biochemistry

Summary

Top Publications

  1. ncbi The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms
    Colin Ratledge
    Lipid Research Centre, Department of Biological Sciences, University of Hull, HU6 7RX, United Kingdom
    Adv Appl Microbiol 51:1-51. 2002
  2. ncbi Rho GTPases: biochemistry and biology
    Aron B Jaffe
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom
    Annu Rev Cell Dev Biol 21:247-69. 2005
  3. ncbi Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry
    Wolfgang Eisenreich
    Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstr 4, D 85747 Garching, Germany
    Phytochemistry 68:2799-815. 2007
  4. pmc CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa
    Etienne Karita
    Projet San Francisco PSF, Kigali, Rwanda
    PLoS ONE 4:e4401. 2009
  5. pmc In-cell biochemistry using NMR spectroscopy
    David S Burz
    Department of Chemistry, State University of New York at Albany, Albany, New York, United States of America
    PLoS ONE 3:e2571. 2008
  6. pmc Chemistry and biochemistry of dietary polyphenols
    Rong Tsao
    Guelph Food Research Centre, Agriculture and Agri Food Canada, Guelph Ontario, N1G 5C9, Canada
    Nutrients 2:1231-46. 2010
  7. ncbi Improving the flavor of fresh fruits: genomics, biochemistry, and biotechnology
    Harry J Klee
    University of Florida, Horticultural Sciences, PO Box 110690, Gainesville, FL 23611 0690, USA
    New Phytol 187:44-56. 2010
  8. pmc Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design
    Lifeng Cai
    Beijing Institute of Pharmacology and Toxicology, Haidian District, Beijing 100850, China
    Curr Top Med Chem 11:2959-84. 2011
  9. ncbi A method for the quantitative site-specific study of the biochemistry within dental plaque biofilms formed in vivo
    C Robinson
    Division of Oral Biology, Leeds Dental Institute, UK
    Caries Res 31:194-200. 1997
  10. pmc In vivo biochemistry: applications for small molecule biosensors in plant biology
    Alexander M Jones
    Carnegie Institution for Science, Department of Plant Biology, 260 Panama St, Stanford, CA 94305, USA
    Curr Opin Plant Biol 16:389-95. 2013

Detail Information

Publications255 found, 100 shown here

  1. ncbi The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms
    Colin Ratledge
    Lipid Research Centre, Department of Biological Sciences, University of Hull, HU6 7RX, United Kingdom
    Adv Appl Microbiol 51:1-51. 2002
  2. ncbi Rho GTPases: biochemistry and biology
    Aron B Jaffe
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom
    Annu Rev Cell Dev Biol 21:247-69. 2005
    ..In the first part of this review, we present the best characterized of these biochemical pathways; in the second part, we attempt to integrate these molecular details into a biological context...
  3. ncbi Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry
    Wolfgang Eisenreich
    Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstr 4, D 85747 Garching, Germany
    Phytochemistry 68:2799-815. 2007
    ..This review summarizes some of the recent advances of high-resolution NMR spectroscopy in the field of plant sciences...
  4. pmc CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa
    Etienne Karita
    Projet San Francisco PSF, Kigali, Rwanda
    PLoS ONE 4:e4401. 2009
    ..The objective of this study was to establish clinical laboratory reference intervals for 25 hematology, immunology and biochemistry values among healthy African adults typical of those who might join a clinical trial.
  5. pmc In-cell biochemistry using NMR spectroscopy
    David S Burz
    Department of Chemistry, State University of New York at Albany, Albany, New York, United States of America
    PLoS ONE 3:e2571. 2008
    b>Biochemistry and structural biology are undergoing a dramatic revolution...
  6. pmc Chemistry and biochemistry of dietary polyphenols
    Rong Tsao
    Guelph Food Research Centre, Agriculture and Agri Food Canada, Guelph Ontario, N1G 5C9, Canada
    Nutrients 2:1231-46. 2010
    ..This paper is intended to review the chemistry and biochemistry of polyphenols as related to classification, extraction, separation and analytical methods, their occurrence ..
  7. ncbi Improving the flavor of fresh fruits: genomics, biochemistry, and biotechnology
    Harry J Klee
    University of Florida, Horticultural Sciences, PO Box 110690, Gainesville, FL 23611 0690, USA
    New Phytol 187:44-56. 2010
    ..However, our knowledge of the regulation of the critical metabolic pathways is still limited. Nonetheless, the pieces are in place for rapid advances to be made in the manipulation of flavor chemistry in the immediate future...
  8. pmc Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design
    Lifeng Cai
    Beijing Institute of Pharmacology and Toxicology, Haidian District, Beijing 100850, China
    Curr Top Med Chem 11:2959-84. 2011
    ....
  9. ncbi A method for the quantitative site-specific study of the biochemistry within dental plaque biofilms formed in vivo
    C Robinson
    Division of Oral Biology, Leeds Dental Institute, UK
    Caries Res 31:194-200. 1997
    ....
  10. pmc In vivo biochemistry: applications for small molecule biosensors in plant biology
    Alexander M Jones
    Carnegie Institution for Science, Department of Plant Biology, 260 Panama St, Stanford, CA 94305, USA
    Curr Opin Plant Biol 16:389-95. 2013
    ..Such information can now be obtained by transitioning from in vitro to in vivo biochemistry using biosensors...
  11. ncbi The biochemistry of RNA metabolism studied in situ
    Jeffrey A Nickerson
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    RNA Biol 6:25-30. 2009
    ..A newer technique--in vitro FRAP--assesses the regulation of binding and complex formation by co-factors in the nucleus...
  12. ncbi Microfluidics: applications for analytical purposes in chemistry and biochemistry
    Ken ichi Ohno
    Institute for Analytical Sciences, Dortmund, Germany
    Electrophoresis 29:4443-53. 2008
    ..recent advancements and novel developments in fluidic systems for applied analytical purposes in chemistry, biochemistry, and life science in general that employ and reflect the full benefits of microfluidics...
  13. ncbi Cell biochemistry studied by single-molecule imaging
    G I Mashanov
    Division of Physical Biochemistry, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Biochem Soc Trans 34:983-8. 2006
    ..Meanwhile, close scrutiny of individual fluorophore trajectories enables ideas about molecular dimerization and oligomerization related to function to be tested directly...
  14. ncbi From "butyribacterium" to "E. coli": an essay on unity in biochemistry
    Herbert C Friedmann
    Department of Biochemistry and Molecular Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Perspect Biol Med 47:47-66. 2004
    ..In that year Kluyver and his associate Hendrick Jean Louis Donker published a celebrated paper, "Unity in Biochemistry." The concept of biochemical unity had many antecedents, but these had never caught on...
  15. ncbi Bistability analyses of a caspase activation model for receptor-induced apoptosis
    Thomas Eissing
    Institute for Systems Theory in Engineering, University of Stuttgart, Pfaffenwaldring 9, 70550 Stuttgart, Germany
    J Biol Chem 279:36892-7. 2004
    ..In addition, the results from our model studies allowed us to reconcile the fast kinetics of caspase 3 activation observed at the single cell level with the much slower kinetics found at the level of a cell population...
  16. ncbi Spin biochemistry: magnetic 24Mg-25Mg-26Mg isotope effect in mitochondrial ADP phosphorylation
    Anatoly L Buchachenko
    NN Semenov Institute for Chemical Physics, Russian Academy of Sciences, Moscow
    Cell Biochem Biophys 43:243-51. 2005
    ..Therefore, the key mitochondrial phosphotransferases work as a magnesium nuclear spin mediated molecular machines...
  17. pmc RuleBender: integrated modeling, simulation and visualization for rule-based intracellular biochemistry
    Adam M Smith
    Department of Computer Science, University of Pittsburgh, PA 15260, USA
    BMC Bioinformatics 13:S3. 2012
    ..However, novel visual tools are needed in order to make RBM accessible to a broad range of users, to make specification of models less error prone, and to improve workflows...
  18. ncbi Cy5.5-DTPA-galactosyl-dextran: a fluorescent probe for in vivo measurement of receptor biochemistry
    David R Vera
    Department of Radiology, University of California, San Diego, La Jolla, 92093, USA
    Nucl Med Biol 32:687-93. 2005
    The high sensitivity of fluorescent reporters offers an opportunity to analytically probe the biochemistry of in vivo receptor systems with low target tissue concentration...
  19. pmc IntEnz, the integrated relational enzyme database
    Astrid Fleischmann
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 32:D434-7. 2004
    ..IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at http://www.ebi.ac.uk/intenz...
  20. ncbi Covalent inhibitors of glycosidases and their applications in biochemistry and biology
    Brian P Rempel
    Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Glycobiology 18:570-86. 2008
    ....
  21. ncbi Applications and trends in systems biology in biochemistry
    Katrin Hübner
    Department of Modeling of Biological Processes, COS Heidelberg BioQuant, University of Heidelberg, Germany
    FEBS J 278:2767-857. 2011
    ..We point out which computational and experimental methods are employed most frequently and which trends in systems biology research can be observed. Finally, we discuss some problems that we have encountered in publications in the field...
  22. ncbi Analyzing cell fate control by cytokines through continuous single cell biochemistry
    Michael A Rieger
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    J Cell Biochem 108:343-52. 2009
    ..This prospect article will outline the necessity of continuous single cell biochemistry to unravel the biological functions of molecular cytokine signaling...
  23. pmc Structure and biochemistry of cadherins and catenins
    Lawrence Shapiro
    Department of Biochemistry and Molecular Biophysics and Edward S Harkness Eye Institute, Columbia University, New York, New York 10032, USA
    Cold Spring Harb Perspect Biol 1:a003053. 2009
    ..Rather than stably bridging beta-catenin to actin, it appears that alpha-catenin actively regulates the actin cytoskeleton at cadherin-based cell-cell contacts...
  24. ncbi Biochemistry of the intervertebral disc
    T R Oegema
    Department of Orthopaedic Surgery, University of Minnesota, Minneapolis 55455
    Clin Sports Med 12:419-39. 1993
    In comparison to other tissues, understanding the disc biochemistry is only in the very early stage. The few facts that are known would point to strategies for interventions to alter disc biology and maintain disc biomechanics.
  25. ncbi Soft lithography in biology and biochemistry
    G M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Biomed Eng 3:335-73. 2001
    ..Self-assembled monolayers of alkanethiolates on gold are particularly easy to pattern by soft lithography, and they provide exquisite control over surface biochemistry.
  26. ncbi The plastoglobule: a bag full of lipid biochemistry tricks
    Claire Bréhélin
    Laboratoire de Physiologie Vegetale, Universite de Neuchatel, Neuchatel, Switzerland
    Photochem Photobiol 84:1388-94. 2008
    ..This review will give a summary of research, past and present, attempting to elucidate the role of plastoglobules in the context of plastid function...
  27. ncbi 100 years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry
    W H Koppenol
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, Zurich, Switzerland
    Redox Rep 6:339-41. 2001
    ....
  28. ncbi Antifouling enzymes and the biochemistry of marine settlement
    Jakob Broberg Kristensen
    Interdisciplinary Nanoscience Center iNANO, University of Aarhus, Aarhus C, Denmark
    Biotechnol Adv 26:471-81. 2008
    ..The validity of the various modes of action is evaluated and the groups of enzymes with the highest potential are highlighted...
  29. pmc Mapping enzymatic catalysis using the effective fragment molecular orbital method: towards all ab initio biochemistry
    Casper Steinmann
    Department of Chemistry, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e60602. 2013
    ..We determine the reaction barrier of chorismate mutase to be [Formula: see text] kcal mol(-1) for MP2/cc-pVDZ and [Formula: see text] for MP2/cc-pVTZ in an ONIOM approach using EFMO-RHF/6-31G(d) for the high and low layers, respectively...
  30. ncbi Clinical biochemistry education, training and continuing professional development in the United Kingdom
    Graham H Beastall
    Department of Clinical Biochemistry, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
    Clin Chim Acta 393:17-21. 2008
    Education and training to become a senior professional in UK clinical biochemistry is coordinated at national level and is largely dependent upon completion of the MRCPath examination...
  31. ncbi A course director's perspectives on problem-based learning curricula in biochemistry
    Harold C Smith
    Medical school biochemistry, Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Acad Med 77:1189-98. 2002
    Knowledge of the applications of biochemistry, molecular biology, and genetics in the practice of medicine has been and continues to be a vital part of medical students' and continuing education...
  32. ncbi Compounds of Mo, V and W in biochemistry and their biomedical activity
    Milena Jelikic-Stankov
    Faculty of Pharmacy, University of Belgrade, P O Box 146, 11 001 Belgrade, Serbia
    J Trace Elem Med Biol 21:8-16. 2007
    ..Also, compounds of these trace elements represent potent antiobesity agents and express hepatoprotective and antioxidative stress activity...
  33. ncbi Bifurcation discovery tool
    Vijay Chickarmane
    Keck Graduate Institute, Claremont, CA 91711, USA
    Bioinformatics 21:3688-90. 2005
    ....
  34. ncbi The effect of magnesium sulfate treatment on blood biochemistry and bleeding time in patients with severe preeclampsia
    Kadir Guzin
    SB Istanbul Goztepe Education and Research Hospital, Istanbul, Turkey
    J Matern Fetal Neonatal Med 23:399-402. 2010
    ..The objective of this study was to observe the effects of magnesium sulfate on various blood biochemical parameters and coagulation status of patients with preeclampsia...
  35. pmc The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens
    Christopher J Gobler
    School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY 11794 5000, USA
    ISME J 7:1333-43. 2013
    ..anophagefferens through its synthesis of a large arsenal of Se-dependent oxidoreductases that fine-tune cellular redox homeostasis. ..
  36. ncbi The concept lens diagram: a new mechanism for presenting biochemistry content in terms of "big ideas"
    Susan L Rowland
    School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Biochem Mol Biol Educ 39:267-79. 2011
    ..In biochemistry teaching, this radical shift from the content-based tradition is being driven by the "omics" information ..
  37. ncbi Recent advances in microfluidic technologies for biochemistry and molecular biologys
    Soongwon Cho
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland
    BMB Rep 44:705-12. 2011
    ..In this review, we highlight some of the recent advances in the application of microfluidics to biochemistry and molecular biology.
  38. ncbi Development and analysis of an instrument to assess student understanding of foundational concepts before biochemistry coursework
    Sachel M Villafañe
    Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA
    Biochem Mol Biol Educ 39:102-9. 2011
    b>Biochemistry is a challenging subject because student learning depends on the application of previously learned concepts from general chemistry and biology to new, biological contexts...
  39. pmc Microbial degradation of furanic compounds: biochemistry, genetics, and impact
    Nick Wierckx
    BIRD Engineering BV, Schiedam, The Netherlands
    Appl Microbiol Biotechnol 92:1095-105. 2011
    ....
  40. ncbi Impact of problem-based learning in a large classroom setting: student perception and problem-solving skills
    Andis Klegeris
    Department of Biology, University of British Columbia Okanagan, Kelowna, Canada
    Adv Physiol Educ 35:408-15. 2011
    ..as a supplement to standard didactic lectures in University of British Columbia Okanagan undergraduate biochemistry classes consisting of 45-85 students...
  41. ncbi Forensic biochemistry for functional investigation of death: concept and practical application
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Abeno, Osaka, Japan
    Leg Med (Tokyo) 13:55-67. 2011
    ..interference is inevitable and unpredictable in all forensic procedures; this is not particular to forensic biochemistry, but also occurs in morphology and toxicology...
  42. ncbi A review of hyperprolactinaemia and severe mental illness: are there implications for clinical biochemistry?
    Chris J Bushe
    Eli Lilly and Company Ltd, Basingstoke, UK
    Ann Clin Biochem 47:292-300. 2010
    ..Physicians must balance the benefits and risks of treatment when determining appropriate therapy for individual patients...
  43. ncbi BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom
    Anal Biochem 266:9-15. 1999
    ..These tetrameric proteins can be used to study protein receptor-ligand interactions at the cell surface, and site-specific biotinylation can be used to study proteins in vitro using a defined orientation...
  44. ncbi Engagement of students with lectures in biochemistry and pharmacology
    Elizabeth Ann Davis
    Department of Pharmacology, Monash University, Melbourne, Australia
    Biochem Mol Biol Educ 40:300-9. 2012
    ..actual lecture attendance of students over two year levels enrolled in two separate science disciplines, biochemistry and pharmacology. The study further sought to determine the factors that influence lecture attendance...
  45. pmc Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor
    Francis S Willard
    Translational Science and Technologies, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Exp Diabetes Res 2012:470851. 2012
    ....
  46. ncbi The structure, biochemistry, and metabolism of osteoarthritic cartilage: a review of the literature
    L C Dijkgraaf
    Department of Oral and Maxillofacial Surgery, University Hospital, Groningen, The Netherlands
    J Oral Maxillofac Surg 53:1182-92. 1995
    ..temporomandibular joint (TMJ), the pathogenesis of TMJ osteoarthritis (OA) is discussed, based on knowledge of structure, biochemistry and metabolism of osteoarthritic cartilage in general, and a classification of TMJ OA is presented.
  47. ncbi Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains
    Malin Bäckström
    Department of Medical Biochemistry, University of Gothenburg, Goteborg, Sweden
    Mol Biotechnol 54:250-6. 2013
    ..In order to study mucin biosynthesis and biochemistry, we and others have taken the alternative approach of constructing different recombinant proteins consisting of ..
  48. ncbi A participatory learning approach to biochemistry using student authored and evaluated multiple-choice questions
    Steven Bottomley
    School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Western Australia
    Biochem Mol Biol Educ 39:352-61. 2011
    ..traditional and a competitive assessment, was used to motivate students and promote a deep approach to learning biochemistry. Students were challenged to research, author, and explain their own multiple-choice questions (MCQs)...
  49. ncbi Editorial: vitamins and cofactors - chemistry, biochemistry and biology
    Finian J Leeper
    Nat Prod Rep 24:923-6. 2007
  50. ncbi A method for the rapid and efficient elution of native affinity-purified protein A tagged complexes
    Caterina Strambio-de-Castillia
    Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10021 6399, USA
    J Proteome Res 4:2250-6. 2005
    ..We show that Bio-Ox elution is a robust method for the efficient and rapid recovery of native tagged proteins, and can be applied to a variety of structural genomics and proteomics studies...
  51. pmc Impact of e-resources on learning in biochemistry: first-year medical students' perceptions
    Joe Varghese
    Department of Biochemistry, Christian Medical College, Vellore 632002, India
    BMC Med Educ 12:21. 2012
    ..The Department of Biochemistry at Christian Medical College (CMC), Vellore, India, has made available e-resources to first-year medical ..
  52. doi Computational biochemistry: old enzymes, new tricks
    Giovanna Ghirlanda
    Nature 453:164-6. 2008
  53. ncbi Salivary proline-rich proteins: biochemistry, molecular biology, and regulation of expression
    D M Carlson
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Crit Rev Oral Biol Med 4:495-502. 1993
    ..Salivary PRPs may constitute a defense mechanism against tannins and other polyhydroxylated phenols ingested. Putative transcriptional regulatory sequences have been identified in mouse PRP genes...
  54. pmc Kinetic analysis of γ-glutamyltransferase reaction process for measuring activity via an integration strategy at low concentrations of γ-glutamyl p-nitroaniline
    Zhi rong Li
    Key Laboratory of Medical Laboratory Diagnostics of Ministry of Education, Chongqing Medical University, Chongqing 400016, China
    J Zhejiang Univ Sci B 12:180-8. 2011
    ..0 U/L (n=5), and GGT activities in clinical sera responded linearly to their classical initial rates at 2.00 mmol/L GGPNA with an expected slope. Therefore, the integration strategy was successful in measuring GGT at 0.12 mmol/L GGPNA...
  55. ncbi Medical students' note-taking in a medical biochemistry course: an initial exploration
    Elizabeth H Morrison
    Department of Family Medicine, University of California, Irvine, CA 92868 3298, USA
    Med Educ 36:384-6. 2002
    ..University students perform best on post-lecture testing if they review a combination of provided notes and their own personal notes, particularly if the provided notes follow a 'skeletal' format that encourages active note-taking...
  56. ncbi Serum biochemistry in Nigerians with hyperglycemic emergencies
    Felicia Anumah
    Endocrinology Unit, Department of Medicine, Ahmadu Bello University Teaching Hospital Zaria, Kaduna State 810001, Nigeria
    Ethn Dis 18:26-30. 2008
    ..This biochemical aspect, which has not been examined in detail in Nigerians with hyperglycemic emergency was the focus of this study...
  57. ncbi The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals
    Angelo D'Alessandro
    Department of Environmental Sciences, University of Tuscia, Largo dell Università snc, 01100 Viterbo, Italy
    Expert Rev Proteomics 8:405-21. 2011
    ..This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of biochemistry, biomedicine and proteomics...
  58. ncbi From genes to whole organs: connecting biochemistry to physiology
    D Noble
    University Laboratory of Physiology, University of Oxford, UK
    Novartis Found Symp 239:111-23; discussion 123-8, 150-9. 2001
    ..Complexity in biological systems also arises from tissue and organ geometry. This is illustrated using modelling of the whole heart...
  59. ncbi Recent advances in Membrane Biochemistry
    J Malcolm East
    School of Biological Sciences, Life Sciences Building, University of Southampton, U K
    Biochem Soc Trans 39:703-6. 2011
    This Biochemical Society Annual Symposium on Recent Advances in Membrane Biochemistry was organized to bring together experts from across the spectrum of biomembrane disciplines from the biological to the biophysical/structural, with the ..
  60. ncbi Environmental biochemistry of chromium
    M E Losi
    Department of Soil and Environmental Sciences, University of California, Riverside 92521
    Rev Environ Contam Toxicol 136:91-121. 1994
    ..This has been shown to occur directly, by enzymatic processes at the cell membrane, and indirectly, with microbially produced H2S acting as the reductant.(ABSTRACT TRUNCATED AT 400 WORDS)..
  61. ncbi Biochemistry and neurobiology of prosaposin: a potential therapeutic neuro-effector
    Roberta Misasi
    Department of Geriatric and Neurology, Gifu University, School of Medicine, Gifu, Japan
    Cent Nerv Syst Agents Med Chem 9:119-31. 2009
    ....
  62. ncbi Structure, biochemistry and biology of hepoxilins: an update
    Santosh Nigam
    Eicosanoid and Lipid Research Division and Centre for Experimental Gynecology and Breast Research, Charité University Medical Centre Benjamin Franklin, Berlin, Germany
    FEBS J 274:3503-12. 2007
    ..The present review gives an update on the biochemistry, biology and clinical aspects of hepoxilin-based drug development...
  63. ncbi Serum biochemistry and morbidity among runners presenting for medical care after an Australian mountain ultramarathon
    Stephen A Reid
    St Helens Private Hospital, Tasmania, Australia
    Clin J Sport Med 17:307-10. 2007
    ..To determine if exercise-associated hyponatremia (EAH) was a cause of morbidity among runners requiring medical care at an Australian mountain ultramarathon...
  64. ncbi Origins and evolution of modern biochemistry: insights from genomes and molecular structure
    Gustavo Caetano-Anolles
    Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA
    Front Biosci 13:5212-40. 2008
    ..the genetic code, modules in the protein world, and diversification of life, and suggest early evolution of modern biochemistry was driven by recruitment of both RNA and protein catalysts in an ancient community of complex organisms.
  65. ncbi Biochemistry and physiology of mammalian secreted phospholipases A2
    Gerard Lambeau
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    Annu Rev Biochem 77:495-520. 2008
    ....
  66. ncbi A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:39105-14. 2004
    ....
  67. pmc Automatic policing of biochemical annotations using genomic correlations
    Tzu Lin Hsiao
    Center for Computational Biology and Bioinformatics and Department of Biomedical Informatics, Columbia University, Irving Cancer Research Center, New York, New York, USA
    Nat Chem Biol 6:34-40. 2010
    ..The experimental analysis of the mispredicted genes forming the leucine degradation pathway in B. subtilis demonstrates that computational policing tools can generate important biological hypotheses...
  68. ncbi Biochemistry of the initial steps of mycothiol biosynthesis
    Gerald L Newton
    Department of Chemistry and Biochemistry, University of California, La Jolla, California 92093, USA
    J Biol Chem 281:33910-20. 2006
    ..This demonstrates the presence of a myo-inositol transporter and a kinase that generates 1L-myo-inositol 1-phosphate. The biochemical pathway of mycothiol biosynthesis is now fully elucidated...
  69. ncbi In vivo biochemistry: quantifying ion and metabolite levels in individual cells or cultures of yeast
    Clara Bermejo
    Carnegie Institution for Science, Department of Plant Biology, 260 Panama St, Stanford, CA 94305, USA
    Biochem J 438:1-10. 2011
    ..We discuss the opportunities and potential pitfalls and the controls that help preclude misinterpretation...
  70. pmc The impact of biochemistry vs. population membership on floral scent profiles in colour polymorphic Hesperis matronalis
    Cassie J Majetic
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Ann Bot 102:911-22. 2008
    ..attribute variation in floral scent to differences in pollinator behaviour, ignoring the potential for shared biochemistry between floral scent and floral colour to dictate patterns of phenotypic variation in scent production...
  71. ncbi Recent developments in the biochemistry of chromium(III)
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Biol Trace Elem Res 99:1-16. 2004
    ..A discussion of these three events allows the current understanding of the nutritional biochemistry of Cr to be outlined.
  72. pmc Interactions of unconjugated bilirubin with vesicles, cyclodextrins and micelles: new modeling and the role of high pKa values
    Pasupati Mukerjee
    School of Pharmacy, University of Wisconsin, Madison, 53705 2222, USA
    BMC Biochem 11:15. 2010
    ....
  73. pmc Two DNA-binding and nick recognition modules in human DNA ligase III
    Elizabeth Cotner-Gohara
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:10764-72. 2008
    ..We present a jackknife model for ligase III that posits conformational changes during nick sensing and ligation to extend the versatility of the enzyme...
  74. doi Metabolomics: Biochemistry's new look
    Nathan Blow
    Nature 455:697-700. 2008
  75. ncbi Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation
    Heike Schulze
    LIMES Program Unit Membrane Biology and Lipid Biochemistry, Laboratory of Lipid Biochemistry, Kekulé Institut für Organische Chemie und Biochemie der Universität Bonn, Germany
    Biochim Biophys Acta 1793:674-83. 2009
    ..A considerable part of our current knowledge about mechanism and biochemistry of lysosomal lipid degradation is derived from a class of human diseases, the sphingolipidoses, which are ..
  76. ncbi Origins of life and biochemistry under high-pressure conditions
    Isabelle Daniel
    Laboratoire de Sciences de la Terre, UMR 5570 CNRS UCB Lyon1 ENS Lyon, Bât Géode, 2 rue Raphael Dubois, F 69622 Villeurbanne Cedex, France
    Chem Soc Rev 35:858-75. 2006
    ..After a short introduction to Earth history, the current tutorial review presents biological and physico-chemical arguments in support of high-pressure origin for life on Earth...
  77. ncbi Intrinsic protein disorder, amino acid composition, and histone terminal domains
    Jeffrey C Hansen
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
    J Biol Chem 281:1853-6. 2006
    ..We also discuss the potential structural consequences of acetylation and methylation of lysine residues embedded in intrinsically disordered histone tail domains...
  78. pmc Philip Siekevitz: Bridging biochemistry and cell biology
    David D Sabatini
    J Cell Biol 189:3-5. 2010
    ..He was a man of great integrity, with a thoroughly engaging personality and a humility not often found in people of his talent...
  79. ncbi Genetics and biochemistry of primary congenital glaucoma
    Mansoor Sarfarazi
    Molecular Ophthalmic Genetics Laboratory, University of Connecticut Health Center, Farmington 06030, USA
    Ophthalmol Clin North Am 16:543-54, vi. 2003
    ..This article also discusses the molecular evidence for reduced penetrance in congenital glaucoma and the phenotypic heterogeneity of CYP1B1 mutations, mouse models of CYP1B1, and the biochemistry of CYP1B1.
  80. ncbi Biochemistry. Mimicking posttranslational modifications of proteins
    Benjamin G Davis
    Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QY, UK
    Science 303:480-2. 2004
  81. ncbi Small group discussion followed by presentation as a revision exercise at the end of a teaching module in biochemistry
    Zachariah Bobby
    Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
    Natl Med J India 17:36-8. 2004
    ..followed by faculty-moderated presentation as a revision exercise after completion of a teaching module in biochemistry. We assessed the understanding of graduate medical students on the topic and the gain in retention of ..
  82. pmc A benchmark for methods in reverse engineering and model discrimination: problem formulation and solutions
    Andreas Kremling
    Systems Biology Group, Max Planck Institut fur Dynamik komplexer technischer Systeme, 39106 Magdeburg, Germany
    Genome Res 14:1773-85. 2004
    ..To verify calculated input profiles an interactive Web site (http://www.sysbio.de/projects/benchmark/) is provided. Several solutions based on linear and nonlinear models are discussed...
  83. ncbi Biochemistry and general genetics of nonribosomal peptide synthetases in fungi
    Hans von Döhren
    Technical University Berlin, Department of Chemistry, Research Group of Biochemistry and Molecular Biology, Franklinstrasse 29, 10587 Berlin, Germany
    Adv Biochem Eng Biotechnol 88:217-64. 2004
    ..The biochemistry of the sequential polymerisation reactions is reviewed, including multienzyme organization, amino acid ..
  84. ncbi Biochemistry and biomechanics of cell motility
    Song Li
    Department of Bioengineering and Center for Tissue Engineering, University of California, Berkeley, CA 94720, USA
    Annu Rev Biomed Eng 7:105-50. 2005
    ....
  85. ncbi A challenge for 21st century molecular biology and biochemistry: what are the causes of obligate autotrophy and methanotrophy?
    Ann P Wood
    Department of Life Sciences, King s College London, Franklin Wills Building, 150 Stamford Street, London SE1 9NN, UK
    FEMS Microbiol Rev 28:335-52. 2004
    ..This problem needs the technologies and mindsets of the present generation of molecular microbiologists to resolve it...
  86. ncbi Mechanical processes in biochemistry
    Carlos Bustamante
    Howard Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
    Annu Rev Biochem 73:705-48. 2004
    ..This review provides the conceptual framework to understand the role of mechanical force in biochemistry.
  87. ncbi Reverse engineering of biochemical equations from time-course data by means of genetic programming
    Masahiro Sugimoto
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan
    Biosystems 80:155-64. 2005
    ..The mean errors between given and simulation-predicted time-courses were 1.6 x 10(-5)% and 2.0 x 10(-3)%, respectively. Our equation prediction approach can be applied to identify metabolic reactions from observable time-courses...
  88. ncbi In singulo biochemistry: when less is more
    Carlos Bustamante
    Department of Physics and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Annu Rev Biochem 77:45-50. 2008
    ..We discuss here some of the advantages of single-molecule methods over their bulk counterparts and argue that these advantages should help establish them as essential tools in the technical arsenal of the modern biochemist...
  89. ncbi Biotechnology and biochemistry of marine natural products
    Abel Baerga-Ortiz
    Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, PO Box 365067, San Juan, Puerto Rico
    P R Health Sci J 28:251-7. 2009
    ....
  90. ncbi The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine
    Scott Blackwell
    Department of Clinical Biochemistry, Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
    Ann Clin Biochem 47:17-28. 2010
    ....
  91. doi Biochemistry. A postgenomic visual icon
    John N Weinstein
    Department of Bioinformatics and Computational Biology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Science 319:1772-3. 2008
  92. pmc Mechanical biochemistry of proteins one molecule at a time
    Andres F Oberhauser
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 283:6617-21. 2008
    ..Single-molecule mechanical techniques are providing fundamental information on the structure and function of proteins and are becoming an indispensable tool to understand how these molecules fold and work...
  93. pmc Analysis of YfgL and YaeT interactions through bioinformatics, mutagenesis, and biochemistry
    Phu Vuong
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    J Bacteriol 190:1507-17. 2008
    ..The five YfgL mutants defective in YaeT associations and the yfgL background were used to show that SurA binds to YaeT (or another complex member) without going through YfgL...
  94. ncbi Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry
    Silke Christine Wenzel
    Universitat des Saarlandes, Postfach 15 11 50, Saarbrucken, 66041, Germany
    Nat Prod Rep 24:1211-24. 2007
    ..Recent progress towards achieving a better understanding of the genetics and the biochemistry of myxobacterial secondary metabolism, revealed the involvement of numerous exceptional combinations of ..
  95. ncbi Evolving a lingua franca and associated software infrastructure for computational systems biology: the Systems Biology Markup Language (SBML) project
    M Hucka
    Control and Dynamical Systems, California Institute of Technology, Pasadena 91125, USA
    Syst Biol (Stevenage) 1:41-53. 2004
    ..We also provide a brief overview of the many SBML-compatible software tools available today...
  96. pmc Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes
    Philipp Selenko
    Department of Biological Chemistry, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:11904-9. 2006
    ..We also evaluate the experimental limitations of this method and discuss potential applications toward the in situ structural characterization of eukaryotic cellular activities...
  97. ncbi Relative quantification in proteomics: new approaches for biochemistry
    Richard D Unwin
    Stem Cell and Leukaemia Proteomics Laboratory, University of Manchester, Kinnaird House, Kinnaird Road, Withington, Manchester, M20 4QL, UK
    Trends Biochem Sci 31:473-84. 2006
    ..In addition, novel flow-cytometry-based approaches are considered. These technologies can all be used to determine accurately the levels of proteins or biomarkers in a wide range of samples...
  98. ncbi Tools for kinetic modeling of biochemical networks
    Rui Alves
    Departament Ciencies Mediques Basiques, Universidad de Lleida, Montserrat Roig, 4 25008 Lleida, Spain
    Nat Biotechnol 24:667-72. 2006
    ..Virtual Cell is the most versatile program and provides the simplest and clearest functionality for setting up multicompartmentalization...
  99. ncbi Genetics and biochemistry of polyhydroxyalkanoate granule self-assembly: The key role of polyester synthases
    Bernd H A Rehm
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Biotechnol Lett 28:207-13. 2006
    ..Biopolyesters and the respective micro-/nano-structures are currently considered as biocompatible and biodegradable biomaterials with numerous potential applications particularly in the medical field...
  100. ncbi Adding to the controversy: pitfalls in the diagnosis of testosterone deficiency syndromes with questionnaires and biochemistry
    A Morales
    Centre for Applied Urological Research, Kingston General Hospital and Queen s University, Kingston, Ontario, Canada
    Aging Male 10:57-65. 2007
    ..To determine the value of available questionnaires used for the diagnosis of testosterone deficiency syndromes (TDS) by correlating their ratings with a panel of hormonal determinations in a male population...
  101. ncbi Sialylation in protostomes: a perspective from Drosophila genetics and biochemistry
    Kate Koles
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843 2128, USA
    Glycoconj J 26:313-24. 2009
    ..We arrive at the conclusion that Drosophila is emerging as a useful model organism that is poised to shed new light on the function of sialylation not only in protostomes, but also in a larger evolutionary context...

Research Grants72

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  3. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  4. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..Aim 3. Biochemistry and biology of activation of prochemerin by serine/cysteine proteases and CPB...
  5. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2013
    ..Approach: The candidate will utilize a combination of molecular biology, biochemistry, cell biology, and mouse genetics to accomplish the research objective...
  6. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..includes oral and poster presentation sessions whose themes cover a range of topics including lysophospholipid biochemistry and signaling, pharmacology, and the role of lysophospholipids in disease...
  7. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..Lou Ann Brown of the Emory University Department of Pediatrics, a recognized authority on airway biochemistry, and the co-mentorships of Dr...
  8. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..These studies should be readily achieved by our team, which has extensive experience in sphingolipid biochemistry, Drosophila genetics, and the genetics and pathology of MD...
  9. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..Hematology and Cancer Biology at CCHMC and the Departments of Cancer and Cell Biology and Molecular Genetics, Biochemistry &Microbiology at UC with specifically relevant research interests to the Candidate's project and area ..
  10. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..investigators in the fields of innate and adaptive immunity, molecular biology, mucosal biology and physiology, biochemistry, high-throughput technology, microbiology, genomics, protein chemistry and clinical gastroenterology and ..
  11. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..and 7 research professors, all of who are funded by NIH or NSF, and are conducting active research in biochemistry, cell, molecular, and developmental biology...
  12. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..The proposed studies are aimed at understanding basic cellular mechanisms of gene expression, and may provide the basis for developing or improving diagnostic tools and therapeutic agents for these diseases. ..
  13. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..1 in complex with chloroquine, and 2- microscopy and biochemistry of trafficking of Kir3.1/Kir3...
  14. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..1 in complex with chloroquine, and 2- microscopy and biochemistry of trafficking of Kir3.1/Kir3...
  15. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..We will combine strategies from molecular biology, cell physiology, biochemistry, electrophysiology and confocal microscopy to accomplish our scientific goals...
  16. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..previous experience studying Drosophila melanogaster, by developing new scientific skills in physiology and biochemistry. These will be applied to the immediate goal of understanding the molecular mechanisms of regulation of SLC12 ..
  17. Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid Metabolism
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013
    ..and PhD degrees from the Albert Einstein College of Medicine in 2005, the latter degree earned in defining the biochemistry of the adipocyte-secreted hormone, adiponectin, and subsequently performed medical training in Internal ..
  18. Viral and Host Determinants of New World Alphaviral Entry
    ASIM AMINSHARIF AHMED; Fiscal Year: 2013
    ..achieve these immediate goals by attending a series of formal seminars and nanocourses in virology, protein biochemistry, genetic screening strategies and the responsible conduct of research...
  19. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..We propose to use a variety of techniques including biochemistry, immunolabeling, live-imaging, electrophysiology and behavioral tests, because a multidisciplinary approach ..
  20. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..His expertise resides in basement membrane and type IV collagen biochemistry and his seminal work includes the identification of the Goodpasture antigen and the development of pyridoxamine ..
  21. Biochemistry and Function of a Novel Bacterial Photosensory Two-Component System
    MELISSA MARKS; Fiscal Year: 2010
    ..Through this work we will gain a better understanding of the role the LovK/LovR two-component system and the ubiquitous environmental signal, sunlight, in the regulation of bacterial physiology and development. ..
  22. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..We hypothesize that TrkB is more important for [Ca2+]i regulation, while p75NTR regulates force. Using biochemistry, pharmacology, molecular biology, immunocytochemistry, fluorescence Ca2+ imaging, force measurement techniques, ..
  23. 4th ASM Conference on Prokaryotic Cell Biology and Development
    Susan S Golden; Fiscal Year: 2012
    ..Research in this area encompasses microbiology, molecular genetics, cell biology, biochemistry, structural biology, system biology, and theoretical modeling...
  24. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
    ..I find it particularly exciting that this project merges infectious disease with biochemistry and proteomics, with the overall goal of identifying novel drug targets for an important human pathogen...
  25. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..We use a combination of extensive biochemistry and molecular cell biology to explore the signal transduction mechanisms involved in BAAT1/ATM activation after ..
  26. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..in tissue culture cells using flow cytometry, confocal microscopy, immunofluorescence, molecular biology, and biochemistry. We will also employ mouse embryo fibroblasts and primary culture cells derived from mouse knock-out models...
  27. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ..Analyze Bach1 1 MafK binding to MARE/ARE-DNAs 1 5mC;3B. Analyze iron effects on FTL/FTH DNA 5mC. Techniques: Biochemistry (binding kinetics/equilibria, UV-vis fluorescence MCD/CD, NMR spectroscopies, and X-ray crystallography), ..
  28. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..Our combined expertise in the physiology of hypertension, connective tissue biochemistry and cardiovascular histomorphology place us in a unique position to pursue these directions of research.
  29. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..I believe that with my extensive biochemistry and cell biology background, being awarded a K99/R00 grant will promote and expedite the further development of ..
  30. Interrelationships among nutrients involved in one-carbon metabolism in Banglades
    MEGAN NINA HALL; Fiscal Year: 2011
    ..phase of this award will provide training in 1) study management and oversight, 2) advanced nutritional biochemistry and the mathematical modeling of one-carbon metabolism, and 3) laboratory sciences...
  31. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..My coursework was concentrated on reproductive physiology but also included biochemistry and cell biology, developmental biology, genetics, microbiology, and research ethics...
  32. Genetic &Functional Analyses of Hypertension Susceptibility Genes
    YEN PEI CHRISTY CHANG; Fiscal Year: 2013
    ..To accomplish these goals, we have brought together investigators who are experts in hypertension genetics, transcriptional regulation, bioinformatics, molecular biology, biochemistry, and renal physiology.
  33. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..My coursework was concentrated on reproductive physiology but also included biochemistry and cell biology, developmental biology, genetics, microbiology, and research ethics...
  34. Protein composition and interactions of telemeric chromatin
    Michael P Killoran; Fiscal Year: 2010
    ..Following my doctoral research, which combined structural biology and biochemistry to understand the biophysical details of protein function, I sought to balance my skills with cellular ..
  35. The Mucolipin TRP Ion Channels
    Haoxing Xu; Fiscal Year: 2013
    ..research is to apply a multidisciplinary approach using electrophysiology, Ca2+ imaging, immunochemistry, biochemistry, and fluorescence imaging to test our central hypotheses that TRPML1 mediates cation efflux from endosomes and ..
  36. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..7) Neural mechanisms of olfactory pattern recognition (Dr. Timothy Holy, WU);and (8) HIV-infection and lipid biochemistry (Dr. Kevin Yarasheski and Dr. David Clifford, WU)...
  37. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..focusing on identification of the cellular receptor and clinical consequences of unique 2Apro structure and biochemistry. Finally, in Project 3, Dr...
  38. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..Using the expertise in the Weiss lab, I will gain extensive hands-on experience in biochemistry which is essential for the identification of tissue-specific autoantigens. Additionally, Dr...
  39. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..proposal capitalizes on collaboration among experienced investigators in lipoprotein metabolism, nutritional biochemistry and adipocyte biology in a NIDDK-Nutrition Obesity Research Center to examine a clinical/therapeutic question ..
  40. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..Faculty advisors are investigators trained in various disciplines including: Physiology, Pharmacology, Biochemistry, Cell Biology, Neurobiology, Microbiology, Immunology, Exercise Science, Genetics, Molecular Biology, Internal ..
  41. CELLULAR REGULATION OF CLATHRIN ASSEMBLY AND FUNCTION
    Frances M Brodsky; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this research program is to understand clathrin biochemistry in order to elucidate how clathrin- coated vesicle (CCV) formation and function is regulated in cells...
  42. NAD Metabolism and Signaling
    Frances E Lund; Fiscal Year: 2011
    ..Participants and speakers will include those working in the areas of NAD enzymology, biochemistry, signal transduction, structural biology, DNA repair, transcription, nutrition, cell biology, physiology, ..
  43. Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
    Eve Donnelly; Fiscal Year: 2013
    ..The immediate goal of the proposed work is to provide critical training in collagen biochemistry and bone micro damage to enable characterization of the role of nonenzymatic glycation in bone fragility in ..
  44. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2013
    ..the studies because of the complimentary expertise of the principal investigator Jack Leahy ([unreadable]-cell biochemistry, physiology, in vivo animal models) with Tom Jetton (imaging techniques to study islet cell biology) and Mina ..
  45. Role of SIRT3 in fetal programming and kidney dysfunction
    Karen R Jonscher; Fiscal Year: 2013
    ..attain the educational background required to firmly anchor her ideas in the underlying biology and nutritional biochemistry of the systems she is investigating, 2) obtain exposure to molecular and cellular biology approaches that are ..
  46. UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAM
    Ezra Burstein; Fiscal Year: 2013
    ..The basic science training experience includes learning a variety of techniques in biochemistry, physiology, molecular biology and genetics, as well as participation in scientific meetings relevant to the ..
  47. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    ..approach will be used that will encompass diverse techniques (integrative physiology, protein chemistry, biochemistry, immunohistochemistry, proteomics, pathology, and histology) and will integrate proteomic and biochemical ..
  48. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..The proposed studies will be performed using cutting-edge techniques of biochemistry, molecular biology, and cell biology. The P.I...
  49. Molecular physiology of voltage-gated Ca2+ channels
    Jian Yang; Fiscal Year: 2013
    ..of mid-channel proteolysis, and the fate and function of the resulting hemi-channels, using a combination of biochemistry, proteomics, fixed cell and live cell imaging, and electrophysiology...
  50. REGULATION OF PHOSPHOLIPID SYNTHESIS
    George M Carman; Fiscal Year: 2013
    ..In these aims, we propose approaches that combine biochemistry and molecular genetics, coupled with mass spectrometry techniques, to determine sites of phosphorylation and to ..
  51. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Central Biochemistry Laboratory (CBL) serves the subjects and investigators of the continuing Prospective Study of Chronic Kidney Disease in Children (CKiD)...
  52. Examination of the Final Stages of Platelet Production
    JONATHAN NOAH THON; Fiscal Year: 2013
    ..President, Canadian Blood Services), entailed the application of proteomics, molecular biology, and biochemistry to identify mechanisms involved in regulating the storage-related deterioration of platelets (PLTs)...
  53. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2013
    ..Beyond the intrinsic biological importance of terpenoid metabolites, the study of microbial terpene biochemistry, structural biology, and molecular genetics provides a unique platform for the discovery of new biochemical ..
  54. Structural mechanism of DNA segregation by the pSK41 par system
    Maria Schumacher; Fiscal Year: 2010
    ..the structure of the ParM filament and examine its interaction with the segrosome using electron microscopy, biochemistry and cellular studies. Importantly, pSK41, harbored in S...
  55. ATM Controls Genomic Stability in Pluripotent Stem Cells
    JASON MARK BECKTA; Fiscal Year: 2013
    ..The goal of this proposal is to contribute to a greater understanding of processes that will impact future treatments and augment our understanding of cellular biochemistry.
  56. Transposons in Female Reproductive Health and Disease
    Zev Williams; Fiscal Year: 2013
    ..He is Professor of Biochemistry at The Rockefeller University and has trained and guided many postdoctoral fellows to independent research ..
  57. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..Four Cores (Administration and Biostatics, Celfular and Molecular Biology, Biochemistry, and Animal Resouroe) provide strong support to facilitate the integrative effort...
  58. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..plants and animals have viruses, so bacteria can be infected by bacteriophages that alter their metabolism and biochemistry. Phages have been used by scientists for many decades as exquisite genetic tools to probe many fundamental ..
  59. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..rash, and other bacterial and fungal meningitis/encephalitis can readily be differentiated from viral causes by biochemistry and gram staining of the cerebrospinal fluid...
  60. TOLLIP and Tuberculosis Immunopathogenesis
    JAVEED ALI SHAH; Fiscal Year: 2013
    ..immunology of T cells and dendritic cells at the NIH as Howard Hughes Research Scholar as well as protein biochemistry as an undergraduate at the University of Chicago...
  61. The Role of FKBP10 in Recessive Osteogenesis Imperfecta
    Caressa Lietman; Fiscal Year: 2013
    ..patients with OI and Bruck syndrome, especially through addressing altered cell signaling and altered collagen biochemistry which may affect it...
  62. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..I will gain in-depth experience in the areas of biochemistry, gene regulation, cellular electrophysiology, and in vivo physiology as applied to animal models of heart ..
  63. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..system, consisting of faculty members from Pediatric Nephrology, Biostatistics, Anatomy/Neural Sciences, and Biochemistry/Molecular Biophysics engaged in the following areas of research: molecular mechanisms of injury and repair of ..
  64. TRAINING PROGRAM IN GENETICS AND GENOMICS
    William Gelbart; Fiscal Year: 2006
    ..Biology (OEB), on the Arts and Sciences campus, include the Biological Laboratories, Sherman Fairchild Biochemistry Building, Museum of Comparative Zoology and Herbarium, and,within two years, a new facility housing the Center ..
  65. ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER
    Cecilia Giulivi; Fiscal Year: 2009
    ..has been recruited from various Departments across Campus (Molecular Biosciences, Immunology &Microbiology, Biochemistry &Molecular Medicine, Biological Chemistry, Pulmonary &Critical Care, Mechanical &Aeronautical ..
  66. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2005
    The overall objective of the proposed research is to gain insight into the biochemistry and physiological role of human beta-carotene 15,15'-dioxygenase (BCDO), an enzyme that catalyzes the first step in the synthesis of vitamin A from ..
  67. Investigating the molecular and mechanical regulation of pulsed actomyosin contra
    ADAM CHRISTOPHER MARTIN; Fiscal Year: 2010
    ..identifying the mechanisms that drive morphogenesis requires a multidisciplinary approach that includes biochemistry, genetics, cell and developmental biology, physics, and mathematical modeling...
  68. ANNUAL BIOMEDICAL RESEARCH WORKSHOPS
    JOSE TORRES RUIZ; Fiscal Year: 1999
    ..The principal investigator, Dr. Jose Torres-Ruiz, received the Ph.D. in biochemistry from Washington State University in 1987...
  69. Breast milk: Physiology, Biochemistry and Outcomes
    Ardythe Morrow; Fiscal Year: 2006
    ..The conference theme is Breast Milk: Physiology, Biochemistry and Outcomes and will be held in Niagara-on-the-Lake, Ontario, Canada...
  70. Lipids Interactions of Small Heat Shock Proteins
    Elizabeth Vierling; Fiscal Year: 2005
    ..Laszlo Vigh, Institute of Biochemistry, Szeged, Hungary...
  71. Purchase of Analytical Ultracentrifuge for Molecular Biophysics at Florida State
    TIMOTHY LOGAN; Fiscal Year: 2007
    ..requested for the purchase of an analytical ultracentrifuge to enhance the research capabilities in physical biochemistry at Florida State University...
  72. UAB Multi-user Fermentation Facility Upgrade
    NORMAN P HIGGINS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The Department of Biochemistry Fermentation Facility opened in 1984 with new equipment purchased from an NIH (S10) Shared Instrument Grant...