electrophysiology

Summary

Top Publications

  1. doi Human brain mapping: hemodynamic response and electrophysiology
    Hiroshi Shibasaki
    Takeda General Hospital, Ishida, Fushimi ku, Kyoto 601 1495, Japan
    Clin Neurophysiol 119:731-43. 2008
  2. pmc Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
    Lindsey L Glickfeld
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 12:21-3. 2009
  3. pmc Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant
    Irene Frischauf
    Institute of Biophysics, University of Linz, A 4040 Linz, Austria
    J Biol Chem 284:21696-706. 2009
  4. ncbi Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    R Bourtchuladze
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:59-68. 1994
  5. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  6. ncbi A synaptic model of memory: long-term potentiation in the hippocampus
    T V Bliss
    Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
    Nature 361:31-9. 1993
  7. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
  8. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
  9. ncbi Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    Georg Nagel
    Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt, Germany
    Curr Biol 15:2279-84. 2005
  10. ncbi Mechanisms of gamma oscillations in the hippocampus of the behaving rat
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Neuron 37:311-22. 2003

Research Grants

  1. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
  2. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
  3. High-Speed, Depth-Resolved Images of Cardiac physiology
    Guy Salama; Fiscal Year: 2007
  4. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
  5. SAMI FOUAD NOUJAIM; Fiscal Year: 2014
  6. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
  7. Laura L Dugan; Fiscal Year: 2014
  8. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
  9. BRIAN JAMES MICKEY; Fiscal Year: 2015
  10. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013

Detail Information

Publications372 found, 100 shown here

  1. doi Human brain mapping: hemodynamic response and electrophysiology
    Hiroshi Shibasaki
    Takeda General Hospital, Ishida, Fushimi ku, Kyoto 601 1495, Japan
    Clin Neurophysiol 119:731-43. 2008
    ....
  2. pmc Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
    Lindsey L Glickfeld
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 12:21-3. 2009
    ....
  3. pmc Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant
    Irene Frischauf
    Institute of Biophysics, University of Linz, A 4040 Linz, Austria
    J Biol Chem 284:21696-706. 2009
    ..A combined approach of electrophysiology and Foerster resonance energy transfer microscopy uncovered a general mechanism in the communication of ..
  4. ncbi Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    R Bourtchuladze
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:59-68. 1994
    ..However, paired-pulse facilitation and posttetanic potentiation are normal. These results implicate CREB-dependent transcription in mammalian long-term memory...
  5. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo...
  6. ncbi A synaptic model of memory: long-term potentiation in the hippocampus
    T V Bliss
    Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
    Nature 361:31-9. 1993
    ....
  7. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers...
  8. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
  9. ncbi Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    Georg Nagel
    Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt, Germany
    Curr Biol 15:2279-84. 2005
    ..Thus, specific neurons or muscles expressing ChR2 can be quickly and reversibly activated by light in live and behaving, as well as dissected, animals...
  10. ncbi Mechanisms of gamma oscillations in the hippocampus of the behaving rat
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Neuron 37:311-22. 2003
    ..CA3 pyramidal neurons discharged CA3 and CA1 interneurons at latencies indicative of monosynaptic connections. Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which entrains the CA1 region via its interneurons...
  11. pmc Driving fast-spiking cells induces gamma rhythm and controls sensory responses
    Jessica A Cardin
    McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
    Nature 459:663-7. 2009
    ..Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation...
  12. ncbi Molecular physiology of low-voltage-activated t-type calcium channels
    Edward Perez-Reyes
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Physiol Rev 83:117-61. 2003
    ..The Cav3 subtypes can be differentiated by their kinetics and sensitivity to block by Ni2+. The goal of this review is to provide a comprehensive description of T-type currents, their distribution, regulation, pharmacology, and cloning...
  13. ncbi The molecular basis of odor coding in the Drosophila antenna
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell 117:965-79. 2004
    ..Receptors vary widely in their breadth of tuning, and odorants vary widely in the number of receptors they activate. Together, these properties provide a molecular basis for odor coding by the receptor repertoire of an olfactory organ...
  14. pmc In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2
    Benjamin R Arenkiel
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 54:205-18. 2007
    ....
  15. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  16. ncbi Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
    Imre Vida
    Anatomisches Institut, Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Neuron 49:107-17. 2006
    ..Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain...
  17. ncbi Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli
    Mark A Ungless
    Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Science 303:2040-2. 2004
    ..The identified dopamine neurons were inhibited by the aversive stimulus. These findings suggest that dopamine neurons are specifically excited by reward and that a population of nondopamine neurons is excited by aversive stimuli...
  18. pmc A cortical region consisting entirely of face-selective cells
    Doris Y Tsao
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 311:670-4. 2006
    ..Almost all (97%) of the visually responsive neurons in this region were strongly face selective, indicating that a dedicated cortical area exists to support face processing in the macaque...
  19. ncbi Diversity and dynamics of dendritic signaling
    M Hausser
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Science 290:739-44. 2000
    ..In this way, diversity in dendritic signaling allows individual neurons to carry out specialized functions within their respective networks...
  20. pmc Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors
    Valerie B Caraiscos
    Institute of Medical Science, Department of Anesthesia, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:3662-7. 2004
    ....
  21. ncbi Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
    J H Morais Cabral
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York 10021, USA
    Cell 95:649-55. 1998
    ..The presence of the domain attached to the channel slows the rate of deactivation. Given the roles of PAS domains in biology, we propose that the HERG N-terminal domain has a regulatory function...
  22. ncbi A new cellular mechanism for coupling inputs arriving at different cortical layers
    M E Larkum
    Abt Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    Nature 398:338-41. 1999
    ....
  23. doi High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
    John Dunlop
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    Nat Rev Drug Discov 7:358-68. 2008
    ..target class, which is in large part due to the labour-intensive and low-throughput nature of patch-clamp electrophysiology. This Review provides an update on the current state-of-the-art for the various automated electrophysiology ..
  24. pmc Integrated allosteric model of voltage gating of HCN channels
    C Altomare
    Dipartimento di Fisiologia e Biochimica Generali, Via Celoria 26, , Via Celoria 16, 20133 Milano, Italy
    J Gen Physiol 117:519-32. 2001
    ..HCN voltage gating thus involves two processes: voltage sensor gating and allosteric opening/closing...
  25. ncbi Multiple neural spike train data analysis: state-of-the-art and future challenges
    Emery N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Division of Health Sciences and Technology, Harvard Medical School, Boston, 02114, USA
    Nat Neurosci 7:456-61. 2004
    ..Here we review statistical methods for the analysis of multiple neural spike-train data and discuss future challenges for methodology research...
  26. ncbi Interpreting the BOLD signal
    Nikos K Logothetis
    Max Planck Institut für biologische Kybernetik, Tubingen, Germany
    Annu Rev Physiol 66:735-69. 2004
    ..We conclude with a discussion of how to use the BOLD signal to make inferences about the neural signal...
  27. pmc Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo
    Tanjew Dittgen
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 101:18206-11. 2004
    ..This approach is ideally suited for analysis of gene functions in individual neurons in the intact brain...
  28. ncbi The metabolic cost of neural information
    S B Laughlin
    Department of Zoology, University of Cambridge, UK
    Nat Neurosci 1:36-41. 1998
    ..Therefore, in noise-limited signaling systems, a weak pathway of low capacity transmits information more economically, which promotes the distribution of information among multiple pathways...
  29. ncbi Emerging issues of connexin channels: biophysics fills the gap
    A L Harris
    Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
    Q Rev Biophys 34:325-472. 2001
    ..However, the relation between these two mechanisms are unexplored, as are specific mechanisms of direct endogenous regulation of connexin channel activity. (ABSTRACT TRUNCATED)..
  30. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
    ..These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain...
  31. ncbi Synaptic mechanisms of forward suppression in rat auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 47:437-45. 2005
    ....
  32. ncbi Practising orientation identification improves orientation coding in V1 neurons
    A Schoups
    Laboratorium voor Neuro en Psychofysiologie, K U Leuven Medical School, B 3000 Leuven, Belgium
    Nature 412:549-53. 2001
    ..No modifications of the tuning curve were observed for orientations for which the monkey had not been trained. Thus training induces a specific and efficient increase in neuronal sensitivity in V1...
  33. pmc Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
    Christopher J Benson
    Department of Internal Medicine and Psychiatry, and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:2338-43. 2002
    ..These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons...
  34. ncbi Large-scale recording of neuronal ensembles
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 7:446-51. 2004
    ....
  35. pmc CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
    Paola Vergani
    Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, New York 10021, USA
    Nature 433:876-80. 2005
    ..This establishes a molecular mechanism, involving dynamic restructuring of the NBD dimer interface, that is probably common to all members of the ABC protein superfamily...
  36. ncbi Biological pattern generation: the cellular and computational logic of networks in motion
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Neuron 52:751-66. 2006
    ..In addition, I will outline the utility of computational models in analysis of the dynamic actions of these motor networks...
  37. ncbi Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
    H Christian Peters
    Institut für Neurale Signalverarbeitung, Zentrum fur Molekulare Neurobiologie Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Nat Neurosci 8:51-60. 2005
    ..M channels are thus critical determinants of cellular and neuronal network excitability, postnatal brain development and cognitive performance...
  38. ncbi The 5-HT3B subunit is a major determinant of serotonin-receptor function
    P A Davies
    Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    Nature 397:359-63. 1999
    ..In addition to providing a new target for therapeutic agents, the 5-HT3B subunit will be a valuable resource for defining the molecular mechanisms of ion-channel function...
  39. pmc A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
    Shao Jun Tang
    California Institute of Technology, Howard Hughes Medical Institute, Division of Biology 216 76, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:467-72. 2002
    ..The localization of this translational signaling pathway at postsynaptic sites may provide a mechanism that controls local protein synthesis at potentiated synapses...
  40. ncbi Fast and slow contrast adaptation in retinal circuitry
    Stephen A Baccus
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuron 36:909-19. 2002
    ..Slow adaptation did not affect kinetics, but produced a gradual hyperpolarization. This hyperpolarization can account for slow adaptation in the spiking output of ganglion cells...
  41. ncbi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    Nature 421:844-8. 2003
    ..We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner...
  42. ncbi Functional conservation of an insect odorant receptor gene across 250 million years of evolution
    Walton D Jones
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Curr Biol 15:R119-21. 2005
    ..The medical and economic impact of these animals can be ascribed in part to the sensitivity and selectivity of their olfactory systems, essential for location of their preferred plant and animal hosts...
  43. ncbi Internal dynamics determine the cortical response to thalamic stimulation
    Jason N MacLean
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Neuron 48:811-23. 2005
    ..Our data demonstrate that precise spatiotemporal activity patterns can be triggered by thalamic inputs and indicate that the thalamus serves to release intrinsic cortical dynamics...
  44. pmc KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging
    Karen Ocorr
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:3943-8. 2007
    ..That arrhythmias in both WT and KCNQ1 mutants become worse as flies age suggests that additional factors are also involved...
  45. pmc Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance
    Sean M Montgomery
    Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA
    Proc Natl Acad Sci U S A 104:14495-500. 2007
    ..Based on these findings, we propose that gamma oscillations may serve as a physiological mechanism by which CA3 output can coordinate CA1 activity to support retrieval of hippocampus-dependent memories...
  46. doi Insect odorant receptors are molecular targets of the insect repellent DEET
    Mathias Ditzen
    Laboratory of Neurogenetics and Behavior, Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065 USA
    Science 319:1838-42. 2008
    ..The identification of candidate molecular targets for the action of DEET may aid in the design of safer and more effective insect repellents...
  47. pmc The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    J Physiol 577:907-24. 2006
    ..We conclude that reliable physiological criteria for VTA DA neuron identification have yet to be determined, and that the criteria currently being used are unreliable...
  48. doi Ephaptic coupling of cortical neurons
    Costas A Anastassiou
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:217-23. 2011
    ..Our findings indicate that endogenous brain activity can causally affect neural function through field effects under physiological conditions...
  49. ncbi Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells
    K D Harris
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 32:141-9. 2001
    ....
  50. ncbi Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo
    Sooyoung Chung
    Department of Biology and, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 34:437-46. 2002
    ..These data strongly suggest that synaptic depression of thalamic input to the cortex contributes to the dynamic regulation of neuronal sensitivity during rapid changes in sensory input...
  51. ncbi Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
    Kenichi Ohki
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 433:597-603. 2005
    ..These results indicate that cortical maps can be built with single-cell precision...
  52. ncbi Modulation of oscillatory neuronal synchronization by selective visual attention
    P Fries
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
    Science 291:1560-3. 2001
    ..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex...
  53. ncbi Olfaction: mosquito receptor for human-sweat odorant
    Elissa A Hallem
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 427:212-3. 2004
    ..Compounds designed to activate or block receptors of this type could function as attractants for trapping mosquitoes or as insect repellents in helping to control Anopheles and other insect pests...
  54. pmc Electrophysiology and brain imaging of biological motion
    Aina Puce
    Centre for Advanced Imaging, Department of Radiology, West Virginia University, PO Box 9236, Morgantown 26506 9236, USA
    Philos Trans R Soc Lond B Biol Sci 358:435-45. 2003
    ....
  55. pmc Local origin of field potentials in visual cortex
    Steffen Katzner
    Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
    Neuron 61:35-41. 2009
    ..This quantitative estimate indicates that LFPs are more local than often recognized and provides a guide to the interpretation of the increasing number of studies that rest on LFP recordings...
  56. ncbi Excitatory actions of GABA in the cortex
    Allan T Gulledge
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Mills Road, Canberra, ACT 0200, Australia
    Neuron 37:299-309. 2003
    ..Our findings demonstrate that under certain circumstances GABA will have an excitatory role in synaptic integration in the cortex...
  57. pmc The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
    Laiche Djouhri
    Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
    J Physiol 550:739-52. 2003
    ..Thus high levels of Nav1.8 protein may contribute to the longer AP durations (especially in A-fibre neurons) and larger AP overshoots that are typical of nociceptors...
  58. pmc Pannexins, a family of gap junction proteins expressed in brain
    Roberto Bruzzone
    Department of Clinical Neurobiology, Interdisciplinary Center for Neurosciences, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:13644-9. 2003
    ....
  59. pmc Allosteric control of an ionotropic glutamate receptor with an optical switch
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Chem Biol 2:47-52. 2006
    ..Our device has potential uses not only in biology but also in bioelectronics and nanotechnology...
  60. doi Electrophysiology in the age of light
    Massimo Scanziani
    Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nature 461:930-9. 2009
    b>Electrophysiology, the 'gold standard' for investigating neuronal signalling, is being challenged by a new generation of optical probes...
  61. ncbi Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels
    K J Swartz
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 18:675-82. 1997
    ..These results suggest that residues near the outer edges of S3 and S4 form the HaTx binding sites and are eccentrically located at least 15 A from the central pore axis on the surface of voltage-gated K+ channels...
  62. ncbi Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture
    Angel Barco
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 108:689-703. 2002
    ..Our analysis indicates that synaptic capture of CRE-driven gene products may be sufficient for consolidation of LTP and provides insight into the molecular mechanisms of synaptic tagging and synapse-specific potentiation...
  63. ncbi Initiation, propagation, and termination of epileptiform activity in rodent neocortex in vitro involve distinct mechanisms
    David J Pinto
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 25:8131-40. 2005
    ..These results suggest that the phenomenological stages of epileptiform events correspond to distinct mechanistic stages...
  64. ncbi The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel
    Tania Ferrer
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 94113, USA
    J Biol Chem 281:12858-64. 2006
    ..Moreover, rather than functioning simply as a mechanical lever, these findings imply that specific interactions between the S4-S5 linker and the activation gate stabilize the closed channel conformation...
  65. ncbi The effect of correlated variability on the accuracy of a population code
    L F Abbott
    Volen Center, Brandeis University, Waltham MA 02254, USA
    Neural Comput 11:91-101. 1999
    ..Furthermore, in some cases, but not all, correlations improve the accuracy of a population code...
  66. ncbi KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
    B C Schroeder
    Zentrum fur Molekulare Neurobiologie Hamburg, Hamburg University, Martinistrasse 85, D 20246 Hamburg, Germany
    J Biol Chem 275:24089-95. 2000
    ..A KCNQ5 splice variant found in skeletal muscle displays altered gating kinetics. This indicates a molecular diversity of channels yielding M-type currents and suggests a role for KCNQ5 in the regulation of neuronal excitability...
  67. ncbi Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:13569-77. 2002
    ..We concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel...
  68. ncbi Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury
    Bryan C Hains
    Department of Neurology and Paralyzed Veterans of America Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 23:8881-92. 2003
    ..3 expression and neuronal hyperexcitability associated with central neuropathic pain...
  69. ncbi Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels
    J Platzer
    Institut fur Biochemische Pharmakologie, Innsbruck, Austria
    Cell 102:89-97. 2000
    ..We conclude that alpha1D can form LTCCs with negative activation thresholds essential for normal auditory function and control of cardiac pacemaker activity...
  70. ncbi Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin
    Giedrius Gaudesius
    Department of Physiology, University of Bern, Switzerland
    Circ Res 93:421-8. 2003
    ..This synchronization is accompanied by extremely large local conduction delays, which might contribute to the generation of arrhythmias in fibrotic hearts...
  71. ncbi Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons
    Candice C Askwith
    Department of Internal Medicine, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:18296-305. 2004
    ..These findings indicate that the absolute and relative amounts of ASIC subunits determine the amplitude and properties of hippocampal H(+)-gated currents and therefore may contribute to normal physiology and pathophysiology...
  72. ncbi Applications of random field theory to electrophysiology
    James M Kilner
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Neurosci Lett 374:174-8. 2005
    ..Here, by analysing the time-frequency decompositions of single channel EEG data we show that RFT adjustments can be used in the analysis of electrophysiological data and illustrate the advantages of this method over existing approaches...
  73. pmc Fast and slow oscillations in human primary motor cortex predict oncoming behaviorally relevant cues
    Maryam Saleh
    Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Neuron 65:461-71. 2010
    ..This result suggests that the beta amplitude and delta phase in MI reflect the subject's engagement with the rhythmically presented cues and work together to enhance sensitivity to predictable and task-relevant visual cues...
  74. ncbi A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX
    S Couturier
    Department of Biochemistry, University of Geneva, Switzerland
    Neuron 5:847-56. 1990
    ..A bacterial fusion protein encompassing residues 124-239 of alpha 7 binds labeled alpha-bungarotoxin. We conclude that alpha-bungarotoxin binding proteins in the vertebrate nervous system can function as nAChRs...
  75. ncbi In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex
    T H Schwartz
    Max Planck Institut fur Neurobiologie, München Martinsried, Germany
    Nat Med 7:1063-7. 2001
    ..Optical mapping of epilepsy might be a useful adjunct in the surgical treatment of neocortical epilepsy, which critically depends on the precise localization of intrinsically epileptogenic neurons...
  76. pmc Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine
    Yunlei Yang
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 100:15194-9. 2003
    ..By providing extracellular D-serine that facilitates activation of NMDA receptors, astrocytes thus play a key role in long-term synaptic plasticity...
  77. pmc Target cell-specific modulation of transmitter release at terminals from a single axon
    M Scanziani
    Laboratoire de Physiologie, Ecole Superieure de Physique et Chimie Industrielles, F 75231 Paris, France
    Proc Natl Acad Sci U S A 95:12004-9. 1998
    ..On the basis of these results, we conclude that the pharmacological and physiological properties of presynaptic terminals are determined, at least in part, by the target cells...
  78. ncbi An ultra-sparse code underlies the generation of neural sequences in a songbird
    Richard H R Hahnloser
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
    Nature 419:65-70. 2002
    ....
  79. ncbi Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons
    Chao Ma
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurophysiol 89:1588-602. 2003
    ....
  80. pmc The spine neck filters membrane potentials
    Roberto Araya
    Howard Hughes Medical Institute and Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 103:17961-6. 2006
    ..We conclude that the spine neck plays an electrical role in the transmission of membrane potentials, isolating synapses electrically...
  81. ncbi Integrating electrophysiology and neuroimaging of spatial selective attention to simple isolated visual stimuli
    G R Mangun
    Center for Cognitive Neuroscience, Duke University, Box 90999, Durham, NC 27708, USA
    Vision Res 41:1423-35. 2001
    ....
  82. ncbi Attention-like processes in Drosophila require short-term memory genes
    Bruno van Swinderen
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 315:1590-3. 2007
    ..These processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga. Attention defects in these mutants were associated with distinct optomotor effects in behavioral assays...
  83. ncbi Structure and regulation of voltage-gated Ca2+ channels
    W A Catterall
    Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195 7280, USA
    Annu Rev Cell Dev Biol 16:521-55. 2000
    ....
  84. ncbi Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach
    Laura Sartiani
    Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, University of Firenze, Firenze, Italy
    Stem Cells 25:1136-44. 2007
    ..In summary, human embryonic stem cell-derived cardiomyocytes mature over time during in vitro differentiation, approaching an adult phenotype. Disclosure of potential conflicts of interest is found at the end of this article...
  85. ncbi General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel
    L J Brunet
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 17:681-93. 1996
    ..Our results provide direct evidence that the CNG channel subserves excitatory olfactory signal transduction, and further suggest that cAMP is the sole second messenger mediating this process...
  86. pmc Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, Division of Cardiology, Department of Medicine, University of Utah, Salt Lake City, UT 84112
    J Physiol 514:667-75. 1999
    ..5. The results indicate that the S4-S5 linker is a crucial component of the activation gate of HERG channels...
  87. ncbi The dynamic clamp comes of age
    Astrid A Prinz
    Volen Center and Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
    Trends Neurosci 27:218-24. 2004
    ....
  88. pmc Novelty acquisition is associated with induction of hippocampal long-term depression
    D Manahan-Vaughan
    Leibniz Institute for Neurobiology, Departments of Neurophysiology, Magdeburg, Germany
    Proc Natl Acad Sci U S A 96:8739-44. 1999
    ..Behavioral comparison between the first and second environmental exposure confirmed that the animals had habituated to the novel environment. These observations strongly implicate an association between novelty acquisition and LTD...
  89. ncbi Spatio-temporal dynamics of odor representations in the mammalian olfactory bulb
    Hartwig Spors
    The Department of Neurobiology, Weizmann Institute of Science, 76100, Rehovot, Israel
    Neuron 34:301-15. 2002
    ..Our data show that in the mammalian olfactory bulb, odor identity and concentration are represented by spatio-temporal patterns, rather than spatial patterns alone...
  90. ncbi Ion channel properties underlying axonal action potential initiation in pyramidal neurons
    Costa M Colbert
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, Texas 77204 5513, USA
    Nat Neurosci 5:533-8. 2002
    ....
  91. doi Patches with links: a unified system for processing faces in the macaque temporal lobe
    Sebastian Moeller
    Institute for Brain Research and Center for Advanced Imaging, University of Bremen, Post Office Box 330440, D 28334 Bremen, Germany
    Science 320:1355-9. 2008
    ..Stimulation outside the face patches produced an activation pattern that spared the face patches. These results suggest that the face patches form a strongly and specifically interconnected hierarchical network...
  92. ncbi Store-operated calcium channels
    Anant B Parekh
    Department of Physiology, University of Oxford, United Kingdom
    Physiol Rev 85:757-810. 2005
    ....
  93. ncbi Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons
    Nathaniel T Blair
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 20114, USA
    J Neurosci 22:10277-90. 2002
    ....
  94. ncbi Information processing in the axon
    Dominique Debanne
    Equipe INSERM AVENIR, Plasticité de l excitabilité neuronale, Neurobiologie des Canaux Ioniques INSERM U641, Institut Federatif de Recherche Jean Roche, Universite de la Mediterranee, Marseille, France
    Nat Rev Neurosci 5:304-16. 2004
  95. ncbi Functional organization of ferret auditory cortex
    Jennifer K Bizley
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    Cereb Cortex 15:1637-53. 2005
    ..The presence of both tonotopic and non-tonotopic auditory cortical fields indicates that the organization of ferret auditory cortex is comparable to that seen in other mammals...
  96. pmc Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin
    Xiang Li
    Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 102:17816-21. 2005
    ..Thus light-activated vertebrate RO4 and green algae ChR2 allow the antagonistic control of neuronal function within ms to s in a precise, reversible, and noninvasive manner in cultured neurons and intact vertebrate spinal cords...
  97. doi Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation
    Zenawit Girmatsion
    Division of Cardiology, Goethe University, Frankfurt, Germany
    Heart Rhythm 6:1802-9. 2009
    ..MicroRNA-1 (miR-1) reciprocally regulates inwardly rectifying potassium channel (Kir)2.1 expression in coronary disease, contributing to arrhythmogenesis...
  98. pmc Identified GnRH neuron electrophysiology: a decade of study
    Suzanne M Moenter
    Department of Molecular and Integrative Physiology, 7725 Med Sci II, 1301 E Catherine St, Ann Arbor, MI 48109 5622, USA
    Brain Res 1364:10-24. 2010
    ..Advances in our understanding of neuromodulation of GnRH neurons and synchronization of this network are also discussed...
  99. pmc Electromagnetic field effect or simply stress? Effects of UMTS exposure on hippocampal longterm plasticity in the context of procedure related hormone release
    Nora Prochnow
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 6:e19437. 2011
    ....
  100. ncbi Learning to see: experience and attention in primary visual cortex
    R E Crist
    The Rockefeller University, New York, New York 10021, USA
    Nat Neurosci 4:519-25. 2001
    ..Furthermore, this property showed task dependence, only being manifest when the animal was performing the trained discrimination...
  101. ncbi Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers
    Tian Xue
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Circulation 111:11-20. 2005
    ..Although CMs can be derived from hESCs ex vivo, it remains uncertain whether a functional syncytium can be formed between donor and recipient cells after engraftment...

Research Grants82

  1. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
    ..Preliminary data suggest a strong suppressive effect of microdialysis-applied 8-OH-DPAT on state-related discharge activity of the dorsal raphe nucleus, and we will also investigate the effects of 5HT1A antagonists. ..
  2. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    ..with the major advantage that they still allow minimally invasive multi-modality measurements of electrophysiology, oximetry and flow...
  3. High-Speed, Depth-Resolved Images of Cardiac physiology
    Guy Salama; Fiscal Year: 2007
    ..will administer the BRP, develop the instrument and apply the new technology to problems in cardiac electrophysiology, that remain unresolved due to a lack of 3-D information. Drs...
  4. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..concepts and techniques in structural and molecular biology, which I will add to my background in cardiac electrophysiology. My long term career objective is to be an independent scientist, and to investigate structural, functional ..
  5. SAMI FOUAD NOUJAIM; Fiscal Year: 2014
    ..concepts and techniques in structural and molecular biology, which I will add to my background in cardiac electrophysiology. My long term career objective is to be an independent scientist, and to investigate structural, functional ..
  6. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..We will combine strategies from molecular biology, cell physiology, biochemistry, electrophysiology and confocal microscopy to accomplish our scientific goals...
  7. Laura L Dugan; Fiscal Year: 2014
    ..including live animal fluorescence imaging of Nox2 activity, EPR, confocal imaging, immuno-fluorescence, electrophysiology and behavioral testing of brain region-specific function (e.g...
  8. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..Our experiments utilize a combination of whole cell patch clamp electrophysiology, tract tracing with fluorogold and pseudorabies virus, ultrastructural immunocytochemistry, and altered gene ..
  9. BRIAN JAMES MICKEY; Fiscal Year: 2015
    ..For his thesis project, he employed electrophysiology and computational techniques to study activity in the cerebral cortex that underlies sound perception, and ..
  10. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..We propose to use a variety of techniques including biochemistry, immunolabeling, live-imaging, electrophysiology and behavioral tests, because a multidisciplinary approach will comprehensively test our model...
  11. MARK REID PHILIPS; Fiscal Year: 2015
    ..We will characterize both structurally (protein-protein interactions) and functionally (electrophysiology) the molecular interactions between phospho-K-Ras, Bcl-XL and IP3R...
  12. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..g. immunocytochemistry, real-time PCR, Western blot, patch-clamp electrophysiology, isolated coronary microvessels) and in vivo (studies in conscious, chronically instrumented and ..
  13. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..While I have gained invaluable skills using electrophysiology, immunohistochemistry, confocal microscopy, and stereotactic surgery to address key questions, I have little ..
  14. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..Channel function will be assessed by pressure myography in isolated arteries and patch clamp electrophysiology in isolated myocytes...
  15. Heather R Burkin; Fiscal Year: 2015
    ..In 2003 I received brief postdoctoral training in basic electrophysiology. I took a break from research between 2004 and 2009 to raise two children...
  16. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..In 2003 I received brief postdoctoral training in basic electrophysiology. I took a break from research between 2004 and 2009 to raise two children...
  17. Haoxing Xu; Fiscal Year: 2016
    ..To expand our findings, the goal of the proposed research is to apply a multidisciplinary approach using electrophysiology, Ca2+ imaging, immunochemistry, biochemistry, and fluorescence imaging to test our central hypotheses that ..
  18. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..of psoriasis and psoriatic arthritis using a combination of immunohistochemistry, flow cytometry and electrophysiology studies. To further substantiate the pathologic role of Kv1...
  19. April N Herrity; Fiscal Year: 2014
    ..Evidence from anatomical tracing studies as well as preliminary electrophysiology recordings from our lab indicates that the bladder and colon are not only innervated by spinal afferents, ..
  20. CHRISTOPHER KIRK THOMPSON; Fiscal Year: 2014
    ..via electroporation, time-lapse 2-photon imaging, neuronal reconstruction and structural analysis, electrophysiology and quantification of thyroid hormone levels...
  21. Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium as a Model for A
    Alfred S Lewin; Fiscal Year: 2013
    ..experiments: (1) We will monitor the time course of retinal degeneration in real time in living mice using electrophysiology (ERG), high resolution structural analysis (SD-OCT) and behavioral analysis (Optomotry)...
  22. Jian Yang; Fiscal Year: 2015
    ..hemi-channels, using a combination of biochemistry, proteomics, fixed cell and live cell imaging, and electrophysiology. As intracellular calcium signaling is severely altered in aging neurons and age-related neurodegenerative ..
  23. Developmental Programs of Neural Circuits in the Mouse Medial Hypothalamus
    Holly A Ingraham; Fiscal Year: 2013
    ..e. electrophysiology)...
  24. Teresa M Buck; Fiscal Year: 2015
    ..I am extremely motivated to master two- electrode voltage clamp electrophysiology, which will allow me to monitor ENaC trafficking using a functional readout...
  25. David X Zhang; Fiscal Year: 2016
    ..on isolated HCA and cultured endothelial cells using an integrated approach incorporating molecular biology, electrophysiology and fluorescence/electron imaging techniques with in vitro assessment of vessel reactivity...
  26. Michael K Georgieff; Fiscal Year: 2015
    ..fetal and early postnatal life affects the genome, metabolome, structure, intracellular signaling pathways, electrophysiology and specific behavioral functions of the developing hippocampus...
  27. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ..Studer), 2) cortical interneuron development (PI-Dr. Anderson), 3) electrophysiology in forebrain slices (Co-Investigator Dr...
  28. Yan Zhang; Fiscal Year: 2016
    ..Sheldon Miller (NEI/NIH), who are experts in RPE physiology and electrophysiology, and Professor Kunxin Luo (UC Berkeley), whose research focus is the TGF-[unreadable] family including BMPs ..
  29. Samay Jain; Fiscal Year: 2015
    ..for R01 funding establishing a foundation to become a leader in clinical research with a sustainable plan to apply autonomic electrophysiology to the diagnosis and treatment of PD as well as understanding mechanisms which underlie PD.
  30. Bjorn C Knollmann; Fiscal Year: 2016
    ..effects of sarcomeric mutations in rabbits to test the hypothesis in a model with more human-like cardiac electrophysiology. AIM 1: To determine the effect of myofilament Ca2+ sensitization on cardiac Ca2+ handling AIM 2: To ..
  31. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2011
    ..Using quantitative fluorescence microscopy and electrophysiology, our laboratory was the first to demonstrate that Epo modulates the intracellular calcium concentration ([..
  32. Liya Qiao; Fiscal Year: 2016
    ..This will be done at the molecular (mRNA and protein) and functional (intracellular Ca2+ recording and electrophysiology) levels...
  33. Mechanism and functional role of AKAP79/150 in M current control and excitability
    Mark S Shapiro; Fiscal Year: 2010
    ..energy transfer (FRET), total internal reflection fluorescence (TIRF), confocal microscopy, patch-clamp electrophysiology, carbon-fiber amperometry and video imaging...
  34. ClC-3 Chloride Ion Channels in Vascular Smooth Muscle
    Fred Lamb; Fiscal Year: 2009
    ..As we establish the functional relationship between ClC-3 and Nox1, we will be defining the electrophysiology of a completely novel intracellular compartment, the ROS signaling endosome...
  35. JOHN PEARCE MORROW; Fiscal Year: 2015
    ..I will gain in-depth experience in the areas of biochemistry, gene regulation, cellular electrophysiology, and in vivo physiology as applied to animal models of heart failure and arrhythmias. Dr...
  36. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..These are: 1) correlation of cellular activity and peptide action with behaviors by imaging and electrophysiology, 2) driving ensembles using overexpression of ETH receptor subtypes and cell-specific activation with ..
  37. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..inhibitors enhance glutamate release from presynaptic terminals in the hippocampus, using patch clamp electrophysiology and FM dye technique...
  38. Mark E Pennesi; Fiscal Year: 2015
    ..thirty-five years of experience with inherited retinal degenerations as well as a vast knowledge of clinical electrophysiology. Dr...
  39. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..The proposal has three aims: the first is to look at the electrophysiology in these targeted deletion mutants;specifically looking at cAMP-, and PKA-dependent, and PKA-independent LTP ..
  40. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..Using a combination of classical medicinal chemistry and automated and manual electrophysiology we intend to further explore the structure activity relationship around SKA 31 and EBIO in order to improve ..
  41. Joseph Y Cheung; Fiscal Year: 2014
    ..in adult rat myocytes, transfected HEK293 cells, and PLM knockout (KO) mice), and different techniques (electrophysiology, biochemistry, radioactive tracer uptake, and site-directed mutagenesis), we have unequivocally established ..
  42. J Kevin Foskett; Fiscal Year: 2016
    ..Using nuclear patch clamp electrophysiology, we found that these interactions profoundly alter gating of the channels, sensitizing them to low [InsP3] ..
  43. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..are that metabolic factors play a role in heart disease through their tight interrelationship with cardiac electrophysiology (CEP) and that identification of the above-mentioned phenomena will strengthen our mechanistic understanding ..
  44. STEVEN SIMON SCHERER; Fiscal Year: 2016
    ..be investigated - by immunostaining, scrape loading, fluorescence recovery after photobleaching (FRAP), and electrophysiology. Whether the dominant mutants have dominant-negative effects on WT Cx47 will also be investigated (by co-..
  45. Modulation of insulin and glucagon secretion by GPCR ligands
    TARA ASHLEY SCHWETZ; Fiscal Year: 2011
    ..The proposed experiments combine novel and conventional imaging and electrophysiology techniques to address the aims. The use of a transgenic mouse model permits definitive ...
  46. Circadian Rhythm in Cone Photoreceptors: Cellular Mechanisms
    GLADYS Y KO; Fiscal Year: 2012
    ..Combinations of bioinformatics analysis, electrophysiology, molecular / biochemical assays, and advanced high resolution microscopy will be used to investigate the ..
  47. Bertil Hille; Fiscal Year: 2016
    ..The methodology will involve single-cell biophysics, electrophysiology, fluorescence resonance energy transfer, photometry, molecular biology, and confocal microscopy...
  48. Scott C Steffensen; Fiscal Year: 2016
    ..responses, total charge transfer, AMPAR/NMDAR ratio and AMPA rectification index using patch clamp electrophysiology. These studies will be accomplished by recording IPSCs and EPSCs from brain slices during withdrawal from a ..
  49. Victor L Arvanian; Fiscal Year: 2016
    ..synaptic connections through the injury epicenter to lumbar motoneurons, and then to hindlimb muscles (electrophysiology);(2) anatomical plasticity of fibers accounting for the persistence of the synaptic response after exposure ..
  50. Mriganka Sur; Fiscal Year: 2016
    ..Third, we will measure functional synapse maturation and circuit plasticity through intracellular electrophysiology in vitro and optical imaging of visual cortex in vivo during experience-dependent plasticity...
  51. Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells
    Michael X Zhu; Fiscal Year: 2012
    ..heterologous expression and site-directed mutagenesis), biochemistry (protein-protein interactions), electrophysiology (whole-cell and single channel recordings), and genetic approaches (transgenic mice that express defined ..
  52. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..Hippocampal slice electrophysiology combined with pharmacological agents and lentiviral vectors will then define how SE-induced alterations in ..
  53. NIH Director's Pioneer Award
    Karl Deisseroth; Fiscal Year: 2009
    ..abstract_text> ..
  54. Donald M Caspary; Fiscal Year: 2016
    ..b>Electrophysiology will attempt to determine the impact of aging on the ability of brain cells in this area to process acoustic ..
  55. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2013
    ..A multidisciplinary approach employing molecular biology, biochemistry, pharmacology, cell biology, and electrophysiology will be used to accomplish the two specific aims...
  56. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..Doppler flowmetry, measurements of CGRP release, fluorescence imaging of intracellular calcium, cellular electrophysiology, biochemistry, gene knock-out mice for TRPA1 or TRPV1, and pharmacological and molecular interference to ..
  57. Craig Montell; Fiscal Year: 2016
    ..To address these questions, we propose to employ a combination of genetics, electrophysiology, cell biology, germline transformation and biochemical approaches...
  58. Viktor Yarotskyy; Fiscal Year: 2015
    ..The applicant has outstanding skills and great expertise in electrophysiology and biophysics, but lacks essential in-depth training in other key components required for a successful ..
  59. Helen M Bramlett; Fiscal Year: 2014
    ..and chronic (12 wks and 1 yr) seizure susceptibility using clinically relevant outcome measures including electrophysiology and cognitive assessment will be determined...
  60. SK channels: Roles and mechanisms for dendritic excitability and plasticity
    James G Maylie; Fiscal Year: 2012
    ..these hypotheses by using an integrated, diverse technical repertoire including immuno electron microscopy, electrophysiology, SK transgenic mice, heterologous co-expression studies, and western and biochemical analysis...
  61. Preoptic histamine signaling in thermoregulation and energy expenditure
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2012
    ..The receptor subtypes involved will be studied in Specific Aim2 which will use pharmacological tools, electrophysiology, and single cell RT- PCR...
  62. Michael Regnier; Fiscal Year: 2015
    ..team of investigators with considerable experience in the areas of cardiac contractile function, metabolism, electrophysiology and viral-mediated gene delivery has been assembled. Dr...
  63. John J Woodward; Fiscal Year: 2016
    ..carried out during the previous funding period of this project used recombinant expression techniques and electrophysiology to study the effects of abused inhalants on ion channels widely expressed by brain neurons...
  64. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2012
    ..Intrinsic neuronal properties will be examined by extra- and intracellular electrophysiology. We will confirm the primary role of leptin deficiency in programmed hyperphagia, contrast mechanisms of ..
  65. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..modeling with application of a set of emerging techniques involving molecular biology, optics, and electrophysiology to study the cell-type specific and circuitry properties of networks that produce gamma oscillations in the ..
  66. Lisa Ostrin; Fiscal Year: 2016
    ..There, she used electrophysiology to evaluate retinal changes in legally blind patients with retinal prostheses, after which she joined the UC ..
  67. Signal transduction in TRPM5-expressing olfactory sensory neurons
    Diego Restrepo; Fiscal Year: 2010
    ..We take advantage of the fact that the expertise of the Bacigalupo laboratory in patch clamp electrophysiology is highly complementary to the expertise of the Restrepo laboratory in calcium imaging and mouse genetics...
  68. DNA Methylation Profiling of Chronic Pain
    Andreas S Beutler; Fiscal Year: 2010
    ..SNL) pain model, L4 and L5 dorsal root ganglion (DRG) neurons and glia become dysfunctional with altered electrophysiology, gene expression, and cellular plasticity. The basic molecular force underlying these alterations is unknown...
  69. Rapid High-Resolution Electroanatomical Cardiac Mapping System for the Treatment
    DORON HARLEV; Fiscal Year: 2009
    ..and safety testing in large animals and humans, the system is envisioned to be used in the cardiac electrophysiology laboratory to generate patient-specific 3D maps of the heart's chambers that delineate both anatomical ..
  70. DEVELOPMENT OF NOVEL ANTIEPILEPTIC DRUGS
    Manoj K Patel; Fiscal Year: 2010
    ..We will develop an electrophysiology screening profile using clinically used AEDs, known to target sodium channels as a mechanism of action, and ..
  71. MODEL OF DYSRHYTHMIAS AFTER CONGENITAL HEART SURGERY
    Arthur Garson; Fiscal Year: 1991
    ..chronic RV hypertrophy and chronic right ventriculotomy, and demonstrated, as postulated, normal cellular electrophysiology and no inducible VA...
  72. Micromachined 7MHz Two Dimensional Forward Looking Ultrasound Medical Penetrative
    ELI WIENER AVNEAR; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Minimal invasive electrophysiology procedures to treat cardiac arrhythmias are increasing growing in popularity, due to technological advancements in penetrative technologies, which provide enhanced ..
  73. Advanced Source Reconstruction Techniques for Fetal Magnetocardiography
    Mihai Popescu; Fiscal Year: 2009
    ..fMCG) has emerged as an attractive technique for the in-utero assessment of the fetal cardiac electrophysiology, which can offer vastly superior capabilities to those, attainable by alternative methods...
  74. MRI Compatible Electrode Catheter System
    STEVEN WEDAN; Fiscal Year: 2009
    ..that magnetic resonance imaging (MRI), with MRI-compatible diagnostic and therapeutic systems;can allow electrophysiology studies and catheter ablation to be performed without x-ray radiation...
  75. Carbon Nanopipette ElectroProbe in Cell-Electrophysiology Applications
    CHAMIKA WANSAPURA; Fiscal Year: 2009
    ..reproducible measurements of changes in membrane potential or total ionic currents will allow advancement in electrophysiology applications of single cells by replacing the conventional glass micropipette electrodes with CNP ..
  76. Instrument for Intracerebral Microinjections and Electrophysiology
    Lee Margolin; Fiscal Year: 2009
    ..The Intracerebral Microinjection Instrument proposed herein improves the ability to make such injections with minimal damage to the brain, and with minimal activation of the brains rejection mechanisms for foreign material. ..
  77. BIORAD 2-PHOTON LASER SCANNING MICROSCOPY SYSTEM
    Arnold Kriegstein; Fiscal Year: 1999
    ..of 2-photon microscopy to neurobiology will undoubtedly be realized by a combination of this technique with electrophysiology in intact brain preparations, allowing the visualization of second messenger system activity by reported ..
  78. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 2000
    ..The two specific areas of investigation will be: l) Cellular electrophysiology of human auditory cortex, 2) Feasibility studies of an auditory cortex neural prosthetic device concept...
  79. ELECTROPHYSIOLOGY OF TRANSGENIC CARDIOMYOPATHIC MICE
    Charles Berul; Fiscal Year: 2001
    ..in vivo using transgenic models, the applicants recently developed a mouse model of a complete cardiac electrophysiology (EP) study based on human clinical protocols, including responses to programmed stimulation and ..