major histocompatibility complex

Summary

Summary: The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.

Top Publications

  1. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
  2. ncbi The evolutionary ecology of the major histocompatibility complex
    S B Piertney
    School of Biological Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, UK
    Heredity (Edinb) 96:7-21. 2006
  3. ncbi How TCRs bind MHCs, peptides, and coreceptors
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
    Annu Rev Immunol 24:419-66. 2006
  4. ncbi A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    Y Imai
    Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan
    Biochem Biophys Res Commun 224:855-62. 1996
  5. ncbi The chicken B locus is a minimal essential major histocompatibility complex
    J Kaufman
    Institute for Animal Health, Compton, UK
    Nature 401:923-5. 1999
  6. ncbi SYFPEITHI: database for MHC ligands and peptide motifs
    H Rammensee
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Immunogenetics 50:213-9. 1999
  7. ncbi Natural selection at major histocompatibility complex loci of vertebrates
    A L Hughes
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Annu Rev Genet 32:415-35. 1998
  8. pmc Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations
    Christophe Eizaguirre
    Leibniz Institute for Marine Sciences, Department of Evolutionary Ecology of Marine Fishes, Duesternbrooker Weg 20, 24105 Kiel, Germany
    Nat Commun 3:621. 2012
  9. pmc Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species
    Natasja G de Groot
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunogenetics 64:615-31. 2012
  10. pmc Interrogating the major histocompatibility complex with high-throughput genomics
    Paul I W de Bakker
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 21:R29-36. 2012

Research Grants

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  2. Tibor T Glant; Fiscal Year: 2016
  3. Tibor T Glant; Fiscal Year: 2014
  4. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
  5. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
  6. Matthew B Grisham; Fiscal Year: 2015
  7. Laurence J N Cooper; Fiscal Year: 2014
  8. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
  9. Jay Reddy; Fiscal Year: 2016
  10. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012

Detail Information

Publications448 found, 100 shown here

  1. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  2. ncbi The evolutionary ecology of the major histocompatibility complex
    S B Piertney
    School of Biological Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, UK
    Heredity (Edinb) 96:7-21. 2006
    The major histocompatibility complex (MHC) has become a paradigm for how selection can act to maintain adaptively important genetic diversity in natural populations...
  3. ncbi How TCRs bind MHCs, peptides, and coreceptors
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
    Annu Rev Immunol 24:419-66. 2006
    ..Notwithstanding, the impressive array of self, foreign (microbial), and autoimmune TCR complexes have uncovered the diverse ways in which antigens can be specifically recognized by TCRs...
  4. ncbi A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    Y Imai
    Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan
    Biochem Biophys Res Commun 224:855-62. 1996
    ..The genomic copy of the iba1 gene was located within a segment of the major histocompatibility complex class III region between the Bat2 and TNF alpha genes...
  5. ncbi The chicken B locus is a minimal essential major histocompatibility complex
    J Kaufman
    Institute for Animal Health, Compton, UK
    Nature 401:923-5. 1999
    ..report the sequence of the region that determines rapid allograft rejection in chickens, the chicken major histocompatibility complex (MHC)...
  6. ncbi SYFPEITHI: database for MHC ligands and peptide motifs
    H Rammensee
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Immunogenetics 50:213-9. 1999
    The first version of the major histocompatibility complex (MHC) databank SYFPEITHI: database for MHC ligands and peptide motifs, is now available to the general public...
  7. ncbi Natural selection at major histocompatibility complex loci of vertebrates
    A L Hughes
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Annu Rev Genet 32:415-35. 1998
    The loci of the vertebrate major histocompatibility complex encode cell-surface glycoproteins that present peptides to T cells...
  8. pmc Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations
    Christophe Eizaguirre
    Leibniz Institute for Marine Sciences, Department of Evolutionary Ecology of Marine Fishes, Duesternbrooker Weg 20, 24105 Kiel, Germany
    Nat Commun 3:621. 2012
    The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle...
  9. pmc Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species
    Natasja G de Groot
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunogenetics 64:615-31. 2012
    The major histocompatibility complex (MHC) plays a central role in the adaptive immune response. The MHC region is characterised by a high gene density, and most of these genes display considerable polymorphism...
  10. pmc Interrogating the major histocompatibility complex with high-throughput genomics
    Paul I W de Bakker
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 21:R29-36. 2012
    The major histocompatibility complex (MHC) region on the short arm of chromosome 6 harbors the largest number of replicated associations across the human genome for a wide range of diseases, but the functional basis for these associations ..
  11. pmc Structural and biophysical determinants of αβ T-cell antigen recognition
    John S Bridgeman
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, UK
    Immunology 135:9-18. 2012
    ..and summarize studies that have attempted to correlate the biophysical parameters of TCR/peptide-major histocompatibility complex (pMHC) binding with T-cell activation...
  12. pmc Gene duplication and fragmentation in the zebra finch major histocompatibility complex
    Christopher N Balakrishnan
    Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    BMC Biol 8:29. 2010
    Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects...
  13. ncbi Genetic compatibility, mate choice and patterns of parentage: invited review
    T Tregenza
    Ecology and Evolution Group, School of Biology, University of Leeds, UK
    Mol Ecol 9:1013-27. 2000
    ..This may reflect limitations in the potential for the evolution of mate choice for genetic compatibility within populations, although the most promising sources of such incompatibilities have received relatively little research...
  14. pmc Tricks with tetramers: how to get the most from multimeric peptide-MHC
    Linda Wooldridge
    Department of Medical Biochemistry and Immunology, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff, UK
    Immunology 126:147-64. 2009
    The development of fluorochrome-conjugated peptide-major histocompatibility complex (pMHC) multimers in conjunction with continuing advances in flow cytometry has transformed the study of antigen-specific T cells by enabling their ..
  15. doi The MHC, disease and selection
    John Trowsdale
    Department of Pathology, Tennis Court Road and CIMR, Addenbrookes Site, University of Cambridge, United Kingdom
    Immunol Lett 137:1-8. 2011
    ....
  16. doi Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex
    Mandvi Bharadwaj
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Annu Rev Pharmacol Toxicol 52:401-31. 2012
    ..Recent findings have begun to unearth the mechanistic basis for these HLA associations, and here we review recent advances in the field of HLA-associated drug hypersensitivities...
  17. pmc Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism
    Daniel R Scott
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Mol Biol 414:385-400. 2011
    T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by major histocompatibility complex molecules...
  18. doi Gene conversion rapidly generates major histocompatibility complex diversity in recently founded bird populations
    Lewis G Spurgin
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
    Mol Ecol 20:5213-25. 2011
    ..Genes of the major histocompatibility complex (MHC) are ideal models for studying adaptive genetic variation due to their central role in pathogen ..
  19. doi Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection
    J Guergnon
    INSERM UMR S 945, Paris, France
    J Infect Dis 205:718-24. 2012
    ..Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0...
  20. pmc Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field
    Christophe Eizaguirre
    Department of Evolutionary Ecology of Marine Fishes, GEOMAR Helmholtz Center for Ocean Research, Kiel, 24105, Germany
    Ecol Lett 15:723-31. 2012
    ..The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate ..
  21. doi Spatio-temporal variation in the strength and mode of selection acting on major histocompatibility complex diversity in water vole (Arvicola terrestris) metapopulations
    Matthew K Oliver
    School of Biological Sciences, University of Aberdeen, Zoology Building, Aberdeen AB24 2TZ, Scotland, UK
    Mol Ecol 18:80-92. 2009
    Patterns of spatio-temporal genetic variation at a class II major histocompatibility complex (MHC) locus and multiple microsatellite loci were analysed within and between three water vole metapopulations in Scotland, UK...
  22. ncbi Perspective: detecting adaptive molecular polymorphism: lessons from the MHC
    Daniel Garrigan
    Department of Biology, Arizona State University, Tempe, Arizona 85287 1501, USA
    Evolution 57:1707-22. 2003
    ..Here we review the evidence for balancing selection acting on the major histocompatibility complex (MHC) of vertebrates, a genetic system that defies many of the predictions of neutrality...
  23. pmc High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal
    Andres Aguilar
    Department of Organismic Biology, Ecology, and Evolution, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:3490-4. 2004
    ..5 on MHC loci. These results support the importance of balancing selection as a mechanism to maintain variation in natural populations and expose the difficulty of using neutral markers as surrogates for variation in fitness-related loci...
  24. pmc Complete MHC haplotype sequencing for common disease gene mapping
    C Andrew Stewart
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 14:1176-87. 2004
    ..Here, we report 4.75 Mb of contiguous sequence for each of two common haplotypes of the major histocompatibility complex (MHC), to which susceptibility to >100 diseases has been mapped...
  25. ncbi Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man
    Jerzy K Kulski
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Immunol Rev 190:95-122. 2002
    The major histocompatibility complex (MHC) genomic region is composed of a group of linked genes involved functionally with the adaptive and innate immune systems...
  26. pmc Role of cytokines and major histocompatibility complex restriction in mouse resistance to infection with a natural recombinant strain (type I-III) of Toxoplasma gondii
    Blima Fux
    Laboratory of Immunopathology, René Rachou Research Center, Oswaldo Cruz Foundation, University of Minas Gerais, Brazil
    Infect Immun 71:6392-401. 2003
    ..Further, the C57BL/KsJ and DBA2/J congenic strains containing major histocompatibility complex (MHC) haplotype "d" were more resistant than the parental strains (C57BL/6 and DBA1/J), when infected ..
  27. pmc Major histocompatibility complex (MHC) heterozygote superiority to natural multi-parasite infections in the water vole (Arvicola terrestris)
    M K Oliver
    Institute of Biological and Environmental Sciences, University of Aberdeen, Zoology Building, Aberdeen AB24 2TZ, UK
    Proc Biol Sci 276:1119-28. 2009
    The fundamental role of the major histocompatibility complex (MHC) in immune recognition has led to a general consensus that the characteristically high levels of functional polymorphism at MHC genes is maintained by balancing selection ..
  28. pmc Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
    John D Rioux
    Research Center, Université de Montréal and Montreal Heart Institute, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 106:18680-5. 2009
    ..The data demonstrate that MHC associations with autoimmune diseases result from complex, multilocus effects that span the entire region...
  29. pmc 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells
    Kyung Mi Lee
    Department of Biochemistry, Korea University College of Medicine, Sungbuk Gu, Anam Dong, Seoul 136 705, Korea
    J Exp Med 199:1245-54. 2004
    ..This indicates that 2B4 inhibitory signaling occurs regardless of the presence of SH2D1A. These findings reveal a novel role for 2B4 as a non-major histocompatibility complex binding negative regulator of NK cells.
  30. doi Speciation accelerated and stabilized by pleiotropic major histocompatibility complex immunogenes
    Christophe Eizaguirre
    Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany
    Ecol Lett 12:5-12. 2009
    ..In contrasting niches, parasite communities differ and thus the pools of alleles of the adapted major histocompatibility complex (MHC) also differ between niches...
  31. doi Major histocompatibility complex polymorphism: dynamics and consequences of parasite-mediated local adaptation in fishes
    C Eizaguirre
    Leibniz Institute for Marine Sciences IFM GEOMAR, Department of Evolutionary Ecology of Marine Fishes, Düsternbrooker Weg 20, 24105, Kiel, Germany
    J Fish Biol 77:2023-47. 2010
    ..to this evolutionary pressure, vertebrates have developed genetically coded defences such as the major histocompatibility complex (MHC)...
  32. doi Multiple sclerosis and the major histocompatibility complex
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, UK
    Curr Opin Neurol 22:219-25. 2009
    ..We review here some of the recent findings of MS genetics with a particular focus on genes of the major histocompatibility complex (MHC).
  33. pmc Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history
    James A Traherne
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 2:e9. 2006
    The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease...
  34. pmc Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity
    Steven M Dunn
    Avidex Limited, Abingdon, Oxon, OX14 4RX, UK
    Protein Sci 15:710-21. 2006
    ..Our results suggest that manipulation of germ line CDR2 loops may provide a useful route to the production of high-affinity TCRs with therapeutic and diagnostic potential...
  35. pmc Evolution by the birth-and-death process in multigene families of the vertebrate immune system
    M Nei
    Institute of Molecular Evolutionary Genetics and Department of Biology, The Pennsylvania State University, 328 Mueller Laboratory, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 94:7799-806. 1997
    ..evolution is often invoked to explain the diversity and evolution of the multigene families of major histocompatibility complex (MHC) genes and immunoglobulin (Ig) genes...
  36. ncbi Pathogen resistance and genetic variation at MHC loci
    Philip W Hedrick
    Department of Biology, Arizona State University, Tempe 85287, USA
    Evolution 56:1902-8. 2002
    ..or selection that varies in time and/or space, has been proposed to explain the high variation at major histocompatibility complex (MHC) genes...
  37. ncbi Intense and highly localized gene conversion activity in human meiotic crossover hot spots
    Alec J Jeffreys
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Nat Genet 36:151-6. 2004
    ..and selection methods to characterize sperm conversions in two meiotic crossover hot spots in the major histocompatibility complex (MHC) and one in the sex chromosomal pseudoautosomal pairing region PAR1 (ref. 9)...
  38. ncbi The genetic basis of individual-recognition signals in the mouse
    Sarah A Cheetham
    Mammalian Behaviour and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom
    Curr Biol 17:1771-7. 2007
    The major histocompatibility complex (MHC) is widely assumed to be a primary determinant of individual-recognition scents in many vertebrates [1-6], but there has been no functional test of this in animals with normal levels of genetic ..
  39. doi Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese
    Tao Li
    Bio X Center, Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Biol Psychiatry 68:671-3. 2010
    ..examined 7662 schizophrenic cases and 29053 normal control subjects and reported seven common single nucleotide polymorphisms (SNPs) that were significantly (>10(-8)) associated with schizophrenia...
  40. ncbi Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
    Malkit Sami
    Avidex Limited subsidiary of Medigene Ag, 57C Milton Park, Abingdon, Oxon OX14 4RX, UK
    Protein Eng Des Sel 20:397-403. 2007
    ..Crystal structures of syngeneic TCRs bound to peptide major histocompatibility complex (pMHC) antigens exhibit a conserved mode of binding characterised by a distinct diagonal binding ..
  41. pmc Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination
    Ning Jiang
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Immunity 34:13-23. 2011
    The T cell receptor (TCR) and CD8 bind peptide-major histocompatibility complex (pMHC) glycoproteins to initiate adaptive immune responses, yet the trimolecular binding kinetics at the T cell membrane is unknown...
  42. ncbi Comparative organization and function of the major histocompatibility complex of domesticated cattle
    H A Lewin
    Department of Animal Sciences, University of Illinois at Urbana Champaign 61801, USA
    Immunol Rev 167:145-58. 1999
    This review focuses on recent advances in research on the bovine major histocompatibility complex (BoLA), with specific reference to the genetic organization, polymorphism and function of the class II genes...
  43. doi MHC-correlated mate choice in humans: a review
    Jan Havlicek
    Department of Anthropology, Faculty of Humanities, Charles University, Husnikova 2075, 155 00 Prague, Czech Republic
    Psychoneuroendocrinology 34:497-512. 2009
    Extremely high variability in genes of the major histocompatibility complex (MHC) in vertebrates is assumed to be a consequence of frequency-dependent parasite-driven selection and mate preferences based on promotion of offspring ..
  44. doi MHC-based mate choice combines good genes and maintenance of MHC polymorphism
    C Eizaguirre
    Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Ploen, Germany
    Mol Ecol 18:3316-29. 2009
    Polymorphic genes of the major histocompatibility complex (MHC) are regarded as essential genes for individual fitness under conditions of natural and sexual selection...
  45. pmc High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions
    Lisa F Barcellos
    Division of Epidemiology, School of Public Health, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 5:e1000696. 2009
    A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21...
  46. pmc Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus
    M F Flajnik
    Department of Microbiology and Immunology, University of Miami, FL 33101
    Proc Natl Acad Sci U S A 88:537-41. 1991
    Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis...
  47. ncbi Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication
    L Shen
    Children s Hospital Research Foundation, Columbus, Ohio 43205
    J Biol Chem 269:8466-76. 1994
    ..Duplication of the RCCX modules probably occurred before the speciation of great apes and humans as they contain the same breakpoint region of RP and Gene X gene duplication...
  48. ncbi Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group
    J L Haines
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston, MA, USA
    Hum Mol Genet 7:1229-34. 1998
    ..The only consistently replicated finding has been an association with the HLA-DR2 allele within the major histocompatibility complex (MHC) on chromosome 6...
  49. ncbi Relating amino acid sequence to phenotype: analysis of peptide-binding data
    M R Segal
    Division of Biostatistics, University of California, San Francisco 94143 0560, USA
    Biometrics 57:632-42. 2001
    ..The present application examines whether peptides that bind to a particular major histocompatibility complex (MHC) class I molecule have characteristic amino acid sequences...
  50. ncbi How selection shapes variation of the human major histocompatibility complex: a review
    D Meyer
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Ann Hum Genet 65:1-26. 2001
    The nature of polymorphism and molecular sequence variation in the genes of the human major histocompatibility complex (MHC) provides strong support for the idea that these genes are under selection...
  51. pmc Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues
    Lara S Carroll
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0841, USA
    Proc Natl Acad Sci U S A 99:2187-92. 2002
    Genes of the major histocompatibility complex (MHC) play a central role in immune recognition, yet they also influence the odor of individuals...
  52. ncbi The MHC haplotype project: a resource for HLA-linked association studies
    R J N Allcock
    University of Cambridge, UK
    Tissue Antigens 59:520-1. 2002
  53. pmc Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells
    Willem W Overwijk
    National Cancer Institute NCI, National Institute of Health, Bethesda, MD 20892 1502, USA
    J Exp Med 198:569-80. 2003
    ....
  54. ncbi Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10
    M Moreno
    Population Genetics, Mutacarcinogenesis and Genetic Epidemiology Group, Institute of Biology, University of Antioquia, Medellin, Colombia
    Tissue Antigens 64:18-24. 2004
    Association between the major histocompatibility complex (MHC) and the susceptibility/resistance to acquire Chagas' disease has been largely demonstrated...
  55. pmc The course of malaria in mice: major histocompatibility complex (MHC) effects, but no general MHC heterozygote advantage in single-strain infections
    Claus Wedekind
    Zoological Institute, Division of Conservation Biology, University of Bern, 3012 Bern, Switzerland
    Genetics 170:1427-30. 2005
    ..However, the MHC heterozygotes did worse than expected from the average response of the homozygotes...
  56. ncbi MHC, TSP, and the origin of species: from immunogenetics to evolutionary genetics
    Jan Klein
    Department of Biology, The Pennsylvania State University, University Park, PA 16801, USA
    Annu Rev Genet 41:281-304. 2007
    The acronym Mhc, major histocompatibility complex, is customarily not allied with topics in evolutionary biology...
  57. pmc The human Major Histocompatibility Complex as a paradigm in genomics research
    Claire Vandiedonck
    Wellcome Trust Centre for Human Genetics WTCHG, University of Oxford, Oxford, UK
    Brief Funct Genomic Proteomic 8:379-94. 2009
    Since its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research...
  58. pmc Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains
    Jessica M Boname
    School of Clinical Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Traffic 11:210-20. 2010
    ..is an E3 ligase that ubiquitinates and downregulates several cell surface immunoreceptors, including major histocompatibility complex (MHC) class I molecules...
  59. pmc Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability
    Scott R Burrows
    Cellular Immunology Laboratory, Queensland Institute of Medical Research and Australian Centre for Vaccine Development, Brisbane 4029, Australia
    Proc Natl Acad Sci U S A 107:10608-13. 2010
    ..T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecules; however, the basis for this MHC specificity remains unclear...
  60. doi Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus
    Juan Antonio Figueroa Castillo
    Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, 04510, Mexico, D F, Mexico
    Vet Parasitol 177:339-44. 2011
    ..or susceptibility to Haemonchus contortus infestation and to evaluate the participation of the ovine major histocompatibility complex (MHC) in Pelibuey sheep, a prevalent breed in tropical and sub-tropical regions in Mexico and ..
  61. doi How T cell receptors interact with peptide-MHCs: a multiple steered molecular dynamics study
    Michel A Cuendet
    Swiss Institute of Bioinformatics, Genopode, 1015 Lausanne, Switzerland
    Proteins 79:3007-24. 2011
    The T-cell receptor (TCR) interaction with antigenic peptides (p) presented by the major histocompatibility complex (MHC) molecule is a key determinant of immune response...
  62. doi Colonizing the world in spite of reduced MHC variation
    L Gangoso
    Department of Wetland Ecology, Estacion Biologica de Donana, CSIC, Seville, Spain
    J Evol Biol 25:1438-47. 2012
    The major histocompatibility complex (MHC), which harbours the most polymorphic vertebrate genes, plays a critical role in the host-pathogen coevolutionary arms race...
  63. ncbi Evolutionary genetics of Carpodacus mexicanus, a recently colonized host of a bacterial pathogen, Mycoplasma gallisepticum
    Christopher M Hess
    Department of Biology, University of Washington, Seattle, USA
    Genetica 129:217-25. 2007
    ..These results will be further expanded using experimental studies as well as examination of evolution of the pathogen genome itself...
  64. ncbi A linkage disequilibrium map of the MHC region based on the analysis of 14 loci haplotypes in 50 French families
    A Sanchez-Mazas
    Department of Anthropology and Ecology, University of Geneva, Switzerland
    Eur J Hum Genet 8:33-41. 2000
    ..Several hypotheses including selection, but also unequal allelic diversity at different MHC loci are discussed to explain this complex pattern of linkage disequilibrium...
  65. ncbi Consequences of population structure on genes under balancing selection
    C A Muirhead
    Department of Integrative Biology, University of California, Berkeley 94720 3140, USA
    Evolution 55:1532-41. 2001
    ..genes under strong balancing selection of the type seen in plant self-incompatibility systems and the major histocompatibility complex (MHC) system of vertebrates...
  66. ncbi The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage
    Max Brenner
    Laboratory of Experimental Rheumatology, R S Boas Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Arthritis Rheum 52:322-32. 2005
    ....
  67. doi MHC heterozygosity and survival in red junglefowl
    Kirsty Worley
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK
    Mol Ecol 19:3064-75. 2010
    Genes of the major histocompatibility complex (MHC) form a vital part of the vertebrate immune system and play a major role in pathogen resistance...
  68. doi Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia
    Ingrid Agartz
    Institute of Clinical Medicine, Department of Biostatistics, University of Oslo, Oslo, Norway
    Biol Psychiatry 70:696-8. 2011
    ..from genetic linkage and genome-wide association studies, as well as suggested involvement of infection, the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1 has been implicated in the development of schizophrenia.
  69. doi Major histocompatibility complex variation in insular populations of the Egyptian vulture: inferences about the roles of genetic drift and selection
    Rosa Agudo
    Department of Conservation Biology, Doñana Biological Station CSIC, Avenida Americo Vespucio s n, E 41092 Sevilla, Spain
    Mol Ecol 20:2329-40. 2011
    ..Genes of the major histocompatibility complex (MHC) are classical examples of evolutionarily relevant loci because of their well-known role in ..
  70. pmc Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex
    Claire Vandiedonck
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Genome Res 21:1042-54. 2011
    The human major histocompatibility complex (MHC) on chromosome 6p21 is a paradigm for genomics, showing remarkable polymorphism and striking association with immune and non-immune diseases...
  71. pmc The IMGT/HLA database
    James Robinson
    HLA Informatics Group, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    Nucleic Acids Res 41:D1222-7. 2013
    ..This article describes the latest updates and additional tools added to the IMGT/HLA project...
  72. pmc Determining the one, two, three, or four long and short loci of human complement C4 in a major histocompatibility complex haplotype encoding C4A or C4B proteins
    Erwin K Chung
    Children s Research Institute, Columbus, OH 43205, USA
    Am J Hum Genet 71:810-22. 2002
    ..frequent variations in the size and number of C4A and C4B, as well as their neighboring genes, in the major histocompatibility complex has been a hurdle for accurate epidemiological studies of diseases associated with C4...
  73. ncbi Upregulation of major histocompatibility complex class II antigens in hepatocytes in Doberman hepatitis
    M Speeti
    Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, P O Box 57, 00014 Helsinki, Finland
    Vet Immunol Immunopathol 96:1-12. 2003
    b>Major histocompatibility complex (MHC) class II antigen expression in hepatocytes and its correlation with mononuclear cell infiltration into the liver were studied using immunohistochemical techniques in 38 Dobermans with Doberman ..
  74. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  75. pmc Major histocompatibility complex variation in the endangered Przewalski's horse
    P W Hedrick
    Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
    Genetics 152:1701-10. 1999
    The major histocompatibility complex (MHC) is a fundamental part of the vertebrate immune system, and the high variability in many MHC genes is thought to play an essential role in recognition of parasites...
  76. doi Polymorphic MHC loci in an asexual fish, the amazon molly (Poecilia formosa; Poeciliidae)
    Helmut Schaschl
    Konrad Lorenz Institute for Ethology, Austrian Academy of Sciences, Savoyenstrasse 1a, 1160 Vienna, Austria
    Mol Ecol 17:5220-30. 2008
    Genes of the major histocompatibility complex (MHC) encode molecules that control immune recognition and are highly polymorphic in most vertebrates...
  77. doi Opposites attract: MHC-associated mate choice in a polygynous primate
    J M Setchell
    Evolutionary Anthropology Research Group, Department of Anthropology, Durham University, Durham, UK
    J Evol Biol 23:136-48. 2010
    ..in relation to genetic relatedness and male genetic characteristics, using neutral microsatellite and major histocompatibility complex (MHC) genotyping...
  78. doi A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population
    Kouichi Asano
    Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama Institute, Yokohama, Japan
    Nat Genet 41:1325-9. 2009
    ..In addition to the expected strong association with the major histocompatibility complex (MHC) region, we identified three new susceptibility loci: the immunoglobulin receptor gene FCGR2A (..
  79. ncbi The gene conversion hypothesis of MHC evolution: a review
    J T Martinsohn
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, D 50674 Cologne, Germany
    Immunogenetics 50:168-200. 1999
    Gene conversion is often invoked to explain the evolution of sequence patterns observed in major histocompatibility complex (MHC) genes and their alleles. This is the gene conversion hypothesis of MHC sequence evolution...
  80. ncbi Major histocompatibility complex variation at three class II loci in the northern elephant seal
    Diana S Weber
    Department of Biological Sciences, University at Albany, State University of New York, Washington Avenue, Albany, NY, USA
    Mol Ecol 13:711-8. 2004
    ..Northern elephant seals are evidently inbred, although there is as yet no evidence of correlative reductions in fitness...
  81. pmc The complex genetics of multiple sclerosis: pitfalls and prospects
    Stephen Sawcer
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 131:3118-31. 2008
    ..Although focused almost exclusively on multiple sclerosis all the points made are essentially generic and apply equally well, with relatively minor addendums, to any other complex trait, neurological or otherwise...
  82. pmc Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex
    M A King
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Clin Exp Immunol 157:104-18. 2009
    ..As in human disease, the development of xenogeneic GVHD is highly dependent on expression of host major histocompatibility complex class I and class II molecules and is associated with severely depressed haematopoiesis...
  83. doi Genetic diversity and differentiation at MHC genes in island populations of tuatara (Sphenodon spp.)
    Hilary C Miller
    Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Mol Ecol 19:3894-908. 2010
    ..The genes of the major histocompatibility complex (MHC) are well-known examples of genes of adaptive significance and are particularly relevant to ..
  84. pmc Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    Kai Wang
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:2059-67. 2010
    ..Furthermore, the strongest risk alleles for T1D within the major histocompatibility complex (MHC) confer strong protection against CD and UC; however, given the multi-allelic nature of the MHC ..
  85. ncbi The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids
    S A Porcelli
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Immunol 17:297-329. 1999
    ..CD1 family of proteins as novel antigen-presenting molecules encoded by genes located outside of the major histocompatibility complex. CD1 proteins are conserved in all mammalian species so far examined and are prominently expressed on ..
  86. doi Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection
    Danielle Van Manen
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS 23:19-28. 2009
    ....
  87. pmc Common variants on chromosome 6p22.1 are associated with schizophrenia
    Jianxin Shi
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    Nature 460:753-7. 2009
    ..schizophrenia is significantly associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibility complex region on chromosome 6...
  88. ncbi Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40
    R G Parton
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Immunol Rev 168:23-31. 1999
    ..The subsequent steps by which SV40 reaches the ER remain unclear but recent evidence suggests that this pathway may be shared with several other proteins that are transported from surface caveolae to the ER...
  89. doi Mate choice for nonadditive genetic benefits correlate with MHC dissimilarity in the rose bitterling (Rhodeus ocellatus)
    Muna Agbali
    School of Biology, University of St Andrews, St Andrews, Fife KY16 8LB, United Kingdom
    Evolution 64:1683-96. 2010
    ....
  90. pmc Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
    Jurjen H Velthuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:1721-30. 2010
    ..Yet, conventional detection techniques (ELISPOT and HLA tetramers) require many cells and are relatively insensitive...
  91. doi A role for regulatory T cells in acceptance of ESC-derived tissues transplanted across an major histocompatibility complex barrier
    Kathy O Lui
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, United Kingdom
    Stem Cells 28:1905-14. 2010
    ..Moreover, ESC-derived tissues could be spontaneously accepted across a class I major histocompatibility complex disparity...
  92. ncbi Major histocompatibility complex variation in the Arabian oryx
    P W Hedrick
    Department of Biology, Arizona State University, Tempe 95287, USA
    Evolution 54:2145-51. 2000
    ..We have examined the amount of genetic variation for a class II gene in the major histocompatibility complex thought to be the most important genetic basis for pathogen resistance in vertebrates...
  93. ncbi Natural killer cells and pregnancy
    Ashley Moffett-King
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Immunol 2:656-63. 2002
    ....
  94. pmc Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands
    Meera Mallya
    MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge CB10 1SB, United Kingdom
    Protein Sci 15:2244-56. 2006
    ..This characterization of the five MHC class III region Ly-6 family members is of great relevance, as they represent 18% of the human Ly-6 protein family and 50% of the secreted ones...
  95. ncbi Comparative genomics of major histocompatibility complexes
    James Kelley
    Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Immunogenetics 56:683-95. 2005
    The major histocompatibility complex (MHC) is a gene dense region found in all jawed vertebrates examined to date...
  96. ncbi Features of MHC and NK gene clusters
    James Kelley
    Department of Pathology, Immunology Division, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Transpl Immunol 14:129-34. 2005
    ..levels of polymorphism and gene duplication, are present in subsets of immune genes, namely the Major Histocompatibility Complex (MHC) and Natural Killer (NK) cell receptor gene complexes...
  97. ncbi Molecular genotype identification of the Gallus gallus major histocompatibility complex
    Janet E Fulton
    Hy Line International, P O Box 310, Dallas Center, IA, 50063, USA
    Immunogenetics 58:407-21. 2006
    The chicken major histocompatibility complex (MHC) is commonly defined by serologic reactions of erythrocytes with antibodies specific to the highly polymorphic MHC class I (BF) and MHC class IV (BG) antigens...
  98. ncbi Gene flow, effective population size and selection at major histocompatibility complex genes: brown trout in the Hardanger Fjord, Norway
    Michael M Hansen
    Technical University of Denmark Danish Institute for Fisheries Research, Department of Inland Fisheries, Vejlsøvej 39, DK 8600 Silkeborg, Denmark
    Mol Ecol 16:1413-25. 2007
    ..This suggests that similar genetic differences could exist at salmon louse resistance loci, thus rendering it a realistic scenario that differential population declines could reflect differences in adaptive variation...
  99. ncbi Major histocompatibility complex (MHC) variation and susceptibility to the sea louse Lepeophtheirus salmonis in Atlantic salmon Salmo salar
    K A Glover
    Institute of Marine Research, PO Box 1870, Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 76:57-65. 2007
    The relationship between genetic variation in major histocompatibility complex (MHC) Class I and II genes and susceptibility to sea lice Lepeophtheirus salmonis (Krøyer) in Atlantic salmon Salmo salar (L...
  100. pmc Allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques
    Justin M Greene
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 3:e2384. 2008
    ..Previous adoptive transfers in primates have failed as transferred cells are typically cleared within hours after transfer...
  101. doi Major histocompatibility complex heterozygote advantage and widespread bacterial infections in populations of Chinook salmon (Oncorhynchus tshawytscha)
    Melissa L Evans
    Department of Biology, University of Western Ontario, 1151 Richmond St N, London, ON, N6A 5B7, Canada
    Mol Ecol 18:4716-29. 2009
    Despite growing evidence for parasite-mediated selection on the vertebrate major histocompatibility complex (MHC), little is known about variation in the bacterial parasite community within and among host populations or its influence on ..

Research Grants71

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Tibor T Glant; Fiscal Year: 2016
    ..The major genetic contributor is the major histocompatibility complex (MHC)-encoded (human leukocyte antigen) HLA-B27 first described in 1973...
  3. Tibor T Glant; Fiscal Year: 2014
    ..development and severity, and recessive inheritance of disease susceptibility, dictated by both the major histocompatibility complex (MHC)- and non-MHC-associated genes are additional characteristics that make this model an ideal tool ..
  4. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..of allogeneic stem cell transplantation (allo-SCT) mediated by donor T cells that recognize minor and major histocompatibility complex (MHC) differences in the host...
  5. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..Specific Aim 2: to evaluate and validate a putative b2-M receptor, a non-classical major histocompatibility complex (MHC)-like molecule, the hereditary hemochromatosis associated gene, HFE...
  6. Matthew B Grisham; Fiscal Year: 2015
    ..immunosuppressive activity of MSCs in different mouse models of autoimmunity is not restricted to the major histocompatibility complex suggesting that MSCs are "immune-privileged"...
  7. Laurence J N Cooper; Fiscal Year: 2014
    ..specificity of T cells to the B-cell lineage-restricted cell-surface molecule CD19 independent of major histocompatibility complex (MHC)...
  8. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..1) placental trophoblast cells of SCNT fetuses, in contrast to control fetuses, express classical major histocompatibility complex class I (MHC-I) antigens early in pregnancy, (2) T lymphocytes accumulate in the uterine stroma of ..
  9. Jay Reddy; Fiscal Year: 2016
    ..Using major histocompatibility complex (MHC) class II dextramers for cardiac myosin heavy chain (Myhc)-[unreadable] 334-352, the team has ..
  10. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..antigens from phagocytosed bacteria - such as Listeria monocytogenes - are processed and presented by major histocompatibility complex (MHC) class I (MHC-I) and class II (MHC-II) molecules to activate naove pathogen-specific CD8+ and ..
  11. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    ..and US11 gene products have co-opted ERAD to mediate the destruction of the immunological protein major histocompatibility complex (MHC) class I heavy chain to limit viral clearance by cytotoxic T cells...
  12. Kristin A Hogquist; Fiscal Year: 2016
    ..the production of CD4+ T cells expressing T cell receptors (TCR) specific for self peptide (p):major histocompatibility complex II (MHCII) ligands...
  13. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..Conventional CD4+ and CD8+ T cells of the immune system recognize specific peptide antigens bound to major histocompatibility complex (MHC) class II or MHC class I molecules, respectively...
  14. Gad Shaulsky; Fiscal Year: 2015
    ..In mammals, allorecognition is mediated by the Major Histocompatibility Complex (MHC), which is part of the immune system...
  15. Study of the HFE Transferrin Receptor interaction in mammalian iron homeostasis
    Paul Schmidt; Fiscal Year: 2010
    ..HFE is a major histocompatibility complex (MHC) class l-like gene that forms a protein-protein complex with TFR soon after synthesis and is ..
  16. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..by highly polymorphic interactions between killer cell immunoglobulin-like receptors (KIR) and major histocompatibility complex (MHC) I ligands...
  17. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..During the last funding period we developed a sensitive new technique to detect polyclonal peptide-major histocompatibility complex class II molecule (pMHCII)-specific CD4+ T cells and used it to track CD4+ T cells expressing ..
  18. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    REBECCA CYNTHIA OBENG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Major histocompatibility complex (MHC) class I molecules display peptides derived from endogenous proteins that have been degraded within the cell...
  19. Development & Characterization of Tyrosinase Epitope Specific TCR Transgenic Mice
    Shikhar Mehrotra; Fiscal Year: 2010
    ..that are widely expressed by cells of the melanocyte lineage and naturally presented by class I major histocompatibility complex molecules provide targets for vaccination-induced, cytotoxic T lymphocyte (CTL)-based immunotherapy ..
  20. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..we investigated the mechanism of Stat5-mediated lymphomagenesis by exploring the contributions of major histocompatibility complex (MHC)/T-cell receptor (TCR) and pre-TCR signals...
  21. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..methods have been lagging in the zebrafish due to lack of knowledge about the zebrafish Major Histocompatibility Complex (MHC) genes...
  22. Complete genomic DNA sequence of the sooty mangabey MHC
    Daniel E Geraghty; Fiscal Year: 2012
    ..out the following specific aims: (1) To derive complete and high quality genomic sequences of the major histocompatibility complex (MHC) and killer Ig-like receptor (KIR) regions from the sooty mangabey...
  23. Down-regulation of MHC class l molecules by HCMV US2
    Domenico Tortorella; Fiscal Year: 2009
    ..US11 interfere with CTL recognition of HCMV-infected cells by preventing the surface expression of major histocompatibility complex (MHC) class I molecules...
  24. T Cell Modulation by NKG2D
    Thomas Spies; Fiscal Year: 2013
    ..Ligands of NKG2D in humans include the major histocompatibility complex class I-related chain A (MICA), which is frequently expressed in epithelial tumors and certain ..
  25. Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral
    Ann F Cheung; Fiscal Year: 2010
    ..Utilizing a proteomics approach, major histocompatibility complex (MHC) class I- presented peptides will be extracted and sequenced from HLA-A2+ ovarian cancer cell ..
  26. From destructive to protective: altering the fate of a diabetogenic T cell using
    JENNIFER DIANNA HOOD; Fiscal Year: 2012
    ..acids that contact the T cell receptor, we propose that by changing amino acids that contact the major histocompatibility complex (MHC) we can alter T cell fate without the disadvantages of APLs...
  27. DOUGLAS FREDERICK LEVINSON; Fiscal Year: 2015
    ..The strongest common- SNP signal spans the Major Histocompatibility Complex (MHC, chromosome 6p21) which includes the human leukocyte antigen (HLA) loci...
  28. Malini Raghavan; Fiscal Year: 2016
    Assembly of major histocompatibility complex (MHC) class I molecules occurs within the endoplasmic reticulum (ER) of cells...
  29. DAIVA MARIA MATTIS; Fiscal Year: 2014
    ..provided by applicant): T cell receptors recognize peptide antigens bound to and presented by the major histocompatibility complex (MHC) in a highly specific manner...
  30. PETER R PARHAM; Fiscal Year: 2016
    ..in immunity and reproduction are variable receptors that recognize polymorphic determinants of major histocompatibility complex (MHC) class I molecules...
  31. Joyce C Solheim; Fiscal Year: 2014
    ..this cancer are poorly understood, although there have been reports of down-regulated expression of major histocompatibility complex (MHC) class I molecules, and correlation of decreased MHC class I expression and poor survival...
  32. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..We have mapped PSORS1, the major psoriasis susceptibility gene in the major histocompatibility complex (MHC), to within or very near HLA-Cw6 by DNA sequencing and recombinant ancestral haplotype mapping...
  33. Peter Cresswell; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Major Histocompatibility Complex (MHC) class I glycoproteins, the products of HLA-A, B and C genes in humans, are critical for T cell mediated immune responses to viruses and intracellular pathogens...
  34. Richard S Blumberg; Fiscal Year: 2014
    CDId is a major histocompatibility complex (MHC) class 1-related molecule that is expressed by intestinal epithelial cells (lEC), hepatocytes and professional antigen presenting cejls (APCs) including dendritic cells (DC), monocytes and B ..
  35. Luc Teyton; Fiscal Year: 2015
    ..for both conditions, we have decided to study the mechanisms underlying their association to the same Major Histocompatibility Complex (MHC) class II molecules, HLA-DQ8...
  36. Carole Ober; Fiscal Year: 2016
    ..underlie chronic airway inflammation with a clear focus on one immune tolerance molecule, the class I major histocompatibility complex protein human leukocyte antigen (HLA)-G, that we believe has an important role in modulating airway ..
  37. Bioengineered siRNA/Nanoparticles to Prevent Human Transplant Rejection
    George Tellides; Fiscal Year: 2013
    ..rodents, have circulating effector memory T cells capable of directly recognizing non-self-major histocompatibility complex (MHC) molecules and, upon activation, causing graft rejection...
  38. A Recombinant Protein Vaccine Against Coccidioidomycosis
    GARRY THOMAS COLE; Fiscal Year: 2012
    ..In Specific Aim 3, we will incorporate selected promiscuous, human major histocompatibility complex ((MHC) II-binding epitopes identified in vaccine candidates with the highest protective efficacy, as ..
  39. OLGA AFANASIEV; Fiscal Year: 2014
    ..The mechanisms and reversibility of Major Histocompatibility Complex class I (MHC-I) down-regulation will be explored in Aim 3...
  40. N Louise Glass; Fiscal Year: 2014
    ..Similar to other nonself recognition loci, such as the Major Histocompatibility Complex (MHC) in jawed vertebrates, het loci in N. crassa show evidence of balancing selection...
  41. Aaron W Michels; Fiscal Year: 2016
    ..by which 'drug- like'small molecules can be used to block the underlying autoimmunity in major histocompatibility complex (MHC) class II restricted autoimmune diseases...
  42. Molecular Genetics of BAT Genes and SLE Risk
    F Yesim Demirci; Fiscal Year: 2013
    ..There is compelling evidence for the involvement of the Major Histocompatibility Complex (MHC) locus on chromosome 6p21...
  43. The MHC of wild chimpanzees: genetic variation, disease and reproductive success
    EMILY ELIZABETH WROBLEWSKI; Fiscal Year: 2012
    The major histocompatibility complex (MHC) is a cluster of genes critical to the immune response since it codes for antigen-presenting proteins in all vertebrates...
  44. Antigen processing and the age-related decline in protection against influenza
    Tara Robinson; Fiscal Year: 2011
    ..In turn, CD4+ T lymphocytes are activated by foreign peptides presented in the context of major histocompatibility complex (MHC) class II molecules...
  45. New Vaccine against Influenza
    Mingtao Zeng; Fiscal Year: 2011
    ..Since the anthrax toxins are capable of entering host cells for antigen delivery through the major histocompatibility complex (MHC) class I and class II pathways, the proposed vaccine may elicit potent cell-mediated immunity ..
  46. Analysis of peripheral tolerance in vivo
    MARC KEVIN JENKINS; Fiscal Year: 2013
    ..the production of CD4+ T cells expressing T cell receptors (TCR) specific for self peptide (p):major histocompatibility complex II (MHCII) ligands displayed in the thymus...
  47. Defining the importance of CD8+ T Cell Breadth in SIV/HIV protective immunity
    DAVID H O'CONNOR; Fiscal Year: 2013
    ..These experiments rely on groups of MCM that are either homozygous or heterozygous for major histocompatibility complex (MHC) class I genes that present SIV-derived peptides to T cells...
  48. IFN-Is at the interface of Innate and Adapative Immunity
    Christian W Schindler; Fiscal Year: 2010
    ..differences in IFN-I stimulated Statl activation and a loss in the normal regulation of the Major Histocompatibility Complex class II (MHC-II)...
  49. Tony L Yaksh; Fiscal Year: 2016
    ..In response to peripheral nerve damage, T helper (Th) lymphocyte trafficking and induction of major histocompatibility complex (MHC) II (essential to the capture and antigen presentation for Th cell recognition) in the injured ..
  50. Complement Genetics and Clinical Variability of Systemic Lupus Erythematosus
    CHACK Y YU; Fiscal Year: 2012
    ..Located in the central region of major histocompatibility complex (MHC) on the short arm of the chromosome 6, there can be one to five copies of structural genes for ..
  51. Radiation Dose-Dependent Interventions
    George Earl Georges; Fiscal Year: 2010
    ..exposed to 7 to 10 Gy, Project 5 will optimize donor engraftment and rapid neutrophil recovery using major histocompatibility complex (MHC)-mismatched umbilical cord blood (UCB), thousands of units of which are already cryopreserved...
  52. Regulation of the MHC Class II Transactivator CIITA
    Jeremy M Boss; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Major histocompatibility complex (MHC) class I molecules present antigens to the adaptive immune system...
  53. ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLY
    Joyce Solheim; Fiscal Year: 2009
    ..g. infections, tumors, transplantation rejection, and autoimmunity. Cell surface major histocompatibility complex (MHC) class I molecules present tumor- or pathogen-specific peptides to T cells, which respond by ..
  54. Evolution and Ancestral Functions of a Human MHC Class I Pseudogene, HLA-Y
    ANA S GOYOS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Genes of the Major Histocompatibility Complex (MHC) present a paradigm for how selection can act to maintain (or eliminate) adaptively important (or detrimental) genetic diversity in natural ..
  55. HLA*B Associated Genes and Memory B cells in patients with CVID
    Harry Schroeder; Fiscal Year: 2009
    ..our clinic population of CVID patients in the Southeastern US, the greatest genetic linkage is to the major histocompatibility complex (MHC) on chromosome 6, with almost half inheriting HLA*B44...
  56. Christine F Skibola; Fiscal Year: 2014
    ..Based on findings from two GWAS of NHL, SNPs and HLA alleles on chromosome band 6p21.32-33 in the major histocompatibility complex (MHC) region were associated with risk of follicular lymphoma (FL), one of the major subtypes of NHL...
  57. RICHARD JAMES REYNOLDS; Fiscal Year: 2015
    ..are already available for 9,484 single nucleotide polymorphisms (SNPs) based on the International Major Histocompatibility Complex (MHC) and Autoimmunity Genetics Network (IMAGEN) SNP array...
  58. Replication of Association Signals Identified in Ulcerative Colitis GWAS
    Richard H Duerr; Fiscal Year: 2010
    ..Variants in IL23R and the major histocompatibility complex are associated with both ulcerative colitis and Crohn's disease, but most of the identified ..
  59. Immune Response Gene Polymorphisms and AMD: Examining HLA-KIR Epistasis
    Gregory J Tranah; Fiscal Year: 2013
    ..In this context, human leukocyte antigen (HLA) polymorphisms, encoded within the major histocompatibility complex (MHC), and killer immunoglobulin-like receptors (KIR) are of particular interest...
  60. Judy H Cho; Fiscal Year: 2016
    ..data are provided detailing a) the genetic architecture of IBD, with the unique absence of a dominant major histocompatibility complex in Crohn's disease, b) the precise nature of the population substructure between Jewish and non-..
  61. The Role of Microglia during TMEV-IDD in the Adult Mouse
    DANNE S DUNCAN; Fiscal Year: 2010
    ..will be examined for their functional ability to enhance antigen presentation (co- stimulation and major histocompatibility complex expression &T lymphocyte activation and proliferation) properties at distinct (anti-viral and ..
  62. Modulation of tumor susceptibility to NK cells induced by JAK family genes
    Roberto Bellucci; Fiscal Year: 2012
    ..Unlike T and B cells, NK do not recognize antigens in the context of classical major histocompatibility complex (MHC) but they lyse tumor cells without specific antigen recognition...
  63. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the applicant's abstract) - The major histocompatibility complex (MHC) is an important susceptibility locus for many human autoimmune diseases...
  64. NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid Liposomes
    Peng Wang; Fiscal Year: 2007
    ..Conventional CD4+ and CD8+ T cells of the immune system recognize specific peptide antigens bound to major histocompatibility complex (MHC) class II or MHC class I molecules, respectively...
  65. REGULATION OF MHC GENES IN TROPHOBLAST
    DOUGLAS ANTCZAK; Fiscal Year: 1999
    ..mechanism that ensures maternal tolerance of the fetal allograft is the regulation of expression of Major Histocompatibility Complex (MHC) class I and class II antigens on the trophoblast cells that comprise the physical barrier ..
  66. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 2000
    ..FcRn is very similar in structure to class I major histocompatibility complex proteins...
  67. LMP POLYMORPHISMS IN B27-ASSOCIATED JUVENILE ARTHRITIS
    Robert Colbert; Fiscal Year: 2001
    ..One genetic factor encoded in the class I region of the major histocompatibility complex (MHC), and associated with late onset particular JRA, is HLA-B27...