Genomes and Genes
Summary: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.
Publications303 found, 100 shown here
- KEGG for representation and analysis of molecular networks involving diseases and drugsMinoru Kanehisa
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
Nucleic Acids Res 38:D355-60. 2010..The new disease/drug information resource named KEGG MEDICUS can be used as a reference knowledge base for computational analysis of molecular networks, especially, by integrating large-scale experimental datasets...
- EcoCyc: fusing model organism databases with systems biologyIngrid M Keseler
SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
Nucleic Acids Res 41:D605-12. 2013..coli biology. The utility of EcoCyc is enhanced by new tools available on the EcoCyc web site, and the development of EcoCyc as a teaching tool is increasing the impact of the knowledge collected in EcoCyc...
- The ERBB network: at last, cancer therapy meets systems biologyYosef Yarden
Department of Biological Regulation, Weizmann Institute of Science, 1 Hertzl Street, Candiotty Building, Room 312, Rehovot 76100, Israel
Nat Rev Cancer 12:553-63. 2012....
- A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011Jeffrey D Orth
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Mol Syst Biol 7:535. 2011..Like its predecessors, the iJO1366 reconstruction is expected to be widely deployed for studying the systems biology of E. coli and for metabolic engineering applications.
- Systems biology approach predicts immunogenicity of the yellow fever vaccine in humansTroy D Querec
Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
Nat Immunol 10:116-25. 2009A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever ..
- Network pharmacology: the next paradigm in drug discoveryAndrew L Hopkins
Division of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Dundee, UK
Nat Chem Biol 4:682-90. 2008..Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggests that exquisitely ..
- Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biologyPeter D Karp
Artificial Intelligence Center, SRI International, 333 Ravenswood Ave, AE206, Menlo Park, CA 94025, USA
Brief Bioinform 11:40-79. 2010..The software also supports comparative analyses of PGDBs, and provides several systems biology analyses of PGDBs including reachability analysis of metabolic networks, and interactive tracing of ..
- BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic modelsChen Li
European Bioinformatics Institute, Hinxton, UK
BMC Syst Biol 4:92. 2010..In addition, the models and their components should be cross-referenced with other resources in order to allow their unambiguous identification...
- A methodology for performing global uncertainty and sensitivity analysis in systems biologySimeone Marino
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
J Theor Biol 254:178-96. 2008....
- Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel diseaseSharon Greenblum
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 109:594-9. 2012..Here, we introduce a metagenomic systems biology computational framework, integrating metagenomic data with an in silico systems-level analysis of metabolic ..
- The biomass objective functionAdam M Feist
GT Life Sciences, Inc, 10520 Wateridge Circle, San Diego, CA 92122, USA
Curr Opin Microbiol 13:344-9. 2010..Here we review fundamental issues associated with its formulation and use to compute optimal growth states...
- Gene regulatory network inference: data integration in dynamic models-a reviewMichael Hecker
Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
Biosystems 96:86-103. 2009b>Systems biology aims to develop mathematical models of biological systems by integrating experimental and theoretical techniques...
- Systems biology: MetabonomicsJeremy K Nicholson
Nature 455:1054-6. 2008
- Towards a rigorous assessment of systems biology models: the DREAM3 challengesRobert J Prill
IBM T J Watson Research Center, Yorktown Heights, New York, United States of America
PLoS ONE 5:e9202. 2010b>Systems biology has embraced computational modeling in response to the quantitative nature and increasing scale of contemporary data sets. The onslaught of data is accelerating as molecular profiling technology evolves...
- Connecting extracellular metabolomic measurements to intracellular flux states in yeastMonica L Mo
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
BMC Syst Biol 3:37. 2009..Extracellular metabolome or metabolic profiling data, in particular, can provide an insightful view of intracellular physiological states in a noninvasive manner...
- Effects of abiotic stress on plants: a systems biology perspectiveGrant R Cramer
Department of Biochemistry and Molecular Biology, Mail Stop 330, University of Nevada, Reno, Nevada 89557, USA
BMC Plant Biol 11:163. 2011..Plant responses to these stresses are equally complex. Systems biology approaches facilitate a multi-targeted approach by allowing one to identify regulatory hubs in complex ..
- Systems biology of vaccination for seasonal influenza in humansHelder I Nakaya
Emory Vaccine Center, Emory University, Atlanta, Georgia, USA
Nat Immunol 12:786-95. 2011Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons...
- Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biologyT S Keshava Prasad
Institute of Bioinformatics, Bangalore, India
Methods Mol Biol 577:67-79. 2009....
- InnateDB: facilitating systems-level analyses of the mammalian innate immune responseDavid J Lynn
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
Mol Syst Biol 4:218. 2008....
- Boolean modeling in systems biology: an overview of methodology and applicationsRui Sheng Wang
Department of Physics, The Pennsylvania State University, University Park, PA 16802, USA
Phys Biol 9:055001. 2012..In this paper, we build on our research to provide a methodology overview of Boolean modeling in systems biology, including Boolean dynamic modeling of cellular networks, attractor analysis of Boolean dynamic models, as ..
- Event extraction for systems biology by text mining the literatureSophia Ananiadou
University of Manchester, Manchester M13 9PL, UK
Trends Biotechnol 28:381-90. 2010b>Systems biology recognizes in particular the importance of interactions between biological components and the consequences of these interactions. Such interactions and their downstream effects are known as events...
- Single-cell systems biology by super-resolution imaging and combinatorial labelingEric Lubeck
Program in Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, California, USA
Nat Methods 9:743-8. 2012..These experiments demonstrate that combinatorial labeling and super-resolution imaging of single cells is a natural approach to bring systems biology into single cells.
- Systems biology of stem cell fate and cellular reprogrammingBen D MacArthur
Department of Gene and Cell Medicine and Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
Nat Rev Mol Cell Biol 10:672-81. 2009....
- Global reconstruction of the human metabolic network based on genomic and bibliomic dataNatalie C Duarte
Bioengineering Department, University of California at San Diego, La Jolla, CA 92093 0412, USA
Proc Natl Acad Sci U S A 104:1777-82. 2007..These results highlight some of the applications enabled by the reconstructed human metabolic network. The establishment of this network represents an important step toward genome-scale human systems biology.
- Towards environmental systems biology of ShewanellaJames K Fredrickson
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Nat Rev Microbiol 6:592-603. 2008....
- Quantitative, high-resolution proteomics for data-driven systems biologyJürgen Cox
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried D 82152, Germany
Annu Rev Biochem 80:273-99. 2011b>Systems biology requires comprehensive data at all molecular levels. Mass spectrometry (MS)-based proteomics has emerged as a powerful and universal method for the global measurement of proteins...
- Systems biology and combination therapy in the quest for clinical efficacyJonathan B Fitzgerald
Merrimack Pharmaceuticals, One Kendall Square, Building 700 2nd floor, Cambridge, Massachusetts 02139, USA
Nat Chem Biol 2:458-66. 2006....
- Controlled vocabularies and semantics in systems biologyMelanie Courtot
Terry Fox Laboratory, Vancouver, Canada
Mol Syst Biol 7:543. 2011The use of computational modeling to describe and analyze biological systems is at the heart of systems biology. Model structures, simulation descriptions and numerical results can be encoded in structured formats, but there is an ..
- InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curationKarin Breuer
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A1S6, Canada
Nucleic Acids Res 41:D1228-33. 2013..Finally, the recent integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism...
- A systems biology approach for pathway level analysisSorin Draghici
Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48202, USA
Genome Res 17:1537-45. 2007..By using a systems biology approach, we developed an impact analysis that includes the classical statistics but also considers other ..
- The heat shock response: systems biology of proteotoxic stress in aging and diseaseRichard I Morimoto
Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
Cold Spring Harb Symp Quant Biol 76:91-9. 2011..This complex, systems-wide interdependence ensures cellular health span and organismal life span...
- Impact of genome reduction on bacterial metabolism and its regulationEva Yus
Centre for Genomic Regulation CRG and Universitat Pompeu Fabra, Avenida Dr Aiguader 88, 08003 Barcelona, Spain
Science 326:1263-8. 2009....
- Systems Biology Toolbox for MATLAB: a computational platform for research in systems biologyHenning Schmidt
Fraunhofer Chalmers Research Centre for Industrial Mathematics, Chalmers Science Park, SE 41288 Göteborg, Sweden
Bioinformatics 22:514-5. 2006We present a Systems Biology Toolbox for the widely used general purpose mathematical software MATLAB...
- Maximizing the information content of experiments in systems biologyJuliane Liepe
Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London, United Kingdom
PLoS Comput Biol 9:e1002888. 2013..Constructing and inferring global mathematical models from experimental data is, however, central to systems biology. Different experimental setups provide different insights into such systems...
- The ciliopathies: a transitional model into systems biology of human genetic diseaseErica E Davis
Center for Human Disease Modeling, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Curr Opin Genet Dev 22:290-303. 2012....
- Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavirLi Xie
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America
PLoS Comput Biol 7:e1002037. 2011..This finding provides a molecular basis to explain the broad-spectrum anti-cancer effect of Nelfinavir and presents opportunities to optimize the drug as a targeted polypharmacology agent...
- Systems biology: parameter estimation for biochemical modelsMaksat Ashyraliyev
Centrum voor Wiskunde en Informatica, Amsterdam, The Netherlands
FEBS J 276:886-902. 2009..In this minireview, we discuss the identifiability of models, both intrinsic to the model and taking into account the available data. Furthermore, we give an overview of the most frequently used approaches to search the parameter space...
- Physicochemical modelling of cell signalling pathwaysBree B Aldridge
Center for Cell Decision Processes, Department Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Nat Cell Biol 8:1195-203. 2006....
- A decade of systems biologyHan Yu Chuang
Division of Medical Genetics, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Annu Rev Cell Dev Biol 26:721-44. 2010b>Systems biology provides a framework for assembling models of biological systems from systematic measurements...
- Eigengene networks for studying the relationships between co-expression modulesPeter Langfelder
Department of Human Genetics and Department of Biostatistics, University of California, Los Angeles, CA 90095, USA
BMC Syst Biol 1:54. 2007..Ample literature exists on how to detect biologically meaningful modules in networks but there is a need for methods that allow one to study the relationships between modules...
- A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomasKartik M Mani
Department of Biomedical Informatics DBMI, Columbia University, New York, NY 10032, USA
Mol Syst Biol 4:169. 2008..In this paper, we introduce a systems biology approach, based on the analysis of molecular interactions that become dysregulated in specific tumor ..
- Geometric interpretation of gene coexpression network analysisSteve Horvath
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America
PLoS Comput Biol 4:e1000117. 2008..The unification of coexpression network methods with traditional data mining methods can inform the application and development of systems biologic methods...
- Structural identifiability of systems biology models: a critical comparison of methodsOana Teodora Chis
Bioprocess Engineering Group, IIM CSIC, Vigo, Spain
PLoS ONE 6:e27755. 2011..The results reveal that the generating series approach, in combination with identifiability tableaus, offers the most advantageous compromise among range of applicability, computational complexity and information provided...
- How to infer gene networks from expression profilesMukesh Bansal
Telethon Institute of Genetics and Medicine, Via P Castellino, Naples, Italy
Mol Syst Biol 3:78. 2007....
- Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4Mark Gilchrist
Institute for Systems Biology, Seattle, Washington 98103, USA
Nature 441:173-8. 2006..Because ATF3 is itself induced by lipopolysaccharide, it seems to regulate TLR-stimulated inflammatory responses as part of a negative-feedback loop...
- Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisSarah L Kinnings
Department of Biology, University of York, York, UK
PLoS Comput Biol 5:e1000423. 2009..Previously we developed a chemical systems biology approach to identify off-targets of major pharmaceuticals on a proteome-wide scale...
- A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processesMehul S Suthar
Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
PLoS Pathog 9:e1003168. 2013..Using a systems biology approach, we defined the host innate immune response signature and actions that restrict WNV tissue tropism...
- Boolean network model predicts cell cycle sequence of fission yeastMaria I Davidich
Institut fur Theoretische Physik, Universitat Bremen, Bremen, Germany
PLoS ONE 3:e1672. 2008..While the latter operates in a strongly damped mode, driven by external excitation, the S. pombe network represents an auto-excited system with external damping...
- Network analyses in systems pharmacologySeth I Berger
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Bioinformatics 25:2466-72. 2009..Taken together, these types of analyses can lead to new therapeutic options while improving the safety and efficacy of existing medications...
- Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale modelsNathan E Lewis
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
Mol Syst Biol 6:390. 2010..Thus, differential gene and protein expression from wild-type and adaptively evolved strains supports observed growth phenotype changes, and is consistent with GEM-computed optimal growth states...
- Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesDouglas B Kell
School of Chemistry and The Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester M1 7DN, UK
Arch Toxicol 84:825-89. 2010..g. of iron chelators plus antioxidants) are likely to prove most effective. A variety of systems biology approaches, that I summarise, can predict both the mechanisms involved in these cell death pathways and the ..
- The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networksNeil Swainston
Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, United Kingdom
J Integr Bioinform 8:186. 2011..The individual modules manipulate reconstructions encoded in Systems Biology Markup Language (SBML), and can be chained to generate a reconstruction pipeline, or used individually during ..
- Visualization of omics data for systems biologyNils Gehlenborg
European Bioinformatics Institute, Cambridge, UK
Nat Methods 7:S56-68. 2010..In this review, we discuss how visualization tools are being used to help interpret protein interaction, gene expression and metabolic profile data, and we highlight emerging new directions...
- Structure-based systems biology for analyzing off-target bindingLei Xie
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, MC9743, 9500 Gilman Drive, La Jolla, CA 92093, USA
Curr Opin Struct Biol 21:189-99. 2011..While a very ambitious goal, some progress is being made...
- A data integration methodology for systems biologyDaehee Hwang
Institute for Systems Biology, Seattle, WA 98103, USA
Proc Natl Acad Sci U S A 102:17296-301. 2005..In an accompanying companion paper, we demonstrate the applicability of our approach to biological data. We have integrated our methodology into a free open source software package named POINTILLIST...
- Condition-dependent cell volume and concentration of Escherichia coli to facilitate data conversion for systems biology modelingBenjamin Volkmer
Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
PLoS ONE 6:e23126. 2011b>Systems biology modeling typically requires quantitative experimental data such as intracellular concentrations or copy numbers per cell...
- Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnologyJacek Puchałka
Synthetic and Systems Biology Group, Helmholtz Center for Infection Research HZI, Braunschweig, Germany
PLoS Comput Biol 4:e1000210. 2008..The solidly validated model yields valuable insights into genotype-phenotype relationships and provides a sound framework to explore this versatile bacterium and to capitalize on its vast biotechnological potential...
- Systems biology of tomato fruit development: combined transcript, protein, and metabolite analysis of tomato transcription factor (nor, rin) and ethylene receptor (Nr) mutants reveals novel regulatory interactionsSonia Osorio
Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam Golm, Germany
Plant Physiol 157:405-25. 2011..These results further revealed multiple ethylene-associated events during tomato ripening, providing new insights into the molecular biology of ethylene-mediated ripening regulatory networks...
- Environments that induce synthetic microbial ecosystemsNiels Klitgord
Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America
PLoS Comput Biol 6:e1001002. 2010....
- Software for systems biology: from tools to integrated platformsSamik Ghosh
The Systems Biology Institute, Minato, Tokyo, Japan
Nat Rev Genet 12:821-32. 2011..Such tools are needed at each step of a systems biology computational workflow, which typically consists of data handling, network inference, deep curation, ..
- A systems approach to prion diseaseDaehee Hwang
Institute for Systems Biology, Seattle, WA 98103, USA
Mol Syst Biol 5:252. 2009..Our systems analysis provides a comprehensive basis for developing models for prion replication and disease, and suggests some possible therapeutic approaches...
- Genome-scale gene/reaction essentiality and synthetic lethality analysisPatrick F Suthers
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA
Mol Syst Biol 5:301. 2009..By analyzing the functional classifications of the genes involved in synthetic lethals, we reveal surprising connections within and across clusters of orthologous group functional classifications...
- Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biologyMelissa Kemp
The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
Free Radic Biol Med 44:921-37. 2008..b>Systems biology provides approaches to address the complexity of these responses...
- Functional integration of a metabolic network model and expression data without arbitrary thresholdingPaul A Jensen
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
Bioinformatics 27:541-7. 2011..This procedure requires selecting relatively subjective expression thresholds, often requiring several iterations and refinements to capture the expression dynamics and retain model functionality...
- Metabolomics for functional genomics, systems biology, and biotechnologyKazuki Saito
RIKEN Plant Science Center, Tsurumi ku, Yokohama, Japan
Annu Rev Plant Biol 61:463-89. 2010..b>Systems biology driven by metabolome data will aid in deciphering the secrets of plant cell systems and their application to ..
- VirtualPlant: a software platform to support systems biology researchManpreet S Katari
Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003, USA
Plant Physiol 152:500-15. 2010..VirtualPlant enables scientists to visualize, integrate, and analyze genomic data from a systems biology perspective...
- Systems biology: experimental designClemens Kreutz
Physics Department, University of Freiburg, Germany
FEBS J 276:923-42. 2009..Furthermore, the relevant classical aspects of experimental design, such as randomization, replication and confounding, are reviewed...
- Functional cis-regulatory genomics for systems biologyJongmin Nam
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 107:3930-5. 2010..This approach will qualitatively alter the practice of GRN construction as well as validation, and will impact many additional areas of regulatory system biology...
- The genetic control of growth rate: a systems biology study in yeastPinar Pir
Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
BMC Syst Biol 6:4. 2012..It has not been determined whether the set of HFC genes is the same at all growth rates or whether it is the same in conditions of nutrient limitation or excess...
- Network systems biology for drug discoveryD K Arrell
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Clin Pharmacol Ther 88:120-5. 2010b>Systems biology provides a platform for integrating multiple components and interactions underlying cell, organ, and organism processes in health and disease...
- Precise generation of systems biology models from KEGG pathwaysClemens Wrzodek
Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, Tubingen, Germany
BMC Syst Biol 7:15. 2013..Thus, a direct conversion into systems biology models would produce incomplete and erroneous models.
- VANTED v2: a framework for systems biology applicationsHendrik Rohn
Leibniz Institute of Plant Genetics and Crop Plant Research IPK, Corrensstr 3, 06466 Gatersleben, Germany
BMC Syst Biol 6:139. 2012..Networks provide a basis for the integration, analysis and visualization of multi-omics experimental datasets...
- Scaffold number in yeast signaling system sets tradeoff between system output and dynamic rangeTy M Thomson
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 108:20265-70. 2011..Additional analysis and experiment suggest that scaffold abundance sets a tradeoff between maximum system output and system dynamic range, a prediction supported by recent experiments...
- Computational systems biology and in silico modeling of the human microbiomeElhanan Borenstein
University of Washington, Seattle, 98195 5065, USA
Brief Bioinform 13:769-80. 2012..I also discuss possible future applications and research avenues that such metagenomic systems biology and predictive system-level models may facilitate.
- A unifying view of 21st century systems biologyMarc Vidal
Center for Cancer Systems Biology CCSB and Department of Cancer Biology, Dana Farber Cancer Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
FEBS Lett 583:3891-4. 2009....
- Detailing the optimality of photosynthesis in cyanobacteria through systems biology analysisJuan Nogales
Center for Systems Biology, University of Iceland, 101 Reykjavik, Iceland
Proc Natl Acad Sci U S A 109:2678-83. 2012..The results and modeling approach presented here may promote a better understanding of the photosynthetic process. They can also guide bioengineering projects toward optimal biofuel production in photosynthetic organisms...
- Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and developmentPiet H van der Graaf
Pfizer, Department of Pharmacometrics, Global Clinical Pharmacology, IPC 096, Sandwich, CT13 9NJ, UK
Pharm Res 28:1460-4. 2011..realisation that innovation could be dramatically catalysed by creating synergy at the interface between Systems Biology and PKPD, two disciplines which until now have largely existed in 'parallel universes' with a limited track ..
- Dynamical modeling and multi-experiment fitting with PottersWheelThomas Maiwald
Freiburg Center for Data Analysis and Modeling, Freiburg University, Freiburg, Germany
Bioinformatics 24:2037-43. 2008Modelers in Systems Biology need a flexible framework that allows them to easily create new dynamic models, investigate their properties and fit several experimental datasets simultaneously...
- Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspectiveRobi Tacutu
The Shraga Segal Department of Microbiology and Immunology, Center for Multidisciplinary Research on Aging, Ben Gurion University of the Negev, Beer Sheva, Israel
Aging (Albany NY) 3:1178-91. 2011..Our comprehensive data mining revealed over 250 genes tightly associated with CS. Using systems biology tools, we found that CS is closely interconnected with aging, longevity and ARDs, either by sharing common ..
- When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseasesVincent Navratil
Universite de Lyon, IFR128 Biosciences Lyon Gerland, Lyon 69007, France
BMC Syst Biol 5:13. 2011..New advances in the field are expected from systems-level modelling and integration of the incessant torrent of high-throughput "-omics" data...
- Comparative systems biology across an evolutionary gradient within the Shewanella genusKonstantinos T Konstantinidis
School of Civil and Environmental Engineering and School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332, USA
Proc Natl Acad Sci U S A 106:15909-14. 2009..Collectively, our results provide important new information toward beginning a systems-level understanding of bacterial species and genera...
- Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI networkTao Ma
MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Tsinghua National Laboratory of Information Science and Technology Department of Automation, Tsinghua University, Beijing 100084, China
Mol Biosyst 6:613-9. 2010b>Systems biology is a general trend of contemporary scientific development...
- Boolean network models of cellular regulation: prospects and limitationsStefan Bornholdt
Institute for Theoretical Physics, University of Bremen, Bremen, Germany
J R Soc Interface 5:S85-94. 2008..Finally, prospects of Boolean models in exploratory dynamical models for biological circuits and their mutants will be discussed...
- Modular cell biology: retroactivity and insulationDomitilla Del Vecchio
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
Mol Syst Biol 4:161. 2008..We introduce, in particular, a mechanism based on a phosphorylation-dephosphorylation cycle. This mechanism enjoys a remarkable insulation property, due to the fast timescales of the phosphorylation and dephosphorylation reactions...
- Practical limits for reverse engineering of dynamical systems: a statistical analysis of sensitivity and parameter inferability in systems biology modelsKamil Erguler
Centre for Bioinformatics, Imperial College London, UK
Mol Biosyst 7:1593-602. 2011..Here we present a comprehensive analysis of 180 systems biology models, which allows us to classify the parameters with respect to their contribution to the overall ..
- Drug-target networkMuhammed A Yildirim
Center for Cancer Systems Biology CCSB, Harvard Medical School, 44 Binney St, Boston, Massachusetts 02115, USA
Nat Biotechnol 25:1119-26. 2007..Significant differences in distance were found between etiological and palliative drugs. A recent trend toward more rational drug design was observed...
- Estimating parameters and hidden variables in non-linear state-space models based on ODEs for biological networks inferenceMinh Quach
IBISC FRE CNRS 2873, University of Evry and Genopole 523, place des terrasses 91025 Evry, France
Bioinformatics 23:3209-16. 2007..However, biological systems considered as dynamical, non-linear and generally partially observed processes may be difficult to estimate even if the structure of interactions is given...
- Transcript length bias in RNA-seq data confounds systems biologyAlicia Oshlack
Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Biol Direct 4:14. 2009..As yet, a rigorous analysis methodology has not been developed and we are still in the stages of exploring the features of the data...
- The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulationEdgar Wingender
Department of Bioinformatics, Medical School, University of Gottingen, Goldschmidtstr 1, D 37077 Gottingen, Germany
Brief Bioinform 9:326-32. 2008..In the following, I describe what the original concepts were, what their present status is and how they may be expected to contribute to future system biology approaches...
- Identifying disease-specific genes based on their topological significance in protein networksZoltan Dezso
GeneGo Inc, Renaissance Drive, Saint Joseph, Michigan 49085, USA
BMC Syst Biol 3:36. 2009..To be useful in a research or clinical laboratory, the results need to be translated to the level of testable hypotheses about individual genes and proteins within the condition of interest...
- Networks for systems biology: conceptual connection of data and functionF Emmert-Streib
Queen s University Belfast, Computational Biology and Machine Learning Lab, Center for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Belfast, UK
IET Syst Biol 5:185-207. 2011The purpose of this study is to survey the use of networks and network-based methods in systems biology. This study starts with an introduction to graph theory and basic measures allowing to quantify structural properties of networks...
- Metabolic syndrome: from epidemiology to systems biologyAldons J Lusis
Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Nat Rev Genet 9:819-30. 2008..Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn...
- Pathway analysis of coronary atherosclerosisJennifer Y King
Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University, Stanford, California 94305, USA
Physiol Genomics 23:103-18. 2005..A systems biology approach that accounts for gene interactions, incorporates nontranscriptionally regulated genes, and ..
- Reverse engineering the genotype-phenotype map with natural genetic variationMatthew V Rockman
Center for Genomics and Systems Biology, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
Nature 456:738-44. 2008..It is then possible to use this information about causes and effects to build models of probabilistic 'causal networks'. These networks are beginning to define the outlines of the 'genotype-phenotype map'...
- Stochastic modelling for quantitative description of heterogeneous biological systemsDarren J Wilkinson
School of Mathematics and Statistics and the Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE1 7RU, UK
Nat Rev Genet 10:122-33. 2009Two related developments are currently changing traditional approaches to computational systems biology modelling...
- Quantitative prediction of cellular metabolism with constraint-based models: the COBRA ToolboxScott A Becker
Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093 0412, USA
Nat Protoc 2:727-38. 2007..are included in the toolbox, allowing a user to input a genome-scale metabolic model distributed in Systems Biology Markup Language format and perform these calculations with just a few lines of code...
- A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic useFlorence T H Wu
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Cell Mol Med 14:528-52. 2010..physiological and pathological roles of sVEGFR1 is then given, with emphasis on the utility of computational systems biology models in deciphering the molecular mechanisms by which sVEGFR1's purported biological functions occur...
- Systems biology approaches and pathway tools for investigating cardiovascular diseaseCraig E Wheelock
Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden
Mol Biosyst 5:588-602. 2009b>Systems biology aims to understand the nonlinear interactions of multiple biomolecular components that characterize a living organism...
- Accomplishments in genome-scale in silico modeling for industrial and medical biotechnologyCaroline B Milne
Institute for Genomic Biology, University of Illinois, Urbana, IL, USA
Biotechnol J 4:1653-70. 2009..Going forward, genome-scale in silico models promise to extend their application and analysis scope to become a trans-formative tool in biotechnology...
- Cancer systems biology: a network modeling perspectivePamela K Kreeger
Department of Biomedical Engineering, University of Wisconsin Madison, Madison, WI 53706, USA
Carcinogenesis 31:2-8. 2010....
- GPU computing for systems biologyLorenzo Dematté
CoSBi Centre, Italy
Brief Bioinform 11:323-33. 2010..In this paper, we review some recent efforts in exploiting the processing power of GPUs for the simulation of biological systems...
- Mapping the Human Binary Interactome NetworkMARC contact VIDAL; Fiscal Year: 2010..Our modified specific aims are to: i) Provide an expanded high-confidence/high-coverage version of the human binary interactome map ii) Validate human binary interaction data iii) Analyze the expanded human interactome model ..
- Conference on Systems & BiologyMarc Vidal; Fiscal Year: 2005..One of the current limitations in the field of Systems Biology relates to the relative lack of students and post-docs who can both think in terms of systems and formulate ..
- Integrated interactome mappingMarc Vidal; Fiscal Year: 2006..abstract_text> ..
- A C. elegans localization-of-expression mapping projectMarc Vidal; Fiscal Year: 2005..Using a complete set of worm promoters, we then propose to develop high-throughput methods to localize gene expression in vivo and initiate a protein-DNA interaction mapping project (R33). ..
- Rewiring Pathways and Networks by Environmental PerturbationsMarc Vidal; Fiscal Year: 2010..The Center for Cancer Systems Biology (CCSB) at the Dana-Farber Cancer Institute, together with a growing number of laboratories, is mapping and ..
- Intelligent Information Systems for Systems BiologyLeroy Hood; Fiscal Year: 2003..Finally, we propose some novel educational programs designed to put graduate students together into interdisciplinary teams for problem solving. ..
- Correlative Multimodal Imaging of Cardiac Electrophysiology and MetabolismJOHN PETER contact WIKSWO; Fiscal Year: 2010..This work will be a key step towards developing improved metabolic therapies. ..
- Mathematical Modeling of Anthrax InfectionYoram Vodovotz; Fiscal Year: 2002..The results of the research proposed herein will not only impact the treatment of victims of anthrax infection, but will also yield a valuable tool for the treatment of sepsis in general. ..
- GPx-3, Vascular Oxidant Stress, and ThrombosisJoseph Loscalzo; Fiscal Year: 2006..abstract_text> ..
- HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDEJoseph Loscalzo; Fiscal Year: 2004..With these studies, we hope to gain insight into the molecular mechanisms of homocyst(e)ine-induced endothelial dysfunction and potential therapies for this common metabolic abnormality. ..
- Transport and Complexity in Biological SystemsARTHUR LANDER; Fiscal Year: 2004..abstract_text> ..
- NAPS2 Continuation - Genome-Wide Association Study of PancreatitisDavid C Whitcomb; Fiscal Year: 2010..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
- MOLECULAR GENETICS OF HEREDITARY PANCREATITISDavid Whitcomb; Fiscal Year: 2008..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
- TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCEARTHUR LANDER; Fiscal Year: 2007..Following completion of this program, trainees will be qualified for careers in Neuroscience research and/or teaching in basic science departments and medical schools, or for research careers in non-academic research laboratories. ..
- 14th Internatinal Symposium on Inherited DiseasesDavid Whitcomb; Fiscal Year: 2004..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
- PROTEOGLYCANS AND BRAIN DEVELOPMENTARTHUR LANDER; Fiscal Year: 2004..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
- GORDON RESEARCH CONFERENCE ON PROTEOGLYCANSARTHUR LANDER; Fiscal Year: 2002....
- SIGNALING PATHWAYS INTERACTIONS AND MAMMARY TUMORSRINIVAS RAVI IYENGAR; Fiscal Year: 2004..abstract_text> ..
- STRUCTURE AND FUNCTION OF SIGNAL TRANSDUCING COMPONENTSSRINIVAS RAVI IYENGAR; Fiscal Year: 2008..abstract_text> ..
- Blood Systems BiologyScott Diamond; Fiscal Year: 2008..Lay Statement: Blood is ideal for Systems Biology research since it is easily obtained from donors or patients, amenable to high throughput liquid handling ..
- Multiplexed HTS of Serine and Cysteine Proteases (RMI)Scott Diamond; Fiscal Year: 2005..The use of multiplexed assay on microarrays allows the generation of critical data for the chemical protease interactome. ..
- The Penn Center For Molecular DiscoveryScott Diamond; Fiscal Year: 2008..This project is responsive to the NIH Roadmap objectives to apply both establish HTS/Synthetic methods and emerging next generation technologies developed at the University of Pennsylvania. ..
- Connecting the Genome to the CytoplasmPamela A Silver; Fiscal Year: 2010..The experiments proposed in this grant will not only lead to new basic insights but also to new ways to analyze on a genome-wide level the situation in genetically defective cells and certain cancers. ..
- Mitochondria and Cardiac Cell DeathJames Weiss; Fiscal Year: 2007..unreadable] [unreadable]..
- PROPERTIES OF INWARD RECTIFIER K CHANNELSJames Weiss; Fiscal Year: 2007..abstract_text> ..
- MECHANOSENSITIVE MODULATION OF AIRWAY CONTRACTIONChi Ming Hai; Fiscal Year: 2008..Understanding the basic science of this cellular mechanism may lead to new methods for the treatment of airway diseases such as asthma. ..
- Towards Quantitative Study of Systems BiologyPing Ao; Fiscal Year: 2007..at the associate professorship level to complete my transition from theoretical physics into quantitative systems biology. My immediate goal is to deepen my understanding of biology and the related chemistry...
- Gordon Conference on Glycolipid & Sphingolipid BiologyALFRED MERRILL; Fiscal Year: 2002....
- TM4: Software for High-Dimensional Data AnalysisJohn Quackenbush; Fiscal Year: 2009....
- Reaction and Transport Dynamics in Human BloodScott Diamond; Fiscal Year: 2009..Overall, these studies seek to provide fundamental insight into cell-cell interacitions and coagulation biochemistry that occur under flow. ..
- Intracellular mycobacterial proteomeQingbo Li; Fiscal Year: 2008..They may be important for understanding the physiology of intracellular persistence of mycobacteria within different macrophages. ..
- Metabolic Oscillations in HeartJAMES N contact WEISS; Fiscal Year: 2010..These insights may suggest novel therapies to protect the heart from injury during metabolic stresses such as heart attacks. ..
- EXPRESSION PROFILING OF RODENT MODELS OF HUMAN DISEASEJohn Quackenbush; Fiscal Year: 2004..abstract_text> ..
- STRUCTURE/FUNCTION STUDIES OF LONG-CHAIN BASESALFRED MERRILL; Fiscal Year: 2003....
- ERBB 2 ERBB 3 HETERODIMERIC RECEPTOR OF CARCINOMASYosef Yarden; Fiscal Year: 2004..This model will be examined by using mutant receptors, and the recycling machinery characterized in details. The suspected cancer-inhibitory activity of drugs interfering with ErbB routing will be tested in vivo. ..
- Activity-Dependent Gene Expression in Human EpilepsyJeffrey A Loeb; Fiscal Year: 2010..abstract_text> ..
- NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIAMichael Joyner; Fiscal Year: 2004..Data from these patient- oriented studies have implications related to understanding the contribution of endothelial function in a variety of common diseases. ..
- Afterdepolarizations and Cardiac ArrhythmiasJames N Weiss; Fiscal Year: 2010..S. citizens each year. The goal is to use this information to develop novel therapies to prevent this deadly manifestation of heart disease. ..
- Integrated approaches to deriving predictive networks from public data sourcesJohn Quackenbush; Fiscal Year: 2010..The end goals will not only be to create the framework for creating such predictive models, but to develop software and tools to allow others in the community to create models for their own systems of interest. ..
- MODULATION BY GROWTH FACTORS AND SIGNAL TRANSDUCTIONALFRED MERRILL; Fiscal Year: 2003..abstract_text> ..
- Modeling of chemotactic sensing in DictyosteliumPablo Iglesias; Fiscal Year: 2007..unreadable] [unreadable]..
- Role of Small GTPases in Muscarinic Receptor TraffickingALFRED MERRILL; Fiscal Year: 2005..abstract_text> ..
- Renal 11b-Hydroxysteroid Dehydrogenases and HypertensionMingyu Liang; Fiscal Year: 2008..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..
- 2006 Glycolipid & Sphingolipid Gordon ConferenceALFRED MERRILL; Fiscal Year: 2007..abstract_text> ..
- GORDON RESEARCH CONFERENCE ON MAMMARY GLAND BIOLOGYMARY BARCELLOS HOFF; Fiscal Year: 2003..abstract_text> ..
- Metabolomic and Toxicogenetic Study of Ethanol ToxicityIvan Rusyn; Fiscal Year: 2009..Here, the investigators are proposing to use metabolomics and mouse models in a new systems biology approach for molecular dissection and discovery of biological pathways underlying the susceptibility to ..
- Genes Influencing Social BehaviorsDONALD WELLS PFAFF; Fiscal Year: 2010..Impact: OT may be involved in postpartum depression. OT systems certainly facilitate social recognition, disorders of which are prominent in autism and in schizophrenia. ..
- Quantifying Protein Predictors of Macrophage ResponsesJared Roach; Fiscal Year: 2007..This model will be a starting point for the development of a comprehensive network model of macrophage signaling. This approach will ultimately be applicable to a broad array of biological systems. ..
- Hierarchical Methods for Large BioMolecular ComplexesChandrajit L Bajaj; Fiscal Year: 2010..AIM 4: To implement, test, package and freely distribute our structural feature determination and fast search/fitting techniques. ..
- Molecular Fingerprinting of Breast Cancer DevelopmentVladimir Shulaev; Fiscal Year: 2009..At the same time they point to the molecular mechanisms of breast cancer origin and will increase our knowledge about the etiology of breast cancer. ..
- Functionality and Fracture Susceptibility of Corticocancellous StructuresKarl J Jepsen; Fiscal Year: 2010..This systems analysis, which examines the relationship among traits in the context of functionality, will provide new insight into the genetic basis of fracture susceptibility. ..
- Metabolomics of the Virus-host Cell InteractionJoshua D Rabinowitz; Fiscal Year: 2010..Such pathways, once identified, will be attractive new targets for antiviral therapy. ..
- International Conference on Molecular Systems BiologyMichael Savageau; Fiscal Year: 2004This application is a request for partial support of the International Conference on Molecular Systems Biology: Gene Circuitry, Dynamical Control in Biology and Medicine, and Biomedical Software Development and Integration (ICMSB'04), ..
- INTERACTIONS OF CALCIUM CHANNELS WITH ADAPTOR PROTEINSIlya Bezprozvanny; Fiscal Year: 2003....
- A signal transduction pathway database/modeling systemEric Mjolsness; Fiscal Year: 2006..3) Ingest and store results from computational simulations and provide tools for comparing, visualizing and mining simulation results. ..
- SLEEP, AGING, AND THE HYPOCRETIN/OREXIN SYSTEMTHOMAS KILDUFF; Fiscal Year: 2007..To address these questions, we will use a combination of in vivo physiological, neuroanatomical, molecular, and receptor pharmacological methods. ..
- DIFFERENTIAL FUNCTION AND REGULATION OF RUNX2 ISOFORMSL Quarles; Fiscal Year: 2007..These studies will define the unique functions of the N-terminal domains, and determine if translational regulation contributes to the tissue-specific expression of Runx2-I and Runx2-II isoforms. ..
- Computational Methods for ProteinsHagai Meirovitch; Fiscal Year: 2003..Our unique tools are applicable to a wide range of problems in structural biology, such as protein engineering, docking, and threading. ..
- DEVELOPMENT OF THE METACYC METABOLIC PATHWAY DATABASEPeter Karp; Fiscal Year: 2003....
- Vitamin D Status and Prostate CancerJAMES FLEET; Fiscal Year: 2008..These data will provide us with the mechanistic basis for dietary recommendations to prevent prostate cancer and optimize bone health. ..
- GIVEN BUILDING ANIMAL FACILITY UPGRADERussell Tracy; Fiscal Year: 2004....
- Encyclopedia of E. Coli Genes and MetabolismPeter Karp; Fiscal Year: 2005..SRI further proposes to develop new bioinformatics methods for comparative genomics, and for predicting nutritional requirements and essential genes of an organism form its metabolic network. ..
- Biomarkers of Formaldehyde Exposure and ToxicityLuoping Zhang; Fiscal Year: 2010..The data produced from these studies will be useful to public health agencies in their evaluation of the leukemia risk presented by formaldehyde. ..
- ENDOTHELIAL GENE REGULATION BY BIOMECHANICAL FORCESMICHAEL GIMBRONE; Fiscal Year: 2003....
- Role of Erythrocytes in Circulatory ControlRandy Sprague; Fiscal Year: 2004..abstract_text> ..
- Probabilistic Modeling of Information from Images and Text in Online JournalsRobert Murphy; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Genetic and Immunological Impact of the HRES-1/Rab4 Locus in SLEAndras Perl; Fiscal Year: 2008..Under Specific Aim 3, we will test the hypothesis that the HindIIIG653C allele, alone or in combination with other genetic factors of lupus-associated haplotypes, enhances the expression of HRES-1/Rab4. ..
- PHOSPHOLIPASE ACTIVATION BY G-PROTEIN-LINKED RECEPTORSAlex Brown; Fiscal Year: 2004..These studies will utilize both intact cells and cell-free preparations that retain purinergic receptor-stimulated activation of PLD1. ..
- Exhaled Air Biomarkers in COPDNorbert Voelkel; Fiscal Year: 2005..abstract_text> ..
- ENDOTHELIAL CELL OUTGROWTH FROM BLOODRobert Hebbel; Fiscal Year: 2001..abstract_text> ..
- Myocardial Stiffness in Aging Associated Diastolic Heart FailureKenneth Campbell; Fiscal Year: 2007..The experimental results will provide new information about the underlying causes of DHF and should help scientists develop better treatments for diastolic dysfunction in elderly populations. [unreadable] [unreadable] [unreadable]..
- PROSTATE CELL PROLIFERATION IN CANCER AND AGINGANA SOTO; Fiscal Year: 2005..We expect that this research will lead to the development of markers to identify this phenotype, and to the development of specific therapeutic strategies. ..
- Perinatal xenoestrogen exposure: epigenesis and neoplasiaANA SOTO; Fiscal Year: 2007..This will also have a great impact on the way we study risk factors and conduct epidemiological studies; it may even influence public policy about breast cancer prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
- GORDON CONFERENCE ON ENVIRONMENTAL ENDOCRINE DISRUPTORSANA SOTO; Fiscal Year: 2002..abstract_text> ..
- Sex Differences in Dopamine SystemsArthur Arnold; Fiscal Year: 2006..e.g., Multiple Sclerosis). Understanding sex differences in brain function will help develop sex-specific strategies for treatment of brain diseases. ..