceuticals, a biotechnology company formerly focused on CF therapeutics. Agile co-founder Dr...
  49. Antibody immunotherapeutics for biodefense against Lassa virus
    Robert F Garry; Fiscal Year: 2013
    ..and immunologists at Tulane University and the University of Texas Medical Branch with scientists at Zalgen, a biotechnology company specialized in the development of immunotherapeutics, rapid diagnostics, and new vaccine platforms for ..
  50. DNA - DNA interactions with atomic detail
    Lois Pollack; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): DNA and RNA condensation is of broad interest in both biology and biotechnology. The in vivo packaging of these nucleic acids (NAs) enables the efficient storage of genetic information;strategies for ..
  51. Photo-inactivation of Leishmania for safe and effective delivery of surrogate vac
    Kwang Poo Chang; Fiscal Year: 2013
    ..Transgenic biotechnology is well-developed for these eukaryotic protozoa to express foreign proteins for vaccination...
  52. Neuroprotective Gene Therapy in the Brain of Senile Rats
    Rodolfo G Goya; Fiscal Year: 2010
    ..a feature encouraged by this PAR), encompassing the fields of neuroendocrinology, cognitive neuroscience and biotechnology. PUBLIC HEALTH RELEVANCE: The increase in life expectancy achieved by modern medicine has led to a progressive ..
    CHARLES DALE POULTER; Fiscal Year: 2013
    ..use this knowledge to study the biological properties of isoprenoid molecules and develop new applications for biotechnology. To facilitate this work we are developing a library of E...
  54. Advances in Optics for Biotechnology, Medicine and Surgery
    James W Tunnell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This proposal is requesting funds to support "Advances in Optics for Biotechnology, Medicine and Surgery", an interdisciplinary conference, optimally sized for cross-fertilization (~120 attendee), ..
  55. Biotechnology Training in Biomedical Sciences and Engineering
    Yi Tang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of the UCLA Biotechnology Training in Biomedical Science and Engineering (BTBSE) Program is to educate and to train the next generation of highly skilled scientists and engineers who will ..
  56. Oral Therapy for Hemophilia A
    Kam W Leong; Fiscal Year: 2013
    ..and has a much higher risk of inhibitor formation), we assembled an interdisciplinary team, encompassing plant biotechnology, bioengineering, immunology, and animal models...
  57. Hand-Held Infrared Scanner for Early Detection of Melanoma
    Cila Herman; Fiscal Year: 2013
    ..Intellectual property generated through these studies is expected to lead to a biotechnology startup company focused on infrared imaging of cutaneous lesions.
  58. Regulation of Intestinal Bile Acid Transport
    Waddah A Alrefai; Fiscal Year: 2013
    ..and determine the efficacy of the beneficial dietary compound EGCG and specific ASBT inhibitors (developed by Biotechnology Company Albireo) in lowering the levels of plasma cholesterol...
  59. N-Linked Protein Glycosylation: Pathways and Processes
    Barbara Imperiali; Fiscal Year: 2013
    ..N-linked glycosylation is also of great relevance in medicine and biotechnology, as protein therapeutics including monoclonal antibodies, glycoprotein hormones, and cytokines have become ..
  60. Isolation of functional IgGs in the cytoplasm of a novel E. coli expression host
    Mehmet Berkmen; Fiscal Year: 2011
    ..RELEVANCE: Monoclonal antibodies and antibody-based fragments account for >30% of all revenues in the biotechnology market and are used to treat a wide array of human diseases including asthma, autoimmune diseases, bacterial ..
  61. Development of novel immunotherapy for influenza virus infection
    Kazue Takahashi; Fiscal Year: 2011
    ..of Medicine at Beth Israel Deaconess Medical Center and the product development expertise of Enzon, a US biotechnology company that acquired rights to produce recombinant lectin chimeras...
  62. Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training Center
    Janet M Oliver; Fiscal Year: 2013 cancer cell and molecular biology research and, since the mid-90s, by increasingly strong contributions of biotechnology to our cancer research programs...
  63. Optimization of SWCNT/siRNA complex formulation for tumor accumulation
    Lynn Kirkpatrick; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ensysce Biosciences Inc. is a biotechnology company located in Houston, TX, exploiting the pionering nanotechnology studies of the late 1996 Nobel Laureate, Dr. Richard Smalley of Rice University...
  64. Superior Near-IR Dyes for Bioimaging
    ARUNKUMAR EASWARAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Optical imaging is an advanced technique to image biotechnology products like gels, sensors, and micro arrays. It is also used increasingly to monitor specific molecular pathways in animals...
  65. Bright and Stable Near-IR dyes for Bioimaging
    ARUNKUMAR EASWARAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Optical imaging is an advanced technique to image biotechnology products like gels, sensors, and micro arrays. It is also used increasingly to monitor specific molecular pathways in animals...
  66. Diagnostic Biomarkers for Radicular Pain
    GAETANO JOHN SCUDERI; Fiscal Year: 2010
    ..Cytonics Corporation is a privately held biotechnology company that has discovered a novel protein biomarker that not only identifies the source of radicular pain ..
  67. Designing Life: Stories from the Bioethical Frontier
    LAURIE DONNELLY; Fiscal Year: 2010
    ..whether a multi-platform media project can increase people's knowledge of the ethical implications of biotechnology's growing potential to alter lives and complicate healthcare decisions plus affect their awareness of and ..
    JOANNA GOLDBERG; Fiscal Year: 1999
    Pseudomonas 1999-Seventh International Congress on Pseudomonas: Biotechnology and Pathogenesis is to be held September 1-5, 1999 at the Hyatt Regency Maui, Hawaii...
  69. Using combinatorial control to improve transgene expression specificity in plants
    Tedd D Elich; Fiscal Year: 2012
    ..It is widely recognized that advances in agricultural biotechnology will be required to meet the world's future nutritional needs...
    Mildred Cho; Fiscal Year: 2002
    ..and other sequences discovered through the Human Genome Project and large-scale sequencing efforts by private biotechnology companies are being rapidly patented by non-profit academic and for-profit institutions...
    ALEXEY MARGOLIN; Fiscal Year: 2000
    ..of stable and efficient formulation of proteins for their use as drugs has been the major focus of several biotechnology and pharmaceutical companies...
  72. Optimization of Protein Therapeutic Formulations
    Lawrence J Delucas; Fiscal Year: 2010
    ..Pharmaceutical and biotechnology companies devote significant time and resources developing suitable formulations that allow the desired ..
  73. 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
    John J Stegeman; Fiscal Year: 2010
    ..graduate students and post-docs to attend the 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology. This meeting deals with aspects of evolution, structure, function, and application of cytochrome P450 genes ..
  74. NIH Biotechnologist: Authentic Exploration of Biotechnology in Health Science
    Steven Moore; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The proposed NIH Biotechnologist: Authentic Explorations of Biotechnology, Genetics, and Genomics in Health Science project will produce a model lesson-"Restriction Mapping: Mapping ..