germination

Summary

Summary: The initial stages of the growth of SEEDS into a SEEDLING. The embryonic shoot (plumule) and embryonic PLANT ROOTS (radicle) emerge and grow upwards and downwards respectively. Food reserves for germination come from endosperm tissue within the seed and/or from the seed leaves (COTYLEDON). (Concise Dictionary of Biology, 1990)

Top Publications

  1. ncbi Regulators of PP2C phosphatase activity function as abscisic acid sensors
    Yue Ma
    Lehrstuhl fur Botanik, Technische Universitat Munchen, Am Hochanger 4, D 85354 Freising, Germany
    Science 324:1064-8. 2009
  2. pmc Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins
    Sang Youl Park
    Department of Botany and Plant Sciences, University of California at Riverside, Riverside, CA 92521, USA
    Science 324:1068-71. 2009
  3. pmc Abscisic acid signaling in seeds and seedlings
    Ruth R Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
    Plant Cell 14:S15-45. 2002
  4. ncbi ABA induction of miR159 controls transcript levels of two MYB factors during Arabidopsis seed germination
    Jose L Reyes
    Laboratory of Plant Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Plant J 49:592-606. 2007
  5. ncbi Seed dormancy and the control of germination
    William E Finch-Savage
    Warwick HRI, Warwick University, Wellesbourne, Warwick CV35 9EF, UK
    New Phytol 171:501-23. 2006
  6. pmc Arabidopsis cytokinin receptor mutants reveal functions in shoot growth, leaf senescence, seed size, germination, root development, and cytokinin metabolism
    Michael Riefler
    Institute of Biology Applied Genetics, Free University of Berlin, Germany
    Plant Cell 18:40-54. 2006
  7. ncbi Molecular networks regulating Arabidopsis seed maturation, after-ripening, dormancy and germination
    Michael J Holdsworth
    Department of Agricultural and Environmental Sciences, School of Biosciences, University of Nottingham, Nottingham LE12 5RD, UK
    New Phytol 179:33-54. 2008
  8. ncbi Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy
    Kazuo Nakashima
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, Ibaraki, Japan
    Plant Cell Physiol 50:1345-63. 2009
  9. ncbi ABI5 acts downstream of ABI3 to execute an ABA-dependent growth arrest during germination
    Luis Lopez-Molina
    Laboratory of Plant Molecular Biology, Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Plant J 32:317-28. 2002
  10. ncbi Molecular aspects of seed dormancy
    Ruth Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Annu Rev Plant Biol 59:387-415. 2008

Detail Information

Publications388 found, 100 shown here

  1. ncbi Regulators of PP2C phosphatase activity function as abscisic acid sensors
    Yue Ma
    Lehrstuhl fur Botanik, Technische Universitat Munchen, Am Hochanger 4, D 85354 Freising, Germany
    Science 324:1064-8. 2009
    ..Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes...
  2. pmc Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins
    Sang Youl Park
    Department of Botany and Plant Sciences, University of California at Riverside, Riverside, CA 92521, USA
    Science 324:1068-71. 2009
    ..Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy...
  3. pmc Abscisic acid signaling in seeds and seedlings
    Ruth R Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
    Plant Cell 14:S15-45. 2002
  4. ncbi ABA induction of miR159 controls transcript levels of two MYB factors during Arabidopsis seed germination
    Jose L Reyes
    Laboratory of Plant Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Plant J 49:592-606. 2007
    ..Our results suggest that ABA-induced accumulation of miR159 is a homeostatic mechanism to direct MYB33 and MYB101 transcript degradation to desensitize hormone signaling during seedling stress responses...
  5. ncbi Seed dormancy and the control of germination
    William E Finch-Savage
    Warwick HRI, Warwick University, Wellesbourne, Warwick CV35 9EF, UK
    New Phytol 171:501-23. 2006
    ..Through this adaptation, germination is timed to avoid unfavourable weather for subsequent plant establishment and reproductive growth...
  6. pmc Arabidopsis cytokinin receptor mutants reveal functions in shoot growth, leaf senescence, seed size, germination, root development, and cytokinin metabolism
    Michael Riefler
    Institute of Biology Applied Genetics, Free University of Berlin, Germany
    Plant Cell 18:40-54. 2006
    ..Mutant seeds had more rapid germination, reduced requirement for light, and decreased far-red light sensitivity, unraveling cytokinin functions in seed ..
  7. ncbi Molecular networks regulating Arabidopsis seed maturation, after-ripening, dormancy and germination
    Michael J Holdsworth
    Department of Agricultural and Environmental Sciences, School of Biosciences, University of Nottingham, Nottingham LE12 5RD, UK
    New Phytol 179:33-54. 2008
    The transition between dormancy and germination represents a critical stage in the life cycle of higher plants and is an important ecological and commercial trait...
  8. ncbi Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy
    Kazuo Nakashima
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, Ibaraki, Japan
    Plant Cell Physiol 50:1345-63. 2009
    ..an important phytohormone regulating various plant processes, including stress tolerance, seed development and germination. SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2...
  9. ncbi ABI5 acts downstream of ABI3 to execute an ABA-dependent growth arrest during germination
    Luis Lopez-Molina
    Laboratory of Plant Molecular Biology, Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Plant J 32:317-28. 2002
    ..Although ABI5 is consistently located in the nucleus, chromosomal immunoprecipitation (ChIP) experiments revealed that ABA increases ABI5 occupancy on the AtEm6 promoter...
  10. ncbi Molecular aspects of seed dormancy
    Ruth Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Annu Rev Plant Biol 59:387-415. 2008
    Seed dormancy provides a mechanism for plants to delay germination until conditions are optimal for survival of the next generation...
  11. pmc Mapping salinity tolerance during Arabidopsis thaliana germination and seedling growth
    Leah DeRose-Wilson
    Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e22832. 2011
    ..and dissect genetic variation for salinity tolerance, we assessed variation in salinity tolerance during germination and seedling growth for a worldwide sample of Arabidopsis thaliana accessions...
  12. pmc Identification and characterization of maize microRNAs involved in the very early stage of seed germination
    Liwen Wang
    State Key Laboratory of Crop Biology, Shandong Agricultural University, Taian, Shandong 271018, PR China
    BMC Genomics 12:154. 2011
    ..However, the number of miRNAs discovered in maize is relatively low and little is known about miRNAs involved in the very early stage during seed germination.
  13. pmc MOTHER OF FT AND TFL1 regulates seed germination through a negative feedback loop modulating ABA signaling in Arabidopsis
    Wanyan Xi
    Department of Biological Sciences and Temasek Life Sciences Laboratory, National University of Singapore, 117543, Singapore
    Plant Cell 22:1733-48. 2010
    Abscisic acid (ABA) and gibberellin (GA) are two antagonistic phytohormones that regulate seed germination in response to biotic and abiotic environmental stresses...
  14. pmc CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis
    Masanori Okamoto
    RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    Plant Physiol 141:97-107. 2006
    ..On the other hand, CYP707A2 is responsible for the regulation of ABA levels from late-maturation to germination. Moreover, CYP707A1 and CYP707A3 were also shown to be involved in postgermination growth...
  15. pmc The Mg-chelatase H subunit of Arabidopsis antagonizes a group of WRKY transcription repressors to relieve ABA-responsive genes of inhibition
    Yi Shang
    Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Plant Cell 22:1909-35. 2010
    ..factors (WRKY40, WRKY18, and WRKY60) that function as negative regulators of ABA signaling in seed germination and postgermination growth...
  16. pmc Arabidopsis mutant deficient in 3 abscisic acid-activated protein kinases reveals critical roles in growth, reproduction, and stress
    Hiroaki Fujii
    Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 106:8380-5. 2009
    Abscisic acid (ABA) is an important phytohormone regulating seed dormancy, germination, seedling growth, and plant transpiration...
  17. pmc Genome-wide network model capturing seed germination reveals coordinated regulation of plant cellular phase transitions
    George W Bassel
    Division of Plant and Crop Sciences, School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham, Loughborough LE12 5RD, United Kingdom
    Proc Natl Acad Sci U S A 108:9709-14. 2011
    Seed germination is a complex trait of key ecological and agronomic significance...
  18. ncbi The Arabidopsis Ca(2+) -dependent protein kinase CPK12 negatively regulates abscisic acid signaling in seed germination and post-germination growth
    Rui Zhao
    College of Biological Sciences, China Agricultural University, 100094 Beijing, China
    New Phytol 192:61-73. 2011
    ..CPK12-RNAi lines, and observed that downregulation of CPK12 resulted in ABA hypersensitivity in seed germination and post-germination growth, and altered expression of a set of ABA-responsive genes...
  19. pmc Ethylene interacts with abscisic acid to regulate endosperm rupture during germination: a comparative approach using Lepidium sativum and Arabidopsis thaliana
    Ada Linkies
    University of Freiburg, Faculty of Biology, Institute for Biology II, Botany Plant Physiology, D 79104 Freiburg, Germany
    Plant Cell 21:3803-22. 2009
    ..cap covering the radicle in the mature seeds of most angiosperms acts as a constraint that regulates seed germination. Here, we report on a comparative seed biology study with the close Brassicaceae relatives Lepidium sativum and ..
  20. pmc A postgermination developmental arrest checkpoint is mediated by abscisic acid and requires the ABI5 transcription factor in Arabidopsis
    L Lopez-Molina
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 98:4782-7. 2001
    ..is a trait of considerable adaptive significance because it maximizes seedling survival by preventing premature germination under unfavorable conditions...
  21. pmc Arabidopsis ABA INSENSITIVE4 regulates lipid mobilization in the embryo and reveals repression of seed germination by the endosperm
    Steven Penfield
    Department of Biology, Centre for Novel Agricultural Products, University of York, York YO10 5YW, United Kingdom
    Plant Cell 18:1887-99. 2006
    Regulation of seed germination requires coordinate action by the embryo and surrounding endosperm...
  22. pmc Strigolactones are transported through the xylem and play a key role in shoot architectural response to phosphate deficiency in nonarbuscular mycorrhizal host Arabidopsis
    Wouter Kohlen
    Laboratory of Plant Physiology, Wageningen University, 6708 PB Wageningen, The Netherlands
    Plant Physiol 155:974-87. 2011
    ..Together, these results show that xylem-transported strigolactones contribute to the regulation of shoot architectural response to phosphate-limiting conditions...
  23. pmc The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis
    Girdhar K Pandey
    Department of Plant and Microbial Biology, University of California, Berkeley 94720, USA
    Plant Cell 16:1912-24. 2004
    ..The mutant plants became hypersensitive to ABA in the early developmental stages, including seed germination and post-germination seedling growth...
  24. pmc The time required for dormancy release in Arabidopsis is determined by DELAY OF GERMINATION1 protein levels in freshly harvested seeds
    Kazumi Nakabayashi
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany
    Plant Cell 24:2826-38. 2012
    Seed dormancy controls the start of a plant's life cycle by preventing germination of a viable seed in an unfavorable season...
  25. ncbi Defective chloroplast development inhibits maintenance of normal levels of abscisic acid in a mutant of the Arabidopsis RH3 DEAD-box protein during early post-germination growth
    Kwang Hee Lee
    Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA
    Plant J 73:720-32. 2013
    ....
  26. ncbi Seed germination and vigor
    Loïc Rajjou
    CNRS Bayer CropScience Joint Laboratory, UMR 5240, Bayer CropScience, Lyon cedex 9, France
    Annu Rev Plant Biol 63:507-33. 2012
    b>Germination vigor is driven by the ability of the plant embryo, embedded within the seed, to resume its metabolic activity in a coordinated and sequential manner...
  27. ncbi Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages
    Po Pu Liu
    Department of Horticulture, Oregon State University, Corvallis, OR 97331, USA
    Plant J 52:133-46. 2007
    ..Here, we show that negative regulation of ARF10 by miR160 plays important roles in seed germination and post-germination...
  28. ncbi A rice orthologue of the ABA receptor, OsPYL/RCAR5, is a positive regulator of the ABA signal transduction pathway in seed germination and early seedling growth
    Hyunmi Kim
    Department of Bio crop development, National Academy of Agricultural Science, Rural Development Administration, Suwon, 441 707, Korea
    J Exp Bot 63:1013-24. 2012
    ..expressing OsPYL/RCAR5, a PYL/RCAR orthologue of rice, were found to be hypersensitive to ABA during seed germination and early seedling growth...
  29. pmc Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis
    Yi Wang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, National Plant Gene Research Center, China Agricultural University, Beijing 100193, China
    Plant Physiol 148:1201-11. 2008
    Pollen germination, along with pollen tube growth, is an essential process for the reproduction of flowering plants...
  30. ncbi Expression of genes involved in germination, conidiogenesis and pathogenesis in Metarhizium anisopliae using quantitative real-time RT-PCR
    Weiguo Fang
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
    Mycol Res 110:1165-71. 2006
    Characterization of genes involved in germination, conidiogenesis and insect pathogenesis is an important step in identifying methods to increase the efficacy of Metarhizium anisopliae, a commercially important entomopathogenic fungus...
  31. pmc The gibberellic acid signaling repressor RGL2 inhibits Arabidopsis seed germination by stimulating abscisic acid synthesis and ABI5 activity
    Urszula Piskurewicz
    Universite de Geneve, Département de Biologie Végétale, 1211 Geneva 4, Switzerland
    Plant Cell 20:2729-45. 2008
    Seed germination is antagonistically controlled by the phytohormones gibberellic acid (GA) and abscisic acid (ABA)...
  32. pmc Della proteins and gibberellin-regulated seed germination and floral development in Arabidopsis
    Ludmila Tyler
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Plant Physiol 135:1008-19. 2004
    ..However, rga and gai in combination cannot rescue seed germination or floral development in ga1-3...
  33. pmc Gibberellin regulates Arabidopsis seed germination via RGL2, a GAI/RGA-like gene whose expression is up-regulated following imbibition
    Sorcheng Lee
    Institute of Molecular Agrobiology, National University of Singapore, Singapore 117604
    Genes Dev 16:646-58. 2002
    The germination of Arabidopsis seeds is promoted by gibberellin (GA). Arabidopsis GAI, and RGA are genes encoding key GA signal-transduction components (GAI and RGA) that mediate GA regulation of stem elongation...
  34. pmc Genome-wide analysis of genes targeted by PHYTOCHROME INTERACTING FACTOR 3-LIKE5 during seed germination in Arabidopsis
    Eunkyoo Oh
    Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
    Plant Cell 21:403-19. 2009
    ..PHYTOCHROME INTERACTING FACTOR 3-LIKE5 (PIL5) is a basic helix-loop-helix transcription factor that inhibits seed germination by regulating the expression of gibberellin (GA)- and abscisic acid (ABA)-related genes either directly or ..
  35. ncbi AtMKK1 and AtMPK6 are involved in abscisic acid and sugar signaling in Arabidopsis seed germination
    Yu Xing
    Department of Biology, Hong Kong Baptist University, Hong Kong, China
    Plant Mol Biol 70:725-36. 2009
    Abscisic acid (ABA) and sugars have been well established to be crucial factors controlling seed germination of Arabidopsis...
  36. ncbi Genome-wide profiling of stored mRNA in Arabidopsis thaliana seed germination: epigenetic and genetic regulation of transcription in seed
    Kazumi Nakabayashi
    Plant Science Center, RIKEN, Suehiro cho 1 7 22, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Plant J 41:697-709. 2005
    ..Our analyses reveal that transcriptomes of Arabidopsis seed are characterized by multiple regulatory mechanisms: epigenetic chromatin structures, chromosomal locations (e.g. co-regulated gene clusters) and cis-acting elements...
  37. ncbi Niche construction through germination cueing: life-history responses to timing of germination in Arabidopsis thaliana
    Kathleen Donohue
    Department of Organismic and Evolutionary Biology, Harvard University, 22 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Evolution 59:771-85. 2005
    b>Germination responses to seasonal conditions determine the environment experienced by postgermination life stages, and this ability has potential consequences for the evolution of plant life histories...
  38. pmc Mitogen-activated protein kinase signaling in postgermination arrest of development by abscisic acid
    C Lu
    Delaware Biotechnology Institute, 15 Innovation Way, Newark 19711, USA
    Proc Natl Acad Sci U S A 99:15812-7. 2002
    Abscisic acid (ABA) mediates plant responses to environmental stress, particularly to water status. During germination, the embryo emerges from dormancy as the ABA concentration declines...
  39. ncbi First off the mark: early seed germination
    Karin Weitbrecht
    Botany Plant Physiology, Institute for Biology II, Faculty of Biology, University of Freiburg, Schänzlestr 1, D 79104 Freiburg, Germany
    J Exp Bot 62:3289-309. 2011
    ..are non-dormant and the environmental conditions are favourable, they will pass through the complex process of germination. In this review, recent progress made with state-of-the-art techniques including genome-wide gene expression ..
  40. ncbi Temporal expression patterns of hormone metabolism genes during imbibition of Arabidopsis thaliana seeds: a comparative study on dormant and non-dormant accessions
    Jeremy Preston
    Growth Regulation Research Group, RIKEN Plant Science Center, 1 7 22, Suehiro cho, Tsurumi, Yokohama, 230 0045, Japan
    Plant Cell Physiol 50:1786-800. 2009
    Seed imbibition is a prerequisite for subsequent dormancy and germination control...
  41. ncbi Glucose-induced delay of seed germination in rice is mediated by the suppression of ABA catabolism rather than an enhancement of ABA biosynthesis
    Guohui Zhu
    College of Life Science, South China Agricultural University, Guangdong, PR China
    Plant Cell Physiol 50:644-51. 2009
    Both glucose and ABA play crucial roles in the regulation of seed germination and post-germination development...
  42. ncbi Phosphorus deficiency in red clover promotes exudation of orobanchol, the signal for mycorrhizal symbionts and germination stimulant for root parasites
    Kaori Yoneyama
    United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu 183 8509, Japan
    Planta 225:1031-8. 2007
    Plant derived sesquiterpene strigolactones, which have previously been characterized as germination stimulants for root parasitic plants, have recently been identified as the branching factors which induce hyphal branching morphogenesis, ..
  43. pmc In-depth temporal transcriptome profiling reveals a crucial developmental switch with roles for RNA processing and organelle metabolism that are essential for germination in Arabidopsis
    Reena Narsai
    Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia
    Plant Physiol 157:1342-62. 2011
    b>Germination represents a rapid transition from dormancy to a high level of metabolic activity...
  44. ncbi Proteomic analysis of rice (Oryza sativa) seeds during germination
    Pingfang Yang
    Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, PR China
    Proteomics 7:3358-68. 2007
    Although seed germination is a major subject in plant physiological research, there is still a long way to go to elucidate the mechanism of seed germination...
  45. ncbi Temperature as a determinant factor for increased and reproducible in vitro pollen germination in Arabidopsis thaliana
    Leonor C Boavida
    Plant Gene Expression Center and Plant and Microbial Biology, USDA ARS and UC Berkeley, 800 Buchanan Street, Albany, CA 94710, USA
    Plant J 52:570-82. 2007
    Despite much effort, a robust protocol for in vitro germination of Arabidopsis thaliana pollen has been elusive...
  46. ncbi Tomato strigolactones are derived from carotenoids and their biosynthesis is promoted by phosphate starvation
    Juan Antonio Lopez-Raez
    Plant Research International, P O Box 16, NL 6700 AA Wageningen, The Netherlands
    New Phytol 178:863-74. 2008
    ..biosynthesis inhibitor fluridone and in the abscisic acid (ABA) mutant notabilis were assessed using a germination bioassay with seeds of Orobanche ramosa; a hyphal branching assay with Gigaspora spp; and by liquid ..
  47. ncbi Hydrogen sulfide promotes wheat seed germination and alleviates oxidative damage against copper stress
    Hua Zhang
    School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China
    J Integr Plant Biol 50:1518-29. 2008
    With the enhancement of copper (Cu) stress, the germination percentage of wheat seeds decreased gradually...
  48. pmc Strigolactones stimulate arbuscular mycorrhizal fungi by activating mitochondria
    Arnaud Besserer
    UMR 5546, Pôle de Biotechnologies Végétales, Castanet Tolosan, France
    PLoS Biol 4:e226. 2006
    ..have shown that roots secrete a branching factor (BF) that strongly stimulates branching of hyphae during germination of the spores of AM fungi. In the BF of Lotus, a strigolactone was found to be the active molecule...
  49. pmc G-protein complex mutants are hypersensitive to abscisic acid regulation of germination and postgermination development
    Sona Pandey
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802 5301, USA
    Plant Physiol 141:243-56. 2006
    ..Seed germination, early seedling development, stomatal guard cell functions, and acclimation to adverse environmental conditions ..
  50. pmc Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis
    Leonie Bentsink
    Laboratory of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 103:17042-7. 2006
    ..In this study we describe the identification of the DELAY OF GERMINATION 1 (DOG1) gene previously identified as a quantitative trait locus involved in the control of seed dormancy...
  51. pmc Plant lipoxygenases. Physiological and molecular features
    Helena Porta
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apartado Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Plant Physiol 130:15-21. 2002
  52. pmc The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination
    Motoki Tanaka
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan
    Plant Physiol 146:149-61. 2008
    ..Although the repression of embryogenesis-related genes during germination has been proposed to occur, the role of HDAC in this process has not been elucidated...
  53. ncbi A membrane-bound NAC transcription factor NTL8 regulates gibberellic acid-mediated salt signaling in Arabidopsis seed germination
    Sang Gyu Kim
    Department of Chemistry, Molecular Signaling Laboratory, Seoul National University, Seoul 151 742, Korea
    Plant J 55:77-88. 2008
    Gibberellic acid (GA) plays a key role in seed germination through coordinate interactions with other growth hormones and external signals...
  54. pmc ABR1, an APETALA2-domain transcription factor that functions as a repressor of ABA response in Arabidopsis
    Girdhar K Pandey
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant Physiol 139:1185-93. 2005
    ..identified an APETALA2 (AP2) domain transcription factor that serves as a repressor of ABA response during seed germination and ABA- and stress-induced gene expression in Arabidopsis (Arabidopsis thaliana)...
  55. ncbi Post-genomics dissection of seed dormancy and germination
    Michael J Holdsworth
    Department of Agricultural and Environmental Sciences, University of Nottingham, Nottingham LE12 5RD, UK
    Trends Plant Sci 13:7-13. 2008
    Studies of genome expression in Arabidopsis have provided important new information about mechanisms controlling germination and suggest new avenues to explore...
  56. pmc Major flowering time gene, flowering locus C, regulates seed germination in Arabidopsis thaliana
    George C K Chiang
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:11661-6. 2009
    ..Here, we document that FLC also regulates another major life-history transition-seed germination, and that natural variation at the FLC locus and in FLC expression is associated with natural variation in ..
  57. pmc Nucleotide and RNA metabolism prime translational initiation in the earliest events of mitochondrial biogenesis during Arabidopsis germination
    Simon R Law
    Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley 6009, Western Australia, Australia
    Plant Physiol 158:1610-27. 2012
    Mitochondria play a crucial role in germination and early seedling growth in Arabidopsis (Arabidopsis thaliana)...
  58. ncbi Diversification of phytochrome contributions to germination as a function of seed-maturation environment
    Kathleen Donohue
    Department of Organismic and Evolutionary Biology, Harvard University, 22 Divinity Ave, Cambridge, MA 02138, USA
    New Phytol 177:367-79. 2008
    Environmental conditions during seed maturation influence germination, but the genetic basis of maternal environmental effects on germination is virtually unknown...
  59. pmc The GCR2 gene family is not required for ABA control of seed germination and early seedling development in Arabidopsis
    Jianjun Guo
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 3:e2982. 2008
    ..It has been hypothesized that gcr2 appears only weakly insensitive to ABA because two other GCR2-like genes in Arabidopsis, GCL1 and GCL2, compensate for the loss of function of GCR2...
  60. pmc SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds
    Peter J Eastmond
    Department of Biology, Centre for Novel Agricultural Products, University of York, York YO10 5YW, United Kingdom
    Plant Cell 18:665-75. 2006
    ..These data shed light on the mechanism of lipolysis in plants and establish that a central component is evolutionarily conserved among eukaryotes...
  61. ncbi The wheat chloroplastic small heat shock protein (sHSP26) is involved in seed maturation and germination and imparts tolerance to heat stress
    Harsh Chauhan
    Department of Plant Molecular Biology, University of Delhi, South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi 110 021, India
    Plant Cell Environ 35:1912-31. 2012
    ..Transgenic plants produced bold seeds under high temperature, having higher germination potential than the wild-type plants...
  62. pmc Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron
    Viviane Lanquar
    Institut des Sciences du Vegetal, CNRS, Gif sur Yvette, France
    EMBO J 24:4041-51. 2005
    ..Indeed, the germination of nramp3 nramp4 double mutants is arrested under low Fe nutrition and fully rescued by high Fe supply...
  63. pmc Arabidopsis fatty acid desaturase FAD2 is required for salt tolerance during seed germination and early seedling growth
    Jiantao Zhang
    National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e30355. 2012
    ..fad2 accumulated more Na+ in the cytoplasm of root cells, and was more sensitive to salt stress during seed germination and early seedling growth, as indicated by CoroNa-Green staining, net Na+ efflux and salt tolerance analyses...
  64. pmc Role of a heterotrimeric G protein in regulation of Arabidopsis seed germination
    Hemayet Ullah
    Department of Agronomy, Nanjing Agricultural University, Nanjing 210095, People s Republic of China
    Plant Physiol 129:897-907. 2002
    Seed germination is regulated by many signals. We investigated the possible involvement of a heterotrimeric G protein complex in this signal regulation...
  65. pmc The GCR1, GPA1, PRN1, NF-Y signal chain mediates both blue light and abscisic acid responses in Arabidopsis
    Katherine M Warpeha
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois, Chicago, Illinois 60607, USA
    Plant Physiol 143:1590-600. 2007
    ..We also demonstrate that this mechanism is present in imbibed seeds wherein it affects germination rate.
  66. ncbi Environmental and genetic sources of diversification in the timing of seed germination: implications for the evolution of bet hedging
    Andrew M Simons
    Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario KIS 5B6, Canada
    Evolution 60:2280-92. 2006
    ..The high variance observed in the timing of seed germination has led to it being the most cited diversification strategy in the theoretical bet-hedging literature...
  67. pmc A wheat homolog of MOTHER OF FT AND TFL1 acts in the regulation of germination
    Shingo Nakamura
    National Institute of Crop Science, Tsukuba 305 8518, Japan
    Plant Cell 23:3215-29. 2011
    ..In a complementation analysis, high levels of MFT expression were correlated with a low germination index in T1 seeds...
  68. pmc Seed storage oil mobilization is important but not essential for germination or seedling establishment in Arabidopsis
    Amelie A Kelly
    School of Life Sciences, University of Warwick, Wellesbourne, Warwickshire CV359EF, United Kingdom
    Plant Physiol 157:866-75. 2011
    ..sugar-dependent1 (sdp1) that is impaired in TAG hydrolysis following Arabidopsis (Arabidopsis thaliana) seed germination (Eastmond, 2006)...
  69. ncbi ABA and sugar interactions regulating development: cross-talk or voices in a crowd?
    Ruth R Finkelstein
    Department of Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California 93106, USA
    Curr Opin Plant Biol 5:26-32. 2002
    ..acid and sugars have both similar and antagonistic effects on diverse processes, including seed development, germination, and seedling growth...
  70. pmc Roles of arabidopsis WRKY18, WRKY40 and WRKY60 transcription factors in plant responses to abscisic acid and abiotic stress
    Han Chen
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China
    BMC Plant Biol 10:281. 2010
    ..Arabidopsis WRKY18, WRKY40, and WRKY60 transcription factors interact both physically and functionally in plant defense responses. However, their role in plant abiotic stress response has not been directly analyzed...
  71. ncbi Seed dormancy and germination
    Maarten Koornneef
    Laboratory of Genetics, Department of Plant Sciences, Wageningen University, Arboretumlaan 4, 6703 BD, Wageningen, The Netherlands
    Curr Opin Plant Biol 5:33-6. 2002
    Seed dormancy and germination are complex adaptive traits of higher plants that are influenced by a large number of genes and environmental factors...
  72. pmc Endoplasmic reticulum- and Golgi-localized phospholipase A2 plays critical roles in Arabidopsis pollen development and germination
    Hae Jin Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Plant Cell 23:94-110. 2011
    ..2) localize to the endoplasmic reticulum and/or Golgi, and (3) play critical roles in pollen development and germination and tube growth. The suppression of PLA(2) using the RNA interference approach resulted in pollen lethality...
  73. ncbi Reactive oxygen species produced by NADPH oxidase are involved in pollen tube growth
    Martin Potocky
    Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Rozvojova 263, 16502 Prague 6, Czech Republic
    New Phytol 174:742-51. 2007
    ..The results show that tip-localized ROS produced by a NOX enzyme is needed to sustain the normal rate of pollen tube growth and that this is likely to be a general mechanism in the control of tip growth of polarized plant cells...
  74. pmc CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis
    Kyung Nam Kim
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 15:411-23. 2003
    ..protein kinase that associates with a calcineurin B-like calcium sensor, regulates ABA response during seed germination and ABA- and stress-induced gene expression in Arabidopsis...
  75. pmc CHOTTO1, a putative double APETALA2 repeat transcription factor, is involved in abscisic acid-mediated repression of gibberellin biosynthesis during seed germination in Arabidopsis
    Ryoichi Yano
    RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    Plant Physiol 151:641-54. 2009
    ..abscisic acid (ABA) and gibberellins (GAs) are the primary signals that regulate seed dormancy and germination. In this study, we investigated the role of a double APETALA2 repeat transcription factor, CHOTTO1 (CHO1), in ..
  76. ncbi Beyond gibberellins and abscisic acid: how ethylene and jasmonates control seed germination
    Ada Linkies
    Botany Plant Physiology, Institute for Biology II, Faculty of Biology, University of Freiburg, Schänzlestr 1, 79104, Freiburg, Germany
    Plant Cell Rep 31:253-70. 2012
    ..Adaptation of germination to abiotic stresses and changing environmental conditions is decisive for fitness and survival of a species...
  77. pmc Arabidopsis kinesin KP1 specifically interacts with VDAC3, a mitochondrial protein, and regulates respiration during seed germination at low temperature
    Xue yong Yang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China
    Plant Cell 23:1093-106. 2011
    ..kinesin, Kinesin-like protein 1 (KP1; At KIN14 h), is involved in respiratory regulation during seed germination at a low temperature...
  78. ncbi Phytotoxicity of nanoparticles: inhibition of seed germination and root growth
    Daohui Lin
    Department of Environmental Science, Zhejiang University, Hangzhou 310028, China
    Environ Pollut 150:243-50. 2007
    ..of five types of nanoparticles (multi-walled carbon nanotube, aluminum, alumina, zinc, and zinc oxide) on seed germination and root growth of six higher plant species (radish, rape, ryegrass, lettuce, corn, and cucumber) were ..
  79. pmc Characterization of the entire cystatin gene family in barley and their target cathepsin L-like cysteine-proteases, partners in the hordein mobilization during seed germination
    Manuel Martinez
    Centro de Biotecnología y Genómica de Plantas, Universidad Politecnica de Madrid, Campus Montegancedo Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcon, Madrid, Spain
    Plant Physiol 151:1531-45. 2009
    ..was inferred from their common implication as counterparts of mobilization of storage proteins upon barley seed germination. The opposite pattern of transcription expression in gibberellin-treated aleurones presented by inhibitors and ..
  80. ncbi Loss of function of four DELLA genes leads to light- and gibberellin-independent seed germination in Arabidopsis
    Dongni Cao
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos 138673, Singapore
    Planta 223:105-13. 2005
    ..This fact suggests that (1) gibberellin (GA) is absolutely necessary for the germination of an intact seed and (2) the ga1-3 mutant can be used as a good system to identify factors that repress seed ..
  81. pmc 12-oxo-phytodienoic acid accumulation during seed development represses seed germination in Arabidopsis
    Anuja Dave
    Centre for Novel Agricultural Products, Department of Biology, University of York, Heslington, York YO105DD, United Kingdom
    Plant Cell 23:583-99. 2011
    ..disrupted in steps of peroxisomal β-oxidation have previously been reported to exhibit a severe block on seed germination. Oxylipin analysis on cts, acyl CoA oxidase1 acyl CoA oxidase2 (acx1 acx2), and keto acyl thiolase2 dry seeds ..
  82. pmc Gibberellin mobilizes distinct DELLA-dependent transcriptomes to regulate seed germination and floral development in Arabidopsis
    Dongni Cao
    Functional Genomics Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore 138673
    Plant Physiol 142:509-25. 2006
    ..In contrast, the ga1-3 gai-t6 rga-t2 rgl1-1 rgl2-1 mutant confers GA-independent seed germination and floral development...
  83. pmc Far-red light inhibits germination through DELLA-dependent stimulation of ABA synthesis and ABI3 activity
    Urszula Piskurewicz
    Département de Biologie Végétale, Universite de Geneve, Geneve 4, Switzerland
    EMBO J 28:2259-71. 2009
    Under the canopy, far-red (FR) light represses seed germination by inactivating phytochrome photoreceptors. This elicits a decrease in gibberellins (GA) levels and an increase in abscisic acid (ABA) levels...
  84. pmc Analysis of natural allelic variation at seed dormancy loci of Arabidopsis thaliana
    Carlos Alonso-Blanco
    Laboratory of Genetics, Graduate School of Experimental Plant Science, Wageningen University, The Netherlands
    Genetics 164:711-29. 2003
    ..the after-ripening requirement measured as the number of days of seed dry storage required to reach 50% germination. Thus, seven QTL were identified and named delay of germination (DOG) 1-7...
  85. pmc Mutations of genes in synthesis of the carotenoid precursors of ABA lead to pre-harvest sprouting and photo-oxidation in rice
    Jun Fang
    State Key Laboratory of Plant Genomics and National Centre for Plant Gene Research, Beijing 100101, China
    Plant J 54:177-89. 2008
    ..These results suggest that the impairment of carotenoid biosynthesis causes photo-oxidation and ABA-deficiency phenotypes, of which the latter is a major factor controlling the PHS trait in rice...
  86. pmc The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans
    Martin Eisendle
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Eukaryot Cell 5:1596-603. 2006
    ..growth under iron-depleted conditions and a higher iron demand under iron-replete conditions, (ii) delayed germination under iron-depleted conditions, (iii) increased sensitivity of conidia to oxidative stress, and (iv) ..
  87. ncbi Flavonoids as developmental regulators
    Loverine P Taylor
    511 Abelson Hall, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4234, USA
    Curr Opin Plant Biol 8:317-23. 2005
    ..The multiple cellular roles of flavonoids can reflect their chemical diversity, or might suggest the existence of cellular targets shared between many of these seemingly disparate processes...
  88. ncbi Stored and neosynthesized mRNA in Arabidopsis seeds: effects of cycloheximide and controlled deterioration treatment on the resumption of transcription during imbibition
    Mitsuhiro Kimura
    Department of Cell and Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, ON M5S3B2, Canada
    Plant Mol Biol 73:119-29. 2010
    ..resembled one another, suggesting that patterns of stored mRNA do not reflect either the degree of dormancy or germination potential, but rather reflect the developmental context, such as seed maturation...
  89. ncbi The Dof protein DAG1 mediates PIL5 activity on seed germination by negatively regulating GA biosynthetic gene AtGA3ox1
    Stefano Gabriele
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Plant J 61:312-23. 2010
    ..shown that inactivation of the gene encoding the Arabidopsis thaliana transcription factor DOF AFFECTING GERMINATION 1 (DAG1) renders seed germination more sensitive to both phytochrome B (phyB) and gibberellins (GA)...
  90. ncbi ROS production and protein oxidation as a novel mechanism for seed dormancy alleviation
    Krystyna Oracz
    Department of Plant Physiology, Warsaw Agricultural University, Nowoursynowska 159, 02 776 Warsaw, Poland
    Plant J 50:452-65. 2007
    ..dry state, known as after-ripening, is associated with an alleviation of embryonic dormancy allowing subsequent germination at suboptimal temperatures...
  91. ncbi The earliest stages of adaptation in an experimental plant population: strong selection on QTLS for seed dormancy
    Xueqing Huang
    Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, 50829 Cologne, Germany
    Mol Ecol 19:1335-51. 2010
    ..These QTLs colocated with QTLs for germination phenology when seeds were dispersed following a schedule of a typical winter annual, and they were detected in ..
  92. pmc H2O2 mediates the regulation of ABA catabolism and GA biosynthesis in Arabidopsis seed dormancy and germination
    Yinggao Liu
    State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian, Shandong, China
    J Exp Bot 61:2979-90. 2010
    ..of ABA catabolism and GA biosynthesis during seed imbibition and thus exerted control over seed dormancy and germination. As seen by quantitative RT-PCR (QRT-PCR), H(2)O(2) up-regulated ABA catabolism genes (e.g...
  93. pmc The Arabidopsis aleurone layer responds to nitric oxide, gibberellin, and abscisic acid and is sufficient and necessary for seed dormancy
    Paul C Bethke
    United States Department of Agriculture, Agricultural Research Service, Department of Horticulture, University of Wisconsin, Madison, Wisconsin 53706, USA
    Plant Physiol 143:1173-88. 2007
    ..components of the Arabidopsis seed that contribute to seed dormancy and to learn more about how dormancy and germination are regulated in this species. The aleurone layer was found to be the primary determinant of seed dormancy...
  94. pmc The DELLA domain of GA INSENSITIVE mediates the interaction with the GA INSENSITIVE DWARF1A gibberellin receptor of Arabidopsis
    Björn C Willige
    Department of Developmental Genetics, Center for Plant Molecular Biology, Tubingen University, 72076 Tubingen, Germany
    Plant Cell 19:1209-20. 2007
    Gibberellic acid (GA) promotes seed germination, elongation growth, and flowering time in plants...
  95. pmc The magnesium-chelatase H subunit binds abscisic acid and functions in abscisic acid signaling: new evidence in Arabidopsis
    Fu Qing Wu
    State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100094, China
    Plant Physiol 150:1940-54. 2009
    ..protein (GFP) in wild-type plants conferred ABA hypersensitivity in all major ABA responses, including seed germination, postgermination growth, and stomatal movement, and the expression of the same truncated proteins fused with ..
  96. ncbi Epoxycarotenoid cleavage by NCED5 fine-tunes ABA accumulation and affects seed dormancy and drought tolerance with other NCED family members
    Anne Frey
    Institut Jean Pierre Bourgin, UMR1318, INRA, AgroParisTech, F 78026 Versailles Cedex, France
    Plant J 70:501-12. 2012
    ..In contrast to nced6 and nced9, however, nced5 mutation did not affect the gibberellin required for germination. In vegetative tissues, combining nced5 and nced3 mutations reduced vegetative growth, increased water loss ..
  97. ncbi MicroRNA402 affects seed germination of Arabidopsis thaliana under stress conditions via targeting DEMETER-LIKE Protein3 mRNA
    Joo Yeol Kim
    Department of Plant Biotechnology, Agricultural Plant Stress Research Center and Biotechnology Research Institute, College of Agriculture and Life Sciences, Chonnam National University, 300 Yongbong Dong, Buk Gu, Gwangju, 500 757 Korea
    Plant Cell Physiol 51:1079-83. 2010
    ..Overexpression of miR402 accelerated the seed germination and seedling growth of Arabidopsis under salt stress conditions, while its overexpression promoted only seed ..
  98. ncbi Gene expression profiles of Arabidopsis Cvi seeds during dormancy cycling indicate a common underlying dormancy control mechanism
    Cassandra S C Cadman
    Warwick HRI, Warwick University, Wellesbourne, Warwick CV35 9EF, UK
    Plant J 46:805-22. 2006
    ..greatly reduced gene expression associated with protein synthesis, potentially controlling the completion of germination. A core set of 442 genes were identified that had higher expression in all dormant states compared with after-..
  99. ncbi Understanding the role of H(2)O(2) during pea seed germination: a combined proteomic and hormone profiling approach
    Gregorio Barba-Espín
    Grupo de Biotecnología de Frutales, CEBAS CSIC, Campus Espinardo, Murcia, Spain
    Plant Cell Environ 34:1907-19. 2011
    ..we showed that the treatment of pea seeds in the presence of hydrogen peroxide (H(2)O(2)) increased germination performance as well as seedling growth...
  100. ncbi CAP2 enhances germination of transgenic tobacco seeds at high temperature and promotes heat stress tolerance in yeast
    Rakesh Kumar Shukla
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi, India
    FEBS J 276:5252-62. 2009
    ..Here, we report that, in addition, the CAP2-transgenic tobacco seeds also exhibit higher germination efficiency at high temperature and show higher expression levels of genes for tobacco heat shock proteins and a ..
  101. ncbi Thioredoxin reduction alters the solubility of proteins of wheat starchy endosperm: an early event in cereal germination
    Joshua H Wong
    Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, CA 94720, USA
    Plant Cell Physiol 45:407-15. 2004
    ..and increasing protease sensitivity, reduction by thioredoxin alters protein solubility, thereby promoting processes of the grain starchy endosperm, notably the mobilization of reserves during germination and seedling development.

Research Grants64

  1. Immunobiology of Bacillus anthracis Spore-Host Interactions
    JOHN FRANKLIN KEARNEY; Fiscal Year: 2012
    ..on dispersal of its spores in the environment, entrance into the body, spore uptake by the human host cells, germination of the spores in the host and the pathological consequences of the host response to the toxins elaborated by ..
  2. Genetics and visualization of innate host response to C. albicans infection in vi
    Robert T Wheeler; Fiscal Year: 2012
    ..indicates that macrophages in their natural context have an enhanced ability to limit proliferation and germination of C. albicans. We hypothesize that macrophages limit filamentous growth of C...
  3. Shifts in the Gastrointestinal Metabolome During Clostridium difficile Infection
    CASEY THERIOT; Fiscal Year: 2013
    ..Subsequently, we demonstrated that C. difficile could utilize many of these metabolites for in vitro germination and growth. The central hypothesis is that the availability of specific nutrients that support C...
  4. Role and function of Spx paralogs of Bacillus anthracis
    PETER A ZUBER; Fiscal Year: 2012
    ..The B. anthracis genes that are induced in the macrophage upon germination include the ortholog of the global transcriptional regulator, Spx, an ArsC protein family member, which in Gram-..
  5. Initiation of the Immune Response to Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Unchecked spore germination in the lung leads to invasive aspergillosis (IA), a major cause of infectious morbidity and mortality in immune ..
  6. Structure and Function of the B. anthracis Exosporium
    Charles L Turnbough; Fiscal Year: 2010
    ..of the exosporium proteins, focusing on their critical roles in exosporium assembly, spore viability, germination, and virulence...
  7. Protective Effects of Anti-BclA Antibodies in Bacillus anthracis Infection
    JUAN B RODRIGUEZ BARRANTES; Fiscal Year: 2013
    ..The mechanisms that have yet to be completely elucidated include uptake by the human host cells, germination of the spores in the host and the pathological consequences of the host response to the toxins elaborated by ..
  8. INITIAL EVENTS IN PHOTORECEPTOR SIGNALING
    Joanne Chory; Fiscal Year: 2013
    ..Light influences every developmental transition from seed germination to flowering, having particularly dramatic effects on the morphogenesis of seedlings where it alters the ..
  9. Control of Aspergillus fumigatus polarized growth through regulation of Ras prote
    Jarrod Fortwendel; Fiscal Year: 2013
    ..The conidia of A. fumigatus are inhaled and undergo germination, giving way to sustained polarized growth. This highly polarized tip growth allows A...
  10. The role of calcium-DPA in the virulence of Bacillus anthracis spores
    ERNESTO V ABEL-SANTOS; Fiscal Year: 2013
    ..anthracis spore germination. The Ca-DPA depot will be localized inside macrophages when B. anthracis spores germinate in the host...
  11. INTEGRATION OF DNA DAMAGE RESPONSES WITH IMMUNE DEVELOPMENT AND FUNCTION
    Jeffrey J Bednarski; Fiscal Year: 2013
    ..These tools will be essential for completion of the outlined experiments and for the germination of an independent research program...
  12. Dissection of Macrophage Antifungal Activity against Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Humans inhale ubiquitous Aspergillus fumigatus conidia on a daily basis. Conidial germination into tissue-invasive hyphae leads to invasive aspergillosis (IA), a devastating cause of infectious morbidity ..
  13. High-density lipoprotein and A. fumigatus pathogenesis
    David S Askew; Fiscal Year: 2013
    ..In vitro studies revealed that apoA-I binds to AF conidia and impairs germination, suggesting antifungal activity...
  14. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2010
    ..In addition, we have published a proteome of Bacillus anthracis by identifying spore proteins associated with germination and early outgrowth...
  15. Regulation of akinete differentiation in Nostoc punctiforme
    Michael L Summers; Fiscal Year: 2013
    ..Understanding akinete formation may identify targets to inhibit their formation or germination, thereby reducing survival and the extent of subsequent toxic blooms by toxic cyanobacteria.
  16. Innate Immune Defense against Clostridium Difficile Infection
    Eric G Pamer; Fiscal Year: 2013
    ..difficile infection will be measured. These studies will identify microbial populations that inhibit germination and/or vegetative growth of C. difficile...
  17. Role of Bile Acids in Human Susceptibiity to Clostridium difficile Infection
    JOSEPH AARON SORG; Fiscal Year: 2013
    ..Previous work has shown that C. difficile spore germination is dependent on certain bile acids...
  18. Molecular Mechanisms of Phytochrome Signaling
    JOHN CLARK LAGARIAS; Fiscal Year: 2013
    ..Phytochromes are key regulators for triggering seed germination, initiating early development of the seedling, and inducing flowering (sexual development)...
  19. Bacillus anthracis Targets Involved in Chemokine-Mediated Antimicrobial Activity
    Molly A Hughes; Fiscal Year: 2013
    ..that the interferon-inducible CXC chemokines, CXCL9, CXCL10, and CXCL11, block Bacillus anthracis spore germination, reduce spore viability, and kill vegetative cells, with CXCL10 being the most effective...
  20. The Role of Lung Epithelium in B. anthracis Pathogenesis
    Yi Xu; Fiscal Year: 2010
    ..e., intracellular germination is a prerequisite to switching on a "translocation pathway"...
  21. Mechanism of spore germination
    Philip C Hanna; Fiscal Year: 2012
    ..b>Germination is an essential early event for numerous infections including: anthrax (B. anthracis), C...
  22. 2010 Cell and Molecular Fungal Biology; Gordon Research Conference
    John W Taylor; Fiscal Year: 2010
    ..to the prevention of fungal disease by illuminating basic features of fungal development, including spore germination, colony establishment, growth, and reproduction...
  23. A systems level analysis of spore coat assembly in Bacillus subtilis
    Patrick Eichenberger; Fiscal Year: 2012
    ..Bacillus anthracis, are inhaled or ingested as spores and resume growth and toxin production in the host after germination. The spore protein coat, which encapsulates the spore, is an important factor in the infectious cycle, because ..
  24. Development and Testing of Recombinant Clostridia for Cancer Therapy
    ERIC SCOTT contact GILLITZER; Fiscal Year: 2010
    ..Following i.v. injection of spores of the recombinant clostridia, germination of the spores and production of the prodrug activating enzyme occurs solely in the tumors...
  25. Anaerobic Bacteria as Oncopathic Agents for Pancreatic Cancer
    Savio Woo; Fiscal Year: 2009
    ..when administered intravenously in mice bearing an orthotopic model of pancreatic cancer, were capable of germination and proliferation in the hypoxic tumor regions with oncopathic effects...
  26. Echinacea: Standardized Product & Supply Provision
    Xiping Wang; Fiscal Year: 2004
    ..methodology that is commercially viable; 3) condition and materials used in the greenhouse for high-yield germination; 4) soil condition and materials used for quality raw material; 5) alternatives to pesticides/herbicides for ..
  27. Anthrax vaccination by targeting spore germination
    Chun Ming Huang; Fiscal Year: 2005
    b>Germination occurs as an upstream event during the life cycle of Bacillus anthracis...
  28. ASPERGILLUS ELASTASE, A POTENTIAL VIRULENCE FACTOR
    JUDITH RHODES; Fiscal Year: 1990
    ..The histopathology of the lesion has been well described: following germination, the hyphae elongate and spread rapidly, penetrating vessels and bronchi in their path...
  29. STRATEGIES FOR INACTIVATING BACILLUS ANTHRACIS SPORES
    Arthur Aronson; Fiscal Year: 2003
    ..Some features of the B. anthracis spore such as germination response and spore coat structure have been shown to vary with the conditions used for spore formation...
  30. Immunoprotective monoclonals to B. anthracis spores
    ALISON O BRIEN; Fiscal Year: 2003
    ..edema factor and lethal factor) actually bind to the surface of spores and decrease the level of spore germination, taken with the fact that formaldehyde-inactivated spores can serve as a protective vaccine against anthrax in ..
  31. Nisin as a decontaminant for B. anthracis spores on human skin
    Kenneth Alibek; Fiscal Year: 2007
    ..is a peptide antibiotic that is commonly used as a food preservative and has the unique capacity to prevent the germination and outgrowth of bacterial spores...
  32. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2009
    ..BCR appear to be physiologically identical to normal spores except for performing as self reporters of initial germination events...
  33. SYSTEMIC LYMPH NODE SPECIFIC AGENTS
    MIKHAIL PAPISOV; Fiscal Year: 2003
    ..Thus, the primary site of germination and development of weaponized biological agents will be sufficiently saturated with drugs to prevent or stop ..
  34. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2007
    ..BCR appear to be physiologically identical to normal spores except for performing as self-reporters of initial germination events...
  35. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..and host-pathogen interactions in invasive aspergillosis using a monoclonal antibody (MAb 318) that inhibits germination, the phase transition from the spore form to hyphal form that is required for invasion, and prolongs survival ..
  36. NEW TREATMENT FOR AMOEBIC KERATITIS
    CLARENCE VILLEMEZ; Fiscal Year: 2001
    ..here, no other receptor of this type has been identified, even from the most studied systems, bacterial spore germination. They have identified a receptor, ESP, which controls absolutely the encystment and excystment of Acanthamoeba ..
  37. REGULATION OF SYNTHESIS OF A HORMONE INDUCED PROTEIN
    GLENN GALAU; Fiscal Year: 1991
    ..of Arabidopsis defective in the ability of embryos to survive normal desiccation, but rescuable by precocious germination. These are predicted to be deficient in Lea function and as such should help elucidate both the regulation and ..
  38. MEMBRANE FUNCTION DURING GERMINATION OF CANDIDA ALBICANS
    RONALD CIHLAR; Fiscal Year: 1990
    The effect of perturbing membrane biogenesis on yeast cell germination and chitin biosynthesis will be studied in Candida albicans...
  39. Chemical Structure of Anthrax Spore Polysaccharide
    Julia Wang; Fiscal Year: 2005
    ..EPS remains intact throughout the entire germination stage from dormant spores to newly transformed vegetative bacteria...
  40. Bacillus anthracis Spores: Initiation of Germination
    TERRY KRULWICH; Fiscal Year: 2003
    An essential early step in the initiation of anthrax in the mammalian host is the germination of the Bacillus anthracis (endo)spores that have been engulfed by macrophages...
  41. GENETIC DISSECTION OF PHYTOCHROME B SIGNALLING
    Jason Reed; Fiscal Year: 1999
    ..Environmental conditions influence commitment to developmental events such as seed germination and flowering, as well as adjustments of growth leading to morphological variation, such as stem elongation, ..
  42. Encephalitozoon intestinalis Spore Adherence to Host
    James Hayman; Fiscal Year: 2004
    ..that spore adherence may be mediated by two different mechanisms While the optimal conditions for spore germination are not known, it seems logical that spore adherence may be a critical step in the infection process Thus, the ..
  43. IN VITRO DELIVERABILITY OF ANTI-ANTHRAX DISCOVERY LEADS
    R Porter; Fiscal Year: 2000
    ..A novel enzyme target, NAD synthetase (NADs), has been identified that is critical to the germination and vegetative life cycle of B...
  44. CHARACTERIZATION OF B ANTHRACIS EXOSPORIUM PROTEINS
    CHARLES TURNBOUGH; Fiscal Year: 2004
    ..evidence suggests that they will contribute significantly to key spore properties such as structure, viability, germination, infectivity, and virulence. In the proposed research, we will identify the proteins in the B...
  45. Germination of Bacillus anthracis Spores in Macrophages
    Daoguo Zhou; Fiscal Year: 2004
    ..Recent studies have begun to explore factors that are responsible for the germination of B. anthracis spores and their subsequent survival in the macrophages...
  46. KITP Interdisciplinary Biology Initiative
    Boris I Shraiman; Fiscal Year: 2013
    ..The programs will be organized with the emphasis on germination of interdisciplinary collaborations and will include an extensive tutorial component to provide physical and ..
  47. Hand-Held System to Detect Anthrax Spores in Bio-defense
    BERTRAND LEMIEUX; Fiscal Year: 2003
    ..spore disruption and nucleic acid extraction techniques by exploring a combination of approaches, including germination induction and mechanical disruption...
  48. GENE STRUCTURE AND EF-1A IN THE FUNGUS MUCOR
    PAUL SYPHERD; Fiscal Year: 1991
    ..During the course of spore germination the specific acitivity increases 6 to 9-fold...
  49. RAS GENE FUNCTION IN FUNGAL DIMORPHISM
    JUDITH MEDOFF; Fiscal Year: 1990
    ..cyclase activity and at least one functional RAS gene is essential for cell viability, proliferation and spore germination. To determine whether ras function is involved in the differentiation of H...
  50. A NEW PROTEIN MODIFICATION PATHWAY IN EUKARYOTES
    Daniel Finley; Fiscal Year: 2004
    ..mutants exhibit a delay in the resumption of growth after stationary phase and a related phenotype of delayed germination. Rub2 exhibits scant sequence identity to ubiquitin...
  51. Therapeutic Targeting of the Infectious Path of Anthrax
    ANTHONY SCOTTO; Fiscal Year: 2003
    ..It is, however, better characterized as a disease that recruits macrophages, first alveolar macrophages for its germination and then systemic macrophages (RES) to complete its biochemical pathogenesis...
  52. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2004
    This proposal investigates the first hours of anthrax infections; in vivo germination of the Bacillus anthracis endospore, macrophage survival, growth and escape of the vegetative bacilli...
  53. Early events during infection with anthrax
    Alan Cross; Fiscal Year: 2006
    ..Specific Aim I will add germination-deficient BA spore (to avoid vegetative form contamination) to human embryonal kidney cells transfected with ..
  54. Monoclonal antibodies for invasive aspergillosis
    Marta Feldmesser; Fiscal Year: 2003
    ..fumigatus DPP V; 2. To generate and characterize in vitro MAbs to A. fumigatus that prevent germination; 3. To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis...
  55. Spore Dispersal and Germination in Stachybotrys
    NICHOLAS MONEY; Fiscal Year: 2007
    ..Thirdly, spore germination will be assessed using a multi-well plate method in relation to water availability, substrate composition, ..
  56. FUNCTIONAL STUDIES OF HUMAN AND SOYBEAN LIPOXYGENASE
    THEODORE HOLMAN; Fiscal Year: 2001
    ..The activity of the enzyme has been implicated in plant germination, human asthma and arthritis. The active site of the enzyme contains an essential iron atom...
  57. MECHANISMS OF ETHANOL TOXICITY IN DICTYOSTELIUM
    Gad Shaulsky; Fiscal Year: 2001
    ..Consequences of the genetic manipulations can be monitored as changes in multicellular development and in spore germination, processes that are highly dependent on cAMP signal transduction...
  58. Rapid Determination of Viability of Anthrax Spores
    Rashid Bashir; Fiscal Year: 2003
    ..Micro-devices will be developed to rapidly detect the viability of the spores upon germination within one doubling cycle of the organisms, providing an electronic output...
  59. High Throughput and Virtual Screening for Human 12-LO, 15-LO-1, and 15-LO-2 Inhib
    THEODORE HOLMAN; Fiscal Year: 2007
    ..In plants they are involved in germination and senescence...
  60. Adenovirus-vectored nasal anthrax vaccine
    DE CHU TANG; Fiscal Year: 2005
    ..An Ad vector encoding lnhAmut will be investigated for its potential to arrest spore germination by eliciting an immune response that neutralizes secretory immune inhibitor A...
  61. Germination of Bacillus subtilis spores
    MELISA WILLBY; Fiscal Year: 2005
    ..We will use Bacillus subtilis as a model for germination. Our goal is to identify the complete repertoire of proteins known to be involved in germination and to ..
  62. STRUCTURE AND FUNCTION OF THE LIGHT SWITCH PHYTOCHROME
    Pill Soon Song; Fiscal Year: 2000
    ..transcribed in the dark and another involving organelle movement and morphological/circadian rhythms such as germination, flowering, etc, some of which may be preceded by transcriptional regulation...
  63. Development of Genetic Tools for Clostridium botulinum
    Eric Johnson; Fiscal Year: 2005
    ..physiological factors that control growth and toxin production, pathogenesis, and developmental processes unique to clostridia and related organisms including endospore formation, resistance, germination and outgrowth.
  64. Function of the Bacillus anthracis Spore Carboydrate
    George Stewart; Fiscal Year: 2005
    ..defects in spore formation and the spores from these mutants characterized for their resistance properties and germination efficiency in vitro...