molecular biology

Summary

Summary: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.

Top Publications

  1. ncbi DAMBE: software package for data analysis in molecular biology and evolution
    X Xia
    Bioinformatics Laboratory, Department of Ecology and Biodiversity, University of Hong Kong, Pokfulam Road, Hong Kong
    J Hered 92:371-3. 2001
  2. ncbi The molecular biology of head and neck cancer
    C Rene Leemans
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Nat Rev Cancer 11:9-22. 2011
  3. ncbi Biomolecular simulation: a computational microscope for molecular biology
    Ron O Dror
    D E Shaw Research, New York, New York 10036, USA
    Annu Rev Biophys 41:429-52. 2012
  4. ncbi Molecular biology of flaviviruses
    Brett D Lindenbach
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, New York 10021, USA
    Adv Virus Res 59:23-61. 2003
  5. ncbi Advances in molecular biology of hibernation in mammals
    Matthew T Andrews
    Department of Biology, University of Minnesota Duluth, 1035 Kirby Drive, Duluth, MN 55812, USA
    Bioessays 29:431-40. 2007
  6. pmc Molecular biology of bcr-abl1-positive chronic myeloid leukemia
    Alfonso Quintas-Cardama
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:1619-30. 2009
  7. pmc The Gene Ontology (GO) database and informatics resource
    M A Harris
    GO EBI, Hinxton, UK
    Nucleic Acids Res 32:D258-61. 2004
  8. pmc The 2011 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection
    Michael Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 39:D1-6. 2011
  9. ncbi Computational systems biology
    Hiroaki Kitano
    Sony Computer Science Laboratories, Inc, Shinagwa, Tokyo, Japan
    Nature 420:206-10. 2002
  10. ncbi Advances in single-molecule fluorescence methods for molecular biology
    Chirlmin Joo
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Annu Rev Biochem 77:51-76. 2008

Research Grants

Detail Information

Publications262 found, 100 shown here

  1. ncbi DAMBE: software package for data analysis in molecular biology and evolution
    X Xia
    Bioinformatics Laboratory, Department of Ecology and Biodiversity, University of Hong Kong, Pokfulam Road, Hong Kong
    J Hered 92:371-3. 2001
    DAMBE (data analysis in molecular biology and evolution) is an integrated software package for converting, manipulating, statistically and graphically describing, and analyzing molecular sequence data with a user-friendly Windows 95/98/..
  2. ncbi The molecular biology of head and neck cancer
    C Rene Leemans
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Nat Rev Cancer 11:9-22. 2011
    ....
  3. ncbi Biomolecular simulation: a computational microscope for molecular biology
    Ron O Dror
    D E Shaw Research, New York, New York 10036, USA
    Annu Rev Biophys 41:429-52. 2012
    ....
  4. ncbi Molecular biology of flaviviruses
    Brett D Lindenbach
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, New York 10021, USA
    Adv Virus Res 59:23-61. 2003
  5. ncbi Advances in molecular biology of hibernation in mammals
    Matthew T Andrews
    Department of Biology, University of Minnesota Duluth, 1035 Kirby Drive, Duluth, MN 55812, USA
    Bioessays 29:431-40. 2007
    ....
  6. pmc Molecular biology of bcr-abl1-positive chronic myeloid leukemia
    Alfonso Quintas-Cardama
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:1619-30. 2009
    ..Herein, we synthesize the most relevant and current knowledge on such areas of the pathogenesis of CML...
  7. pmc The Gene Ontology (GO) database and informatics resource
    M A Harris
    GO EBI, Hinxton, UK
    Nucleic Acids Res 32:D258-61. 2004
    ..The GO Web resource also provides access to extensive documentation about the GO project and links to applications that use GO data for functional analyses...
  8. pmc The 2011 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection
    Michael Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 39:D1-6. 2011
    ..Acids Research features descriptions of 96 new and 83 updated online databases covering various areas of molecular biology. It includes two editorials, one that discusses COMBREX, a new exciting project aimed at figuring out the ..
  9. ncbi Computational systems biology
    Hiroaki Kitano
    Sony Computer Science Laboratories, Inc, Shinagwa, Tokyo, Japan
    Nature 420:206-10. 2002
    ..Computational systems biology addresses questions fundamental to our understanding of life, yet progress here will lead to practical innovations in medicine, drug discovery and engineering...
  10. ncbi Advances in single-molecule fluorescence methods for molecular biology
    Chirlmin Joo
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Annu Rev Biochem 77:51-76. 2008
    ..In this exciting era of transitioning from in vitro to in vivo and in situ conditions, it is anticipated that SM fluorescence methodology will become a common tool of molecular biology.
  11. ncbi The molecular biology of the CCAAT-binding factor NF-Y
    R Mantovani
    Dipartimento di Genetica e Biologia dei Microrganismi, Universita di Milano, Italy
    Gene 239:15-27. 1999
    ..This review focuses on the CCAAT sequence and on the NF-Y protein, also known as CBF, which binds to it...
  12. ncbi Myogenic satellite cells: physiology to molecular biology
    T J Hawke
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Appl Physiol 91:534-51. 2001
    ..We conclude by highlighting the potential therapeutic uses of satellite cells and identifying future research goals for the study of satellite cell biology...
  13. pmc The 2012 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection
    Michael Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 40:D1-8. 2012
    ..Issue of Nucleic Acids Research features descriptions of 92 new online databases covering various areas of molecular biology and 100 papers describing recent updates to the databases previously described in NAR and other journals...
  14. ncbi Molecular biology of inflammation and sepsis: a primer
    Ismail Cinel
    Division of Critical Care Medicine, The Robert Wood Johnson School of Medicine, The University of Medicine and Dentistry of New Jersey, Camden, NJ, USA
    Crit Care Med 37:291-304. 2009
    ..Remarkable progress has been made during the last decade in defining the molecular mechanisms that underlie septic shock. This rapidly expanding field is leading to new therapeutic opportunities in the management of severe sepsis...
  15. ncbi The molecular biology of coronaviruses
    Paul S Masters
    Wadsworth Center, New York State Department of Health, Albany, 12201, USA
    Adv Virus Res 66:193-292. 2006
    ..This review summarizes both classical and contemporary discoveries in the study of the molecular biology of these infectious agents, with particular emphasis on the nature and recognition of viral receptors, viral ..
  16. pmc MicroRNAs in colorectal cancer: translation of molecular biology into clinical application
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    Mol Cancer 8:102. 2009
    ..In this review, we summarize the knowledge regarding miRNAs' functioning in CRC while emphasizing their significance in pathogenetic signaling pathways and their potential to serve as disease biomarkers and novel therapeutic targets...
  17. ncbi The molecular biology of colorectal carcinoma and its implications: a review
    Sanjay Harrison
    Sunderland Royal Hospital, Kayll Road, Sunderland, SR4 7TP, UK
    Surgeon 9:200-10. 2011
    ..A medline and pubmed search was conducted using the keywords colorectal carcinoma, molecular biology of colorectal carcinoma, mutations, and the relevant articles were used for this review...
  18. pmc Basal cell carcinoma - molecular biology and potential new therapies
    Maria Kasper
    Karolinska Institutet, Center for Biosciences and Department of Biosciences and Nutrition, Novum, Huddinge, Sweden
    J Clin Invest 122:455-63. 2012
    ....
  19. ncbi Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention
    Jack P Shonkoff
    Center on the Developing Child, Harvard University, 50 Church St, Fourth Floor, Cambridge, MA 02138, USA
    JAMA 301:2252-9. 2009
    ....
  20. ncbi HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics
    Paola Gallinari
    Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM Merck Research Laboratories Rome, Pomezia, Italy
    Cell Res 17:195-211. 2007
    ..Since these processes are affected by malignant transformation, HDAC inhibitors were developed as antineoplastic drugs and are showing encouraging efficacy in cancer patients...
  21. ncbi Aging theories of primary osteoarthritis: from epidemiology to molecular biology
    T Aigner
    Osteoarticular and Arthritis Research Group, Department of Pathology, University of Erlangen Nurnberg, Germany
    Rejuvenation Res 7:134-45. 2004
    ....
  22. ncbi Molecular biology of choroidal neovascularization
    Ming Lu
    Vantage Eye Center, 622 Abbott Street, Salinas, CA 93901, USA
    Ophthalmol Clin North Am 19:323-34. 2006
    ..Safe and effective drug-delivery systems are also required for the successful anti-VEGF therapies for AMD and other ocular diseases with CNV...
  23. ncbi MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology
    Julio Vera
    Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany
    Adv Exp Med Biol 774:55-76. 2013
    ....
  24. ncbi Molecular biology of capsaicinoid biosynthesis in chili pepper (Capsicum spp.)
    Cesar Aza-González
    Departamento de Ingeniería Genética de Plantas, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Cinvestav Unidad Irapuato, Km 9 6 Libramiento Norte Carretera Irapuato León, 36821, Irapuato, Guanajuato, Mexico
    Plant Cell Rep 30:695-706. 2011
    ....
  25. pmc Integration of molecular biology tools for identifying promoters and genes abundantly expressed in flowers of Oncidium Gower Ramsey
    Chen Tran Hsu
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
    BMC Plant Biol 11:60. 2011
    ..However, model plants, such as Arabidopsis thaliana do not contain all plant genes, and agronomic and horticulturally important genera and species must be individually studied...
  26. pmc Molecular biology of K(ATP) channels and implications for health and disease
    Alejandro Akrouh
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    IUBMB Life 61:971-8. 2009
    ..Continuing studies of channel physiology and pathology will bring new insights to the molecular basis of K(ATP) channel function, leading to a better understanding of the role that K(ATP) channels play in both health and disease...
  27. ncbi Molecular biology and genetics of Alzheimer's disease
    Peter H St George-Hyslop
    Department of Medicine, Division of Neurology, The Toronto Hospital, University of Toronto, 6, Queen s Park Crescent West, Toronto, Ontario, Canada
    C R Biol 328:119-30. 2005
    ..Knowledge of this biochemical cascade now provides several potential targets for the development of diagnostics and therapeutics...
  28. ncbi Molecular biology of breast cancer stem cells: potential clinical applications
    Nam P Nguyen
    Department of Radiation Oncology, University of Arizona, N Campbell Ave, Tucson, AZ 85724 5081, USA
    Cancer Treat Rev 36:485-91. 2010
    ..The purpose of this study is to review breast CSCs molecular biology with respect to their mechanism of resistance to conventional therapy, and to develop treatment strategies ..
  29. ncbi Molecular biology of foamy viruses
    Axel Rethwilm
    Institut fur Virologie und Immunbiologie, University of Wurzburg, Versbacher Str 7, Wurzburg, Germany
    Med Microbiol Immunol 199:197-207. 2010
    ..The elucidation of the underlying basic mechanisms of the FV replication strategy is the topic of this review...
  30. pmc Molecular biology of PCSK9: its role in LDL metabolism
    Jay D Horton
    Departments of Internal Medicine and Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Trends Biochem Sci 32:71-7. 2007
    ..Although the mechanism of PCSK9 action is not yet clear, the protease provides a new therapeutic target to lower plasma levels of LDL and prevent CHD...
  31. ncbi Dinoflagellate mitochondrial genomes: stretching the rules of molecular biology
    Ross F Waller
    School of Botany, University of Melbourne, Melbourne, Victoria, Australia
    Bioessays 31:237-45. 2009
    ..Even after these processes, messenger RNAs (mRNAs) lack canonical start codons and most transcripts have abandoned stop codons altogether...
  32. ncbi Molecular biology and pathogenesis of viral myocarditis
    Mitra Esfandiarei
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Providence Health Care Research Institute, Vancouver, Canada
    Annu Rev Pathol 3:127-55. 2008
    ..Advances in genomics and proteomics, and in the use of informatics and biostatistics, are allowing unbiased initial evaluations that can be the basis for testable hypotheses about virus pathogenesis and new therapies...
  33. ncbi The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms
    Colin Ratledge
    Lipid Research Centre, Department of Biological Sciences, University of Hull, HU6 7RX, United Kingdom
    Adv Appl Microbiol 51:1-51. 2002
  34. pmc Codon-optimized fluorescent proteins designed for expression in low-GC gram-positive bacteria
    Inka Sastalla
    Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 33, Bethesda, MD 20892 3202, USA
    Appl Environ Microbiol 75:2099-110. 2009
    ..Using optimized GFP as a reporter, we were able to monitor the activity of the protective antigen promoter of B. anthracis and confirm its dependence on bicarbonate and regulators present on virulence plasmid pXO1...
  35. ncbi Molecular biology of glioma
    Tomotoshi Marumoto
    Department of Molecular Genetics, Medical Institute of Bioregulation, Fukuoka, Japan
    Adv Exp Med Biol 746:2-11. 2012
    ..Here, we describe recent advances in the understanding of the biology of GBMs...
  36. pmc 18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterization
    Hossein Jadvar
    Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 50:1820-7. 2009
    ..of this review is to bring together and summarize the current data on the correlation between the underlying molecular biology and the clinical observations of tumor (18)F-FDG accumulation in 3 major human cancers: lung, breast, and ..
  37. pmc Microscopy and molecular biology for the diagnosis and evaluation of malaria in a hospital in a rural area of Ethiopia
    María A Santana-Morales
    University Institute of Tropical Diseases and Public Health of the Canary Islands University of La Laguna, Tenerife, Spain
    Malar J 11:199. 2012
    ..The aim of the present work was to compare different malaria diagnostic methods in order to detect the most common species of Plasmodium and to broaden the knowledge of malaria prevalence in a hospital in a rural area in Ethiopia...
  38. pmc NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome
    Alessandro De Luca
    CSS Hospital, IRCCS, San Giovanni Rotondo and CSS Mendel Institute, Rome, Italy
    Am J Hum Genet 77:1092-101. 2005
    ..These results support the view that NFNS represents a variant of NF1 and is caused by mutations of the NF1 gene, some of which have been demonstrated to cause classic NF1 in other individuals...
  39. ncbi PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage
    Todd Charlton Sacktor
    The Robert F Furchgott Center for Neural and Behavioral Science, Departments of Physiology, Pharmacology, and Neurology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Prog Brain Res 169:27-40. 2008
    ..Similar results are found for conditioned taste aversion when the inhibitor is injected in the insular neocortex. Thus PKMzeta is the first molecule found to be a component of the long-term memory trace...
  40. ncbi The use of molecular biology in diagnosis and prognosis of gastric cancer
    K F Becker
    Technische Universitaet Muenchen, Klinikum rechts der Isar, Institut fuer Pathologie, Munich, Germany
    Surg Oncol 9:5-11. 2000
    ..The clinical implications of the recent findings for diagnosis, prognosis, therapy, and risk assessment are discussed...
  41. ncbi Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology
    Daniela Stock
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Prog Biophys Mol Biol 88:311-27. 2005
    ..The methods described are now used almost exclusively for obtaining diffraction quality crystals in our laboratory with a throughput of several thousand plates per year. Our set-up has been copied in many institutions worldwide...
  42. ncbi Oxidation and age-related macular degeneration: insights from molecular biology
    Sam Khandhadia
    Clinical Neurosciences Division, School of Medicine, University of Southampton, UK
    Expert Rev Mol Med 12:e34. 2010
    ..This article reviews the role of oxidative stress in AMD and the potential therapies that might have a role in preventing the blindness resulting from this disease...
  43. ncbi Molecular biology of bladder cancer
    Nuno M Luis
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Clin Transl Oncol 9:5-12. 2007
    ..Distinct gene expression profiles have been identified in superficial and invasive tumors. The stage is now ready for the clinical application of this knowledge...
  44. pmc Does the committee peer review select the best applicants for funding? An investigation of the selection process for two European molecular biology organization programmes
    Lutz Bornmann
    Social Psychology and Research on Higher Education, ETH Zurich, Zurich, Switzerland
    PLoS ONE 3:e3480. 2008
    ..this question we analyzed the Long-Term Fellowship and the Young Investigator programmes of the European Molecular Biology Organization...
  45. pmc A survey of current software for network analysis in molecular biology
    Sterling Thomas
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, 23284 2030, USA
    Hum Genomics 4:353-60. 2010
    ..A comparative test evaluated how these software packages perform the search for key terms and the creation of network from those terms and from experimental expression data...
  46. ncbi Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus
    Subhash C Verma
    Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    FEMS Microbiol Lett 222:155-63. 2003
    ..LANA has now been shown to be a multifunctional protein involved in numerous cellular functions including binding to the retinoblastoma protein and p53, regulating cell proliferation and apoptosis...
  47. ncbi Molecular biology of apolipoprotein E
    Warren J Strittmatter
    Deane Laboratory, Division of Neurology, Duke Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Lipidol 13:119-23. 2002
    ....
  48. pmc Lung cancer. 9: Molecular biology of lung cancer: clinical implications
    K M Fong
    The Prince Charles Hospital, Rode Road, Chermside, Brisbane 4032, Australia
    Thorax 58:892-900. 2003
    ..This notion has important clinical ramifications. Recent developments in our knowledge of the molecular biology of lung cancer are reviewed, with particular reference to genetic abnormalities in tumour suppressor gene ..
  49. ncbi Molecular biology of hepatitis C virus
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Tokyo, Japan
    J Gastroenterol 42:411-23. 2007
    ..This review summarizes the current knowledge of cell culture systems for HCV research and recent advances in the investigation of the molecular virology of HCV...
  50. ncbi Insect olfactory receptors: contributions of molecular biology to chemical ecology
    Emmanuelle Jacquin-Joly
    Equipe Communication Chimique, Unité de Phytopharmacie et des Médiateurs Chimiques, INRA, Versailles, France
    J Chem Ecol 30:2359-97. 2004
    ....
  51. ncbi Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
    Louis M Luttrell
    Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 816 CSB, P O Box 250624, Charleston, SC 29425, USA
    Mol Biotechnol 39:239-64. 2008
    ..While the physiologic relevance of many of these novel mechanisms of GPCR signaling remains to be established, their existence suggests that the mechanisms of GPCR signaling are even more diverse than previously imagined...
  52. ncbi The protein meta-structure: a novel concept for chemical and molecular biology
    Robert Konrat
    Department of Structural and Computational Biology, Max F Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, 1030, Vienna, Austria
    Cell Mol Life Sci 66:3625-39. 2009
    ..In this review some prototypical applications will be presented that serve to illustrate the potential of the methodology...
  53. pmc Inteins, valuable genetic elements in molecular biology and biotechnology
    Skander Elleuche
    Institute of Technical Microbiology, Technical University Hamburg Harburg, Kasernenstr 12, 21073, Hamburg, Germany
    Appl Microbiol Biotechnol 87:479-89. 2010
    ..This review summarizes the catalytic activities and structures of inteins, and focuses on the advantages of some recent intein applications in molecular biology and biotechnology.
  54. ncbi Cell and molecular biology of invadopodia
    Giusi Caldieri
    Tumor Cell Invasion Laboratory, Chieti, Italy
    Int Rev Cell Mol Biol 275:1-34. 2009
    ..Current knowledge will be reviewed here together with some of the most important open questions in invadopodia biology...
  55. ncbi Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives
    L Annunziato
    Division of Pharmacology, Department of Neuroscience, School of Medicine, Federico II University of Naples, Via S Pansini, 5 80131 Naples, Italy
    Pharmacol Rev 56:633-54. 2004
    ..b>Molecular biology, electrophysiology, genetically modified mice, and molecular pharmacology have helped to delve deeper and ..
  56. pmc How restriction enzymes became the workhorses of molecular biology
    Richard J Roberts
    New England Biolabs, 32 Tozer Road, Beverly, MA 01915, USA
    Proc Natl Acad Sci U S A 102:5905-8. 2005
    ..This pioneering study set the stage for the modern practice of molecular biology in which restriction enzymes are ubiquitous tools, although they are often taken for granted.
  57. pmc Nonparametric methods for molecular biology
    Knut M Wittkowski
    Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA
    Methods Mol Biol 620:105-53. 2010
    ....
  58. ncbi Update on the molecular biology of malignant mesothelioma
    Amie Y Lee
    Department of Surgery, Division of Cardiothoracic Surgery, University of California, San Francisco, California 94143, USA
    Cancer 109:1454-61. 2007
    ..Improvement in our understanding of the molecular biology of MM has identified promising new candidates for targeted treatments...
  59. ncbi The growing contributions of molecular biology and immunology to protistan ecology: molecular signatures as ecological tools
    David A Caron
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0371, USA
    J Eukaryot Microbiol 51:38-48. 2004
    ..These issues include the highly technical nature of some of the molecular methods, the reconciliation of morphology-based and sequence-based species identifications, and the species concept itself...
  60. pmc A molecular genetics laboratory course applying bioinformatics and cell biology in the context of original research
    Cynthia J Brame
    Department of Biology, Centenary College of Louisiana, Shreveport, LA 71105, USA
    CBE Life Sci Educ 7:410-21. 2008
    ..The project was designed to allow students to become familiar with the use of bioinformatics tools and molecular biology and genetic approaches while carrying out original research...
  61. pmc Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Serge Patrick Nana-Sinkam
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, Columbus, OH, USA
    Chest 143:e30S-9S. 2013
    ..We focus on research developments in the understanding of lung cancer somatic DNA mutations, chromosomal aberrations, epigenetics, and the tumor microenvironment, and how they can advance diagnostics and therapeutics...
  62. ncbi Prokaryotic toxin-antitoxin systems--the role in bacterial physiology and application in molecular biology
    Michal Bukowski
    Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Acta Biochim Pol 58:1-9. 2011
    ..The impact of toxin-antitoxin systems on bacteria physiology prompted their application in molecular biology as tools allowing cloning of some hard-to-maintain genes, plasmid maintenance and production of recombinant ..
  63. ncbi Signet-ring cell carcinoma of colorectum--current perspectives and molecular biology
    Vinod Gopalan
    School of Medicine, Griffith Health Institute, Gold Coast, QLD, Australia
    Int J Colorectal Dis 26:127-33. 2011
    Colorectal signet-ring cell carcinoma (SRCC) is rare, and very little detailed information on the molecular biology of the disease is available.
  64. pmc Molecular biology of pancreatic cancer
    Miroslav Zavoral
    Charles University, 1st Medical Faculty, Internal Clinic, 128 00 Prague 2, Czech Republic
    World J Gastroenterol 17:2897-908. 2011
    ..Understanding of the underlying molecular mechanisms should promote development of new methodology for early diagnosis and facilitate improvement in current approaches for pancreatic cancer treatment...
  65. pmc Complete in vitro life cycle of Trypanosoma congolense: development of genetic tools
    Virginie Coustou
    Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, UMR 5234 CNRS, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    PLoS Negl Trop Dis 4:e618. 2010
    ....
  66. pmc Educational challenges of molecular life science: Characteristics and implications for education and research
    Lena A E Tibell
    Department of Science and Technology, Linkoping University, Norrkoping, Sweden
    CBE Life Sci Educ 9:25-33. 2010
    ..Of these challenges, we focus most detail on content, reasoning difficulties, and communication issues. We also discuss implications for education research and teaching in the molecular life sciences...
  67. ncbi Molecular biology of therapy-related leukaemias
    Melanie Joannides
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Clin Transl Oncol 12:8-14. 2010
    ..Although treatment of therapy-related leukaemias represents a considerable challenge due to prior therapy and comorbidities, curative therapy is possible, particularly in those with favourable karyotypic features...
  68. pmc Proteomics, genomics, and molecular biology in the personalized treatment of colorectal cancer
    John M Carethers
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, 3901 Taubman Center, SPC 5368, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5368, USA
    J Gastrointest Surg 16:1648-50. 2012
    ..Utilizing stool, blood/plasma, and tumor tissue to obtain genetic, genomic, and pharmacokinetic information contribute to a person's profile to direct specific cancer care...
  69. ncbi Understanding the molecular biology of myeloma and its therapeutic implications
    Kevin D Boyd
    The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey, UK
    Expert Rev Hematol 5:603-17. 2012
    ..This review explores the molecular biology of myeloma and identifies how genetic lesions can be used to define high- and low-risk patient groups, and ..
  70. ncbi Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-β- synthase (CBS) and cystathionine-γ-lyase (CSE)
    Barbara Renga
    Department of Experimental and Clinical Medicine, Street E, dal Pozzo, Pad W, University of Perugia, Perugia, Italy
    Inflamm Allergy Drug Targets 10:85-91. 2011
    ....
  71. pmc Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization
    Thomas G Schulze
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD 20892 3719, USA
    Psychiatr Clin North Am 33:67-82. 2010
    ..It furthermore sketches out a potential research framework integrating various lines of research into the molecular biological basis of BD...
  72. ncbi Assessment of various methods for extraction of metagenomic DNA from saline habitats of coastal Gujarat (India) to explore molecular diversity
    M K Purohit
    Department of Biosciences, Saurashtra University, Rajkot, Gujarat, India
    Lett Appl Microbiol 49:338-44. 2009
    ..To develop total DNA extraction protocol from saline soil for further metagenomic applications...
  73. ncbi Molecular biology of Huntington's disease
    Karen N McFarland
    Department of Neurology, University of Florida, Gainesville, FL 32610 0236, USA
    Handb Clin Neurol 100:25-81. 2011
    ..We also highlight potential pathogenic mechanisms that have come to light in recent years...
  74. pmc Factor correction as a tool to eliminate between-session variation in replicate experiments: application to molecular biology and retrovirology
    Jan M Ruijter
    Department of Anatomy and Embryology, Academic Medical Centre, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Retrovirology 3:2. 2006
    In experimental biology, including retrovirology and molecular biology, replicate measurement sessions very often show similar proportional differences between experimental conditions, but different absolute values, even though the ..
  75. pmc Implementation of a project-based molecular biology laboratory emphasizing protein structure-function relationships in a large introductory biology laboratory course
    Daniel J Treacy
    Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA
    CBE Life Sci Educ 10:18-24. 2011
    ..This laboratory utilizes basic techniques in molecular biology to emphasize the importance of connections between DNA and protein...
  76. ncbi Sample size and power calculation for molecular biology studies
    Sin Ho Jung
    Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA
    Methods Mol Biol 620:203-18. 2010
    ..In this chapter, we consider molecular biology studies generating huge dimensional data...
  77. ncbi Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention
    Maria Sereno
    Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid, Spain
    Clin Transl Oncol 13:599-610. 2011
    ..In this review, we describe briefly the most important aspects related to clinical features, molecular biology and strategies for prevention in hereditary gastric associated to different cancer syndromes.
  78. pmc Functional characterisation of metal(loid) processes in planta through the integration of synchrotron techniques and plant molecular biology
    Erica Donner
    Centre for Environmental Risk Assessment and Remediation, University of South Australia, Building X, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia
    Anal Bioanal Chem 402:3287-98. 2012
    ..This article focuses on the benefits of combining molecular biology and synchrotron-based techniques...
  79. ncbi Vectors for improved Tet repressor-dependent gradual gene induction or silencing in Staphylococcus aureus
    Leonie Helle
    Lehrbereich Mikrobielle Genetik, Eberhard Karls Universitat Tubingen, Interfakultäres Institut für Mikrobiologie und Infektionsmedizin, Tubingen, Germany
    Microbiology 157:3314-23. 2011
    ..Intriguingly, revtetR was found to contain a fourth mutation only after propagation in S. aureus. We predict that the described vectors constitute valuable tools for staphylococcal genetics...
  80. ncbi Molecular biology of chronic thromboembolic pulmonary hypertension
    Richard S Sacks
    Department of Medicine, University of California, San Diego, La Jolla 92093 0725, USA
    Semin Thorac Cardiovasc Surg 18:265-76. 2006
    ..Other articles in this series describe the pathological, surgical, and therapeutic aspects of CTEPH. Here, we review the potential molecular and cellular mechanisms that may contribute to the pathogenesis of CTEPH...
  81. ncbi Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
    Kumar Sambamurti
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neuromolecular Med 1:1-31. 2002
    ..The present review summarizes our current understanding of APP metabolism and function and their relationship to other proteins involved in AD...
  82. ncbi Ependymomas of the adult: molecular biology and treatment
    Roberta Ruda
    Division of Neuro Oncology, Department of Neuroscience, University and San Giovanni Battista Hospital, Turin, Italy
    Curr Opin Neurol 21:754-61. 2008
    To review state of art and relevant advances in the molecular biology and management of ependymomas of the adult.
  83. ncbi Modelling the molecular circuitry of cancer
    William C Hahn
    Whitehead Institute for Biomedical Research, Massachusetts 02142, USA
    Nat Rev Cancer 2:331-41. 2002
    ....
  84. ncbi Artificial chemokines: combining chemistry and molecular biology for the elucidation of interleukin-8 functionality
    Ralf David
    Institut fur Biochemie, Fakultat fur Biowissenschaften, Pharmazie and Psychologie, Universitat Leipzig, Bruderstrasse 34, D 04103 Leipzig, Germany
    J Am Chem Soc 130:15311-7. 2008
    ..Concepts like this could be a first step toward the synthesis of proteins consisting of large artificial secondary structure elements...
  85. ncbi Defining the molecular biology of inflammatory breast cancer
    Emmanuelle Charafe-Jauffret
    Département d Oncologie Moléculaire, Institut Paoli Calmettes and UMR599 INSERM, IFR137, 232 Boulevard Sainte Marguerite, Marseille Cedex 09, France
    Semin Oncol 35:41-50. 2008
    ..The aim of this review is to present and discuss what is known about the biology of this particularly aggressive form of breast cancer and to discuss how this knowledge could improve its management...
  86. ncbi The microenvironment and molecular biology of the multiple myeloma tumor
    Miguel Lemaire
    Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Adv Cancer Res 110:19-42. 2011
    ....
  87. ncbi Molecular biology of basal and squamous cell carcinomas
    Jingwu Xie
    Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1048, USA
    Adv Exp Med Biol 624:241-51. 2008
    ..In this chapter, we will focus on major recent developments in our understanding of basal cell carcinomas and squamous cell carcinomas at the molecular levels and their clinical implications...
  88. ncbi The molecular biology and clinical features of amyloid neuropathy
    Merrill D Benson
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, MS 128, Indianapolis, IN 46202 5126, USA
    Muscle Nerve 36:411-23. 2007
    ..Proposed gene therapy with antisense oligonucleotides (ASOs) to suppress hepatic transthyretin synthesis is effective in a transgenic mouse model but has not yet been tested in humans...
  89. ncbi Pediatric ependymomas: will molecular biology change patient management?
    Jacques Grill
    Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, Villejuif, France
    Curr Opin Oncol 23:638-42. 2011
    ..Ependymomas remain a therapeutic challenge in pediatric neuro-oncology. These tumors are chemoresistant and rather radioresistant and until recently little was known about their biology...
  90. ncbi Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cells
    Roman K Thomas
    Molecular Tumor Biology and Tumor Immunology group, Department I of Internal Medicine, University of Cologne, Germany
    Lancet Oncol 5:11-8. 2004
    ....
  91. ncbi Therapeutic consequences from molecular biology for gastrointestinal stromal tumor patients affected by neurofibromatosis type 1
    Chiara Mussi
    Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, Germany
    Clin Cancer Res 14:4550-5. 2008
    ..The lack of data on imatinib activity raises the question whether to enroll these patients in clinical trials. We analyzed a large series of NF-1 related GISTs to discuss the therapeutic implications...
  92. ncbi The Boltzmann equation in molecular biology
    Jean Marc Dubois
    CNRS, Institut de Neurobiologie Alfred Fessard FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire UPR9040, Gif sur Yvette F 91198, France
    Prog Biophys Mol Biol 99:87-93. 2009
    ..The aim of this review is to trace the history of the developments of the Boltzmann equation that account for the behaviour of proteins involved in molecular biology and physiology.
  93. doi Molecular biology: the expanding world of small RNAs
    Helge Grosshans
    Nature 451:414-6. 2008
  94. ncbi Molecular biology of the baculovirus occlusion-derived virus envelope
    Sharon C Braunagel
    Department of Entomology, Texas A and M University, Texas Agricultural Experiment Station, College Station, TX 77843, USA
    Curr Drug Targets 8:1084-95. 2007
    ..The composition of ODV is reviewed, however it is worth noting that the function of many ODV proteins are currently unknown...
  95. ncbi An overview of clustering applied to molecular biology
    Rebecca Nugent
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA
    Methods Mol Biol 620:369-404. 2010
    In molecular biology, we are often interested in determining the group structure in, e.g., a population of cells or microarray gene expression data...
  96. ncbi Physiology and molecular biology of renal carbonic anhydrase
    George J Schwartz
    Pediatric Nephrology, University of Rochester School of Medicine, NY 14642, USA
    J Nephrol 15:S61-74. 2002
    ..To establish other roles for CA in the kidney will require further kinetic, functional, immunolocalization and cloning studies...
  97. ncbi Combined eco-epidemiological and molecular biology approaches to assess Echinococcus granulosus transmission to humans in Mauritania: occurrence of the 'camel' strain and human cystic echinococcosis
    K Bardonnet
    WHO Collaborating Centre for Prevention and Treatment of Human Echinococcosis, Research Unit Health and Rural Environment, University of Franche Comté SERF, School of Medicine and Pharmacy, 25 030 Besançon, France
    Trans R Soc Trop Med Hyg 96:383-6. 2002
    ..animal reservoir responsible for human CE emerging in Mauritania, a simultaneous eco-epidemiological and molecular biology approach was performed...
  98. ncbi Molecular biology of insect olfaction: recent progress and conceptual models
    M Rutzler
    Department of Biological Sciences, Program in Developmental Biology and Center for Molecular Neuroscience, Vanderbilt University, VU Station B 351634, Nashville, TN 37235 3582, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:777-90. 2005
    ..This review intends to summarize much of this progress and to point out some areas where advances can be expected in the near future...
  99. ncbi Cell and molecular biology of microtubule plus end tracking proteins: end binding proteins and their partners
    Susana Montenegro Gouveia
    Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    Int Rev Cell Mol Biol 285:1-74. 2010
    ....
  100. ncbi Biochemistry and molecular biology of trophoblast invasion
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Switzerland
    Ann N Y Acad Sci 943:157-62. 2001
    ..This review is not intended to be an exhaustive catalogue of potential regulators of trophoblast invasion but is aimed at summarizing the most important categories of factors affecting trophoblast-endometrium interactions...
  101. ncbi Effects of systemic interleukin-10 therapy on psoriatic skin lesions: histologic, immunohistologic, and molecular biology findings
    K Asadullah
    Institute of Medical Immunology and Department of Dermatology, University Hospital Charite, Berlin Humboldt University, Berlin, Germany
    J Invest Dermatol 116:721-7. 2001
    ..Our findings demonstrate considerable effects of systemic interleukin-10 application on the skin immune systems, which might contribute to the anti-psoriatic activity of interleukin-10...

Research Grants62

  1. Identification and Analysis of Circadian Clock-Controlled Genes
    Jennifer J Loros; Fiscal Year: 2013
    ..abstract_text> ..
  2. CpnA's role in cAMP signaling and the actin cytoskeleton in Dictyostelium
    Cynthia K Damer; Fiscal Year: 2013
    ..Increasing our scientific knowledge of how copines function could lead to a better understanding of cancer and immune cell-related diseases. ..
  3. Metabolic regulation in growth factor-dependent cells
    Ralph J DeBerardinis; Fiscal Year: 2010
    ....
  4. VACCINIA VIRUS BIOCHEMICAL GENETICS
    Richard C Condit; Fiscal Year: 2013
    ....
  5. Genome Persistence of KSHV
    Erle S Robertson; Fiscal Year: 2013
    ....
  6. TRAINING GRANT IN GENETICS
    CYNTHIA CASSON MORTON; Fiscal Year: 2013
    ....
  7. MEDICAL GENETICS RESEARCH FELLOWSHIP PROGRAM
    BRENDAN HL LEE; Fiscal Year: 2013
    ....
  8. Subcellular architecture of regulatory protein complexes at the bacterial pole
    LUCILLE SHAPIRO; Fiscal Year: 2013
    ..Dynamical information in live cells will be extracted from imaging at differen times of the cell cycle, thus providing an unprecedented view of the structure as well as the dynamics controlling bacterial cell organization and function. ..
  9. CryoEM Structural Studies of DNA-PKcs and Nonhomologous End Joining Complexes
    Phoebe L Stewart; Fiscal Year: 2013
    ..Ultimately this information will be helpful in understanding and treating cancer, severe combined immune deficiency (SCID), and sensitivity to ionizing radiation (RS-SCID). ..
  10. Promoting genetic literacy in students and teachers: The effectiveness of non-cla
    LETA MEOLE TRIBBLE; Fiscal Year: 2010
    ....
  11. NOVEL TECHNOLOGIES IN NEWBORN SCREENING
    M D MATERN; Fiscal Year: 2012
    ..Also with support from NICHD, these assays are tested in a prospective comparative effectiveness study to determine the most efficient and effective approach to newborn screening for these conditions. ..
  12. MEDICAL GENETICS RESEARCH TRAINING GRANT
    Ian D Krantz; Fiscal Year: 2013
    ..has a substantial clinical load and fulfills a portion of her/his didactic course work in human genetics and molecular biology. This first year is funded by the University of Pennsylvania School of Medicine and The Children's ..
  13. California Center of the NBDPS - Finding Causes and Preventives of Birth Defects
    GARY C SHAW; Fiscal Year: 2013
    ....
  14. UCLA Intercampus Medical Genetics Training Program
    LAURENCE HERBERT KEDES; Fiscal Year: 2013
    ..The faculty of this program provides research opportunities varying from basic molecular biology, genomics, cell biology, stem cell research, biochemical genetics, cytogenetics, population genetics, to ..
  15. MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES
    ROBERT DESNICK; Fiscal Year: 2007
    ..There is interdisciplinary input which has been enhanced by the addition of outstanding faculty in molecular biology, neurobiology, cell biology, bioinformatics, and gene therapy, areas of recent institutional growth and ..
  16. MOLECULAR AND SOMATIC CELL MAPPING OF DEER MOUSE GENES
    DUKE ROGERS; Fiscal Year: 1991
    ..to protect gene combinations within these regions? 2) Is chromosome banding similarity among species indicative of underlying genic similarity; and 3) Have portions of the mammalian genome been conserved by chance or by selection?..
  17. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..We will use biochemical, genetics and functional assays to assess the relevance in Arenavirus biology of candidates initially identified by TAP/MS. ..
  18. INFRASTRUCTURE FOR RESEARCH ON MENTAL DISABILITIES
    Roger Stevenson; Fiscal Year: 2003
    ....
  19. BIOCHEMICAL GENETICS OF CELLULAR CHOLESTEROL METABOLISM
    Michael Sinensky; Fiscal Year: 1993
    ..It is anticipated that these studies will aid in the development of chemotherapeutic methods towards management of atherosclerosis as well as shedding new light on the possible function of epoxysterols...
  20. MOLECULAR GENETIC BASIS OF HUMAN DISEASE
    Robb Moses; Fiscal Year: 2005
    ..The variety of research programs and the maturity of the clinical activities of the Department will allow the program to meet its goals. ..
  21. IMMUNOCHEMICAL GENETICS OF MURINE ALLOANTIGENS
    James Michaelson; Fiscal Year: 1991
    ....
  22. BIOCHEMICAL GENETICS AND STAT2 IN IFN SIGNALING
    Christian Schindler; Fiscal Year: 1999
    ..Specifically we propose to: 1. Create a Stat2 knock out mouse. 2. Carry out a functional comparison of the murine and human Stat2 homologs. 3. Identify the DNA binding elements for Stat2 homodimers. ..
  23. NEUROSTEROIDOGENESIS IN NIEMANN-PICK TYPE C DISEASE
    Lisa Griffin; Fiscal Year: 2001
    ..The candidate's research background is in biochemical genetics and molecular biology with long term interest in molecular developmental neurobiology...
  24. BIOCHEMICAL GENETICS OF NATURAL POPULATIONS
    ROBERT SELANDER; Fiscal Year: 1980
    ..The research is expected to yield results important in determing the bases for the maintenance of molecular polymorphism in natural populations of organisms. Much of the work deals with the bacterium Escherichia coli...
  25. BIOCHEMICAL GENETICS OF MALE SEXUAL DETERMINATION
    Robert Erickson; Fiscal Year: 1992
    ..Thus, we believe that our studies of sex determination both increase our understanding of mammalian development and provide clinically useful material to aid patients seen in genetics and endocrine clinics...
  26. BIOCHEMICAL GENETICS OF DEVELOPMENT IN DROSOPHILA
    HERSCHEL MITCHELL; Fiscal Year: 1990
    ..We plan to continue exploration of this interesting property of several of the proteins we are dealing with...
  27. Collaborative Genetics Research Training Program
    ETHYLIN JABS; Fiscal Year: 2006
    ..in Genetic Counseling, or research laboratory training, some of whom may obtain certification in Clinical Molecular Biology, Biochemical Genetics, or Cytogenetics. Predoctoral students will enroll in degree programs for a Ph.D...
  28. BIOCHEMICAL GENETICS OF CARBONIC ANHYDRASE DEFICIENCIES
    William Sly; Fiscal Year: 2008
    ..The answers sought have fundamental significance, and should provide information leading to novel therapeutic approaches to CA deficiency. ..
  29. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  30. HORMONAL AND ZINC REGULATION OF PROSTATE M ACONITASE
    LES COSTELLO; Fiscal Year: 2004
    ..This information will provide new approaches to the diagnosis, prevention, and treatment of PCa. ..
  31. STRUCTURE AND FUNCTION OF MEMBRANE PROTEINS
    William Dowhan; Fiscal Year: 2004
    ..The proposed experiments are expected to define at the molecular level the role of PE and other lipids in the assembly, organization, and function of polytopic membrane proteins. ..
  32. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2004
    ....
  33. TESTING THE VALIDITY OF ADULT ATTENTION DEFICIT DISORDER
    Stephen Faraone; Fiscal Year: 2002
    ..Thus, if founded, we expect that the proposed work will lead to a program of research that can both clarify the nosological complexities of adult ADHD and clarify the nature of genes that are risk factors for the disorder. ..
  34. 12th International Symposium on Basement Membranes
    Jouni Uitto; Fiscal Year: 2005
    ..In that sense, the meeting will meet some of the goals of the National Institutes of Health Roadmap Initiative. ..
  35. Structural Studies of Transcriptional Regulators
    Mitchell Lewis; Fiscal Year: 2011
    ..In the future a modified lac repressor could be used to regulate a variety of promoters. Endogenous loci could be switched on and off to create reversible models of human disease and normal development. ..
  36. Analysis of an ADHD Whole Genome Association Scan
    Stephen Faraone; Fiscal Year: 2007
    ..All genotype data generated by the GAIN whole genome association scan will be made available to the scientific community by GAIN as soon as the genotypes are completed. [unreadable] [unreadable] [unreadable]..
  37. A Twin-Family Study of Drug Use, Abuse, and Dependence
    Kenneth Kendler; Fiscal Year: 2007
    ..abstract_text> ..
  38. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2008
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  39. PROGRAM PROJECT GRANT
    Jouni Uitto; Fiscal Year: 2006
    ..abstract_text> ..
  40. 2/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses
    Stephen Faraone; Fiscal Year: 2008
    ..Finally, the PGC proposes to abide as fully as possible with the NIH's GWAS data sharing policies and we provide a detailed data sharing plan and timetable. [unreadable] [unreadable] [unreadable]..
  41. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..mice combined with pathophysiological in vitro and in vivo studies will provided new insight in the molecular biology of mucin-type O-glycosylation and its intriguing role in ectopic calcium crystal deposition disorders...
  42. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  43. ASN Workshop "In Vivo MR Tracking of Stem Cells in the CNS" (R13)
    JEFF BULTE; Fiscal Year: 2005
    ..The outcome of the workshop will be published in Experimental Neurology and available for the scientific community at large. ..
  44. An Irish Affected Sib Pair Study of Alcohol Dependence
    Kenneth Kendler; Fiscal Year: 2005
    ..To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics...
  45. Validating Novel Familial Phenotypes of Drug Abuse
    Stephen Faraone; Fiscal Year: 2007
    ..State of the art statistical techniques will be employed. ..