genetic research

Summary

Summary: Research into the cause, transmission, amelioration, elimination, or enhancement of inherited disorders and traits.

Top Publications

  1. pmc Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group
    Richard R Fabsitz
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Epidemiology Branch, 6701 Rockledge Drive MSC 7935, Bethesda, MD20892, USA
    Circ Cardiovasc Genet 3:574-80. 2010
  2. ncbi Genomics really gets personal: how exome and whole genome sequencing challenge the ethical framework of human genetics research
    Holly K Tabor
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Am J Med Genet A 155:2916-24. 2011
  3. pmc Experiences with community engagement and informed consent in a genetic cohort study of severe childhood diseases in Kenya
    Vicki M Marsh
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    BMC Med Ethics 11:13. 2010
  4. pmc Impact of social stigma on the process of obtaining informed consent for genetic research on podoconiosis: a qualitative study
    Fasil Tekola
    School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia
    BMC Med Ethics 10:13. 2009
  5. ncbi How to interpret a genome-wide association study
    Thomas A Pearson
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    JAMA 299:1335-44. 2008
  6. ncbi Feedback of individual genetic results to research participants: in favor of a qualified disclosure policy
    Annelien L Bredenoord
    Department of Medical Ethics, University Medical Center Utrecht, Division Julius Center, Utrecht, The Netherlands
    Hum Mutat 32:861-7. 2011
  7. ncbi Internet cognitive testing of large samples needed in genetic research
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 10:554-63. 2007
  8. pmc Public expectations for return of results from large-cohort genetic research
    Juli Murphy
    Genetics and Public Policy Center, Berman Institute of Bioethics, Johns Hopkins University, Washington, DC 20036, USA
    Am J Bioeth 8:36-43. 2008
  9. pmc Voluntary participation and informed consent to international genetic research
    Patricia A Marshall
    Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4976, USA
    Am J Public Health 96:1989-95. 2006
  10. ncbi Subjects matter: a survey of public opinions about a large genetic cohort study
    David Kaufman
    Genetics and Public Policy Center, Johns Hopkins University, Washington, DC 20036, USA
    Genet Med 10:831-9. 2008

Detail Information

Publications241 found, 100 shown here

  1. pmc Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group
    Richard R Fabsitz
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Epidemiology Branch, 6701 Rockledge Drive MSC 7935, Bethesda, MD20892, USA
    Circ Cardiovasc Genet 3:574-80. 2010
    ..of a 2004 National Heart, Lung, and Blood Institute Working Group focused on Guidelines to the Return of Genetic Research Results...
  2. ncbi Genomics really gets personal: how exome and whole genome sequencing challenge the ethical framework of human genetics research
    Holly K Tabor
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Am J Med Genet A 155:2916-24. 2011
    ..We provide broad guidance about interim ways to contend with these issues and make broad recommendations for areas for novel resource and policy development...
  3. pmc Experiences with community engagement and informed consent in a genetic cohort study of severe childhood diseases in Kenya
    Vicki M Marsh
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    BMC Med Ethics 11:13. 2010
    ....
  4. pmc Impact of social stigma on the process of obtaining informed consent for genetic research on podoconiosis: a qualitative study
    Fasil Tekola
    School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia
    BMC Med Ethics 10:13. 2009
    ..The aim of this study was to explore the impact of social stigma on the process of obtaining consent for a study on the genetics of podoconiosis in Southern Ethiopia...
  5. ncbi How to interpret a genome-wide association study
    Thomas A Pearson
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    JAMA 299:1335-44. 2008
    ..This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance...
  6. ncbi Feedback of individual genetic results to research participants: in favor of a qualified disclosure policy
    Annelien L Bredenoord
    Department of Medical Ethics, University Medical Center Utrecht, Division Julius Center, Utrecht, The Netherlands
    Hum Mutat 32:861-7. 2011
    This article discusses whether and when researchers have a moral obligation to feedback individual genetic research results...
  7. ncbi Internet cognitive testing of large samples needed in genetic research
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 10:554-63. 2007
    Quantitative and molecular genetic research requires large samples to provide adequate statistical power, but it is expensive to test large samples in person, especially when the participants are widely distributed geographically...
  8. pmc Public expectations for return of results from large-cohort genetic research
    Juli Murphy
    Genetics and Public Policy Center, Berman Institute of Bioethics, Johns Hopkins University, Washington, DC 20036, USA
    Am J Bioeth 8:36-43. 2008
    ..Recognizing the wide range of possible research results from a large cohort study, they repeatedly and spontaneously suggested that cohort study participants be given ongoing choices as to which results they received...
  9. pmc Voluntary participation and informed consent to international genetic research
    Patricia A Marshall
    Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4976, USA
    Am J Public Health 96:1989-95. 2006
    ..We compared voluntary participation and comprehension of informed consent among individuals of African ancestry enrolled in similarly designed genetic studies of hypertension in the United States and Nigeria...
  10. ncbi Subjects matter: a survey of public opinions about a large genetic cohort study
    David Kaufman
    Genetics and Public Policy Center, Johns Hopkins University, Washington, DC 20036, USA
    Genet Med 10:831-9. 2008
    ..To this end, 4659 Americans were surveyed about support for and willingness to participate in a proposed large cohort study...
  11. pmc Investigating the potential for ethnic group harm in collaborative genomics research in Africa: is ethnic stigmatisation likely?
    Jantina de Vries
    The Ethox Centre, Department of Public Health, University of Oxford, UK
    Soc Sci Med 75:1400-7. 2012
    ....
  12. pmc IRB perspectives on the return of individual results from genomic research
    Lynn G Dressler
    Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, NC, USA
    Genet Med 14:215-22. 2012
    ..However, the perspective of key stakeholders-institutional review board (IRB) professionals-has been missing from this dialogue. This study explores the positions and experiences of IRB members and staff regarding this issue...
  13. ncbi Attitudes towards biomedical use of tissue sample collections, consent, and biobanks among Finns
    Aaro Tupasela
    Department of Sociology, University of Helsinki, Helsinki, Finland
    Scand J Public Health 38:46-52. 2010
    ..To ascertain the attitudes towards the use of existing diagnostic and research samples, the setting up of a national biobank, and different types of informed consent among Finns...
  14. ncbi The adequacy of informed consent forms in genetic research in Oman: a pilot study
    Asya Al-Riyami
    Ministry of Health, Oman and Research and Ethics Committee, Sultanate of Oman
    Dev World Bioeth 11:57-62. 2011
    b>Genetic research presents ethical challenges to the achievement of valid informed consent, especially in developing countries with areas of low literacy...
  15. pmc The effect of next-generation sequencing technology on complex trait research
    Aaron G Day-Williams
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Eur J Clin Invest 41:561-7. 2011
    ..Advances in the understanding of complex trait genetics have always been enabled by advances in genomic technology. Next-generation sequencing (NGS) is set to revolutionize the way complex trait genetics research is carried out...
  16. ncbi Transforming genetic research practices with marginalized communities: a case for responsive justice
    Sara Goering
    Hastings Cent Rep 38:43-53. 2008
    ....
  17. ncbi Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma
    E Melen
    Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 272:108-20. 2012
    ..Finally, we discuss how genetic and environmental factors jointly influence asthma susceptibility and summarize how the results may increase understanding of the pathophysiology of asthma-related diseases...
  18. ncbi Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness
    Blair H Smith
    Medical Research Institute, University of Dundee, Dundee, UK
    Int J Epidemiol 42:689-700. 2013
    ..These features were designed to maximize the power of the resource to identify, replicate or control for genetic factors associated with a wide spectrum of illnesses and risk factors, both now and in the future...
  19. ncbi Researchers' preferences and attitudes on ethical aspects of genomics research: a comparative study between the USA and Spain
    M Ruiz-Canela
    Department of Biomedical Humanities, University of Navarra, Pamplona Spain
    J Med Ethics 35:251-7. 2009
    ..However, there are no quantitative data regarding researchers' attitudes about these issues...
  20. pmc Informed consent in genomics and genetic research
    Amy L McGuire
    Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Genomics Hum Genet 11:361-81. 2010
    ..All of these models attempt to balance the obligation to respect and protect research participants with the larger social interest in advancing beneficial research as quickly as possible...
  21. pmc Public preferences regarding the return of individual genetic research results: findings from a qualitative focus group study
    Juli Murphy Bollinger
    Genetics and Public Policy Center, Berman Institute of Bioethics, Johns Hopkins University, Washington, DC, USA
    Genet Med 14:451-7. 2012
    People are interested in receiving their individual research results in exchange for participating in genetic research. However, it is unclear whether the public understands the nature and limitations of these results and whether they ..
  22. pmc Researcher perspectives on disclosure of incidental findings in genetic research
    Meredith C Meacham
    University of Washington s Institute of Public Health Genetics Master of Public Health program, Seattle, WA 98195 7120, USA
    J Empir Res Hum Res Ethics 5:31-41. 2010
    b>Genetic research can produce information that is beyond the aims of the research study yet may be of clinical or personal interest to study participants...
  23. ncbi Opinions of children about participation in medical genetic research
    S van der Pal
    TNO Quality of Life, Prevention and Health, Youth Department, Leiden, The Netherlands
    Public Health Genomics 14:271-8. 2011
    ..The objective was to evaluate children's opinions about their participation in a large research project...
  24. ncbi Genetic research and donation of tissue samples to biobanks. What do potential sample donors in the Swedish general public think?
    Asa Kettis-Lindblad
    Department of Pharmacy, Uppsala University, Sweden
    Eur J Public Health 16:433-40. 2006
    ....
  25. ncbi Clinical utility and full disclosure of genetic results to research participants
    Richard R Sharp
    Center for Medical Ethics and Health Policy, Baylor College of Medicine, USA
    Am J Bioeth 6:42-4; author reply W10-2. 2006
  26. ncbi Obligations in offering to disclose genetic research results
    Conrad V Fernandez
    Dalhousie University, Canada
    Am J Bioeth 6:44-6; author reply W10-2. 2006
  27. ncbi DNA on loan: issues to consider when carrying out genetic research with aboriginal families and communities
    Laura Arbour
    University of British Columbia, Vancouver, Canada
    Community Genet 9:153-60. 2006
    ..This paper will explore practical ways of maintaining a respectful research relationship when genetics research with aboriginal people is undertaken...
  28. pmc Two large-scale surveys on community attitudes toward an opt-out biobank
    Kyle B Brothers
    Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Am J Med Genet A 155:2982-90. 2011
    ....
  29. ncbi Genotyping technologies for genetic research
    Jiannis Ragoussis
    Genomics Laboratory, Wellcome Trust Centre for Human Genetics, Oxford University, Oxford OX3 7BN, United Kingdom
    Annu Rev Genomics Hum Genet 10:117-33. 2009
    ..It is anticipated that in the future, sample throughput and cost savings will be increased further through the combination of automation, microfluidics, and nanotechnologies...
  30. ncbi Consent for genetic research in a general population: an update on the National Health and Nutrition Examination Survey experience
    Geraldine M McQuillan
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
    Genet Med 8:354-60. 2006
    ..The study determines the consent rates for storage of biologic samples for future research with and without genetic studies and describes trends in sociodemographic factors associated with consent...
  31. pmc Consent for genetic research in the Framingham Heart Study
    Daniel Levy
    Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MA 01702, USA
    Am J Med Genet A 152:1250-6. 2010
    ..We concluded that the FHS has maintained high rates of retention and consent for genetic research that has provided the scientific freedom to establish collaborations and address a broad range of research ..
  32. ncbi Disclosure of individual genetic data to research participants: the debate reconsidered
    Annelien L Bredenoord
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Department of Medical Ethics, Stratenum 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Trends Genet 27:41-7. 2011
    ..We suggest that the debate should no longer address whether genetic research results should be returned, but instead how best to make an appropriate selection and how to strike a balance ..
  33. ncbi The return of individual research findings in paediatric genetic research
    Kristien Hens
    Katholieke Universiteit Leuven, Centre for Biomedical Ethics and Law, Kapucijnenvoer 35 3 Box 7001, 3000 Leuven, Belgium
    J Med Ethics 37:179-83. 2011
    ..Two dimensions have been distilled from the discussion on return of individual results in a genetic research context: the respect for a participant's autonomy and the duty of the researcher...
  34. ncbi Ethics. Identifiability in genomic research
    William W Lowrance
    Science 317:600-2. 2007
  35. ncbi Undesirable implications of disclosing individual genetic results to research participants
    Leslie A Meltzer
    Georgetown University Law Center, USA
    Am J Bioeth 6:28-30; author reply W10-2. 2006
  36. pmc Public willingness to participate in and public opinions about genetic variation research: a review of the literature
    Rene Sterling
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7240, USA
    Am J Public Health 96:1971-8. 2006
    ..We review empirical studies of public willingness to participate in and opinions about genetic research with particular attention to differences in consent and opinion by racial/ethnic group membership.
  37. ncbi Ethical implications of including children in a large biobank for genetic-epidemiologic research: a qualitative study of public opinion
    David Kaufman
    Genetics and Public Policy Center, Johns Hopkins University, Washington DC, USA
    Am J Med Genet C Semin Med Genet 148:31-9. 2008
    ..To successfully include children, proposed cohort study would need to address children's changing capabilities and rights as they grow and reach the age of consent...
  38. pmc Handling ethical, legal and social issues in birth cohort studies involving genetic research: responses from studies in six countries
    Nola M Ries
    Health Law Institute, Law Centre, University of Alberta, Edmonton, T6G 2H5, Canada
    BMC Med Ethics 11:4. 2010
    ..The growing number of longitudinal, pediatric studies that involve genetic research present even more complex challenges to ensure appropriate protection of children and families as research ..
  39. ncbi Genetic research on stored tissue samples from minors: a systematic review of the ethical literature
    Kristien Hens
    Katholieke Universiteit Leuven, Centre for Biomedical Ethics and Law, Leuven, Belgium
    Am J Med Genet A 149:2346-58. 2009
    The potential benefits of biobank research are well known. Also, the ethical implications of genetic research on stored tissue samples are well discussed in existing literature...
  40. pmc Barriers to translating emerging genetic research on smoking into clinical practice. Perspectives of primary care physicians
    Alexandra E Shields
    Health Policy Institute, Georgetown Public Policy Institute, Georgetown University, Washington, DC 20007, USA
    J Gen Intern Med 20:131-8. 2005
    ..Our objective was to assess primary care physicians' attitudes toward new genetic-based approaches to smoking treatment...
  41. pmc Biological sample collections from minors for genetic research: a systematic review of guidelines and position papers
    Kristien Hens
    Centre for Biomedical Ethics and Law, Leuven, Belgium
    Eur J Hum Genet 17:979-90. 2009
    Stored tissue samples are an important resource for epidemiological genetic research. Genetic research on biological material from minors can yield valuable information on the development and genesis of early-onset genetic disorders and ..
  42. ncbi Distinguishing research from clinical care in cancer genetics: theoretical justifications and practical strategies
    Nina Hallowell
    Department of Public Health Sciences, University of Edinburgh, Edinburgh, UK
    Soc Sci Med 68:2010-7. 2009
    ..Finally, we discuss the implications of these findings for the process of informed consent...
  43. ncbi North-South benefit sharing arrangements in bioprospecting and genetic research: a critical ethical and legal analysis
    Udo Schuklenk
    Centre for Ethics in Public Policy and Corporate Governance, Glasgow Caledonian University, Glasgow, UK
    Dev World Bioeth 6:122-34. 2006
    ..Benefit sharing arrangements for the use of indigenous resources and genetic research could only marginally address this gap in research and development in diseases that affect the poor...
  44. pmc Participant characteristics that influence consent for genetic research in a population-based survey: the Baltimore epidemiologic catchment area follow-up
    Briana Mezuk
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Community Genet 11:171-8. 2008
    ....
  45. ncbi Employees' perspectives on ethically important aspects of genetic research participation: a pilot study
    Laura Weiss Roberts
    Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Compr Psychiatry 46:27-33. 2005
    Insights from genetic research may greatly improve our understanding of physical and mental illnesses and assist in the prevention of disease...
  46. ncbi Research governance, bio-politics and political will: recent lessons from Newfoundland and Labrador
    Daryl Pullman
    Memorial University of Newfoundland, St John s, Canada
    Health Law Rev 13:75-9. 2005
  47. ncbi Ethical issues arising from the participation of children in genetic research
    Wylie Burke
    Department of Medical History and Ethics, University of Washington, Seattle 98195 7120, USA
    J Pediatr 149:S34-8. 2006
    With new tools derived from the Human Genome Project, genetic research is expanding from the study of rare, single gene disorders to the evaluation of genetic contributors to common, complex diseases...
  48. ncbi The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder
    Adam R Aron
    Department of Psychology and Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 57:1285-92. 2005
    ..Moreover, a dissection of response inhibition into more basic components such as rule maintenance, vigilance, and target detection may provide yet better targets for association with genes for neuromodulation and brain development...
  49. pmc Electronic medical records for genetic research: results of the eMERGE consortium
    Abel N Kho
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Sci Transl Med 3:79re1. 2011
    ..Efforts and incentives to increase the implementation of interoperable EMRs will markedly improve the availability of clinical data for genomics research...
  50. pmc Attitudes toward genetic research review: results from a national survey of professionals involved in human subjects protection
    Amy A Lemke
    Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, USA
    J Empir Res Hum Res Ethics 5:83-91. 2010
    ..the views of professionals involved in human subjects protection (HSP) regarding the risks and benefits of genetic research. This anonymous, web-based study elicited the opinions of 208 HSP professionals about review of genetic ..
  51. ncbi Tracing the use and source of racial terminology in representations of genetic research
    Christen Rachul
    Health Law Institute, University of Alberta, Edmonton, Alberta, Canada
    Genet Med 13:314-9. 2011
    We examined the terminology used to describe populations in genetic research to understand how and when terminology is being used, changed, and framed.
  52. pmc Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility
    Christopher A Cassa
    Children s Hospital Informatics Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Genome Res 22:421-8. 2012
    ..Additionally, if the growth rate from the previous 4 yr continues, we estimate that the total number of disease-associated variants will grow 37% over the next 4 yr...
  53. ncbi Incidental findings in genetic research and clinical diagnostic tests: a systematic review
    Leigh Jackson
    School of Nursing and Midwifery, Plymouth University, Plymouth, UK
    Am J Med Genet A 158:3159-67. 2012
    ....
  54. pmc Researcher and institutional review board chair perspectives on incidental findings in genomic research
    Janet K Williams
    College of Nursing, The University of Iowa, Iowa City, Iowa 52242, USA
    Genet Test Mol Biomarkers 16:508-13. 2012
    ..Genomic research can produce findings unrelated to a study's aims. The purpose of this study was to examine researcher and Institutional Review Board (IRB) chair perspectives on genomic incidental findings (GIFs)...
  55. pmc Beliefs and attitudes towards participating in genetic research - a population based cross-sectional study
    Samantha M Kerath
    Feinstein Institute for Medical Research, North Shore LongIsland Jewish Health System, 350 Community Drive, Great Neck, NY 11021, USA
    BMC Public Health 13:114. 2013
    ..To assess the general attitudes towards genetic research and participation in biobanks in the Long Island/Queens area of New York, and what factors would predict a ..
  56. ncbi Quantitative genetic research on sleep: a review of normal sleep, sleep disturbances and associated emotional, behavioural, and health-related difficulties
    Nicola L Barclay
    Northumbria Centre for Sleep Research, Department of Psychology, School of Life Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Sleep Med Rev 17:29-40. 2013
    ....
  57. ncbi Genomic sovereignty and the African promise: mining the African genome for the benefit of Africa
    Jantina de Vries
    Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa
    J Med Ethics 38:474-8. 2012
    ..In this paper, the authors describe these concerns in detail and argue that the concept of genomic sovereignty alone may not be adequate to protect the genetic resources of people of African descent...
  58. ncbi Patients' views on identifiability of samples and informed consent for genetic research
    Sara Chandros Hull
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Am J Bioeth 8:62-70. 2008
    ..used to determine informed consent practices for the use of clinically derived samples for genetic research--is meaningful to patients...
  59. pmc Epilepsy patient-participants and genetic research results as "answers"
    Emily E Namey
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USa enamey gmail com
    J Empir Res Hum Res Ethics 6:21-9. 2011
    ..participating in a genetic study, we found that this population of research subjects anticipated that genetic research results would provide answers to a range of questions about the research process and their condition...
  60. ncbi The storage and use of biological tissue samples from minors for research: a focus group study
    K Hens
    Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven, Leuven, Belgium
    Public Health Genomics 14:68-76. 2011
    b>Genetic research on pediatric stored tissue samples raises specific ethical questions that differ from those raised when adults are the donors. To investigate opinions on this matter, we conducted 10 focus group discussions...
  61. ncbi Great expectations: views of genetic research participants regarding current and future genetic studies
    Gail Henderson
    Department of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7240, USA
    Genet Med 10:193-200. 2008
    Recruitment of prior participants in genetic research is one strategy suggested to maximize efficient use of research dollars in gene-environment studies...
  62. ncbi Next generation sequencing--implications for clinical practice
    Eleanor Raffan
    Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Box 289, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Br Med Bull 99:53-71. 2011
    ..Consequently, many patients with genetic syndromes remain without a specific diagnosis...
  63. pmc Parent perspectives on pediatric genetic research and implications for genotype-driven research recruitment
    Holly K Tabor
    Seattle Children s Research Institute University of Washington, Treuman Katz Center for Pediatric Bioethics, 1900 Ninth Ave, Seattle, WA 98101, USA
    J Empir Res Hum Res Ethics 6:41-52. 2011
    As genetic research is increasingly conducted in children, it is important to understand how parents make decisions about enrolling their children and what they think about receiving their children's genetic research results...
  64. pmc The beliefs, motivations, and expectations of parents who have enrolled their children in a genetic biorepository
    Erin D Harris
    Department of Medicine, Division of Genetics and Program in Genomics, Children s Hospital Boston, Boston, Massachusetts, USA
    Genet Med 14:330-7. 2012
    ..The aim of this study was to understand the views of the parents who enrolled their children in a genomic repository in which IRRs will be returned...
  65. pmc Public and biobank participant attitudes toward genetic research participation and data sharing
    A A Lemke
    Center for Genetic Medicine, Northwestern University, Chicago, Ill 60611, USA
    Public Health Genomics 13:368-77. 2010
    ..study assessed public and biorepository participant attitudes toward research participation and sharing of genetic research data...
  66. ncbi Thresholds and boundaries in the disclosure of individual genetic research results
    Lynn G Dressler
    Case Western Reserve University
    Am J Bioeth 6:18-20; author reply W10-2. 2006
  67. ncbi Human subject protections in genetic research
    M Justin Coffey
    Pritzker School of Medicine, University of Chicago, Chicago, IL 60637
    Genet Test 8:209-13. 2004
    ..In this era of public scrutiny of medical research, we recommend greater familiarity with and documentation of all human subject protections...
  68. ncbi Just around the corner: rhetorics of progress and promise in genetic research
    Robert Evans
    Cardiff School of Social Sciences, UK
    Public Underst Sci 18:43-59. 2009
    ..The effect is a collaborative project in which the promise of a technical solution "just around the corner" is sustained whilst concerns about the future difficulties are marginalized...
  69. pmc The meaning of genetic research results: reflections from individuals with and without a known genetic disorder
    R Jean Cadigan
    Department of Social Medicine, University of North Carolina Chapel Hill, NC 27599 7240, USA
    J Empir Res Hum Res Ethics 6:30-40. 2011
    ....
  70. ncbi Ethical, legal and social issues in the context of the planning stages of the Southern African Human Genome Programme
    Jantina de Vries
    Department of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Med Law 31:119-52. 2012
    ..This article will also consider the present legal framework governing genomic research in South Africa and will conclude with proposals regarding such a framework for the future...
  71. pmc Patient perspectives on group benefits and harms in genetic research
    A J Goldenberg
    Department of Bioethics, Case Western Reserve University, Cleveland, Ohio, USA
    Public Health Genomics 14:135-42. 2011
    It is unclear how the possible effects of genetic research on socially identifiable groups may impact patient willingness to donate biological samples for future genetic studies.
  72. pmc Seeking consent to genetic and genomic research in a rural Ghanaian setting: a qualitative study of the MalariaGEN experience
    Paulina Tindana
    The Ethox Centre, Department of Public Health, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, United Kingdom
    BMC Med Ethics 13:15. 2012
    ..This study sought to identify issues arising in practice during the enrollment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study...
  73. pmc The role of race and trust in tissue/blood donation for genetic research
    Jada Bussey-Jones
    School of Medicine, Emory University, Atlanta, Georgia 30331, USA
    Genet Med 12:116-21. 2010
    Public willingness to donate tissue samples is critical to genetic research. Prior work has linked minority status and mistrust with less willingness to provide specimens...
  74. pmc Opinions and intentions of parents of an autistic child toward genetic research results: two typical profiles
    Laurence Baret
    Department of Social and Preventive Medicine, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada
    Eur J Hum Genet 19:1127-32. 2011
    ..We explored the perspective of parents of an autistic child participating in genetic research. In all, 388 questionnaires were sent to 194 parents; 158 questionnaires were completed (89 mothers and 69 ..
  75. ncbi The future of genetic research on neurodegeneration
    Christine Van Broeckhoven
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Nat Med 16:1215-7. 2010
    ....
  76. ncbi Native Hawaiian preferences for informed consent and disclosure of results from genetic research
    Megan Fong
    Imi Hale Native Hawaiian Cancer Awareness, Research, and Training Network, Program of Papa Ola Lokahi, Honolulu, HI 96813, USA
    J Cancer Educ 21:S47-52. 2006
    ..Informed consent is generally waived when using anonymous stored specimens in research because individual harm is minimal; however, group harm may arise if specimens contain ethnic identifiers...
  77. ncbi Cultural issues in genetic research with American Indian and Alaskan Native people
    Malcolm B Bowekaty
    Governor, A shiwi Zuni Indian Pueblo, USA
    IRB 25:12-5. 2003
  78. ncbi Cultural challenges to biotechnology: Native American genetic resources and the concept of cultural harm
    Rebecca Tsosie
    Indian Legal Program at the Sandra Day O Connor College of Law, Arizona State University, USA
    J Law Med Ethics 35:396-411. 2007
    This article examines the intercultural context of issues related to genetic research on Native peoples...
  79. pmc GWASs and the age of human as the model organism for autoimmune genetic research
    Robert Plenge
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA 02115, USA
    Genome Biol 11:212. 2010
    ..Genetic studies have identified more than 150 autoimmune loci, and next-generation sequencing will identify more. Is it time to make human the model organism for autoimmune research?..
  80. ncbi Study of the involvement of research ethics committees in the constitution and use of biobanks in France
    Gregoire Moutel
    Laboratoire d éthique médicale, de droit de la santé et de santé publique et Institut International de Recherche en Ethique Biomédicale IIREB, Faculté de Médecine Paris Necker, Universite Paris, 5 René Descartes, Paris, France
    Pharmacogenetics 14:195-8. 2004
    Concerns are emerging about the protection of individuals who take part in genetic research involving biobanks...
  81. ncbi Genetic research and biobanks
    Don Chalmers
    Faculty of Law, University of Tasmania, Hobart, TAS, Australia
    Methods Mol Biol 675:1-37. 2011
    Human biobanks, and genetic research databases, as referred to by the Organisation for Economic Co-operation and Development (OECD), are essential tools for modern biomedical research...
  82. pmc Racial and ethnic differences in willingness to participate in psychiatric genetic research
    Eleanor J Murphy
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Psychiatr Genet 19:186-94. 2009
    ..This study was designed to understand some of the barriers to recruitment...
  83. ncbi Genetic research into Alzheimer's disease: a European focus group study on ethical issues
    Anco van der Vorm
    Department of Ethics, Philosophy and History of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Int J Geriatr Psychiatry 23:11-5. 2008
    ..The ethical implications of this kind of research are also attracting attention. However, relatively few open-ended qualitative studies have been carried out to study these aspects...
  84. pmc When research seems like clinical care: a qualitative study of the communication of individual cancer genetic research results
    Fiona A Miller
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
    BMC Med Ethics 9:4. 2008
    ..Empirical data on these questions are limited. Available evidence suggests, on the one hand, growing support for disclosure, and on the other, the potential for significant harm...
  85. ncbi Genomic research and data-mining technology: implications for personal privacy and informed consent
    Herman T Tavani
    Department of Philosophy, Rivier College, Nashua, NH 03060, USA
    Ethics Inf Technol 6:15-28. 2004
    ....
  86. ncbi Ethical and practical challenges surrounding genetic and genomic research in developing countries
    Aceme Nyika
    African Malaria Network Trust AMANET, Dar es Salaam, Tanzania
    Acta Trop 112:S21-31. 2009
    The nature of some potential benefits and risks associated with genetic research is different from the types of potential benefits and risks associated with other types of health research such as clinical trials and biomedical research ..
  87. ncbi Genetics. Genomic research and human subject privacy
    Zhen Lin
    Department of Genetics, Stanford University School of Medicine, CA 94305 5120, USA
    Science 305:183. 2004
  88. ncbi Is it ethical to deny genetic research participants individualised results?
    P Affleck
    Leeds Institute of Molecular Medicine, St James s University Hospital, UK
    J Med Ethics 35:209-13. 2009
    ..genomel.org) and that has relevance to all genetic research in humans...
  89. pmc Understanding incidental findings in the context of genetics and genomics
    Mildred K Cho
    Department of Pediatrics at Stanford University, CA, USA
    J Law Med Ethics 36:280-5, 212. 2008
    ..findings or other findings of clinical significance that arise in the course of human genomic and genetic research. What research results should be offered, and what should not be offered? For which research should ..
  90. ncbi Population genomics and research ethics with socially identifable groups
    Joan L McGregor
    Bioethics, Policy, and Law Program at the School of Life Sciences and Philosophy, Arizona State University, USA
    J Law Med Ethics 35:356-70. 2007
    ..The author argues for a change in the federal guidelines in substance and procedures of conducting genetic research with socially identifiable groups.
  91. ncbi Views of female breast cancer patients who donated biologic samples regarding storage and use of samples for genetic research
    K A Kaphingst
    Center for Community Based Research, Dana Farber Cancer Institute, Boston, MA, USA
    Clin Genet 69:393-8. 2006
    Although social and ethical issues related to the storage and use of biologic specimens for genetic research have been discussed extensively in the medical literature, few empiric data exist describing patients' views...
  92. ncbi Ethical issues in medical-sequencing research: implications of genotype-phenotype studies for individuals and populations
    Morris W Foster
    Department of Anthropology, University of Oklahoma, Norman, OK 73019, USA
    Hum Mol Genet 15:R45-9. 2006
    ..Those issues are reviewed, along with possible solutions to them...
  93. ncbi Warranted concerns, warranted outlooks: a focus group study of public understandings of genetic research
    Benjamin R Bates
    School of Communication Studies, Lasher Hall, Ohio University, Athens, OH 45701, USA
    Soc Sci Med 60:331-44. 2005
    This paper discusses how the American public accounts for the concerns that they have about genetic research and the benefits that they foresee...
  94. ncbi Ethical issues associated with conducting genetic family studies of complex disease
    Nedal H Arar
    Division of Nephrology Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Ann Epidemiol 15:712-9. 2005
    ..To examine subjects' recognition of the risks and ethical issues associated with enrollment in genetic family studies (GFS) and explore how this recognition affects their informed and voluntary participation...
  95. ncbi Associations, populations, and the truth: recommendations for genetic association studies in Arthritis & Rheumatism
    Tom W J Huizinga
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2066-71. 2004
  96. ncbi The debate over research on stored biological samples: what do sources think?
    Dave Wendler
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 162:1457-62. 2002
    ..The debate over informed consent for research on stored biological samples has enormous scientific implications. Unfortunately, there are no data on individuals' attitudes regarding when their consent should be obtained for such research...
  97. ncbi Research on stored biological samples is still research
    Robert M Sade
    Arch Intern Med 162:1439-40. 2002
  98. pmc Offering individual genetic research results: context matters
    Laura M Beskow
    Center for Genome Ethics, Law and Policy, Duke Institute for Genome Sciences and Policy, Durham, NC 27708, USA
    Sci Transl Med 2:38cm20. 2010
    The disclosure of individual genetic research results to study participants continues to be the subject of vigorous debate, centered primarily on the nature of the results...
  99. ncbi Informed consent for population-based research involving genetics
    L M Beskow
    Office of Genetics and Disease Prevention, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, MS K 28, Atlanta, GA 30341 3724, USA
    JAMA 286:2315-21. 2001
    ....
  100. ncbi Genetic research involving human biological materials: a need to tailor current consent forms
    Sara Chandros Hull
    Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    IRB 26:1-7. 2004
  101. pmc The ethics of characterizing difference: guiding principles on using racial categories in human genetics
    Sandra Soo Jin Lee
    Genome Biol 9:404. 2008
    ..We are a multidisciplinary group of Stanford faculty who propose ten principles to guide the use of racial and ethnic categories when characterizing group differences in research into human genetic variation...

Research Grants68

  1. Using Third-Party Data in Pedigree and Subgroup Analyses
    MORRIS FOSTER; Fiscal Year: 2005
    ..of resolving the imperfect fit between biological relatedness and social identity, at least in the case of genetic research and medicine, is to develop approaches for rigorously specifying social identity (i.e...
  2. AFRICAN AMERICAN COMMUNITY REVIEW OF GENETIC RESEARCH
    MORRIS FOSTER; Fiscal Year: 2005
    ..We anticipate that different levels of community review will be applicable to different kinds of local and nested communities. ..
  3. African-American Haplotype Map Engagement and Follow-up
    MORRIS FOSTER; Fiscal Year: 2004
    ..abstract_text> ..
  4. EVALUATING USE OF GENETIC INFORMATION: A MODEL PROCESS
    Wylie Burke; Fiscal Year: 2003
    ..5. To conduct an evaluation of the model process within a large health care system. ..
  5. The ethics of consent for the public release of potentially identifiable DNA data
    Amy McGuire; Fiscal Year: 2009
    ..a consent process that will encourage data sharing while building public trust and fostering participation in genetic research. This project builds on a preliminary study of participants'attitudes toward DNA data release and has ..
  6. Exploring Attitudes About Data Disclosure and Data-Sharing in Genomics Research
    Susanne Haga; Fiscal Year: 2008
    ..The success of large-scale genomics research initiatives will depend on the support and participation of the public and therefore, their views are critically important to obtain. [unreadable] [unreadable] [unreadable]..
  7. NURSING CDROM ON ETHICAL ISSUES OF GENETIC TESTING
    Janet Williams; Fiscal Year: 2002
    ..Increased knowledge of ethical aspects of genetic testing will enable professional nurses to incorporate this knowledge into their professional nursing roles. ..
  8. Family Health After Predictive HD Testing
    Janet Williams; Fiscal Year: 2004
    ..This study will document the health care needs of family members of persons who receive a positive result from presymptomatic gene testing for an inherited degenerative neurologic disease. ..
  9. BEYOND STIGMA--INTERPRETING GENETIC DIFFERENCE
    Pamela Sankar; Fiscal Year: 2003
    ..abstract_text> ..
  10. Smoking Cessation for Head and Neck Cancer Patients
    Robert Schnoll; Fiscal Year: 2006
    ..In turn, our findings may help guide the implementation of smoking cessation treatments for all cancer patients within Comprehensive Cancer Centers in the US. ..
  11. Cultural and Ethical Issues in Genetic Family Studies
    Nedal Arar; Fiscal Year: 2002
    ..2) recruiters' perspective on family enrollment. (3) association of participants' responses with demographic characteristics. (4) ethnic differences in attitudes towards participation in GFS. ..
  12. Advancing the Race Dialog: Genes, Forensics & Medicine
    Pamela Sankar; Fiscal Year: 2006
    ..Our primary aim is to clarify how and why researchers use race and ethnicity in forensic and medical genetic research, and what researchers think are appropriate generalizations and applications of their findings...
  13. EMERGING ISSUES IN CRIMINAL FORENSIC GENETICS
    PAMELA L SANKAR; Fiscal Year: 2010
    ..and effective application of FDP to criminal forensics while maintaining the integrity of contemporary genetic research and continuing to foster public trust in genetic research...
  14. Moral Distress and Suffering of Genetics Professionals
    Gail Geller; Fiscal Year: 2007
    ..Such an intervention would be aimed at renewing commitment to the profession and improving patient care. [unreadable] [unreadable] [unreadable]..
  15. Molecular Epidemiology of Alcoholism 2- Big Sibships
    Andrew Heath; Fiscal Year: 2007
    ..abstract_text> ..
  16. Deep Brain Stimulation for Disorders of Mood Thought and Behavior: Scientific an
    DEBRA MATHEWS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Ethical and Social Issues in the Study of Genetics of Complex Traits
    HOLLY TABOR; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  18. Learning About Research in North Carolina (LeARN)
    Giselle Corbie Smith; Fiscal Year: 2006
    ..studies because of distrust and concerns about the motives of researchers, themes that may be amplified in genetic research. The proposed study, Project LeARN (Learning About Research in North Carolina), will build on a series of ..
  19. Genetic Determinants of Bipolar Disorder
    Jordan Smoller; Fiscal Year: 2007
    ..An important dividend of this large study will be the expansion of the repository to include DNA data on relatives and on an independent sample of controls, thus facilitating future genetic studies. ..
  20. NORTHWEST CANCER GENETICS NETWORK
    Deborah Bowen; Fiscal Year: 2006
    ..This mix of disciplines is essential to support the infrastructure required to collect crucial data on individuals seeking genetic testing, as well as those with known family histories. ..
  21. Comparative Biology of p53, Checkpoint and Longevity
    Gordon Lithgow; Fiscal Year: 2007
    ..As these factors appear to affect aging in both simple invertebrates and mammals, we expect to define broad mechanisms by which cellular and organismal aging are co-regulated. ..
  22. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2008
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  23. Genetic Factors Influencing Warfarin Dose
    Mark Rieder; Fiscal Year: 2008
    ..The long-term aim of this proposal is to account for 100% of the inter-individual variability in warfarin dosing. ..
  24. Ethics and Safeguards in Psychiatric Research
    Laura W Roberts; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Psychiatric genetic research (PGR) holds great promise for preventing, understanding, and treating neuropsychiatric disorders - a source of immense societal burden and personal suffering...
  25. The international 1q type 2 diabetes consortium
    MARK IAN MCCARTHY; Fiscal Year: 2010
    ..This information will contribute to future diagnostic and therapeutic advances in the clinical management of this condition. ..
  26. Prevention of Weight Gain in Young Adults
    Mark Espeland; Fiscal Year: 2009
    ..This approach shows promise for reducing weight gain and thereby improving long-term cardiovascular health. (End of Abstract) ..
  27. Healthy Environments Partnership: Lean & Green in Motown
    Amy Schulz; Fiscal Year: 2009
    ....
  28. Increasing Access to HIV Trials for Rural Minorities
    Giselle Corbie Smith; Fiscal Year: 2009
    ..In Phase 3 we will conduct a single site, 12 month assessment of the individual enrollment session and mobile unit alone and in combination using a 3 arm experimental design. ..
  29. African American Participation in Cancer Genetics Research
    Chanita Hughes Halbert; Fiscal Year: 2009
    ..This study will provide empirical data that can be used to develop more effective strategies for recruiting African Americans to participate in cancer genetics research that enhance decisions about study participation. ..
  30. Government Industry Relationships in Science
    Eric Campbell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. Epigenetic Variation and its Determinants in Depression
    James Potash; Fiscal Year: 2008
    ..Results from the novel studies proposed in this application should shed light on the epigenetic mechanisms and gene-environment interactions that result in vulnerability to depression. ..
  32. Genetic Deafness in the Alumni of Gallaudet University
    Kathleen Arnos; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. GPing: Informatics for Personal Control of Genomic Data
    Isaac S Kohane; Fiscal Year: 2010
    ..3: Design and evaluate a user interface to communicate disclosure. In concert with appropriate non-discrimination legislation, G-PING lays the groundwork for large-scale genomic cohort studies. ..
  34. Mapping HIV/AIDS genes with haplotype-based strategies
    Robert Plenge; Fiscal Year: 2008
    ..These studies hope to identify novel genes that influence susceptibility to HIV/AIDS, thereby providing insight into HIV/AIDS pathogenesis and, ultimately, improving patient care. ..
  35. CONCEPTS OF RACE & ETHNICITY IN GENETICS RESEARCH
    Linda Hunt; Fiscal Year: 2005
    ..In addition to studying research ethics, in order to assure an adequate knowledge base to conduct studies on genetic research, Dr. Hunt will also complete some courses and readings in medical genetics and statistics. Dr...
  36. Index and Retrieval of Pathology Specimens
    Isaac Kohane; Fiscal Year: 2005
    ..abstract_text> ..
  37. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2005
    During the past two decades, genetic research in cardiovascular disease (CVD), as well as other common chronic diseases, has been dominated by single gene linkage and association studies focused on understanding of the genetics of ..
  38. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  39. MHC Loci in the Control of Marek's Lymphoma
    MARCIA MILLER; Fiscal Year: 2005
    ..abstract_text> ..
  40. C. elegans, Aging and High Throughput Screening (RMI)
    Gordon Lithgow; Fiscal Year: 2004
    ..elegans for HTS. Our longer term goal is to undertake HTS for compounds that protect against oxidative stress, extend lifespan and translate into mammalian models of age-related diseases such as Alzheimer's and Parkinson's. ..
  41. NEWBORN GENETIC SCREENING:FOR WHOSE BENEFIT?
    Lainie Ross; Fiscal Year: 2005
    ..OUTCOMES: The major outcomes will be a series of peer-reviewed articles and a full-length book entitled Newborn Genetic Screening: In whose Interest? For whose Benefit? ..
  42. Diaphragm Fatigue:Mechanisms of Treatment by Dopamine
    Janet Pierce; Fiscal Year: 2004
    ..Data obtained from this research will advance our understanding of biological systems, and thus provide data to support clinical trials using dopamine to prevent and treat DF. ..
  43. National Black Leadership Conference on Genetics
    Kathy Hudson; Fiscal Year: 2004
    ..The Conference will be held in Washington DC in May 2004. ..
  44. Psychoneuroimmunology and Cervical Cancer
    Lari Wenzel; Fiscal Year: 2004
    ..All patients will be identified through the Cancer Surveillance Program of Orange, Imperial and San Diego Counties (CSPOC/SanDIOC). ..
  45. SOCIAL AND PHYSICAL ENVIRONMENTS AND HEALTH DISPARITIES
    Amy Schulz; Fiscal Year: 2004
    ....
  46. Weight Gain in African American Breast Cancer Survivors
    Chanita Hughes Halbert; Fiscal Year: 2005
    ..abstract_text> ..
  47. Supporting Decisions In Inherited Cancer Susceptibility
    Mary Ropka; Fiscal Year: 2006
    ....
  48. MOLECULAR MECHANISMS OF HUMAN BLADDER CARCINOGENESIS
    Peter Jones; Fiscal Year: 2006
    ..The participating investigators have a considerable history of collaboration in the areas of translational research in the field of bladder cancer and these interactions will be formalized and enhanced by this Program Project Grant. ..
  49. Linkage Disequilibrium: mapping and positional cloning
    Newton Morton; Fiscal Year: 2006
    ..abstract_text> ..
  50. PSYCHIATRIC RESEARCH ETHICS: SCIENCE AND SAFEGUARDS
    Laura Roberts; Fiscal Year: 2002
    ..Through the plan for development of my research career, I hope to contribute to the advancement of vital, ethically sound research involving mentally ill people and members of other special and potentially vulnerable, populations. ..
  51. GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS
    Sharon Kardia; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  52. INFRASTRUCTURE TO FACILITATE DISCOVERY OF AUTISM GENES
    Joachim Hallmayer; Fiscal Year: 2006
    ..abstract_text> ..
  53. HRT Decision Making in the Post-WHI Era
    Katherine Newton; Fiscal Year: 2006
    ..This study will provide key information about HRT decision making, and experiences with HRT discontinuation, in an era of increased scientific clarity about HRT's risks and benefits. [unreadable] [unreadable]..
  54. DNA repair, genetic variation and skin cancer
    David Hunter; Fiscal Year: 2003
    ..This study will be among the first studies of the association of polymorphisms in candidate DNA repair genes with skin cancer, which assess potential interactions between genotype and sunlight exposure. ..
  55. Race and Public Communication about Human Variation
    Celeste Condit; Fiscal Year: 2003
    ..The project will focus on the concerns of African Americans about discrimination and genetics and on attitudes about African Americans and genetics held by European Americans and the general population. ..
  56. Candidate Genes for Smoking In Related and Unrelated Individuals
    Ovide Pomerleau; Fiscal Year: 2007
    ..abstract not provided ..
  57. Engaging African Communities for the HapMap Project
    Charles Rotimi; Fiscal Year: 2007
    ..abstract_text> ..
  58. Academic Industry Relationships in Genetics
    Eric Campbell; Fiscal Year: 2006
    ..Results will be disseminated through publications in peer-reviewed journals and presentations at scientific meetings. ..
  59. Multi-Dimensional Cultural Values
    Chanita Hughes Halbert; Fiscal Year: 2009
    ..This study will provide a psychometrically sound instrument that can be used in clinical and research settings to provide culturally sensitive care and interventions to ethnically and racially diverse populations. ..
  60. Effects of family smoking history in never-smokers
    Ovide Pomerleau; Fiscal Year: 2006
    ....
  61. Indian and Hindu Perspectives on Genetic Variation
    John Belmont; Fiscal Year: 2006
    ..will engage members of Indian communities in the Houston metropolitan area to elicit their perspectives on genetic research and the International HapMap Project...
  62. Folate, 1-Carbon Nutrients, Gene Variants & Colon Cancer
    David Hunter; Fiscal Year: 2008
    ..These highly interrelated studies will help integrate epidemiologic and mechanistic observations and help provide a basis for public health recommendations on optimal levels of folate and B vitamin intake. ..
  63. Mitochondrial Genetics of Recovery After Brain Injury
    Yvette Conley; Fiscal Year: 2008
    ....
  64. Lifespan determination and stress response in C. elegans
    Gordon Lithgow; Fiscal Year: 2006
    ..Thirdly, we will identify and manipulate the levels of endocrine signals that act downstream of the insulin/IGF signaling pathway to limit lifespan. ..
  65. STUDIES OF GENOMIC IMPRINTING IN BIPOLAR DISORDER
    James Potash; Fiscal Year: 2005
    ....
  66. DOUCHING, VAGINAL MICROBIOLOGY, AND PID
    Roberta Ness; Fiscal Year: 2003
    ..Given the paucity of information regarding the relationship between douching and reproductive outcomes, the proposed study is imperative in order to direct future public health recommendations. ..