linear energy transfer

Summary

Summary: Rate of energy dissipation along the path of charged particles. In radiobiology and health physics, exposure is measured in kiloelectron volts per micrometer of tissue (keV/micrometer T).

Top Publications

  1. ncbi Formation of clustered DNA damage after high-LET irradiation: a review
    Megumi Hada
    NASA Johnson Space Center, Houston, Texas 77058, USA
    J Radiat Res 49:203-10. 2008
  2. ncbi Charged particles in radiation oncology
    Marco Durante
    Gesellschaft fur Schwerionenforschung GSI, Helmholtzzentrum für Schwerionenforschung, Biophysics Department, Plackstrasse 1, Darmstadt, Germany
    Nat Rev Clin Oncol 7:37-43. 2010
  3. ncbi RBE for carbon track-segment irradiation in cell lines of differing repair capacity
    W K Weyrather
    Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Int J Radiat Biol 75:1357-64. 1999
  4. ncbi Modelling of the oxygen enhancement ratio for ion beam radiation therapy
    Tatiana Wenzl
    Department of Radiation Oncology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munich, Germany
    Phys Med Biol 56:3251-68. 2011
  5. ncbi Effects of radiation quality and oxygen on clustered DNA lesions and cell death
    Robert D Stewart
    Department of Radiation Oncology, University of Washington, Seattle, Washington 98195 6043, USA
    Radiat Res 176:587-602. 2011
  6. ncbi Dose- and LET-painting with particle therapy
    Niels Bassler
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 49:1170-6. 2010
  7. ncbi LET dependency of heavy-ion induced apoptosis in V79 cells
    M Aoki
    Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 41:163-75. 2000
  8. ncbi Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 161:648-55. 2004
  9. ncbi Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 48:251-8. 2000
  10. ncbi Radiation dosimetry and biophysical models of space radiation effects
    Francis A Cucinotta
    NASA Lyndon B Johnson Space Center, Houston, TX, USA
    Gravit Space Biol Bull 16:11-8. 2003

Detail Information

Publications253 found, 100 shown here

  1. ncbi Formation of clustered DNA damage after high-LET irradiation: a review
    Megumi Hada
    NASA Johnson Space Center, Houston, Texas 77058, USA
    J Radiat Res 49:203-10. 2008
    ..1)) These data provide the best estimate of human cancer risk over the dose range for low linear energy transfer (LET) radiations, such as X- or gamma-rays...
  2. ncbi Charged particles in radiation oncology
    Marco Durante
    Gesellschaft fur Schwerionenforschung GSI, Helmholtzzentrum für Schwerionenforschung, Biophysics Department, Plackstrasse 1, Darmstadt, Germany
    Nat Rev Clin Oncol 7:37-43. 2010
    ..This Review considers the present clinical results in the field, and identifies and discusses the research questions that have resulted with this technique...
  3. ncbi RBE for carbon track-segment irradiation in cell lines of differing repair capacity
    W K Weyrather
    Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Int J Radiat Biol 75:1357-64. 1999
    ..RBE values for cell inactivation at different survival levels were determined and the differences in the RBE-LET patterns were compared with the individual sensitivity to photon irradiation of the different cell lines...
  4. ncbi Modelling of the oxygen enhancement ratio for ion beam radiation therapy
    Tatiana Wenzl
    Department of Radiation Oncology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munich, Germany
    Phys Med Biol 56:3251-68. 2011
    ..It can be expressed by the oxygen enhancement ratio (OER), which decreases with increasing linear energy transfer (LET) suggesting a potential clinical advantage of high-LET radiotherapy with heavy ion beams compared to ..
  5. ncbi Effects of radiation quality and oxygen on clustered DNA lesions and cell death
    Robert D Stewart
    Department of Radiation Oncology, University of Washington, Seattle, Washington 98195 6043, USA
    Radiat Res 176:587-602. 2011
    ..For low-linear energy transfer (LET) radiations, cells irradiated under normoxic conditions sustain about 2...
  6. ncbi Dose- and LET-painting with particle therapy
    Niels Bassler
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 49:1170-6. 2010
    ..Consequently, treatment planning based on simultaneous dose and LET optimisation has a potential to achieve higher tumour control and/or reduced normal tissue control probability (NTCP)...
  7. ncbi LET dependency of heavy-ion induced apoptosis in V79 cells
    M Aoki
    Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 41:163-75. 2000
    ..13, and 0.24, respectively. A similar trend was found for the RBE values calculated from the initial slope for both apoptosis and reproductive death. These results strongly suggest that the target for both types of cell death is the same...
  8. ncbi Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 161:648-55. 2004
    ..The health effects of exposure to high-LET radiation in humans on prolonged space flights should remain a matter of concern...
  9. ncbi Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 48:251-8. 2000
    ..To investigate the change in the surviving fractions by fractionated-dose irradiations with carbon ions, based on the recovery of potentially lethal damage (PLDR) and the change of radiosensitivity by every fractionated-dose irradiation...
  10. ncbi Radiation dosimetry and biophysical models of space radiation effects
    Francis A Cucinotta
    NASA Lyndon B Johnson Space Center, Houston, TX, USA
    Gravit Space Biol Bull 16:11-8. 2003
    ..Physical measurements of space radiation include the absorbed dose, dose equivalent, and linear energy transfer (LET) spectra...
  11. pmc Accelerated hematopoietic toxicity by high energy (56)Fe radiation
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    Int J Radiat Biol 88:213-22. 2012
    ....
  12. ncbi Contribution of indirect action to radiation-induced mammalian cell inactivation: dependence on photon energy and heavy-ion LET
    Atsushi Ito
    Course of Energy Engineering, Department of Applied Science, School of Engineering, Tokai University, Hiratsuka shi, Kanagawa 259 1292, Japan
    Radiat Res 165:703-12. 2006
    ..4 keV to 1.25 MeV and for heavy ions over the linear energy transfer (LET) range from 20 keV/microm to 440 keV/microm by applying competition kinetics analysis using the OH ..
  13. ncbi 53BP1 and MDC1 foci formation in HT-1080 cells for low- and high-LET microbeam irradiations
    Marita Mosconi
    Physikalisch Technische Bundesanstalt PTB, Bundesallee 100, 38116, Braunschweig, Germany
    Radiat Environ Biophys 50:345-52. 2011
    ..Preliminary data for proton irradiations are shown and also these indicate a delay for 53BP1 versus MDC1...
  14. ncbi Recent advances in light ion radiation therapy
    Anders Brahme
    Department of Medical Radiation Physics, Karolinska Institute and Hospital, Box 260, SE 171 76 Stockholm, Sweden
    Int J Radiat Oncol Biol Phys 58:603-16. 2004
    ....
  15. ncbi Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
    Herman Suit
    Department of Radiation Oncology, Boston, MA, USA
    Radiother Oncol 95:3-22. 2010
    ..The principal differences are LET, low for (1)H and high for (12)C, and a narrower penumbra of (12)C beams. Were (12)C to yield a higher TCP for a defined NTCP than (1)H therapy, would LET, fractionation or penumbra width be the basis?..
  16. ncbi Biological imaging of heavy charged-particle tracks
    B Jakob
    Gesellschaft fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Radiat Res 159:676-84. 2003
    ..The results suggest that additional factors like compaction or confined movement of chromatin are responsible for the observed clustering of proteins...
  17. ncbi Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 169:437-46. 2008
    ..particles is more skewed toward multiply damaged sites or clustered DNA damage than damage induced by low-linear energy transfer (LET) X and gamma rays...
  18. pmc Curcumin regulates low-linear energy transfer γ-radiation-induced NFκB-dependent telomerase activity in human neuroblastoma cells
    Natarajan Aravindan
    Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Radiat Oncol Biol Phys 79:1206-15. 2011
    ..Accordingly, we investigated the effect of curcumin in inhibiting IR-induced NFκB-dependent hTERT transcription, TA, and cell survival in neuroblastoma cells...
  19. ncbi Dose response of gamma rays and iron nuclei for induction of chromosomal aberrations in normal and repair-deficient cell lines
    Kerry A George
    Wyle, Houston, Texas 77058, USA
    Radiat Res 171:752-63. 2009
    ..The differences found between AT and NBS cells at lower doses suggest important questions about the applicability of observations of radiation sensitivity at high doses to low-dose exposures...
  20. ncbi Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation
    Lian Xue
    School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou, China
    Mutat Res 670:15-23. 2009
    High linear energy transfer (LET) radiation shows different biological effects from low-LET radiation...
  21. pmc A stochastic model of DNA fragments rejoining
    Yongfeng Li
    Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, United States of America
    PLoS ONE 7:e44293. 2012
    ..Overall, our work suggests that inhibiting the Ku-dependent NHEJ may significantly contribute to the increased efficiency for cell death and mutation observed for high LET radiation...
  22. ncbi Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia
    Takashi Nakano
    Research Center Hospital of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Clin Cancer Res 12:2185-90. 2006
    High linear energy transfer (LET) particles are believed to decrease tumor radiation resistance originating from hypoxia. However, no proof of this effect has been provided by clinical trials and related clinical research...
  23. ncbi Complex exchanges are responsible for the increased effectiveness of C-ions compared to X-rays at the first post-irradiation mitosis
    Ryonfa Lee
    Biophysics Department, GSI Helmholtzzentrum fur Schwerionenforschung, Planckstrasse 1, 64291 Darmstadt, Germany
    Mutat Res 701:52-9. 2010
    The purpose of the present study was to investigate as to what extent differences in the linear energy transfer (LET) are reflected at the chromosomal level. For this study human lymphocytes were exposed to 9...
  24. ncbi M-FISH analysis of chromosome aberrations in human fibroblasts exposed to energetic iron ions in vitro
    H Wu
    Wyle Laboratories, Houston, TX 77058, USA
    Adv Space Res 31:1537-42. 2003
    ..After 0.7 Gy of Fe ions, most complex aberrations were found to involve three or four chromosomes, indicating this is the maximum number of chromosome domains traversed by a single Fe ion track...
  25. ncbi Relative sensitivities of repair-deficient mammalian cells for clonogenic survival after alpha-particle irradiation
    Mark A Hill
    MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, United Kingdom
    Radiat Res 162:667-76. 2004
    ....
  26. ncbi Biological characteristics of carbon-ion therapy
    Koichi Ando
    Medicine and Biology Division, Gunma University Heavy Ion Medical Center, Showa machi 3 39 22, Maebashi shi, Gunma, Japan
    Int J Radiat Biol 85:715-28. 2009
    Radiotherapy using charged and/or high-linear energy transfer (LET) particles has a long history, starting with proton beams up to now carbon-ions...
  27. ncbi Applications of amorphous track models in radiation biology
    F A Cucinotta
    NASA Johnson Space Center, Houston, TX 77058, USA
    Radiat Environ Biophys 38:81-92. 1999
    ....
  28. ncbi High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells
    Emiko Sekine
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi 263 8555, Japan
    Mutat Res 652:95-101. 2008
    ..possible chromosome break and repair process in normal human fibroblasts irradiated with low and high LET (linear energy transfer) heavy ion radiation using the modified premature chromosome condensation (PCC) technique utilizing ..
  29. ncbi Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Anagawa, Japan
    Int J Radiat Oncol Biol Phys 48:241-50. 2000
    ..biological effectiveness (RBE) values of various human cell lines for carbon-ion beams with 2 different linear energy transfer (LET) beams and to investigate the relationship between the cell-killing effect and the biophysical ..
  30. ncbi Differential effects of x-rays and high-energy 56Fe ions on human mesenchymal stem cells
    Kyle Kurpinski
    Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA
    Int J Radiat Oncol Biol Phys 73:869-77. 2009
    ..This study was designed to compare the biological effects of X-rays and of high-linear energy transfer (LET) (56)Fe ions on human mesenchymal stem cells (hMSC).
  31. ncbi Analytical description of the LET dependence of cell survival using the repairable-conditionally repairable damage model
    M Wedenberg
    Medical Radiation Physics, Department of Oncology Pathology, Karolinska Institutet and Stockholm University, SE 17176, Stockholm, Sweden
    Radiat Res 174:517-25. 2010
    ..radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered...
  32. ncbi Induction and quantification of gamma-H2AX foci following low and high LET-irradiation
    Emma L Leatherbarrow
    DNA Damage Group, Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire, UK
    Int J Radiat Biol 82:111-8. 2006
    ..cells and HF19 human fibroblast cells, using the phosphorylation of the histone protein H2AX (gamma-H2AX) as an indicator of DSB, exposed to low doses of either low linear energy transfer (LET) (60)Co gamma-rays or high LET a-particles.
  33. ncbi Accurate description of the cell survival and biological effect at low and high doses and LET's
    Anders Brahme
    Department of Medical Radiation Physics, Karolinska Institutet, Stockholm, Sweden
    J Radiat Res 52:389-407. 2011
    ..This applies even for radiation resistant tumors, at least when the goal is to maximize tumor cure with minimal adverse reactions in normal tissues...
  34. ncbi p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation
    Jarah A Meador
    Center for Radiological Research, Columbia University, New York, New York 10032, USA
    Radiat Res 175:689-99. 2011
    ..These results show that both high- and low-LET radiation exposure negatively regulate histone gene expression in human lymphoblastoid and colon cancer cell lines independent of p53 status...
  35. ncbi Gene expression changes in normal human skin fibroblasts induced by HZE-particle radiation
    Liang Hao Ding
    Lawrence Berkeley National Laboratory, Life Sciences Division, MS74R0157, Berkeley, California 94720, USA
    Radiat Res 164:523-6. 2005
    ..The results support our hypothesis since the number of genes that commonly changed after exposure to both radiations increased as a function of particle energy...
  36. ncbi Effect of carbon ion radiotherapy for sacral chordoma: results of Phase I-II and Phase II clinical trials
    Reiko Imai
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 77:1470-6. 2010
    ..To summarize the results of treatment for sacral chordoma in Phase I-II and Phase II carbon ion radiotherapy trials for bone and soft-tissue sarcomas...
  37. ncbi Targeted irradiation of Mammalian cells using a heavy-ion microprobe
    Markus Heiss
    Department of Materials Research, Gesellschaft fur Schwerionenforschung, 64291 Darmstadt, Germany
    Radiat Res 165:231-9. 2006
    ....
  38. ncbi Spectrum of complex DNA damages depends on the incident radiation
    Megumi Hada
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Radiat Res 165:223-30. 2006
    ..The yields (damages/Mbp Gy(-1)) of all damages decreased with increasing linear energy transfer (LET) of the radiation...
  39. ncbi Radiobiology with heavy charged particles: a historical review
    L D Skarsgard
    Department of Medical Biophysics, B C Cancer Research Centre, Vancouver, Canada
    Phys Med 14:1-19. 1998
    ..of the dependence of RBE (relative biological effectiveness) and OER (oxygen enhancement ratio) on LET (linear energy transfer) was that by Barendsen in the early 1960's; he irradiated cultured human kidney cells with deuterium and ..
  40. ncbi Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells
    Natarajan Aravindan
    OUPB 1430, Department of Radiation Oncology, College of Medicine, University of Oklahoma Health Sciences Center, 825 North East 10th Street, Oklahoma City, OK 73104, USA
    Mol Cell Biochem 310:167-79. 2008
    ..Serum-starved human SK-N-MC cells were exposed to low linear energy transfer (LET) radiation (2 Gy) and incubated for 15, 30, 45 min, and 48 h...
  41. ncbi Energy deposition stochastics and track structure: what about the target?
    Dudley T Goodhead
    MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxfordshire OX11 0RD, UK
    Radiat Prot Dosimetry 122:3-15. 2006
    ....
  42. ncbi Detection of oxidative stress induced by low- and high-linear energy transfer radiation in cultured human epithelial cells
    X Steven Wan
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 163:364-8. 2005
    ..lower slope values for the dose responses of HZE-particle radiation-induced DCFH oxidation indicate that the sensitivity of the DCF fluorometric assay is probably dependent on the linear energy transfer (LET) of the radiation beam.
  43. pmc Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation
    Hongyan Wang
    Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA
    Nucleic Acids Res 38:3245-51. 2010
    ..High-linear energy transfer (LET) IR (such as high energy charged particles) killing more cells at the same dose as compared with low-..
  44. pmc Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells
    Kurtis J Haro
    Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Blood 120:2087-97. 2012
    Low linear energy transfer (LET) ionizing radiation (IR) is an important form of therapy for acute leukemias administered externally or as radioimmunotherapy. IR is also a potential source of DNA damage...
  45. pmc Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications
    Tatiana Wenzl
    Department of Radiation Oncology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Str, 22, 81675 Munich, Germany
    Radiat Oncol 6:171. 2011
    ....
  46. ncbi RBE of carbon ions: experimental data and the strategy of RBE calculation for treatment planning
    W K Weyrather
    GSI Biophysik
    Radiother Oncol 73:S161-9. 2004
    ..In a theoretical approach, the local effect model (LEM), this dependence is used to calculate clinical RBE. Examples for clinical RBEs are given that have been applied to patient treatments...
  47. ncbi Comparison of cellular lethality in DNA repair-proficient or -deficient cell lines resulting from exposure to 70 MeV/n protons or 290 MeV/n carbon ions
    Stefan C Genet
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Oncol Rep 28:1591-6. 2012
    ..two charged particle treatment modalities with respect to modeled anatomical depth-dependent dose and linear energy transfer (LET) deliveries to cells with either normal or compromised DNA repair phenotypes...
  48. pmc Proteomics and pathway analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer cells
    Sara Ståhl
    Department of Oncology Pathology, Karolinska Biomics Center, Karolinska Institutet, S 17176 Stockholm, Sweden
    Mol Cell Proteomics 8:1117-29. 2009
    ..In this work, we show that high linear energy transfer (LET) IR induces apoptosis in a non-small cell lung cancer cell line, U-1810, whereas low LET IR does not...
  49. ncbi S-phase cells are more sensitive to high-linear energy transfer radiation
    Hongyan Wang
    Department of Radiation Oncology and Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Int J Radiat Oncol Biol Phys 74:1236-41. 2009
    S-phase cells are more resistant to low-linear energy transfer (LET) ionizing radiation (IR) than nonsynchronized and G(1)-phase cells, because both nonhomologous end-joining (NHEJ) and homologous recombination repair can repair DNA ..
  50. ncbi Transmissible and nontransmissible complex chromosome aberrations characterized by three-color and mFISH define a biomarker of exposure to high-LET alpha particles
    Rhona M Anderson
    MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxfordshire, United Kingdom OX4 2UG
    Radiat Res 159:40-8. 2003
    ....
  51. ncbi No evidence for a low linear energy transfer adaptive response in irradiated RKO cells
    M B Sowa
    Cell Biology and Biochemistry, Pacific Northwest National Laboratory, PO Box 999, MS J4 02, Richland, WA 99354, USA
    Radiat Prot Dosimetry 143:311-4. 2011
    ..We have conducted a study of the adaptive response following low-linear energy transfer exposures for human colon carcinoma cells and failed to observe adaption for the endpoints of clonogenic ..
  52. ncbi Effect of LET on the yield and quality of chromosomal damage in metaphase cells: a time-course study
    S Ritter
    Biophysik, Geselleschaft für Schwerionenforschung, Planckstr 1, 64291 Darmstadt, Germany
    Int J Radiat Biol 78:191-202. 2002
    To investigate further the effect of linear energy transfer (LET) on the yield and quality of aberrations at different post-irradiation sampling times.
  53. ncbi Increased complexity of radiation-induced chromosome aberrations consistent with a mechanism of sequential formation
    R M Anderson
    MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon, UK
    Cytogenet Genome Res 112:35-44. 2006
    ..blood lymphocytes (PBL) after exposure to low doses (mostly single particles) of densely ionising high-linear energy transfer (LET) alpha-particle radiation...
  54. ncbi Impact of radiation quality on the spectrum of induced chromosome exchange aberrations
    J J Boei
    MCG, Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Wassenaarseweg 72, PO Box 9503, 2300 RA Leiden, The Netherlands
    Int J Radiat Biol 77:847-57. 2001
    ..The present data after neutron exposure are compared with previously obtained data after X-irradiation...
  55. ncbi The analysis of the densely populated patterns of radiation-induced foci by a stochastic, Monte Carlo model of DNA double-strand breaks induction by heavy ions
    Artem L Ponomarev
    Universities Space Research Association USRA, Houston, TX, USA
    Int J Radiat Biol 86:507-15. 2010
    To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns.
  56. ncbi Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes
    Artem L Ponomarev
    USRA, Houston, Texas, USA
    Int J Radiat Biol 82:293-305. 2006
    To apply a polymer model of DNA damage induced by high-LET (linear energy transfer) radiation and determine the influence of chromosomal domains and loops on fragment length distribution.
  57. ncbi Track structure and DNA damage
    M Kramer
    Biophysik, Gesellschaft fur Schwerionenforschung mbH, Germany
    Adv Space Res 14:151-9. 1994
    ..The result of this calculation is compared to other models and used for a qualitative interpretation of the induction of DNA damage by particles...
  58. ncbi Relative biological effectiveness of high linear energy transfer α-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells
    Nicolaas A P Franken
    Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology LEXOR, Centre for Experimental Molecular Medicine, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Oncol Rep 27:769-74. 2012
    ..as cell death and formation of chromosome rearrangements is less clear, especially for high linear energy transfer (LET) radiation...
  59. ncbi Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u-1 C ions and 9.9 MeV u-1 Ni ions
    S Tenhumberg
    Biophysik, Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Int J Radiat Biol 83:501-13. 2007
    To investigate further the relationship between high linear energy transfer (LET) induced cell cycle arrests and the yield of chromosome aberrations observable in normal human fibroblasts at the first post-irradiation mitosis.
  60. ncbi Mutation induction in human lymphoid cells by energetic heavy ions
    A Kronenberg
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    Adv Space Res 14:339-46. 1994
    ..The action cross section for induction of hprt-deficient mutants by energetic Fe ions is more than 10-fold lower for lymphoblastoid cells than for fibroblasts...
  61. ncbi Clustered DNA damage induced by heavy ion particles
    Hiroaki Terato
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima, Japan
    Biol Sci Space 18:206-15. 2004
    ..In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage...
  62. ncbi Radiobiologic parameters and local effect model predictions for head-and-neck squamous cell carcinomas exposed to high linear energy transfer ions
    Michael Beuve
    IPNL, LIRIS, IN2P3, Universite Lyon 1, Villeurbanne, France
    Int J Radiat Oncol Biol Phys 71:635-42. 2008
    ..the radiobiologic parameters of head-and-neck squamous cell carcinomas (HNSCC) in response to ion irradiation with various linear energy transfer (LET) values and to evaluate the relevance of the local effect model (LEM) in HNSCC.
  63. ncbi Radiation quality dependence of DNA damage induction
    B Stenerlow
    Rudbeck Laboratory, Uppsala University, S 751 85 Uppsala, Sweden
    Radiat Prot Dosimetry 99:137-41. 2002
    ..micron-1). The amount of DNA less than 1.1 Mbp decreased with increasing linear energy transfer (LET) for all three ions...
  64. pmc Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Centre, Dallas, TX 75390, USA
    Nucleic Acids Res 39:5474-88. 2011
    ..Our data suggest that downregulation of multiple DNA repair pathway genes in differentiated cells renders them vulnerable to DSBs, promoting genome instability that may lead to carcinogenesis...
  65. ncbi Effects of iron ions, protons and X rays on human lens cell differentiation
    P Y Chang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Radiat Res 164:531-9. 2005
    ..A model of molecular and cellular events is proposed to account for precataractous changes in the human lens after exposure to low- or high-LET radiations...
  66. ncbi Induction and rejoining of DNA double-strand breaks in normal human skin fibroblasts after exposure to radiation of different linear energy transfer: possible roles of track structure and chromatin organization
    H Höglund
    Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, S 751 85 Uppsala, Sweden
    Radiat Res 155:818-25. 2001
    ..Differences in repair kinetics were also evident, with slower rejoining for increasing LET, and the initial nonrandom fragment distributions were still present after 1 h of repair...
  67. ncbi What is the clinically relevant relative biologic effectiveness? A warning for fractionated treatments with high linear energy transfer radiation
    Alexandru Daşu
    Department of Radiation Physics, Norrland University Hospital, Umea, Sweden
    Int J Radiat Oncol Biol Phys 70:867-74. 2008
    To study the clinically relevant relative biologic effectiveness (RBE) of fractionated treatments with high linear energy transfer (LET) radiation and to identify the important factors that might influence the transfer of tolerance and ..
  68. pmc Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model
    Rudranath Persaud
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 65:9876-82. 2005
    ..hybrid (A(L)) and Chinese hamster ovary (CHO) cells in multicellular clusters was used to investigate low linear energy transfer (LET) radiation-induced bystander genotoxicity...
  69. pmc The apparent increase in the {beta}-parameter of the linear quadratic model with increased linear energy transfer during fast neutron irradiation
    B Jones
    Gray Institute for Radiation Oncology and Biology, University of Oxford, Headington, UK
    Br J Radiol 83:433-6. 2010
    The issue of whether the beta-parameter of the linear quadratic model changes with linear energy transfer (LET) remains controversial...
  70. ncbi In vitro evaluation of combined temozolomide and radiotherapy using X  rays and high-linear energy transfer radiation for glioblastoma
    Lara Barazzuol
    Ion Beam Centre, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
    Radiat Res 177:651-62. 2012
    High-linear energy transfer radiation offers superior biophysical properties over conventional radiotherapy and may have a great potential for treating radioresistant tumors, such as glioblastoma...
  71. ncbi Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions
    Honglu Wu
    National Space Biomedical Research Institute, Baylor College of Medicine, NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 160:418-24. 2003
    ..After 0.7 Gy of iron ions, most complex aberrations were found to involve three or four chromosomes, which is a likely indication of the maximum number of chromosome domains traversed by a single iron-ion track...
  72. ncbi Spectrometry of linear energy transfer with track-etched detectors in carbon ion beams, MONO and SOBP
    K Pachnerová Brabcová
    Department of Radiation Dosimetry, Nuclear Physics Institute, AS CR, Prague, Czech Republic
    Radiat Prot Dosimetry 143:440-4. 2011
    ..Ltd--TD1 and Baryotrak. Spectra of linear energy transfer and depth-dose distributions were obtained. Besides, differences among PADCs are discussed.
  73. ncbi Direct response to proton beam linear energy transfer (LET) in a novel polymer gel dosimeter formulation
    O Lopatiuk-Tirpak
    MD Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Technol Cancer Res Treat 11:441-5. 2012
    b>Linear energy transfer (LET) of clinical proton beams is an important parameter influencing the biological effects of radiation...
  74. ncbi Live cell imaging of heavy-ion-induced radiation responses by beamline microscopy
    B Jakob
    Gesellschaft fur Schwerionenforschung, Biophysik, D 64291 Darmstadt, Germany
    Radiat Res 163:681-90. 2005
    ....
  75. pmc Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning
    Clemens Grassberger
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:1559-66. 2011
    To calculate the linear energy transfer (LET) distributions in patients undergoing proton therapy. These distributions can be used to identify areas of elevated or diminished biological effect...
  76. ncbi High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer model
    T M Behr
    Department of Nuclear Medicine, Georg August University, Gottingen, Germany
    Cancer Res 59:2635-43. 1999
    Recent studies suggest that radioimmunotherapy (RIT) with high-linear energy transfer (LET) radiation may have therapeutic advantages over conventional low-LET (e.g., beta-) emissions...
  77. ncbi Relative biological effectiveness (RBE) values for proton beam therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 53:407-21. 2002
    ..0-1.1...
  78. ncbi In vitro screening for synergism of high-linear energy transfer 213Bi-radiotherapy with other therapeutic agents for the treatment of B-cell chronic lymphocytic leukemia
    Katia Vandenbulcke
    Department of Radiopharmacy, Ghent University, Ghent, Belgium
    Cancer Biother Radiopharm 21:364-72. 2006
    ..The development of RIT with alpha-emitters is attractive, owing to the high (LET) nature and short path length of alpha particles allowing for higher tumor cell kill and lower toxicity to healthy tissues...
  79. ncbi High linear energy transfer carbon radiation effectively kills cultured glioma cells with either mutant or wild-type p53
    Y Iwadate
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Radiat Oncol Biol Phys 50:803-8. 2001
    ..We studied cytotoxic effects of high linear energy transfer (LET) carbon beams on glioma cell lines with either mutant or wild-type p53.
  80. ncbi A polymer, random walk model for the size-distribution of large DNA fragments after high linear energy transfer radiation
    A L Ponomarev
    NASA ISC, Houston, TX 77058, USA
    Radiat Environ Biophys 39:111-20. 2000
    ..Dose-response relations, linear at small doses of high linear energy transfer (LET) radiation, are obtained...
  81. ncbi Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles
    Hongzhen Li
    Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Oncol 31:537-44. 2007
    ..This model provides an opportunity to study the cellular and molecular alterations that occur in radiation carcinogenesis in human prostate cells...
  82. ncbi Microbeam developments and applications: a low linear energy transfer perspective
    Marianne Sowa Resat
    Chemistry and Physics of Complex Systems, Pacific Northwest National Laboratory, MS K8 88, 3335 Q Ave, Richland, WA 99352, USA
    Cancer Metastasis Rev 23:323-31. 2004
    ..there has been a significant increase in the number of centers having, or developing, both high- and low-linear energy transfer (LET) microbeams for radiobiological investigations...
  83. ncbi Biological factors influencing the RBE of neutrons: implications for their past, present and future use in radiotherapy
    R A Britten
    Department of Oncology, University of Alberta, and Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    Radiat Res 156:125-35. 2001
    ..In the future, fast-neutron therapy might be prescribed based upon the relative status of appropriate molecular parameters that have a differential impact upon radiosensitivity to photons compared to fast neutrons...
  84. ncbi Calculation of magnetic field-induced current densities for humans from EAS countertop activation/deactivation devices that use ferromagnetic cores
    Qingxiang Li
    Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA
    Phys Med Biol 50:373-85. 2005
    ..For the two considered EAS systems using excitation currents of 5000 A turns at 200 Hz, the maximum 1 cm2 area-averaged induced current densities in the CNS tissues are calculated and found to be less than the ICNIRP safety limits...
  85. ncbi Simulations of an accelerator-based shielding experiment using the particle and heavy-ion transport code system PHITS
    T Sato
    JAERI, Tokai mura, Japan
    Adv Space Res 35:208-13. 2005
    ..In this paper, we report simulations of an accelerator-based shielding experiment, in which a beam of 1 GeV/n Fe-ions has passed through thin slabs of polyethylene, Al, and Pb at an acceptance angle up to 4 degrees...
  86. ncbi Self-shielding effects in neutron spectra measurements for neutron capture therapy by means of activation foils
    Krzysztof Pytel
    Institute of Atomic Energy, 05 400 Otwock Swierk, Poland
    Radiat Prot Dosimetry 110:823-6. 2004
    ..The comparison of activation rates of diluted and non-diluted foils has demonstrated the correctness of the applied self-shielding model...
  87. ncbi Averaged particle dose conversion coefficients in air crew dosimetry
    V Mares
    University of Munich, Institute of Radiobiology, D 80336 Munich, Germany
    Radiat Prot Dosimetry 110:371-6. 2004
    ..They show a slight dependence on altitude, solar activity and location in the geomagnetic field...
  88. ncbi Dosimetric considerations on TEPC fluka-simulation and measurements
    S Rollet
    Austrian Research Centre Seibersdorf, A 2444 Seibersdorf, Austria
    Radiat Prot Dosimetry 110:833-7. 2004
    ..The agreement between the calculated results and the measurements carried out with different well-known sources is well demonstrated. Work is in progress in order to evaluate the response of the instrument in the cosmic ray environment...
  89. ncbi Specific absorbed fractions for internal photon emitters calculated for a tomographic model of a pregnant woman
    C Y Shi
    Nuclear Engineering and Engineering Physics Programs, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Health Phys 87:507-11. 2004
    ..The main reasons for the differences are due to the variation of mass, geometry, and organ distances, and they demonstrate the influence of more realistic body models on dose calculations...
  90. ncbi Dose-response relationships for radicals trapped in irradiated solids
    William H Nelson
    Department of Physics and Astronomy, Georgia State University, Atlanta, Georgia 30303, USA
    Radiat Res 163:673-80. 2005
    ..In addition, the description preserves the general properties of the widely used relationships. Finally, the expressions provide the possibility for estimating the average mass of the target...
  91. ncbi Microdosimetry of inhomogeneous radon progeny distributions in bronchial airways
    H Fakir
    Institut de Radioprotection et de Surete Nucleaire, DRPH SDI, B P no 17, F 92262 Fontenay aux Roses Cedex, France
    Radiat Prot Dosimetry 113:129-39. 2005
    ..The results obtained suggest that the hit frequency may be the primary physical parameter for alpha particles, supplemented by microdosimetric single event spectra, to be related to biological effects for chronic low level exposures...
  92. ncbi Measurements of neutron effective doses and attenuation lengths for shielding materials at the heavy-ion medical accelerator in Chiba
    Yoshikazu Kumamoto
    National Institute of Radiological Sciences, 4 9 1, Anagawa, Inaga Ward, Chiba City, Japan, 263 8555
    Health Phys 88:469-79. 2005
    ....
  93. ncbi Tumor induction in mice locally irradiated with carbon ions: a retrospective analysis
    Koichi Ando
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 46:185-90. 2005
    ..Neither dose fractionation nor linear energy transfer affected tumor induction for carbon ions and gamma rays...
  94. ncbi Monte Carlo modelling of energy deposition in trabecular bone
    J A Gersh
    Department of Physics, East Carolina University, Howell Science Complex, Greenville, NC 27858, USA
    Radiat Prot Dosimetry 122:549-50. 2006
    ..In both comparisons, our results show a close agreement with published methods...
  95. ncbi Comments on "Dose-response relationships for radicals trapped in irradiated solids" by W. H. Nelson (Radiat. Res. 163, 673-680, 2005)
    Jack A Simmons
    Radiat Res 165:621-2. 2006
  96. ncbi Lineal energy as a function of site size for HZE radiation
    X Wang
    Department of Nuclear Engineering, Texas A and M University, College Station, TX, USA
    Radiat Prot Dosimetry 122:367-8. 2006
    ..They suggest that measurements of energy deposition in different size sites can be used to characterise the velocity of the incident particle...
  97. ncbi Monitoring the irradiation field of 12C and 16O SOBP beams using positron emitters produced through projectile fragmentation reactions
    Taku Inaniwa
    Department of Energy Sciences, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8502, Japan
    Phys Med Biol 53:529-42. 2008
    ..The close agreement between the estimated and the measured distributions implied that the shape of the dose distribution in an irradiated target could be evaluated from the detected annihilation gamma-ray distribution...
  98. ncbi Simulation of secondary particle production and absorbed dose to tissue in light ion beams
    Irena Gudowska
    Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Box 260, S 171 76 Stockholm, Sweden
    Radiat Prot Dosimetry 116:301-6. 2005
    ..The comparison of calculated secondary particle production in the water and PMMA phantoms irradiated with helium and carbon ions shows satisfactory agreement with experimental data...
  99. ncbi Overview of secondary neutron production relevant to shielding in space
    L Heilbronn
    MS 74 197, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Radiat Prot Dosimetry 116:140-3. 2005
    ..Stopping target yields and cross section measurements conducted at particle accelerators using heavy ions with energies > 100 MeV per nucleon are discussed...
  100. ncbi HETC radiation transport code development for cosmic ray shielding applications in space
    L W Townsend
    Department of Nuclear Engineering, University of Tennessee, Knoxville, TN 37996 2300, USA
    Radiat Prot Dosimetry 116:135-9. 2005
    ..Also, initial results of code testing against available laboratory beam data for energetic heavy ions interacting in thick targets are presented...
  101. ncbi Shielding and fragmentation studies
    C Zeitlin
    Lawrence Berkeley National Laboratory, MS74 197, Berkeley, CA 94720, USA
    Radiat Prot Dosimetry 116:123-4. 2005
    ..Measurement without a target present gives an indication of the level of contamination of the primary beam, which is also important in radiobiology experiments...

Research Grants55

  1. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA HENRIQUES VICENTE; Fiscal Year: 2010
    ..which occurs when boron-10 nuclei localized within tumors capture low-energy neutrons to produce high linear energy transfer particles whose cytotoxic effects are confined to the cells in which the drug is retained...
  2. Development of lisinopril for post-exposure mitigation of late effects from a rad
    MEETHA M MEDHORA; Fiscal Year: 2013
    ..We will also test lisinopril for mitigation after exposure to single low- and high-linear energy transfer irradiation (X-rays, neutron-gamma rays), and to radiation in combination with full thickness skin wounds ..
  3. Innovative Biomarkers to Predict Radiation Lung Injury
    MEETHA M MEDHORA; Fiscal Year: 2013
    ..We will test our biomarkers with low (X-rays) and mixed (neutrons and gamma rays) linear energy transfer (LET) sources of radiation that resemble an A-bomb...
  4. INFORMATION RESOURCES FOR RADIATION SCIENCE
    THOMAS SEBASTIAN TENFORDE; Fiscal Year: 2010
    ....
  5. Peptide-targeted alpha-particle emitting phage for ovarian cancer therapy.
    Thomas P Quinn; Fiscal Year: 2013
    ..Alpha particles are helium 4He ions that result in high linear energy transfer (LET) upon emission, significantly higher than the LET of 2-particle emitting radionuclides or x-rays...
  6. Protection against radiation-induced damage to intestinal nutrient transport
    Roger Howell; Fiscal Year: 2009
    ..exposures may be delivered acutely or chronically, by external or internal sources, and by low- and high-linear energy transfer (LET) radiations...
  7. Targeted Molecular Nano-Irradiation Against a Malignant Glioma Biomarker
    Akiva Mintz; Fiscal Year: 2010
    ..Despite the ultra short reach, Auger emitting isotopes have a very high linear energy transfer (LET) coefficient, which is why they produce predominantly double stranded DNA breaks that are unlikely to ..
  8. Mechanisms for Radiation Damage to DNA: LET Effects
    MICHAEL DOUGLAS SEVILLA; Fiscal Year: 2013
    ..and thereby elucidate fundamental mechanisms of radiation damage to DNA by radiations of varying linear energy transfer (LET)...
  9. INTERSTITIAL NEUTRON THERAPY FOR GLIOBLASTOMA
    ALFRED YOUNG; Fiscal Year: 1991
    ..Neutron radiation, which irradiates with high linear energy transfer (LET) radiation, has theoretical advantages over conventional low LET photon (x- ray) therapy, including: ..
  10. RADON, BRONCHIAL MORPHOMETRY, AND OCCUPATIONAL HEALTH
    David Brenner; Fiscal Year: 1993
    ..previously-collected biological data to quantify how the relative biological hazard varies with LET (Linear Energy Transfer, or stopping power, dE/dx) and its microdosimetric correlate, lineal energy...
  11. A Phase II Trial for Neutron Capture Therapy in Melanoma
    Paul Busse; Fiscal Year: 2003
    ..by applicant): Neutron capture therapy (NCT) is a unique form of radiation due to the combination of high linear energy transfer (LET) properties and biological targeting...
  12. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    John Sampson; Fiscal Year: 2004
    ..might be improved through the use of human chimeric MAbs with increased biostability and the use of high linear energy transfer radioisotopes, such as (211)At, with greater relative biological effectiveness...
  13. ROLES OF HUMAN RECOMBINATION GENES IN GENOME INSTABILITY
    David Chen; Fiscal Year: 2001
    ..Limited studies with alpha particles have also suggested that high linear energy transfer (LET) radiation is more potent than low LET gamma rays as an inducer of heritable genome instability...
  14. Phase I / II Trial for Neutron Capture Therapy
    Matthew Palmer; Fiscal Year: 2002
    Neutron capture therapy (NCT) is a unique form of radiation due to the combination of high linear energy transfer (LET) properties and biological targeting...
  15. Chelator for a Therapeutic Ra-223 Radiopharmaceutical
    TERESIA MOLLER; Fiscal Year: 2004
    ..The high linear energy transfer (LET) and relatively short penetration range (a few cell diameters) makes alpha particles particularly ..
  16. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..might be improved through the use of human chimeric MAbs with increased biostability and the use of high linear energy transfer radioisotopes, such as 211-At, with greater relative biological effectiveness...
  17. RADIATION INDUCED CHROMOSOME DAMAGE IN VIVO
    ANTONE BROOKS; Fiscal Year: 1991
    ..This produces a range or unique exposure patterns to radiation with both high and low linear energy transfer (LET)...
  18. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  19. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  20. INDUCTION OF GENOMIC INSTABILITY IN HUMAN LYMPHOBLASTS
    Helen Evans; Fiscal Year: 2001
    ..Knowledge of the target for the induction of instability and the nature of that instability is important for the development of better predictive models of risk and appropriate radiation protection measures. ..
  21. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  22. Effect of Estrogen on Radiation-induced Cataractogenesis
    JOSEPH DYNLACHT; Fiscal Year: 2005
    ..abstract_text> ..
  23. THE MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2006
    ..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
  24. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2009
    ..abstract_text> ..
  25. MECHANISMS OF FIBER CARCINOGENESIS
    TOM HEI; Fiscal Year: 2001
    ..Cytogenetic and molecular alterations at the gene level will be analyzed from tumors and intermediate transformation stages to provide a mechanistic basis for tumor induction by mineral fibers. ..
  26. Updating Chromosome Aberration Simulator (CAS) Software
    Rainer Sachs; Fiscal Year: 2006
    ..An interdisciplinary team has been assembled for this project. The grant would ensure that a computer resource important to the radiation cytogenetics community is kept fully current and readily available. ..
  27. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
    ..abstract_text> ..
  28. The Role of the Mre11 Complex in Heat-radiosensitization
    JOSEPH DYNLACHT; Fiscal Year: 2007
    ..We will also determine the role of HR in heat-radiosensitization using silencing RNA (siRNA) targeting technology or conditional mutants deficient in specific NHEJ or HR proteins. [unreadable] [unreadable]..
  29. CYTOGENETIC MODELS FOR ASSESSING LOW DOSE RADIATION RISK
    Rainer Sachs; Fiscal Year: 2001
    ..By studying molecular, mechanisms relevant to low doses and low dose-rates quantitatively the project will help firm-up risk estimates and make them more credible. ..
  30. DNA Damage Clusters: Repair in Mammalian Cells
    Betsy Sutherland; Fiscal Year: 2004
    ..Further, knowledge of conditions affecting formation of clustered damages, and cellular paths for dealing with them could allow the design of more effective radiation therapies. ..
  31. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  32. Damage signaling from irradiated to non-irradiated cells
    EDOUARD AZZAM; Fiscal Year: 2004
    ..They are also relevant to diagnostic and therapeutic nuclear medicine where radionuclides are being investigated to detect various diseases and treat cancer. ..
  33. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..detectors in dosimetry for radiation oncology is that their response depends on both absorbed dose and linear energy transfer (LET)...
  34. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  35. P28-DRA IN THE STRESS RESPONSE OF MAMMALIAN CELLS
    Michael Story; Fiscal Year: 2001
    ..Understanding how p28dra functions will provide new insights into overcoming resistance to cancer therapy and possibly lead to new clinical strategies in cancer management. ..
  36. The Role of Telomeres and Telomerase in Cancer
    Jerry Shay; Fiscal Year: 2005
    ..abstract_text> ..
  37. Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation Detectors
    Sam Beddar; Fiscal Year: 2009
    ..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
  38. Better correlation of outcomes with MC dose calculation
    Indrin Chetty; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  39. MECHANISMS OF COLOR DETECTION, INDUCTION AND ADAPTATION
    Qasim Zaidi; Fiscal Year: 2010
    ..The methods developed here will be useful in identifying functional consequences of color vision deficits. PHS 398 (Rev. 05/01) Page 2 Principal Investigator/Program Director (Last, first, middle): ZAIDI, QASIM ..
  40. Carbon Nanotube Field Emission Microbeam Array for Single Cell Irradiation
    Sha Chang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  41. Magnetic Sorter Channels for Stem Cells
    Paul Todd; Fiscal Year: 2006
    ..abstract_text> ..
  42. DIRECT IONIZATION EFFECTS IN DNA
    William Nelson; Fiscal Year: 2002
    ..Final transfer of the results to DNA will be made by carefully selecting and employing the well-defined, DNA-like, systems provided by oligonucleotides. ..
  43. DOSIMETRY OF BRACHYTHERAPY SOURCES IN MILLIMETER RANGE
    Ravinder Nath; Fiscal Year: 2003
    ..The goals of the project are to develop tools for the optimization of dose distributions produced within a target volume and uniformity of dose along and around a blood vessel. ..
  44. 2003 Genetic Toxicology Gordon Conference
    Penny Jeggo; Fiscal Year: 2003
    ..We particularly air to obtain funding to support applications from minority groupings and younger scientists. We have already identified a significant participation of women amongst our list of speakers. ..
  45. RADIODIAGNOSIS & RADIOTHERAPY OF LUNG CANCER METASTASES
    AMIN KASSIS; Fiscal Year: 2004
    ....
  46. Eighth International Workshop on Radiation Damage to DNA
    KATHRYN HELD; Fiscal Year: 2004
    ..abstract_text> ..
  47. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2005
    ..A unique advantage of the SEC is the possibility of including information about the linear energy transfer (LET) which may be of interest in characterizing the effects of low energy radiations that are present ..
  48. Magnetic Flow Sorter for Pancreatic Islet Isolation
    Paul Todd; Fiscal Year: 2005
    ..abstract_text> ..
  49. Gamma Ray Spectroscopy for Dose Rate Constants
    Ravinder Nath; Fiscal Year: 2006
    ..abstract_text> ..
  50. Imaging & Localizing Device Using the Barkhausen Effect
    John Dicello; Fiscal Year: 2003
    ..Existing reconstruction techniques will be adapted to provide absolute spatial information. With fusion, images can be combined with CT, MRI, or PET for anatomical and physiological information. ..
  51. Molecular Targeting of EGFR for the Treatment of Gliomas
    ROLF BARTH; Fiscal Year: 2006
    ..second generation drugs BPA and BSH, produce a significant improvement in survival following BNCT compared to that which we have obtained with BSH and BPA in combination, using the F98EGFR and F98EGFRVIII glioma models?" ..
  52. Mitochondrial Metabolic Defects and Cancer
    Nukhet Aykin Burns; Fiscal Year: 2006
    ..abstract_text> ..
  53. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2008
    ..The results will enhance our effort to establish clinically relevant radiation treatment with a better understanding of potential damage to healthy tissue. [unreadable] [unreadable] [unreadable]..