species specificity

Summary

Summary: Restriction of a characteristic or response to the members of one species; it usually refers to that property of the immune response which differentiates one species from another on the basis of antigen recognition, but the concept is not limited to immunology and is used loosely at levels higher than the species.

Top Publications

  1. ncbi RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
    Alexandros Stamatakis
    Swiss Federal Institute of Technology Lausanne, School of Computer and Communication Sciences Lab Prof Moret, Station 14, CH 1015 Lausanne, Switzerland
    Bioinformatics 22:2688-90. 2006
  2. ncbi PAML 4: phylogenetic analysis by maximum likelihood
    Ziheng Yang
    Department of Biology, Galton Laboratory, University College London, London, UK
    Mol Biol Evol 24:1586-91. 2007
  3. ncbi MicroRNAs: genomics, biogenesis, mechanism, and function
    David P Bartel
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 116:281-97. 2004
  4. ncbi Initial sequencing and analysis of the human genome
    E S Lander
    Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA
    Nature 409:860-921. 2001
  5. ncbi DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates
    O Folmer
    Center for Theoretical and Applied Genetics, Rutgers University, New Brunswick, New Jersey 08903 231
    Mol Mar Biol Biotechnol 3:294-9. 1994
  6. pmc Mauve: multiple alignment of conserved genomic sequence with rearrangements
    Aaron C E Darling
    Department of Computer Science, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Genome Res 14:1394-403. 2004
  7. ncbi The genetic legacy of the Quaternary ice ages
    G Hewitt
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Nature 405:907-13. 2000
  8. pmc Bayesian inference of species trees from multilocus data
    Joseph Heled
    Department of Computer Science, University of Auckland, New Zealand
    Mol Biol Evol 27:570-80. 2010
  9. ncbi Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation
    Ivica Letunic
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Bioinformatics 23:127-8. 2007
  10. ncbi Extinction risk from climate change
    Chris D Thomas
    Centre for Biodiversity and Conservation, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Nature 427:145-8. 2004

Detail Information

Publications343 found, 100 shown here

  1. ncbi RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
    Alexandros Stamatakis
    Swiss Federal Institute of Technology Lausanne, School of Computer and Communication Sciences Lab Prof Moret, Station 14, CH 1015 Lausanne, Switzerland
    Bioinformatics 22:2688-90. 2006
    ..The program has been used to compute ML trees on two of the largest alignments to date containing 25,057 (1463 bp) and 2182 (51,089 bp) taxa, respectively...
  2. ncbi PAML 4: phylogenetic analysis by maximum likelihood
    Ziheng Yang
    Department of Biology, Galton Laboratory, University College London, London, UK
    Mol Biol Evol 24:1586-91. 2007
    ..The package is written in ANSI C, and runs under Windows, Mac OSX, and UNIX systems. It is available at -- (http://abacus.gene.ucl.ac.uk/software/paml.html)...
  3. ncbi MicroRNAs: genomics, biogenesis, mechanism, and function
    David P Bartel
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 116:281-97. 2004
    ..Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes...
  4. ncbi Initial sequencing and analysis of the human genome
    E S Lander
    Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA
    Nature 409:860-921. 2001
    ..We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence...
  5. ncbi DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates
    O Folmer
    Center for Theoretical and Applied Genetics, Rutgers University, New Brunswick, New Jersey 08903 231
    Mol Mar Biol Biotechnol 3:294-9. 1994
    ..Preliminary comparisons revealed that these COI primers generate informative sequences for phylogenetic analyses at the species and higher taxonomic levels...
  6. pmc Mauve: multiple alignment of conserved genomic sequence with rearrangements
    Aaron C E Darling
    Department of Computer Science, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Genome Res 14:1394-403. 2004
    ..We have evaluated the quality of Mauve alignments and drawn comparison to other methods through extensive simulations of genome evolution...
  7. ncbi The genetic legacy of the Quaternary ice ages
    G Hewitt
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Nature 405:907-13. 2000
    ..The present genetic structure of populations, species and communities has been mainly formed by Quaternary ice ages, and genetic, fossil and physical data combined can greatly help our understanding of how organisms were so affected...
  8. pmc Bayesian inference of species trees from multilocus data
    Joseph Heled
    Department of Computer Science, University of Auckland, New Zealand
    Mol Biol Evol 27:570-80. 2010
    ..We demonstrate that both BEST and our method have much better estimation accuracy for species tree topology than concatenation, and our method outperforms BEST in divergence time and population size estimation...
  9. ncbi Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation
    Ivica Letunic
    EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Bioinformatics 23:127-8. 2007
    ..Various types of data such as genome sizes or protein domain repertoires can be mapped onto the tree. Export to several bitmap and vector graphics formats is supported. AVAILABILITY: iTOL is available at http://itol.embl.de..
  10. ncbi Extinction risk from climate change
    Chris D Thomas
    Centre for Biodiversity and Conservation, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Nature 427:145-8. 2004
    ..These estimates show the importance of rapid implementation of technologies to decrease greenhouse gas emissions and strategies for carbon sequestration...
  11. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  12. ncbi The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    Matthew Stremlau
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 427:848-53. 2004
    ..Our studies identify TRIM5alpha as a species-specific mediator of innate cellular resistance to HIV-1 and reveal host cell components that modulate the uncoating of a retroviral capsid...
  13. ncbi Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    A E Pasquinelli
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Nature 408:86-9. 2000
    ..elegans and Drosophila, at 48 hours after fertilization in zebrafish, and in adult stages of annelids and molluscs. The let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny...
  14. ncbi Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
    ....
  15. pmc Ten species in one: DNA barcoding reveals cryptic species in the neotropical skipper butterfly Astraptes fulgerator
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Proc Natl Acad Sci U S A 101:14812-7. 2004
    ..They also illustrate the value of DNA barcoding, especially when coupled with traditional taxonomic tools, in disclosing hidden diversity...
  16. ncbi Cryptic species as a window on diversity and conservation
    David Bickford
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Republic of Singapore
    Trends Ecol Evol 22:148-55. 2007
    ..The discovery of cryptic species is likely to be non-random with regard to taxon and biome and, hence, could have profound implications for evolutionary theory, biogeography and conservation planning...
  17. ncbi Sequence-based species delimitation for the DNA taxonomy of undescribed insects
    Joan Pons
    Department of Entomology, The Natural History Museum, London SW7 5BD, United Kingdom
    Syst Biol 55:595-609. 2006
    ....
  18. pmc The Arabidopsis lyrata genome sequence and the basis of rapid genome size change
    Tina T Hu
    Molecular and Computational Biology, University of Southern California, Los Angeles, California, USA
    Nat Genet 43:476-81. 2011
    ..The high-quality reference genome sequence for A. lyrata will be an important resource for functional, evolutionary and ecological studies in the genus Arabidopsis...
  19. pmc Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Science 328:1036-40. 2010
    ..Our results reveal large interspecies differences in transcriptional regulation and provide insight into regulatory evolution...
  20. ncbi Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
    M McClelland
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California 92121, USA
    Nature 413:852-6. 2001
    ..Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets...
  21. ncbi A general model of prion strains and their pathogenicity
    John Collinge
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, UK
    Science 318:930-6. 2007
    ..Recent advances suggest that prions themselves are not directly neurotoxic, but rather their propagation involves production of toxic species, which may be uncoupled from infectivity...
  22. ncbi Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
    H Tettelin
    The Institute for Genomic Research (TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 293:498-506. 2001
    ..Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity...
  23. ncbi ABGD, Automatic Barcode Gap Discovery for primary species delimitation
    N Puillandre
    UMR 7138, Museum national d histoire naturelle, Departement Systematique et Evolution, Paris, France
    Mol Ecol 21:1864-77. 2012
    ..In conclusion, ABGD is fast, simple method to split a sequence alignment data set into candidate species that should be complemented with other evidence in an integrative taxonomic approach...
  24. ncbi Of mice and not men: differences between mouse and human immunology
    Javier Mestas
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697
    J Immunol 172:2731-8. 2004
    ..We also provide examples, such as multiple sclerosis and delayed-type hypersensitivity, where complex multicomponent processes differ. Such differences should be taken into account when using mice as preclinical models of human disease...
  25. pmc Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor
    Matthew Stremlau
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School Division of AIDS, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:5514-9. 2006
    ..Inhibiting the proteasome did not abrogate restriction. Thus, TRIM5alpha restricts retroviral infection by specifically recognizing the capsid and promoting its rapid, premature disassembly...
  26. pmc Choosing and using a plant DNA barcode
    Peter M Hollingsworth
    Genetics and Conservation Section, Royal Botanic Garden Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e19254. 2011
    ....
  27. ncbi Rebuilding community ecology from functional traits
    Brian J McGill
    Department of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1
    Trends Ecol Evol 21:178-85. 2006
    ..We suggest this approach can create a more quantitative and predictive science that can more readily address issues of global change...
  28. ncbi Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    B Wightman
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:855-62. 1993
    ..These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation...
  29. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
    ..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
  30. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  31. ncbi Identification of grapevine microRNAs and their targets using high-throughput sequencing and degradome analysis
    Vitantonio Pantaleo
    Istituto di Virologia Vegetale, Consiglio Nazionale delle Ricerche, Torino, Italy
    Plant J 62:960-76. 2010
    ..Finally, 112 target mRNAs of known and 44 target mRNAs of new grapevine-specific miRNAs were identified by genomic-scale high-throughput sequencing of miRNA cleaved mRNAs...
  32. ncbi Soluble proteins in insect chemical communication
    P Pelosi
    Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa Italy, Agrarie via S Michele, 4, 56124, Pisa, Italy
    Cell Mol Life Sci 63:1658-76. 2006
    ..Finally, we discuss current ideas and models of the role of such proteins in insect chemoreception...
  33. ncbi One-third of reef-building corals face elevated extinction risk from climate change and local impacts
    Kent E Carpenter
    IUCN International Union for Conservation of Nature Species Programme Species Survival Commission SSC, Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA
    Science 321:560-3. 2008
    ..Our results emphasize the widespread plight of coral reefs and the urgent need to enact conservation measures...
  34. pmc Defining the normal bacterial flora of the oral cavity
    Jørn A Aas
    Institute of Oral Biology, University of Oslo, Postbox 1052 Blindern, 0316 Oslo, Norway
    J Clin Microbiol 43:5721-32. 2005
    ..It is important to fully define the human microflora of the healthy oral cavity before we can understand the role of bacteria in oral disease...
  35. pmc Identification of Birds through DNA Barcodes
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, Ontario, Canada
    PLoS Biol 2:e312. 2004
    ..The growing evidence for the effectiveness of DNA barcodes as a basis for species identification supports an international exercise that has recently begun to assemble a comprehensive library of COI sequences linked to named specimens...
  36. ncbi Effects of size and temperature on metabolic rate
    J F Gillooly
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA
    Science 293:2248-51. 2001
    ..Temperature and body size are primary determinants of biological time and ecological roles...
  37. ncbi Transposable elements have rewired the core regulatory network of human embryonic stem cells
    Galih Kunarso
    Computational and Mathematical Biology, Genome Institute of Singapore, Singapore, Singapore
    Nat Genet 42:631-4. 2010
    ..These data indicate that species-specific transposable elements have substantially altered the transcriptional circuitry of pluripotent stem cells...
  38. pmc Phylogenetic and functional assessment of orthologs inference projects and methods
    Adrian M Altenhoff
    Institute of Computational Science, ETH Zurich, and Swiss Institute of Bioinformatics, Zurich, Switzerland
    PLoS Comput Biol 5:e1000262. 2009
    ..Second, it introduces new methodology to verify orthology. And third, it sets performance standards for current and future approaches...
  39. ncbi DNA barcoding and taxonomy in Diptera: a tale of high intraspecific variability and low identification success
    Rudolf Meier
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore
    Syst Biol 55:715-28. 2006
    ..We conclude with an outlook on the prospects of obtaining complete barcode databases and the future use of DNA sequences in a modern integrative taxonomy...
  40. pmc Bayesian species delimitation using multilocus sequence data
    Ziheng Yang
    Center for Computational and Evolutionary Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 107:9264-9. 2010
    ..The statistical performance of the method is examined using simulations, and the method is illustrated by analyzing sequence data from rotifers, fence lizards, and human populations...
  41. pmc Chromosome triplication found across the tribe Brassiceae
    Martin A Lysak
    Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, United Kingdom
    Genome Res 15:516-25. 2005
    ..The presumed hexaploidization event occurred after the Arabidopsis-Brassiceae split, between 7.9 and 14.6 Mya...
  42. ncbi Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences
    Jerome C Regier
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Nature 463:1079-83. 2010
    ..These results provide a statistically well-supported phylogenetic framework for the largest animal phylum and represent a step towards ending the often-heated, century-long debate on arthropod relationships...
  43. pmc Genomic insights that advance the species definition for prokaryotes
    Konstantinos T Konstantinidis
    Center for Microbial Ecology, and Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 102:2567-72. 2005
    ....
  44. ncbi A novel influenza A virus mitochondrial protein that induces cell death
    W Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Nat Med 7:1306-12. 2001
    ..We propose that PB1-F2 functions to kill host immune cells responding to influenza virus infection...
  45. pmc The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical Pacific
    Douglas B Rusch
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Biol 5:e77. 2007
    ..Specific functional adaptations can be identified both within individual ribotypes and across the entire community, including proteorhodopsin spectral tuning and the presence or absence of the phosphate-binding gene PstS...
  46. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
    ..Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge...
  47. ncbi Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR
    T Rinttilä
    Section of Microbiology, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Helsinki University, Helsinki, Finland
    J Appl Microbiol 97:1166-77. 2004
    ..We report the design and optimization of an extensive set of 16S rDNA-targeted species- and group-specific primers for more accurate quantification of bacteria from faecal samples with real-time PCR...
  48. pmc Estimate of the mutation rate per nucleotide in humans
    M W Nachman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 156:297-304. 2000
    ..This high rate is difficult to reconcile with multiplicative fitness effects of individual mutations and suggests that synergistic epistasis among harmful mutations may be common...
  49. ncbi Simultaneous identification of species and molecular forms of the Anopheles gambiae complex by PCR-RFLP
    C Fanello
    London School of Hygiene and Tropical Medicine, London, UK
    Med Vet Entomol 16:461-4. 2002
    ..This procedure is more efficient, faster and cheaper than those used before, so is recommended for large-scale processing of field-collected larval and adult specimens to be identified in malaria vector studies...
  50. pmc Comparative and demographic analysis of orang-utan genomes
    Devin P Locke
    The Genome Center at Washington University, Washington University School of Medicine, 4444 Forest Park Avenue, Saint Louis, Missouri 63108, USA
    Nature 469:529-33. 2011
    ..Overall, the resources and analyses presented here offer new opportunities in evolutionary genomics, insights into hominid biology, and an extensive database of variation for conservation efforts...
  51. pmc Uberon, an integrative multi-species anatomy ontology
    Christopher J Mungall
    Genomics Division, Lawrence Berkeley National Laboratory, 1 Cycltotron Road MS 64 121, Berkeley, CA 94720, USA
    Genome Biol 13:R5. 2012
    ..It uses novel methods for representing taxonomic variation, and has proved to be essential for translational phenotype analyses. Uberon is available at http://uberon.org...
  52. ncbi More than just orphans: are taxonomically-restricted genes important in evolution?
    Konstantin Khalturin
    Zoological Institute, Christian Albrechts University Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    Trends Genet 25:404-13. 2009
    ..We propose that taxon-specific genes drive morphological specification, enabling organisms to adapt to changing conditions...
  53. pmc Genomewide SNP variation reveals relationships among landraces and modern varieties of rice
    Kenneth L McNally
    International Rice Research Institute, DAPO Box 7777, Metro Manila 1301, The Philippines
    Proc Natl Acad Sci U S A 106:12273-8. 2009
    ..These comprehensive SNP data provide a foundation for deep exploration of rice diversity and gene-trait relationships and their use for future rice improvement...
  54. ncbi Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
    C K Stover
    PathoGenesis Corporation, Seattle, Washington 98119, USA
    Nature 406:959-64. 2000
    ..We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances...
  55. pmc A classification of glycosyl hydrolases based on amino acid sequence similarities
    B Henrissat
    Centre de Recherches sur les Macromolecules Vegetales, C N R S, Grenoble, France
    Biochem J 280:309-16. 1991
    ..With the steady increase in sequence and structural data, it is suggested that the enzyme classification system should perhaps be revised...
  56. pmc The role of nucleosome positioning in the evolution of gene regulation
    Alexander M Tsankov
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
    PLoS Biol 8:e1000414. 2010
    ..Our study sheds light on the molecular basis of chromatin organization, and on the role of chromatin organization in the evolution of gene regulation...
  57. pmc Transcriptome analysis and comparison reveal divergence between two invasive whitefly cryptic species
    Xiao Wei Wang
    Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China
    BMC Genomics 12:458. 2011
    ..In this study, we sequenced the transcriptome of MEAM1 and took a comparative genomic approach to investigate the transcriptome evolution and the genetic factors underlying the differences between MEAM1 and MED...
  58. pmc Bayes estimation of species divergence times and ancestral population sizes using DNA sequences from multiple loci
    Bruce Rannala
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Genetics 164:1645-56. 2003
    ..Our estimates, however, are affected by model assumptions as well as data quality. We suggest that reliable estimates have yet to await more data and more realistic models...
  59. pmc The complete genome sequence of Mycobacterium bovis
    Thierry Garnier
    Unité de Génétique Moléculaire Bactérienne and PT4 Annotation, Genopole, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 100:7877-82. 2003
    ..bovis, implying that differential gene expression may be the key to the host tropisms of human and bovine bacilli. The genome sequence therefore offers major insight on the evolution, host preference, and pathobiology of M. bovis...
  60. ncbi 454 Pyrosequencing analyses of forest soils reveal an unexpectedly high fungal diversity
    M Buee
    INRA, UMR 1136 INRA Nancy Université Interactions Arbres Microorganismes, INRA Nancy, 54280 Champenoux, France
    New Phytol 184:449-56. 2009
    ..The large proportion of unidentified sequences, however, calls for curated sequence databases. The use of pyrosequencing on soil samples will accelerate the study of the spatiotemporal dynamics of fungal communities in forest ecosystems...
  61. pmc Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds
    Vincent J Munster
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 3:e61. 2007
    ..These data are useful for designing new surveillance programs and are particularly relevant due to increased interest in avian influenza in wild birds...
  62. pmc Sex-specific and lineage-specific alternative splicing in primates
    Ran Blekhman
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 20:180-9. 2010
    ....
  63. pmc Segmental structure of the Brassica napus genome based on comparative analysis with Arabidopsis thaliana
    Isobel A P Parkin
    Department of Agronomy, University of Wisconsin, Madison, 53706, USA
    Genetics 171:765-81. 2005
    ..The comparative map assists in exploiting the Arabidopsis genomic sequence for marker and candidate gene identification within the larger, intractable genomes of the Brassica polyploids...
  64. pmc DNA barcoding Australia's fish species
    Robert D Ward
    CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
    Philos Trans R Soc Lond B Biol Sci 360:1847-57. 2005
    ..We conclude that cox1 sequencing, or 'barcoding', can be used to identify fish species...
  65. pmc Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium
    Richard A Stabler
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Genome Biol 10:R102. 2009
    ..difficile (CD196), a recent epidemic and hypervirulent 027 (R20291) and a previously sequenced PCR-ribotype 012 strain (630)...
  66. ncbi The deep evolution of metazoan microRNAs
    Benjamin M Wheeler
    Department of Computer Science, North Carolina State University, Raleigh, NC 27695, USA
    Evol Dev 11:50-68. 2009
    ..We propose that miRNAs might be excellent phylogenetic markers, and suggest that the advent of morphological complexity might have its roots in miRNA innovation...
  67. ncbi Gene expression divergence recapitulates the developmental hourglass model
    Alex T Kalinka
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Nature 468:811-4. 2010
    ..These results indicate that natural selection acts to conserve patterns of gene expression during mid-embryogenesis, and provide a genome-wide insight into the molecular basis of the hourglass pattern of developmental evolution...
  68. pmc MiPred: classification of real and pseudo microRNA precursors using random forest prediction model with combined features
    Peng Jiang
    State Key Laboratory of Bioelectronics, Department of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, PR China
    Nucleic Acids Res 35:W339-44. 2007
    ..bioinf.seu.edu.cn/miRNA/. Given a sequence, MiPred decides whether it is a pre-miRNA-like hairpin sequence or not. If the sequence is a pre-miRNA-like hairpin, the RF classifier will predict whether it is a real pre-miRNA or a pseudo one...
  69. pmc DNA barcoding the floras of biodiversity hotspots
    Renaud Lahaye
    Department of Botany and Plant Biotechnology, APK Campus, University of Johannesburg, P O Box 524, Auckland Park 2006, Johannesburg, South Africa
    Proc Natl Acad Sci U S A 105:2923-8. 2008
    ....
  70. ncbi Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
    N T Perna
    Genome Center of Wisconsin, and Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA
    Nature 409:529-33. 2001
    ..These include candidate virulence factors, alternative metabolic capacities, several prophages and other new functions--all of which could be targets for surveillance...
  71. pmc Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals
    Debby van Riel
    Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
    Am J Pathol 171:1215-23. 2007
    Viral attachment to the host cell is critical for tissue and species specificity of virus infections...
  72. pmc Evolution of symbiotic bacteria in the distal human intestine
    Jian Xu
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 5:e156. 2007
    ....
  73. pmc Gene discovery and tissue-specific transcriptome analysis in chickpea with massively parallel pyrosequencing and web resource development
    Rohini Garg
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India
    Plant Physiol 156:1661-78. 2011
    ..Most importantly, the data and results reported in this study will help to accelerate research in various areas of genomics and implementing breeding programs in chickpea...
  74. ncbi The biology of speciation
    James M Sobel
    Department of Plant Biology and Ecology, Evolutionary Biology and Behavior Program, Michigan State University, East Lansing, Michigan 48824, USA
    Evolution 64:295-315. 2010
    ....
  75. ncbi The campaign to DNA barcode all fishes, FISH-BOL
    R D Ward
    CSIRO Wealth from Oceans Flagship, CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
    J Fish Biol 74:329-56. 2009
    ..However, current results indicate these issues are of little concern for the great majority of specimens...
  76. ncbi DNA barcoding for ecologists
    Alice Valentini
    Laboratoire d Ecologie Alpine, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
    Trends Ecol Evol 24:110-7. 2009
    ..Even DNA-based diet composition can be estimated using fecal samples. Here we review the new avenues offered to ecologists by DNA barcoding, particularly in the context of new sequencing technologies...
  77. pmc Comprehensive analysis of CpG islands in human chromosomes 21 and 22
    Daiya Takai
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 99:3740-5. 2002
    ..This finding is compatible with the recent detection of 5-methylcytosine in Drosophila, and might suggest that S. cerevisiae has, or once had, CpG methylation...
  78. pmc A two-locus global DNA barcode for land plants: the coding rbcL gene complements the non-coding trnH-psbA spacer region
    W John Kress
    Department of Botany, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States of America
    PLoS ONE 2:e508. 2007
    ..This low rate has complicated the trade-off in finding a locus that is universal and readily sequenced and has sufficiently high sequence divergence at the species-level...
  79. pmc Confirming the phylogeny of mammals by use of large comparative sequence data sets
    Arjun B Prasad
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1795-808. 2008
    ..g., in the case of Laurasiatheria), and demonstrate the valuable role that very large comparative sequence data sets can play in refining our understanding of the evolutionary relationships of vertebrates...
  80. pmc Regulatory divergence in Drosophila revealed by mRNA-seq
    C Joel McManus
    Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Genome Res 20:816-25. 2010
    ....
  81. pmc Deep sequencing reveals exceptional diversity and modes of transmission for bacterial sponge symbionts
    Nicole S Webster
    Australian Institute of Marine Science, PMB 3, Townsville Mail Centre, Qld 4810, Australia
    Environ Microbiol 12:2070-82. 2010
    ..Thus, members of the rare seawater biosphere may serve as seed organisms for widely occurring symbiont populations in sponges and their host association might have evolved much more recently than previously thought...
  82. pmc The frequency of polyploid speciation in vascular plants
    Troy E Wood
    Institute for Evolution and Biodiversity, University of Munster, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 106:13875-9. 2009
    ..Thus, the widespread occurrence of polyploid taxa appears to result from the substantial contribution of polyploidy to cladogenesis, but not from subsequent increases in diversification rates of polyploid lines...
  83. pmc Use of DNA barcodes to identify flowering plants
    W John Kress
    Department of Botany and Laboratories of Analytical Biology, National Museum of Natural History, Smithsonian Institution, P O Box 37012, Washington, DC 20013 7012
    Proc Natl Acad Sci U S A 102:8369-74. 2005
    ....
  84. pmc Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003
    K M Butt
    Department of Microbiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People s Republic of China
    J Clin Microbiol 43:5760-7. 2005
    ..The continued presence of H9N2 influenza viruses in poultry markets in southern China increases the likelihood of avian-to-human interspecies transmission...
  85. pmc Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000
    Helene Feil
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:11064-9. 2005
    ..The genomic comparison suggests that several unique genes for Pss B728a such as ectoine synthase, DNA repair, and antibiotic production may contribute to the epiphytic fitness and stress tolerance of this organism...
  86. pmc Forces shaping the fastest evolving regions in the human genome
    Katherine S Pollard
    Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America
    PLoS Genet 2:e168. 2006
    ..A combination of evolutionary forces has contributed to accelerated evolution of the fastest evolving elements in the human genome...
  87. pmc Human-specific loss of regulatory DNA and the evolution of human-specific traits
    Cory Y McLean
    Department of Computer Science, Stanford University, Stanford, California 94305, USA
    Nature 471:216-9. 2011
    ....
  88. ncbi A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle
    L Grobet
    Department of Genetics, Faculty of Veterinary Medicine, University of Liege, Belgium
    Nat Genet 17:71-4. 1997
    ..We report an 11-bp deletion in the coding sequence for the bioactive carboxy-terminal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle...
  89. pmc Host genetic background strongly influences the response to influenza a virus infections
    Barkha Srivastava
    Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    PLoS ONE 4:e4857. 2009
    ..The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses...
  90. ncbi High plant diversity is needed to maintain ecosystem services
    Forest Isbell
    Department of Biology, McGill University, Montreal, Quebec, H3A 1B1, Canada
    Nature 477:199-202. 2011
    ....
  91. pmc Comparative genomics of xylose-fermenting fungi for enhanced biofuel production
    Dana J Wohlbach
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 108:13212-7. 2011
    ..Several of these genes significantly improved xylose utilization when engineered into S. cerevisiae, demonstrating the power of comparative methods in rapidly identifying genes for biomass conversion while reflecting on fungal ecology...
  92. ncbi An evolutionary view of human recombination
    Graham Coop
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Nat Rev Genet 8:23-34. 2007
    ....
  93. ncbi Report of the ad hoc committee for the re-evaluation of the species definition in bacteriology
    Erko Stackebrandt
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany
    Int J Syst Evol Microbiol 52:1043-7. 2002
    ..The committee made various recommendations regarding the species definition in the light of developments in methodologies available to systematists...
  94. ncbi Evolutionary changes in cis and trans gene regulation
    Patricia J Wittkopp
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 430:85-8. 2004
    ..These data indicate that interspecific expression differences are not caused by select trans-regulatory changes with widespread effects, but rather by many cis-acting changes spread throughout the genome...
  95. pmc Two hybridization events define the population structure of Trypanosoma cruzi
    Scott J Westenberger
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Genetics 171:527-43. 2005
    ..The second hybridization between DTU IIb and IIc strains that generated DTUs IId and IIe resulted in extensive heterozygosity with subsequent recombination of parental genotypes...
  96. ncbi A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction
    Melvyn W Yap
    Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Curr Biol 15:73-8. 2005
    ..A single amino acid substitution (R332P) in the human Trim5alpha can confer the ability to restrict HIV-1, suggesting that small changes during evolution may have profound effects on our susceptibility to cross-species infection...
  97. ncbi Genealogical concordance between the mating type locus and seven other nuclear genes supports formal recognition of nine phylogenetically distinct species within the Fusarium graminearum clade
    Kerry O'Donnell
    National Center for Agricultural Utilization Research, US Department of Agriculture, Agricultural Research Service, Peoria, IL 61604, USA
    Fungal Genet Biol 41:600-23. 2004
    ..Species rank is formally proposed for the eight unnamed species within the Fg clade using fixed nucleotide characters...
  98. pmc Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition
    Vinita Joardar
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    J Bacteriol 187:6488-98. 2005
    ..With access to a fifth complete pseudomonad genome sequence, we were able to identify 3,567 ORFs that likely comprise the core Pseudomonas genome and 365 ORFs that are P. syringae specific...
  99. pmc Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice
    Adrianus C M Boon
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 83:10417-26. 2009
    ..One of the validated genes, the hemolytic complement gene, affected virus titer 7 days after infection. We conclude that H5N1 influenza virus-induced pathology is affected by a complex and multigenic host component...
  100. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
    ..albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis...
  101. pmc Polygenic and directional regulatory evolution across pathways in Saccharomyces
    James H Bullard
    Division of Biostatistics, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:5058-63. 2010
    ..We suggest that pathway analyses, including our test for directional regulatory evolution, will prove to be a relevant and powerful strategy in many evolutionary genomic applications...

Research Grants62

  1. Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic Acids
    Papasani V Subbaiah; Fiscal Year: 2013
    ....
  2. P. papatasi midgut molecules: gene function and assessing TBV candidates
    JOSE MARCELO contact RAMALHO ORTIGAO; Fiscal Year: 2010
    ....
  3. Role of innate immunity and injury in transplant-induced reactivation of MCMV
    Michael M Abecassis; Fiscal Year: 2013
    ..Due to the species specificity of HCMV, investigation of the factors that induce reactivation in transplant recipients has been hampered ..
  4. Mechanism of CCC DNA Synthesis in Hepatitis B Virus
    Christoph Seeger; Fiscal Year: 2013
    ..represent an exploratory effort that will set the stage for future investigations into he mechanism used by HBV to recruit the NER system and on the mechanism controlling the observed species specificity of HBV CCC DNA synthesis.
  5. MOLECULAR BIOLOGY AND PATHOGENESIS OF MOUSE ADENOVIRUS
    Katherine R Spindler; Fiscal Year: 2010
    ..A thorough knowledge of adenovirus basic biology is critical for the development of safe antiviral drugs, adenovirus-based gene transfer vectors, and vaccines. ..
  6. Charge Transfer Reactions of the Cytochrome bc1 Complex
    Colin A Wraight; Fiscal Year: 2011
    ..In addition, the bc1 complex is the target of many biocidal drugs, with significant species specificity and range...
  7. Triple action chimera: eradication of nasal S. aureus by cell wall hydrolases
    DAVID MATTHEW DONOVAN; Fiscal Year: 2010
    ..This study will explore a novel antimicrobial agent (a triple action chimeric viral enzyme) to eradicate S. aureus nasal colonization, since nasal carriage is a known risk factor for infection. ..
  8. Pathogenesis of Murine Polyomavirus Allograft Nephropathy
    Kenneth A Newell; Fiscal Year: 2012
    ..Due to the exquisite species specificity of Polyomaviridae, our understanding of the pathogenesis of BKV nephropathy (BKVN) following renal ..
  9. Crystal structures and mechanism of disease of the astrovirus capsid protein
    REBECCA MICHELLE DUBOIS; Fiscal Year: 2013
    ..I will identify the toxigenic domain and determine the structural basis for astrovirus antigenicity and species specificity. I will combine my expertise i structural biology and Dr...
  10. T-cell immunity to polyomavirus infection
    ARON LUKACHER; Fiscal Year: 2013
    ..No effective therapies for PyV infection are available. Due to the tight species specificity of Polyomaviridae that restricts infection to natural animal reservoirs, we have an incomplete ..
  11. Bordetella pathogenesis: an undergraduate research tool
    Louise M Temple; Fiscal Year: 2010
    ..revealed major differences in genes expected to encode cell surface structures that likely mediate the species specificity of this organism for avian tissues...
  12. Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine Disruption
    Kim Boekelheide; Fiscal Year: 2013
    ..This observation of species specificity in the testicular dysgenesis response raises two important questions addressed by this application: What ..
  13. Control of Symbiotic Gene Expression in Sinorhizobium meliloti
    Sharon R Long; Fiscal Year: 2013
    ..The interaction of bacterium and host plant is characterized by species specificity and by the complexity of a developmental process in which (1) the host build a root nodule, which is a ..
  14. Identification of compounds that activate interferon to treat viral infections
    Luis Martinez-Sobrido; Fiscal Year: 2011
    ..certify the compounds active in the primary screen as positive hits by secondary assays, evaluating their species specificity, mechanism of action and toxicity in order to prioritize their characterization in antiviral assays...
  15. Role of Cytomegalovirus GPCRs in Pathogenesis in Vivo
    William E Miller; Fiscal Year: 2012
    ..The strict species specificity of HCMV has precluded an analysis of the function of HCMV GPCRs in vivo...
  16. Mechanism of Staphylocoagulase-activated Blood Clotting
    Paul E Bock; Fiscal Year: 2012
    ..studies will test the hypothesis that autolysis loop residues of human and bovine ProT control the species specificity of SC-ProT activation...
  17. STAT4 mediated immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2012
    ..The lack of the ability to culture Pneumocystis in vitro coupled with high species specificity has limited investigations into human CD4 T cell mediated responses to Pneumocystis...
  18. Studies in Poxvirus Host Range Genes and Tropism
    Grant McFadden; Fiscal Year: 2013
    Project Summary We propose to examine the molecular pathways that mediate the species specificity and tropism of one particular poxvirus, namely myxoma virus (MV)...
  19. Modulation of adenovirus pathogenesis by prostaglandin E2
    JASON BRICE WEINBERG; Fiscal Year: 2013
    ..Studies of human adenovirus pathogenesis are limited by the strict species specificity of the adenoviruses...
  20. Viral evasion of NK cells
    Stipan Jonjic; Fiscal Year: 2012
    ..Cytomegaloviruses (CMV) are characterized by strict species specificity. Infection of mice with mouse CMV (MCMV) has been particularly informative as a model of HCMV infection in ..
  21. Adenovirus myocarditis: defining host factors contributing to pathogenesis
    JASON BRICE WEINBERG; Fiscal Year: 2013
    ..between myocarditis and infection with human adenoviruses (Ad) have been well established, but strict species specificity limits studies of human adenovirus pathogenesis...
  22. Priming and fusion activation of the SARS coronavirus spike glycoprotein
    Gary R Whittaker; Fiscal Year: 2010
    ....
  23. Vaccine against CMV endothelial tropism &congenital infection
    Alistair McGregor; Fiscal Year: 2013
    ..The studies will be carried out using guinea pig cytomegalovirus (GPCMV) because of species specificity of HCMV...
  24. Oral Colonization of Aggregatibacter in Primates
    Daniel H Fine; Fiscal Year: 2012
    ..specificity of Aa attachment to epithelium and have shown that these adhesins (as well as Leukotoxin) show species specificity for Old World (OW) primates and humans...
  25. DRUG ABUSE AND REGULATORY ENZYMES OF BIOGENIC AMINES
    ANNETTE FLECKENSTEIN; Fiscal Year: 2010
    ..of METH-induced DAT complex formation;3) if transporter complex formation is unique to DA neurons;4) the species specificity of METH-induced DAT complex formation;5) if DAT complex formation is a unique consequence of METH treatment;..
  26. Allelic variants of Salmonella fimbrial adhesins
    Dieter M Schifferli; Fiscal Year: 2013
    ..be used to test our hypothesis that specific Salmonella adhesins and their allelic variants determine host species specificity and facilitate HGT...
  27. Genomics of mosquito resistance to Plasmodium
    Kenneth D Vernick; Fiscal Year: 2012
    ..Knowledge of the genetic mechanisms that affect transmission of malaria by vector mosquitoes would aid in the development of such vector-based control strategies. ..
  28. Identifying species-specific anti-malarial Hsp90 inhibitors using genetically eng
    Luke J Whitesell; Fiscal Year: 2012
    ..Additionally, hits from the test set show the desired species specificity and provide excellent proof of concept. Secondary assays will include testing hit compounds against P...
  29. Bioluminescent reporter phage for the diagnostic detection of shigellosis
    David A Schofield; Fiscal Year: 2013
    ..Aim 1 will identify and prioritize Shigella phages which display species specificity and broad strain infectivity...
  30. CHARACTERIZATION OF THE AH RECEPTOR SIGNALING PATHWAY
    Christopher A Bradfield; Fiscal Year: 2011
    ..First, identifying modifiers of AHR signaling will help explain the tissue and species specificity of dioxin toxicity and thus will aid attempts to predict the human and environmental risk that results from ..
  31. Towards Understanding the Morbidity of HEV Infection
    Mohamed Tarek Shata; Fiscal Year: 2007
    ..The four genotypes of HEV are cross-reactive serologically but have different geographical distributions, species specificity, and virulence. However, cross-species infections have been reported...
  32. The role of gammaherpesvirus protein kinase in lytic and latent infection
    Vera L Tarakanova; Fiscal Year: 2010
    ..Unfortunately, the exquisite species specificity of EBV and KSHV limits investigations of primary infection and long term virus-host interactions in vivo...
  33. SPECIES-SPECIFIC DNA PROBES FOR BANCROFTIAN FILARIASIS
    Steven Williams; Fiscal Year: 1990
    ..bancrofti in human blood and in mosquitoes. Finally, these probes will need to be tested in field studies conducted in endemic regions of Egypt...
  34. A novel NKG2D-specific BiTE cancer immunotherapy
    Charles L Sentman; Fiscal Year: 2013
    ..Because of the species specificity of these molecules, we can use these other versions as control proteins...
  35. CHEMICAL EFFECTS ON METABOLISM AND REPRODUCTION
    Mary Haasch; Fiscal Year: 2001
    ..The proposed investigation will provide insight into cell signaling cross-talk between metabolic pathways and nuclear hormone receptors, endocrine disruption, and the developmental and reproductive effects of PAPAS. ..
  36. CHARACTERIZATION OF BORDETELLA AVIUM ATTACHMENT FACTORS
    Louise Temple; Fiscal Year: 2000
    ..pertussis. Species specificity is determined largely by the attachment process of the bacteria to the tracheal cilia of the relevant host...
  37. ASPARAGINYL TRNA SYNTHETASE OF BRUGIA MALAYI
    Michael Kron; Fiscal Year: 2001
    ....
  38. MAMMALIAN SPERM SURFACE MANNOSIDASE
    DAULAT TULSIANI; Fiscal Year: 2003
    ....
  39. SARS Coronavirus Reverse Genetics and Pathogenesis
    PAUL MASTERS; Fiscal Year: 2005
    ..This system has been used to answer fundamental questions about viral protein structure and function, host species specificity, virion assembly, and the unusually complex mechanism of coronavirus genome RNA synthesis...
  40. MOLECULAR GENETICS OF YEAST SEXUAL AGGLUTININS
    JANET KURJAN; Fiscal Year: 1999
    ..cerevisiae agglutinins; however agglutinin interactions show species specificity. The cloning of agglutinin structural genes from the yeast S...
  41. INVESTIGATE THE REGULATION OF BONE RESORPTION
    Timothy Chambers; Fiscal Year: 1991
    ..to test the responsiveness of human osteoclasts, particularly to cytokines and growth factors that show species specificity. The tumors also represent a bulk of osteoclasts otherwise unavailable in mammals, from which we propose to ..
  42. ENDOTHELIAL CELL IN CORONARY VASOSPASM AND THROMBOSIS
    ROBERT HIGHSMITH; Fiscal Year: 1992
    ..We have examined species specificity, its effect in isolated VSM cells, beating heart preparations and in whole animal vasculatures...
  43. CMV LABYRINTHITIS INDUCED IN IMMUNODEFICIENT SCID MICE
    NIGEL WOOLF; Fiscal Year: 2004
    ....
  44. ANIMAL BRUCELLOSIS: DIAGNOSTIC CONTROL METHODS
    LELAND CARMICHAEL; Fiscal Year: 1980
    ..An antigen designated "2R" has the greatest species specificity for B. canis; two closely related rough brucellae (B. ovis and B...
  45. Host range and pathogenesis of paramyxoviruses
    Toru Takimoto; Fiscal Year: 2007
    ..These results led us to hypothesize that species specificity of viral anti-IFN activity restrict the host range of type 1parainfluenza viruses...
  46. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
    ..Results will help in defining the mechanism(s) of fumonisin toxicity, causes of species-specificity, and provide a better appraisal of risk in humans, including modification of fumonisin response by gram-negative infections. ..
  47. NICOTINE REGULATION OF DEVELOPING BRAIN CATECHOLAMINES
    Frances Leslie; Fiscal Year: 2005
    ..We will study the species specificity of nAChR-mediated catecholamine release in C57BL/6J mice, and will use null mutant mouse strains to examine ..
  48. DIVERSITY AND PATHOGENESIS OF SIVAGM
    Yen Li; Fiscal Year: 1993
    ..The other is to determine whether viral and /or host factors are important in pathogenesis and species specificity of these viruses...
  49. MOLECULAR ANALYSIS OF STAPHYLOCOCCAL EXFOLIATIVE TOXIN A
    LISA PLANO; Fiscal Year: 2007
    ..Results from these analyses will provide insight into the mechanism for the age and species specificity of this unique serine protease...
  50. Novel Strategy for Animal Model Testing of HCMV Vaccines
    Mark Schleiss; Fiscal Year: 2007
    ..These studies will represent the first efficacy test of a human CMV subunit vaccine in a small animal model of congenital CMV infection. [unreadable] [unreadable]..
  51. GENETICS OF HOST-SPECIFIC INFECTION BY RHIZOBIA
    Gary Stacey; Fiscal Year: 1990
    ..An interesting feature of this process is the species specificity exhibited (i.e., only certain species of rhizobia will infect certain species of plants)...
  52. PLANT TRANSCRIPTION FACTORS AND RNA POLYMERASES
    THOMAS GUILFOYLE; Fiscal Year: 1993
    ..In addition, the isolation of these genes will provide specific probes for studying the regulation of RNA polymerase gene expression...
  53. PLASMODIUM VIVAX NON-CS SPOROZOITE PROTEINS
    Barbara Sina; Fiscal Year: 1993
    ..falciparum and P. berghei sporozoites. During the course of studying the species specificity of CSP-2, two novel P. vivax sporozoite non-CS proteins were detected. An anti-P...
  54. COMPARATIVE STUDIES OF SOMATOMEDIN AND INSULIN RECEPTORS
    Ron Rosenfeld; Fiscal Year: 1991
    ..will be employed, together with competitive binding and affinity cross-linking, to determine tissue and species specificity of the receptors, ontogeny of each receptor, and receptor phosphorylation and kinase activity...
  55. TARGET-BASED SCREENS FOR NOVEL nAChR INSECTICIDES
    SCOTT CHOUINARD; Fiscal Year: 2005
    ..abstract_text> ..
  56. ENDOPLASMIC RETICULUM OF TRYPANOSOMATIDS
    Kojo Mensa Wilmot; Fiscal Year: 2003
    ....
  57. SV40 T ANTIGEN TRANSACTIVATION AND TRANSFORMATION
    JANE CAVENDER; Fiscal Year: 2005
    ....
  58. IDENTIFICATION OF HUMAN LYMPHOCYTE SURFACE ANTIGENS
    Ian Trowbridge; Fiscal Year: 1980
    ..Since lymphoid antigens show a high degree of species specificity, attempts will be made to raise large quantities of effectively monospecific antisera against the human ..
  59. GENETICS OF RADIATION RESISTANCE
    William McKenna; Fiscal Year: 1992
    ..The karyotypic changes induced by oncogene transfection will be correlated with the radioresistant phenotype. The species specificity of oncogene induced radioresistance will be explored.
  60. STRUCTURAL STUDIES OF SARS AND MHV REPLICASE PROTEINS
    L Schultz; Fiscal Year: 2005
    ..by the comparison of SARS-CoV and MHV will be instrumental in understanding biological differences such as species specificity (human vs...
  61. TUMOR NECROSIS FACTOR AND IRON METABOLISM
    FRANK TORTI; Fiscal Year: 2000
    ..direct introduction into cells of our ferritin recombinant proteins with different H/L subunit ratios and species specificity. In these systems, we will assess the effect of alterations in ferritin composition and content on the ..
  62. HUMAN SKELETAL MUSCLE MYOSIN ISOFORM IN HEALTH & DISEASE
    JUDITH SAWCHAK; Fiscal Year: 1990
    ..Their specificity will be characterized as to species specificity, heavy versus light chain specificity, subfragment and macromolecular location of recognized epitope, as ..