cochlear microphonic potentials

Summary

Summary: The electric response of the cochlear hair cells to acoustic stimulation.

Top Publications

  1. ncbi A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback
    P K Legan
    School of Biological Sciences, The University of Sussex, Falmer, Brighton, United Kingdom
    Neuron 28:273-85. 2000
  2. ncbi Reverse cochlear propagation in the intact cochlea of the gerbil: evidence for slow traveling waves
    Sebastiaan W F Meenderink
    Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurophysiol 103:1448-55. 2010
  3. ncbi A deafness mutation isolates a second role for the tectorial membrane in hearing
    P Kevin Legan
    School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Nat Neurosci 8:1035-42. 2005
  4. pmc Two-tone distortion at different longitudinal locations on the basilar membrane
    Wenxuan He
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA, and Department of Otolaryngology of First Affiliated Hospital, Xi an, Shaanxi 710061, PR China
    Hear Res 228:112-22. 2007
  5. pmc Using the cochlear microphonic as a tool to evaluate cochlear function in mouse models of hearing
    Mary Ann Cheatham
    Department of Communication Sciences and Disorders, The Hugh Knowles Center, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Assoc Res Otolaryngol 12:113-25. 2011
  6. pmc Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro
    Dylan K Chan
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 8:149-55. 2005
  7. ncbi The origin of the low-frequency microphonic in the first cochlear turn of guinea-pig
    R B Patuzzi
    Department of Physiology, University of Western Australia, Nedlands
    Hear Res 39:177-88. 1989
  8. ncbi Evidence for multiple DPOAE components based upon group delay of the 2f(1)-f(2) distortion in the gerbil
    M Faulstich
    Zoologisches Institut der Universität München, Luisenstr 14, 80333, Munich, Germany
    Hear Res 140:99-110. 2000
  9. ncbi Evaluation of an independent prestin mouse model derived from the 129S1 strain
    M A Cheatham
    Department of Communication Sciences and Disorders, The Hugh Knowles Center, Evanston, IL, USA
    Audiol Neurootol 12:378-90. 2007
  10. ncbi Microphonic and DPOAE measurements suggest a micromechanical mechanism for the 'bounce' phenomenon following low-frequency tones
    D L Kirk
    Physiology Department, University of Western Australia, Nedlands
    Hear Res 112:69-86. 1997

Research Grants

Detail Information

Publications156 found, 100 shown here

  1. ncbi A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback
    P K Legan
    School of Biological Sciences, The University of Sussex, Falmer, Brighton, United Kingdom
    Neuron 28:273-85. 2000
    ..Thus, the tectorial membrane ensures that outer hair cells can effectively respond to basilar membrane motion and that feedback is delivered with the appropriate gain and timing required for amplification...
  2. ncbi Reverse cochlear propagation in the intact cochlea of the gerbil: evidence for slow traveling waves
    Sebastiaan W F Meenderink
    Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurophysiol 103:1448-55. 2010
    ..These delays remained significant after compensating for middle-ear delay. The results contradict the hypothesis that the reverse propagation of emissions is exclusively by direct pressure waves...
  3. ncbi A deafness mutation isolates a second role for the tectorial membrane in hearing
    P Kevin Legan
    School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Nat Neurosci 8:1035-42. 2005
    ..Thus, using Tecta(Y1870C/+) mice, we have genetically isolated a second major role for the tectorial membrane in hearing: it enables the motion of the basilar membrane to optimally drive the inner hair cells at their best frequency...
  4. pmc Two-tone distortion at different longitudinal locations on the basilar membrane
    Wenxuan He
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA, and Department of Otolaryngology of First Affiliated Hospital, Xi an, Shaanxi 710061, PR China
    Hear Res 228:112-22. 2007
    ..The data indicate that the emission travels along the BM from base to apex as a forward traveling wave, and no backward traveling wave was detected under the current experimental conditions...
  5. pmc Using the cochlear microphonic as a tool to evaluate cochlear function in mouse models of hearing
    Mary Ann Cheatham
    Department of Communication Sciences and Disorders, The Hugh Knowles Center, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Assoc Res Otolaryngol 12:113-25. 2011
    ..Based on this current evaluation, CM measurements are consistent with early descriptions where this AC cochlear potential is dominated by basal OHCs, when recorded at the round window...
  6. pmc Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro
    Dylan K Chan
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 8:149-55. 2005
    ..These results suggest that the Ca(2+) current drives the cochlear active process, and they support the hypothesis that active hair-bundle motility underlies cochlear amplification...
  7. ncbi The origin of the low-frequency microphonic in the first cochlear turn of guinea-pig
    R B Patuzzi
    Department of Physiology, University of Western Australia, Nedlands
    Hear Res 39:177-88. 1989
    ..It is a convenient and relatively uncomplicated indicator of the integrity of the mechano-electrical transduction process of these cells...
  8. ncbi Evidence for multiple DPOAE components based upon group delay of the 2f(1)-f(2) distortion in the gerbil
    M Faulstich
    Zoologisches Institut der Universität München, Luisenstr 14, 80333, Munich, Germany
    Hear Res 140:99-110. 2000
    ..5 kHz but failed to reflect the sensitivity for lower frequencies. This may be a consequence of more linear frequency processing in the apex...
  9. ncbi Evaluation of an independent prestin mouse model derived from the 129S1 strain
    M A Cheatham
    Department of Communication Sciences and Disorders, The Hugh Knowles Center, Evanston, IL, USA
    Audiol Neurootol 12:378-90. 2007
    ..The linkage shown between the loss of prestin protein and abnormal cochlear function validates the original knockout and attests to the importance of OHC motor function in the auditory periphery...
  10. ncbi Microphonic and DPOAE measurements suggest a micromechanical mechanism for the 'bounce' phenomenon following low-frequency tones
    D L Kirk
    Physiology Department, University of Western Australia, Nedlands
    Hear Res 112:69-86. 1997
    ..We suggest that the shift in operating point is largely responsible for the increase in cochlear sensitivity, and is due to a disruption of the salt balance within the cochlea during the intense low-frequency tone...
  11. ncbi Systemic co-treatment with alpha-melanocyte stimulating hormone delays hearing loss caused by local cisplatin administration in guinea pigs
    Francisca L C Wolters
    Hearing Research Laboratories, University Medical Center Utrecht, Room G02 531, P O Box 85 500, 3508 GA Utrecht, The Netherlands
    Hear Res 179:53-61. 2003
    ..Since cisplatin was delivered directly to the cochlea, the ameliorating effect of alpha-MSH probably involves a cochlear target...
  12. pmc Altered traveling wave propagation and reduced endocochlear potential associated with cochlear dysplasia in the BETA2/NeuroD1 null mouse
    Anping Xia
    The Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, One Baylor Plaza, NA102, Houston, TX 77030, USA
    J Assoc Res Otolaryngol 8:447-63. 2007
    ..Additionally, the presence of electrically evoked otoacoustic emissions suggests that outer hair cell reverse transduction is present, although the acoustic response is shaped by the alterations in cochlear mechanics...
  13. ncbi Thapsigargin suppresses cochlear potentials and DPOAEs and is toxic to hair cells
    Richard P Bobbin
    Kresge Hearing Research Laboratory, Department of Otorhinolaryngology and Biocommunication, Louisiana State University Health Sciences Center, 533 Bolivar Street, 5th Floor, New Orleans, LA 70112 2234, USA
    Hear Res 184:51-60. 2003
    ..These effects are consistent with the hypothesis that the inhibition of the SERCAs affects the function of the cochlear amplifier and outer hair cells to a greater degree than it affects other functions of the cochlea...
  14. ncbi Objective estimates of cochlear tuning by otoacoustic emission analysis
    Arturo Moleti
    Dipartimento di Fisica, Universita di Roma Tor Vergata, Via della Ricerca Scientifica, 1, 00133 Roma, Italy
    J Acoust Soc Am 113:423-9. 2003
    ..Theoretical relations are derived, which connect these two measured quantities and the tuning curve. The typically longer latency of neonates implies a higher degree of tuning at high levels of stimulation...
  15. ncbi Stiffness of the gerbil basilar membrane: radial and longitudinal variations
    Gulam Emadi
    Department of Biomedical Engineering, Northwestern University, Evanston 60208, USA
    J Neurophysiol 91:474-88. 2004
    ..The bulk of our data was obtained in the hemicochlea preparation, and we include a comparison of this set of data to data obtained in vivo...
  16. ncbi Development of cochlear amplification, frequency tuning, and two-tone suppression in the mouse
    Lei Song
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Neurophysiol 99:344-55. 2008
    ..These findings support a traditional view of development in which the maturation of passive transduction precedes the maturation of active mechanics in the most sensitive region of the mouse cochlea...
  17. ncbi Quinine-induced alterations of electrically evoked otoacoustic emissions and cochlear potentials in guinea pigs
    J Zheng
    Oregon Hearing Research Center, Department of Otolaryngology/Head and Neck Surgery, Oregon Health Sciences University, Portland 97201-3098, USA
    Hear Res 154:124-34. 2001
    ..Its effects on the cochlear spiral ganglion neurons and/or their presynaptic process are also suggested, and these are speculated to be the primary sites for quinine's effects on the auditory system...
  18. ncbi Perilymphatic application of cisplatin over several days in albino guinea pigs: dose-dependency of electrophysiological and morphological effects
    S F Klis
    Hearing Research Laboratories, University Medical Center, Utrecht, The Netherlands
    Hear Res 154:135-45. 2001
    ..5-2.0 mg/kg. The cochlear pathology from the parenteral treatment was greater than that observed with 30 microg/ml pumps, and less than that from 300 microg/ml pumps...
  19. ncbi Electrically evoked otoacoustic emissions from the chicken ear
    L Chen
    Hearing Research Laboratories, 215 Parker Hall, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, South Campus, Buffalo, NY 14214, USA
    Hear Res 161:54-64. 2001
    ..These results suggest that the EEOAE has a biological origin in the cochlea, which could presumably involve electrically evoked stereocilia bundle movements...
  20. ncbi Non-linear aspects of outer hair cell transduction and the temporary threshold shifts after acoustic trauma
    Robert Patuzzi
    Auditory Laboratory, Physiology, University of Western Australia, Nedlands, W A, Australia
    Audiol Neurootol 7:17-20. 2002
    ..e. in the direction normally causing hyperpolarisation of the cell membrane potential)...
  21. ncbi Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential
    Shin ichiro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, 606 8501, Japan
    J Cell Sci 117:5087-96. 2004
    ....
  22. ncbi Ethacrynic acid rapidly and selectively abolishes blood flow in vessels supplying the lateral wall of the cochlea
    Dalian Ding
    Center for Hearing and Deafness, 215 Parker Hall, University at Buffalo, NY 14214, USA
    Hear Res 173:1-9. 2002
    ..The ischemia-reperfusion caused by EA would be expected to generate large quantities of free radicals, which may trigger or contribute to the cellular, enzymatic, and functional pathologies that have been described in detail previously...
  23. ncbi Loud sound-induced changes in cochlear mechanics
    Anders Fridberger
    Karolinska Institutet, Department of Physiology and Pharmacology, SE 171 77 Stockholm, Sweden
    J Neurophysiol 88:2341-8. 2002
    ....
  24. ncbi Caffeine and ryanodine demonstrate a role for the ryanodine receptor in the organ of Corti
    Richard P Bobbin
    Kresge Hearing Research Laboratories, Department of Otorhinolaryngology and Biocommunication, Louisiana State University Health Sciences Center, 533 Bolivar Street, 5th Floor, New Orleans, LA 70112 2234, USA
    Hear Res 174:172-82. 2002
    ..This is consistent with the hypothesis that release of Ca(2+) from ryanodine receptor Ca(2+) stores, possibly in outer hair cells and supporting cells, affects the function of the cochlear amplifier...
  25. ncbi Sound-evoked efferent effects on cochlear mechanics of the mustached bat
    Markus Drexl
    Department Biologie II der Ludwig Maximilians Universität München, Luisenstrasse 14, D 80333 Munich, Germany
    Hear Res 184:61-74. 2003
    ....
  26. ncbi Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the guinea pig cochlea
    Sabine Ladrech
    INSERM U583 et Universités Montpellier I et II, Physiopathologie et Therapie des deficits sensoriels et moteurs, 71, rue de Navacelles, 34090 Montpellier, France
    Hear Res 186:85-90. 2003
    ..Neurite regrowth seems to involve the MAP2c isoform. In cochlear neurons, mechanisms involved in the period of development might be reactivated after excitotoxic injury in the mature cochlea...
  27. pmc Conservation of hearing by simultaneous mutation of Na,K-ATPase and NKCC1
    Rodney C Diaz
    Department of Otolaryngology Head and Neck Surgery, University of California Davis School of Medicine, 1515 Newton Court, Davis, CA 95618, USA
    J Assoc Res Otolaryngol 8:422-34. 2007
    ..These observations provide insight into the detailed mechanisms of EP generation, and results of combination-knockout experiments may have important implications in the future treatment of drug-induced and age-related hearing losses...
  28. ncbi Prestin gene expression in the rat cochlea following intense noise exposure
    Guang Di Chen
    Center for Hearing and Deafness, 137 Cary Hall, 3435 Main Street, SUNY at Buffalo, Buffalo, NY 14214, USA
    Hear Res 222:54-61. 2006
    ..The up-regulated gene expression may be in response to injury of the proteins, which may be responsible for the loss of cochlear amplification...
  29. ncbi Prolonged maturation of cochlear function in the barn owl after hatching
    Christine Köppl
    Lehrstuhl für Zoologie, Technische Universitat Munchen, Lichtenbergstr 4, 85747 Garching, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:613-24. 2007
    ..Compound action potential amplitudes matured even later, at about 3 months posthatching, at all frequencies. This suggests a prolonged immaturity in the temporal synchrony of spiking in the auditory nerve...
  30. ncbi Cochlear traveling-wave amplification, suppression, and beamforming probed using noninvasive calibration of intracochlear distortion sources
    Christopher A Shera
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 121:1003-16. 2007
    ..Rather, the dominant factor governing the emission magnitude appears to be the variable directionality of the waves radiated by the distortion-source region, which acts as a distortion beamformer tuned by the primary frequency ratio...
  31. ncbi The cochlear targets of cisplatin: an electrophysiological and morphological time-sequence study
    Marjolein W M van Ruijven
    Hearing Research Laboratories, Department of Otorhinolaryngology, University Medical Center Utrecht, P O Box 85 500, 3508 GA Utrecht, The Netherlands
    Hear Res 205:241-8. 2005
    ..This time sequence has not revealed any evidence of one ototoxic process triggering another. Therefore, we have to stay with the conclusion of Van Ruijven et al. (2004) that both processes run in parallel...
  32. ncbi ATP-gamma-S shifts the operating point of outer hair cell transduction towards scala tympani
    Richard P Bobbin
    Kresge Hearing Research Laboratory, Department of Otolaryngology, Louisiana State University School of Medicine, New Orleans, LA 70112 2234, USA
    Hear Res 205:35-43. 2005
    ..Results are consistent with an ATP-gamma-S induced transducer change comparable to a static movement of the organ of Corti or reticular lamina towards scala tympani...
  33. ncbi Endolymphatic perfusion with EGTA-acetoxymethyl ester inhibits asphyxia- and furosemide-induced decrease in endocochlear potential in guinea pigs
    Akihito Mineharu
    Department of Physiology II and Department of Otolaryngology, Osaka Medical College, Takatsuki, Osaka, 569 8686 Japan
    Jpn J Physiol 55:53-60. 2005
    ..In contrast, perilymphatic administration of 0.5 mM EGTA-AM caused no significant suppression of the DeltaEP(asp). These findings suggest that [Ca](i) plays an important role in generating/maintaining a large positive EP...
  34. pmc Wiener kernels of chinchilla auditory-nerve fibers: verification using responses to tones, clicks, and noise and comparison with basilar-membrane vibrations
    Andrei N Temchin
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
    J Neurophysiol 93:3635-48. 2005
    ....
  35. ncbi Analytic treatment of the compound action potential: estimating the summed post-stimulus time histogram and unit response
    Mark E Chertoff
    Department of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66103 0001, USA
    J Acoust Soc Am 116:3022-30. 2004
    ..The decay of U(t) was largest at 8 kHz and smallest at 1 kHz. These results indicate that the hair cell or neural mechanisms involved in the generation of action potentials may differ along the cochlear partition...
  36. ncbi Constructing a cochlear transducer function from the summating potential using a low-frequency bias tone
    Chul Hee Choi
    Bobby R Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    J Acoust Soc Am 116:2996-3007. 2004
    ..This suggests that the low-frequency modulated SP amplitude can be used to construct a cochlear transducer function...
  37. ncbi Differential intracochlear recordings of ensemble background activity (EBA)
    Jianxun Zhou
    J Acoust Soc Am 116:2738-41. 2004
  38. ncbi Endocochlear potential and endolymphatic K+ changes induced by gap junction blockers
    Masaaki Suzuki
    Department of Otorhinolaryngology Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Acta Otolaryngol 124:902-6. 2004
    ..To examine the effects of gap junction blockers on the endocochlear potential (EP) and endolymphatic potassium concentration ([K(+)](e))...
  39. pmc Hearing: travelling wave or resonance?
    Andrew Bell
    Laboratory of Mandyam Srinivasan at the Research School of Biological Sciences at the Australian National University, Canberra, Australia
    PLoS Biol 2:e337. 2004
  40. pmc Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea?
    M C Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 116:1649-55. 2004
    ....
  41. ncbi Age-related hearing loss: the status of Schuknecht's typology
    Kevin K Ohlemiller
    Department of Otolaryngology, Washington University, St Louis, Missouri, USA
    Curr Opin Otolaryngol Head Neck Surg 12:439-43. 2004
    ..Only recently has our understanding of cellular changes and gene/environment interactions in ARHL achieved the level needed for hypothesis-driven experiments in this area...
  42. ncbi The influence of transducer operating point on distortion generation in the cochlea
    Davud B Sirjani
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Acoust Soc Am 115:1219-29. 2004
    ..Understanding the factors influencing operating point is important in the interpretation of distortion measurements and may lead to tests that can detect abnormal endolymph volume states...
  43. ncbi Effect of intracochlear perfusion of vanilloids on cochlear neural activity in the guinea pig
    Jianxun Zhou
    Department of Communication Science and Disorders, University of Pittsburgh, Forbes Tower 4033, Pittsburgh, PA 15260, USA
    Hear Res 218:43-9. 2006
    ..These findings are consistent with the hypothesis that TRPV1 activation increases background activity of spiral ganglion cells and support a role of TRPV1 in gating spontaneous and evoked auditory nerve excitability...
  44. pmc Age-related auditory pathology in the CBA/J mouse
    Su Hua Sha
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109 5616, USA
    Hear Res 243:87-94. 2008
    ..The superimposed early hearing loss at low frequencies, which is not seen in animals bred in-house, may complicate the use of these animals as a presbycusis model...
  45. ncbi Does repeated hyperbaric exposure to 4 atmosphere absolute cause hearing impairment? Study in Guinea pigs and clinical incidences
    Renaud Meller
    Neurotologie et de Microendoscopie, Faculte de Medecine Nord, Marseille, France
    Otol Neurotol 24:723-7. 2003
    ..Direct pressure applied on the inner ear cannot induce hearing loss...
  46. ncbi Disruption of cochlear potentials by chemical asphyxiants. Cyanide and carbon monoxide
    W Tawackoli
    Oklahoma Center for Toxicology, College of Pharmacy, University of Oklahoma Health Sciences Center, 1110 North Stonewall Street, PO Box 26901, Oklahoma City, OK 73190, USA
    Neurotoxicol Teratol 23:157-65. 2001
    ..The principal target for acute CO ototoxicity in the cochlea is probably not the stria vascularis...
  47. ncbi Cochlear dysfunction in the jerker mouse
    K P Steel
    Behav Neurosci 97:381-91. 1983
    ..During anoxia induced in adults, EP fell to a significantly less negative value in mutants than in control mice. This abnormality in the anoxia potential probably reflects an organ of Corti abnormality...
  48. ncbi Perilymphatic application of alpha-melanocyte stimulating hormone ameliorates hearing loss caused by systemic administration of cisplatin
    Francisca L C Wolters
    Hearing Research Laboratories, Department of Otorhinolaryngology, University Medical Center Utrecht, NL 3508 GA Utrecht, The Netherlands
    Hear Res 189:31-40. 2004
    ..Since alpha-MSH was directly delivered to the cochlea, the ameliorating effect of alpha-MSH on OHC survival is likely to involve a cochlear target...
  49. ncbi Spatial processing within the mustache bat echolocation system: possible mechanisms for optimization
    Z M Fuzessery
    Department of Zoology Physiology, University of Wyoming, Laramie 82071
    J Comp Physiol A 170:57-71. 1992
    ..free-field sounds throughout the frontal sound field, and recording the intensity thresholds of cochlear microphonic potentials, and the intensity thresholds of monaural neurons in the inferior colliculus tuned to one of the 3 ..
  50. ncbi Cochlear activation at low sound intensities by a fluid pathway
    Haim Sohmer
    Department of Physiology, Hebrew University Hadassah Medical School, Hadassah University Hospital, Jerusalem, Israel
    J Basic Clin Physiol Pharmacol 15:1-14. 2004
    ..The thresholds of the auditory nerve brainstem evoked responses (ABR) and of the cochlear microphonic potentials were not affected in the fenestration experiments...
  51. ncbi Cochlear microphonic potentials in patients with vestibular schwannomas
    Y Noguchi
    Department of Otolaryngology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 60:283-90. 1998
    We evaluated the cochlear function of 44 patients with unilateral vestibular schwannomas by measuring cochlear microphonic potentials (CM) in electrocochleography. We used short tone bursts with 0...
  52. ncbi A method for introducing non-silencing siRNA into the guinea pig cochlea in vivo
    P Sellick
    The Auditory Laboratory, Discipline of Physiology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Australia
    J Neurosci Methods 167:237-45. 2008
    ..siRNA uptake was observed predominantly in marginal and intermediate cells of the stria vascularis in all cochlear turns but not in cells of the organ of Corti...
  53. ncbi The influence of post-meningitic obliteration and ossification of the cochlea on cochlear microphonics
    Magnus Teschner
    Department of Otolaryngology, Medical University of Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Eur Arch Otorhinolaryngol 267:1547-50. 2010
    ..This study does not demonstrate evidence of a change in this property due to ossification or obliteration of the cochlea...
  54. ncbi [Effects of aminoglycoside antibiotics on various structures of the acoustic analyzer]
    V P Fisenko
    Department of Pharmacology, Sechenov Medical Academy, ul Bol shaya Pirogovskaya 2 6, Moscow, 119881 Russia
    Eksp Klin Farmakol 66:42-5. 2003
    ....
  55. ncbi Intelligibility of sentences recorded from the uterus of a pregnant ewe and from the fetal inner ear
    Sherri L Smith
    Department of Communication Sciences and Disorders, Institute for the Advanced Studies of Communication Processes, University of Florida, Gainesville, FL 32611, USA
    Audiol Neurootol 8:347-53. 2003
    ....
  56. ncbi Additional pharmacological evidence that endogenous ATP modulates cochlear mechanics
    C Chen
    Kresge Hearing Research Laboratory of the South, Department of Otorhinolaryngology and Biocommunication, Louisiana State University Medical Center, New Orleans 70112 2234, USA
    Hear Res 118:47-61. 1998
    ..These results, together with the similar effects of the ATP antagonist suramin reported previously (Skellett et al., 1997), may be evidence that endogenous ATP acting on cells in the organ of Corti alters cochlear mechanics...
  57. pmc Membrane cholesterol modulates cochlear electromechanics
    William E Brownell
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Pflugers Arch 461:677-86. 2011
    ..of the response, without changing the frequency tuning of sound-evoked mechanical responses or cochlear microphonic potentials. Sodium salicylate reversibly blocked the enhanced electromechanical response in cholesterol depleted ..
  58. ncbi Gastric type H+,K+-ATPase in the cochlear lateral wall is critically involved in formation of the endocochlear potential
    Toshiaki Shibata
    Div of Molecular and Cellular Pharmacology, Department of Pharmacology, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Am J Physiol Cell Physiol 291:C1038-48. 2006
    ..These results may imply that the H(+),K(+)-ATPase in the cochlear lateral wall is crucial for K(+) circulation and thus plays a critical role in generation of EP...
  59. ncbi Characteristics of cochlear microphonics in infants and young children with auditory neuropathy
    Wei Shi
    Department of Otolaryngology Head and Neck Surgery, Chinese PLA Institute of Otolaryngology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China
    Acta Otolaryngol 132:188-96. 2012
    ..It is necessary and helpful to diagnose the sites-of-lesion in infants and children with AN by analyzing the patterns of CM amplitudes and I/O functions together...
  60. ncbi [Evoked oto-acoustic emissions in patients with retinitis pigmentosa]
    C Simoncelli
    Istituto di Clinica Otorinolaringoiatrica,
    Acta Otorhinolaryngol Ital 11:563-70. 1991
    ..It seems likely that the auditory system is involved in retinitis pigmentosa degenerative processes more frequently than traditional audiometric tests have been able to show...
  61. ncbi Differential ototoxicities induced by lead acetate and tetraethyl lead
    Umit Tuncel
    Division of Otolaryngology Head and Neck Surgery, Ankara Numune Teaching and Research Hospital, Ankara, Turkey
    Hear Res 166:113-23. 2002
    ..01). These data suggest that TEL is more ototoxic than is LA and that free radicals partially mediate TEL-induced CAP disruption...
  62. ncbi Blebs in inner and outer hair cells: a pathophysiological hypothesis
    R Ramirez-Camacho
    Ear Research Group, Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro, Autonoma University of Madrid, Spain
    J Laryngol Otol 122:1151-5. 2008
    ..The present study was undertaken to identify the possible role of inner and outer hair cell blebs in the pathogenesis of cisplatin-induced ototoxicity...
  63. ncbi Partial recovery of cisplatin-induced hearing loss in the albino guinea pig in relation to cisplatin dose
    Sjaak F L Klis
    Hearing Research Laboratories, University Medical Center, Room G 02 531, Heidelberglaan 100, NL 3584 CX Utrecht, The Netherlands
    Hear Res 164:138-46. 2002
    ..Thus, loss and recovery of cochlear potentials can for a large part be explained by loss and recovery of the EP. Recovery is limited by permanent OHC loss...
  64. ncbi [Temporary threshold shift after nuclear magnetic resonance tomography]
    E Zwicker
    Institut für Elektroakustik der Technischen Universität München
    Laryngorhinootologie 69:413-6. 1990
    ..These effects could be verified objectively using otoacoustic emissions. The consequences especially for patients with already impaired hearing are discussed: ear protection is strongly recommended...
  65. ncbi Dopamine transporter is essential for the maintenance of spontaneous activity of auditory nerve neurones and their responsiveness to sound stimulation
    Jérôme Ruel
    Institut National de la Santé et de la Recherche Médicale U583, Institut des Neurosciences de Montpellier and University of Montpellier 1, Montpellier, France
    J Neurochem 97:190-200. 2006
    ..Altogether, these results show that the dopamine transporter is essential for maintaining the spontaneous activity of auditory nerve neurones and their responsiveness to sound stimulation...
  66. doi Assessment of cochlear function in mice: distortion-product otoacoustic emissions
    Glen K Martin
    Jerry Pettis Memorial Veterans Medical Center and Loma Linda University, Loma Linda, California, USA
    Curr Protoc Neurosci . 2006
    ..Examples of data analysis procedures following noise exposure in mice are included, as well. These methods are not only applicable to mice, but can be performed using essentially all small laboratory animals...
  67. pmc An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells
    Kazusaku Kamiya
    Institut Pasteur, Génétique et Physiologie de l Audition, 75015 Paris, France Institut National de la Santé et de la Recherche Médicale, Unite Mixte de Recherche, UMR S 1120 Paris, France Sorbonne Universités, UPMC Univ Paris 06, Complexité Du Vivant, 75252 Paris Cedex 05, France Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Juntendo University, Tokyo 1138421, Japan
    Proc Natl Acad Sci U S A 111:9307-12. 2014
    ..nonresponding OHCs at the cochlear base as assessed by distortion-product otoacoustic emissions and cochlear microphonic potentials. Moreover, unlike wild-type mice, responses of Nherf1(-/-) mice to high-frequency (20-40 kHz) test ..
  68. ncbi Validity of cochlear microphonics at high sound pressure levels as an important clinical aspect
    M Teschner
    Department of Otolaryngology, Medical University of Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    ORL J Otorhinolaryngol Relat Spec 74:38-41. 2012
    ..As artifacts at high sound pressure levels suggested, measurements were subsequently conducted using temporal bone specimens...
  69. ncbi Cochlear implantation in a patient with sensori-neural deafness secondary to Charcot-Marie-Tooth disease
    Jay Goswamy
    Manchester Royal Infirmary, Manchester, UK
    Cochlear Implants Int 13:184-7. 2012
    ....
  70. ncbi Expression and function of adenosine receptors in the chinchilla cochlea
    M S Ford
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794, USA
    Hear Res 105:130-40. 1997
    ..These results suggest a potential cytoprotective role of adenosine in the cochlea against oxidative damage...
  71. ncbi The effect of BAPTA and 4AP in scala media on transduction and cochlear gain
    P M Sellick
    The Auditory Laboratory, Discipline of Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, WA 6009, Australia
    Hear Res 211:7-15. 2006
    ..The effect of 4AP and BAPTA on neural threshold and the receptor current represented by CM may be explained by their action on OHC transduction without the involvement of IHCs...
  72. ncbi Effects of aging on potassium homeostasis and the endocochlear potential in the gerbil cochlea
    R A Schmiedt
    Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston 29425 2242, USA
    Hear Res 102:125-32. 1996
    ..Thus, the system maintains Ke+ homeostasis at the expense of the EP, even when the EP is on the verge of collapse...
  73. ncbi [Study of unilateral auditory neuropathy in infants]
    Dengyuan Wang
    Department of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:729-32. 2005
    ..To study neurophysiological characteristics in infants with unilateral auditory neuropathy (UAN)...
  74. ncbi Does BAPTA leave outer hair cell transduction channels closed?
    P M Sellick
    The Auditory Laboratory, Discipline of Physiology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Nedlands, WA 6009, Australia
    Hear Res 224:84-92. 2007
    ..These findings are consistent with a model of hair cell transduction in which tension on stereo cilia opens the transduction channels...
  75. pmc Intraoperative round window recordings to acoustic stimuli from cochlear implant patients
    Baishakhi Choudhury
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7070, USA
    Otol Neurotol 33:1507-15. 2012
    ..Acoustically evoked neural and hair cell potentials can be measured from the round window (RW) intraoperatively in the general population of cochlear implant recipients...
  76. ncbi Physiological effects of auditory nerve myelinopathy in chinchillas
    Mohamed M El-Badry
    Otolaryngology Department, Audiology Unit, El Minia University Hospitals, El Minia University, El Minia, Egypt
    Eur J Neurosci 25:1437-46. 2007
    ..The results support auditory nerve myelinopathy as a possible pathomechanism of auditory neuropathy but indicate that myelinopathy must be severe before physiological measures are affected...
  77. doi Editorial: 'auditory neuropathy' and cochlear implantation - myths and facts
    William P R Gibson
    Cochlear Implants Int 9:1-7. 2008
    ..Rather than continuing to use a blanket and often misleading term, we are now in a better position to describe each individual case exhibiting this phenomenon according to the correct site of lesion...
  78. ncbi Concomitant changes in the acoustic impedance and the cochlear microphonic potentials during twitch contractions of the middle ear muscles in cats
    S Freeman
    Department of Physiology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Arch Otorhinolaryngol 245:311-5. 1988
    ..This may imply that decreases in impedance measured during the initial phase of the acoustic reflex in man are true decreases and are not due to transient decoupling of the ossicular chain at any point...
  79. ncbi Volume flow rate of perilymph in the guinea-pig cochlea
    K Ohyama
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110
    Hear Res 35:119-29. 1988
    ..They provide strong evidence that perilymph is not secreted in one region and resorbed at a spatially distant site...
  80. ncbi Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla
    Sandra L McFadden
    Center for Hearing and Deafness, University at Buffalo, 215 Parker Hall, Buffalo, NY 14214, USA
    Brain Res 997:40-51. 2004
    ..The rapid time course of efferent fiber and SGN loss in the chinchilla may make it a practical model for studying mechanisms of neural loss and survival in the mammalian inner ear...
  81. ncbi Electrocochleographic and mechanical assessment of round window stimulation with an active middle ear prosthesis
    Kanthaiah Koka
    Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO 80045, USA
    Hear Res 263:128-37. 2010
    ..Mechanical stimulation of the RW with an AMEP produces cochlear responses (CMs) and stapes velocities that are functionally equivalent to acoustic stimulation...
  82. ncbi Auditory input to CNS is acquired coincidentally with development of inner ear after formation of functional afferent pathway in zebrafish
    Masashi Tanimoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Neurosci 29:2762-7. 2009
    ..These results suggest that the functional maturation of inner ear after formation of the auditory pathway is a critical process in the acquisition of auditory inputs by CNS neurons...
  83. ncbi Low-frequency acoustic modulations generated by the high-frequency portion of the cochlea, noninvasively recorded from the scalp of mice (Mus musculus)
    K R Henry
    Department of Psychology, University of California, Davis 95616 8686, USA
    J Comp Psychol 114:22-35. 2000
    ..These measurements may provide a nontraumatic means of repeatedly assessing cochlear functions involved in sound localization and perception of vocalizations...
  84. ncbi The cochlear microphonic potential does not reflect the passive basilar membrane traveling wave
    R Perez
    Department of Otolaryngology and Head and Neck Surgery, Shaare Zedek Medical Center, Jerusalem, Israel
    J Basic Clin Physiol Pharmacol 18:159-72. 2007
    ..The space-time pattern of the basilar membrane traveling wave in the cochlea is thought to be responsible for generation of the CM and its pattern along the cochlea. This relationship was studied in two experiments. EXPERIMENT I:..
  85. ncbi Cochlear microphonics for hearing preservation in vestibular schwannoma surgery
    Y Noguchi
    Department of Otolaryngology, School of Medicine, Tokyo Medical and Dental University, Japan
    Laryngoscope 109:1982-7. 1999
    ..To determine whether cochlear function is beneficial in decision-making concerning the selection of hearing preservation surgery for vestibular schwannoma...
  86. ncbi The middle ear of gekkonoid lizards: interspecific variation of structure in relation to body size and to auditory sensitivity
    Yehudah L Werner
    Department of Evolution, Systematics and Ecology, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Hear Res 167:33-45. 2002
    ..Hence the apparent sensitivity hypothetically depends on both middle ear dimensions and summation of inner ear output. This hypothesis requires verification by other methods...
  87. ncbi Outer hair cells functionally and structurally deteriorate during reperfusion
    Keiji Tabuchi
    Department of Otolaryngology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Japan
    Hear Res 173:153-63. 2002
    ..These results indicate that cochlear reperfusion induces functional and structural deterioration of OHC probably by hydroxyl radical generation...
  88. ncbi Measures of cochlear travelling wave delay in humans: I. Comparison of three techniques in subjects with normal hearing
    M B Serbetçioğlu
    Centre for Human Communication and Deafness, Faculty of Education, University of Manchester, UK
    Acta Otolaryngol 119:537-43. 1999
    ..Among the dependent variables investigated, measures of delay are to be preferred over velocity since the latter are based on uncertain values of cochlear distance...
  89. ncbi Audiological and electrocochleography findings in hearing-impaired children with connexin 26 mutations and otoacoustic emissions
    Rosamaria Santarelli
    Department of Medical and Surgical Specialities, Audiology and Phoniatric Service, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy
    Eur Arch Otorhinolaryngol 265:43-51. 2008
    ..We suggest that neonatal hyperbilirubinemia may play a role in protecting outer hair cells against the damage induced by GJB2 mutations...
  90. ncbi Auditory neuropathy/dys-synchrony: diagnosis and management
    Charles I Berlin
    Department of Otolaryngology, Kresge Hearing Research Laboratory, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Ment Retard Dev Disabil Res Rev 9:225-31. 2003
    ..Recommendations for management include visual language exposure through methods such as American Sign Language (ASL), Cued Speech, or baby signs, and closely following patients...
  91. ncbi High-frequency hearing impairment assessed with cochlear microphonics
    Ming Zhang
    Departments of Speech Pathology and Audiology and Surgery Otolaryngology, University of Alberta and Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
    Acta Otolaryngol 132:967-73. 2012
    ..Cochlear microphonic (CM) measurements may potentially become a supplementary approach to otoacoustic emission (OAE) measurements for assessing low-frequency cochlear functions in the clinic...
  92. ncbi Extratympanic electrocochleography in the diagnosis of auditory neuropathy/auditory dyssynchrony
    Adriana Ribeiro Tavares Anastasio
    FMRP, USP, SP, Brazil
    Braz J Otorhinolaryngol 74:132-6. 2008
    ..In the absence of otoacoustic emissions, many cases of AN/AD have been diagnosed by the presence of CM identified in the BAEP...
  93. pmc Active cochlear amplification is dependent on supporting cell gap junctions
    Yan Zhu
    Department of Otolaryngology, University of Kentucky Medical School, Lexington, Kentucky 40536, USA
    Nat Commun 4:1786. 2013
    ..Our study demonstrates that active cochlear amplification in vivo is dependent on supporting cell gap junctions. These new findings also show that connexin 26 deficiency can reduce active cochlear amplification to induce hearing loss...
  94. pmc Analysis of the cochlear microphonic to a low-frequency tone embedded in filtered noise
    Mark E Chertoff
    Department of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Acoust Soc Am 132:3351-62. 2012
    ....
  95. pmc Energy extraction from the biologic battery in the inner ear
    Patrick P Mercier
    Microsystem Technology Laboratories, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Biotechnol 30:1240-3. 2012
    ..With future optimization of electrode design, we envision using the biologic battery in the inner ear to power chemical and molecular sensors, or drug-delivery actuators for diagnosis and therapy of hearing loss and other disorders...
  96. pmc Progress in cochlear physiology after Békésy
    John J Guinan
    Eaton Peabody Laboratories, Dept of Otolaryngology, Mass Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 293:12-20. 2012
    ..Finally, we touch on cochlear pathologies including noise damage and aging, with an emphasis on where the field might go in the future...
  97. ncbi [A procedure to obtain the recruitment using cochlear microphonic potentials]
    Julio Sanjuán Juaristi
    Servicio de Otorrinolaringologia, Hospital Ramon y Cajal, Madrid, Spain
    Acta Otorrinolaringol Esp 59:102-7. 2008
    ..The system allows recruitment to be measured down to one tenth of a decibel; the precision necessary to differentiate the auditory capacity of patients...
  98. ncbi Evaluating the maximum playback sound levels from portable digital audio players
    Stephen E Keith
    Consumer and Clinical Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, Ontario, K1A 1C1 Canada
    J Acoust Soc Am 123:4227-37. 2008
    ..Measurement of noise levels 0.25 m from the earphone showed that a bystander is unlikely to accurately judge listener sound levels...
  99. ncbi Rupture of Reissner's membrane during acute endolymphatic hydrops in the guinea pig: a model for Ménière's disease?
    W L Valk
    Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands
    Acta Otolaryngol 126:1030-5. 2006
    ..This might be consistent with the hypothesis that an endolymphatic hydrops is a marker of disordered inner ear homeostasis rather than the cause of the clinical symptoms of Ménière's disease...
  100. ncbi Cochlear microphonic audiometry: a new hearing test for objective diagnosis of deafness
    Joaquin Poch-Broto
    ENT Service, Madrid, Spain
    Acta Otolaryngol 129:749-54. 2009
    ..Therefore, CMA could be used as an alternative test to obtain the audiometric profile of these patients...
  101. ncbi Prevalence of auditory neuropathy (AN) among infants and young children with severe to profound hearing loss
    Hossam Sanyelbhaa Talaat
    Audiology Unit, ENT Dept, Menoufiya University, Egypt
    Int J Pediatr Otorhinolaryngol 73:937-9. 2009
    ..Those infants were reassessed in our centers for detecting cases with auditory neuropathy. The study group was subjected to immittancemetry, behavioral observation audiometry, ABR and cochlear microphonics...

Research Grants14

  1. CLINICAL MEASURES OF AUDITORY LINEAR/NONLINEAR PROCESSES
    MARK CHERTOFF; Fiscal Year: 2004
    ..abstract_text> ..
  2. Drug manipulation of noise-induced hearing loss
    RICHARD BOBBIN; Fiscal Year: 2002
    ....
  3. Electromechanics of the Cochlear Outer Hair Cell
    William E Brownell; Fiscal Year: 2011
    ..The final result will be a complete description of OHC electromechanical force production and its role in hearing. ..
  4. Auditory nerve encoding of speech with varied acoustics
    Hanna Stevens; Fiscal Year: 2003
    ..abstract_text> ..
  5. Auditory nerve responses to electric pulse trains
    Charles Miller; Fiscal Year: 2009
    ..We expect the results of this work will guide future designs of cochlear-implant speech processors so that modulated stimuli can be better tailored to the encoding capacity of the user's auditory nerve. ..
  6. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2007
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  7. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ..first, middle) The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  8. COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIES
    KEVIN OHLEMILLER; Fiscal Year: 2003
    ..Our experiments will establish how well the dynamics of ROS production predict cochlear injury, and whether progressive deafness genes may impair cochlear ROS regulation. ..
  9. Morphometric Analysis of the Superior Temporal Gyrus
    JOHN RATNANATHER; Fiscal Year: 2007
    ..abstract_text> ..
  10. Studies of cochlear mechanics: otoacoustic emissions
    Tianying Ren; Fiscal Year: 2005
    ..abstract_text> ..
  11. Physiological Studies of Age-Related Hearing Loss
    RICHARD SCHMIEDT; Fiscal Year: 2007
    ..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
  12. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2009
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  13. Plasticity in the dorsal cochlear nucleus
    GULAMALI EMADI; Fiscal Year: 2003
    ..abstract_text> ..
  14. 11th International conference on cochlear implants in children
    Craig Buchman; Fiscal Year: 2007
    ..The purpose of this symposium is to continue this necessary and productive interaction. [unreadable] [unreadable] [unreadable]..