mhc class ii genes

Summary

Summary: Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.

Top Publications

  1. ncbi Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes
    Salome Leibundgut-Landmann
    Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 34:1513-25. 2004
  2. pmc Mice lacking all conventional MHC class II genes
    L Madsen
    Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 96:10338-43. 1999
  3. ncbi CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter
    G W Beresford
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 2:652-7. 2001
  4. ncbi Genetic control of MHC class II expression
    Jenny Pan Yun Ting
    Department of Microbiology and Immunology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 109:S21-33. 2002
  5. ncbi MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci
    Unni Grimholt
    Department of Morphology, Genetics and Aquatic Biology, Section of Genetics, Norwegian School of Veterinary Science, Ullevaalsveien 72, P O Box 8146 Dep, 0033 Oslo, Norway
    Immunogenetics 55:210-9. 2003
  6. ncbi Clinal variation in MHC diversity with temperature: evidence for the role of host-pathogen interaction on local adaptation in Atlantic salmon
    Mélanie Dionne
    Departement de Biologie, Universite Laval, Quebec, G1K 7P4, Canada
    Evolution 61:2154-64. 2007
  7. ncbi The role of mhc polymorphism in anti-microbial resistance
    Janko Nikolich-Zugich
    Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center of the Oregon Health, Science University, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Microbes Infect 6:501-12. 2004
  8. ncbi Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
    C H Chang
    Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 4:167-78. 1996
  9. ncbi Parasite burden and constitution of major histocompatibility complex in the Malagasy mouse lemur, Microcebus murinus
    J Schad
    Department of Animal Ecology and Conservation, University of Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Evolution 59:439-50. 2005
  10. ncbi Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics
    C Tollenaere
    INRA EFPA, UMR CBGP INRA IRD Cirad Montpellier SupAgro, Campus International de Baillarguet, Montferrier sur Lez CEDEX, France
    J Evol Biol 21:1307-20. 2008

Research Grants

  1. Regulation of MHC Class II Genes
    Jeremy M Boss; Fiscal Year: 2013
  2. MHC Class II Transactivator Function and Regulation
    JEREMY BOSS; Fiscal Year: 2009
  3. Testing mechanisms of parasite-mediated selection on MHC genetic diversity
    JILLIAN TIKKA DETWILER; Fiscal Year: 2013
  4. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
  5. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001
  6. ISOLATION OF CDNA'S FOR HLA CLASS II TRANSACTING FACTORS
    Benjamin Schwartz; Fiscal Year: 1992
  7. IMMUNOBIOLOGY OF MHC CLASS II TRANSACTIVATOR
    Cheong Hee Chang; Fiscal Year: 2001
  8. PEPTIDE EPITOPES PRESENTED IN AUTOIMMUNE DIABETES
    Samuel Wilson; Fiscal Year: 1999
  9. STRUCTURAL BASIS OF FUNCTIONAL CLASS II GENE EXPRESSION
    Laurie Glimcher; Fiscal Year: 2001
  10. STRUCTURAL BASIS OF FUNCTIONAL CLASS II GENE EXPRESSION
    Laurie Glimcher; Fiscal Year: 1992

Detail Information

Publications226 found, 100 shown here

  1. ncbi Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes
    Salome Leibundgut-Landmann
    Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 34:1513-25. 2004
    ....
  2. pmc Mice lacking all conventional MHC class II genes
    L Madsen
    Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 96:10338-43. 1999
    ..Therefore, they should be invaluable for engineering "humanized" mouse models of human MHC-II-associated autoimmune disorders...
  3. ncbi CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter
    G W Beresford
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 2:652-7. 2001
    ..H4 acetylation was mapped to Lys8, which implicated several histone acetyltransferases as possible modulators of this activity...
  4. ncbi Genetic control of MHC class II expression
    Jenny Pan Yun Ting
    Department of Microbiology and Immunology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 109:S21-33. 2002
    ..The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression...
  5. ncbi MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci
    Unni Grimholt
    Department of Morphology, Genetics and Aquatic Biology, Section of Genetics, Norwegian School of Veterinary Science, Ullevaalsveien 72, P O Box 8146 Dep, 0033 Oslo, Norway
    Immunogenetics 55:210-9. 2003
    ..The observed associations were detected due to independently segregating MH class I and class II single loci, and inclusion of a large number of fish allowing an extensive statistical analysis...
  6. ncbi Clinal variation in MHC diversity with temperature: evidence for the role of host-pathogen interaction on local adaptation in Atlantic salmon
    Mélanie Dionne
    Departement de Biologie, Universite Laval, Quebec, G1K 7P4, Canada
    Evolution 61:2154-64. 2007
    ..This study illuminates the link between selection pressure from the environment, host immune adaptation, and the large-scale genetic population structure for a nonmodel vertebrate in the wild...
  7. ncbi The role of mhc polymorphism in anti-microbial resistance
    Janko Nikolich-Zugich
    Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center of the Oregon Health, Science University, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Microbes Infect 6:501-12. 2004
    ..Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility...
  8. ncbi Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
    C H Chang
    Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 4:167-78. 1996
    ..The transcription of nonconventional MHC class II genes is, however not affected by CIITA deficiency...
  9. ncbi Parasite burden and constitution of major histocompatibility complex in the Malagasy mouse lemur, Microcebus murinus
    J Schad
    Department of Animal Ecology and Conservation, University of Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Evolution 59:439-50. 2005
    ..murinus is maintained through pathogen-driven selection acting by frequency-dependent selection. This is the first study of the association of MHC variation and parasite burden in a free-ranging primate...
  10. ncbi Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics
    C Tollenaere
    INRA EFPA, UMR CBGP INRA IRD Cirad Montpellier SupAgro, Campus International de Baillarguet, Montferrier sur Lez CEDEX, France
    J Evol Biol 21:1307-20. 2008
    We investigated the factors mediating selection acting on two MHC class II genes (DQA and DRB) in water vole (Arvicola scherman) natural populations in the French Jura Mountains...
  11. ncbi Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex
    A J Jeffreys
    Department of Genetics, University of Leicester, Leicester, LE1 7RH, UK
    Nat Genet 29:217-22. 2001
    ..These data show that, within the MHC at least, crossovers are far from randomly distributed at the molecular level and that recombination hot spots can profoundly affect LD patterns...
  12. ncbi Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes
    Rene J M Stet
    Cell Biology and Immunology Group, Wageningen Institute of Animal Sciences, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    Immunogenetics 54:320-31. 2002
    ..In contrast to other studies of salmonid class II sequences, phylogenetic analyses of brown trout and Atlantic class II A and class II B sequences provided support for trans-species polymorphism...
  13. pmc RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency
    B Durand
    Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland
    EMBO J 16:1045-55. 1997
    ..Complementation of the 6.1.6 and DA cell lines by transfection with RFXAP fully restores expression of all endogenous MHC-II genes in vivo, demonstrating that RFXAP is a novel essential MHC-II regulatory gene...
  14. ncbi Diversity of Mhc class I and IIB genes in house sparrows (Passer domesticus)
    Camille Bonneaud
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7103, Universite Pierre et Marie Curie, Batiment A, 7e étage, 7 quai St Bernard, Case 237, 75252 Paris, Cedex 05, France
    Immunogenetics 55:855-65. 2004
    ..The individuals screened displayed between one and ten DGGE bands, indicating that this method can be used in future studies to explore the ecological impacts of Mhc diversity...
  15. pmc Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells
    Michaela Lucas
    Nuffield Department of Medicine, University of Oxford, United Kingdom
    J Virol 78:7284-7. 2004
    ..These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct "central memory" CD62L(+) phenotype...
  16. pmc Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial
    Hannah V Siddle
    Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia
    Proc Natl Acad Sci U S A 104:16221-6. 2007
    ..The neoplastic clone continues to spread although the population, and, without active disease control by removal of affected animals and the isolation of disease-free animals, the Tasmanian devil faces extinction...
  17. pmc Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression
    Eleni Zika
    Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:16321-6. 2005
    ..These results suggest functional and temporal relationships among CIITA, CARM1, and CBP for IFN-gamma induction of MHC-II...
  18. ncbi A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
    K Masternak
    Louis Jeantet Laboratory of Molecular Genetics, Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland
    Nat Genet 20:273-7. 1998
    ..RFXANK contains a protein-protein interaction region consisting of three ankyrin repeats. Its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters...
  19. ncbi Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes
    M A Shaw
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY
    Genes Immun 2:196-204. 2001
    ..Taken together the segregation and HLA analyses suggest the possibility of more than one susceptibility locus in the MHC...
  20. pmc Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A
    Manolis Gialitakis
    Institute of Molecular Biology and Biotechnology, FORTH, Heraklion 71110, Greece
    Nucleic Acids Res 34:765-72. 2006
    ..A complex pattern of gene reprogramming by TSA involves immune recognition, antiviral, apoptotic and inflammatory pathways and extends the rationale for using Histone Deacetylase Inhibitors (HDACi) to modulate the immune response...
  21. pmc Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
    A Muhlethaler-Mottet
    Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland
    EMBO J 16:2851-60. 1997
    ..This provides novel experimental tools to dissect compartment-specific gain or loss of MHC-II function in vivo...
  22. pmc Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation
    Eleni Zika
    Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 23:3091-102. 2003
    ....
  23. ncbi The bare lymphocyte syndrome and the regulation of MHC expression
    W Reith
    Jeantet Laboratory of Molecular Genetics, Department of Genetics and Microbiology, University of Geneva Medical School, 1 rue Michel Servet, Geneva 4, 1211 Switzerland
    Annu Rev Immunol 19:331-73. 2001
    ..The study of RFX and CIITA has made major contributions to our comprehension of the molecular mechanisms controlling MHCII genes and has made this system into a textbook model for the regulation of gene expression...
  24. ncbi Unprecedented polymorphism of Mhc-DRB region configurations in rhesus macaques
    G G Doxiadis
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Immunol 164:3193-9. 2000
    ..This approach will minimize as well the number of animals necessary to conduct experiments...
  25. ncbi Evidence that the separation of Mhc class II from class I loci in the zebrafish, Danio rerio, occurred by translocation
    Noriyuki Kuroda
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, 72076 Tubingen, Germany
    Immunogenetics 54:418-30. 2002
    ....
  26. ncbi Parasite selection for immunogenetic optimality
    K Mathias Wegner
    Max Planck Institute for Limnology, Department of Evolutionary Ecology, August Thienemann Str 2, 24306 Plön, Germany
    Science 301:1343. 2003
  27. ncbi Regulation of MHC class II gene expression by the class II transactivator
    Walter Reith
    Department of Pathology and Immunology, University of Geneva Medical School, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    Nat Rev Immunol 5:793-806. 2005
    ....
  28. ncbi Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo
    Marc A Gavin
    Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 3:33-41. 2002
    ..DNA array analyses identified genes that may inhibit responsiveness at a number of levels in multiple signaling cascades in T(S) cells, as well as several anti-apoptotic genes that may mediate their survival...
  29. ncbi Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways
    Eleni Tzortzakaki
    Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Heraklion 71110, Crete, Greece
    Mol Endocrinol 17:2509-18. 2003
    We show here that steroid receptor coactivator 1 (SRC-1) is a coactivator of MHC class II genes that stimulates their interferon gamma (IFNgamma) and class II transactivator (CIITA)-mediated expression...
  30. ncbi Class II HLA alleles and hepatitis B virus persistence in African Americans
    C L Thio
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 179:1004-6. 1999
    ..These results underscore the importance of the class II-mediated immune response in recovery from HBV infection...
  31. ncbi Gene conversion of major histocompatibility complex genes is associated with CpG-rich regions
    K Högstrand
    Division of Toxicology, Institute of Environmental Medicine, Karolinska Institute, Box 210, S 171 77 Stockholm, Sweden
    Immunogenetics 49:446-55. 1999
    ..Accordingly, the CpG dimers appear to be non-methylated in germline DNA from the testis of prepubescent mice, where gene conversions have been reported to occur...
  32. ncbi An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections
    Malak Kotb
    Veterans Affairs Medical Center, Research Service, Memphis, Tennessee, USA
    Nat Med 8:1398-404. 2002
    ..We propose that human leukocyte antigen class II allelic variation contributes to differences in severity of invasive streptococcal infections through their ability to regulate cytokine responses triggered by streptococcal superantigens...
  33. pmc A mechanism for the major histocompatibility complex-linked resistance to autoimmunity
    D Schmidt
    Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, Health Sciences Centre, The University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Exp Med 186:1059-75. 1997
    ..These results provide an explanation as to how protective MHC class II genes carried on one haplotype can override the genetic susceptibility to an autoimmune disease provided by ..
  34. ncbi Modes of salmonid MHC class I and II evolution differ from the primate paradigm
    B P Shum
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 166:3297-308. 2001
    ..A prevalent mechanism for evolving new MHC class I alleles in salmonids is recombination in intron II that shuffles alpha 1 and alpha 2 domains into different combinations...
  35. ncbi Retroviral transfer of donor MHC class I or MHC class II genes into recipient bone marrow cells can induce operational tolerance to alloantigens in vivo
    Wilson Wong
    Department of Nephrology and Transplantation, Guy s Hospital, London SE1 9RT, United Kingdom
    Hum Gene Ther 14:577-90. 2003
    ..These results have important implications for future strategies to enhance clinical allograft survival by delivery of donor alloantigens...
  36. ncbi Regulation of MHC class II genes: lessons from a disease
    B Mach
    Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland
    Annu Rev Immunol 14:301-31. 1996
    ..Finally, the facts that CIITA and RFX5 are both essential and highly specific for MHC-II genes make possible novel strategies designed to achieve immunomodulation via transcriptional intervention...
  37. ncbi Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome
    Nada Nekrep
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Nat Immunol 3:1075-81. 2002
    ..Its wild-type counterpart restored binding of the RFX complex to DNA, transcription of all MHC class II genes and the appearance of these determinants on the surface of BLS cells.
  38. ncbi Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A region molecules
    G Y Liu
    Cambridge University Department of Pathology, UK
    Immunogenetics 37:296-300. 1993
  39. ncbi The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders
    E Carrasco-Marin
    Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 156:450-8. 1996
    ..We hypothesize that the weak and unstable peptide-binding property of I-Ag7 molecules does not favor the elimination or inactivation of autoreactive T cells...
  40. ncbi Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice
    S J Rozzo
    Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 162:2623-30. 1999
    ..Taken together with our previous Ez studies, the present work calls into question the importance of class II MHC genes for lupus susceptibility in this model and provides new insight into the role of MHC in lupus-like autoimmunity...
  41. ncbi Sequence organisation of the class II region of the human MHC
    S Beck
    Sanger Centre, Cambridge, UK
    Immunol Rev 167:201-10. 1999
    ....
  42. ncbi The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA
    Annick Muhlethaler-Mottet
    University of Geneva Medical School, Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    J Biol Chem 279:40529-35. 2004
    ..module consisting of four cis-acting elements, the W, X, X2 and Y boxes, controls transcription of MHC class II genes. The X, X2, and Y boxes are bound, respectively, by RFX, CREB, and NF-Y to form a MHC class II-specific ..
  43. ncbi Comparative genetics of MHC polymorphisms in different primate species: duplications and deletions
    Ronald E Bontrop
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, GH Rijswijk, The Netherlands
    Hum Immunol 67:388-97. 2006
    ..The human HLA system represents the most thoroughly investigated MHC of any contemporary living primate species, and so it will serve as a reference...
  44. pmc Kinetics of a gamma interferon response: expression and assembly of CIITA promoter IV and inhibition by methylation
    Ann C Morris
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cell Biol 22:4781-91. 2002
    ..Together, this analysis provides a kinetic view of the activation of the CIITA gene in response to IFN-gamma and shows that regulatory factor assembly, chromatin modification, and gene expression proceed in discrete steps...
  45. ncbi Regulation of transcription of MHC class II genes
    J M Boss
    Department of Microbiology and Immunology, Emory University School of Medicine, 3131 Rollins Research Center, Atlanta, GA 30322, USA
    Curr Opin Immunol 9:107-13. 1997
    ..analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1...
  46. ncbi Single locus typing of MHC class I and class II B loci in a population of red jungle fowl
    K Worley
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, England
    Immunogenetics 60:233-47. 2008
    ..This is the first time that a population of red jungle fowl has been typed at the MHC region, laying the basis for further research into the underlying processes acting to maintain MHC diversity in this and other species...
  47. pmc MHC adaptive divergence between closely related and sympatric African cichlids
    Jonatan Blais
    Departement de Biologie, Québec Océan, Universite Laval, Quebec, Quebec, Canada
    PLoS ONE 2:e734. 2007
    ..We tested the hypothesis that these species have undergone divergent selection at MHC class II genes, which are known to contribute to olfactory-based mate choice in other taxa.
  48. pmc A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach
    Peng Wang
    La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS Comput Biol 4:e1000048. 2008
    ..We show that this consensus approach achieved best overall performance. Finally, we make the large datasets used publicly available as a benchmark to facilitate further development of MHC class II binding peptide prediction methods...
  49. pmc Comprehensive analysis of class I and class II HLA antigens and chronic hepatitis B virus infection
    Chloe L Thio
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Virol 77:12083-7. 2003
    ..The associations with class I alleles are consistent with a previously implicated role for CD8-mediated cytolytic-T-cell response in determining the outcome of an acute HBV infection...
  50. ncbi Differential evolutionary MHC class II strategies in humans and rhesus macaques: relevance for biomedical studies
    G G Doxiadis
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunol Rev 183:76-85. 2001
    ..Thus, both species used different evolutionary strategies to create polymorphism and diversity at the MHC class II loci in order to cope with pathogens...
  51. ncbi Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
    V Steimle
    Jeantet Laboratory of Molecular Genetics, Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland
    Cell 75:135-46. 1993
    ..It is due to a defect in the regulation of MHC class II genes. A novel gene was isolated by complementation cloning, using an MHC class II-negative mutant cell line...
  52. pmc Transcription-coupled deposition of histone modifications during MHC class II gene activation
    Natalia Rybtsova
    Department of Pathology and Immunology, University of Geneva Medical School, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    Nucleic Acids Res 35:3431-41. 2007
    ..These results provide strong evidence that transcription elongation can play a decisive role in the deposition of histone modification patterns associated with inducible gene activation...
  53. ncbi Genomic sequence of the class II region of the canine MHC: comparison with the MHC of other mammalian species
    Sally L Debenham
    Genetics Section, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    Genomics 85:48-59. 2005
    ..Elucidation of functionally important dog class II genes and the identification of 23 microsatellite markers spanning this region will contribute significantly to the study of canine diseases that have an immune component...
  54. ncbi Physical and genetic mapping of the rainbow trout major histocompatibility regions: evidence for duplication of the class I region
    Ruth B Phillips
    School of Biological Sciences, Washington State University, 14204 N E Salmon Creek Ave, Vancouver, WA 98686 9600, USA
    Immunogenetics 55:561-9. 2003
    ..Our data demonstrate that the trout MH regions are located on at least four different chromosomes and the corresponding linkage groups, while also providing direct evidence for the partial duplication of the MH class I region in trout...
  55. ncbi Class II multiformity generated by variable MHC- DRB region configurations in the California sea lion ( Zalophus californianus)
    Lizabeth Bowen
    Laboratory for Marine Mammal Immunology, School of Veterinary Medicine, Department of Pathology, Microbiology and Immunology, University of California, Davis, CA 95616, USA
    Immunogenetics 56:12-27. 2004
    ....
  56. ncbi Modulation of gene expression by the MHC class II transactivator
    Uma M Nagarajan
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 169:5078-88. 2002
    ..Of note was the identification of a set of genes localized to chromosome 1p34-35. The global modulation of genes in a local region suggests that this region may share some regulatory control with the MHC...
  57. ncbi Extensive Mhc-DQB variation in humans and non-human primate species
    Nel Otting
    Biomedical Primate Research Centre, Department of Immunobiology, Lange Kleiweg 139, 2280 GH Rijswijk, The Netherlands
    Immunogenetics 54:230-9. 2002
    ..In this study the emphasis was on MHC class II genes of another macaque species, Macaca fascicularis(crab eating macaque or cynomolgous monkey)...
  58. pmc The class II transactivator requires brahma-related gene 1 to activate transcription of major histocompatibility complex class II genes
    Rajini Mudhasani
    Department of Biological, Geological and Environmental Sciences, Cleveland State University, 2399 Euclid Avenue, Cleveland, OH 44115, USA
    Mol Cell Biol 22:5019-26. 2002
    ..When introduced into a cell line lacking BRG-1, CIITA was unable to activate cellular MHC class II genes. Reexpression of the wild-type but not an ATP-binding-deficient BRG-1 protein in this cell line restored the ..
  59. pmc Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes
    C Spilianakis
    Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology, Heraklion, Crete, Greece
    Mol Cell Biol 20:8489-98. 2000
    ..These results support a novel function for acetylation, i.e., to regulate gene expression by stimulating the nuclear accumulation of an activator...
  60. ncbi Identification and sequence analysis of an Mhc class II B gene in a marsupial (Monodelphis domestica)
    W H Stone
    Department of Biology, Trinity University, San Antonio, TX 78212 7200, USA
    Immunogenetics 49:461-3. 1999
  61. ncbi Balancing selection, random genetic drift, and genetic variation at the major histocompatibility complex in two wild populations of guppies (Poecilia reticulata)
    Cock van Oosterhout
    School of Biological Sciences, University of Hull, Hull HU6 7RX, United Kingdom
    Evolution 60:2562-74. 2006
    ..Selection by parasites plays a particularly important role in the evolution of guppies in the upland habitat, which has resulted in high levels of MHC diversity being maintained in this population despite considerable genetic drift...
  62. ncbi Recombination and the origin of sequence diversity in the DRB MHC class II locus in chamois (Rupicapra spp.)
    Helmut Schaschl
    Institute of Zoology, Zoological Society of London, Regent s Park, London, NW1 4RY, UK
    Immunogenetics 57:108-15. 2005
    ..Recombination coupled with positive selection drives the rapid evolution at the peptide-binding sites in the MHC class II DRB gene. Many chamois MHC class II DRB alleles are thus much younger than previously assumed...
  63. ncbi Major histocompatibility complex variation in the Arabian oryx
    P W Hedrick
    Department of Biology, Arizona State University, Tempe 95287, USA
    Evolution 54:2145-51. 2000
    ..As a result, maintenance of these variants should be considered as a goal in the captive breeding program of the Arabian oryx...
  64. ncbi Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes
    Eleni Zika
    Lineberger Comprehensive Cancer Center, CB 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Opin Immunol 17:58-64. 2005
    ..MHC-II expression is exquisitely controlled by these highly specific, coordinated and dynamic interactions at the promoter...
  65. ncbi Long distance control of MHC class II expression by multiple distal enhancers regulated by regulatory factor X complex and CIITA
    Michal Krawczyk
    University of Geneva Medical School, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneva, Switzerland
    J Immunol 173:6200-10. 2004
    ..These results reveal a hitherto unexpected level of complexity involving long distance control of MHC-II expression by multiple distal regulatory elements...
  66. ncbi A third broad lineage of major histocompatibility complex (MHC) class I in teleost fish; MHC class II linkage and processed genes
    Johannes Martinus Dijkstra
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Immunogenetics 59:305-21. 2007
    ..The present study significantly improves the knowledge of MHC class I variation in teleosts...
  67. ncbi Characterization of polymorphism within the H2-M MHC class II loci
    E Hermel
    Department of Molecular Genetics, University of Cincinnati, OH 45267 0524, USA
    Immunogenetics 42:136-42. 1995
    ..When modeled on the crystal structure of the HLA-DR1 class II molecule, nearly all of the differences between M beta 1 and M beta 2 affect residues facing away from the putative peptide binding groove...
  68. ncbi Epigenetic regulation of MHC-II and CIITA genes
    Kenneth L Wright
    H Lee Moffitt Cancer Center and Research Institute, and the Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
    Trends Immunol 27:405-12. 2006
    ..Finally, the relevance of these findings to infection, transplantation and cancer will be reviewed...
  69. ncbi Recent duplication and inter-locus gene conversion in major histocompatibility class II genes in a teleost, the three-spined stickleback
    Thorsten B H Reusch
    Max Planck Institut für Limnologie, August Thienemann Strasse 2, 24306 Plön, Germany
    Immunogenetics 56:427-37. 2004
    ..007). In accordance, we found a 10- to 20-fold higher frequency of CpG-islands on the MH class II segment compared to other species, a feature that may be conducive for inter-locus recombination...
  70. ncbi Application of machine learning techniques in predicting MHC binders
    Sneh Lata
    Institute of Microbial Technology, Chandigarh, India
    Methods Mol Biol 409:201-15. 2007
    ..ANNPred allows prediction of binders for only 30 alleles purely based on the ANN. MHC2Pred is a support vector machine (SVM)-based method for prediction of promiscuous binders for 42 MHC class II alleles...
  71. ncbi Marsupial MHC class II beta genes are not orthologous to the eutherian beta gene families
    K Belov
    Evolutionary Biology Unit, Australian Museum, 6 College St, Sydney, NSW 2010, Australia
    J Hered 95:338-45. 2004
    ..DAB and DBB orthologs are not present in eutherians. It appears that the marsupial and eutherian lineages have retained different gene clusters following gene duplication events early in mammalian evolution...
  72. ncbi Genotypic characterization of an MHC class II locus in lake trout ( Salvelinus namaycush) from Lake Superior by single-stranded conformational polymorphism analysis and reference strand-mediated conformational analysis
    Marc A Noakes
    Washington State University, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686, USA
    Mar Biotechnol (NY) 5:270-8. 2003
    ..SSCP analysis was quicker, simple, and more robust than RSCA. SSCP analysis using fluorescence technologies could be the method of choice for future genotypic analysis of the MHC II locus in salmonids...
  73. ncbi Genetic variation in MHC class II expression and interactions with MHC sequence polymorphism in three-spined sticklebacks
    K M Wegner
    Max Planck Institute of Limnology, Department of Evolutionary Ecology, August Thienemann Str 2, 24306 Plön, Germany
    Mol Ecol 15:1153-64. 2006
    ..The observed differences among families and the negative correlation with individual sequence diversity imply that MHC expression is evolutionary relevant for the onset and control of the immune response in natural populations...
  74. ncbi Characterization of MHC class II genes from an ancient reptile lineage, Sphenodon (tuatara)
    Hilary C Miller
    Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological Sciences, Victoria University of Wellington, New Zealand
    Immunogenetics 57:883-91. 2005
    ..The tuatara sequences do not strongly group with other reptile sequences on a phylogenetic tree, reflecting the antiquity of the Sphenodon lineage and the lack of closely related sequences for comparison...
  75. ncbi Epigenetic silencing of MHC2TA transcription in cancer
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biochem Pharmacol 72:1570-6. 2006
    ..Here we discuss our current knowledge on the expression characteristics of MHC2TA and argue for an important role of epigenetic factors and mechanisms in the transcriptional silencing of MHC2TA in cancer cells...
  76. ncbi Prediction of MHC-binding peptides of flexible lengths from sequence-derived structural and physicochemical properties
    J Cui
    Bioinformatics and Drug Design Group, Department of Pharmacy and Department of Computational Science, National University of Singapore, Singapore 117543, Republic of Singapore
    Mol Immunol 44:866-77. 2007
    ..01-5% for 24 and 5-8% for 6 alleles) of its constituent peptides are predicted as binders. Our software can be accessed at ...
  77. ncbi Conservation of MHC class II DOA sequences among carnivores
    S J Soll
    Department of Chemistry, Portland State University, Portland, OR 97207, USA
    Tissue Antigens 65:283-6. 2005
    ..A seven-amino-acid motif of VWRLPEF was found to be conserved across all DOA sequences and may be a DO-specific recognition element...
  78. ncbi Mhc-DRB genes evolution in lemurs
    Yasuhiro Go
    Primate Research Institute, Kyoto University, Inuyama, Aichi 484 8506, Japan
    Immunogenetics 54:403-17. 2002
    ..These observations correspond with the postulation that a severe bottleneck occurred when the ancestors of lemurs settled into Madagascar from the African continent...
  79. pmc Mortality selection during the 2003 European heat wave in three-spined sticklebacks: effects of parasites and MHC genotype
    K Mathias Wegner
    Department of Integrative Biology IBZ, Experimental Ecology, ETH Zurich, Universitatstrasse 16, CH 8092 Zurich, Switzerland
    BMC Evol Biol 8:124. 2008
    ....
  80. ncbi The MHC and non-random mating in a captive population of Chinook salmon
    B D Neff
    Department of Biology, University of Western Ontario, London, Ontario, Canada
    Heredity (Edinb) 101:175-85. 2008
    ..These results indicate that sexual selection favours increased body size and perhaps integument coloration in males as well as increases genetic diversity at the MHC by female mate choice...
  81. ncbi High levels of diversity characterize mandrill (Mandrillus sphinx) Mhc-DRB sequences
    Kristin M Abbott
    PRIME, Department of Biological Anthropology, University of Cambridge, Downing Street, Cambridge, CB2 3DZ, UK
    Immunogenetics 58:628-40. 2006
    ..As observed in other primates, some new lineages may have arisen through the process of gene conversion. These findings indicate that mandrills have Mhc-DRB diversity not unlike rhesus macaques and humans...
  82. pmc Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes
    Michal Krawczyk
    Department of Pathology and Immunology, University of Geneva Medical School, CMU, 1 rue Michel Servet, CH 1211 Geneva, Switzerland
    Nucleic Acids Res 35:595-605. 2007
    ..is thus activated by the same regulatory machinery that is known to be essential for the expression of MHC class II genes. This molecular link between the transcriptional activation of RAB4B and MHC class II genes implies that APC ..
  83. ncbi Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif
    Yuerong Zhu
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 326:1157-74. 2003
    ..In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix...
  84. ncbi Rheumatic fever: from sore throat to autoimmune heart lesions
    Luiza Guilherme
    Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Int Arch Allergy Immunol 134:56-64. 2004
    ..These results illustrate the complex mechanisms leading to heart tissue damage in RF/RHD patients...
  85. ncbi Ozone exposure enhances antigen-presenting activity of interstitial lung cells in rats
    Eiko Koike
    Particulate Matter and Diesel Exhaust Project, National Institute for Environmental Studies, Onogawa 16 2, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 196:217-27. 2004
    ..The increase in the AP activity might contribute to subsequent antibody production, airway hyperresponsiveness and aggravation of allergic responses...
  86. ncbi Transcriptional regulation of antigen presentation
    Peter J van den Elsen
    Department of Immunohematology and Blood Transfusion, Building 1, E3 Q, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Curr Opin Immunol 16:67-75. 2004
    ..Accordingly, recent studies include investigations into chromatin remodeling and epigenetic control mechanisms that modulate cell-type-specific transcriptional regulation of genes involved in antigen presentation...
  87. ncbi Evolution of MHC-DRB class II polymorphism in the genus Apodemus and a comparison of DRB sequences within the family Muridae (Mammalia: Rodentia)
    Kerstin Musolf
    Department of Animal Ecology and Conservation, Biozentrum Grindel, University of Hamburg, Martin Luther King Platz 3, 20146 Hamburg, Germany
    Immunogenetics 56:420-6. 2004
    ..Phylogenetic analysis, including additional murid taxa, showed that the DRB exon 2 sequences did not separate according to species, consistent with trans-species evolution of the MHC in these taxa...
  88. pmc HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia
    Valda Stanevicha
    Department of Pediatrics, Riga Stradins University, Riga, Latvia
    Arthritis Res Ther 5:R340-6. 2003
    ..In Sydenham's chorea patients, the DQB1*0401-2 allele was more frequent. Genotyping control showed a high risk of RF and RHD in patients with DRB1*01-DQB1*0301-DRB1*07-DQB1*0302 and DRB1*15-DQB1*0302-DRB1*07-DQB1*0303...
  89. ncbi MHC diversity and the association to nematode parasitism in the yellow-necked mouse (Apodemus flavicollis)
    Y Meyer-Lucht
    Department Animal Ecology and Conservation, Biozentrum Grindel, University of Hamburg, Martin Luther King Platz 3, D 20146 Hamburg, Germany
    Mol Ecol 14:2233-43. 2005
    ..In contrast, the allele Apfl-DRB*23 showed a significant association to low FEC of the most common nematode. Thus, our results provide evidence for pathogen-driven selection acting through rare allele advantage under natural conditions...
  90. pmc Comparative genome organization of human, murine, and feline MHC class II region
    Naoya Yuhki
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Genome Res 13:1169-79. 2003
    ..Comparison of the feline MHC with the murine and human MHC offers a detailed view of the consequences of genome organization in three mammalian lineages...
  91. ncbi Duplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae)
    J Bryja
    Centre de Biologie et Gestion des Populations UMR 22, INRA, Campus International de Baillarguet, CS 30016, 34988 Montferrier sur Lez, Cedex, France
    Immunogenetics 58:191-202. 2006
    ..We discuss possible role of parasites in forming the recent polymorphism pattern of the DQA locus in voles...
  92. ncbi Extensive sharing of MHC class II alleles between rhesus and cynomolgus macaques
    Gaby G M Doxiadis
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunogenetics 58:259-68. 2006
    ..Despite extensive allele sharing, rhesus and cynomolgus monkeys do not appear to possess identical Mhc class II haplotypes, thus illustrating that new haplotypes were generated after speciation by recombination-like processes...
  93. ncbi Chromatin remodeling and extragenic transcription at the MHC class II locus control region
    Krzysztof Masternak
    University of Geneva Medical School, CMU, Switzerland
    Nat Immunol 4:132-7. 2003
    ..The finding that RFX and CIITA regulate the function of the MHC class II LCR reveals an unexpected degree of complexity in the mechanisms controlling MHC class II gene expression...
  94. ncbi MHC class II beta sequence diversity in the deer mouse (Peromyscus maniculatus): implications for models of balancing selection
    A D Richman
    Plant Sciences Department, MSU Bozeman, Bozeman, MT 59719, USA, Department of Zoology, Universidad Nacional Autonoma de Mexico, Instituto de Biologia, Mexico, Mexico
    Mol Ecol 10:2765-73. 2001
    ..maniculatus together provide support for a divergent allele advantage model for the maintenance of MHC polymorphism...
  95. ncbi A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production
    T Gourley
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109, USA
    Immunity 10:377-86. 1999
    ..Thus, in addition to its role in transactivation of genes involved in antigen presentation, CIITA plays a critical role during the T cell differentiation by negatively regulating the IL-4 gene transcription...
  96. pmc Ancestral polymorphism of Mhc class II genes in mice: implications for balancing selection and the mammalian molecular clock
    S V Edwards
    Department of Zoology, University of Washington, Seattle 98195, USA
    Genetics 146:655-68. 1997
    ..Thus rates of synonymous substitution at Mhc DR genes in mammals appear to be subject to generation time effects in ways similar to those found at other mammalian genes...
  97. ncbi Physical assignment of the bovine MHC class IIa and class IIb genes
    M Hess
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Cytogenet Cell Genet 85:244-7. 1999
    ..These two different mapping locations confirm and extend previous findings of a gross physical distance between classic and non-classic MHC class II genes in cattle.
  98. ncbi A conditional null allele of the major histocompatibility IA-beta chain gene
    Kahoko Hashimoto
    Institute of Molecular Medicine and Genetics and Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Genesis 32:152-3. 2002
  99. ncbi Locus specificity of polymorphic alleles and evolution by a birth-and-death process in mammalian MHC genes
    X Gu
    Institute of Molecular Evolutionary Genetics, Pennsylvania State University, USA
    Mol Biol Evol 16:147-56. 1999
    ....
  100. pmc A determination of the frequency of gene conversion in unmanipulated mouse sperm
    K Högstrand
    Department of Immunology, Wenner Gren Institute, University of Stockholm, Sweden
    Proc Natl Acad Sci U S A 91:9921-5. 1994
    ..Fragments > 100 bp seem to be possible to transfer in this conversion...
  101. ncbi Different distribution of HLA class II alleles in anti-topoisomerase I autoantibody responders between silicosis and systemic sclerosis patients, with a common distinct amino acid sequence in the HLA-DQB1 domain
    A Ueki
    Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan
    Immunobiology 204:458-65. 2001
    ..The above-mentioned amino acid sequence is detected in alleles *0301, *0303, *0306, *0401, *0402, *0601 and *0602...

Research Grants62

  1. Regulation of MHC Class II Genes
    Jeremy M Boss; Fiscal Year: 2013
    ..Understanding the molecular bases for how these genes are regulated will serve to predict targets and pathways that could be manipulated in clinical settings to treat the above diseases. ..
  2. MHC Class II Transactivator Function and Regulation
    JEREMY BOSS; Fiscal Year: 2009
    The appropriate and normal regulation of MHC class II genes is central to a healthy and active immune system and critical for our ability to combat pathogens...
  3. Testing mechanisms of parasite-mediated selection on MHC genetic diversity
    JILLIAN TIKKA DETWILER; Fiscal Year: 2013
    ..Aim 2 will test the hypothesis that contemporary selection is acting on MHC class II genes. This will be one of the first studies to test for selection on MHC genes in a widely distributed and ..
  4. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..The mechanisms by which MHC class II genes confer susceptibility to this antibody-mediated autoimmune disease will be studied in a DQ1 transgenic mouse ..
  5. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001
    ..from Investigator's abstract): This application is focused on characterizing the role of HLA-DR1 and HLA-DR4 MHC class II genes in the development of autoimmune responses to human type II collagen (hCII)...
  6. ISOLATION OF CDNA'S FOR HLA CLASS II TRANSACTING FACTORS
    Benjamin Schwartz; Fiscal Year: 1992
    ..The binding proteins will be characterized, and the genomic genes cloned. These experiments should elucidate the mechanism by which proteins binding to the regulatory region of class II genes play a role in class II expression...
  7. IMMUNOBIOLOGY OF MHC CLASS II TRANSACTIVATOR
    Cheong Hee Chang; Fiscal Year: 2001
    ..on the MHC class II trans-activator (CIITA), a transcriptional factor required for the transcription of MHC class II genes. We and others have shown that CIITA is essential for both constitutive and IFN-gamma inducible expression ..
  8. PEPTIDE EPITOPES PRESENTED IN AUTOIMMUNE DIABETES
    Samuel Wilson; Fiscal Year: 1999
    ..The candidate plans to use this system as a generalized model for antigen processing and presentation. ..
  9. STRUCTURAL BASIS OF FUNCTIONAL CLASS II GENE EXPRESSION
    Laurie Glimcher; Fiscal Year: 2001
    ....
  10. STRUCTURAL BASIS OF FUNCTIONAL CLASS II GENE EXPRESSION
    Laurie Glimcher; Fiscal Year: 1992
    ....
  11. MHC Class II Bare Lymphocyte Syndrome factors
    JEREMY BOSS; Fiscal Year: 2003
    ..b>MHC class II genes are regulated by four transcription factors whose genes are deficient in a rare, genetic-based ..
  12. Chromatin remodeling and MHC class II gene transcription
    JOSEPH FONTES; Fiscal Year: 2003
    ..are two chromatin "barriers"--one on the promoters and the second on the protein coding regions--present on MHC class II genes. The first specific aim will employ restriction endonuclease accessibility and micrococcal nuclease assay to ..
  13. Tcell tolerization in the treatment of Type I diabetes
    Boris Nikolic; Fiscal Year: 2006
    ..induced by autologous bone marrow cells which have been retrovirally-transduced with diabetes protective MHC class II genes, is sufficient to tolerize diabetogenic T cells...
  14. MOLECULAR APPROACHES TO IA GENE FUNCTION AND REGULATION
    Georg Widera; Fiscal Year: 1993
    The I region of the MHC encodes the Ia antigens or MHC class II genes. These proteins are necessary for recognition of foreign antigen on antigen presenting cells and on B cells by helper T cells in the periphery and they select the H-2 ..
  15. Prevention of IDDM by Expression of a Modified I-Ag7
    Daniel Kaufman; Fiscal Year: 2002
    ..Both the human and murine IDDM-associated MHC class II genes contain two unique amino acid polymorphisms at codons beta-56 and beta-57...
  16. MHC CLASS II MOLECULES AND TYPE I IDDM
    Hugh McDevitt; Fiscal Year: 1999
    ..Investigator's abstract): The overall objective of this research application is to understand the role of MHC class II genes in susceptibility and resistance to IDD in the NOD mouse...
  17. CONTACT DEPENDENT ENDOTHELIAL ACTIVATION BY NK CELLS
    Jeffrey Bender; Fiscal Year: 2003
    ..integrin-ICAM adhesion-dependent fashion, human CD56+, CD3- NK cells efficiently induce activation of EC MHC class II genes. Despite involvement of the transcription factor STAT1, neither IFN-gamma, the class II transactivator (..
  18. Role of MHC & non-MHC genes in the treatment of diabetes
    Boris Nikolic; Fiscal Year: 2004
    ..induced by autologous bone marrow cells, which have been retrovirally-transduced with diabetes protective MHC class II genes, is sufficient to prevent diabetes...
  19. Autoimmune Mechanisms in the Progression of CVD in Type 1 Diabetes
    Myra Lipes; Fiscal Year: 2009
    ..effector mechanisms in PIA and assess whether susceptibility to PIA is controlled by diabetes-associated MHC class II genes;and 3) To define the mechanisms underlying the initiation of PIA...
  20. Regulators and Regulation of MHC class II genes
    JOSEPH FONTES; Fiscal Year: 2009
    ..In the specific aim 2, a new transcriptional regulatory protein for MHC class II genes will be characterized...
  21. MHC LINKED SUSCEPTIBILITY TO AUTOIMMUNITY--STRUCTURE
    Don Wiley; Fiscal Year: 1999
    ..Human MHC class II genes encoding the chains of HLA-DQ8 (DQB1*0302) and DQ2 (DQB1*0201) are high risk alleles...
  22. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  23. M Tuberculosis and Host-Defense Mechanisms
    Jenny Ting; Fiscal Year: 2009
    ..Crucial experiments will be reproduced with MDR TB. If ASC alters host response to Mtb, future experiments will be planned to study an ASC-null mouse. ..
  24. Innate Immune Response Genes and P. Gingivalis
    Jenny Ting; Fiscal Year: 2009
    ..4) Cell lines with reduced ASC will also be tested. Since ASC can overcome the negative regulatory function of Monarch-1 and CIAS, ASC may enhance immune response to Pg to contain the infection. ..
  25. The vital role of BAFF in the development of SLE
    William Stohl; Fiscal Year: 2010
    ..abstract_text> ..
  26. Role of CIITA Isoforms in Graft Rejection
    Jenny Ting; Fiscal Year: 2006
    ..3) What are the biochemical and biophysical natures of these three isoforms? Can this information assist us in the design of small peptides that may block the function of CIITA, and therefore enhance the survival of allogeneic grafts?..
  27. Plexin-A1: Regulation by CIITA and immunologic function
    Jenny Ting; Fiscal Year: 2007
    ..abstract_text> ..
  28. Role of Class II MHC Antigens in Neurologic Diseases
    Jenny Ting; Fiscal Year: 2005
    ..4. Identify genes that are activated upon class II MHC engagement. in a microglial-macrophage line by Affy metrix screening, and assess the status of these genes in the cuprizone model. ..
  29. MOLECULAR REGULATION OF CLASS II MHC GENES
    Jenny Ting; Fiscal Year: 2001
    ..These goals will further our comprehension of class II gene regulation at the molecular and biologic levels. ..
  30. Q-TOF Mass Spectrometer
    JEREMY BOSS; Fiscal Year: 2002
    ..This state-of-the-art instrument?s flexibility, sensitivity, and accuracy will increase greatly the productivity of the research projects described as well as other NIH projects at Emory. ..
  31. Cordinate Control of Human HLA-D Region and II Genes
    Jenny Ting; Fiscal Year: 2005
    ..abstract_text> ..
  32. MHC Loci in the Control of Marek's Lymphoma
    MARCIA MILLER; Fiscal Year: 2005
    ..abstract_text> ..
  33. Immunogenetic characterization of MHC molecules as a tool for biomedical research
    Alessandro Sette; Fiscal Year: 2007
    ..These experiments will validate the approach and tools developed and also identify epitopes that can be utilized to monitor responses in these A-C pathogen systems. [unreadable]..
  34. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  35. Tumor cell antigen presentation to CD4 + T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2004
    ..of anti-tumor immunity? Which effector cells, cytokines, and chemokines are induced during therapy? 5) Does tumor burden correlate with tumor-induced immuno-suppression? Does surgical removal of primary tumor reverse mmuno-suppression? ..
  36. ROLE OF CATHEPSINS S, L AND B IN THE TYPE 1 DIABETES
    Alexander Rudensky; Fiscal Year: 2003
    ..This work will contribute to our understanding of the role of cathepsins in MHC class II antigen presentation, and provide new targets for downmodulating the immune responses leading to Type 1 diabetes. ..
  37. Requirements for regulatory T cell development
    MICHELE KOSIEWICZ; Fiscal Year: 2003
    ..These experiments may determine the requirements for regulatory T cell development, and thereby, identify pathways that can be therapeutically manipulated to prevent and/or treat autoimmune diseases. ..
  38. METHODS FOR FUNCTIONAL/COMPARATIVE GENOMICS
    Xun Gu; Fiscal Year: 2003
    ..abstract_text> ..
  39. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  40. CLASS II MHC TRANSPORT AND FUNCTION
    Clifford V Harding; Fiscal Year: 2010
    ..Overall, these studies will enhance our understanding of tuberculosis pathogenesis and contribute to optimization of vaccine strategies for tuberculosis. ..
  41. MOLECULAR GERONTOLOGY OF THE HUMAN OLFACTORY SYSTEM
    MARILYN GETCHELL; Fiscal Year: 2002
    ..abstract_text> ..
  42. NOVEL MHC CLASS II CONSTRUCTS FOR TREATMENT OF EAE
    GREGORY GEORGE BURROWS; Fiscal Year: 2010
    ..Evaluation of the in vivo effects RTLs have on relapsing-remitting and chronic models of EAE. The work proposed will provide a solid base for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. ..
  43. Natural History of Prostatism: The Olmsted County Study
    JENNIFER LYNN ST SAUVER; Fiscal Year: 2010
    ....
  44. New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational Asthma
    ADAM WISNEWSKI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  45. SEQUENCE AND POLYMORPHISM OF RHESUS MACAQUE MHC
    Daniel Geraghty; Fiscal Year: 2007
    ..We will accomplish these aims in part by combining resources and expertise in macaque genetics,genomics, and function from three accomplished laboratories. ..
  46. IFN Immune Effector Mechanisms in Cerebral Toxoplasmosis
    SANDRA HALONEN; Fiscal Year: 2006
    ..abstract_text> ..
  47. HLA-E, F, G interactions & the immunology of pregnancy
    Daniel Geraghty; Fiscal Year: 2008
    ..We also propose to develop materials and reagents useful towards the further understanding of the structure, biochemistry, and function of HLA- E, F, and G. ..
  48. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2005
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  49. Antigen presentation to T cells in nonlymphoid tissue
    JAMES MCLACHLAN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  50. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
    ..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
  51. Mechanism of Actions of Multitasking of Statins in AD
    Inderjit Singh; Fiscal Year: 2006
    ..abstract_text> ..
  52. Mechanisms ot Maternal Immune Tolerence
    Laurie Glimcher; Fiscal Year: 2006
    ..abstract_text> ..
  53. Angiocidal Effect of Cyclosporine in Cancer Therapy
    Dilip Kittur; Fiscal Year: 2006
    ..Our studies have the potential of discovering a novel, angiocidal effect of a commonly used drug. If successful, these studies will be translated expeditiously into clinical trials for the treatment of cancer. ..
  54. Structure and Function of Class II MHC Proteins
    Lawrence Stern; Fiscal Year: 2006
    ..abstract_text> ..
  55. The Regulation and Function of CIITA in CD4 T Cells
    Cheong Hee Chang; Fiscal Year: 2005
    ..The results from these experiments will help us to unravel the complexity and the role of CIITA in the regulation of the IL-4 gene during T cell differentiation. ..
  56. IMMUNODERMATOLOGICAL THERAPY OF SKIN CANCER
    Craig Elmets; Fiscal Year: 2003
    ..The ultimate goal of this proposal is to generate new knowledge that can be used to develop new and better strategies for the control of non-melanoma and melanoma skin cancer. ..
  57. Physical Activity, Aging and Immune Function
    Jeffrey Woods; Fiscal Year: 2005
    ..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..
  58. Structure/Function of Peroxisomes in Neuroinflammation
    Inderjit Singh; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  59. Maternal Microchimerism in Renal Disease
    Anne Stevens; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  60. CHILDHOOD VACCINES AND DENTAL CARIES IMMUNITY
    Daniel Smith; Fiscal Year: 2007
    ..unreadable]..
  61. Latent and Reactivation Tuberculosis
    Joanne Flynn; Fiscal Year: 2007
    ..These studies are the first to study reactivation in an immunologically tractable animal model that is similar to human latent tuberculosis. ..
  62. Analyzing and modulating immunoregulatory defects in autoimmune disease.
    Michele M Kosiewicz; Fiscal Year: 2010
    ..abstract_text> ..