biomechanics

Summary

Summary: The study of the application of mechanical laws and the action of forces to living structures.

Top Publications

  1. ncbi Tissue cells feel and respond to the stiffness of their substrate
    Dennis E Discher
    School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
    Science 310:1139-43. 2005
  2. ncbi ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion--Part II: shoulder, elbow, wrist and hand
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rathwell Building, Burlington, VT, USA
    J Biomech 38:981-992. 2005
  3. ncbi Action anticipation and motor resonance in elite basketball players
    Salvatore M Aglioti
    Dipartimento di Psicologia, Sapienza Universita di Roma, Via dei Marsi 78, 1 00185, Roma, Italy
    Nat Neurosci 11:1109-16. 2008
  4. ncbi Complex dental structure and wear biomechanics in hadrosaurid dinosaurs
    Gregory M Erickson
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Science 338:98-101. 2012
  5. ncbi ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion--part I: ankle, hip, and spine. International Society of Biomechanics
    Ge Wu
    J Biomech 35:543-8. 2002
  6. pmc Strength in the periphery: growth cone biomechanics and substrate rigidity response in peripheral and central nervous system neurons
    Daniel Koch
    Department of Physics, Georgetown University, Washington, DC, USA
    Biophys J 102:452-60. 2012
  7. pmc Cell mechanics and the cytoskeleton
    Daniel A Fletcher
    Bioengineering and Biophysics, University of California, Berkeley, California 94720, USA
    Nature 463:485-92. 2010
  8. ncbi Determining in vivo biomechanical properties of the cornea with an ocular response analyzer
    David A Luce
    Reichert Inc, Depew, New York, USA
    J Cataract Refract Surg 31:156-62. 2005
  9. ncbi Hip contact forces and gait patterns from routine activities
    G Bergmann
    Biomechanics Laboratory, Benjamin Frunklin School of Medicine, Free University of Berlin, Hindenburgdamm 30, 12203, Berlin, Germany
    J Biomech 34:859-71. 2001
  10. pmc Force sensing by mechanical extension of the Src family kinase substrate p130Cas
    Yasuhiro Sawada
    Department of Biological Sciences, Columbia University, Sherman Fairchild Center Room 715, MC 2416, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Cell 127:1015-26. 2006

Detail Information

Publications362 found, 100 shown here

  1. ncbi Tissue cells feel and respond to the stiffness of their substrate
    Dennis E Discher
    School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
    Science 310:1139-43. 2005
    ..The feedback of local matrix stiffness on cell state likely has important implications for development, differentiation, disease, and regeneration...
  2. ncbi ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion--Part II: shoulder, elbow, wrist and hand
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rathwell Building, Burlington, VT, USA
    J Biomech 38:981-992. 2005
    In this communication, the Standardization and Terminology Committee (STC) of the International Society of Biomechanics proposes a definition of a joint coordinate system (JCS) for the shoulder, elbow, wrist, and hand...
  3. ncbi Action anticipation and motor resonance in elite basketball players
    Salvatore M Aglioti
    Dipartimento di Psicologia, Sapienza Universita di Roma, Via dei Marsi 78, 1 00185, Roma, Italy
    Nat Neurosci 11:1109-16. 2008
    ....
  4. ncbi Complex dental structure and wear biomechanics in hadrosaurid dinosaurs
    Gregory M Erickson
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4295, USA
    Science 338:98-101. 2012
    ..Three-dimensional wear models incorporating fossilized wear properties reveal how these tissues interacted for grinding and ecological specialization...
  5. ncbi ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion--part I: ankle, hip, and spine. International Society of Biomechanics
    Ge Wu
    J Biomech 35:543-8. 2002
    The Standardization and Terminology Committee (STC) of the International Society of Biomechanics (ISB) proposes a general reporting standard for joint kinematics based on the Joint Coordinate System (JCS), first proposed by Grood and ..
  6. pmc Strength in the periphery: growth cone biomechanics and substrate rigidity response in peripheral and central nervous system neurons
    Daniel Koch
    Department of Physics, Georgetown University, Washington, DC, USA
    Biophys J 102:452-60. 2012
    ....
  7. pmc Cell mechanics and the cytoskeleton
    Daniel A Fletcher
    Bioengineering and Biophysics, University of California, Berkeley, California 94720, USA
    Nature 463:485-92. 2010
    ..An important insight emerging from this work is that long-lived cytoskeletal structures may act as epigenetic determinants of cell shape, function and fate...
  8. ncbi Determining in vivo biomechanical properties of the cornea with an ocular response analyzer
    David A Luce
    Reichert Inc, Depew, New York, USA
    J Cataract Refract Surg 31:156-62. 2005
    ..To study the results of an ocular response analyzer (ORA) to determine the biomechanical properties of the cornea and their relationship to intraocular pressure (IOP)...
  9. ncbi Hip contact forces and gait patterns from routine activities
    G Bergmann
    Biomechanics Laboratory, Benjamin Frunklin School of Medicine, Free University of Berlin, Hindenburgdamm 30, 12203, Berlin, Germany
    J Biomech 34:859-71. 2001
    ..This is below the levels previously reported for two other patients (Bergmann et al., Clinical Biomechanics 26 (1993) 969-990)...
  10. pmc Force sensing by mechanical extension of the Src family kinase substrate p130Cas
    Yasuhiro Sawada
    Department of Biological Sciences, Columbia University, Sherman Fairchild Center Room 715, MC 2416, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Cell 127:1015-26. 2006
    ..Thus, we propose that Cas acts as a primary force sensor, transducing force into mechanical extension and thereby priming phosphorylation and activation of downstream signaling...
  11. pmc Learning to control a brain-machine interface for reaching and grasping by primates
    Jose M Carmena
    Department of Neurobiology, Duke University, Durham, North Carolina, USA
    PLoS Biol 1:E42. 2003
    ..Learning to operate the BMIc was paralleled by functional reorganization in multiple cortical areas, suggesting that the dynamic properties of the BMIc were incorporated into motor and sensory cortical representations...
  12. pmc Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching
    Andrey Revyakin
    Howard Hughes Medical Institute, Waksman Institute, and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 314:1139-43. 2006
    ....
  13. ncbi Local dynamic stability versus kinematic variability of continuous overground and treadmill walking
    J B Dingwell
    Sensory Motor Performance Program, Rehabiliation Institute of Chicago, IL 60611, USA
    J Biomech Eng 123:27-32. 2001
    ..Thus, motorized treadmills may produce misleading or erroneous results in situations where changes in neuromuscular control are likely to affect the variability and/or stability of locomotion...
  14. pmc Biomechanics and biophysics of cancer cells
    Subra Suresh
    Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 3:413-38. 2007
    ..This paper presents an overview of the rapidly expanding, nascent field of research that deals with the biomechanics and biophysics of cancer cells...
  15. ncbi The condition for dynamic stability
    A L Hof
    Institute of Human Movement Sciences, University of Groningen, University Hospital, PO Box 196, AD Groningen 9700, The Netherlands
    J Biomech 38:1-8. 2005
    ..Some experimental data of subjects standing on one or two feet, flatfoot and tiptoe, are presented to give an idea of the usual ranges of these margins of stability. Example data on walking are also presented...
  16. pmc Modular control of human walking: a simulation study
    Richard R Neptune
    Department of Mechanical Engineering, University of Texas at Austin, 1 University Station C2200, Austin, TX 78712, USA
    J Biomech 42:1282-7. 2009
    ..These results provide evidence that the identified modules can act as basic neural control elements that generate task-specific biomechanical functions to produce well-coordinated walking...
  17. pmc Decoding complete reach and grasp actions from local primary motor cortex populations
    Carlos E Vargas-Irwin
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 30:9659-69. 2010
    ....
  18. pmc A central source of movement variability
    Mark M Churchland
    Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Neuron 52:1085-96. 2006
    ..Thus, even for a highly practiced task, the ability to repeatedly plan the same movement limits our ability to repeatedly execute the same movement...
  19. pmc Evidence for a distributed hierarchy of action representation in the brain
    Scott T Grafton
    Department of Psychology, Room 3837, Building 251, University of California, Santa Barbara, CA 93106, United States
    Hum Mov Sci 26:590-616. 2007
    ....
  20. ncbi Symmetry and limb dominance in able-bodied gait: a review
    H Sadeghi
    Research Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Quebec, H3T 1C5, Montreal, Canada
    Gait Posture 12:34-45. 2000
    ..Further investigation is needed to demonstrate functional gait asymmetry and its relationship to laterality, taking into consideration the biomechanical aspects of gait...
  21. ncbi The central nervous system stabilizes unstable dynamics by learning optimal impedance
    E Burdet
    Department of Mechanical Engineering, National University of Singapore, 119260, Singapore
    Nature 414:446-9. 2001
    ..Our results show that humans learn to stabilize unstable dynamics using the skillful and energy-efficient strategy of selective control of impedance geometry...
  22. ncbi A framework for the in vivo pathomechanics of osteoarthritis at the knee
    Thomas P Andriacchi
    Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305 4038, USA
    Ann Biomed Eng 32:447-57. 2004
    ..The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee...
  23. ncbi Movement smoothness changes during stroke recovery
    Brandon Rohrer
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 22:8297-304. 2002
    ..This pattern was reproduced in a computer simulation of recovery based on submovement blending, suggesting that progressive blending of submovements underlies stroke recovery...
  24. pmc Cooperative effects of Rho and mechanical stretch on stress fiber organization
    Roland Kaunas
    Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:15895-900. 2005
    ..Our results demonstrate that the stretch-induced stress fiber orientation is a function of the interplay between Rho pathway activity and the magnitude of stretching...
  25. ncbi Mechanical properties and the hierarchical structure of bone
    J Y Rho
    Department of Biomedical Engineering, University of Memphis, TN 38152, USA
    Med Eng Phys 20:92-102. 1998
    ....
  26. ncbi The uncontrolled manifold concept: identifying control variables for a functional task
    J P Scholz
    Physical Therapy Department, McKinly Laboratory, University of Delaware, Newark 19716, USA
    Exp Brain Res 126:289-306. 1999
    ..The horizontal head position and the position of the hand were controlled less stably, while vertical head position appears to be no more controlled than joint motions...
  27. ncbi Coordination of locomotion with voluntary movements in humans
    Yuri P Ivanenko
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 00179 Rome, Italy
    J Neurosci 25:7238-53. 2005
    ....
  28. pmc Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
    T Miyazaki
    Department of Orthopaedic Surgery, Fukui Medical University, Japan
    Ann Rheum Dis 61:617-22. 2002
    ..To test the hypothesis that dynamic load at baseline can predict radiographic disease progression in patients with medial compartment knee osteoarthritis (OA)...
  29. ncbi Mechanics and modeling of plant cell growth
    Anja Geitmann
    Institut de recherche en biologie végétale, Departement de sciences biologiques, Universite de Montreal, Québec H1X2B2, Canada
    Trends Plant Sci 14:467-78. 2009
    ....
  30. ncbi Biomechanical consequences of scaling
    Andrew A Biewener
    Concord Field Station, Department of Organismic and Evolutionary Biology, Harvard University, Old Causeway Road, Bedford, MA 01730, USA
    J Exp Biol 208:1665-76. 2005
    ..Other 'low stress' tendons have larger safety factors, indicating that their primary design is for stiffness to reduce the amount of stretch that their muscles must overcome when contracting to control movement...
  31. pmc Biomechanics and wound healing in the cornea
    William J Dupps
    The Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, OH 44195, USA
    Exp Eye Res 83:709-20. 2006
    ....
  32. pmc Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications
    U Proske
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    J Physiol 537:333-45. 2001
    ..The ability of muscle to rapidly adapt following the damage from eccentric exercise raises the possibility of clinical applications of mild eccentric exercise, such as for protecting a muscle against more major injuries...
  33. ncbi Changes in the stiffness, strength, and toughness of human cortical bone with age
    P Zioupos
    Department of Biology, University of York, York, UK
    Bone 22:57-66. 1998
    ..The macrocrack was preceded by less damage, and once created needed less energy to drive through the tissue (Wf)...
  34. ncbi Persistence of motor adaptation during constrained, multi-joint, arm movements
    R A Scheidt
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60622, USA
    J Neurophysiol 84:853-62. 2000
    ....
  35. ncbi Effect of superficial collagen patterns and fibrillation of femoral articular cartilage on knee joint mechanics-a 3D finite element analysis
    M E Mononen
    Department of Applied Physics, University of Eastern Finland, POB 1627, FI 70211 Kuopio, Finland
    J Biomech 45:579-87. 2012
    ..This study provides further evidence on the importance of the collagen fibril organization for the optimal function of articular cartilage...
  36. ncbi A human knee joint model considering fluid pressure and fiber orientation in cartilages and menisci
    K B Gu
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    Med Eng Phys 33:497-503. 2011
    ..The present study indicates the necessity of implementing the fluid pressure and anisotropic fibril reinforcement in articular cartilage for a more accurate understanding of the mechanics of the knee...
  37. ncbi Acceleration patterns of the head and pelvis when walking are associated with risk of falling in community-dwelling older people
    Hylton B Menz
    Prince of Wales Medical Research Institute, University of New South Wales, High Street, Randwick, NSW 2031, Australia
    J Gerontol A Biol Sci Med Sci 58:M446-52. 2003
    ....
  38. ncbi Agonist-antagonist active knee prosthesis: a preliminary study in level-ground walking
    Ernesto C Martinez-Villalpando
    Massachusetts Institute of Technology Media Laboratory, Cambridge, MA, USA
    J Rehabil Res Dev 46:361-73. 2009
    ....
  39. ncbi Efficient bipedal robots based on passive-dynamic walkers
    Steve Collins
    Mechanical Engineering, University of Michigan, Ann Arbor, MI 48104, USA
    Science 307:1082-5. 2005
    ..These robots use less control and less energy than other powered robots, yet walk more naturally, further suggesting the importance of passive-dynamics in human locomotion...
  40. doi Nanomechanical analysis of cells from cancer patients
    Sarah E Cross
    Nat Nanotechnol 2:780-3. 2007
    ..These results show that nanomechanical analysis correlates well with immunohistochemical testing currently used for detecting cancer...
  41. pmc Stresses at the cell-to-substrate interface during locomotion of fibroblasts
    M Dembo
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 2407, USA
    Biophys J 76:2307-16. 1999
    ..These observations demonstrate that the lamellipodium of the fibroblast is able to generate intense traction stress. The cell body and posterior seem to be mechanically passive structures pulled forward entirely by this action...
  42. pmc Correlation between single limb support phase and self-evaluation questionnaires in knee osteoarthritis populations
    Ronen Debi
    Department of Orthopedic Surgery, Assaf Harofeh Medical Center, Zerifin, Israel
    Disabil Rehabil 33:1103-9. 2011
    ....
  43. ncbi Interlimb coordination during locomotion: what can be adapted and stored?
    Darcy S Reisman
    Department of Physical Therapy, University of Delaware, Newark, USA
    J Neurophysiol 94:2403-15. 2005
    ..The differences in intra- versus interlimb control may be related to the varying complexity of the parameters, task demands, and/or the level of neural control necessary for their adaptation...
  44. ncbi Mechanism of force generation by myosin heads in skeletal muscle
    Gabriella Piazzesi
    Universita di Firenze, Viale G B Morgagni 63, I 50134 Firenze, Italy
    Nature 415:659-62. 2002
    ....
  45. pmc Dynamic principles of gait and their clinical implications
    Arthur D Kuo
    Departments of Mechanical Engineering and Biomedical Engineering, University of Michigan, 2350 Hayward St, Ann Arbor, MI 48109 2125, USA
    Phys Ther 90:157-74. 2010
    ..An understanding of the role of biomechanics in the generation of healthy gait, therefore, can provide insight into these deficits...
  46. ncbi Effects of charité artificial disc on the implanted and adjacent spinal segments mechanics using a hybrid testing protocol
    Vijay K Goel
    Spine Research Center, University of Toledo and Medical University of Ohio, Toledo, OH 43606, USA
    Spine (Phila Pa 1976) 30:2755-64. 2005
    ..Finite element model of L3-S1 segment and confirmatory cadaveric testing were used to investigate the biomechanical effects of a mobile core type artificial disc (Charité artificial disc; DePuy Spine, Raynham, MA) on the lumbar spine...
  47. pmc Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch
    Cheng Chen
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China
    PLoS ONE 5:e12035. 2010
    ..We have shown recently that in response to a transient stretch the adherent eukaryotic cell promptly fluidizes and then gradually resolidifies, but mechanism is not yet understood...
  48. ncbi Control of foot trajectory in human locomotion: role of ground contact forces in simulated reduced gravity
    Y P Ivanenko
    Sezione di Fisiologia Umana, Istituto Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    J Neurophysiol 87:3070-89. 2002
    ..The results did not depend on the specific instruction given to the subject. Therefore we conclude that minimal contact forces are sufficient for accurate foot trajectory control...
  49. pmc Chemically mediated mechanical expansion of the pollen tube cell wall
    Enrique R Rojas
    Department of Physics, Harvard University, Cambridge, Massachusetts, USA
    Biophys J 101:1844-53. 2011
    ..In short, the model captures the rich phenomenology of pollen tube morphogenesis and has implications for other plant cell types...
  50. pmc The influence of gait speed on local dynamic stability of walking
    Scott A England
    Musculoskeletal Biomechanics Laboratories, Department of Engineering Science and Mechanics, School of Biomedical Engineering and Science, Virginia Polytechnic Institute and State University, 219 Norris Hall 0219, Blacksburg, VA 24061, United States
    Gait Posture 25:172-8. 2007
    ..This suggests that slower walking velocities lead to increases in stability. These results may reveal more detailed information on the behavior of the neuro-controller than variability-based analyses alone...
  51. ncbi Toward a new theory of motor synergies
    Mark L Latash
    Dept of Kinesiology, Pennyslvania State University, University Park, PA 16802, USA
    Motor Control 11:276-308. 2007
    ..We show how this concept establishes links between the various accounts for how movement is organized in redundant effector systems...
  52. ncbi Gait differences between individuals with post-stroke hemiparesis and non-disabled controls at matched speeds
    George Chen
    Rehabilitation R and D Center 153, VA Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA 94304 1200, USA
    Gait Posture 22:51-6. 2005
    ..The differences provide insights, concerning hemiparetic impairment and related compensatory strategies, that are in addition to the observation of slow walking speed...
  53. ncbi Postural stability in the elderly: a comparison between fallers and non-fallers
    I Melzer
    Department of Clinical Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev and Key Institute of Education, PO Box 653, Beer Sheva, Israel
    Age Ageing 33:602-7. 2004
    ..the identification of specific risk factors for falls in community-dwelling elderly persons is required to identify older people at risk of falling...
  54. ncbi Diversity and variation in biomechanical exposure: what is it, and why would we like to know?
    Svend Erik Mathiassen
    Centre for Musculoskeletal Research, University of Gavle, P O Box 7629, SE 90712 Umeå, Sweden
    Appl Ergon 37:419-27. 2006
    ..Operational methods for assessing these concepts are also discussed...
  55. pmc Testing criteria for spinal implants: recommendations for the standardization of in vitro stability testing of spinal implants
    H J Wilke
    Department of Orthopaedic Research and Biomechanics, University of Ulm, Germany
    Eur Spine J 7:148-54. 1998
    ..This paper describes the recommended loading methods, specimen conditions, and analysis parameters resulting from these workshops...
  56. ncbi Age-related differences in walking stability
    Hylton B Menz
    Prince of Wales Medical Research Institute, High Street, Randwick, New South Wales 2031, Australia
    Age Ageing 32:137-42. 2003
    ..a large proportion of falls in older people occur when walking; however the mechanisms underlying impaired balance during gait are poorly understood...
  57. pmc Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head
    Claude F Burgoyne
    Optic Nerve Head Research Laboratories, Devers Eye Institute, Portland, OR 97232, USA
    J Glaucoma 17:318-28. 2008
    We propose that age-related alterations in optic nerve head (ONH) biomechanics underlie the clinical behavior and increased susceptibility of the aged ONH to glaucomatous damage...
  58. ncbi Assessment of spatio-temporal gait parameters from trunk accelerations during human walking
    Wiebren Zijlstra
    Institute of Human Movement Sciences, University of Groningen, PO Box 196, 9700 AD Groningen, The Netherlands
    Gait Posture 18:1-10. 2003
    ..The possibility to identify subsequent stride cycles can be the basis for an analysis of other signals (e.g. kinematic or muscle activity) within the stride cycle...
  59. ncbi Lower limb biomechanics during gait do not return to normal following total hip arthroplasty
    Mélanie L Beaulieu
    School of Human Kinetics, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Gait Posture 32:269-73. 2010
    ..Further investigation is needed to confirm the reasons why THA patients' gait mechanics do not return to normal following surgery to develop better surgical techniques and/or rehabilitation programs...
  60. ncbi Sickle cell biomechanics
    Gilda A Barabino
    The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
    Annu Rev Biomed Eng 12:345-67. 2010
    ..This review discusses the characterization of the biomechanical properties of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology of the disease...
  61. ncbi Toward integration of geometric morphometrics and computational biomechanics: new methods for 3D virtual reconstruction and quantitative analysis of Finite Element Models
    W C H Parr
    School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Theor Biol 301:1-14. 2012
    ..predicted or hypothetical morphologies has a range of potential applications in functional morphology and biomechanics. One of the most challenging of these applications is Finite Element Analysis (FEA), a potentially powerful non-..
  62. ncbi Quantifying generalization from trial-by-trial behavior of adaptive systems that learn with basis functions: theory and experiments in human motor control
    Opher Donchin
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Neurosci 23:9032-45. 2003
    ....
  63. ncbi An overview on plant cuticle biomechanics
    Eva Domínguez
    Estacion Experimental La Mayora, CSIC, E 29750 Algarrobo Costa, Malaga, Spain
    Plant Sci 181:77-84. 2011
    Plant biomechanics combines the principles of physics, chemistry and engineering to answer questions about plant growth, development and interaction with the environment...
  64. ncbi Ambulatory estimation of foot placement during walking using inertial sensors
    H Martin Schepers
    Institute for Biomedical Technology and Technical Medicine MIRA, University of Twente, AE Enschede, The Netherlands
    J Biomech 43:3138-43. 2010
    ..It is concluded that the ambulatory measurement system was able to reliably estimate foot placement during walking...
  65. ncbi Assessment of the epithelium's contribution to corneal biomechanics
    Ahmed Elsheikh
    Division of Civil Engineering, University of Dundee, Dundee, UK
    Exp Eye Res 86:445-51. 2008
    Determining the epithelium's contribution to corneal biomechanics is important for the predictive numerical simulation of corneal biomechanical behaviour in which the cornea's five main layers are represented separately...
  66. pmc Force transmission in migrating cells
    Maxime F Fournier
    Laboratoire de Biophysique Cellulaire, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Cell Biol 188:287-97. 2010
    ....
  67. ncbi Cranial biomechanics of Diplodocus (Dinosauria, Sauropoda): testing hypotheses of feeding behaviour in an extinct megaherbivore
    Mark T Young
    School of Earth Sciences, University of Bristol, Bristol, BS8 1RJ, UK
    Naturwissenschaften 99:637-43. 2012
    Sauropod dinosaurs were the largest terrestrial herbivores and pushed at the limits of vertebrate biomechanics and physiology...
  68. ncbi Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 1:15-30. 2005
    ..Some general perspectives on connections among structure, single-cell mechanical properties and biological responses associated with pathogenic processes are also provided in the context of the two diseases considered in this work...
  69. pmc Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness
    Ramaswamy Krishnan
    Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5486. 2009
    ..Cytoskeletal softness and fragility, we argue, is consistent with early evolutionary adaptations of the eukaryotic cell to material properties of a soft inert microenvironment...
  70. ncbi Cell mechanics: integrating cell responses to mechanical stimuli
    Paul A Janmey
    Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Biomed Eng 9:1-34. 2007
    ....
  71. pmc The mechanisms of the residual force enhancement after stretch of skeletal muscle: non-uniformity in half-sarcomeres and stiffness of titin
    Dilson E Rassier
    Departments of Kinesiology and Physical Education, Physics and Physiology, McGill University, Montreal PQ, Canada
    Proc Biol Sci 279:2705-13. 2012
    ..These mechanisms are compatible with most observations in the literature, and can be tested directly with emerging technologies in the near future...
  72. ncbi How animals move: an integrative view
    M H Dickinson
    Department of Integrative Biology, University of California, Berkeley, CA 94720, USA
    Science 288:100-6. 2000
    ..Integrative approaches reveal not only how each component within a locomotor system operates but how they function as a collective whole...
  73. ncbi Modular control of limb movements during human locomotion
    Yuri P Ivanenko
    Department of Neuromotor Physiology, Santa Lucia Foundation, 00179 Rome, Italy
    J Neurosci 27:11149-61. 2007
    ..The hypothesis finds support in the animal findings that limb proprioception may also be encoded in terms of these global limb parameters...
  74. ncbi The human ankle during walking: implications for design of biomimetic ankle prostheses
    Andrew H Hansen
    Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Biomech 37:1467-74. 2004
    ..This notion is supported by the sign of the ankle power at the time of opposite heel contact, which was negative for slow speeds, was near zero at normal speeds, and was positive for fast walking speeds...
  75. ncbi Tuning of a basic coordination pattern constructs straight-ahead and curved walking in humans
    Gregoire Courtine
    Sezione di Fisiologia Umana, Dipartimento di Medicina Sperimentale, Universita di Pavia, and Centro Studi Attività Motorie, Fondazione Salvatore Maugeri Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Scientifico di Pavia, Pavia, Italy
    J Neurophysiol 91:1524-35. 2004
    ..During locomotion, the descending command tunes basic spinal networks so as to produce the changes in amplitude and phase relationships of the spinal output, sufficient to achieve the body turn...
  76. ncbi Cross-talk between language processes and overt motor behavior in the first 200 msec of processing
    Véronique Boulenger
    CNRS UMR, 5015 Institut des Sciences Cognitives, Bron Cedex, France
    J Cogn Neurosci 18:1607-15. 2006
    ....
  77. ncbi A wake-based correlate of swimming performance and foraging behavior in seven co-occurring jellyfish species
    J O Dabiri
    Graduate Aeronautical Laboratories and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Biol 213:1217-25. 2010
    ..This enables a quantitative, physically based understanding of how alterations in the fluid dynamics of aquatic and aerial animals throughout their evolution can result in distinct ecological functions...
  78. ncbi Energetics and biomechanics as determining factors of swimming performance: updating the state of the art
    Tiago M Barbosa
    Polytechnic Institute of Braganca, Portugal
    J Sci Med Sport 13:262-9. 2010
    ..of this paper was to do an update of the "state of art" about the interplay between performance, energetic and biomechanics in competitive swimming...
  79. ncbi Gender-specific effect of obesity on balance
    Francesco Menegoni
    Bioengineering Department, Politecnico di Milano, Milano, Italy
    Obesity (Silver Spring) 17:1951-6. 2009
    Obesity modifies the body geometry by adding mass to different regions and it influences the biomechanics of activities of daily living...
  80. pmc Muscle contributions to propulsion and support during running
    Samuel R Hamner
    Department of Mechanical Engineering, Stanford University, Stanford, CA 94305 5450, USA
    J Biomech 43:2709-16. 2010
    ..Our analysis reveals that the quadriceps and plantarflexors are the major contributors to acceleration of the body mass center during running...
  81. pmc How objects are grasped: the interplay between affordances and end-goals
    Luisa Sartori
    Dipartimento di Psicologia Generale, Universita di Padova, Padova, Italy
    PLoS ONE 6:e25203. 2011
    ..Little is known about how the placement of individual fingers on objects is affected by the end-goal of the action...
  82. ncbi Kinematics of flight and the relationship to the vortex wake of a Pallas' long tongued bat (Glossophaga soricina)
    Marta Wolf
    Department of Biology, Lund University, Solvegatan 37, SE 223 62 Lund, Sweden
    J Exp Biol 213:2142-53. 2010
    ..This study of the kinematics strongly indicates that the flight of bats is governed by an unsteady high-lift mechanism at low flight speeds and points to differences between birds and bats...
  83. pmc Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity
    P G Cox
    Department of Musculoskeletal Biology, University of Liverpool, Liverpool, UK
    J Anat 219:696-709. 2011
    ....
  84. ncbi Running springs: speed and animal size
    C T Farley
    Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138
    J Exp Biol 185:71-86. 1993
    ..The length of time that the feet are in contact with the ground increases with body mass in nearly the same way as the resonant period of vertical vibration...
  85. ncbi Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids
    Jan Lipfert
    Department of BioNanoScience, Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
    Nat Commun 2:439. 2011
    ..We utilize FOMT to measure the force-dependent torsional stiffness of DNA from equilibrium rotational fluctuations and to follow the assembly of recombination protein A filaments on DNA...
  86. pmc Kinematic variability, fractal dynamics and local dynamic stability of treadmill walking
    Philippe Terrier
    IRR, Institut de Recherche en Réadaptation, Sion, Switzerland
    J Neuroeng Rehabil 8:12. 2011
    ..Classical (Standard Deviation, SD) and non-linear (fractal dynamics, local dynamic stability) methods were used. In addition, the correlations between the different variability indexes were analyzed...
  87. ncbi Comparison of motor control deficits during treadmill and overground walking poststroke
    Steven A Kautz
    Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurorehabil Neural Repair 25:756-65. 2011
    ..treadmills (TMs) provide an alternative to the conventional overground (OG) setting and allow new avenues for analyzing the biomechanics and motor control of walking. However, walking control may differ on a TM compared with walking OG.
  88. pmc Biomechanics of abdominal aortic aneurysm
    David A Vorp
    Department of Surgery, Division of Vascular Surgery, Department of Bioengineering, McGowan Institute for Regenerative Medicine, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, USA
    J Biomech 40:1887-902. 2007
    ..The biomechanics of AAA has been studied with great interest since aneurysm rupture is a mechanical failure of the degenerated ..
  89. ncbi Creep behavior of the intact and meniscectomy knee joints
    M Kazemi
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    J Mech Behav Biomed Mater 4:1351-8. 2011
    ..For the femoral cartilage, the maximum principal stress was generally in agreement with the fiber direction, which indicated the essential role of fibers in load support of the tissue...
  90. ncbi Biomechanical factors associated with tibial stress fracture in female runners
    Clare E Milner
    Department of Physical Therapy, University of Delaware, Newark, DE 19716, USA
    Med Sci Sports Exerc 38:323-8. 2006
    ..This cross-sectional study was conducted to determine whether differences in structure and running mechanics exist between trained distance runners with a history of prior TSF and those who have never sustained a fracture...
  91. ncbi Ten years of tension: single-molecule DNA mechanics
    Carlos Bustamante
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 421:423-7. 2003
    ..These studies have illuminated the nature of interactions between DNA and proteins, the constraints within which the cellular machinery operates, and the forces created by DNA-dependent motors...
  92. pmc Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?
    Amnon Buxboim
    Biophysical Engineering Lab, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 123:297-308. 2010
    ..Ultimately, cells feel the difference between stiff or soft and thick or thin surroundings, regardless of whether or not they are of royal descent...
  93. ncbi Postural feedback responses scale with biomechanical constraints in human standing
    Sukyung Park
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
    Exp Brain Res 154:417-27. 2004
    ..These results indicate that postural adjustments can be described as a single feedback control scheme, with scalable heterogenic gains that are adjusted according to biomechanical constraints...
  94. pmc Kinematic measures for assessing gait stability in elderly individuals: a systematic review
    D Hamacher
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Center for Sports Science and Sports Medicine Berlin, Germany
    J R Soc Interface 8:1682-98. 2011
    ..Incorporation of the most promising measures in combined retrospective and prospective studies for understanding fall risk and designing preventive strategies is warranted...
  95. ncbi Kinematic variability and local dynamic stability of upper body motions when walking at different speeds
    Jonathan B Dingwell
    Department of Kinesiology and Health Education, University of Texas at Austin, 1 University Station, D3700, Austin, TX 78712 0360, USA
    J Biomech 39:444-52. 2006
    ..These results support the clinically based intuition that people who are at increased risk of falling walk slower to improve their stability, even at the cost of increased variability...
  96. ncbi Quaternion-based extended Kalman filter for determining orientation by inertial and magnetic sensing
    Angelo M Sabatini
    ARTS Lab, Scuola Superiore Sant Anna, Piazza Martiri della Libertà, Pisa 56127, Italy
    IEEE Trans Biomed Eng 53:1346-56. 2006
    ....
  97. ncbi Mechanics of the kinesin step
    N J Carter
    Molecular Motors Group, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK
    Nature 435:308-12. 2005
    ..The data suggest an underlying mechanism in which, once ATP has bound to the microtubule-attached head, the other head undergoes a diffusional search for its next site, the outcome of which can be biased by an applied load...
  98. pmc Hydrodynamic stretching of single cells for large population mechanical phenotyping
    Daniel R Gossett
    Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:7630-5. 2012
    ....
  99. pmc Magnitude and pattern of 3D kinematic and kinetic gait profiles in persons with stroke: relationship to walking speed
    C Maria Kim
    Rehabilitation Research Laboratory, GF Strong Rehab Centre, 4255 Laurel Street, Vancouver, BC, V5Z ZG9, Canada
    Gait Posture 20:140-6. 2004
    ..Furthermore, profiles which resemble gait patterns of neurologically healthy adults do not necessarily result in the faster gait speeds for individuals with chronic stroke...
  100. pmc Insights into the ecology and evolutionary success of crocodilians revealed through bite-force and tooth-pressure experimentation
    Gregory M Erickson
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 7:e31781. 2012
    ..How these factors relate to biomechanical performance during feeding and their relevance to crocodilian evolutionary success are not known...
  101. ncbi Evidence for the flexible sensorimotor strategies predicted by optimal feedback control
    Dan Liu
    Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093 0515, USA
    J Neurosci 27:9354-68. 2007
    ..The results suggest that the remarkable flexibility of motor behavior arises from sensorimotor control laws optimized for composite cost functions...

Research Grants78

  1. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2004
    ..This BRP brings together the capabilities of an experienced computational biomechanics research group, four senior orthopaedic hip surgeons, a veterinary research orthopaedist, and an industry-based ..
  2. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013
    ..time points and determine the effect of serum measures of mineral homeostasis, bone turnover, architecture and biomechanics, and arterial calcification, aorta compliance and left ventricular mass index...
  3. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ....
  4. Aligned Tendon or Ligament Derived Matrix Nanoscaffolds for Rotator Cuff Repair
    Dianne Little; Fiscal Year: 2013
    ..Her immediate career development goals in the current proposal will be in biomechanics and tissue engineering and will allow expansion of current skills in mechanical testing and stress-strain ..
  5. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    ..motion are supplied by the prosthetic ankle joint, people with a lower limb amputation will achieve equivalent biomechanics, muscle activity, and metabolic energy costs compared to non-amputees...
  6. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2013
    ..applicants'career goal is to develop as an independent musculoskeletal investigator with expertise in bone biomechanics and imaging to achieve the ultimate public health aim of helping to reduce fragility fracture risk associated ..
  7. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2011
    ..applicants'career goal is to develop as an independent musculoskeletal investigator with expertise in bone biomechanics and imaging to achieve the ultimate public health aim of helping to reduce fragility fracture risk associated ..
  8. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..D., and Michael Recht, M.D., who are world- renowned for their contributions to osteoarthritis biology, biomechanics, biomarker, and imaging research. Additional key consultants James Babb, Ph.D., Christian Glaser, M.D...
  9. Connective tissue and nervous system mechanisms of CAM therapies for low back pai
    Helene M Langevin; Fiscal Year: 2013
    ..improvement in clinical trials using ultrasound-based non-invasive measures of connective tissue structure and biomechanics. Our long term goal is to use this improved mechanistic understanding as a basis for the development of ..
  10. Characterizing Patellofemoral Joint Stress Using Patient-Specific Models
    GARY BEAUPRE; Fiscal Year: 2012
    ..pain, one clinician noted that treatment is often based on "traditional beliefs regarding patellofemoral biomechanics" and "all too often, the clinical results from this type of approach are less than desirable"...
  11. Robust BCT for Clinical Use
    DAVID KOPPERDAHL; Fiscal Year: 2010
    ..Specifically, we propose in this Phase-I project to combine expertise in computer vision, CT scanning, and biomechanics in order to develop an automated method of "phantomless" cross-calibration of CT scans for robust vertebral ..
  12. Obesity, Biomechanics, and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2013
    ..The results of this study will provide new insight into key elements of the pathogenesis of OA, and ultimately could lead to new treatments that exploit physical, dietary, and molecular therapies to prevent disease. ..
  13. The Biomechanics of the Human Posterior Sclera: Effects of Age, Sex, and Glaucoma
    Thao D Nguyen; Fiscal Year: 2013
    ....
  14. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
    ..Quantitative assessment of muscle viscosity may shed light to many problems of medical biomechanics and sports medicine...
  15. Connective Tissue Mechanotransduction
    Helene M Langevin; Fiscal Year: 2012
    ..treatments including manual and movement-based therapies are concerned with optimizing body alignment, posture, biomechanics and quality of movement...
  16. CRCNS: Computation-Enabled Adaptive Ventilatory Control System
    Ranu Jung; Fiscal Year: 2013
    ..The training component will build transdisciplinary expertise in neuroscience, biomechanics, rehabilitation, neuromorphic engineering and neural control systems and will provide trainees with the skills ..
  17. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..measurements of meniscal T2* values with direct measurements of meniscal structure (histology) and function (biomechanics) at each discrete time point...
  18. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
    Marie Demay; Fiscal Year: 2013
    ....
  19. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..The biomechanics of locomotion are better defined in cats and cats have a hindlimb gait that is close to human than is the rat...
  20. Computational Modeling and Accelerated Aging of the Ascending Aorta
    Jay D Humphrey; Fiscal Year: 2013
    ..a next generation computational (finite element) mixture model of the ascending aorta that embodies the unique biomechanics: multiaxial loading, regionally varying residual stresses and nonlinear material properties that off-set ..
  21. SINGLE SUTURE CRANIOSYNOSTOSIS: CANDIDATE GENE AND PATHWAY DISCOVERY
    Michael L Cunningham; Fiscal Year: 2013
    ..We will utilize measures of osteoblast growth and differentiation as well as measures of cellular biomechanics to refine the biologic phenotype of our original cohort...
  22. The biomechanics of morphogenesis in the frog
    Lance A Davidson; Fiscal Year: 2013
    ....
  23. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
    ..The objective of this research proposal is to provide clinicians with a biomechanics-based tool to aide in the diagnosis of inflicted or non-inflicted trauma with a history of a low- height fall...
  24. FGF SIGNALING IN SKELETAL DEVELOPMENT, HOMEOSTASIS AND AGING
    David M Ornitz; Fiscal Year: 2013
    ..Our multidisciplinary team brings together expertise in developmental and bone biology, bone structure and biomechanics, and genomics and bioinformatics that, combined with the genetic tools at our disposal, puts us in a unique ..
  25. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2012
    ..Our research is being carried out to better understand how patients and bacteria interact and to look for new strategies for protecting and treating patients with serious bloodstream infections. ..
  26. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    ..Novel imaging, biomechanics and biomarker assessments will be compared to histology, immunohistochemistry and biochemical analyses...
  27. EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATION
    Jay D Humphrey; Fiscal Year: 2010
    ..75% of abdominal aortic aneurysms involve an intraluminal thrombus, which is thought to adversely affect the biomechanics of the aneurysmal wall as well as biochemical processes related to chronic inflammation and oxygen transport to ..
  28. Fibrotic effects and regulation of MMP proteins in thrombus resolution
    Rajabrata Sarkar; Fiscal Year: 2009
    ..vein wall fibrosis and loss of vein wall compliance and elasticity using novel assays of mouse vein biomechanics.Tissue-specific transgenic overexpression of MMP-2, -14 and -9 as well as adenoviral vectors encoding these ..
  29. Cellular Biomechanics of Heat-Shock Induced Defects in Drosophila Embryogenesis
    M Shane Hutson; Fiscal Year: 2013
    ..by which committed cells drive morphogenesis through spatiotemporal regulation of cell- and tissue-level biomechanics. This project will focus on one example of this effect - heat shocks during the gastrulation stage of ..
  30. Musculoskeletal Biomechanics of Gradient Walking in Obese Adults
    RAYMOND CLIFTON BROWNING; Fiscal Year: 2012
    ..The existing walking biomechanics data base does not apply to the 60+% of American adults who are overweight or obese nor to uphill or downhill ..
  31. Real-time microviscosity measurement tools for the cell
    Mark A Haidekker; Fiscal Year: 2010
    ..in cell signaling under fluid shear stress (vascular endothelial cells) - Analysis of changes in cell membrane biomechanics in atherosclerosis - Studies involving membrane lipid rafts - Analysis of the role of cytoplasmic viscosity in ..
  32. Directing Stem Cell Differentiation on Biologically Inspired Micropatterned Surfa
    Anita Shukla; Fiscal Year: 2012
    ..The role of biomechanics in influencing hMSC differentiation has recently been investigated...
  33. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2012
    ..In Aim 2, we will evaluate femoral geometry (uCT) and biomechanics (torsional loading to failure) of 6 week and 4 month old oim and G610C mice in relation to mineral and matrix, ..
  34. Development of a Low Cost, Real-time Biofeedback Gait Retraining System
    SAUNDERS WHITTLESEY; Fiscal Year: 2012
    ..established set of protocols and a new software system that C-Motion can develop based on our high end Visual3D biomechanics research tools...
  35. Gender Specific Evolution of Abdominal Aortic Aneurysm Composition and Properties
    Jay D Humphrey; Fiscal Year: 2013
    ..Fortunately, advances in medical imaging and computational biomechanics provide a special opportunity to estimate, on a patient-specific basis, both the hemodynamic loads experienced ..
  36. Clinical Validation of BCT - Phase II
    DAVID KOPPERDAHL; Fiscal Year: 2010
    ..A 3D biomechanics-based technique, which we term Biomechanical Computed Tomography (BCT), addresses this need through a ..
  37. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    CHRISTINA ROSE MARMAROU; Fiscal Year: 2012
    ..This proposal will address the fundamental mechanism of brain swelling and how it can be blocked pharmacologically. ..
  38. A Middle Ear Twist: Imaging, Physiology & Biomechanics
    RYAN PATRICK JACKSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In this project, we will investigate the biomechanics that enable high-frequency (JHF) sound, greater than 10 kHz, to be transduced from middle-ear to cochlea in a group of terrestrial mammals...
  39. Biomechanics and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2012
    ..The information gained from this Program Project will provide new insights into the development new pharmacologic, psychological, and physical therapies for the treatment of OA. ..
  40. Joint Capsule Biomechanics and Transport in Rat Models of Aging and Disease
    WILLIAM JOSEPH MCCARTY; Fiscal Year: 2012
    ..These results may also be useful in identifying potential clinical intervention points and strategies to reverse pathological joint changes due to aging and OA. ..
  41. ROS Mechanisms in BAV Aortopathy
    THOMAS GILLETTE GLEASON; Fiscal Year: 2013
    ..The team's pioneering techniques for studying blood vessel biomechanics will be utilized throughout the research design...
  42. Extracelluar Matrix Organization and Biomechanics of the Lamina Cribrosa and Peri
    JONATHAN PIETER VANDE GEEST; Fiscal Year: 2013
    ..abstract_text> ..
  43. Muscle Weakness and Post-Traumatic Knee OA
    Terese L Chmielewski; Fiscal Year: 2011
    ..She has a Master's degree in Physical Therapy and a Ph.D. in Biomechanics and Movement Sciences...
  44. Study of bone disease in Thalassemia
    Maria G Vogiatzi; Fiscal Year: 2010
    ..The proposal describes a 5 year training program for Dr Vogiatzi in the areas of biomechanics, biomineralization, analytical microscopy and bone biology using a mouse model of thalassemia to prepare her ..
  45. Structural origin of fibrin clot mechanical properties
    John W Weisel; Fiscal Year: 2012
    ..The proposal represents a new and promising field of biomedical research, namely biomechanics of hemostasis and thrombosis...
  46. Botulinum toxin in muscles of mastication
    Susan W Herring; Fiscal Year: 2012
    ..It will provide new information on how the muscles and their nerves are affected, how jaw biomechanics are altered, and the extent of neuroplasticity of the jaw motor system...
  47. Biomechanics of Leukocytes and Molecular Imaging Agents
    MICHAEL BRANDEAU LAWRENCE; Fiscal Year: 2010
    ..An integrative systems approach is used to translate concepts from basic science rooted in the biomechanics of leukocyte adhesion to applications of molecular imaging using targeted ultrasound contrast agents...
  48. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    MOSTAFA GABER; Fiscal Year: 2009
    ..The model will be used to characterize the effect of total body irradiation on wound healing, wound biomechanics, microvascular damage and repair, blood chemistry, and serum cytokine expression. 2...
  49. Training and research application for c-spine ultrasound of an aging population.
    DANIEL BUCKLAND; Fiscal Year: 2013
    ..appropriate protective equipment and activities for older individuals, but more information is needed about the biomechanics of these activities to properly engineer solutions...
  50. Genetics of Foot Disorders
    Joanne M Jordan; Fiscal Year: 2012
    ..We now have the unique opportunity to link data on specific foot disorders and foot biomechanics to a wealth of genetic data in the FHS and the Johnston County OA Project (JoCo OA), two community-based ..
  51. Mechanics of Hearing Workshop
    KIRIAKI DOMENICA KARAVITAKI; Fiscal Year: 2013
    ..have provided the primary forum for presenting, debating, and sparking advances in the fields of auditory biomechanics and biophysics...
  52. Foot Disorders, Pain and Physical Disability in Elders
    Marian T Hannan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Little population-based data exist on foot biomechanics and foot disorders, and foot pathologies are often overlooked as important potential causes of physical limitations, impaired balance, and lower ..
  53. A Probabilistic Pose Estimation Algorithm for 3D Motion Capture Data
    W Scott Selbie; Fiscal Year: 2011
    ..Visual3D, the most advanced clinical biomechanics analysis software available commercially for 3D motion capture data, contains solutions for the estimation of ..
  54. Multiscale, Multiphysics Model of Thrombus Biomechanics in Aortic Dissection
    George Karniadakis; Fiscal Year: 2013
    ..We will develop the first data-driven, multiscale, multiphysics model of the biomechanics of intramural throm- bus in aortic dissection...
  55. Peripheral Mechanisms Governing Tactile Encoding During Normal Target Remodeling
    Ellen A Lumpkin; Fiscal Year: 2013
    ..combining experimental techniques, including neurophysiology, 3D microscopy, quantitative morphometry, tissue biomechanics and novel mouse models, with computational tools such as novel network models of neuronal dynamics, ..
  56. Age-related Changes in Thoracic Spine Biomechanics
    Dennis Anderson; Fiscal Year: 2013
    ..The broad lack of information on thoracic biomechanics has previously stymied the development and validation of such a model, which will be of great importance in ..
  57. Foot Prosthesis Using Tensegrity Design Principles
    JEROME RIFKIN; Fiscal Year: 2010
    ..lower-limb amputees, who will be able to return to activities they once enjoyed because of the greatly improved biomechanics of the foot...
  58. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    Duane D Miller; Fiscal Year: 2012
    ..The model will be used to characterize the effect of total body irradiation on wound healing, wound biomechanics, microvascular damage and repair, blood chemistry, and serum cytokine expression. 2...
  59. Design and Assessment of a Compliant Nanofibrous Vascular Graft
    Kelvin G M Brockbank; Fiscal Year: 2011
    ..These aims include biomechanics and graft seeding with cells and in vitro assessment of remodeling profiles and retention of mechanical ..
  60. The In Vivo Biomechanics of Lateral Ankle Ligament Injury and Reconstruction
    Louis E DeFrate; Fiscal Year: 2010
    ..These data will help to identify mechanisms leading to joint degeneration after these injuries and may lead to better reconstruction techniques. ..
  61. Biomechanical Regulation of Oxidative Homeostasis in Articular Cartilage
    RITA ISSAM ISSA; Fiscal Year: 2011
    ..I will receive support from a critical mass of investigators with expertise in musculoskeletal biomechanics, oxidative response pathways, and proteomic and genetic analysis...
  62. Acoustic Behavior - Neural and Comparative Bases
    Ronald R Hoy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long-term goal of this laboratory is to understand how biomechanics, anatomy, and physiology enable hearing of high sensitivity and directional acuity...
  63. Real-time monitoring of knee forces and kinematics in vivo
    DARRYL DAVID D apos LIMA; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The data collected will be of enormous benefit to the field of knee biomechanics in general and knee arthroplasty in particular...
  64. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    ..the human tongue that allows it to perform the movements that are unique to human speech and swallowing? The biomechanics of the tongue are dependent on its anatomy, and some of the most basic facts of human tongue anatomy are ..
  65. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2001
    ..the human tongue that allows it to perform the movements that are unique to human speech and swallowing? The biomechanics of the tongue are dependent on its anatomy, and some of the most basic facts of human tongue anatomy are ..
  66. AGE, SENSATION AND FALLS--BIOMECHANICS AND PREVENTION
    Ge Wu; Fiscal Year: 1999
    The primary goals of this proposal are to study the biomechanics of posture at the level of single body segments in relation to age and peripheral sensory deficits in the visual and somatosensory systems that the aging process; also to ..
  67. An injectable biocompatible hydrogel nucleus pulposus replacement
    Gavin Braithwaite; Fiscal Year: 2009
    ..Additionally, disc degeneration results in compromised biomechanics with frequent progression to disrupted spinal dynamics, osteoarthritis and spinal instability...
  68. KNEE STABILITY TRAINING IN INDIVDUALS WITH KNEE OSTEOARTHRITIS
    G Fitzgerald; Fiscal Year: 2007
    ..training) may improve the effectiveness of exercise therapy by inducing favorable changes in lower extremity biomechanics and allowing for greater improvements in functional status than what can be achieved by strength and joint ..
  69. CLINICAL BIOMECHANICS OF CERVICAL SPINE
    Manohar Panjabi; Fiscal Year: 1990
    ..Detaialed and quantified three-dimensional anatomy, using computer graphics; computer graphics (2) Biomechanics. Normal three-dimensional movements andphysical properties; (3) Instability...
  70. MULTISCAN PHOTON ABSORPTIOMETRY & OSTEOPOROTIC FRACTURE
    Wilson Hayes; Fiscal Year: 1991
    ..S., with estimated annual costs in excess of $10 billion. Despite this, the biomechanics of the osteoporotic state have been little studied and controversy exists on the most suitable procedure to ..
  71. Clinical Validation of BCT
    DAVID KOPPERDAHL; Fiscal Year: 2007
    ..A 3D biomechanics-based technique, which we term Biomechanical Computed Tomography (BCT), addresses this need through a ..
  72. BIOMECHANICS OF VERTEBRAL FRACTURES IN OSTEOPOROSIS
    WHITSON EDWARDS; Fiscal Year: 1991
    ..The eventual goals of these studies are to identify clinical predictors of the osteoporotic state, and to describe the progressive biomechanical changes in the strength of the thoracic and lumbar spine...
  73. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2000
    ..This BRP brings together the capabilities of an experienced computational biomechanics research group, four senior orthopaedic hip surgeons, a veterinary research orthopaedist, and an industry-based ..
  74. NIH-BIOMECHANICS IN MOVEMENT SCIENCE: BUILDING TRANSDOMAIN BRIDGES
    Irene S Davis; Fiscal Year: 2010
    Human movement is a product of the remarkably complex neuromusculoskeletal system. The field of Biomechanics and Movement Sciences is well poised to enhance the understanding of the broad array of neurologic and orthopedic human movement ..
  75. THE BIOMECHANICS OF OCCUPATIONAL SHOULDER INJURIES
    Andrew Karduna; Fiscal Year: 2001
    ..arm motion and shoulder disorders in the workplace, there are few scientific data available regarding the biomechanics of this connection...
  76. Mechanical System for Low Force Fatigue Tissue Testing
    Dawn M Elliott; Fiscal Year: 2010
    ..This instrument will be located in and managed by the Structure-Function Biomechanics Core of the Penn Center for Musculoskeletal Disorders...
  77. THE HYRAX AS A MODEL FOR FACIAL BIOMECHANICS AND GROWTH
    Marisa St Claire; Fiscal Year: 2000
    ..the utility and feasibility of the rock hyrax (Procavia capensis) as a laboratory model for aspects of facial biomechanics and growth relevant to the etiology and prevention of dental crowding and malocclusion...
  78. Tongue Volume, Function and Biomechanics
    Zi Jun Liu; Fiscal Year: 2006
    DESCRIPTION: The role of tongue in craniofacial function, biomechanics and growth is more critical than the larger jaw muscles but receives less attention. Thus knowledge of tongue functional morphology and loading is very rudimentary...