dark adaptation

Summary

Summary: Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.

Top Publications

  1. ncbi Photoreceptor degeneration and dysfunction in aging and age-related maculopathy
    Gregory R Jackson
    Department of Ophthalmology, School of Medicine, University of Alabama, Birmingham, AL 35294 0009, USA
    Ageing Res Rev 1:381-96. 2002
  2. ncbi Adaptation in vertebrate photoreceptors
    G L Fain
    Department of Physiological Science, University of California, Los Angeles, California 90095 1527, USA
    Physiol Rev 81:117-151. 2001
  3. ncbi In vivo studies of signaling in rod pathways of the mouse using the electroretinogram
    J G Robson
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Vision Res 44:3253-68. 2004
  4. pmc The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses
    Bo Chang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Vis Neurosci 23:11-24. 2006
  5. ncbi Correlation of regenerable opsin with rod ERG signal in Rpe65-/- mice during development and aging
    Baerbel Rohrer
    Department of Ophthalmology Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
    Invest Ophthalmol Vis Sci 44:310-5. 2003
  6. ncbi Clinical variability among patients with incomplete X-linked congenital stationary night blindness and a founder mutation in CACNA1F
    K M Boycott
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Alta
    Can J Ophthalmol 35:204-13. 2000
  7. ncbi A preliminary trial to determine whether prevention of dark adaptation affects the course of early diabetic retinopathy
    G B Arden
    Department of Optometry and Visual Science, School of Community and Health Sciences, City University, London, UK
    Eye (Lond) 24:1149-55. 2010
  8. ncbi The electroretinographic diagnosis of the incomplete form of congenital stationary night blindness
    F Tremblay
    Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada
    Vision Res 35:2383-93. 1995
  9. ncbi Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram
    Christina Zeitz
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Invest Ophthalmol Vis Sci 46:4328-35. 2005
  10. ncbi Visual function tests as potential biomarkers in age-related macular degeneration
    Peter N Dimitrov
    Center for Eye Research Australia, The University of Melbourne, The Royal Victorian, Eye and Ear Hospital RVEEH, Victoria, Australia
    Invest Ophthalmol Vis Sci 52:9457-69. 2011

Detail Information

Publications276 found, 100 shown here

  1. ncbi Photoreceptor degeneration and dysfunction in aging and age-related maculopathy
    Gregory R Jackson
    Department of Ophthalmology, School of Medicine, University of Alabama, Birmingham, AL 35294 0009, USA
    Ageing Res Rev 1:381-96. 2002
    ..sensitivity is more prominent than a decline in photopic (cone-mediated) sensitivity, and the time course of dark adaptation of rods slows dramatically...
  2. ncbi Adaptation in vertebrate photoreceptors
    G L Fain
    Department of Physiological Science, University of California, Los Angeles, California 90095 1527, USA
    Physiol Rev 81:117-151. 2001
    ..This form of desensitization, called bleaching adaptation (the recovery from which is known as dark adaptation), seems largely to be due to an activation of the transduction cascade by some form of bleached pigment...
  3. ncbi In vivo studies of signaling in rod pathways of the mouse using the electroretinogram
    J G Robson
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Vision Res 44:3253-68. 2004
    ..b) To estimate the level of this threshold and the amplitude of the continuous noise which it can serve to reduce. (c) To identify the location of the threshold mechanism in the rod to rod bipolar cell pathway...
  4. pmc The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses
    Bo Chang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Vis Neurosci 23:11-24. 2006
    ..Further, the nob2 mouse represents a model system in which to define the signals that guide synapse formation and/or maintenance in the OPL...
  5. ncbi Correlation of regenerable opsin with rod ERG signal in Rpe65-/- mice during development and aging
    Baerbel Rohrer
    Department of Ophthalmology Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
    Invest Ophthalmol Vis Sci 44:310-5. 2003
    ..This project was designed to determine the amount of regenerable opsin in Rpe65-/- mice during development and aging, and to examine the function of this rhodopsin by electroretinography (ERG)...
  6. ncbi Clinical variability among patients with incomplete X-linked congenital stationary night blindness and a founder mutation in CACNA1F
    K M Boycott
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Alta
    Can J Ophthalmol 35:204-13. 2000
    ..We assessed the clinical variability in the expression of the incomplete CSNB phenotype in a subgroup of patients of Mennonite ancestry with the same founder mutation...
  7. ncbi A preliminary trial to determine whether prevention of dark adaptation affects the course of early diabetic retinopathy
    G B Arden
    Department of Optometry and Visual Science, School of Community and Health Sciences, City University, London, UK
    Eye (Lond) 24:1149-55. 2010
    ..This study was designed to determine whether a new form of treatment of diabetic retinopathy (DR) was acceptable to patients and whether reduction in the maximal activity of rods in diabetes could affect the progress of DR...
  8. ncbi The electroretinographic diagnosis of the incomplete form of congenital stationary night blindness
    F Tremblay
    Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada
    Vision Res 35:2383-93. 1995
    ..We propose that the defect, which interferes marginally with the neuronal flow of information, lies in the structures responsible for the building of the b-wave...
  9. ncbi Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram
    Christina Zeitz
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Invest Ophthalmol Vis Sci 46:4328-35. 2005
    ..Mice lacking the metabotropic glutamate receptor 6 (Grm6) have a defect in signal transmission from the photoreceptors to ON-bipolar cells. In the current study, the human orthologue (GRM6) was screened as a likely candidate for arCSNB...
  10. ncbi Visual function tests as potential biomarkers in age-related macular degeneration
    Peter N Dimitrov
    Center for Eye Research Australia, The University of Melbourne, The Royal Victorian, Eye and Ear Hospital RVEEH, Victoria, Australia
    Invest Ophthalmol Vis Sci 52:9457-69. 2011
    ..To evaluate the potential of psychophysical assessments of retinal function to provide diagnostic biomarkers of early age-related macular degeneration (AMD)...
  11. pmc Regression of early diabetic macular oedema is associated with prevention of dark adaptation
    G B Arden
    School of Community and Health Sciences, City University, London, UK
    Eye (Lond) 25:1546-54. 2011
    ..Dark-adapted rods consume oxygen at high rates and light adaptation decreases this oxygen burden and can have therapeutic effects on diabetic macular oedema (DMO)...
  12. ncbi Delays in rod-mediated dark adaptation in early age-related maculopathy
    C Owsley
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 35294 0009, USA
    Ophthalmology 108:1196-202. 2001
    To determine whether there are disturbances in the rod-mediated kinetics of dark adaptation in early age-related maculopathy (ARM).
  13. ncbi Dark adaptation in vitamin A-deficient adults awaiting liver transplantation: improvement with intramuscular vitamin A treatment
    Winsome J Abbott-Johnson
    Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia
    Br J Ophthalmol 95:544-8. 2011
    Although vitamin A deficiency is common in chronic liver disease, limited data exist on impairment of dark adaptation and response to therapy...
  14. ncbi Rod photoreceptor dysfunction in diabetes: activation, deactivation, and dark adaptation
    Joanna A Phipps
    Department of Optometry and Vision Sciences, University of Melbourne, Carlton, Australia
    Invest Ophthalmol Vis Sci 47:3187-94. 2006
    ..function in diabetes in detail by evaluating photoreceptor light activation, deactivation of the photoresponse, and recovery of the photoreceptor after bleaching (dark adaptation) in rats made diabetic with streptozotocin (STZ).
  15. ncbi Study of rod- and cone-driven oscillatory potentials in mice
    Bo Lei
    Department of Veterinary Medicine and Surgery, Mason Eye Institute, and the Department of Biological Engineering, University of Missouri Columbia 65211, USA
    Invest Ophthalmol Vis Sci 47:2732-8. 2006
    ..To characterize rod- and cone-driven oscillatory potentials (OPs) in mice...
  16. ncbi Visual adaptations in the night-active wasp Apoica pallens
    Birgit Greiner
    Department of Cell and Organism Biology, Lund University, Zoology Building, S 22362 Lund, Sweden
    J Comp Neurol 495:255-62. 2006
    ..As the optical sensitivity alone cannot account for the 8 log units intensity difference between day and night, a possible role of neural summation within the first optic ganglion (lamina) of nocturnal hymenopterans is discussed...
  17. ncbi Cone- and rod-mediated dark adaptation impairment in age-related maculopathy
    Cynthia Owsley
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0009, USA
    Ophthalmology 114:1728-35. 2007
    To examine impairment in cone- versus rod-mediated dark adaptation in the parafovea of persons with age-related maculopathy (ARM).
  18. ncbi A comparison of ERG abnormalities in XLRS and XLCSNB
    Keith Bradshaw
    Ophthalmology Department, Addenbrookes Hospital, Cambridge, UK
    Doc Ophthalmol 108:135-45. 2004
    ..The ERG results suggest that the RS1 and CACNA1F gene products have comparable functional consequences and that all three genes may affect multiple retinal sites...
  19. pmc Intra-retinal visual cycle required for rapid and complete cone dark adaptation
    Jin Shan Wang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, Missouri 63110, USA
    Nat Neurosci 12:295-302. 2009
    ..found that the Müller cells in the salamander neural retina promote cone-specific pigment regeneration and dark adaptation that are independent of the pigment epithelium...
  20. pmc Genotype-phenotype correlation in British families with X linked congenital stationary night blindness
    L E Allen
    Eye Department, Addenbrooke s Hospital, Cambridge, UK
    Br J Ophthalmol 87:1413-20. 2003
    ..To correlate the phenotype of X linked congenital stationary night blindness (CSNBX) with genotype...
  21. pmc Toward a unified model of vertebrate rod phototransduction
    R D Hamer
    Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
    Vis Neurosci 22:417-36. 2005
    ..Informative limitations of the model are also discussed...
  22. ncbi Oscillatory potentials and the b-Wave: partial masking and interdependence in dark adaptation and diabetes in the rat
    C J Layton
    Nuffield Laboratory of Ophthalmology, Oxford University, Walton St, Oxford OX2 6AW, UK
    Graefes Arch Clin Exp Ophthalmol 245:1335-45. 2007
    Diabetes inhibits dark adaptation and both processes alter the electroretinogram (ERG) in similar ways...
  23. pmc RP2 and RPGR mutations and clinical correlations in patients with X-linked retinitis pigmentosa
    Dror Sharon
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Am J Hum Genet 73:1131-46. 2003
    ..Furthermore, as the length of the abnormal amino acid sequence following ORF15 frameshift mutations increased, the severity of disease increased...
  24. ncbi Alcohol does not affect dark adaptation or luminance increment thresholds
    Sarah A Khan
    Department of Psychology, The University of Western Ontario, Social Science Centre, Room 6254, London, Ontario, Canada N6A 5C2
    J Stud Alcohol Drugs 68:493-502. 2007
    It has been proposed that alcohol might induce within the retina a state akin to dark adaptation. However, the evidence to support this proposal is quite indirect...
  25. ncbi Nocturnal vision and landmark orientation in a tropical halictid bee
    Eric J Warrant
    Department of Cell and Organism Biology, Zoology Building, University of Lund, Helgonavagen 3, S 22362 Lund, Sweden
    Curr Biol 14:1309-18. 2004
    ..The insensitive optics of apposition eyes are not well suited for nocturnal vision. How well then do nocturnal bees and wasps see? What optical and neural adaptations have they evolved for nocturnal vision?..
  26. ncbi Measuring rod and cone dynamics in age-related maculopathy
    Peter N Dimitrov
    Centre for Eye Research Australia, Department of Ophthalmology, The University of Melbourne, East Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 49:55-65. 2008
    A cathode-ray-tube (CRT) monitor-based technique was used to isolate clinically significant components of dark adaptation. The utility of the technique in identifying adaptation abnormalities in eyes with age-related maculopathy (ARM) is ..
  27. ncbi Transducin translocation in rods is triggered by saturation of the GTPase-activating complex
    Ekaterina S Lobanova
    Albert Eye Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:1151-60. 2007
    ....
  28. ncbi A naturally occurring rat model of X-linked cone dysfunction
    Yong Hao Gu
    Department of Clinical Aerospace Medicine, Faculty of Aerospace Medicine, The Fourth Military Medical University, 17 Changle Xilu, Xi an, ShannXi 710 032, P R China
    Invest Ophthalmol Vis Sci 44:5321-6. 2003
    ..To describe the electrophysiological, histologic, and hereditary features of a naturally occurring rat model of cone function loss...
  29. ncbi Zinc chelation enhances the sensitivity of the ERG b-wave in dark-adapted skate retina
    S Redenti
    The Graduate Center, CUNY, New York, NY, USA
    Biol Bull 205:213-4. 2003
  30. ncbi Topography of cone dark adaptation deficits in age-related maculopathy
    Allannah J Gaffney
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Optom Vis Sci 88:1080-7. 2011
    Despite widespread agreement that dark adaptation is abnormal in age-related maculopathy (ARM), the optimal retinal location for detection of this deficit is unclear...
  31. ncbi Comparison of the Goldmann-Weekers dark adaptometer and LKC Technologies Scotopic Sensitivity tester-1
    A Y Peters
    Retina Foundation of the Southwest, Dallas, TX, USA
    Doc Ophthalmol 101:1-9. 2000
    The standard for dark adaptation has long been the Goldmann-Weekers Dark Adaptometer(Haag-Streit). More recently, portable, relatively inexpensive LED-based dark adaptometers have become commercially available...
  32. ncbi Aviation-related respiratory gas disturbances affect dark adaptation: a reappraisal
    Desmond M Connolly
    QinetiQ Centre for Human Sciences, Cody Technology Park, Ively Road, Farnborough, Hampshire GU14 0LX, UK
    Vision Res 46:1784-93. 2006
    This study examined the time course of early scotopic threshold sensitivity during dark adaptation under mild to moderate hypoxia, moderate hypocapnia and hyperoxia, measuring detection time displacement relative to normoxia...
  33. ncbi Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse
    Maxim Sokolov
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Biol Chem 279:19149-56. 2004
    ..This increased solubility of transducin would make it more susceptible to translocation from the outer segments...
  34. ncbi Retinal dysfunction in cancer-associated retinopathy is improved by Ca(2+) antagonist administration and dark adaptation
    H Ohguro
    Department of Ophthalmology, Hirosaki University School of Medicine, Japan
    Invest Ophthalmol Vis Sci 42:2589-95. 2001
    ....
  35. ncbi Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation
    Oliver Rinner
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland Institute for Molecular Systems Biology, Swiss Federal Institute of Technology ETH, CH 8093 Zurich, Switzerland
    Neuron 47:231-42. 2005
    ....
  36. ncbi Values of electroretinogram responses according to axial length
    C A Westall
    Department of Ophthalmology, University of Toronto and The Hospital for Sick Children, Ontario, Canada
    Doc Ophthalmol 102:115-30. 2001
    ..We provide relative slope and intercept values, allowing labs to derive expected ERG amplitudes according to axial length. These derivations are valid for persons with no retinopathy...
  37. pmc Oxygen consumption and distribution in the Long-Evans rat retina
    Jennifer C M Lau
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
    Exp Eye Res 102:50-8. 2012
    ..The average PO(2) across the inner retina (P(IR)) was not different in dark adaptation (25.4 ± 4.8 mmHg) and light adaptation (28.8 ± 5.4 mmHg) when measured from PO(2) profiles...
  38. pmc Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice
    Jie Fan
    Department of Ophthalmology, Medical University of South Carolina, Charleston 29425, USA
    J Physiol 568:83-95. 2005
    ..Both also have shorter outer segments and a lower free-Ca2+ concentration. These experiments provide the first quantitative measurement of opsin activation in physiologically responding mammalian rods...
  39. ncbi Ocular findings in the Laurence-Moon-Bardet-Biedl syndrome
    R Riise
    Department of Ophthalmology, Central Hospital of Hedmark, Hamar, Norway
    Acta Ophthalmol Scand 74:612-7. 1996
    ..RESULTS: Full-field electroretinograms were obtained in 36 of the individuals and were abnormal in all. The dark adaptation thresholds were elevated by on average 3.5 log units...
  40. ncbi Standard full-field electroretinography in healthy preterm infants
    Adriana Berezovsky
    Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
    Doc Ophthalmol 107:243-9. 2003
    ..contact lens electrode from the anesthetized cornea in one eye, through a fully dilated pupil after 30 min of dark adaptation. The standard ISCEV protocol was used and the following responses were recorded: rod, maximal, oscillatory ..
  41. ncbi Full-field electroretinograms in individuals with the Laurence-Mood-Bardet-Biedl syndrome
    R Riise
    Department of Ophthalmology, Central Hospital of Hedmark, Hamar, Norway
    Acta Ophthalmol Scand 74:618-20. 1996
    ..There is no intrafamilial variability of the electroretinograms in affected siblings...
  42. pmc Persistent activation of transducin by bleached rhodopsin in salamander rods
    H R Matthews
    Physiological Laboratory, University of Cambridge, United Kingdom
    J Gen Physiol 108:557-63. 1996
    ..This observation suggests that a form of rhodopsin which persists long after bleaching can activate transducin much as does photoisomerized rhodopsin, although with considerably lower gain...
  43. ncbi Frequency spectrum and amplitude analysis of dark- and light-adapted oscillatory potentials in albino mouse, rat and rabbit
    Keqing Zhang
    Department of Veterinary and Surgery, University of Missouri Columbia, Columbia, MO 65211, USA
    Doc Ophthalmol 115:85-93. 2007
    ..In order to acquire the complete OP responses from the ERG signals, it is necessary to determine the OP frequency spectrum. In this study, the lower end cutoff frequency was set at 40 Hz in mice, 65 Hz in rats and rabbits...
  44. ncbi Fifty years of dark adaptation 1961-2011
    Tom Reuter
    Department of Biosciences, University of Helsinki, PO Box 65 Viikinkaari 1, FI 00014 Helsinki, Finland
    Vision Res 51:2243-62. 2011
    ..To date, in Vision Research alone, around 500 papers related to light/dark adaptation have been published; this review tries to follow up just a few discussions within the field of vertebrate ..
  45. ncbi Prolonged dark adaptation changes connexin expression in the mouse retina
    Alexandre Hiroaki Kihara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Neurosci Res 83:1331-41. 2006
    ..1, Cx36, Cx37, Cx40, Cx43, Cx45, Cx50, and Cx57) was affected by prolonged dark adaptation. Cx mRNA relative levels were determined in mouse retinas dark adapted for 3 hr, 1 day, and 7 days by using ..
  46. ncbi Oscillatory potentials in the retina: what do they reveal
    L Wachtmeister
    Department of Ophthalmology, , Sweden
    Prog Retin Eye Res 17:485-521. 1998
    ..In this section clinical examples of of the sensitivity of the OPs for revealing early disturbance in neuronal function in different retinal diseases such as pediatric, vascular and degenerative retinopathies are also given...
  47. ncbi Contribution of voltage-gated sodium channels to b- and d-waves of frog electroretinogram under different conditions of light adaptation
    E Popova
    Department of Physiology, Medical Faculty, Medical University, 1431 Sofia, Bulgaria
    Vision Res 50:88-98. 2010
    ....
  48. pmc Relationships among visual cycle retinoids, rhodopsin phosphorylation, and phototransduction in mouse eyes during light and dark adaptation
    Kimberly A Lee
    Department of Biochemistry Box 357350, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 49:2454-63. 2010
    ..and regeneration of rhodopsin, the prototypical G-protein-coupled receptor, each can influence light and dark adaptation. To evaluate their relative contributions, we quantified rhodopsin, retinoids, phosphorylation, and ..
  49. ncbi Retinal function in carriers of Bardet-Biedl syndrome
    Gerald F Cox
    Department of Medicine, Children s Hospital, Boston, Mass, USA
    Arch Ophthalmol 121:804-10. 2003
    ..To test the hypothesis that carriers of Bardet-Biedl syndrome have abnormal rod-mediated responses...
  50. ncbi Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy
    Cynthia Owsley
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 35294 0009, USA
    Invest Ophthalmol Vis Sci 47:1310-8. 2006
    To examine the effect of a short course of high-dose retinol (preformed vitamin A) on dark adaptation in older adults with normal retinal health or early age-related maculopathy (ARM).
  51. ncbi Slow light and dark adaptation of horizontal cells in the Xenopus retina: a role for endogenous dopamine
    P Witkovsky
    Daniel B Kirby Eye Institute, Department of Ophthalmology, New York University Medical Center, NY 10016
    Vis Neurosci 5:405-13. 1990
    ..abstract truncated at 250 words)..
  52. ncbi Quantification of dark adaptation dynamics in retinitis pigmentosa using non-linear regression analysis
    Rokiah Omar
    Department of Optometry, Faculty of Health Sciences, National University of Malaysia, Kuala Lumpur, Malaysia
    Clin Exp Optom 87:386-9. 2004
    Non-linear regression analysis was used to determine dark adaptation indices in people with retinitis pigmentosa and in control subjects.
  53. ncbi The repeatability of the Goldmann-Weekers adaptometer for measuring cone adaptation
    Allannah J Gaffney
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, CF24 4LU, UK
    Doc Ophthalmol 122:71-5. 2011
    To assess the inter-session repeatability of the Goldmann-Weekers adaptometer for the measurement of cone dark adaptation in a population of healthy subjects. Data were obtained from 31 healthy adults (mean age 21.5 ± 2.5) on 2 days...
  54. ncbi Alterations of slow and fast rod ERG signals in patients with molecularly confirmed Stargardt disease type 1
    Hendrik P N Scholl
    Department of Pathophysiology of Vision and Neuroophthalmology, University Eye Hospital Tubingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 43:1248-56. 2002
    ..There is evidence that these slow and the fast rod ERG signals can be attributed to the rod bipolar-AII cell pathway and the rod-cone coupling pathway, respectively...
  55. ncbi Rod-mediated increment threshold functions in infants
    R M Hansen
    Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 41:4347-52. 2000
    ....
  56. pmc Rod sensitivity during Xenopus development
    Wei Hong Xiong
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Gen Physiol 120:817-27. 2002
    ..A similar delay in the maturity of chromophore regeneration may partially underlie the low sensitivity of rods observed in newborn mammals, including human infants...
  57. ncbi Dark adaptation during transient hyperglycemia in type 2 diabetes
    Stig Kraglund Holfort
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, 2600 Glostrup, Denmark
    Exp Eye Res 91:710-4. 2010
    It was the purpose of the present study to examine dark adaptation in subjects with type 2 diabetes during transient hyperglycemia...
  58. ncbi Circadian light sensitivity and rate of retinal dark adaptation in indoor and outdoor workers
    Marianne Rufiange
    J Biol Rhythms 22:454-7. 2007
  59. ncbi Effect of indocyanine green angiography using infrared fundus camera on subsequent dark adaptation and electroretinogram
    Feng Wen
    Laboratory of Ophthalmology, Ministry of Public Health of China, and Zhongshan Ophthalmic Center, Zhongshan Sun Yat Sen University, Guangzhou
    Doc Ophthalmol 105:51-6. 2002
    To observe the effect of indocyanine green angiography (ICGA) with infrared fundus camera on subsequent dark adaptation and the Ganzfeld electroretinogram (ERG), the ERGs of 38 eyes with different retinal diseases were recorded before ..
  60. ncbi The application of chromatic dark-adapted kinetic perimetry to retinal diseases
    Ygal Rotenstreich
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Ophthalmology 111:1222-7. 2004
    ..To demonstrate the value of a 2-color perimetric procedure for determining cone and rod system contributions to the dark-adapted kinetic visual field (VF)...
  61. ncbi The Scotopic Sensitivity Tester-1 and the detection of early age-related macular degeneration
    Gregory R Jackson
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 700 S 18th Street, Suite 609, Birmingham, AL 35294 0009, USA
    Ophthalmic Physiol Opt 26:431-7. 2006
    Previous research shows that dark adaptation is a marker of early age-related macular degeneration (ARMD), even when visual acuity remains good...
  62. ncbi Learning effect of dark adaptation among normal subjects
    John Christoforidis
    College of Medicine, The Ohio State University, Columbus, OH, USA
    Graefes Arch Clin Exp Ophthalmol 249:1345-52. 2011
    To examine and quantify any change in the dark adaptation (DA) function of normal subjects due to learning effect on test-retest.
  63. ncbi Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis
    G B Arden
    Dept of Optometry and Visual Science, City University, London, UK
    Vision Res 38:1723-9. 1998
    ..in diabetics with early retinopathy, but normal photopic vision, functional disturbance might appear in dark adaptation, since in such circumstances, (as shown by Linsenmeier and his colleagues) the already low retinal PO2 ..
  64. pmc Association between retinal thickness measured by spectral-domain optical coherence tomography (OCT) and rod-mediated dark adaptation in non-exudative age-related maculopathy
    Mark E Clark
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Br J Ophthalmol 95:1427-32. 2011
    To examine associations between retinal thickness and rod-mediated dark adaptation in older adults with non-exudative age-related maculopathy (ARM) or normal macular health.
  65. ncbi Dark adaptation pattern of pregnant women as an indicator of functional disturbance at acceptable serum vitamin A levels
    Y Wondmikun
    Department of Physiology, Gondar College of Medical Sciences, Gondar, Ethiopia
    Eur J Clin Nutr 56:462-6. 2002
    ..As a result of lack of precise guidelines, nutritional surveys on adults and high-risk groups are using diverse reference values as a dividing line between normal and deficient vitamin A status...
  66. ncbi Visual summation in night-flying sweat bees: a theoretical study
    Jamie Carroll Theobald
    Department of Cell and Organism Biology, Helgonavagen 3, Lund University, S 223 62, Lund, Sweden
    Vision Res 46:2298-309. 2006
    ..Improved reliability costs acuity, but dark adapted bees already suffer optical blurring, and summation further degrades vision only slightly...
  67. ncbi Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses
    A L Lyubarsky
    Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 20:2209-17. 2000
    ..Our observations argue that GRK1 is essential for normal deactivation of murine cone phototransduction and provide the first functional evidence for a major role of a specific GRK in the inactivation of vertebrate cone phototransduction...
  68. ncbi Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women
    Joanne M Graham
    Program in International Nutrition, Department of Nutritional Biology, University of California Davis, Davis, CA 95616, USA
    Am J Clin Nutr 85:1375-84. 2007
    ..Iron and riboflavin affect vitamin A utilization and photoreceptor function, respectively, and pilot data in the study population showed a high prevalence of iron and riboflavin deficiencies...
  69. ncbi Limits of colour vision in dim light
    Almut Kelber
    Department of Biology, Lund University, Helgonavagen 3, Lund, Sweden
    Ophthalmic Physiol Opt 30:454-9. 2010
    ..We review what is known about colour vision in dim light, and compare colour vision thresholds with the optical sensitivity of the photoreceptors in selected animal species with lens and compound eyes...
  70. pmc Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses
    Jerry E Johnson
    Department of Natural Sciences, University of Houston Downtown, Houston, TX, USA
    Mol Vis 13:887-919. 2007
    ..The goal of our structural and functional studies was to determine the spatiotemporal regulation of ATP and Ca2+ dynamics in rod spherules and cone pedicles...
  71. ncbi Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer
    Sherry L Ball
    Research Service, Cleveland VA Medical Center, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 43:1595-603. 2002
    ..The purpose of this study was to dentify which of the four beta subunits of VDCCs participates in the formation of this channel at the photoreceptor synapse and to determine how its absence affects visual processing...
  72. ncbi Glucose metabolism in the visual structures of rat monocularly deprived by eyelid suture after postnatal eye opening
    Wei Fang Wang
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 113 8591, Japan
    Jpn J Ophthalmol 49:6-11. 2005
    ..To determine the changes in the visual centers of rats following monocular visual deprivation after postnatal eyelid opening (PEO)...
  73. ncbi Noninvasive and simultaneous imaging of layer-specific retinal functional adaptation by manganese-enhanced MRI
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI 48201, USA
    Invest Ophthalmol Vis Sci 47:2668-74. 2006
    ....
  74. ncbi Fundus albipunctatus associated with compound heterozygous mutations in RPE65
    Patrik Schatz
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Ophthalmology 118:888-94. 2011
    ..To describe a family with an 18-year-old woman with fundus albipunctatus and compound heterozygous mutations in RPE65 whose unaffected parents and 1 female sibling harbored single heterozygous RPE65 mutations...
  75. pmc Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 50:2351-8. 2009
    ..To test the hypotheses that manganese-enhanced MRI (MEMRI) is useful in evaluating intraretinal ion dysregulation in wild-type (WT) and Cu/Zn superoxide dismutase (SOD1) overexpressor mice...
  76. pmc Quantitative mapping of ion channel regulation by visual cycle activity in rodent photoreceptors in vivo
    Bruce A Berkowitz
    Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 50:1880-5. 2009
    ..To test the hypothesis that the extent of outer retina uptake of manganese, measured noninvasively with manganese-enhanced MRI (MEMRI), is a quantitative biomarker of photoreceptor ion channel regulation by visual cycle activity...
  77. pmc Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors
    Akiko K Satoh
    Department of Biological Sciences, Graduate School of Science, Nagoya University, Nagoya 466 8601, Japan
    Neuron 67:997-1008. 2010
    ..Our results indicate that Arr2 translocation in Drosophila photoreceptors is driven by diffusion, but profoundly accelerated by phototransduction and Ca2+ influx...
  78. ncbi Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction
    Houbin Zhang
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, USA
    Mol Vis 9:231-7. 2003
    ..The underlying translocation mechanisms are unclear. This study examines these previously demonstrated translocation in mice with defective phototransduction...
  79. ncbi A Ni(2+)-sensitive component of the ERG b-wave from the isolated bovine retina is related to E-type voltage-gated Ca(2+) channels
    Matthias Lüke
    Institute of Neurophysiology, University of Cologne, Robert Koch Str 39, 50931 Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 243:933-41. 2005
    ..During retinal signal perception and processing, presynaptic Ca(2+) channels facilitate neurotransmitter release in photoreceptors and bipolar neurons, at nonspiking synapses which generate graded potentials...
  80. ncbi Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy
    Hendrik P N Scholl
    Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:574-83. 2004
    ..To investigate photopic and scotopic sensitivity of retinal areas that show increased fundus autofluorescence (FAF) in patients with age-related maculopathy (ARM)...
  81. ncbi Nonlinear signal transfer from mouse rods to bipolar cells and implications for visual sensitivity
    Greg D Field
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle 98195, USA
    Neuron 34:773-85. 2002
    ..As a consequence, rod bipolars provide a near-optimal readout of rod signals at light levels near visual threshold...
  82. pmc Rod and cone contributions to the a-wave of the electroretinogram of the macaque
    John G Robson
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    J Physiol 547:509-30. 2003
    ..In conclusion, postreceptoral components must be taken into account when interpreting the leading edge of the rod- and cone-driven a-waves of the dark-adapted ERG...
  83. ncbi Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications
    Guy A Perkins
    Department of Neurosciences and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, USA
    Mol Vis 9:60-73. 2003
    ..Therefore, we investigated the oxidative metabolism and three-dimensional membrane architecture of mouse rod and cone inner segment mitochondria...
  84. ncbi The retina of c-fos-/- mice: electrophysiologic, morphologic and biochemical aspects
    N Kueng-Hitz
    Department of Ophthalmology, University Hospital Zurich, Switzerland
    Invest Ophthalmol Vis Sci 41:909-16. 2000
    ..To analyze the consequences of the absence of c-fos in the retina, we investigated whether the retinas of c-fos-/- mice have a reduced capacity to absorb and transduce light compared with c-fos+/+ mice...
  85. ncbi Electroretinography of wild-type and Cry mutant mice reveals circadian tuning of photopic and mesopic retinal responses
    Morven A Cameron
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester, UK
    J Biol Rhythms 23:489-501. 2008
    ..These data suggest that circadian clocks drive a fundamental fine-tuning of retinal pathways that is particularly apparent under conditions in which vision relies upon either cones alone or mixed rod + cone photoreception...
  86. pmc Light adaptation and dark adaptation of human rod photoreceptors measured from the a-wave of the electroretinogram
    M M Thomas
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 518:479-96. 1999
    ..Similar behaviour has previously been seen in psychophysical dark adaptation experiments, for the dependence of the 'second component' of recovery on the level of bleaching.
  87. pmc Occupancy of the chromophore binding site of opsin activates visual transduction in rod photoreceptors
    V J Kefalov
    Department of Physiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Gen Physiol 113:491-503. 1999
    ..We propose that this distinction is due to a fundamental difference in the interaction of rod and cone opsins with retinal, which may have implications for the different physiology of the two types of photoreceptors...
  88. ncbi Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lecture
    Trevor D Lamb
    Division of Neuroscience, John Curtin School of Medical Research, and ARC Centre of Excellence in Vision Science, The Australian National University, Canberra, Australia
    Invest Ophthalmol Vis Sci 47:5137-52. 2006
  89. ncbi Molecular basis of dark adaptation in rod photoreceptors
    C S Leibrock
    Department of Physiology, University of Cambridge, UK
    Eye (Lond) 12:511-20. 1998
    ..This product activates transduction with an efficacy about 100 times greater than that of opsin...
  90. ncbi Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation
    Vadim Y Arshavsky
    Dept of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Trends Neurosci 25:124-6. 2002
    ....
  91. ncbi Two realms of dark adaptation
    M L Firsov
    Institute for Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 Thorez Prospect, 194223 St Petersburg, Russia
    Vision Res 45:147-51. 2005
    ..The transition between the two regimes of adaptation is rather abrupt, occurring within a few-fold range of stimulus intensity. This marks the border between reversal of light adaptation and dark adaptation, as it is commonly defined.
  92. pmc Extremely rapid recovery of human cone circulating current at the extinction of bleaching exposures
    J S Kenkre
    Division of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia
    J Physiol 567:95-112. 2005
    ....
  93. ncbi Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation
    J C Saari
    Department of Ophthalmology, Box 356485, University of Washington, Seattle, WA 98195, USA
    Neuron 29:739-48. 2001
    Mutations in the human CRALBP gene cause retinal pathology and delayed dark adaptation. Biochemical studies have not identified the primary physiological function of CRALBP...
  94. ncbi Responses of suprachiasmatic nucleus neurons to light and dark adaptation: relative contributions of melanopsin and rod-cone inputs
    Elise Drouyer
    INSERM, U846, F 69500 Bron, France
    J Neurosci 27:9623-31. 2007
    ....
  95. ncbi Role of noncovalent binding of 11-cis-retinal to opsin in dark adaptation of rod and cone photoreceptors
    V J Kefalov
    Department of Physiology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neuron 29:749-55. 2001
    ..Here, we show that the noncovalent interaction between 11-cis-retinal and opsin affects the rate of dark adaptation. In rods, 11-cis-retinal produces a transient activation of the phototransduction cascade that precedes ..
  96. ncbi Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina
    J K McBee
    Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
    Prog Retin Eye Res 20:469-529. 2001
    ..The aim of this review is to summarize recent developments in our current understanding of the retinoid cycle at the molecular level, and to examine the relevance of these reactions to phototransduction...
  97. ncbi Dark-adapted rod suppression of cone flicker detection: Evaluation of receptoral and postreceptoral interactions
    Dingcai Cao
    Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois 60637, USA
    Vis Neurosci 23:531-7. 2006
    ..Measurements were made either with adaptation to the stimulus field after dark adaptation or during a brief period following light adaptation...
  98. ncbi Transducin activation state controls its light-dependent translocation in rod photoreceptors
    Vasily Kerov
    Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:41069-76. 2005
    ..inner segments (IS) and synaptic terminals (ST) is recognized as a critical contributing factor to light and dark adaptation. The mechanisms of light-induced transducin translocation to the IS/ST and its return to the OS during dark ..
  99. ncbi Dark adaptation and the retinoid cycle of vision
    T D Lamb
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Prog Retin Eye Res 23:307-80. 2004
    ..The slowness of this phenomenon of "dark adaptation" has been studied for many decades, yet is still not fully understood...
  100. ncbi Effects of prolonged dark adaptation in patients with retinitis pigmentosa of Bothnia type: an electrophysiological study
    Marie S I Burstedt
    Department of Clinical Sciences Ophthalmology, University of Umea, 901 85, Umea, Sweden
    Doc Ophthalmol 116:193-205. 2008
    ..the capacity of recovery of the whole retinal area and different cell types induced by extremely prolonged dark adaptation (DA) in BD disease and to gain further understanding of the pathogenesis of BD...
  101. pmc Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion
    Jacque L Duncan
    Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    J Neurosci 26:7201-11. 2006
    ..These results suggest that PMCA2-mediated Ca2+ extrusion modulates the amplitude and timing of the high-sensitivity rod pathway to a much greater extent than that of the cone pathway...

Research Grants62

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration Number: 11-EI-0147 Summary: Background: - Age-related ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration Number: 11-EI-0147 Summary: Background: - Age-related ..
  3. VitaminA and Sickle Cell Disease:Improving Suboptimal Status with Supplementation
    KELLY ANN DOUGHERTY; Fiscal Year: 2013
    ..for healthy children failed to improve vit A status, resulting in no change in hospitalizations, growth or dark adaptation. This indicates an increased vit A requirement most likely due to chronic inflammation, low vit A intake and ..
  4. Circadian Clock Function in the Mammalian Retina
    Christophe P Ribelayga; Fiscal Year: 2013
    ..By interacting with the dopamine and melatonin neuromodulator systems that are involved in light/dark adaptation, the retinal clock provides a mechanism to anticipate the change in light intensity that occurs at dawn and ..
  5. Aging and ARM: Dark Adaptation Impairment
    Cynthia Owsley; Fiscal Year: 2012
    ..Previous research indicates that rod-mediated dark adaptation may be an alternative outcome for consideration, for several reasons...
  6. Molecular Mechanism of Vitamin A Uptake for Vision
    Hui Sun; Fiscal Year: 2011
    ..In humans, loss of RBP function impairs dark adaptation, and causes progressive atrophy of the retinal pigment epithelium (RPE) in the eye at young ages...
  7. Genetics and Therapy of Age-related Retinal Dysfunction in A/J Mice
    Tadao Maeda; Fiscal Year: 2013
    ..Based on experiments in mice, age-related deterioration of dark adaptation is ameliorated by artificial cis-retinoid treatment...
  8. SPECTRAL AND METABOLIC BASIS OF VISUAL RESPONSES
    M Carter Cornwall; Fiscal Year: 2013
    ..relationship between pigment regeneration and the recovery of sensitivity following exposure to bright light (dark adaptation) is presently poorly understood...
  9. Transport processes in photoreceptors
    Yiannis Koutalos; Fiscal Year: 2012
    ..in all-trans retinal removal have been implicated in a variety of retinal diseases, ranging from impaired dark adaptation to complete blindness...
  10. Clinical trials of gene therapy for Leber congenital amaurosis
    SAMUEL GREGORY JACOBSON; Fiscal Year: 2013
    ..retinal location, pre-treatment visual function and the extent of improvement post-treatment;and c) if the dark adaptation defect changes with time after treatment...
  11. MECHANISMS OF ADAPTATION IN MAMMALIAN CONES
    VLADIMIR JIVKOV KEFALOV; Fiscal Year: 2013
    ..Specifically, we will determine the ability of mammalian retina to promote pigment regeneration and dark adaptation in cones independently of the pigment epithelium...
  12. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2012
    ..monocular lid suture preceded by a previous monocular deprivation (MD), or monocular lid suture preceded by dark adaptation. For comparison, we will also apply two additional manipulations, binocular deprivation (BD) and monocular ..
  13. Dark adaptation and hypoxia in diabetic retinopathy
    Eric A Newman; Fiscal Year: 2013
    ..The progression of retinopathy will be assessed at 0.5, 3, 6, and 12 months following induction of diabetes. ..
  14. Metabolic Modulation of Vision
    Robert Barlow; Fiscal Year: 2009
    ..In the case of P226, we will explore the preliminary hypothesis that its dark adaptation-dependent PDA phenotype is related to metarhodopsin deactivation by extensive, multiple phosphorylation...
  15. Phototransduction in dark adaptation and retinal degeneration
    Jeannie Chen; Fiscal Year: 2013
    ..The first aim will investigate biochemical cascades in rods following bright light exposure that may slow dark adaptation. The second aim is to investigate the induction of endoplasmic stress by bright light exposure and mis-folded ..
  16. RESCUE OF RETINAL DEGENERATION BY GENE THERAPY
    MICHAEL SUBER; Fiscal Year: 1999
    ..Clinically, this disorder produces severe visual loss; abnormal rod and cone electroretinograms, poor dark adaptation thresholds, and intraretinal pigmentation in the mid-periphery signaling the degeneration of retinal tissue...
  17. ELECTROPHYSIOLOGICAL STUDIES OF RETINAL DEGENERATIONS
    Eliot Berson; Fiscal Year: 2002
    ..Risk factor analyses of patients with the same mutation may reveal non-hereditable factors (e.g., dietary factors) associated with a more or less severe rate of degeneration, with possible implications for therapy. ..
  18. PHYSIOLOGY OF PHOTORECEPTORS
    GORDON FAIN; Fiscal Year: 1999
    ..to use microelectrode recording, external perfusion, and microspectrophotometry to elucidate the mechanism of dark adaptation in vertebrate rods and cones...
  19. Dietary Fatty Acids and Photoreceptor Function
    Martha Neuringer; Fiscal Year: 2003
    ..flash intensities; (2) the desensitization of rod responses by background light; and (3) the time-course of dark adaptation over a range of bleaches...
  20. SYSTEM ANALYSIS OF PHYCOMYCES PHOTORESPONSES
    EDWARD LIPSON; Fiscal Year: 1993
    ..The recently discovered dependence of dark adaptation on dim, subliminal light will be pursued to help establish which photoreceptor mediates this effect, which is ..
  21. AdaptRx: Surrogate Marker for Vision Loss in AMD
    John Edwards; Fiscal Year: 2009
    ..proposes to develop a new clinical trial endpoint for age-related macular degeneration (AMD) based on dark adaptation. A major challenge in attacking AMD is the lack of adequate clinical trial endpoints...
  22. METABOTROPIC GLUTAMATE RECEPTORS ON AMACRINE CELLS
    Evanna Gleason; Fiscal Year: 2002
    ..One type of modulation that is fairly well understood is light-dark adaptation but the preponderance of modulatory substances in the retina suggests that other types of adaptation also ..
  23. DOPAMINE AND RETINAL ADAPTATION
    Paul Witkovsky; Fiscal Year: 2001
    ..research is to investigate the cellular and synaptic mechanisms underlying the processes of light and dark adaptation. The major tenet is that the hard wiring anatomically defines the physical synapses, but synaptic efficacy is ..
  24. PROPERTIES OF LIGHT MODULATED ION CHANNELS IN THE RETINA
    ANITA ZIMMERMAN; Fiscal Year: 2005
    ..in two ways: 1) it may be involved in some aspect of normal visual transduction, such as in light or dark adaptation; and 2) its pharmacologic or genetic manipulation may be useful in treating some forms of retinal ..
  25. HUMAN RETINAL PHOTOPIGMENT CHANGES DUE TO AGING
    HOWARD BAKER; Fiscal Year: 1990
    ..Densitometric measurements have been found to be affected by the size of the pupil, however, and that relationship is explored in preliminary experiments...
  26. CA 2+ ELECTRODE MEASUREMENTS IN LIMULUS PHOTORECEPTORS
    Jeffrey Owen; Fiscal Year: 1980
    ..By accurately knowing the concentration of Ca, it will aid toward developing a light-adaptation mechanism which will yield insight into the basis of the photoresponse. ..
  27. VISUAL ADAPTATION IN THE VERTEBRATE RETINA
    Harris Ripps; Fiscal Year: 2005
    ....
  28. Electrical Synapses of Horizontal Cells
    Dao Qi Zhang; Fiscal Year: 2007
    ..greatly advance our understanding of the function and plasticity of retinal neuronal networks during light/dark adaptation and our understanding of retinal functional modification during photoreceptor degeneration...
  29. THE VISUALLY DEFECTIVE PHENOTYPE OF RBP-DEFICIENT MICE
    WILLIAM BLANER; Fiscal Year: 2002
    ..due to heterozygous mutations in the RBP gene were found to have only mildly defective vision (reduced dark adaptation and slightly reduced acuity), but not blindness, in the face of serum RBP levels below the detection limits ..
  30. CLINICAL ELECTROPHYSIOLOGY OF HUMAN CONE MECHANISMS
    Peter Gouras; Fiscal Year: 1992
    ..During the course of this grant the range over which we can examine light and dark adaptation will be expanded by increasing the full field adapting light by a factor of four, from 15,000 to 60,000 ..
  31. Diagnostic for Age-Related Macular Degeneration
    John Edwards; Fiscal Year: 2005
    ..It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work ..
  32. Regulation of light sensitivity by phosducin & 14-3-3
    MARK BITENSKY; Fiscal Year: 2004
    ..is to contribute new information that will strengthen understanding of' the critical process of light and dark adaptation in the visual system especially in the context of specific new findings on the light regulation of rod ..
  33. Neuromodulators and Signaling Cascades in Retina
    P Iuvone; Fiscal Year: 2007
    ..expression of Ca 2+ / calmodulin-stimulated adenylyl cyclase(s) leads to the abnormalities of light and dark adaptation seen in dopamine D4 receptor deficient mice...
  34. Conference--The Biology and Chemistry of Vision
    Wolfgang Baehr; Fiscal Year: 2003
    ..is designed to focus primarily on photoreceptor cell components involved in development, visual transduction, dark adaptation, and cell maintenance...
  35. MECHANISMS OF VISUAL SENSITIVITY
    JOSEPH STURR; Fiscal Year: 1980
    ..project are to study the mechanisms underlying the changes in visual sensitivity during light adaptation and dark adaptation. Specifically, we plan to examine in psychophysical experiments whether and under what conditions the rod and ..
  36. MECHANISMS OF VISUAL SENSITIVITY
    JOSEPH STURR; Fiscal Year: 1990
    ..project are to study the mechanisms underlying the changes in visual sensitivity during light adaptation and dark adaptation. Specifically, we plan to examine in psychophysical experiments whether and under what conditions the rod and ..
  37. Conference Proposal: The Biology and Chemistry of Vision
    M Cornwall; Fiscal Year: 2005
    ..is designed to focus primarily on photoreceptor cell components involved in development, visual transduction, dark adaptation, and cell maintenance...
  38. FUNCTIONAL ORGANIZATION OF THE RETINA
    JOHN MC REYNOLDS; Fiscal Year: 2002
    ..to our understanding of visual information processing in the retina and how the synaptic pathways are modulated during light and dark adaptation to optimize the output of retinal ganglion cells for differing visual conditions.
  39. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
    ..The results of this research will lead to the formulation of hypotheses about the underlying molecular events in these diseases and may evolve into recommendations for treatment paradigms in these blinding retinal degenerations. ..
  40. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
    ....
  41. Circadian Rhythms: Photic Sensitivity and Behavior
    Roberto Refinetti; Fiscal Year: 2003
    ..The research project will investigate a sensory mechanism ("dark adaptation") of great importance for the understanding of the process by which circadian rhythms are synchronized by the ..
  42. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  43. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  44. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..have validated that known retinal layer-specific changes in neuronal function / ion demand during light and dark adaptation can be robustly measured by high resolution MEMRI following systemic administration of a non-toxic amount of ..
  45. COMPUTATIONAL ANALYSIS OF CONE PHOTOTRANSDUCTION
    RUSSELL HAMER; Fiscal Year: 2005
    ..Similarly, such models allow one to conceptualize and test, noninvasively, putative mechanisms underlying retinal diseases affecting photoreceptor function, and also to identify receptoral immaturities in developing visual systems. ..
  46. RETINAL PATHOPHYSIOLOGY OF INFANTS AND ADULTS
    David Birch; Fiscal Year: 2005
    ..specific defects in activation and inactivation stages of rod phototransduction, rod light adaptation and rod dark adaptation. Through a subcontract with Dr...
  47. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 2003
    ..In addition, the time course of the appearance of cytoplasmic cytochrome C and the activation of cellular caspases will be determined by antibody-based techniques, immunocytochemistry and enzymatic analysis. ..
  48. Clinical Vision Research Unit at UAB
    Cynthia Owsley; Fiscal Year: 2006
    ..Furthermore, UAB has already established many community relations and research infrastructure contacts with these subpopulations that will immediately facilitate our research efforts. ..
  49. Low-Level Prenatal Lead Exposure and Retinal Toxicity
    Donald Fox; Fiscal Year: 2009
    ....
  50. Planning a Clinical Trial on Low Vision Rehabilitation
    Cynthia Owsley; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Reading Enhancement for Patients with Visual Field Loss
    MICHAEL SANDBERG; Fiscal Year: 2004
    ....
  52. CaBP4, a Photoreceptor Specific Calcium-Binding Protein
    Francoise Haeseleer; Fiscal Year: 2005
    ..The mechanism of interaction of CaBP4 with its target will also be examined using both in vitro and in vivo procedures. ..
  53. mRNA expression by RPE cells in myopia
    Richard Stone; Fiscal Year: 2006
    ..We believe this program will lead to improved understanding of the etiology of refractive errors and ultimately to effective approaches to arrest myopia in children. ..
  54. PSYCHOPHYSICAL STUDIES OF COLOR DEFECTIVE VISION
    Joel Pokorny; Fiscal Year: 2006
    ....
  55. Gene Therapy of Autosomal Recessive RP
    Simon Petersen Jones; Fiscal Year: 2006
    ..abstract_text> ..
  56. Retcam 120 Wide Field Digital Imaging System
    Anne Fulton; Fiscal Year: 2002
    ..The minor users will take advantage of the wide field images as well as the highly magnified views of the macula and optic nerve head (optic disc), including the fluorescein capability. ..
  57. Melanopsin-based form vision in photoreceptor disease
    MICHAEL SANDBERG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. A System for Study of Pediatric Visual Pathways
    Anne Fulton; Fiscal Year: 2004
    ..With these studies as a whole, we expect to obtain new knowledge about the processes that govern vision and its development in these pediatric disorders. ..
  59. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    ..It facilitates dark adaptation and likely coordinates other diumal events that occur in the retina such as photoreceptor outer segment disc ..
  60. Molecular Characterization of Chick Retina during Refractive Development
    RICHARD ALAN STONE; Fiscal Year: 2010
    ....
  61. PLASTICITY OF MAMMALIAN CIRCADIAN AXIS
    Gianluca Tosini; Fiscal Year: 2003
    ..abstract_text> ..
  62. Caloric Restriction and Aging in Eyes
    Peter Gouras; Fiscal Year: 2010
    ..Because many of these primates are near the end of their lifespan, there is an element of urgency in our goal to correlate noninvasive clinical testing prior with post mortem histology. ..