Summary: The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)

Top Publications

  1. ncbi The impact of next-generation sequencing technology on genetics
    Elaine R Mardis
    Genome Sequencing Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Trends Genet 24:133-41. 2008
  2. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
  3. ncbi Genomics and the future of conservation genetics
    Fred W Allendorf
    University of Montana, Missoula, 59812, USA
    Nat Rev Genet 11:697-709. 2010
  4. ncbi simuPOP: a forward-time population genetics simulation environment
    Bo Peng
    Department of Statistics, Rice University, Houston, TX 77005, USA
    Bioinformatics 21:3686-7. 2005
  5. pmc SoyBase, the USDA-ARS soybean genetics and genomics database
    David Grant
    USDA ARS CICGRU, Department of Agronomy, Iowa State University, Ames, IA 50011, USA
    Nucleic Acids Res 38:D843-6. 2010
  6. pmc The Genetics Concept Assessment: a new concept inventory for gauging student understanding of genetics
    Michelle K Smith
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    CBE Life Sci Educ 7:422-30. 2008
  7. ncbi The Fungal Genetics Stock Center: a repository for 50 years of fungal genetics research
    K McCluskey
    School of Biological Sciences, University of Missouri Kansas City, 5007 Rockhill Road, Kansas City, Missouri 64110, USA
    J Biosci 35:119-26. 2010
  8. ncbi Putting the "landscape" in landscape genetics
    A Storfer
    School of Biological Sciences, Washington State University, Pullman, WA, USA
    Heredity 98:128-42. 2007
  9. pmc The genetics of attention deficit/hyperactivity disorder in adults, a review
    B Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 17:960-87. 2012
  10. pmc Using the Genetics Concept Assessment to document persistent conceptual difficulties in undergraduate genetics courses
    Michelle K Smith
    School of Biology and Ecology and the Center for Research in Science, Technology, Engineering, and Math Education, University of Maine, Orono, Maine 04469, USA
    Genetics 191:21-32. 2012

Research Grants

Detail Information

Publications246 found, 100 shown here

  1. ncbi The impact of next-generation sequencing technology on genetics
    Elaine R Mardis
    Genome Sequencing Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Trends Genet 24:133-41. 2008
    If one accepts that the fundamental pursuit of genetics is to determine the genotypes that explain phenotypes, the meteoric increase of DNA sequence information applied toward that pursuit has nowhere to go but up...
  2. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  3. ncbi Genomics and the future of conservation genetics
    Fred W Allendorf
    University of Montana, Missoula, 59812, USA
    Nat Rev Genet 11:697-709. 2010
    ..Now is a crucial time to explore the potential implications of this information revolution for conservation genetics and to recognize limitations in applying genomic tools to conservation issues...
  4. ncbi simuPOP: a forward-time population genetics simulation environment
    Bo Peng
    Department of Statistics, Rice University, Houston, TX 77005, USA
    Bioinformatics 21:3686-7. 2005
    simuPOP is a forward-time population genetics simulation environment...
  5. pmc SoyBase, the USDA-ARS soybean genetics and genomics database
    David Grant
    USDA ARS CICGRU, Department of Agronomy, Iowa State University, Ames, IA 50011, USA
    Nucleic Acids Res 38:D843-6. 2010
    SoyBase, the USDA-ARS soybean genetic database, is a comprehensive repository for professionally curated genetics, genomics and related data resources for soybean...
  6. pmc The Genetics Concept Assessment: a new concept inventory for gauging student understanding of genetics
    Michelle K Smith
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    CBE Life Sci Educ 7:422-30. 2008
    We have designed, developed, and validated a 25-question Genetics Concept Assessment (GCA) to test achievement of nine broad learning goals in majors and nonmajors undergraduate genetics courses...
  7. ncbi The Fungal Genetics Stock Center: a repository for 50 years of fungal genetics research
    K McCluskey
    School of Biological Sciences, University of Missouri Kansas City, 5007 Rockhill Road, Kansas City, Missouri 64110, USA
    J Biosci 35:119-26. 2010
    The Fungal Genetics Stock Center (FGSC) was established in 1960 to ensure that important strains used in early genetics research were available to subsequent generations of fungal geneticists. Originally, only mutant strains were held...
  8. ncbi Putting the "landscape" in landscape genetics
    A Storfer
    School of Biological Sciences, Washington State University, Pullman, WA, USA
    Heredity 98:128-42. 2007
    Landscape genetics has emerged as a new research area that integrates population genetics, landscape ecology and spatial statistics...
  9. pmc The genetics of attention deficit/hyperactivity disorder in adults, a review
    B Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 17:960-87. 2012
    ..Progress in identifying aADHD risk genes may provide us with tools for the prediction of disease progression in the clinic and better treatment, and ultimately may help to prevent persistence of ADHD into adulthood...
  10. pmc Using the Genetics Concept Assessment to document persistent conceptual difficulties in undergraduate genetics courses
    Michelle K Smith
    School of Biology and Ecology and the Center for Research in Science, Technology, Engineering, and Math Education, University of Maine, Orono, Maine 04469, USA
    Genetics 191:21-32. 2012
    To help genetics instructors become aware of fundamental concepts that are persistently difficult for students, we have analyzed the evolution of student responses to multiple-choice questions from the Genetics Concept Assessment...
  11. ncbi The developmental genetics of homology
    Gunter P Wagner
    Department of Ecology and Evolutionary Biology, Yale University, POB 208106, New Haven, Connecticut 06520 8106, USA
    Nat Rev Genet 8:473-9. 2007
    ..These networks, here referred to as 'character identity networks', enable the execution of a character-specific developmental programme...
  12. pmc Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29
    Ming Chang Chiang
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
    Neuroimage 54:2308-17. 2011
    ..Genes affect fiber integrity, but their effects vary with age, sex, SES and IQ. Gene-environment interactions are vital to consider in the search for specific genetic polymorphisms that affect brain integrity and connectivity...
  13. pmc Culturally relevant inquiry-based laboratory module implementations in upper-division genetics and cell biology teaching laboratories
    Dimuth Siritunga
    Department of Biology, University of Puerto Rico, Mayaguez
    CBE Life Sci Educ 10:287-97. 2011
    ..Laboratory modules were implemented in upper-division genetics and cell biology courses using cassava as the central theme...
  14. pmc Darwin and genetics
    Brian Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh EH9 3JT, United Kingdom
    Genetics 183:757-66. 2009
    ..We review the interaction between evolution and genetics, showing how, unlike Mendel, Darwin's lack of a model of the mechanism of inheritance left him unable to ..
  15. ncbi Bioinformatics for human genetics: promises and challenges
    Annika Lindblom
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Hum Mutat 32:495-500. 2011 (IT) systems and electronic health records, amass ever-increasing amounts of data before human genetics scientists and clinicians...
  16. pmc Notch and the awesome power of genetics
    Iva Greenwald
    Department of Biochemistry and Molecular Biophysics, Department of Genetics and Development, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genetics 191:655-69. 2012
    ..As an essay for the GENETICS Perspectives series, it is my personal and critical commentary as well as an historical account of discovery.
  17. pmc Ten years of genetics and genomics: what have we achieved and where are we heading?
    Edith Heard
    INSERM U CNRS UMR, Institut Curie Centre de Recherche, Paris, France
    Nat Rev Genet 11:723-33. 2010
    To celebrate the first 10 years of Nature Reviews Genetics, we asked eight leading researchers for their views on the key developments in genetics and genomics in the past decade and the prospects for the future...
  18. pmc Speciation genetics: current status and evolving approaches
    Jochen B W Wolf
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, 75236 Uppsala, Sweden
    Philos Trans R Soc Lond B Biol Sci 365:1717-33. 2010
    ..This review aims at providing an extensive overview of speciation genetics. Starting from key historical developments and core concepts of speciation genetics, we focus much of our ..
  19. ncbi PhenX: a toolkit for interdisciplinary genetics research
    Patrick J Stover
    Cornell University, Ithaca, New York, USA
    Curr Opin Lipidol 21:136-40. 2010
    ..measures for Phenotypes and eXposures) measures for nutrition, dietary supplements, and cardiovascular disease research and to demonstrate how these and other PhenX measures can be used to further interdisciplinary genetics research.
  20. pmc The gene balance hypothesis: from classical genetics to modern genomics
    James A Birchler
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Plant Cell 19:395-402. 2007
  21. pmc Instructors' practices in and attitudes toward teaching ethics in the genetics classroom
    Joan M Booth
    Department of Biology, Hamilton College, Clinton, New York 13323, USA
    Genetics 168:1111-7. 2004 of undergraduate biology students in the United States, we surveyed instructors of introductory genetics. We found that there was support for more ethics education both in the general curriculum and in the genetics ..
  22. ncbi An integrative view of phylogenetic comparative methods: connections to population genetics, community ecology, and paleobiology
    Matthew W Pennell
    Department of Biological Sciences and Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, Idaho, USA
    Ann N Y Acad Sci 1289:90-105. 2013
    ..across fields and focus on three examples where such integration might be particularly valuable: quantitative genetics, community ecology, and paleobiology...
  23. ncbi Opening Darwin's black box: teaching evolution through developmental genetics
    Scott F Gilbert
    Swarthmore College, Swarthmore, Pennsylvania 19081, USA
    Nat Rev Genet 4:735-41. 2003
    ..This perspective presents some of this new evidence and provides a framework in which to explain homology and phylogeny to such audiences...
  24. pmc Genetics of drug dependence
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Dialogues Clin Neurosci 12:77-84. 2010
    ..Although considerable progress has been made, it is likely that the application of more extensive sequencing than has previously been practical will be required to identify a fuller range of risk variants...
  25. ncbi Next-generation education in crop genetics
    Eyal Fridman
    The RH Smith Institute of Plant Science and Genetics in Agriculture, The RH Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Curr Opin Plant Biol 15:218-23. 2012
    ..We discuss the need, opportunities and conflicts associated with revamping plant breeding teaching programs to bridge the art and science of this profession with a rapidly expanding job market...
  26. ncbi Biofantasies: genetics and medicine in the print news media
    A Petersen
    Sociology Programme School of Social Inquiry, Murdoch University, Western Australia, Australia
    Soc Sci Med 52:1255-68. 2001
    The contemporary news media is an important site for exploring the diverse and complex cultural images of genetics and its medical possibilities, and of the mechanisms by which these images are (re) produced and sustained...
  27. ncbi Risk in complex genetics: "all models are wrong but some are useful"
    Stephen Sawcer
    Department of Clinical Neuroscience, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Ann Neurol 72:502-9. 2012
  28. ncbi A review of developmental instability, parasitism and disease. Infection, genetics and evolution
    Anders Pape Møller
    Laboratoire de Parasitologie Evolutive, CNRS UMR 7103, Universite Pierre et Marie Curie, Bat A, 7eme etage, 7 quai St Bernard, Case 237, F 75252 Paris Cedex 05, France
    Infect Genet Evol 6:133-40. 2006
    ..These findings may have important implications for the study of susceptibility of hosts to infectious disease...
  29. ncbi Genetics education in the nursing profession: literature review
    Sarah Burke
    Centre for Research in Medical and Dental Education, University of Birmingham, Birmingham, UK
    J Adv Nurs 54:228-37. 2006
    This paper reports a literature review exploring genetics education for nursing professionals. The aim was to contribute to the debate about the future direction of such education.
  30. ncbi Historical and modern genetics of plant graft hybridization
    Yongsheng Liu
    Department of Horticulture, Henan Institute of Science and Technology, Xinxiang 453003, China
    Adv Genet 56:101-29. 2006
  31. pmc Genetic educational needs and the role of genetics in primary care: a focus group study with multiple perspectives
    Elisa Jf Houwink
    Department of Clinical Genetics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    BMC Fam Pract 12:5. 2011
    Available evidence suggests that improvements in genetics education are needed to prepare primary care providers for the impact of ongoing rapid advances in genomics...
  32. ncbi The genetics of eating disorders
    Sietske G Helder
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Denmark Hill, London, SE5 8AF, UK
    Curr Top Behav Neurosci 6:157-75. 2011
    ..More recently, with the advent of genome-wide association studies (GWAS), analysis with microsatellite markers has implicated novel candidate loci for AN at 1q41 and 11q22, and further GWAS results are expected in the near future...
  33. ncbi Public understandings of genetics and health
    C M Condit
    Department of Speech Communication, Terrell Hall, University of Georgia, Athens, GA, USA
    Clin Genet 77:1-9. 2010
    This review of adult public understandings of genetics related to health indicates that the public's understandings overlap with those of professionals in some areas, but not others...
  34. pmc A proposal for a uniform nomenclature in bacterial genetics
    M Demerec
    Genetics 54:61-76. 1966
  35. pmc Ernst Mayr: Genetics and speciation
    William B Provine
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 167:1041-6. 2004
  36. ncbi Habituation in rodents: a review of behavior, neurobiology, and genetics
    Melanie P Leussis
    Laboratory of Developmental Neuropharmacology, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 30:1045-64. 2006
  37. ncbi Genes, genetics, and epigenetics: a correspondence
    J R Morris
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 293:1103-5. 2001
    ..Bacon. These queries concern the popular definitions of "genes," "genetics," and "epigenetics...
  38. ncbi Deficiency of knowledge of genetics and genetic tests among general practitioners, gynecologists, and pediatricians: a global problem
    Marieke J H Baars
    Department of Clinical Genetics and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
    Genet Med 7:605-10. 2005
    The objective of this study was to assess knowledge of genetics and awareness of genetic tests among Dutch general practitioners (GPs), gynecologists (GYNs), and pediatricians (PEDs), as well as factors influencing their knowledge and ..
  39. pmc Imaging or imagining? A neuroethics challenge informed by genetics
    Judy Illes
    Stanford University, USA
    Am J Bioeth 5:5-18. 2005
    ..Some issues, akin to those surrounding modern genetics, raise critical questions regarding prediction of disease, privacy and identity...
  40. ncbi Advances in asthma, allergy mechanisms, and genetics in 2006
    Fred D Finkelman
    Division of Immunology, University of Cincinnati, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 120:544-50. 2007
    This review discusses the main advances in animal models of allergic airway disease and genetics of asthma and allergy published in the Journal in 2006...
  41. pmc One hundred years of mouse genetics: an intellectual history. I. The classical period (1902-1980)
    Kenneth Paigen
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Genetics 163:1-7. 2003
  42. pmc The role of phylogenetics in comparative genetics
    Douglas E Soltis
    Department of Botany and the Genetics Institute, University of Florida, Gainesville, Florida 32611, USA
    Plant Physiol 132:1790-800. 2003
  43. pmc Development and evaluation of a genetics literacy assessment instrument for undergraduates
    Bethany Vice Bowling
    Interdisciplinary Studies Program, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Genetics 178:15-22. 2008
    There is continued emphasis on increasing and improving genetics education for grades K-12, for medical professionals, and for the general public...
  44. ncbi A century after Fisher: time for a new paradigm in quantitative genetics
    Ronald M Nelson
    Swedish University of Agricultural Sciences, Department of Clinical Sciences, Division of Computational Genetics, Box 7078, SE 750 07 Uppsala, Sweden Electronic address
    Trends Genet 29:669-76. 2013
    Quantitative genetics traces its roots back through more than a century of theory, largely formed in the absence of directly observable genotype data, and has remained essentially unchanged for decades...
  45. ncbi Nurses' competence in genetics: a mixed method systematic review
    Heather Skirton
    Applied Health Genetics, School of Nursing and Midwifery, Faculty of Health, Education and Society, Plymouth University, Taunton, Somerset, UK
    J Adv Nurs 68:2387-98. 2012
    To ascertain the extent to which nurses are achieving the core competences in genetics appropriate for nursing practice.
  46. ncbi Biological invasions in agricultural settings: insights from evolutionary biology and population genetics
    Thomas Guillemaud
    Equipe Biologie des Populations en Interaction, UMR 1301 IBSV INRA CNRS, Universite de Nice Sophia Antipolis, 400 Route des Chappes, Sophia Antipolis Cedex, France
    C R Biol 334:237-46. 2011
    ..In this article we suggest that the reconstruction of invasion routes with population genetics-based methods can address fundamental questions in ecology and practical aspects of the management of biological ..
  47. pmc Key questions in the genetics and genomics of eco-evolutionary dynamics
    A P Hendry
    Redpath Museum, Department of Biology, McGill University, Montreal, Quebec, Canada
    Heredity (Edinb) 111:456-66. 2013
    ..The genetics and genomics of these 'eco-evolutionary dynamics' will be--to a large extent--the genetics and genomics of ..
  48. ncbi The transformation of the model organism: a decade of developmental genetics
    Kathryn V Anderson
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Genet 33:285-93. 2003
    ..Vertebrate developmental genetics is now flourishing, with forward and reverse genetics in both zebrafish and the mouse providing new dimensions to ..
  49. pmc Sex, gender, genetics, and health
    Susan E Short
    Susan E Short is with the Department of Sociology and the Population Studies Training Center, Brown University, Providence, RI Yang Claire Yang is with the Department of Sociology, Lineberger Comprehensive Cancer Center, and Carolina Population Center at the University of North Carolina Chapel Hill Tania M Jenkins is with the Department of Sociology, Brown University
    Am J Public Health 103:S93-101. 2013
    This article addresses 2 questions. First, to what extent are sex and gender incorporated into research on genetics and health? Second, how might social science understandings of sex and gender, and gender differences in health, become ..
  50. ncbi What does 'respect for persons' require? Attitudes and reported practices of genetics researchers in informing research participants about research
    Fiona Alice Miller
    Department of Health Policy, Management and Evaluation, University of Toronto, 155 College Street, Toronto, Ontario, Canada
    J Med Ethics 38:48-52. 2012
    ..Yet little research explores researchers' attitudes and practices regarding the range of initiatives that might serve these ends...
  51. pmc Establishing the outcome indicators for the essential nursing competencies and curricula guidelines for genetics and genomics
    Kathleen A Calzone
    National Institutes of Health, National Cancer Institute, Center for Cancer Research, Genetics Branch, Bethesda, MD 20889 5150, USA
    J Prof Nurs 27:179-91. 2011
    The translation of genetics/genomics to clinical care has implications for nurses. The Essential Nursing Competencies and Curricula Guidelines for Genetics and Genomics, established by consensus, apply to all registered nurses...
  52. pmc Genetics of emotion
    Laura Bevilacqua
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    Trends Cogn Sci 15:401-8. 2011
    ..The effects of these genes can be validated by neuroimaging, neuroendocrine and other studies accessing intermediate phenotypes, deepening our understanding of mechanisms of emotion and variation in emotionality...
  53. pmc Characteristics of genetics-related news content in Black weekly newspapers
    C A Caburnay
    Health Communication Research Laboratory, Brown School of Social Work, Washington University in St Louis, MO, USA
    Public Health Genomics 17:7-15. 2014
    ..This study characterized media coverage of genetics-related information in Black weekly newspapers and general audience newspapers from the same communities.
  54. ncbi Small flies--big discoveries: nearly a century of Drosophila genetics and development
    Anthea Letsou
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, USA
    Dev Dyn 232:526-8. 2005
  55. ncbi Ethical guidelines in genetics and genomics. An Islamic perspective
    Aida I Al-Aqeel
    Department of Pediatrics, Armed Forces Hospital, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia
    Saudi Med J 26:1862-70. 2005
    ..A World Health Organization expert consultation concluded that "genetics advances will only be acceptable if their application is carried out ethically, with due regard to autonomy, ..
  56. ncbi Enhancing exposure to genetics and genomics through an innovative medical school curriculum
    Shweta U Dhar
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genet Med 14:163-7. 2012
    Physicians entering medical practice in the 21st century will require more than a basic understanding of human genetics because of rapid progress in the field of genetics and genomics...
  57. ncbi Bayesian statistics in genetics: a guide for the uninitiated
    J S Shoemaker
    The Cancer Prevention, Detection, Control Research Program, Duke Medical Center, Box 2949, Durham, NC 27710, USA
    Trends Genet 15:354-8. 1999
  58. ncbi Long-term outcomes of the "Genetics in Primary Care" faculty development initiative
    Anne Marie Laberge
    Medical Genetics Division, Department of Pediatrics, CHU Sainte Justine, Université Montréal, Montreal, Quebec, Canada
    Fam Med 41:266-70. 2009
    Between October 2000 and April 2001, 79 primary care physicians (PCPs) and 21 genetics professionals from 20 teaching medical universities across the United States participated in the Genetics in Primary Care (GPC) project (a national ..
  59. pmc Teaching biology through statistics: application of statistical methods in genetics and zoology courses
    Department of Biology, University of Puerto Rico, San Juan
    CBE Life Sci Educ 10:259-67. 2011
    ..prerequisites to core science courses, and incorporating interdisciplinary (math-biology) learning activities in genetics and zoology courses...
  60. ncbi The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics
    Oscar Lao
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Ann Hum Genet 72:48-56. 2008
  61. ncbi Genetics of mammalian reproduction: modeling the end of the germline
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Physiol 74:503-28. 2012
    ..Finally, we reflect on the future of reproductive biology: how advances in clinical genetics will provide special opportunities to understand which reproductive processes are affected by genetic lesions and ..
  62. ncbi Did Paul Kammerer discover epigenetic inheritance? No and why not
    Sander Gliboff
    Department of History and Philosophy of Science, Indiana University, 1011 E 3rd St, Bloomington, IN 47405, USA
    J Exp Zool B Mol Dev Evol 314:616-24. 2010
  63. pmc D. S. Falconer and Introduction to quantitative genetics
    William G Hill
    School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 167:1529-36. 2004
  64. pmc A comprehensive analysis of high school genetics standards: are states keeping pace with modern genetics?
    M J Dougherty
    American Society of Human Genetics, Bethesda, MD 20814, USA
    CBE Life Sci Educ 10:318-27. 2011 teaching and learning, we investigated the quality of life sciences/biology standards with respect to genetics for all 50 states and the District of Columbia, using core concepts developed by the American Society of Human ..
  65. pmc Essay contest reveals misconceptions of high school students in genetics content
    Kenna R Mills Shaw
    American Society of Human Genetics, Bethesda, Maryland 20814, USA
    Genetics 178:1157-68. 2008
    ..In this case, scientists from the American Society of Human Genetics (ASHG), the Genetics Society of America (GSA), and the National Society of Genetic Counselors (NSGC) have ..
  66. ncbi Using the PRACTICE mnemonic to apply cultural competency to genetics in medical education and patient care
    P Preston Reynolds
    Primary Care Medical Education Branch, Division of Medicine and Dentistry, Health Resources and Services Administration NIH, 5600 Fishers Lane, Parklawn Bldg, Rm 9A 20, Rockville, MD 20857, USA
    Acad Med 80:1107-13. 2005
    ..competency and skills development in working with ethnically diverse patient populations as well as courses on genetics and genomics...
  67. pmc The developmental genetics of apterous mutants of Drosophila melanogaster
    F M Butterworth
    Genetics 52:1153-74. 1965
  68. ncbi Managing partnerships and impact on decision-making: the example of health technology assessment in genetics
    Ingeborg Blancquaert
    Agence d évaluation des technologies et des modes d intervention en santé, Montreal, Canada
    Community Genet 9:27-33. 2006
    For an emerging field such as Public Health Genetics, the partnerships that will be developed with stakeholders are of strategic importance, since they may affect long-term impact on policy-making...
  69. ncbi Educating health-care professionals about genetics and genomics
    Alan E Guttmacher
    National Human Genome Research Institute, Building 31, Room 4B09, Bethesda, MD 20892 2152, USA
    Nat Rev Genet 8:151-7. 2007
    To biomedical researchers, this is the 'genome era'. Advances in genetics and genomics such as the sequence of the human genome, the human haplotype map, open access databases, cheaper genotyping and chemical genomics have already ..
  70. pmc Information extraction from full text scientific articles: where are the keywords?
    Parantu K Shah
    Biocomputing, European Molecular Biology Laboratory, Heidelberg, Germany
    BMC Bioinformatics 4:20. 2003
    ..Several questions arise as to whether the effort of scanning full text articles is worthy, or whether the information that can be extracted from the different sections of an article can be relevant...
  71. ncbi Mainstreaming genetics: a comparative review of clinical services for inherited cardiovascular conditions in the UK
    Hilary Burton
    Foundation for Genomics and Population Health, Cambridge, UK
    Public Health Genomics 13:235-45. 2010
    ..Services should be led by cardiology but have close links with clinical genetics services, which should provide support with specialist genetics advice and cascade testing...
  72. ncbi Resources and strategies to integrate the study of ethical, legal, and social implications of genetics into the undergraduate curriculum
    Jinnie M Garrett
    Department of Biology, Hamilton College, Clinton, New York, NY, USA
    Adv Genet 66:35-59. 2009 individual's genetic information are just a few of the developments emerging from recent advances in molecular genetics that are controversial...
  73. ncbi The future of fMRI and genetics research
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Neuroimage 62:1286-92. 2012
    I provide a brief and subjective view of where the field of imaging genetics is heading...
  74. ncbi Genetics of familial amyotrophic lateral sclerosis
    Paul N Valdmanis
    Center for the Study of Brain Diseases, University of Montreal, CHUM Research Center Notre Dame Hospital, J A de Sève Pavilion, Room Y 3633, 1560, Sherbrooke St East, Montreal, QC, Canada
    Neurology 70:144-52. 2008
    ..The challenge now lies in determining which models are the most appropriate to dissect out the genetic components involved. This research will ultimately aid in identifying the cumulative risk of developing ALS...
  75. pmc Drosophila genetics in the classroom
    W Sofer
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 0759
    Genetics 136:417-22. 1994
    Drosophila has long been useful for demonstrating the principles of classical Mendelian genetics in the classroom. In recent years, the organism has also helped students understand biochemical and behavioral genetics...
  76. pmc Myriad Genetics: In the eye of the policy storm
    E Richard Gold
    McGill Faculty of Law, McGill University, 3644 Peel Street, Montreal, Quebec, Canada
    Genet Med 12:S39-70. 2010
    ..Myriad Genetics, Inc., along with its subsidiary, Myriad Genetic Laboratories, Inc...
  77. ncbi Genetics of human brain oscillations
    Henri Begleiter
    Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Int J Psychophysiol 60:162-71. 2006
    ..It is concluded that the advent of genomics and proteomics and a fuller understanding of gene regulation will open new horizons on the critical electrical events so essential for human brain function...
  78. ncbi Leptin and the onset of puberty: insights from rodent and human genetics
    I Sadaf Farooqi
    University Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Semin Reprod Med 20:139-44. 2002
    ..This work suggests that leptin is a metabolic gate for the onset of puberty in humans. Leptin's actions may be mediated by central pathways and by direct action on peripheral organs...
  79. pmc Incorporating a new bioinformatics component into genetics at a historically black college: outcomes and lessons
    J David Holtzclaw
    School of Medicine, Emory University, Atlanta, GA 30322, USA
    CBE Life Sci Educ 5:52-64. 2006
    ..To change this, we designed and implemented a new bioinformatics component to supplement the undergraduate Genetics course at Clark Atlanta University. The outcomes of the Bioinformatics course were assessed...
  80. ncbi [Serotonin now: Part 1. Neurobiology and developmental genetics]
    C Kriegebaum
    Klinik fur Psychiatrie, Psychosomatik und Psychotherapie, Universitat Wurzburg
    Fortschr Neurol Psychiatr 78:319-31. 2010
  81. pmc Tragic history of the VII International Congress of Genetics
    Valery N Soyfer
    George Mason University, Fairfax, Virginia 22030, USA
    Genetics 165:1-9. 2003
  82. pmc Genetics in schizophrenia: where are we and what next?
    Arun K Tiwari
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Dialogues Clin Neurosci 12:289-303. 2010
    ..In this review we summarize the major findings of the past decade and suggest areas of future research...
  83. ncbi Opportunity knocks: the pathologist as laboratory genetics consultant
    Roger D Klein
    Arch Pathol Lab Med 130:1603-4. 2006
  84. ncbi Hybrids, pure cultures, and pure lines: from nineteenth-century biology to twentieth-century genetics
    Staffan Müller-Wille
    ESRC Research Centre for Genomics in Society, University of Exeter, Exeter EX4 4PJ, UK
    Stud Hist Philos Biol Biomed Sci 38:796-806. 2007
    ..endorsed by 'biology' when it came into being around 1800 and was brought to full fruition with the emergence of genetics in 1900...
  85. ncbi Studying the genetics of Hirschsprung's disease: unraveling an oligogenic disorder
    A S Brooks
    Department of Clinical Genetics, Erasmus MC, Rotterdam
    Clin Genet 67:6-14. 2005
    ..Finally, we speculate on possible strategies to identify new genes for Hirschsprung's disease...
  86. ncbi Recent advances in the genetics of amyotrophic lateral sclerosis
    Paul N Valdmanis
    Center of Excellence in Neuromics of the CHUMResearch Center and the Department of Medicine, University of Montreal, 1560 Sherbrooke Street East, Room Y 3633, Montreal QCH2L4M1, Canada
    Curr Neurol Neurosci Rep 9:198-205. 2009
    ..The findings help to better delineate the types of genes and genetic variants that are involved in ALS and provide substantial material for future research...
  87. pmc SYSGENET: a meeting report from a new European network for systems genetics
    Klaus Schughart
    Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Mamm Genome 21:331-6. 2010
    ..About 50 researchers working in the field of systems genetics using mouse genetic reference populations (GRP) participated in the meeting and exchanged their results, ..
  88. ncbi Genetics of cholesterol and lipoprotein metabolism
    Mark E Samuels
    Centre de Recherche du CHUM, Universite de Montreal, Hopital Notre Dame, 1560, rue Sherbrooke Est, Local M 5226, Montreal, QC H2L 4M1, Canada
    Recent Pat Cardiovasc Drug Discov 2:195-204. 2007
    ..In practice, genetics provides a unique opportunity to observe the behavior of whole systems in the presence of different amounts of a ..
  89. ncbi Pediatric psychology training and genetics: what will twenty-first-century pediatric psychologists need to know?
    Andrea Farkas Patenaude
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Pediatr Psychol 28:135-45. 2003
    ..To demonstrate the importance of genetic knowledge in coming decades and to outline necessary areas of genetic education...
  90. ncbi Translating genetics, cognitive science, and other basic science research findings into applications for prevention
    Susan L Ames
    The Institute for Health Promotion and Disease Prevention Research, University of Southern California, Los Angeles 91803, USA
    Eval Health Prof 29:277-301. 2006
    A growing body of research across genetics, cognitive science, and other basic science suggests the complexity and interconnectedness of multiple factors contributing to individual variation in susceptibility to engage in risk behaviors...
  91. ncbi Parkinson's disease genetics: a complex disease comes to the clinic
    Jordi Perez-Tur
    Lancet Neurol 5:896-7. 2006
  92. ncbi The X chromosome and the female survival advantage: an example of the intersection between genetics, epidemiology and demography
    K Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, and the Danish Center for Demographic Research, University of Southern Denmark, Odense
    Ann N Y Acad Sci 954:175-83. 2001
    Despite differences in research traditions, the disciplines of genetics, epidemiology, and demography are becoming increasingly integrated in health-related research...
  93. pmc Learning the common language of genetics
    Allan C Spradling
    Department of Embryology, Carnegie Institution of Washington HHMI, Baltimore, MD 21218, USA
    Genetics 174:1-3. 2006
  94. ncbi What is 'public opinion' about genetics?
    C Condit
    Department of Speech Communication, University of Georgia, 110 Terrell Hall, Athens, Georgia 30602, USA
    Nat Rev Genet 2:811-5. 2001
    Every biotechnology success story increases the number of decisions that the lay public must make about genetics. But vibrant public discussion about these far-reaching changes has been rare, and research on the public's understanding of ..
  95. pmc Closing the gap: inverting the genetics curriculum to ensure an informed public
    Michael J Dougherty
    ASHG, 9650 Rockville Pike, Bethesda, MD 20814, USA
    Am J Hum Genet 85:6-12. 2009
    ..This underperformance is true for genetics, as well as for science and math in general, and is particularly worrisome given the accelerating need for ..
  96. pmc Integrating computational biology and forward genetics in Drosophila
    Stein Aerts
    Department of Molecular and Developmental Genetics, Laboratory of Neurogenetics, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    PLoS Genet 5:e1000351. 2009
    ..However, a systems biology approach to genetics must leverage the massive amount of "omics" data to enhance the power and speed of functional gene discovery in ..
  97. ncbi Genetics education in medical school: a qualitative study exploring educational experiences and needs
    Deanna E Telner
    University of Toronto, Canada
    Med Teach 30:192-8. 2008
    ..Genetic discoveries increasingly have an impact on clinical medicine. Primary care providers (PCPs) need to be prepared to address patients' concerns about their genetic risks...
  98. ncbi Neuroimaging and human genetics
    Georg Winterer
    Genes, Cognition and Psychosis Program, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    Int Rev Neurobiol 67:325-83. 2005
  99. ncbi A history of medical genetics in pediatrics
    David L Rimoin
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pediatr Res 56:150-9. 2004
    Medical genetics emerged from a basic science only one half century ago...
  100. ncbi The Bayesian revolution in genetics
    Mark A Beaumont
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, P O Box 228, Reading RG6 6AJ, UK
    Nat Rev Genet 5:251-61. 2004
  101. pmc Candida albicans genome sequence: a platform for genomics in the absence of genetics
    Frank C Odds
    Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
    Genome Biol 5:230. 2004
    ..Comparative genomic analysis highlights genes that may contribute to C. albicans survival and its fitness as a human commensal and pathogen...

Research Grants64

  1. Linkage Disequilibrium: mapping and positional cloning
    Newton Morton; Fiscal Year: 2006
    ..abstract_text> ..
  2. Genetics, Genomic Research, and Consent: Attitudes of Pediatric Cancer Survivors
    ANDREA PATENAUDE; Fiscal Year: 2007
    ..cancer (YASPC) in a multidisciplinary study of their attitudes, beliefs, and anticipated actions related to genetics, genetic testing and genomic research, 2...
  3. Prophylactic Mastectomy: The Patient Experience
    ANDREA PATENAUDE; Fiscal Year: 2004
    ..Future research may assess utility of this material for women considering PM and for health care providers. Data from the project will inform hypothesis formation for future studies of PM. ..
    Sidney Altman; Fiscal Year: 2003
    Gregory Petsko; Fiscal Year: 2006
    ..abstract_text> ..
  6. Natural Product Model of Action Studies
    CRAIG CREWS; Fiscal Year: 2008
    ..abstract_text> ..
  7. Pancreatic Stem Cell Induction by Small Molecules
    CRAIG CREWS; Fiscal Year: 2003
    ..g., identification of additional pancreatic stem cell marker proteins via differential gene analysis). ..
  8. Evolutionary Genomics of Drosophila
    Daniel Hartl; Fiscal Year: 2007
    ..abstract_text> ..
  9. The XP Variant: A Human Mutator Gene for UV Damage
    James Cleaver; Fiscal Year: 2005
    ..We will express hRad3O on the keratin 14 promoter for over-expression in the skin, and make targeted knockout of mRad3O in vivo to identify roles for hRad3O in promoting and preventing carcinogenesis. ..
  10. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    ..This study will provide a new level of understanding for a complex birth defect trait. ..
  11. Disulfide Bond Formation: Mechanisms for Isomerization and Novel Pathways
    Jonathan Beckwith; Fiscal Year: 2009
    ..g. insulin) and immunoglobulins (antibodies). Understanding how disulfide bonds are formed correctly gives information allowing efficient production of these proteins for medical purposes. ..
  12. DNA Damage and Neurodegeneration in Cockayne Syndrome
    James Cleaver; Fiscal Year: 2009
    ..Successful conclusion of these studies will expand our knowledge of mechanisms of neurodegeneration and lay groundwork for development of therapeutic approaches for CS patients. ..
    Daniel Hartl; Fiscal Year: 2002
    ..Analysis of the limited data presently available for these pseudogenes yields inconclusive, and possibly inconsistent, results. ..
    Daniel Hartl; Fiscal Year: 2003
    ..Aim 5 recognizes Sdic as a candidate gene with a possible role in postmating reproductive isolation between D. melanogaster and D. simulans, which will be tested by interspecific germline transformation. ..
    Allan Spradling; Fiscal Year: 2003
    ..Therefore, these studies will elucidate the structure and function of eukaryotic chromosomes, a subject of widespread importance to the genetics of all organisms, including humans.
  16. Analysis of Tumorigenic Signaling Pathways with PROTACS
    CRAIG CREWS; Fiscal Year: 2006
    ..This panel will be tested for use as a diagnostic tool for determining the best course of drug treatment. ..
    Jonathan Beckwith; Fiscal Year: 2005
    ..In addition, suppressors of an ftsQ null mutant, if obtained, may give a clue as to the protein's function. ..
  18. Lay and Expert Models of Gene-Environment Interaction
    Celeste Condit; Fiscal Year: 2008
    ..This will help recipients to adopt behaviors that will better stave off the risks identified by the tests. [unreadable] [unreadable] [unreadable]..
  19. Anti-inflammatory Natural Product Mode of Action Studies
    CRAIG CREWS; Fiscal Year: 2008
    ..abstract_text> ..
  20. "Model organisms to human biology: strategies for the future of genetic research"
    Allan Spradling; Fiscal Year: 2008
    ..The meeting is designed to highlight both human and model organism genetics in a complementary way...
    Ian Duncan; Fiscal Year: 2008
    ..Our work will provide insights into the functioning of Ahr, and may lead to a better understanding of how target gene specificity is controlled for signaling systems known to play an important role in cancer. ..
  22. Race and Public Communication about Human Variation
    Celeste Condit; Fiscal Year: 2003
    ..First, the project will employ focus groups to describe existing lay understandings of the relationships among genetics, race, and human characteristics (including disease)...
  23. A genome-wide association study to detect genetic variation for schizophrenia
    Edwin van den Oord; Fiscal Year: 2010
    ..We attempt to contribute to the rigorous evaluation of the common disease/common genetic variant model for schizophrenia, which is key to further understand its pathophysiology and develop effective treatments. ..
  24. A Genetic Study of GTS, OCD and ADHD
    David Pauls; Fiscal Year: 2009
    ..will be of direct benefit to patients concerned about recurrence in their families;ultimately, clarifying the genetics of these conditions may elucidate their pathogenesis and lead to more effective interventions...
  25. Genome-wide association study of MI in Caucasians
    Jeffrey R Gulcher; Fiscal Year: 2010
    Dieter Soll; Fiscal Year: 2001
    ..A second unique feature of archael aminoacyl-tRNA formation is the use of enzymes distinct from any yet found in either eubacteria or eukaryotes to generate lysyl-tRNA and cysteinyl-tRNA. ..
  27. Function and structure of pendrin in thyroid cells
    Peter Kopp; Fiscal Year: 2007
    ..These studies will provide fundamental insights into the (patho)physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
    UTTAM RAJBHANDARY; Fiscal Year: 2007
    ..3) To optimize the conditions for import of suppressor tRNAs aminoacylated with amino acid analogues into mammalian cells and to use them for site specific insertion into proteins. ..
    PATRICK STOVER; Fiscal Year: 2007
    ..2). to determine the risk that folate catabolism contributes to folate-associated pathologies. (3). to establish relationships between catecholamines and folate metabolism. ..
  30. Design and analysis of adaptive multistage genetic association studies
    Edwin van den Oord; Fiscal Year: 2010
    ..The goal of this project is to develop a flexible framework for designing these studies in a cost-effective way and optimize subsequent replication efforts. ..
  31. A Twin Study of Imitative Behavior
    SUSAN FENSTERMACHER; Fiscal Year: 2007
    ..In addition, temperament and cognitive performance will be analyzed to determine their potential relationship to the observed variability in imitation. [unreadable] [unreadable] [unreadable] [unreadable]..
  32. Obesity and Mortality
    David Allison; Fiscal Year: 2009
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  33. Transcription Factors in Trophectoderm Differentiation
    Robert Roberts; Fiscal Year: 2007
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  34. DNA Patent Policies at Academic Institutions
    LeRoy Walters; Fiscal Year: 2003
    ..S. and Canadian academic institutions. ..
    SHIGERU SAKONJU; Fiscal Year: 2003
    ..The last two aims seek to address how the PcG complex silences gene expression, examining two potential mechanisms- chromosomal context, and chromatin structure. ..
    Kathryn Anderson; Fiscal Year: 2003
    ..The afternoons will be devoted to poster sessions and workshops. A special education symposium will address issues for teachers and for those interested in presenting science to the broader community. ..
  37. Molecular Pathology of Cardic Arrhythmias
    Dan Roden; Fiscal Year: 2003
    ..abstract_text> ..
    David Allison; Fiscal Year: 2002
    ..This study will, for the first time, allow a rigorous experimental test of the hypothesis that among obese organisms, WL promotes longevity. ..
    Julian Simon; Fiscal Year: 2001
    ..The yeast experiments will involve both classical genetic approaches and genome-wide analyses based on DNA microarray technology. ..
    MARY PARDUE; Fiscal Year: 2001
  41. A Study of Mutation Dynamics in Biological Systems
    Emmanuel Tannenbaum; Fiscal Year: 2005
    ..This study will require the use of genomic and proteomic databases, as well as predictive methods from computational biology, in order to determine the function of the various evolving components of the biological networks under study. ..
  42. New mitosis specific anticancer agents
    Julian Simon; Fiscal Year: 2005
    ..Through these convergent studies we hope to identify new mitosis-specific anticancer agents, their targets and the contexts in which these compounds are most effective. ..
    Robert Bilder; Fiscal Year: 2006
    ..resources to provide bridging infrastructure and expertise in: Genomics, Pharmacogenomics and Statistical Genetics; Biostatistics and Psychometrics; Bioinformatics; Clinical Trial Design and Regulatory Affairs; and Bioethics...
  44. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  45. ANALYZE: Software for Joint Linkage and LD Analysis
    Joseph Terwilliger; Fiscal Year: 2005
    DESCRIPTION (Investigator's abstract): Two important aspects of statistical genetics research are development of new methods and application of such methods to datasets...
  46. Vitamin K: Genetics of Vascular Calcification
    Jose Ordovas; Fiscal Year: 2005
    ..This research should provide the basis for more comprehensive genetic studies aimed to provide better identification of risk and more precise therapeutic approaches for these age-related disorders. ..
  47. DNA Polymerase Beta and Breast Cancer
    Joann Sweasy; Fiscal Year: 2008
    ..The variants we obtain will be characterized in genetic and biochemical assays to determine if they have phenotypes that are consistent with cancer etiology. [unreadable] [unreadable] [unreadable]..
  48. An Exploratory Center for Obesity Research (RMI)
    Adam Drewnowski; Fiscal Year: 2006
    ..By promoting interagency collaborations, these efforts will help the NIH develop a roadmap on how to effectively translate research findings into national, state, and local health policy. [unreadable] [unreadable]..
  49. Variation and Quantitative Genetics in Model Organisms
    Detlef Weigel; Fiscal Year: 2004
    ..The meeting will focus both on animal and plant model organisms, in which the use of quantitative genetics is experiencing a renaissance...
    Janet Williams; Fiscal Year: 2002
    ..Increased knowledge of ethical aspects of genetic testing will enable professional nurses to incorporate this knowledge into their professional nursing roles. ..
    Dan Roden; Fiscal Year: 2006
    ..Moreover, variability in the extent of rifampin-mediated induction of the drug metabolizing enzyme, CYP3A, among subjects with variant OATP-C alleles, will also be tested. [unreadable] [unreadable]..
  52. Novel Functions for Telomerase Enzyme Complex in Vivo
    Steven Artandi; Fiscal Year: 2005
    ..Through analysis of a conditional knockout mouse, we will determine the role of endogenous telomerase in cells in culture and in stern/progenitor compartments in vivo. ..
  53. Mammalian genetic analysis of embryonic neural overgrow*
    Karen Artzt; Fiscal Year: 2006
    ..a number of model organisms have been used in the study of molecular development: those that have really good genetics or ones for which developing stages are readily accessible but for technical reasons genetic studies are not an ..
  54. Exploring Attitudes About Data Disclosure and Data-Sharing in Genomics Research
    Susanne Haga; Fiscal Year: 2008
    ..of data is relevant to all types of biomedical research, it has garnered particular attention with respect to genetics and genomics research due to some of the unique aspects of the data and the high public profile of the field...
  55. Molecular Genetics of Hox Genes and Kidney Development
    Deneen M Wellik; Fiscal Year: 2010
    ..Relevance: These studies will provide key insights into the molecular and mechanistic basis of Hox regulation in kidney development and disease. ..
  56. Proteomics: Inactivity-induced muscle insulin resistance
    Frank Booth; Fiscal Year: 2002
    ..Outcomes of this proposal will better establish that healthy active skeletal muscles interact with other organ systems to prevent the metabolic disorders of type 2 diabetes, atherosclerosis, and obesity. ..
  57. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  58. Approaches to the Genetics of Substance Dependence
    Joel Gelernter; Fiscal Year: 2007
    ..The purpose of this application is to enable the PI to pursue an extensive research program in genetics of substance dependence with sufficient time to devote to exploration of new research directions and mentorship ..
  59. Genomic Resources for Histoplasma capsulatum
    Elaine Mardis; Fiscal Year: 2002
    ..abstract_text> ..