Genomes and Genes
Summary: The adjustment of the eye to variations in the intensity of light. Light adaptation is the adjustment of the eye when the light threshold is increased; DARK ADAPTATION when the light is greatly reduced. (From Cline et al., Dictionary of Visual Science, 4th ed)
Publications189 found, 100 shown here
- Adaptation in vertebrate photoreceptorsG L Fain
Department of Physiological Science, University of California, Los Angeles, California 90095 1527, USA
Physiol Rev 81:117-151. 2001..The resulting decrease in intracellular Ca(2+) then modulates the transduction cascade, by a mechanism very similar to the one responsible for altering sensitivity during background adaptation...
- Light adaptation in salamander L-cone photoreceptorsFrederick S Soo
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
J Neurosci 28:1331-42. 2008....
- Cone-based vision of rats for ultraviolet and visible lightsG H Jacobs
Neuroscience Research Institute and Department of Psychology, University of California, Santa Barbara 93106, USA
J Exp Biol 204:2439-46. 2001..Evidence of dichromatic color vision in the rat was subsequently obtained from tests of wavelength discrimination...
- The circadian clock in the retina controls rod-cone couplingChristophe Ribelayga
Department of Neuroscience, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Neuron 59:790-801. 2008..The increase in the strength and extent of rod-cone coupling at night may facilitate the detection of large dim objects...
- Toward a unified model of vertebrate rod phototransductionR D Hamer
Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
Vis Neurosci 22:417-36. 2005..Informative limitations of the model are also discussed...
- Two temporal phases of light adaptation in retinal rodsPeter D Calvert
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Gen Physiol 119:129-45. 2002..Other possible mechanisms are discussed...
- Light adaptation of cone photoresponses studied at the photoreceptor and ganglion cell levels in the frog retinaK Donner
Department of Biosciences, University of Helsinki, Finland
Vision Res 38:19-36. 1998....
- Transducin translocation in rods is triggered by saturation of the GTPase-activating complexEkaterina S Lobanova
Albert Eye Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 27:1151-60. 2007....
- Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouseMaxim Sokolov
Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Biol Chem 279:19149-56. 2004..This increased solubility of transducin would make it more susceptible to translocation from the outer segments...
- Long-term renormalization of chromatic mechanisms following cataract surgeryPeter B Delahunt
Department of Ophthalmology and Section of Neurobiology, Physiology and Behavior, University of California Davis, 95817, USA
Vis Neurosci 21:301-7. 2004..The shifts in the achromatic point occur over a number of months and appear to occur independently of the fellow eye...
- Molecular mechanisms of vertebrate photoreceptor light adaptationE N Pugh
FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, Institute of Neurological Sciences, Stellar Chance Laboratories, University of Pennsylvania, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104 6069, USA
Curr Opin Neurobiol 9:410-8. 1999..Quantitative analysis of these mechanisms is providing new insights into the nature of rod photoreceptor light adaptation...
- Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivoTom S Kim
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Biol Chem 280:8694-704. 2005....
- Human cone photoreceptor responses measured by the electroretinogram [correction of electoretinogram] a-wave during and after exposure to intense illuminationA A Paupoo
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 529:469-82. 2000..5 min after a near-total bleach. This time course is very similar to previous measurements of the regeneration of cone photopigment, and it seems highly probable that the reduction in dim-flash sensitivity results from pigment depletion...
- Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish conesMatthew J Kennedy
Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195, USA
Neuron 41:915-28. 2004..Immunocytochemical analyses revealed that neither light nor cytoplasmic Ca2+ influences the localization of transducin in zebrafish cones...
- High cGMP synthetic activity in carp conesNorihiko Takemoto
Graduate School of Frontier Biosciences, Graduate School of Science, Osaka University, Suita, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 106:11788-93. 2009..Our estimation of the in situ GC activity reasonably explained the rapid recovery and nonsaturating behavior of cone light responses...
- The limit of photoreceptor sensitivity: molecular mechanisms of dark noise in retinal conesDavid Holcman
Keck Center for Theoretical Neurobiology and Department of Physiology, School of Medicine, University of California at San Francisco, 94143, USA
J Gen Physiol 125:641-60. 2005..Both these features make cones less light sensitive than rods...
- Phototransduction in primate cones and blowfly photoreceptors: different mechanisms, different algorithms, similar responseJ H van Hateren
Department of Neurobiophysics, University of Groningen, Nijenborgh 4, NL 9747 AG, Groningen, The Netherlands
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:187-97. 2006..A direct comparison of the responses to a natural time series of intensities, simulated in the cone and measured in the blowfly photoreceptor, shows that the responses are quite similar...
- Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptorsMichael L Woodruff
Department of Physiological Science, University of California Los Angeles, Los Angeles, California 90095 1606, USA
J Neurosci 28:2064-74. 2008..Our experiments provide evidence for modulation of GAP protein-dependent response turnoff, which may also play a role in controlling signal duration at hormone receptors and synapses in the CNS...
- Long-term light adaptation in photoreceptors of the housefly, Musca domesticaB G Burton
Department of Zoology, University of Cambridge, Cambridge, UK
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 188:527-38. 2002..It is also found that the impedance amplitude of the photoreceptor increases during long-term adaptation, suggesting that the area of the photoreceptor's membrane is reduced...
- Two realms of dark adaptationM L Firsov
Institute for Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 Thorez Prospect, 194223 St Petersburg, Russia
Vision Res 45:147-51. 2005..The transition between the two regimes of adaptation is rather abrupt, occurring within a few-fold range of stimulus intensity. This marks the border between reversal of light adaptation and dark adaptation, as it is commonly defined...
- Guidelines for basic multifocal electroretinography (mfERG)Michael F Marmor
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA
Doc Ophthalmol 106:105-15. 2003
- Fast and slow contrast adaptation in retinal circuitryStephen A Baccus
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Neuron 36:909-19. 2002..Slow adaptation did not affect kinetics, but produced a gradual hyperpolarization. This hyperpolarization can account for slow adaptation in the spiking output of ganglion cells...
- Vertebrate photoreceptorsT Ebrey
University of Washington, Seattle 98195, USA
Prog Retin Eye Res 20:49-94. 2001....
- The roles of trp and calcium in regulating photoreceptor function in DrosophilaB Minke
Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Curr Opin Neurobiol 6:459-66. 1996..Furthermore, trp is an archetypal member of a multigene family whose products share a structure that is highly conserved throughout evolution, from worms to humans...
- Oxygen consumption in the rat outer and inner retina: light- and pharmacologically-induced inhibitionC J Medrano
College of Optometry, University of Houston, Texas 77204 6052, USA
Exp Eye Res 61:273-84. 1995..abstract truncated at 400 words)..
- Light adaptation and dark adaptation of human rod photoreceptors measured from the a-wave of the electroretinogramM M Thomas
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 518:479-96. 1999..Similar behaviour has previously been seen in psychophysical dark adaptation experiments, for the dependence of the 'second component' of recovery on the level of bleaching...
- Prolonged photoresponses in transgenic mouse rods lacking arrestinJ Xu
Division of Biology, California Institute of Technology, Pasadena 91125, USA
Nature 389:505-9. 1997..The intensity dependence of the photoresponse in rods lacking arrestin further suggests that, although arrestin is required for normal signal termination, it does not participate directly in light adaptation...
- Light adaptation and sensitivity controlling mechanisms in vertebrate photoreceptorsI Perlman
Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Prog Retin Eye Res 17:523-63. 1998..Therefore, cones do not exhibit saturation even when the level of ambient illumination is raised by 6-7 log units...
- Compensation for light loss resulting from filtering by macular pigment: relation to the S-cone pathwayJames M Stringham
Vision Science Laboratory, University of Georgia, Athens, Georgia, USA
Optom Vis Sci 83:887-94. 2006..This study characterizes compensation for different densities of MP...
- Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptationMaxim Sokolov
Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
Neuron 34:95-106. 2002....
- Tetrachromacy, oil droplets and bird plumage coloursM Vorobyev
Schenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, St Petersburg, Russia
J Comp Physiol A 183:621-33. 1998....
- Unveiling the foveal blue scotoma through an afterimageSvein Magnussen
Brain Research Unit, University of Freiburg, Hansastrasse 9, D 79104 Freiburg, Germany
Vision Res 44:377-83. 2004..The results support the hypothesis of an active post-receptoral process for filling-in of chromatic scotomas...
- Adaptation and perceptual norms in color visionMichael A Webster
Department of Physchology, University of Nevada, Reno, Nevada 89557, USA
J Opt Soc Am A Opt Image Sci Vis 25:2817-25. 2008..These results suggest a close link between the norms for appearance and coding in color vision and illustrate a general paradigm for exploring this link in other perceptual domains...
- Color appearance changes resulting from iso-luminant chromatic adaptationS M Wuerger
Center for Neural Science, New York University, New York, USA
Vision Res 36:3107-18. 1996....
- Transducin activation state controls its light-dependent translocation in rod photoreceptorsVasily Kerov
Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 280:41069-76. 2005..Thus, the light-dependent translocations of transducin are controlled by the GTP-hydrolysis on Gtalpha, and apparently, do not require Gtalpha interaction with RGS9 and PDE6...
- Human cone light adaptation: from behavioral measurements to molecular mechanismsAndrew Stockman
Institute of Ophthalmology, University College London, London, UK
J Vis 6:1194-213. 2006..Together, these mechanisms act to maintain the cone visual system in an optimal operating range and to protect it from overload...
- Information theoretical evaluation of parametric models of gain control in blowfly photoreceptor cellsJ H van Hateren
Department of Neurobiophysics, University of Groningen, Nijenborgh 4, NL 9747 AG Groningen, The Netherlands
Vision Res 41:1851-65. 2001..Any remaining peaks that would drive the photoreceptor out of its dynamic range are handled by the final compressive nonlinearity...
- Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptationP D Calvert
Howe Laboratory of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Gen Physiol 111:39-51. 1998..Therefore, cGMP-dependent regulation of transducin GTPase is likely to occur only during prolonged bright illumination...
- Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatusH Yamamoto
Berman Gund Laboratory for the Study of Retinal Degenerations and the Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, USA
Nat Genet 22:188-91. 1999..Our results suggest that mutant alleles in RDH5 are a cause of fundus albipunctatus, a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments...
- Computational analysis of vertebrate phototransduction: combined quantitative and qualitative modeling of dark- and light-adapted responses in amphibian rodsR D Hamer
Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
Vis Neurosci 17:679-99. 2000..The present research illustrates the importance of a hybrid qualitative/quantitative approach to model development, and the limitations of modeling restricted sets of data...
- Recovery of the rod photoresponse in infant ratsAnne B Fulton
Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Vision Res 43:3081-5. 2003..The kinetics of rod cell recovery are likely the same in infants and adults...
- Luminosity--a perceptual "feature" of light-emitting objects?Alessia Correani
Department of Experimental Psychology, Bristol University, Bristol BS8 1TN, UK
Vision Res 46:3915-25. 2006..This implies that luminance gradients (not object luminosity) are encoded as features, questioning the existence of specific sensory mechanisms to detect light-emitting objects...
- Induction effects for heterochromatic brightness matching, heterochromatic flicker photometry, and minimally distinct border: implications for the neural mechanisms underlying inductionKaren L Gunther
Department of Neuroscience, Oberlin College, Ohio 44074, USA
J Opt Soc Am A Opt Image Sci Vis 22:2182-96. 2005..These results are discussed in terms of which underlying color pathways (L+ M versus L-M) may contribute to induction effects for the different tasks...
- A comparison of ERG abnormalities in XLRS and XLCSNBKeith Bradshaw
Ophthalmology Department, Addenbrookes Hospital, Cambridge, UK
Doc Ophthalmol 108:135-45. 2004..The ERG results suggest that the RS1 and CACNA1F gene products have comparable functional consequences and that all three genes may affect multiple retinal sites...
- Cone opponency in the near peripheral retinaI J Murray
Faculty of Life Sciences, University of Manchester, United Kingdom
Vis Neurosci 23:503-7. 2006..The data suggest that the S-L+M channel is more robust to increasing eccentricity than the L-M channel. Observations are interpreted in terms of the known underlying morphological and physiological differences in these channels...
- Influence of photic environment on the form of the fish electroretinographic off-responseZoran Gacic
Center for Multidisciplinary Studies, University of Belgrade, Serbia and Montenegro
Ann N Y Acad Sci 1048:437-40. 2005..On the other hand, dark-adapted electroretinograms of two perch-like species, perch (Perca fluviatilis) and painted comber (Serranus scriba), exhibited a positive off-wave, exceeding the b-wave amplitude under bright photopic conditions...
- An in vivo microdialysis study of light/dark-modulation of vitreal dopamine release in zebrafishDinesh Puppala
Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
J Neurocytol 33:193-201. 2004..When using steady light, none of these effects were seen. Our study also demonstrates that in vivo microdialysis can successfully be applied to the investigation of retinal DA release in zebrafish...
- A neuromorphic model for achromatic and chromatic surface representation of natural imagesSimon Hong
Department of Cognitive and Neural Systems, Center for Adaptive Systems, Boston University, 677 Beacon Street, Boston, MA 02215, USA
Neural Netw 17:787-808. 2004..The model is also able to process natural color images under variable lighting conditions, and is compared with the popular RETINEX model...
- Colour matching of isoluminant samples and backgrounds: a dimming effectIan J Murray
Faculty of Life Sciences, Department of Optometry and Neuroscience, UMIST, PO Box 88, Manchester M60 1QD, UK
Perception 34:927-32. 2005..Details of analysis in cone-opponent space (L - M, L + M - S, L + M) are presented in the companion paper (Stanikunas et al, 2005 Perception 34 this issue)...
- Do common mechanisms of adaptation mediate color discrimination and appearance? Uniform backgroundsJames M Hillis
University of Pennsylvania, Department of Psychology, Philadelphia 19104, USA
J Opt Soc Am A Opt Image Sci Vis 22:2090-106. 2005..This result suggests that effects of the contexts we studied on color appearance and discriminability are controlled by the same underlying mechanism...
- Integration of differing chromaticities in early and midlevel spatial visionJ Anthony Wilson
Department of Psychology, University of California at Berkeley, California 94720, USA
J Opt Soc Am A Opt Image Sci Vis 22:2169-81. 2005..The results are compared with those obtained for contrast variation in luminance-defined Glass Patterns and are discussed in terms of current multistage models of color processing by the visual system...
- Colour-luminance interactions in binocular summationJose M Medina
McGill Vision Research, Department of Ophthalmology, McGill University, Montreal, Quebec, Canada H3A 1A1
Vision Res 47:1120-8. 2007..Our results suggest the existence of binocular colour-luminance interactions restricted to high temporal frequencies...
- Photopic vision in eels: evidences of color discriminationIlija Damjanović
Institute for Problems of Information Transmission, Academy of Sciences, Moscow, Russia
Ann N Y Acad Sci 1048:69-84. 2005..The existence of green-sensitive and blue-sensitive cone units was thus revealed by both electrophysiological and microspectrophotometric techniques...
- Chromatic and contrast selectivity in color contrast adaptationYoko Mizokami
Department of Psychology, University of Nevada, Reno 89557, USA
Vis Neurosci 21:359-63. 2004..Such variations in contrast sensitivity are also consistent with physiological recordings of cortical neurons...
- Neural adjustments to chromatic blurMichael A Webster
Department of Psychology, University of Nevada, Reno, Nevada 89557, USA
Spat Vis 19:111-32. 2006....
- Recovery of rod-mediated a-wave during light-adaptation in mGluR6-deficient miceYoshiki Ueda
Department of Ophthalmology, Nagahama City Hospital, Oh Inuicho, Nagahama, Shiga, Japan
Vision Res 46:1655-64. 2006..The light-adapted b-wave of WT mice showed no corresponding recovery. We conclude that rod contribution must be considered in the analyses of the light-adapted a-waves of KO mice...
- Identification of contrast-defined letters benefits from perceptual learning in adults with amblyopiaSusana T L Chung
College of Optometry and Center for Neuro Engineering and Cognitive Science, University of Houston, Houston, TX, USA
Vision Res 46:3853-61. 2006....
- Microsaccade directions do not predict directionality of illusory brightness changes of overlapping transparent surfacesP U Tse
Department of Psychological and Brain Sciences, Moore Hall, Dartmouth College, Hanover, NH 03755, USA
Vision Res 46:3823-30. 2006..We conclude that microsaccade directionality does not determine, predict, or cause which figure will subsequently be perceived to undergo an illusory brightness change...
- Natural images and contrast encoding in bipolar cells in the retina of the land- and aquatic-phase tiger salamanderDwight A Burkhardt
Departments of Psychology and Graduate Program of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
Vis Neurosci 23:35-47. 2006..As a result, the dynamic range of the bipolar cell population brackets the distribution of contrasts found in natural images...
- Variations in normal color vision. IV. Binary hues and hue scalingGokhan Malkoc
Department of Psychology, University of Nevada, Reno, Nevada 89557, USA
J Opt Soc Am A Opt Image Sci Vis 22:2154-68. 2005..green and yellow vs. green categories. This suggests a weak tie between the cone-opponent axes and the structure of color appearance...
- Seeing unique huesIsrael Abramov
Department of Psychology, Applied Vision Institute, Brooklyn College City University of New York, Brooklyn, New York 1121, USA
J Opt Soc Am A Opt Image Sci Vis 22:2143-53. 2005....
- Characterising mesopic spectral sensitivity from reaction timesH C Walkey
Applied Vision Research Centre, The Henry Wellcome Laboratories for Vision Sciences, City University, London, EC1V 0HB, UK
Vision Res 46:4232-43. 2006..The second model produced a significantly better fit to the data. The chromatic mechanisms appear to contribute to reaction time when there is an appreciable chromatic signal but luminance contrast is low...
- Sinusoid = light bar + dark bar?W McIlhagga
Optometry Department, Bradford University, UK
Vision Res 46:1934-45. 2006..The model accounts for the data very well, and also accounts for contrast discrimination of light and dark edges...
- Development of a technique for recording the focal rod ERGAlison Binns
School of Optometry and Vision Sciences, Cardiff University, Wales, UK
Ophthalmic Physiol Opt 26:71-9. 2006..However, the Background Adaptation technique was found to more reliably elicit a focal response with a measurable a-wave, and was also considerably less time consuming than the Subtraction technique...
- Dynamic grouping and interpolation induced by flickering stimuliHiroyuki Sasaki
Department of Child Education, Niigata Chuoh Junior College, Japan
Perception 36:471-4. 2007..From these results, it is concluded that flicker-induced grouping reflects multiple stages of visual processing...
- Two distinct cone-opponent processes in the L+M luminance pathwaySei ichi Tsujimura
Department of Bioengineering, Kagoshima University, Kagoshima, Japan
Vision Res 47:1839-54. 2007..These facts suggest that suppression by the cone-opponent process for background color substitution is different from the one for a steady colored background...
- Contrast-reversing global-motion stimuli reveal local interactions between first- and second-order motion signalsMark Edwards
School of Psychology, Australian National University, Room 125B, Building 39, Canberra ACT0200, Australia
Vision Res 44:1941-50. 2004..These manipulations resulted in an increase in the perception of (first-order mediated) reverse-phi motion. We conclude that interaction between first- and second-order motion signals occur at the local-motion-pooling level...
- Electroretinographic abnormalities in parents of patients with Leber congenital amaurosis who have heterozygous GUCY2D mutationsRobert K Koenekoop
McGill Ocular Genetics Laboratory, Montreal Children s Hospital, McGill University, Montreal, Quebec, Canada
Arch Ophthalmol 120:1325-30. 2002..In the future, LCA may become treatable by gene and/or pharmacological intervention, and these therapies will likely be gene specific, giving major significance to rapid gene identification and gene-phenotype studies...
- The scotopic threshold response of the dark-adapted electroretinogram of the mouseShannon M Saszik
College of Optometry, University of Houston, Houston, TX 77204 2020, USA
J Physiol 543:899-916. 2002..These results support the use of the mouse ERG in studies of proximal retinal function...
- Modelling divergence in luminance and chromatic detection performance across measured divergence in surfperch (Embiotocidae) habitatsMolly E Cummings
Department of Ecology, Evolution and Marine Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
Vision Res 44:1127-45. 2004..Estimated performances for luminance detection were consistently high, while chromatic detection varied by habitat and demonstrated substantial improvements with increasing optical density differences between cone classes...
- Refractive compensation to optical defocus depends on the temporal profile of luminance modulation of the environmentD P Crewther
School of Psychological Science, La Trobe University, Melbourne, Australia
Neuroreport 13:1029-32. 2002..Thus the refractive compensation mechanism depends on the nature of the temporal contrast of the environment, suggesting a relationship between the sign of defocus and the state of adaptation of the retinal ON and OFF subsystems...
- Colour and luminance interactions in the visual perception of motionAlexandra Willis
School of Psychology and Sociology, Napier University, Craighouse Road, Edinburgh EH10 5LG, UK
Proc Biol Sci 269:1011-6. 2002..We argue that such mechanisms most probably lie within a parvocellular-dominated cortical visual pathway, sensitive to both chromatic and luminance modulation, but only weakly selective for the direction of stimulus motion...
- Background adaptation in a rat model of retinopathy of prematurityJohn Chunguang Jiang
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Doc Ophthalmol 104:97-105. 2002..The effect of the background light is consistent with receptoral disease causing low dark adapted b-wave sensitivity in ROP rats...
- Colour constancy and conscious perception of changes of illuminantJohn L Barbur
Applied Vision Research Centre, The Henry Wellcome Laboratories for Vision Sciences, City University, Northampton Square, London EC1V 0HB, UK
Neuropsychologia 46:853-63. 2008..The results show that the processing of ICC signals generates strong activation in V1 and the fusiform colour area (V4, V4A). Significant activation was also observed in areas V2 and V3...
- Adaptation to temporal contrast in primate and salamander retinaD Chander
Systems Neurobiology, The Salk Institute, La Jolla, California 92037-1099, USA
J Neurosci 21:9904-16. 2001..Functionally defined subclasses of ON and OFF cells also exhibited asymmetric adaptation. These findings indicate that contrast adaptation differs in parallel retinal circuits that convey distinct visual signals to the brain...
- Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptationM J Kennedy
Department of Biochemistry, Box 357350, University of Washington, 98195, Seattle, WA, USA
Neuron 31:87-101. 2001..Initially during dark adaptation, transduction activity wanes as multiple phosphates accumulate. Thereafter, full recovery of photosensitivity coincides with regeneration and dephosphorylation of rhodopsin...
- GABAa and GABAc receptor mediated influences on the intensity-response functions of the b- and d-wave in the frog ERGP Kupenova
Department of Physiology, Medical University, 1 G, Sofiiski Str, 1431 Sofia, Bulgaria
Vision Res 48:882-92. 2008..The effects of GABAc receptor blockade were more pronounced in dark adaptation conditions. They didn't vary much with stimulus intensity and showed little ON/OFF-response asymmetry...
- Primate photopic sine-wave flicker ERG: vector modeling analysis of component origins using glutamate analogsM Kondo
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
Invest Ophthalmol Vis Sci 42:305-12. 2001..These results can be summarized by a vector model that may be useful for interpreting changes resulting from retinal disease...
- Time course of rod influences on hue perceptionSteven L Buck
Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
Vis Neurosci 25:517-20. 2008..These opposing rod influences may reflect competing effects of rod signals on ML-cone and S-cone pathways...
- Surface gloss and color perception of 3D objectsBei Xiao
Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Vis Neurosci 25:371-85. 2008..In addition, the effect of glossy highlights on the color appearance of the test patch was consistent with the results from Experiment 1...
- Contrast adaptation may enhance contrast discriminationGiulia Abbonizio
Department of Psychology, University College London, London, UK
Spat Vis 16:45-58. 2002..The former study used binocular, while the latter study used monocular viewing with an occluding eyepatch...
- A parametric account of contrast adaptation on contrast perceptionKeith Langley
Department of Psychology, University College London, London, UK
Spat Vis 16:77-93. 2002..This saturation appears to be inconsistent with the commonly held view that the orientation specific effect represents a functional strategy used by the visual system to combat the problem of neural saturation in response firing rates...
- Foveal and extra-foveal orientation discriminationSharon L Sally
Department of Cognitive Science, Rutgers University, Piscataway, NJ, 08854, USA
Exp Brain Res 183:351-60. 2007..size) at the fovea than in the periphery. This explains why less spatial scaling is required to equate foveal and peripheral acuity functions at low contrasts than at high contrasts...
- Defining the detection mechanisms for symmetric and rectified flicker stimuliAndrew J Zele
Department of Optometry and Vision Sciences, The University of Melbourne, Vic, Australia
Vision Res 47:2700-13. 2007..The dynamics of the thresholds for symmetric and rectified flicker stimuli suggest the detection mechanisms occur early in the visual pathways, involving the magnocellular pathway...
- Grouping effects in flash-induced perceptual fadingMark L T Vergeer
Nijmegen Institute for Cognition and Information NICI, Radboud University Nijmegen, PO Box 9104, 6500 HE Nijmegen, The Netherlands
Perception 36:1036-42. 2007..This indicates that, besides low-level adaptation, more global processes play a part in perceptual fading as well and should thus be taken into account in giving a full explanation of perceptual fading in general...
- Interocular amplitude differences of the full field electroretinogram in normal subjectsY Rotenstreich
Department of Ophthalmology and Visual Science, University of Illinois at Chicago, 1855 W Taylor, Chicago, IL 60612, USA
Br J Ophthalmol 87:1268-71. 2003..To determine the interocular amplitude response difference of the electroretinogram (ERG) in normal subjects...
- Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- miceClaudia M Krispel
Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
J Neurosci 23:6965-71. 2003..In addition, our light adaptation studies support the notion than an additional weak GTPase-accelerating factor in rods is regulated by intracellular calcium and/or cGMP...
- Visible light induces matrix metalloproteinase-9 expression in rat eyeAndrea M Papp
Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
J Neurochem 103:2224-33. 2007..This is the first demonstration of MMP-9 induction by a sensory stimulus...
- A method for investigating the temporal dynamics of local neuroretinal responsesBeatrix Feigl
Institute of Health and Biomedical Innovation and the School of Optometry, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, 4059 QLD, Australia
J Neurosci Methods 167:207-12. 2008..The time-slice mfERG waveform is a technique for assessing the temporal dynamics of cone-generated neural responses over time. The data are interpreted in terms of the vascular supplies and lower-level visual adaptation mechanisms...
- Visual adaptations in a diurnal rodent, Octodon degusG H Jacobs
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189:347-61. 2003..In behavioral tests degus were shown to be able to make color discriminations between ultraviolet and visible lights...
- Noninvasive recording and response characteristics of the rat dc-electroretinogramNeal S Peachey
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Vis Neurosci 19:693-701. 2002....
- The photopic ERG luminance-response function (photopic hill): method of analysis and clinical applicationMarianne Rufiange
Department of Ophthalmology D 164, McGill University, Montreal Children s Hospital Research Institute, 2300 Tupper Street, Que, H3H 1P3, Montreal, Canada
Vision Res 43:1405-12. 2003..The clinical usefulness of these parameters is illustrated with selected cases of retinal disorders...
- Do weak adapting backgrounds uncover multiple components in the electroretinogram of the horseshoe crab?J C Lucas
Department of Applied Biology and Biomedical Engineering, Rose Hulman Institute of Technology, Terre Haute, IN 47803, USA
Biomed Sci Instrum 39:105-10. 2003..This is in contrast with analogous results from mammals, including mouse, cat and monkey, which show multiple stages of adaptation within their more complex retinas...
- Anterior chamber depth and primary angle-closure glaucoma: an evolutionary perspectiveRobert J Casson
South Australian Institute of Ophthalmology, Adelaide University, South Australia, Australia
Clin Experiment Ophthalmol 36:70-7. 2008..evidence for migration patterns of early humans are discussed and the notions of natural selection and ocular adaptation to cold climates are considered...
- Learning in the oculomotor system: from molecules to behaviorJ L Raymond
Department of Neurobiology, Stanford University School of Medicine, Sherman Fairchild Building, Room 251, Stanford, California 94305, USA
Curr Opin Neurobiol 8:770-6. 1998..Studies of vestibulo-ocular adaptation are beginning to examine the molecular pathways contributing to this form of cerebellum-dependent learning.
- Eye rotation does not contribute to shifts in subjective straight ahead: implications for prism adaptation and neglectRoger Newport
School of Psychology, University of Nottingham, University Park, Nottingham, UK
Neuropsychologia 47:2008-12. 2009..Rotating the eye alone did not contribute to SSA realignment whereas shifting the hand did...
- Localizations of visual cycle components in retinal pigment epitheliumJing Huang
Department of Ophthalmology, University of Washington, School of Medicine, Seattle, WA, USA
Mol Vis 15:223-34. 2009..The localizations of these enzymes were compared to known localizations of retinoid-binding proteins and associated proteins...
- How fast can we adapt?Narcis Ghisovan
Department of Biological Sciences, University of Montreal, C P 6128, succursaleCentre ville Montreal, QC H3C 3J7, Canada
J Physiol 586:1213-4. 2008
- Adaptation responses in early age-related maculopathyBeatrix Feigl
Centre for Health Research, School of Optometry, Queensland University of Technology, Brisbane, Australia
Invest Ophthalmol Vis Sci 46:4722-7. 2005..To investigate the global-flash multifocal electroretinogram (mfERG) in early age-related maculopathy (ARM)...
- Neuroadaptation of presbyopia-correcting intraocular lensesSusan M Pepin
Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Curr Opin Ophthalmol 19:10-2. 2008..Technology is only improving these options for presbyopic-correcting intraocular lenses. Surgeons must consider the possible neuroadaptation abilities in patients that may help in the success of using these lenses...
- [Changes in the spatial-contrast sensitivity during work with liquid-crystal monitors and with spectral correction of vision]A A Feĭgin
Fiziol Cheloveka 31:123-5. 2005
- VISUAL ADAPTATION LIMITS AND AGE-RELATED DISEASEAlvin Eisner; Fiscal Year: 2002....
- WITHIN-SPECIES VARIATIONS IN VISUAL CAPACITYGERALD JACOBS; Fiscal Year: 2007..unreadable] [unreadable]..
- Visual Dysfunction in Retinal DegenerationsKenneth R Alexander; Fiscal Year: 2010....
- Female Hormones and VisionAlvin Eisner; Fiscal Year: 2006..abstract_text> ..
- Information transfer through ganglion cellsBarry Lee; Fiscal Year: 2010..abstract_text> ..
- COMPUTATIONAL ANALYSIS OF CONE PHOTOTRANSDUCTIONRUSSELL HAMER; Fiscal Year: 2005..Similarly, such models allow one to conceptualize and test, noninvasively, putative mechanisms underlying retinal diseases affecting photoreceptor function, and also to identify receptoral immaturities in developing visual systems. ..
- Fractionating visual face perceptionRichard Russell; Fiscal Year: 2008..These hypotheses will be tested using rigorous psychophysics with a group of developmental prosopagnosic individuals. [unreadable] [unreadable] [unreadable]..
- Retinal Inputs to the Mammalian Circadian PacemakerKWOON WONG; Fiscal Year: 2006..These experiments may enable a better understanding of how the mammalian circadian pacemaker is regulated, which in turn may lead to better therapies and workplace policies combating/preventing jet lag problems. ..
- Gene Therapy of Autosomal Recessive RPSimon Petersen Jones; Fiscal Year: 2006..abstract_text> ..
- High Throughput Assays for Ion Channel Activities of Influenza A & B VirusesLAWRENCE PINTO; Fiscal Year: 2006..These assays will make it possible to perform efficient searches for antiviral drugs against the M2 ion channels. [unreadable] [unreadable] [unreadable] [unreadable]..
- Short-term Training Students-Health Professional SchoolsKENNETH CIUFFREDA; Fiscal Year: 2006..Trainees will consist of optometry students who have just completed either their first or second professional years, and have done well academically (3.5 gpa or better). All will have an undergraduate degree, generally in the sciences. ..
- Visual Coding and the Statistics of Natural ScenesDaniel Graham; Fiscal Year: 2006..By determining the mechanisms at work in coding early vision, our study may suggest new therapeutic strategies in the retina and new technologies in synthetic vision. ..
- RESPIRATORY VIRUS ION CHANNELSLAWRENCE PINTO; Fiscal Year: 2007..5. In a separate set of experiments we will use a sensitive method to test the NB protein of influenza B virus for ion channel activity. [unreadable] [unreadable] [unreadable]..
- LIFE AND DEATH OF RETINAL GANGLION CELLSVittorio Porciatti; Fiscal Year: 2007..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
- PSYCHOPHYSICAL STUDIES OF COLOR DEFECTIVE VISIONJoel Pokorny; Fiscal Year: 2006....
- Visually Modulated Endogenous ActivityErich Sutter; Fiscal Year: 2005..We will investigate its dependence on stimulus geometry and color and we will compare the VMEA responses to random patterns with those to meaningful images with similar brightness contrast distributions. ..
- COORDINATE TRANSFORMATION IN AFTEREFFECTS AND ATTENTIONShinsuke Shimojo; Fiscal Year: 2007..The results will bridge the gap between animal physiology and human psychophysics, providing insights into coordinate transformation. [unreadable] [unreadable]..
- CRCNS: Complete functional characterization of a population of retinal ganglion cEDUARDO J CHICHILNISKY; Fiscal Year: 2010..In summary, knowing how the entire retinal network encodes the visual scene in spike trains is a key element in understanding the healthy visual system and designing prosthetic treatments for retinas damaged by disease. ..
- Low-Level Prenatal Lead Exposure and Retinal ToxicityDonald Fox; Fiscal Year: 2009....
- High Throughput Mapping of Neuronal and Glial NetworksGabriel A Silva; Fiscal Year: 2010..abstract_text> ..
- Synchronized Firing in the RetinaEDUARDO CHICHILNISKY; Fiscal Year: 2009....
- BINOCULAR RIVALRY IN HUMAN VISIONRobert Blake; Fiscal Year: 2009..Finally, results from these experiments will guide neurophysiologists and cognitive neuroscientists seeking to discover the actual neural concomitants of multi-stable perception. ..
- Studies on Influenza B Virus BM2 Protein Ion ChannelLAWRENCE PINTO; Fiscal Year: 2009....
- Manganese-enhanced MRI Studies of Retinal NeovascularizationBRUCE BERKOWITZ; Fiscal Year: 2008..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
- Glutamate Signaling in Human Islets of LangerhansALEJANDRO CAICEDO VIERKANT; Fiscal Year: 2007..unreadable] [unreadable]..
- Zebrafish Mutant Mapping FacilityRonald Gregg; Fiscal Year: 2007..unreadable] [unreadable]..
- GLUTAMATE NEUROTRANSMISSION IN RAT TASTE BUDSAlejandro Caicedo; Fiscal Year: 2002..Evidence for glutamatergic synapses and for efferent modulation in taste buds will modify current models of how sensory information is encoded in the peripheral gustatory system. ..
- DEVELOPMENT OF AUDITORY-VISUAL LOCALIZATIONShinsuke Shimojo; Fiscal Year: 2003....
- CEREBELLAR NUCLEI IN EYE MOVEMENT CONTROL AND ADAPTATIONFarrel Robinson; Fiscal Year: 2003..This unified view of two apparently different CFN functions would provide the first explicit model for understanding the role of other cerebellar output in controlling and adapting other voluntary movements. ..
- PHOTORECEPTOR MUTATIONSSUSAN BROCKERHOFF; Fiscal Year: 2003..As a first step towards this end, we will generate a database of retina-specific genes and map these genes. ..
- ERG FIELD TOPOGRAPHY AND SOURCE IDENTIFICATIONErich Sutter; Fiscal Year: 2003..3. To test the hypothesis that the range and dynamics of the components investigated under 1. are sensitive indicators of retinal ischemia in diabetes. To develop a method to map functional changes in diabetes. ..
- IRON STATUS IN WOMEN OF REPRODUCTIVE AGEUsha Ramakrishnan; Fiscal Year: 2002..The investigators state that in summary, the project is expected to provide information that can be used to examine policy options and develop guidelines to ensure adequate but safe iron status for women of reproductive age. ..
- VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGINGSergei Yakushin; Fiscal Year: 2002..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..
- DOPAMINE AND RETINAL ADAPTATIONPaul Witkovsky; Fiscal Year: 2001....
- CELLULAR SIGNAL PROCESSING IN FLY MOTION VISIONAlexander Borst; Fiscal Year: 2001..The experimental data undergo an information theoretic analysis and compared to the performance of biophysically realistic computer models of the cells. ..
- MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITYBRUCE BERKOWITZ; Fiscal Year: 2001..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
- VISION AND INTRARETINAL POTENTIALSDWIGHT BURKHARDT; Fiscal Year: 2003..feedback pathways in mediating the surround of the bipolar cell receptive field and d) Studies of the mechanisms mediating large-field noise, surround antagonism, and spatial resolution in bipolar cells. ..
- Retinal Oxygenation in Diabetic RetinopathyBRUCE BERKOWITZ; Fiscal Year: 2004..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
- Improved Acoustic Detection of Coronary BlockagesJohn Semmlow; Fiscal Year: 2005..Specifically, a successful outcome of Phase I will be the ability to detect blockages of 30% to 85% with a sensitivity greater than > 90 % and a specificity greater than 80% in a retrospective data analysis. ..
- Cue Combination in Bistable, 3d Structure-From-MotionLee Gilroy; Fiscal Year: 2005....
- EFFECTIVE CONNECTIVITY IN BRAIN IMAGING OF VISIONRobert Blake; Fiscal Year: 2005..The present proposal has this potential. ..
- PHOTIC SENSITIVITY OF THE CIRCADIAN ENTRAINMENT PATHWAYDWIGHT NELSON; Fiscal Year: 2004....
- Learning and Adaptation in Primary Visual CortexANDREW TEICH; Fiscal Year: 2005..The goal of Specific Aim 2 is to experimentally test the prediction that adaptation in alert, non-anesthetized subjects causes physiological changes that are a transient version of the changes seen in learning. ..
- Role of Oculomotor Vermis Parallel Fibers in SaccadesFarrel Robinson; Fiscal Year: 2005..Saccades will not decelerate enough so they will overshoot their targets. The work proposed here will conclusively test this hypothesis by measuring saccades after we cut the p-fibers in the eye movement part of the cerebellum. ..
- Cortical Mechanisms of Spatial Pattern VisionLYNN OLZAK; Fiscal Year: 2004..We propose to begin to characterize these properties quantitatively. ..
- ENSEMBLE CODING OF VISUAL INFORMATION IN THE RETINAEDUARDO CHICHILNISKY; Fiscal Year: 2004..Aim 3. Does retinal signaling limit accuracy of behavioral and cortical motion sensing? This part will include psychophysical studies as well as correlation with recordings in MT obtained from other investigators. ..
- FEMTOSECOND TWO PHOTON LASER SCANNING MICROSCOPEPeter Detwiler; Fiscal Year: 2001..The instrument will be heavily used by each of the three investigators since the microscope would be engaged on a daily basis in experiments that will run for several hours. ..
- MECHANISMS OF PERCEPTUAL ORGANIZATION IN HUMAN VISIONRobert Blake; Fiscal Year: 2005..In addition, the work on spatial structure from temporal synchrony may have implications for understanding clinical disorders involving disruptions in temporal processing, including dyslexia. ..