skin aging

Summary

Summary: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.

Top Publications

  1. ncbi Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin
    Meghan Brennan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Photochem Photobiol 78:43-8. 2003
  2. ncbi Esthetic and cosmetic dermatology
    Uwe Wollina
    Department of Dermatology and Allergology, Hospital Dresden Friedrichstadt, Dresden, Germany
    Dermatol Ther 21:118-30. 2008
  3. ncbi Mechanisms of photoaging and chronological skin aging
    Gary J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Dermatol 138:1462-70. 2002
  4. ncbi UV-light-induced signal cascades and skin aging
    Laure Rittie
    Department of Dermatology, University of Michigan, 1150 West Medical Center Drive, R6447 Medical Science I, Ann Arbor, MI 48109 0609, USA
    Ageing Res Rev 1:705-20. 2002
  5. pmc Regulation of skin aging and heart development by TAp63
    M Paris
    L Oreal Recherche, Clichy, France
    Cell Death Differ 19:186-93. 2012
  6. ncbi Clinical aspects and molecular diagnostics of skin aging
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Clin Dermatol 29:3-14. 2011
  7. ncbi Modulation of skin collagen metabolism in aged and photoaged human skin in vivo
    J H Chung
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
    J Invest Dermatol 117:1218-24. 2001
  8. pmc Looking older: fibroblast collapse and therapeutic implications
    Gary J Fisher
    Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0609, USA
    Arch Dermatol 144:666-72. 2008
  9. pmc Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin
    Gary J Fisher
    Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan 48109 5609, USA
    Am J Pathol 174:101-14. 2009
  10. ncbi Photoageing: mechanism, prevention and therapy
    M Yaar
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118 2394, USA
    Br J Dermatol 157:874-87. 2007

Detail Information

Publications276 found, 100 shown here

  1. ncbi Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin
    Meghan Brennan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Photochem Photobiol 78:43-8. 2003
    ..These findings strongly implicate MMP-1 rather than MMP-13 as the major collagenolytic enzyme responsible for collagen damage in photoaging...
  2. ncbi Esthetic and cosmetic dermatology
    Uwe Wollina
    Department of Dermatology and Allergology, Hospital Dresden Friedrichstadt, Dresden, Germany
    Dermatol Ther 21:118-30. 2008
    ....
  3. ncbi Mechanisms of photoaging and chronological skin aging
    Gary J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Dermatol 138:1462-70. 2002
    ..The primary environmental factor that causes human skin aging is UV irradiation from the sun...
  4. ncbi UV-light-induced signal cascades and skin aging
    Laure Rittie
    Department of Dermatology, University of Michigan, 1150 West Medical Center Drive, R6447 Medical Science I, Ann Arbor, MI 48109 0609, USA
    Ageing Res Rev 1:705-20. 2002
    ..Thus, skin aging is associated with increased AP-1 activity, increased MMP expression, impaired TGF-beta signaling, enhanced ..
  5. pmc Regulation of skin aging and heart development by TAp63
    M Paris
    L Oreal Recherche, Clichy, France
    Cell Death Differ 19:186-93. 2012
    ..Interestingly, in both cases, TAp63 acts in a cell-nonautonomous manner on adjacent cells. Here, we discuss these findings and their potential connection during development...
  6. ncbi Clinical aspects and molecular diagnostics of skin aging
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Clin Dermatol 29:3-14. 2011
    ..and studies of progeroid syndromes illustrate that among the most important biologic processes involved in skin aging are alterations in DNA repair and stability, mitochondrial function, cell cycle and apoptosis, extracellular ..
  7. ncbi Modulation of skin collagen metabolism in aged and photoaged human skin in vivo
    J H Chung
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
    J Invest Dermatol 117:1218-24. 2001
    ..Thus, the balance between collagen synthesis and degradation leading to collagen deficiency is different in photoaged and naturally aged skin...
  8. pmc Looking older: fibroblast collapse and therapeutic implications
    Gary J Fisher
    Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0609, USA
    Arch Dermatol 144:666-72. 2008
    ..During the last decade, substantial progress has been made toward understanding underlying mechanisms of human skin aging. This understanding provides the basis for current use and new development of antiaging treatments...
  9. pmc Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin
    Gary J Fisher
    Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan 48109 5609, USA
    Am J Pathol 174:101-14. 2009
    ..We propose that this self perpetuating cycle promotes human skin aging. These data extend the current understanding of the oxidative theory of aging beyond a cellular-centric view to ..
  10. ncbi Photoageing: mechanism, prevention and therapy
    M Yaar
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118 2394, USA
    Br J Dermatol 157:874-87. 2007
    ..Such advances should not only allow for the improved appearance of skin in middle age and beyond, but also greatly reduce the accompanying burden of skin cancer...
  11. pmc Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation
    James Varani
    Department of Pathology, The University of Michigan, 1301 Catherine Rd Box 0602, Ann Arbor, MI 48109 USA
    Am J Pathol 168:1861-8. 2006
    ..Based on the findings presented here, we conclude that reduced collagen synthesis in chronologically aged skin reflects at least two different underlying mechanisms: cellular fibroblast aging and a lower level of mechanical stimulation...
  12. ncbi Photoaging of the skin from phenotype to mechanisms
    K Scharffetter-Kochanek
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931, Cologne, Germany
    Exp Gerontol 35:307-16. 2000
    ..A decrease in the overall ROS load by efficient sunscreens or other protective agents may represent promising strategies to prevent or at least minimize ROS induced photoaging...
  13. ncbi Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice
    Ayako Hirota
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Exp Dermatol 20:664-8. 2011
    ..These findings indicate that Nrf2 plays the important role in the protection against UVB-induced photoageing...
  14. pmc Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Pathol 165:741-51. 2004
    ..This reduction is a key feature of the pathophysiology of premature skin aging (photoaging). Photoaging is the most common form of skin damage and is associated with skin carcinoma...
  15. ncbi Skin ageing
    J Calleja-Agius
    Department of Obstetrics and Gynaecology, St Luke s Hospital, Malta
    Menopause Int 13:60-4. 2007
    ..Large-scale clinical trials are necessary to help make informed recommendations regarding postmenopausal estrogen use and its role in the prevention of skin ageing...
  16. ncbi Weathering of the hairless scalp: a study using skin capacitance imaging and ultraviolet light-enhanced visualization
    E Xhauflaire-Uhoda
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Clin Exp Dermatol 35:83-5. 2010
    ..The induced changes are better revealed under ultraviolet light examination. Any alteration in the epidermal maturation is potentially reflected by stratum corneum changes observed as disturbances on skin-capacitance imaging...
  17. ncbi Time to onset of response of abobotulinumtoxina in the treatment of glabellar lines: a subset analysis of phase 3 clinical trials of a new botulinum toxin type A
    Joel Schlessinger
    Advanced Skin Research, Omaha, Nebraska 68144, USA
    Dermatol Surg 37:1434-42. 2011
    ..OBJECTIVE To determine onset of response based on participant assessments recorded from days 1 through 7...
  18. ncbi Nested self-similar wrinkling patterns in skins
    Kirill Efimenko
    Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695 7905, USA
    Nat Mater 4:293-7. 2005
    ..In particular, we show how to use the multigeneration-wrinkled substrate for separating particles based on their size, while simultaneously forming linear chains of monodisperse particles...
  19. ncbi Skin aging from ultraviolet irradiance and smoking reduces risk of melanoma: epidemiological evidence
    William B Grant
    CSunlight, Nutrition, and Health Research Center SUNARC, P O Box 641603, San Francisco, CA 94164 1603, USA
    Anticancer Res 28:4003-8. 2008
    ..74. Smoking increases skin aging or elastosis in a manner similar to that of UV irradiance...
  20. doi Changes in glycosaminoglycans and related proteoglycans in intrinsically aged human skin in vivo
    Jang Hee Oh
    Exp Dermatol 20:454-6. 2011
    ..Versican stain was increased in male aged skin, but not in female. Age- and gender-related changes in GAGs and PGs in intrinsically aged buttock skin elucidated in this study may play important roles in intrinsic skin ageing process...
  21. ncbi Intrinsic aging- and photoaging-dependent level changes of glycosaminoglycans and their correlation with water content in human skin
    Jang Hee Oh
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Dermatol Sci 62:192-201. 2011
    ..Glycosaminoglycans (GAGs) have various structural and physiological regulatory functions in skin, including tissue water maintenance, due to their high water-holding capacity...
  22. ncbi Bioactive compounds from natural resources against skin aging
    Pulok K Mukherjee
    School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
    Phytomedicine 19:64-73. 2011
    b>Skin aging involves degradation of extracellular matrix (ECM) in both the epidermal and dermal layers, it leaves visible signs on the surface of skin and the physical properties of the skin are modified...
  23. ncbi Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin
    J Varani
    Departments of Pathology and Dermatology, The University of Michigan, Medical School, Ann Arbor, MI 48109, USA
    J Invest Dermatol 114:480-6. 2000
    ..is believed to underlie changes associated with both photoaging and natural aging, we determined whether natural skin aging, like photoaging, gives rise to increased matrix metalloproteinases and reduced collagen synthesis...
  24. ncbi Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
    J Invest Dermatol 117:219-26. 2001
    ..Although ultraviolet irradiation induces both MMP-1 and MMP-8, ultraviolet-induced collagen degradation is initiated primarily by MMP-1, with little, if any, contribution by MMP-8...
  25. pmc Why some women look young for their age
    David A Gunn
    Unilever Discover, Sharnbrook, Bedfordshire, United Kingdom
    PLoS ONE 4:e8021. 2009
    ..The findings also demonstrate that perceived age is a better biomarker of skin, hair and facial aging than chronological age...
  26. ncbi The skin as a mirror of the aging process in the human organism--state of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)
    Evgenia Makrantonaki
    Departments of Dermatology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Exp Gerontol 42:879-86. 2007
    ..Thus, these results could be a basis for an integrated and interdisciplinary approach to the analysis of the aging process...
  27. ncbi Molecular mechanisms of skin ageing
    Gail Jenkins
    Unilever R and D Colworth, Biosciences Division, Sharnbrook, Bedford, UK
    Mech Ageing Dev 123:801-10. 2002
    ..As these mechanisms are identified, further insights into the underlying processes of skin ageing should emerge and better strategies to prevent the undesirable effects of age on skin appearance should follow...
  28. ncbi Regulatory roles of sex hormones in cutaneous biology and immunology
    Naoko Kanda
    Department of Dermatology, School of Medicine, Teikyo University, 11 1, Kaga 2, Itabashi ku, Tokyo 173 8605, Japan
    J Dermatol Sci 38:1-7. 2005
    ..These regulatory effects of sex steroids may be manipulated as therapeutic or prophylactic measures in psoriasis, aging, chronic wounds or granuloma pyogenicum...
  29. ncbi Biology of estrogens in skin: implications for skin aging
    Sylvie Verdier-Sévrain
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    Exp Dermatol 15:83-94. 2006
    ..Estrogens clearly have a key role in skin aging homeostasis as evidenced by the accelerated decline in skin appearance seen in the perimenopausal years...
  30. ncbi Expression profiling of aging in the human skin
    Thomas Lener
    Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    Exp Gerontol 41:387-97. 2006
    ..These results suggest that the aging process in the human skin is connected with the deregulation of various cellular processes, like cell cycle control, cytoskeletal changes, inflammatory response, signaling and metabolism...
  31. ncbi Photoaging: mechanisms and repair
    Jessica H Rabe
    Department of Dermatology, Johns Hopkins University, USA
    J Am Acad Dermatol 55:1-19. 2006
    ..The focus of this review is the mechanism of photoaging and the pathophysiology underlying the treatments specifically designed for its prevention and treatment...
  32. ncbi Skin ageing: a comparison between Chinese and European populations. A pilot study
    S Nouveau-Richard
    L Oreal Recherche, Centre Charles Zviak, 90 rue du General Roguet, 92583 Clichy, France
    J Dermatol Sci 40:187-93. 2005
    ..Although limited data are available, it is commonly considered that Europeans and Asians have different skin ageing features...
  33. ncbi Factors of skin ageing share common mechanisms
    P U Giacomoni
    Clinique Laboratories, Melville NY 11747, USA
    Biogerontology 2:219-29. 2001
    ..This closes a self-maintained micro-inflammatory cycle, which results in the accumulation of ECM damage, i.e. skin aging. In this paper we review the evidence that two factors able to induce macroscopical and molecular modifications ..
  34. ncbi Psychosocial aspects of aging skin
    Madhulika A Gupta
    Department of Psychiatry, University of Western Ontario, London, Canada
    Dermatol Clin 23:643-8. 2005
    ..Patients should therefore be offered treatments for aging skin, ensured that society's negative views not be unnecessarily reinforced, and maintain a realistic treatment expectations...
  35. ncbi The role of telomeres in skin aging/photoaging
    M G Kosmadaki
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118 2394, USA
    Micron 35:155-9. 2004
    Recent work has substantially elucidated the mechanisms of skin aging and photoaging. In particular, a central role for telomere-based signaling can be inferred...
  36. ncbi Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice
    Tong Ho Kang
    Department of Oriental Medicinal Materials and Processing, College of Life Sciences, Kyung Hee University, Global Campus, Seocheon dong, Giheung gu, Yongin si, Gyeonggi Do 446 701, Republic of Korea
    J Ethnopharmacol 123:446-51. 2009
    ..Panax ginseng C.A. Meyer, Korean herb medicine, has been widely used in China and Japan for fatigue and enhancement of resistance to many diseases...
  37. pmc Anti-photoaging and photoprotective compounds derived from marine organisms
    Ramjee Pallela
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 8:1189-202. 2010
    ..The present review depicts various other photoprotective compounds from algae and other marine sources for further elaborative research and their probable use in cosmeceutical and pharmaceutical industries...
  38. pmc Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro
    J Varani
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Rd Box 0602, Ann Arbor, MI 48109, USA
    Am J Pathol 158:931-42. 2001
    ....
  39. ncbi UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging
    Eun Ju Kim
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Dermatol Sci 57:19-26. 2010
    ..Although fatty acids are known to be important in various skin functions, their roles on photoaging in human skin are poorly understood...
  40. ncbi Oxidative damage, skin aging, antioxidants and a novel antioxidant rating system
    Debbie M Palmer
    White Plains Hospital, Department of Medicine, White Plains, NY, USA
    J Drugs Dermatol 9:11-5. 2010
    ..Together, intrinsic and extrinsic damage are the primary causes of skin aging. The skin uses a series of intrinsic antioxidants to protect itself from free radical damage...
  41. ncbi Potential protective effect of fresh grown unicellular green algae component (resilient factor) against PMA- and UVB-induced MMP1 expression in skin fibroblasts
    Mei Fen Shih
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, 60 Erh Jen Road, Sec 1, Pao An, Jen Te Hsiang, Tainan, 717, Taiwan ROC
    Eur J Dermatol 18:303-7. 2008
    ..In addition, RF prevents the UVB-suppressed elastin protein and pro-collagen gene expression. These findings indicate that RF may exert a protective effect against UVB irradiation-induced damage in the skin...
  42. pmc Age-related differences in human skin proteoglycans
    David A Carrino
    Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Glycobiology 21:257-68. 2011
    ..These age-related differences in proteoglycan patterns and catabolism may play a role in the age-related changes in the physical properties and injury response of human skin...
  43. ncbi Retinal branch artery occlusion following injection of hyaluronic acid (Restylane)
    Silvia Peter
    Department of Ophthalmology, Academic Teaching Hospital, Feldkirch, Austria
    Clin Experiment Ophthalmol 34:363-4. 2006
    ..If there is any evidence of a visual problem after facial injection of a dermal filler, prompt consultation of an ophthalmologist is recommended...
  44. ncbi Noninferiority of incobotulinumtoxinA, free from complexing proteins, compared with another botulinum toxin type A in the treatment of glabellar frown lines
    Gerhard Sattler
    Rosenpark Klinik, Darmstadt, Germany
    Dermatol Surg 36:2146-54. 2010
    ..Use of botulinum toxin for esthetic purposes has rapidly expanded over the last 20 years. IncobotulinumtoxinA, also known as NT 201, is a new botulinum toxin type A (150 kDa) that is free from complexing proteins...
  45. ncbi Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells
    Thanyawan Pluemsamran
    Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Photochem Photobiol 88:961-8. 2012
    Ultraviolet A (UVA) plays a vital role in the pathogenesis of premature skin aging through keratinocyte cytotoxicity and degradation of collagen, a main component of the extracellular matrix providing structural support...
  46. ncbi Ultrasonographic assessment of skin structure according to age
    Diana Crisan
    Department of Histology, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Indian J Dermatol Venereol Leprol 78:519. 2012
    ..High-frequency ultrasound is a noninvasive tool that offers characteristic markers, quantifying the cutaneous changes of the physiological senescence process...
  47. ncbi Ageing and photoageing of keratinocytes and melanocytes
    M Yaar
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA
    Clin Exp Dermatol 26:583-91. 2001
    ..photoaged skin are delineated. Mutations that are found in malignant and premalignant tumors of epidermal origin are described...
  48. ncbi Short review on face rejuvenation procedures: focus on preoperative antiseptic and anesthetic delivery by JetPeel™-3 (a high pressure oxygen delivery device)
    T Iannitti
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, UK
    Minerva Chir 66:1-8. 2011
    ..The aim of this study was to assess the device efficacy starting from a short review on face rejuvenation procedures...
  49. ncbi A serial analysis of gene expression in sun-damaged human skin
    Johann Urschitz
    The Pacific Biomedical Research Center, University of Hawaii, 1993 East West Road, Honolulu, HI 96822, U S A
    J Invest Dermatol 119:3-13. 2002
    ..These results suggest a major role for the epidermis in the pathomechanism of largely dermal changes in chronically sun-exposed skin...
  50. ncbi Non-sequential fractional ultrapulsed CO2 resurfacing of photoaged facial skin: preliminary clinical report
    Matteo Tretti Clementoni
    Dipartimento di Laser e Chirurgia, Istituto Dermatologico Europeo, Milano, Italy
    J Cosmet Laser Ther 9:218-25. 2007
    ..Minimal and isolated adverse side effects were noted and the downtime was very low. Non-sequential fractional ultrapulsed CO2 light treatment ('ActiveFX') can be considered an excellent alternative for photodamaged facial skin...
  51. ncbi Treatment of glabellar lines with botulinum toxin type A (Speywood Unit): a clinical overview
    B Rzany
    dEBM, Klinik fur Dermatologie, Charite Universitatsmedizin, Berlin, Germany
    J Eur Acad Dermatol Venereol 24:1-14. 2010
    ..The efficacy and safety profiles reported here are unique to BoNT-A (s.U) and cannot be generalized to other BoNT-A products...
  52. ncbi Main approaches for delivering antioxidant vitamins through the skin to prevent skin ageing
    Mirjana Gasperlin
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia
    Expert Opin Drug Deliv 8:905-19. 2011
    ..Successful prophylaxis and therapy would necessitate control of the oxidant/antioxidant balance at the affected site, which can be achieved through the external supply of endogenous antioxidants...
  53. ncbi Antibody-induced failure of botulinum toxin a therapy in cosmetic indications
    Dirk Dressler
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Dermatol Surg 36:2182-7. 2010
    ..Botulinum toxin (BT) is a safe and effective treatment for cosmetic indications. Formation of BT antibodies can occur but has previously been reported in cosmetic indications in two cases only...
  54. ncbi The gene expression profile of psoralen plus UVA-induced premature senescence in skin fibroblasts resembles a combined DNA-damage and stress-induced cellular senescence response phenotype
    Celine Borlon
    Research Unit on Cellular Biology URBC, Department of Biology, University of Namur FUNDP, rue de Bruxelles, 61, B 5000 Namur, Belgium
    Exp Gerontol 42:911-23. 2007
    ....
  55. ncbi Rapid onset of response and patient-reported outcomes after onabotulinumtoxinA treatment of moderate-to-severe glabellar lines
    Kenneth R Beer
    Palm Beach Esthetic Center, West Palm Beach, FL 33401, USA
    J Drugs Dermatol 10:39-44. 2011
    ..no previously published botulinum toxin type A cosmetic trials included both physician and subject measures of onset...
  56. ncbi Skin aging
    Neira Puizina-Ivic
    Department of Dermatovenerology, Split Clinical Hospital Center, Soltanska 1, 21 000 Split, Croatia
    Acta Dermatovenerol Alp Pannonica Adriat 17:47-54. 2008
    There are two main processes that induce skin aging: intrinsic and extrinsic...
  57. ncbi Photorejuvenation for Asian skin by intense pulsed light
    K Negishi
    Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan
    Dermatol Surg 27:627-31; discussion 632. 2001
    ..CONCLUSION: Photorejuvenation using IPL is a completely safe and effective procedure even for Asian skin. It will be increasingly used for skin rejuvenation in the future...
  58. ncbi Oral isotretinoin as part of the treatment of cutaneous aging
    E Hernandez-Perez
    Center for Dermatology and Cosmetic Surgery, San Salvador, El Salvador
    Dermatol Surg 26:649-52. 2000
    ..A number of drugs have been used to prevent aging changes. However, studies of oral isotretinoin, the commonly used acne drug, as an antiaging drug are lacking...
  59. ncbi H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo
    Mi Hee Shin
    Department of Dermatology, Laboratory of Cutaneous Agining Research, Clinical Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Invest Dermatol 125:221-9. 2005
    ..due to catalase attenuation may be a critical aspect of the MAP kinase signaling changes that may lead to skin aging and photoaging in human skin in vivo...
  60. ncbi Nonablative skin remodeling: selective dermal heating with a mid-infrared laser and contact cooling combination
    E V Ross
    Department of Dermatology, Naval Medical Center San Diego, San Diego, California 92134, USA
    Lasers Surg Med 26:186-95. 2000
    ..Accordingly, we investigated the clinical and microscopic changes produced by a mid-infrared laser coupled with a contact cooling device...
  61. ncbi Reconstructed skin modified by glycation of the dermal equivalent as a model for skin aging and its potential use to evaluate anti-glycation molecules
    Hervé Pageon
    L Oreal, Life Sciences Advanced Research, Centre Charles Zviak, 90 rue du General Roguet, 92583 Clichy, France
    Exp Gerontol 43:584-8. 2008
    ..In conclusion the glycation inhibitory effect has been functionally demonstrated in the reconstructed skin model and it is shown that this model can be used to assess anti-glycation agents...
  62. ncbi Long-term results for incobotulinumtoxinA in the treatment of glabellar frown lines
    Berthold Rzany
    Division of Evidence Based Medicine, Klinik fur Dermatologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Dermatol Surg 39:95-103. 2013
    ....
  63. ncbi Virgin olive oil as a fundamental nutritional component and skin protector
    Publio Viola
    Olive National Academy, Piazza della Libertà 12, Spoleto, PG 06049, Italy
    Clin Dermatol 27:159-65. 2009
    ..Therefore, an evaluation of the biologic value of extra virgin olive oil and its use as a topical raw material in cosmetic dermatology is reported...
  64. ncbi Overview of skin aging and photoaging
    Yolanda Rosi Helfrich
    Department of Dermatology, University of Michigan, Ann Arbor, MI, USA
    Dermatol Nurs 20:177-83; quiz 184. 2008
    ..Aging skin is an issue of concern to many patients. In this review aging and photoaging are defined, mechanisms which underlie these processes explored, and available treatment options discussed...
  65. ncbi Relative potency of incobotulinumtoxinA vs onabotulinumtoxinA a meta-analysis of key evidence
    Ravi Jandhyala
    Banbury Face Clinic, The Jandhyala Institute, Banbury, UK
    J Drugs Dermatol 11:731-6. 2012
    ..As such, clinicians should continue to consider the formulations to be equipotent until such time that compelling clinical evidence to the contrary becomes available...
  66. ncbi Genomic-driven insights into changes in aging skin
    Michael K Robinson
    Global Biotechnology, The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
    J Drugs Dermatol 8:s8-11. 2009
    ..Recent sequencing of the human genome and development of genome-wide microarray platforms now permit analysis of skin aging at the level of gene expression...
  67. ncbi Protective effects of topical antioxidants in humans
    F Dreher
    Department of Dermatology, University of California, San Francisco, Calif, USA
    Curr Probl Dermatol 29:157-64. 2001
    ..Furthermore, sunscreening agents may also benefit from combination with antioxidants resulting in increased safety and efficacy of such photoprotective products [11, 29]...
  68. ncbi Validated assessment scales for the upper face
    Timothy C Flynn
    Department of Dermatology, University of North Carolina at Chapel Hill, NC, USA
    Dermatol Surg 38:309-19. 2012
    ..The development of globally accepted tools to assess these changes objectively is an essential contribution to aesthetic research and routine clinical medicine...
  69. ncbi Botulinum toxin: clinical techniques, applications, and complications
    Scott Stephan
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Facial Plast Surg 27:529-39. 2011
    ..Detailed descriptions are provided for each clinical indication that maximize the treatment of the intended muscle groups while minimizing potential complications...
  70. ncbi Factors that affect skin aging: a cohort-based survey on twins
    Kathryn J Martires
    Department of Dermatology, University Hospitals, Case Medical Center, Case Western Reserve School of Medicine, Cleveland, OH, USA
    Arch Dermatol 145:1375-9. 2009
    ..To identify environmental factors that correlate with skin photoaging, controlling for genetic susceptibility by using a questionnaire administered to twins...
  71. ncbi Comparison of two botulinum toxin type A preparations for treating crow's feet: a split-face, double-blind, proof-of-concept study
    Welf Prager
    Dermatologikum Hamburg, Hamburg, Germany
    Dermatol Surg 36:2155-60. 2010
    ..This is the first double-blind, randomized, proof-of-concept study to compare the clinical effectiveness of botulinum toxin type A (BoNTA) free of complexing proteins with a BoNTA complex (BTXCo) in the treatment of crow's feet...
  72. ncbi Skin aging: postulated mechanisms and consequent changes in structure and function
    M Yaar
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Clin Geriatr Med 17:617-30, v. 2001
    ..New insights into age-associated decrements in DNA damage repair are reviewed. Age-associated gross, histologic, and functional cutaneous deficits are delineated. Different treatment options for aged skin are examined...
  73. ncbi Effects of intense pulsed light on sun-damaged human skin, routine, and ultrastructural analysis
    Victor G Prieto
    Department of Pathology, UT MD Anderson Cancer Center, Houston, Texas 77030, USA
    Lasers Surg Med 30:82-5. 2002
    ..New, non-ablative methods can be used in skin rejuvenation. Histologic analysis of non-ablative IPL effects on facial, sun-damaged skin...
  74. ncbi Molecular changes during skin aging and wound healing after fractional ablative photothermolysis
    Doris Helbig
    Department for Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany
    Skin Res Technol 17:119-28. 2011
    ..by major alterations of the extracellular matrix and collagen network, leading to clinically obvious signs of skin aging. UV radiation increases the levels of matrix metalloproteinase (MMP) 1, which initiates the cleavage of ..
  75. ncbi Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: individual antioxidant contribution of phenolics and transcriptional effect on skin aging
    Stéphanie Dudonné
    Biolandes Route de Bélis, Le Sen, France
    J Agric Food Chem 59:4527-36. 2011
    ..The transcriptional effect of poplar bud extract on skin aging was evaluated in vitro on a replicative senescence model of normal human dermal fibroblasts, using a customized ..
  76. ncbi Age and skin structure and function, a quantitative approach (II): protein, glycosaminoglycan, water, and lipid content and structure
    Jeanette M Waller
    University of California, Irvine, CA, USA
    Skin Res Technol 12:145-54. 2006
    ..These overviews piece together the immense amounts of information that have emerged from recent technological advances in dermatological research in order to develop a unified understanding of the quantitative effects of age on skin...
  77. ncbi Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury
    Dieter Manstein
    Wellman Laboratories of Photomedicine, Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Lasers Surg Med 34:426-38. 2004
    ..We introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin...
  78. pmc Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin
    Taihao Quan
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109 5609, USA
    J Invest Dermatol 130:415-24. 2010
    ..Downregulation of the TGF-beta/Smad/CTGF axis likely mediates reduced type I procollagen expression in aged human skin in vivo...
  79. ncbi Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice
    Paul R Hiebert
    Institute for Heart Lung Health, St Paul s Hospital, 166 1081 Burrard Street, Vancouver, British Columbia, Canada
    Exp Gerontol 46:489-99. 2011
    ..However, in addition to atherosclerosis, apoE-KO mice develop extensive cutaneous xanthomatosis, accelerated skin aging and frailty when fed a high fat diet...
  80. ncbi The spectrum of laser skin resurfacing: nonablative, fractional, and ablative laser resurfacing
    Macrene R Alexiades-Armenakas
    Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA
    J Am Acad Dermatol 58:719-37; quiz 738-40. 2008
    ....
  81. ncbi Photoaging as a consequence of natural and therapeutic ultraviolet irradiation--studies on PUVA-induced senescence-like growth arrest of human dermal fibroblasts
    Meinhard Wlaschek
    Department of Dermatology and Allergy, University of Ulm, Maienweg 12, Ulm 89081, Germany
    Exp Gerontol 38:1265-70. 2003
    ....
  82. ncbi Effect of smoking on skin elastic fibres: morphometric and immunohistochemical analysis
    M Just
    Department of Dermatology, Hospital Figueres, Figueres, Girona, Spain
    Br J Dermatol 156:85-91. 2007
    ..The underlying mechanism is not well known, but elastic fibres of the dermis seem to be the major target of smoke components...
  83. ncbi Tobacco smoke causes premature skin aging
    Akimichi Morita
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Dermatol Sci 48:169-75. 2007
    ..smoking is also associated with many dermatological conditions, including poor wound healing, premature skin aging, squamous cell carcinoma, melanoma, oral cancer, acne, psoriasis, and hair loss...
  84. ncbi Full scope of effect of facial lipoatrophy: a framework of disease understanding
    Benjamin Ascher
    Clinique IENA, Paris, France
    Dermatol Surg 32:1058-69. 2006
    ..There is currently no framework from which physicians of all medical specialties can communally discuss the manifestations, diagnoses, and management of facial lipoatrophy...
  85. ncbi Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice
    Hyeon Ho Kim
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, 28, Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Mech Ageing Dev 126:1170-7. 2005
    b>Skin aging can be divided into intrinsic aging and photoaging. Sunlight is a major cause of photoaging, and is composed of ultraviolet (UV) and infrared (IR) radiation...
  86. ncbi The wrinkle severity rating scale: a validation study
    Doris J Day
    Department of Dermatology, New York University Medical Center, New York, New York 10021, USA
    Am J Clin Dermatol 5:49-52. 2004
    ..Patient satisfaction is the most important outcome in facial aesthetic surgery. However, the need for evidence-based evaluation of aesthetic procedures dictates the use of more objective and quantitative measures of treatment outcome...
  87. ncbi Botulinum toxin: examining duration of effect in facial aesthetic applications
    Timothy Corcoran Flynn
    Cary Skin Center, Cary, North Carolina, USA
    Am J Clin Dermatol 11:183-99. 2010
    ..Additional research should help clarify the impact of age, baseline rhytid severity, patient sex, repeated treatments, and combination treatment on longevity of effect...
  88. pmc Smoking related COPD and facial wrinkling: is there a common susceptibility?
    B D Patel
    Department of Public Health and Primary Care, University of Cambridge, UK
    Thorax 61:568-571. 2006
    ..We have tested the hypothesis that there is a common susceptibility for the development of COPD and facial wrinkling in cigarette smokers...
  89. ncbi Intrinsic and extrinsic factors in skin ageing: a review
    M A Farage
    The Procter and Gamble Company, Winton Hill Business Center, Cincinnati, OH 45224, USA
    Int J Cosmet Sci 30:87-95. 2008
    ....
  90. ncbi Functional MC1R-gene variants are associated with increased risk for severe photoaging of facial skin
    Anissa Elfakir
    Biometrics and Epidemiology unit, CERIES, Neuilly sur Seine, France
    J Invest Dermatol 130:1107-15. 2010
    ..Surprisingly, the minor variant, V92M, was associated with increased risk of photoaging (2.57 (1.23-5.35)). Our results suggest that genetic variations of MC1R are important determinants for severe photoaging...
  91. ncbi Cellular and sub-cellular responses to UVA in relation to carcinogenesis
    Andrew J Ridley
    Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, UK
    Int J Radiat Biol 85:177-95. 2009
    UVA radiation (315-400 nm) contributes to skin aging and carcinogenesis...
  92. ncbi A validated grading scale for crow's feet
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S173-8. 2008
    ..To develop the Crow's Feet Grading Scale for objective quantification of the severity of lateral canthal lines and to establish the reliability of this photonumeric scale for clinical research and practice...
  93. ncbi Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin
    Annie E Chiu
    Department of Dermatology, Emory University, USA
    Dermatol Surg 31:855-60; discussion 860. 2005
    ..Green tea polyphenolic compounds have significant antioxidant and anti-inflammatory activities, and studies suggest that these extracts help mediate ultraviolet radiation damage...
  94. ncbi Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, USA
    Photochem Photobiol 69:154-7. 1999
    ..The tRA likely acts to reduce UV induction of c-Jun protein by stimulating its breakdown through the ubiquitin-proteasome pathway...
  95. ncbi Alteration of the TGF-beta/SMAD pathway in intrinsically and UV-induced skin aging
    Kwang Ho Han
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Mech Ageing Dev 126:560-7. 2005
    ..These results suggest that the UV-induced down-regulation of TbetaRII and the concerted over-expression of Smad7 may trigger the inhibition of the TGF-beta-induced phosphorylation of Smad2...
  96. ncbi Dermatoporosis. The functional side of skin aging
    Jean Hilaire Saurat
    Dermatology 215:271-2. 2007
  97. ncbi An anatomical evaluation and surgical approach to the perioral mound in facial rejuvenation
    Patrick K Sullivan
    Department of Plastic Surgery, Brown University Rhode Island Hospital, Providence, RI 02905 3240, USA
    Plast Reconstr Surg 126:1333-40. 2010
    ..Despite efforts to study and rejuvenate the aging periorbit, midface, and jowls, the effects of aging on the perioral mound have been less studied...
  98. ncbi Role of UV light in photodamage, skin aging, and skin cancer: importance of photoprotection
    Evelyn R Gonzaga
    Department of Medicine, Section of Dermatology, University of the Philippines, Philippine General Hospital, Manila, Philippines
    Am J Clin Dermatol 10:19-24. 2009
    ..Dosage guidelines recommend using more than half a teaspoon each on head and neck area and each arm, and more than a teaspoon each on anterior torso, posterior torso, and each leg (approximately 2 mg/cm(2))...
  99. ncbi The "R.A.R.E." technique (reverse and repositioning effect): the renaissance of the aging face and neck
    Thierry Besins
    Aesthetic Plast Surg 28:127-42. 2004
    ..Improvement in terms of facial rejuvenation is dramatic and the technique is quite safe and predictable. The only possible difficulty involves the patient's temporary initial concern about early postoperative appearance...
  100. pmc Effect of estrogens on skin aging and the potential role of SERMs
    Susan Stevenson
    Burns and Plastic Surgery Research Unit, School of Life Sciences, University of Bradford, Bradford, UK
    Clin Interv Aging 2:283-97. 2007
    ..Importantly, skin aging can be significantly delayed by the administration of estrogen...
  101. ncbi A novel promising therapy for skin aging: dermal multipotent stem cells against photoaged skin by activation of TGF-β/Smad and p38 MAPK signaling pathway
    Jianqiao Zhong
    Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China
    Med Hypotheses 76:343-6. 2011
    ..These would provide a novel approach for anti-skin photoaging...

Research Grants53

  1. Telomere-Mediated Protective Responses in Skin
    Barbara Gilchrest; Fiscal Year: 2007
    ..The studies will also explore the possible therapeutic potential of T-oligos that comparably induce these responses in the absence of actual DNA damage or telomere disruption. ..
  2. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..The outcomes from these studies will not only increase our knowledge of UV- induced multiple apoptotic signaling pathways, but will also lead us to the development of new therapeutics for treatment of UV-related skin aging and cancers.
  3. Role of exogenous melatonin in skin biology
    Andrzej T Slominski; Fiscal Year: 2013
    ..g. vitiligo or hyperpigmentation), proliferative processes (including precancerous states, epidermal cancer or even melanoma), UVB-induced pathology, inflammatory dermatoses and skin aging.
  4. 2013 Elastin, Elastic Fibers &Microfibrils Gordon Research Conference &Gordon R
    Zsolt Urban; Fiscal Year: 2013
    ..chronic obstructive pulmonary disease, vascular remodeling in systemic and pulmonary hypertension, and skin aging mechanisms...
  5. Role of Mitochondria in Estrogen Action and Cellular Senescence
    Michael C Velarde; Fiscal Year: 2013
    ..oxidative damage is thought to be one of the key mechanisms driving the aging process and can contribute to skin aging. Because estrogen can regulate mitochondrial function in several cell types, this study proposes that ..
  6. Mechanisms of Altered Skin Re-Epithelialization in Aging
    Laure Rittie; Fiscal Year: 2013
    ..I have been uniquely trained in clinical research in the field of skin aging and photoaging, and have a published record of productivity in this field...
  7. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary J Fisher; Fiscal Year: 2013
    ..The results from the proposed studies will provide important insights regarding 1) the age of onset of human skin aging, 2) molecular actions of topical antioxidant, 3) mechanisms by which oxidative exposure regulates the TGF-[..
  8. Aging and IGF-1 Receptor in a three dimensional matrix
    Itay Bentov; Fiscal Year: 2013
    ..Several lines of evidence suggest a functional relationship between expression and activation of the IGF1R and skin aging, which results in increased susceptibility to injury and reduced wound healing...
  9. eukaryotic expression vectors resistant to transgene silencing
    James Williams; Fiscal Year: 2012
    ..In Specific Aim 4 a dermatological gene therapy to treat skin aging is developed using a keratinocyte growth factor (KGF) vector- microdermabrasion delivery combination...
  10. Montagna Symposium on the Biology of Skin
    Molly F Kulesz-Martin; Fiscal Year: 2013
    ..Skin Cytoskeleton in Signaling and Function", "Light and Skin: Mechanisms, Applications and Diseases", and "Skin Aging", as well as developing topics in "Viral and other Infectious Diseases of the Skin" and "Skin Innervations and ..
  11. mTOR signaling in keratinocyte UVB response
    THERESA DIANE CARR; Fiscal Year: 2013
    ..Human skin is constantly exposed to UV light causing DNA damage that contributes to skin aging and the development of skin cancer...
  12. Interfollicular epidermal stem cells in human and mouse skin
    DENISE LEA GAY; Fiscal Year: 2011
    ..Ultimately, this research may impact on developing new treatments for skin problems such as chronic wounds, burns, alopecia and skin aging.
  13. REGULATION OF EPIDERMAL DIFFERENTATION BY PTHRP
    John Foley; Fiscal Year: 2004
    ..speculated to be a component of skin pathologies including wound healing disorders, some epidermal cancers, and skin aging. It appears there is an exchange of molecules between epidermis and dermis that is crucial to the function of ..
  14. MODULATION OF LANGERHANS CELL FUNCTION BY UVB RADIATION
    Paul Bergstresser; Fiscal Year: 2004
    Exposure of skin to ultraviolet (UV) radiation (UVR) causes sunburn, tanning, carcinogenesis, skin aging, and impaired immunity...
  15. CYTOKINE EXPRESSION AND SIGNALLING IN AGED EPIDERMIS
    Ruby Ghadially; Fiscal Year: 2000
    ..project is a logical next step to her prior work in epidermal aging and complements her sponsor's project on skin aging. As during her Dermatology Foundation Clinical Investigatorship, Dr...
  16. IN VITRO MODEL FOR MEASURING SUNSCREEN PROTECTION
    Patrick Hayden; Fiscal Year: 2001
    ..Excessive exposure to solar radiation results in erythema (sunburn) and has been linked to premature skin aging, immunosuppression and skin cancer...
  17. Double-Gated Selection of Ligands that Target Surface Markers of Differentiation
    David Larocca; Fiscal Year: 2009
    ..degenerative diseases such as heart disease, Alzheimer's disease, Parkinson's, multiple sclerosis, skin aging and macular degeneration, to name a few...
  18. TOPS-Ester Modulation of UVB-Induced Immune Suppression
    CARLETON HSIA; Fiscal Year: 2002
    ..cells and express antioxidant activity that limits oxidant mediated pathologies including psoriasis, sunburn, skin aging and skin cancer...
  19. TOPS-Ester: Pharmacokinetics and Imaging in Human Skin
    CARLETON HSIA; Fiscal Year: 2003
    ..cells and express antioxidant activity that limits oxidant mediated pathologies including psoriasis, sunburn, skin aging and skin cancer...
  20. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..
  21. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  22. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  23. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ....
  24. Social Pyschological Interventions for UV Protection
    HEIKE MAHLER; Fiscal Year: 2006
    ..Thus, the studies should provide useful information about process as well as outcome. ..
  25. MELANOMA CONTROL FOR SIBLING OF MELANOMA PATIENTS
    Barbara Gilchrest; Fiscal Year: 2001
    ....
  26. Telomere homolog oligonucleotides for cancer therapy
    Barbara Gilchrest; Fiscal Year: 2004
    ..abstract_text> ..
  27. Prevention of Skin Cancer by Scutellaria Baicalensis
    Huachen Wei; Fiscal Year: 2004
    ..abstract_text> ..
  28. Irradiation Damage and Protection of Pulmonary Endothelium Oxidative Lipidomics
    Valerian E Kagan; Fiscal Year: 2010
    ....
  29. Ultraviolet B irradiation of human keratinocytes
    Dan Spandau; Fiscal Year: 2004
    ..Through the identification of these components of the UVB-response in human keratinocytes, therapeutic strategies for the prevention of LTVB-induced carcinogenesis can be developed. ..
  30. CYCLIC ADP RIBOSE METABOLISM IN OXIDATIVE CELL DEATH
    MYRON JACOBSON; Fiscal Year: 2002
    ....
  31. Carbonyl scavengers for skin protection from glycation
    ELAINE JACOBSON; Fiscal Year: 2003
    ....
  32. Conference--Dermatologic Disease in Skin of Color
    Susan Taylor; Fiscal Year: 2002
    ..They believe that these presentations and discussions will lead to a greater interest in the specific problem related to access to care for dermatologic disease among persons of color. ..
  33. SYNERGISTIC CARCINOGENICTY OF UVA AND BENZO(A)PYRENE
    Huachen Wei; Fiscal Year: 2003
    ..abstract_text> ..
  34. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
  35. COPPER/ALBUMIN REDOX-CYCLING IN PREECLAMPSIA
    Valerian Kagan; Fiscal Year: 2003
    ....
  36. CYR61-a novel potential mediator of photoaged human skin
    Taihao Quan; Fiscal Year: 2010
    ..applicant): Ultraviolet (UV) irradiation from the sun damages human skin connective tissue and causes premature skin aging (photoaging)...
  37. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  38. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2009
    ..This study will validate endogenous structural skin components as novel molecular Itargets for chemoprevention in skin photocarcinogenesis and photoaging and lead to a new class of Iphotoprotective agents. ..
  39. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  40. GENISTEIN IN INVESTIGATIVE AND CLINICAL DERMATOLOGY
    Huachen Wei; Fiscal Year: 2005
    ..Successful completion of the proposed studies will contribute to development of this soybean isoflavone as a preventive and/or therapeutic agent against human skin cancer and photodamage. ..
  41. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2005
    ..Increased understanding of the role played by enzymatic mechanisms that determine levels of dicarbonyls and Amadori products and their resulting AGEs is essential if we are to find effective strategies to prevent diabetic nephropathy. ..
  42. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ....
  43. DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORS
    David Archer; Fiscal Year: 2006
    ..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
  44. Glycation and mu dicarbonyls in diabetic complications
    Paul Beisswenger; Fiscal Year: 2006
    ..These exciting research projects, and new ones on the horizon, combined with the proposed mentoring/training program offers real opportunities of attracting and rewarding a new generation of clinical investigators. ..
  45. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  46. ALTERATION OF NAD METABOLISM BY CHEMICAL CARCINOGENS
    MYRON JACOBSON; Fiscal Year: 2008
    ..The proposed research also provides the opportunity to evaluate PARG as a therapeutic target. ..
  47. Quantification of the environmental UVA exposure
    Michael Kimlin; Fiscal Year: 2008
    ..abstract_text> ..
  48. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  49. CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGY
    Sewon Kang; Fiscal Year: 2004
    ..abstract_text> ..
  50. Physiological Responses to Pictures and Exercise in Dysphoria
    Jerome Smith; Fiscal Year: 2004
    ..The largest effect for restoring pleasant emotional responsiveness is expected to occur in the least aerobically fit dysphoric individuals. ..