intraocular pressure

Summary

Top Publications

  1. ncbi Predictors of long-term progression in the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University Medical Center, Stony Brook, New York 11794 8036, USA
    Ophthalmology 114:1965-72. 2007
  2. doi 24-hour intraocular pressure and ocular perfusion pressure in glaucoma
    Luciano Quaranta
    Department of Ophthalmology, University of Brescia, Brescia, Italy
    Surv Ophthalmol 58:26-41. 2013
  3. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
  4. ncbi Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Health Sciences Center, L3 086, Stony Brook, NY 11794 8036, USA
    Arch Ophthalmol 121:48-56. 2003
  5. ncbi The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study
    Aiko Iwase
    Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
    Ophthalmology 111:1641-8. 2004
  6. ncbi Central corneal thickness and corneal hysteresis associated with glaucoma damage
    Nathan G Congdon
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Ophthalmol 141:868-75. 2006
  7. doi Cerebrospinal fluid pressure in glaucoma: a prospective study
    Ruojin Ren
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Ophthalmology 117:259-66. 2010
  8. pmc Early microglia activation in a mouse model of chronic glaucoma
    Alejandra Bosco
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84132, USA
    J Comp Neurol 519:599-620. 2011
  9. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
  10. ncbi Determining in vivo biomechanical properties of the cornea with an ocular response analyzer
    David A Luce
    Reichert Inc, Depew, New York, USA
    J Cataract Refract Surg 31:156-62. 2005

Research Grants

Detail Information

Publications368 found, 100 shown here

  1. ncbi Predictors of long-term progression in the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University Medical Center, Stony Brook, New York 11794 8036, USA
    Ophthalmology 114:1965-72. 2007
    To determine progression factors at the end of the Early Manifest Glaucoma Trial (EMGT) based on all EMGT patients and evaluate separately patients with higher and lower baseline intraocular pressure (IOP; median split).
  2. doi 24-hour intraocular pressure and ocular perfusion pressure in glaucoma
    Luciano Quaranta
    Department of Ophthalmology, University of Brescia, Brescia, Italy
    Surv Ophthalmol 58:26-41. 2013
    This review analyzes the currently available literature on circadian rhythms of intraocular pressure (IOP), blood pressure, and calculated ocular perfusion pressure (OPP) in patients with open-angle glaucoma...
  3. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
    ..According to the mechanical theory, increased intraocular pressure (IOP) causes stretching of the laminar beams and damage to retinal ganglion cell axons...
  4. ncbi Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Health Sciences Center, L3 086, Stony Brook, NY 11794 8036, USA
    Arch Ophthalmol 121:48-56. 2003
    ..To assess factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of EMGT treatment...
  5. ncbi The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study
    Aiko Iwase
    Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
    Ophthalmology 111:1641-8. 2004
    To assess the prevalence of primary open-angle glaucoma (POAG) and its association with intraocular pressure (IOP) in Tajimi City in central Japan.
  6. ncbi Central corneal thickness and corneal hysteresis associated with glaucoma damage
    Nathan G Congdon
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Ophthalmol 141:868-75. 2006
    ..We sought to measure the impact of central corneal thickness (CCT), a possible risk factor for glaucoma damage, and corneal hysteresis, a proposed measure of corneal resistance to deformation, on various indicators of glaucoma damage...
  7. doi Cerebrospinal fluid pressure in glaucoma: a prospective study
    Ruojin Ren
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Ophthalmology 117:259-66. 2010
    To assess whether a low cerebrospinal fluid pressure (CSF-P) is associated with open-angle glaucoma in eyes with normal intraocular pressure (IOP).
  8. pmc Early microglia activation in a mouse model of chronic glaucoma
    Alejandra Bosco
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84132, USA
    J Comp Neurol 519:599-620. 2011
    ..Ultimately, detection of microglial activation may have value in early disease diagnosis, while modulation of microglial responses may alter disease progression...
  9. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
    ..to 6 million people in the United States are at increased risk for developing POAG because of elevated intraocular pressure (IOP), or ocular hypertension...
  10. ncbi Determining in vivo biomechanical properties of the cornea with an ocular response analyzer
    David A Luce
    Reichert Inc, Depew, New York, USA
    J Cataract Refract Surg 31:156-62. 2005
    To study the results of an ocular response analyzer (ORA) to determine the biomechanical properties of the cornea and their relationship to intraocular pressure (IOP).
  11. ncbi Angle-closure glaucoma in an urban population in southern India. The Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1710-6. 2000
    ..To assess the prevalence and features of angle-closure glaucoma (ACG) in an urban population in southern India...
  12. pmc Extracellular matrix turnover and outflow resistance
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239 4197, USA
    Exp Eye Res 88:676-82. 2009
    Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling the extracellular matrix (ECM) of the trabecular meshwork (TM)...
  13. pmc Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia
    Megan Ulmer
    Duke University Center for Human Genetics, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 53:4468-74. 2012
    ....
  14. pmc Treatment outcomes in the Tube Versus Trabeculectomy (TVT) study after five years of follow-up
    Steven J Gedde
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Florida, USA
    Am J Ophthalmol 153:789-803.e2. 2012
    ..To report 5-year treatment outcomes in the Tube Versus Trabeculectomy (TVT) Study...
  15. doi Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma
    Ruojin Ren
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Graefes Arch Clin Exp Ophthalmol 249:1057-63. 2011
    ..The aim of this work is to prospectively assess the relationship between trans-laminar cribrosa pressure difference and neuroretinal rim area as morphologic surrogate of glaucomatous optic nerve damage...
  16. doi Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography
    Joshua R Ehrlich
    Department of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USA
    Exp Eye Res 92:189-94. 2011
    ..We conclude that eyes with POAG did not demonstrate reduced CT nor was there a correlation between RNFL and CT maps. This study does not support the use of CT assessment in glaucoma diagnosis or management...
  17. pmc Glaucoma: genes, phenotypes, and new directions for therapy
    Bao Jian Fan
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:3064-72. 2010
    ..cause of blindness worldwide, is characterized by progressive optic nerve damage, usually associated with intraocular pressure. Although the clinical progression of the disease is well defined, the molecular events responsible for ..
  18. ncbi Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye
    David Goldblum
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, USA
    Vision Res 42:471-8. 2002
    ..Here we review the different, current models in rodents that have been used to study RGC damage, discuss their value, and their adequacy as models for human glaucoma...
  19. doi Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model
    Daniel M Rosenbaum
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    J Neurosci Res 88:1569-76. 2010
    ..Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional impairment in a model of retinal ischemia...
  20. ncbi Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Vis Neurosci 22:637-48. 2005
    ..A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly...
  21. ncbi Open-angle glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study
    L Dandona
    Public Health Ophthalmology Service, L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 107:1702-9. 2000
    ..To assess the prevalence and features of open-angle glaucoma in an urban population in southern India...
  22. ncbi Risk factors for incident open-angle glaucoma: the Barbados Eye Studies
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York 11794 8036, USA
    Ophthalmology 115:85-93. 2008
    ..To evaluate risk factors for definite open-angle glaucoma (OAG), based on African-descent participants of the Barbados Eye Studies...
  23. ncbi Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage
    Balwantray C Chauhan
    Laboratory for Retina and Optic Nerve, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 43:2969-76. 2002
    To characterize the effect of intraocular pressure (IOP) on optic disc topography, retinal function, and axonal survival in a model of IOP-induced optic nerve damage in rat.
  24. ncbi Open-angle glaucoma and systemic hypertension: the blue mountains eye study
    Paul Mitchell
    Department of Ophthalmology, The University of Sydney, Sydney, Australia
    J Glaucoma 13:319-26. 2004
    ..To assess whether systemic hypertension is associated with open-angle glaucoma (OAG) in an older population...
  25. pmc Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection
    Frances E Cone
    Glaucoma Research Laboratory, Johns Hopkins University School of Medicine, Wilmer Institute, Wilmer 122, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Exp Eye Res 91:415-24. 2010
    ..We evaluated intraocular pressure (IOP) and damage to RGC as measured by optic nerve axon counts and RGC layer neuron counts in 3 strains of ..
  26. doi Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics
    Ranjay Chakraborty
    Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Brisbane, Queensland, Australia
    Invest Ophthalmol Vis Sci 52:5121-9. 2011
    To investigate the pattern of diurnal variations in axial length (AL), choroidal thickness, intraocular pressure (IOP), and ocular biometrics over 2 consecutive days.
  27. ncbi Method for the noninvasive measurement of intraocular pressure in mice
    John Danias
    Department of Ophthalmology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Invest Ophthalmol Vis Sci 44:1138-41. 2003
    ..To evaluate the applicability of rebound tonometry for measurement of IOP in the mouse eye...
  28. pmc Intraocular pressure control and long-term visual field loss in the Collaborative Initial Glaucoma Treatment Study
    David C Musch
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 118:1766-73. 2011
    To evaluate the impact of measures of intraocular pressure (IOP) control on progression of visual field (VF) loss during long-term treatment for open-angle glaucoma (OAG).
  29. doi Intraocular pressure and associated factors: the central India eye and medical study
    Jost B Jonas
    Suraj Eye Institute, Nagpur, Maharashtra, India
    J Glaucoma 20:405-9. 2011
    To determine the range of intraocular pressure (IOP) in a rural Central Indian population and to evaluate existing and identify potential new ocular, medical, and socioeconomic factors associated with IOP.
  30. ncbi Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats
    H A Quigley
    Glaucoma Research Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 41:3460-6. 2000
    ..To determine whether acute experimental glaucoma in rats obstructs retrograde transport of brain-derived neurotrophic factor (BDNF) to retinal ganglion cells (RGCs)...
  31. pmc Common genetic determinants of intraocular pressure and primary open-angle glaucoma
    Leonieke M E van Koolwijk
    Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands
    PLoS Genet 8:e1002611. 2012
    b>Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown...
  32. ncbi Twenty-four-hour pattern of mouse intraocular pressure
    Makoto Aihara
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093 0946, USA
    Exp Eye Res 77:681-6. 2003
    The 24-hr pattern of intraocular pressure in the mouse eye remains poorly characterized...
  33. ncbi Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program
    Hwa Sun Kim
    Department of Ophthalmology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Ku, Seoul 137 701, South Korea
    Brain Res 1057:17-28. 2005
    ..This study examined cell death in the retina after chronic elevation of intraocular pressure (IOP) in an experimental rat model of human glaucomatous disease...
  34. ncbi Molecular complexity of primary open angle glaucoma: current concepts
    Kunal Ray
    Molecular and Human Genetic Division, Indian Institute of Chemical Biology A unit of CSIR, Kolkata, India
    J Genet 88:451-67. 2009
    ..Here we present a mechanistic overview of potential pathways and crosstalk between them operating in POAG pathogenesis...
  35. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002
    ..topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage.
  36. pmc Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve
    Won Kyu Ju
    Department of Ophthalmology, Hamilton Glaucoma Center, School of Medicine, University of California San Diego, La Jolla, California 92037 0946, USA
    Invest Ophthalmol Vis Sci 49:4903-11. 2008
    To determine whether elevation of intraocular pressure (IOP) triggers mitochondrial fission and ultrastructural changes and alters optic atrophy type 1 (OPA1) expression and distribution in the optic nerve (ON) of glaucomatous DBA/2J mice.
  37. ncbi TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes
    G Tezel
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Invest Ophthalmol Vis Sci 42:1787-94. 2001
    ..To determine the expression and localization of tumor necrosis factor (TNF)-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes...
  38. doi Prevalence of glaucoma in North China: the Beijing Eye Study
    Ya Xing Wang
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Am J Ophthalmol 150:917-24. 2010
    ..To assess the prevalence of glaucoma in adult Chinese...
  39. ncbi Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS)
    J D Brandt
    Department of Ophthalmology, University of California-Davis, Sacramento, California, USA
    Ophthalmology 108:1779-88. 2001
    OBJECTIVE: Central corneal thickness influences intraocular pressure (IOP) measurement...
  40. ncbi Factors for progression and glaucoma treatment: the Early Manifest Glaucoma Trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York, USA
    Curr Opin Ophthalmol 15:102-6. 2004
    ..EMGT randomized patients with early glaucoma either to argon laser trabeculoplasty plus betaxolol (n = 129) or to no immediate treatment (n = 126) and followed them every 3 months...
  41. pmc Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography
    O Rese J Knight
    Bascom Palmer Eye Institute, Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami 33136, Florida, USA
    Ophthalmology 116:1271-7. 2009
    ....
  42. doi Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients
    Anthony P Wells
    Capital Eye Specialists, Wellington, New Zealand
    Invest Ophthalmol Vis Sci 49:3262-8. 2008
    To investigate relationships between acute intraocular pressure (IOP)-induced optic nerve head surface deformation and corneal hysteresis and thickness in glaucomatous and nonglaucomatous human eyes.
  43. doi Neuroprotection in glaucoma: recent and future directions
    Helen V Danesh-Meyer
    Department of Ophthalmology, University of Auckland, Auckland, New Zealand
    Curr Opin Ophthalmol 22:78-86. 2011
    ..This review focuses on strategies for neuroprotection and summarizes preclinical studies that have investigated potential agents over the last 2 years...
  44. doi Biomechanical properties of the cornea measured by the Ocular Response Analyzer and their association with intraocular pressure and the central corneal curvature
    Sandra Franco
    Physics Department Optometry, University of Minho, Portugal
    Clin Exp Optom 92:469-75. 2009
    The aim of this study was to investigate the biomechanical properties of the cornea and their association with intraocular pressure (IOP), central corneal thickness (CCT) and the central corneal radius of curvature (Rc).
  45. doi Deformation of the rodent optic nerve head and peripapillary structures during acute intraocular pressure elevation
    Brad Fortune
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 52:6651-61. 2011
    PURPOSE. To evaluate the effect of acutely elevated intraocular pressure (IOP) on retinal thickness and optic nerve head (ONH) structure in the rat eye by spectral domain-optical coherence tomography (SD-OCT). METHODS...
  46. doi Intraocular pressure and related systemic and ocular biometric factors in a population-based study in Japan: the Kumejima study
    Eriko Tomoyose
    Department of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, Japan
    Am J Ophthalmol 150:279-86. 2010
    To examine the distribution of intraocular pressure (IOP) and its related systemic and ocular biometric factors in a population-based study in a southwestern island of Japan.
  47. pmc Effect of acute intraocular pressure elevation on the monkey optic nerve head as detected by spectral domain optical coherence tomography
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health, Portland, Oregon 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:9431-7. 2011
    ..To determine whether acutely elevated IOP alters optic nerve head (ONH) structural parameters characterized in vivo using spectral domain optical coherence tomography (SD-OCT)...
  48. doi Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics
    Scott A Read
    Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Brisbane, Queensland, Australia
    Invest Ophthalmol Vis Sci 49:2911-8. 2008
    To investigate the diurnal variation in axial length and anterior eye biometrics, while simultaneously measuring intraocular pressure (IOP) with dynamic contour tonometry in human subjects.
  49. doi Femtosecond lenticule extraction (FLEx): clinical results, interface evaluation, and intraocular pressure variation
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 53:1414-21. 2012
    To characterize the clinical profile of femtosecond lenticule extraction (FLEx) correlated with ultrastructural analysis of the corneal interface and in vivo real-time intraocular pressure (IOP).
  50. pmc Postoperative complications in the Tube Versus Trabeculectomy (TVT) study during five years of follow-up
    Steven J Gedde
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Florida, USA
    Am J Ophthalmol 153:804-814.e1. 2012
    ..To describe postoperative complications encountered in the Tube Versus Trabeculectomy (TVT) Study during 5 years of follow-up...
  51. doi Intraocular pressure and its relationship to ocular and systemic factors in a healthy Chinese rural population: the Handan Eye Study
    Qiang Zhou
    Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Ophthalmic Epidemiol 19:278-84. 2012
    To describe the distribution of and factors related to intraocular pressure (IOP) in a healthy adult rural Chinese population in northern China.
  52. ncbi Intraocular pressure over the clinical range of blood pressure: blue mountains eye study findings
    Paul Mitchell
    Department of Ophthalmology, University of Sydney, Australia
    Am J Ophthalmol 140:131-2. 2005
    To quantify the relation of blood pressure (BP) and intraocular pressure (IOP) across the clinical range of BP in an older phakic population not using glaucoma medications.
  53. doi Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study
    Ningli Wang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Ophthalmology 119:2065-2073.e1. 2012
    ..We measured the optic nerve subarachnoid space width (ONSASW) as a surrogate for orbital CSF-P in patients with primary open-angle glaucoma (POAG) with normal and high pressure and a control group...
  54. ncbi Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development
    R S Smith
    The Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 9:1021-32. 2000
    ..disorders, including Axenfeld-Rieger anomaly (ARA), variably associate with harmfully elevated intraocular pressure (IOP), which causes glaucoma...
  55. doi The relationship of intraocular pressure with age, systolic blood pressure, and central corneal thickness in an asian population
    Tina T Wong
    Singapore Eye Research Institute and Singapore National Eye Centre, Singapore the
    Invest Ophthalmol Vis Sci 50:4097-102. 2009
    To describe the distribution of intraocular pressure (IOP) and its cross-sectional relationship to age, systolic blood pressure (sBP), and central corneal thickness (CCT) in an Asian population.
  56. doi The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma
    Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Exp Eye Res 93:141-55. 2011
    ..The most important risk factor for the disease is an increased intraocular pressure (IOP). Reducing IOP is associated with reduced progression in glaucoma...
  57. ncbi The effects of acute intraocular pressure elevation on rat retinal glutamate transport
    David J Holcombe
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
    Acta Ophthalmol 86:408-14. 2008
    To investigate the relationship between intraocular pressure (IOP), retinal glutamate transport and retinal hypoxia during acute IOP elevations of varying magnitude.
  58. doi Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice
    Nicolas Cuenca
    Departamento de Fisiologia, Genética y Microbiología, Universidad de Alicante, 03690 San Vicente del Raspeig, Alicante E 03080, Spain
    Exp Eye Res 91:273-85. 2010
    In adult albino mice the effects of increased intraocular pressure on the outer retina and its circuitry was investigated at intervals ranging 3-14 weeks...
  59. ncbi Anatomic relationship between lamina cribrosa, intraocular space, and cerebrospinal fluid space
    Jost B Jonas
    Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Invest Ophthalmol Vis Sci 44:5189-95. 2003
    ..The function as a pressure barrier may have importance for the pathogenesis of ocular diseases related to intraocular pressure and/or cerebrospinal fluid (CSF) pressure, such as the glaucomas...
  60. doi Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma
    Anton Hommer
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 49:4046-50. 2008
    ..In this study, the hypothesis was that patients with primary open-angle glaucoma (POAG) have an abnormal ocular structural stiffness based on measurements of intraocular pressure amplitude and ocular fundus pulsation amplitude (FPA).
  61. ncbi Risk factors for progression of visual field abnormalities in normal-tension glaucoma
    S Drance
    Bascom Palmer Eye Institue, Miami, FL 33101-6880, USA
    Am J Ophthalmol 131:699-708. 2001
    ..collaborative normal-tension glaucoma study during intervals in which the eye under study was not receiving intraocular pressure-lowering treatment during prerandomization and postrandomization intervals...
  62. doi Incidence of glaucomatous visual field loss: a ten-year follow-up from the Rotterdam Study
    Monika A Czudowska
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 117:1705-12. 2010
    ..To determine the 10-year incidence of glaucomatous visual field loss (GVFL) and to investigate the influence of risk factors for open-angle glaucoma on this incidence...
  63. doi Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure
    Tamotsu Seki
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa, Tokyo 142 8555, Japan
    J Mol Neurosci 43:30-4. 2011
    Glaucoma is a neurodegenerative disease in which increasing intraocular pressure leads to the progressive loss of retinal ganglion cells (RGCs) and blindness...
  64. pmc Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma
    John C Morrison
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Ceres, 3375 SW Terwilliger Bvld, Portland, OR 97239, USA
    Exp Eye Res 93:156-64. 2011
    ..However, determining cellular responses to elevated intraocular pressure (IOP) and relating their contribution to axonal injury require cell biology techniques, using animals in ..
  65. doi Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser
    J R Ehrlich
    Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA
    Eye (Lond) 24:1555-60. 2010
    To compare agreement of intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT) and Goldmann correlated intraocular pressure generated (IOPg) by the Reichert ocular response analyser (ORA).
  66. pmc Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure
    Antonio Piras
    Neuroscience Institute of the Cavalieri Ottolenghi Foundation, Orbassano, Torino, Italy
    PLoS ONE 6:e22514. 2011
    Acute primary open angle glaucoma is an optic neuropathy characterized by the elevation of intraocular pressure, which causes retinal ischemia and neuronal death...
  67. ncbi Glaucoma in a rural population of southern India: the Aravind comprehensive eye survey
    R Ramakrishnan
    Aravind Eye Care System, Madurai, Tamil Nadu, India
    Ophthalmology 110:1484-90. 2003
    ..To determine the prevalence of glaucoma and risk factors for primary open-angle glaucoma in a rural population of southern India...
  68. ncbi Glaucoma in Zulus: a population-based cross-sectional survey in a rural district in South Africa
    Alan P Rotchford
    International Centre for Eye Health, Institute of Ophthalmology, 11 43 Bath St, London EC1V 9EL, England
    Arch Ophthalmol 120:471-8. 2002
    ..To determine the prevalence and the main types of glaucoma in a representative adult population in rural Zululand, and to describe the distribution of glaucoma-related variables in healthy subjects and those with glaucoma...
  69. ncbi Corneal hysteresis and intraocular pressure measurement in children using the reichert ocular response analyzer
    Caitriona Kirwan
    Childrens University Hospital, Dublin, Ireland
    Am J Ophthalmol 142:990-2. 2006
    To examine corneal hysteresis in children with normal eyes and congenital glaucoma and assess intraocular pressure (IOP) measurement with the Reichert Ocular Response Analyzer (RORA).
  70. ncbi Spectral content of the intraocular pressure pulse wave: glaucoma patients versus normal subjects
    David W Evans
    Department of Optometry, School of Optometry, University of Alabama at Birmingham, Alabama, USA
    Graefes Arch Clin Exp Ophthalmol 240:475-80. 2002
    Many studies have found that the intraocular pressure (IOP) is lower in glaucomatous populations than in normal groups...
  71. ncbi Changes in corneal biomechanics and intraocular pressure following LASIK using static, dynamic, and noncontact tonometry
    Jay S Pepose
    Pepose Vision Institute, 16216 Baxter Road, Chesterfield, MO 63017, USA
    Am J Ophthalmol 143:39-47. 2007
    To compare the preoperative and postoperative measurement of corneal biomechanical properties and intraocular pressure (IOP) using Goldmann applanation tonometry (GAT), the ocular response analyzer (ORA), and the Pascal dynamic contour ..
  72. ncbi Adult-onset primary open-angle glaucoma caused by mutations in optineurin
    Tayebeh Rezaie
    Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:1077-9. 2002
    ..7% of families with hereditary POAG, including individuals with normal intraocular pressure. The OPTN gene codes for a conserved 66-kilodalton protein of unknown function that has been implicated in ..
  73. ncbi Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:31240-8. 2005
    ..The possibility that altered IL-18 expression in the eye of DBA/2J mice initiates and/or amplifies the pathogenesis of pigmentary glaucoma requires further investigation...
  74. pmc Prospective case control study on genetic assocation of apolipoprotein epsilon2 with intraocular pressure
    A Junemann
    Br J Ophthalmol 88:581-2. 2004
  75. ncbi Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure
    Elzbieta Polska
    Department of Clinical Pharmacology, Division of Ophthalmo Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 48:3768-74. 2007
    To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP).
  76. doi Efficacy and safety of tafluprost 0.0015% versus latanoprost 0.005% eye drops in open-angle glaucoma and ocular hypertension: 24-month results of a randomized, double-masked phase III study
    Hannu Uusitalo
    Department of Ophthalmology, Tampere University Hospital, University of Tampere, Tampere, Finland
    Acta Ophthalmol 88:12-9. 2010
    ..The objective of the study was to compare the long-term efficacy and safety of tafluprost 0.0015% with latanoprost 0.005% eye drops in patients with open-angle glaucoma or ocular hypertension...
  77. doi Tumor necrosis factor-alpha concentrations in the aqueous humor of patients with glaucoma
    Hideko Sawada
    Department of Ophthalmology, Niigata University School of Medicine, Asahimachi, Niigata, Japan
    Invest Ophthalmol Vis Sci 51:903-6. 2010
    To investigate the concentration of tumor necrosis factor (TNF)-alpha in the aqueous humor of patients with glaucoma, including correlations with glaucoma subtypes and intraocular pressure.
  78. pmc Defining "occludable" angles in population surveys: drainage angle width, peripheral anterior synechiae, and glaucomatous optic neuropathy in east Asian people
    P J Foster
    Singapore National Eye Centre and Singapore Eye Research Institute, Singapore
    Br J Ophthalmol 88:486-90. 2004
    ..The authors sought to assess the validity of this epidemiological classification by exploring the relation between drainage angle width, peripheral anterior synechiae (PAS) and glaucomatous optic neuropathy (GON)...
  79. pmc Extracellular matrix in the trabecular meshwork
    Ted S Acott
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger, Portland, OR 97239 4197, USA
    Exp Eye Res 86:543-61. 2008
    The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in regulating intraocular pressure (IOP) in both normal and glaucomatous eyes...
  80. pmc Anthropometric measures and their relation to incident primary open-angle glaucoma
    Louis R Pasquale
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 117:1521-9. 2010
    ..To assess the relation between anthropometric measures and incident primary open-angle glaucoma (POAG)...
  81. doi Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma
    John P Berdahl
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Ophthalmology 115:763-8. 2008
    ..To compare cerebrospinal fluid (CSF) pressure in patients with primary open-angle glaucoma (POAG) with that in nonglaucomatous patients...
  82. doi Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry
    David Touboul
    Department of Ophthalmology, Bordeaux 2 University, CHU Pellegrin, Place Amelie Raba Leon, Bordeaux, France
    J Cataract Refract Surg 34:616-22. 2008
    ..the correlation between corneal hysteresis (CH) measured with the Ocular Response Analyzer (ORA, Reichert) and ultrasonic corneal central thickness (CCT US) and intraocular pressure measured with Goldmann applanation tonometry (IOP GA).
  83. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
    ..Because of the robust protective effect, this treatment offers another tool for studying mechanisms of neuroprotection...
  84. ncbi Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study
    Kouros Nouri-Mahdavi
    Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles 90095, USA
    Ophthalmology 111:1627-35. 2004
    ..To investigate the risk factors associated with visual field (VF) progression in the Advanced Glaucoma Intervention Study (AGIS) with pointwise linear regression (PLR) analysis of serial VFs...
  85. ncbi The gradient of retinal functional changes during acute intraocular pressure elevation
    Bang V Bui
    Discoveries in Sight, Devers Eye Institute, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 46:202-13. 2005
    To characterize retinal function during a period of acutely elevated intraocular pressure (IOP) across a wide range of IOPs, including those typically observed in animals with experimental glaucoma.
  86. pmc Targeting amyloid-beta in glaucoma treatment
    Li Guo
    Glaucoma and Retinal Degeneration Research, University College London Institute of Ophthalmology, Bath Street, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 104:13444-9. 2007
    ..a major cause of irreversible blindness worldwide, previously associated simply with the effects of intraocular pressure. We show that Abeta colocalizes with apoptotic retinal ganglion cells (RGC) in experimental glaucoma and ..
  87. pmc Variability of intraocular pressure measurements in observation participants in the ocular hypertension treatment study
    Anjali M Bhorade
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ophthalmology 116:717-24. 2009
    To describe variability of intraocular pressure (IOP) measurements within the same eye and between right and left eyes over a 60-month period in participants in the Ocular Hypertension Treatment Study.
  88. pmc Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study
    Farnaz Memarzadeh
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 51:2872-7. 2010
    ..To examine the cross-sectional relationship between blood pressure, perfusion pressure, and prevalence of open angle glaucoma (OAG) in an adult Latino population...
  89. doi Intraocular pressure: modulation as treatment for glaucoma
    Joseph Caprioli
    Jules Stein Eye Institute, The David Geffen School of Medicine, Los Angeles, California, USA
    Am J Ophthalmol 152:340-344.e2. 2011
    To review the role of intervisit intraocular pressure (IOP) fluctuation as an independent risk factor for glaucoma.
  90. pmc Laser-induced ocular hypertension in albino CD-1 mice
    Christine T Fu
    Neuroscience Graduate Program, Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
    Invest Ophthalmol Vis Sci 51:980-90. 2010
    To establish a laser-induced model of ocular hypertension (LIOH) in albino CD-1 mice and to characterize the sequence of pathologic events triggered by intraocular pressure (IOP) elevation.
  91. pmc The path to open-angle glaucoma gene discovery: endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness
    Jac Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Invest Ophthalmol Vis Sci 51:3509-14. 2010
    ..Variance components modeling was used to determine the heritabilities of maximum intraocular pressure (IOP), maximum vertical cup-to-disc ratio (VCDR), and mean central corneal thickness (CCT)...
  92. doi Intraocular pressure and haemodynamic responses to insertion of the i-gel, laryngeal mask airway or endotracheal tube
    Salah A Ismail
    Department of Anaesthesia, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
    Eur J Anaesthesiol 28:443-8. 2011
    We hypothesised that the effects of insertion of an i-gel supraglottic airway management device on intraocular pressure (IOP) and haemodynamic variables would be milder than those associated with insertion of a laryngeal mask airway (LMA) ..
  93. doi Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis
    Javier Moreno-Montañés
    Department of Ophthalmology, Clinica Universidad de Navarra, Pamplona, Spain
    Invest Ophthalmol Vis Sci 51:335-43. 2010
    ..To compare the retinal nerve fiber layer (RNFL) evaluation using Cirrus optical coherence tomography (OCT) and Stratus OCT in glaucoma diagnosis...
  94. doi Cerebrospinal fluid pressure in ocular hypertension
    Ruojin Ren
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, China
    Acta Ophthalmol 89:e142-8. 2011
    To assess the lumbar cerebrospinal fluid pressure (CSF-P) in ocular hypertensive subjects with elevated intraocular pressure (IOP) but without development of glaucomatous optic nerve damage.
  95. doi Dynamics of retinal vessel response to flicker light in glaucoma patients and ocular hypertensives
    K Gugleta
    Ophthalmology Department, University Hospital Basel, Mittlerestr 91, CH 4031, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 250:589-94. 2012
    ..To analyze dynamics of retinal vessel dilation response to flicker light in patients with glaucoma and ocular hypertension...
  96. doi Comparison of Travoprost and Bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination
    Marco Centofanti
    Unità Dipartimentale Semplice di Glaucoma, University of Tor Vergata, Rome, Italy Istituto di Ricovero e Cura a Carattere Scientifico Fondazione G B Bietti, Rome, Italy
    Am J Ophthalmol 150:575-80. 2010
    ..bimatoprost plus timolol and travoprost plus timolol fixed combinations in glaucoma patients whose disease was controlled but had not reached their target intraocular pressure (IOP) with the fixed combination of latanoprost plus timolol.
  97. doi Randomized clinical trial of the efficacy and safety of preservative-free tafluprost and timolol in patients with open-angle glaucoma or ocular hypertension
    Almira Chabi
    Merck Sharp and Dohme Corp, PO Box 1000, North Wales, PA 19454 1099, USA
    Am J Ophthalmol 153:1187-96. 2012
    ..To compare the efficacy and safety of tafluprost, a preservative-free (PF) prostaglandin analogue, with PF timolol in patients with open-angle glaucoma or ocular hypertension...
  98. doi Initial parafoveal versus peripheral scotomas in glaucoma: risk factors and visual field characteristics
    Sung Chul Park
    Department of Ophthalmology, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA
    Ophthalmology 118:1782-9. 2011
    ..To assess risk factors for an initial parafoveal scotoma (IPFS) compared with an initial nasal step (INS) in glaucoma...
  99. doi Glial cell response and iNOS expression in the optic nerve head and retina of the rat following acute high IOP ischemia-reperfusion
    Kyong Jin Cho
    Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Brain Res 1403:67-77. 2011
    ..Activation of glial cells and the up-regulation of iNOS may contribute to the damage of the retina and optic nerve head of the rat following acute high IOP ischemia-reperfusion...
  100. doi A twenty-year follow-up study of trabeculectomy: risk factors and outcomes
    John Landers
    Department of Ophthalmology, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ophthalmology 119:694-702. 2012
    ..This study was undertaken to determine the performance of trabeculectomy surgery over a 20-year period and examine the associations between outcome and risk factors for trabeculectomy failure...
  101. doi Activated retinal glia mediated axon regeneration in experimental glaucoma
    Barbara Lorber
    Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Neurobiol Dis 45:243-52. 2012
    ..retinal ganglion cell axons after optic nerve crush was significantly increased in vivo when combined with intraocular pressure-induced experimental glaucoma...

Research Grants74

  1. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    ..the cytoskeleton compared to two major risk factors in glaucoma: age (DBA/2J mice) and exposure to elevated intraocular pressure (Microbead Occlusion Model)...
  2. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..One of the major risk factors of glaucoma is an elevated intraocular pressure (IOP), and the goal of glaucoma therapy is to lower IOP to safe levels...
  3. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..Elevated intraocular pressure (IOP) is a prominent risk factor as seen in primary open angle glaucoma (POAG)...
  4. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    ..Primary open-angle glaucoma (POAG), age-dependent and intraocular pressure (IOP)-related neurodegeneration of the optic nerve comprises 74% of all types of glaucoma...
  5. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2009
    ..exception is glaucoma, the most common optic neuropathy, where the most important risk factor is elevated intraocular pressure. Treatments for glaucoma, currently limited to drugs or surgery to lower intraocular pressure, are often ..
  6. Aqueous humor dynamics studies in vivo and in vitro
    PAUL LEON KAUFMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): New approaches to lower intraocular pressure, a significant risk factor for the progression of glaucoma, will be investigated...
  7. Forward Genetics to Identify Complex Gene Interactions Involved in Glaucoma
    Elena V Semina; Fiscal Year: 2010
    ..impairing diseases characterized by retinal ganglion cell death, and frequently associated with elevated intraocular pressure. Glaucoma is the second leading cause of blindness world-wide, with a prevalence of approximately 1...
  8. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2013
    ..not currently understood;however, the trabecular meshwork cells play a central role in the regulation of intraocular pressure in both the normal and disease state...
  9. Cellular Senescence and Glaucoma
    Pedro Gonzalez; Fiscal Year: 2011
    ..of miR-155, miR-204, and miR-29 in trabecular meshwork cells, as well as the evaluation of the effects in intraocular pressure induced by changes in expression of these microRNAs in living rats...
  10. Role of trabecular meshwork contractility in modulating outflow resistance
    CHEE HIAN TAN; Fiscal Year: 2013
    ..The present scientific focus is to seek to better understand a putative regulatory mechanism for intraocular pressure (IOP)...
  11. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
    This is a new R01 application to study the molecular events involved in intraocular pressure (IOP) regulation through adenosine-triphosphate-sensitive potassium (KATP) channels. Elevated IOP is the only treatable risk-factor for glaucoma...
  12. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..At each visit, patients underwent comprehensive testing including: multiple measures of intraocular pressure (Goldmann and Psacal), visual acuity, contrast sensitivity, ultrasonic corneal pachymetry of central ..
  13. Imaging retinal astrocytes, ganglion cells and axonal transport in vivo
    Brad Fortune; Fiscal Year: 2012
    ..pathophysiology of many ocular diseases by responding to a variety of insults such as ischemia, increased intraocular pressure and neuronal degeneration in a manner that has been characterized as gliosis...
  14. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..an interview and a comprehensive eye examination, including measurement of visual acuity, visual field, intraocular pressure, hemoglobin A1c, blood glucose, and serum C-reactive protein;additional tests will include optical ..
  15. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    ..oxidative damage to the trabecular meshwork (TM) cells, leading to decreased outflow facility and increased intraocular pressure. Although the evidence linking oxidative damage to glaucoma is strong, the causes of oxidative damage in ..
  16. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2012
    ..has focused on the molecular mechanism(s) by which laser trabeculoplasty (LTP) ameliorates the elevated intraocular pressure (IOP) associated with most of primary open-angle glaucoma...
  17. Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
    Douglas J Rhee; Fiscal Year: 2013
    ..Elevated intraocular pressure (IOP) is a causative risk factor and is due to altered drainage through the trabecular meshwork (TM)...
  18. Characterization of RGC death susceptibility alleles
    Robert W Nickells; Fiscal Year: 2013
    ..BALBRgcs1. We expect these mice to develop elevated intraocular pressure, and by virtue of carrying a susceptible Rgcs1 allele, a more severe form of glaucoma...
  19. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2012
    ..Our preliminary studies showed that retinal ischemia via elevated intraocular pressure (IOP) impaired bradykinin-induced NO-mediated dilation and enhanced ET-1-mediated constriction in pig ..
  20. Characterization of purified myocilin: glaucoma as a protein misfolding disease
    Raquel L Lieberman; Fiscal Year: 2013
    ..Eye drops, laser treatment, and/or surgery medically manage the symptom of increased intraocular pressure observed prior to retinal degeneration and loss of visual field, but do not constitute a therapy...
  21. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..Other therapeutic possibilities include pain management (chronic pain), glaucoma (lowering the intraocular pressure), and anxiety. The only formulation available in the United States is the soft gelatin oral capsule...
  22. Interleukin-6 and Retinal Ganglion Cell Degeneration in Glaucoma
    Rebecca M Sappington; Fiscal Year: 2013
    ..While age is the leading risk factor, elevated intraocular pressure (IOP) remains the primary treatable factor...
  23. STUDIES IN GLAUCOMATOUS OPTIC NERVE DAMAGE
    John C Morrison; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Understanding cellular mechanisms of axonal injury from elevated intraocular pressure (IOP) is essential for developing glaucoma treatments that will protect the optic nerve...
  24. Autophagic Lysosomal Pathway and Glaucoma
    PALOMA LITON; Fiscal Year: 2013
    ABSTRACT The fundamental abnormality occurring in the conventional outflow pathway associated with elevated intraocular pressure and therefore, increased risk of developing glaucoma, an age-related disease affecting more than 70 million ..
  25. Gene-Environment Interactions in Glaucoma
    LOUIS ROBERT PASQUALE; Fiscal Year: 2013
    Primary open-angle glaucoma (POAG) is an intraocular pressure (IOP)-dependent, slowly progressive optic neuropathy that ultimately leads to blindness...
  26. PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGE
    HARRY ALAN QUIGLEY; Fiscal Year: 2013
    ..seeks to develop new treatments for glaucoma based on the response of ocular tissues to the effects of intraocular pressure (IOP) related stress...
  27. Mitochondrial dysfunction in glaucomatous optic neuropathy
    Won Kyu Ju; Fiscal Year: 2013
    ..We have identified that elevated intraocular pressure (IOP) triggers excessive mitochondrial fission and cristae depletion, as well as OPA1 gene deficiency in ..
  28. Compartmentalized neurodegeneration of retinal ganglion cells in glaucoma
    Yvonne Ou; Fiscal Year: 2013
    ..This research examines the compartmentalized neurodegeneration of RGCs in response to elevated intraocular pressure, one of the main risk factors of glaucoma...
  29. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2009
    ..relevant for studies of glaucoma targeting aqueous outflow enhancement, (4) determine the mechanisms of intraocular pressure (IOP) reduction of other classes of potential glaucoma therapeutic agents (cannabinoids, nitric oxide ..
  30. NEURITIN:novel RGC neurotrophic factor and potential target for glaucoma therapy
    Donald J Zack; Fiscal Year: 2010
    ..ganglion cell (RGC) susceptibility to degeneration is modulated by the major risk factor, elevation of intraocular pressure (IOP), as well as other factors, will help in designing novel therapeutic approaches to complement IOP ..
  31. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    ..Primary open angle glaucoma (POAG), the most common form of glaucoma, is usually accompanied by elevated intraocular pressure (IOP) due to failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow...
  32. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In primary open-angle glaucoma (POAG), elevated intraocular pressure (IOP) is often attributed to diminished aqueous humor (AH) outflow facility caused by accumulation of extracellular matrix material ..
  33. Open Angle Glaucoma in Soluble Guanylate Cyclase Alpha 1 Deficient Mice
    Emmanuel S Buys; Fiscal Year: 2013
    ..Although several risk factors for OAG have been identified, including elevated intraocular pressure (IOP), the exact molecular mechanisms leading to OAG remain poorly understood...
  34. Glaucoma and Visual Function
    ANJALI MARUTI BHORADE; Fiscal Year: 2010
    ..As clinicians, we evaluate the progression of glaucoma using visual fields, intraocular pressure and optic disc appearance;however, the relationship between these measures and functional impairment is ..
  35. Extracelluar Matrix Organization and Biomechanics of the Lamina Cribrosa and Peri
    JONATHAN PIETER VANDE GEEST; Fiscal Year: 2013
    ..in populations of AD and HE compared with those of European Descent (ED), independent of the level of intraocular pressure. While the extracellular matrix microstructures of the LC and PS have been investigated previously, how ..
  36. Cellular Physiology of the Aqueous Outflow Pathway
    Haiyan Gong; Fiscal Year: 2013
    ..risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of the intraocular pressure (IOP), resulting from a rise in aqueous humor outflow resistance...
  37. African American Eye Disease Study
    Rohit Varma; Fiscal Year: 2013
    ..clinical trials have reported the benefits of tighter glycemic control on the development of DR, and lower intraocular pressure on the development and progression of glaucoma...
  38. Novel Therapy and Mechanisms in Glaucoma
    Tonia S Rex; Fiscal Year: 2013
    ..Current therapies are directed at lowering the intraocular pressure (IOP), the most significant risk factor for the development of glaucoma...
  39. Role of mechanosensation in retinal function and dysfunction
    David Krizaj; Fiscal Year: 2013
    ..S. There is substantial evidence that pathological mechanical stimulation mediated by an increase in intraocular pressure (IOP) plays a causal role in the etiology of glaucoma...
  40. MicroRNA-directed modulation of intraocular pressure
    Benjamin R tenOever; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lowering intraocular pressure (IOP) slows or stops the loss of vision in primary open-angle glaucoma (POAG) patients, including in those with normal IOP...
  41. External Glaucoma Drainage Device
    Bruce Klitzman; Fiscal Year: 2012
    ..Reduction of intraocular pressure (IOP) is the only proven treatment for delaying the progression of vision loss caused by glaucoma...
  42. Determining Molecular and Cellular Mechanisms of Glaucoma
    KAYARAT SAIDAS NAIR; Fiscal Year: 2013
    ..This results in inefficient aqueous humor exits, thereby causing high intraocular pressure (IOP) and glaucoma. The mechanisms underlying ACG are largely unidentified...
  43. Aqueous Humor Dynamic Components that Determine Intraocular Pressure Variance
    Sayoko E Moroi; Fiscal Year: 2013
    ....
  44. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2013
    ..is the second leading cause of blindness in the United States and is commonly associated with elevation of intraocular pressure (IOP) resulting from increased resistance to aqueous humor (AH) outflow through the trabecular meshwork (TM)..
  45. Enhanced Axon Sparing In Glaucoma Through Augmentation Of EphB/ephrin B Signaling
    David W Sretavan; Fiscal Year: 2013
    ..an estimated 100,000 patients each year lose some vision despite medical treatment for the normalization of intraocular pressure. As the incidence of glaucoma for the 65 yo...
  46. Oxidative Stress and Lysosomal Function in the Outflow Pathway
    PALOMA LITON; Fiscal Year: 2009
    Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the conventional outflow pathway to maintain normal levels of aqueous humor (AH) ..
  47. RETINAL GANGLION CELL AND AMACRINE CELL FUNCTION IN MOUSE MODELS OF ELEVATED INTR
    Benjamin J Frankfort; Fiscal Year: 2013
    ..My research project will focus on the effects of intraocular pressure (IOP) elevation in mice...
  48. Advanced Imaging for Glaucoma
    David Huang; Fiscal Year: 2012
    ..The impact of intraocular pressure on retinal blood flow and how flow affects the risk of glaucoma will also be studied...
  49. IRIS: Incorporating Research Into Sight
    Catherine Anne McCarty; Fiscal Year: 2013
    ..Aim 1 a. Develop and validate electronic algorithms for ocular hypertension/glaucoma, intraocular pressure (lOP) response to lOP lowering medications, AMD, response to AMD treatment, tear film insufficiency, ..
  50. Reverse Engineering of Trabecular Meshwork
    Nils A Loewen; Fiscal Year: 2013
    ..The ability to lower intraocular pressure by creating a new regulating barrier rather than surgically removing it (destroying the anterior chamber-..
  51. Genetics of Quantitative Traits Associated with Glaucoma
    John H Fingert; Fiscal Year: 2013
    ..b>Intraocular pressure is another crucial quantitative trait that is monitored in glaucoma patients...
  52. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy K Bhattacharya; Fiscal Year: 2013
    ..Thus, cochlin plays a key role in intraocular pressure (IOP) elevation...
  53. Control of Trabecular Meshwork Cytoskeleton
    Donna M Peters; Fiscal Year: 2011
    ..They are commonly associated with elevated levels of intraocular pressure (IOP) due to a reduction in aqueous humor outflow from the trabecular meshwork (TM)...
  54. Genetics of Diabetic Retinopathy in Hispanics
    Jerome I Rotter; Fiscal Year: 2011
    ..and clinical data and an eye examination that will include assessment of visual acuity, measurement of intraocular pressure, and obtaining standard 7-field fundus photographs...
  55. Glaucoma Pathogenesis of Oculocerebrorenal syndrome of Lowe
    Yang Sun; Fiscal Year: 2013
    ..Elevated intraocular pressure (IOP) has been known to be a strong risk factor and remains the only target for intervention, but the ..
  56. Early Detection of Glaucoma Using Raman Spectroscopy
    Tatjana Lazic; Fiscal Year: 2012
    ..and optic nerve tissue sections after induction of compressive optic neuropathy or acute elevation of intraocular pressure;4) A unique colony of dogs (Basset Hounds) with hereditary glaucoma has been developed, in which ..
  57. Trigeminal-autonomic relations in ocular homeostasis
    David A Bereiter; Fiscal Year: 2013
    ..Environmental challenges to the eye evoke diverse reflexes that maintain ocular blood flow, intraocular pressure, pupillary diameter and lacrimation...
  58. Rhythmic Stimulation as a Therapeutic Option for Injured Retinal Ganglion Cells
    Gustavo C Munguba; Fiscal Year: 2013
    ..6 million people throughout the world will have glaucoma by 2020. Currently, increased intraocular pressure is the only known modifiable risk factor in glaucoma pathophysiology, and therefore the only treatment ..
  59. The role of microglia in experimental glaucoma
    Monica L Vetter; Fiscal Year: 2013
    ..b>Intraocular pressure (IOP) elevation constitutes a risk factor in glaucoma, but is not sufficient to cause disease, suggesting ..
  60. Molecular mechanisms in steroid-induced glaucoma.
    John Danias; Fiscal Year: 2012
    Glucocorticosteroids are known to cause intraocular pressure (IOP) elevation in humans. This induced ocular hypertension can lead to glaucomatous visual loss...
  61. Caspase Activated Probes For In Vivo Optical Imaging of Retinal Neurodegeneration
    JAMES RUSSELL JOHNSON; Fiscal Year: 2012
    ..Glaucoma is usually associated with elevated intraocular pressure (lOP), but a subset of "normal tension glaucoma" patients develops damage without ever manifesting high ..
  62. To demonstrate the feasibility of a home tonometer to monitor IOP without contact
    JIM SON CHOU; Fiscal Year: 2010
    ..feasible, it will allow thousands of patients with progressive glaucomatous damage to keep track of their intraocular pressure (IOP) between office visits and to provide their physicians with a complete picture of their individual IOP ..
  63. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
    ..visual loss and blindness in glaucoma parents by: 1) identifying biochemical mediators of the reduction of intraocular pressure (IOP) produced by various modalities of glaucoma therapy; 2) developing new medications which optimize ..
  64. Telemetric Implantable Intraocular Pressure Sensor Syste
    LAWRENCE WAN; Fiscal Year: 2003
    ..technology does not allow for real-time, continuous (24/7, diurnal and nocturnal readings) monitoring of intraocular pressure (lOP) to enable physicians to study, diagnose and more clearly understand the response mechanism relating ..
  65. IN VIVO INHIBITORS OF OCULAR PROSTAGLANDIN SYNTHESIS
    STEVEN PODOS; Fiscal Year: 1980
    ..Arachidonic acid, a precursor of PGE2, elevates intraocular pressure and aqueous humor protein when applied topically...
  66. Sustained Drug Release for Antifibrosis
    Weiliam Chen; Fiscal Year: 2009
    ..Elevated intraocular pressure (IOP) is a significant risk factor for the development of glaucomatous optic neuropathy and visual field ..
  67. Real time imaging of the aqueous outflow pathway by two-photon endoscopy
    Hiroshi Nakamura; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): It is well known that the elevated intraocular pressure of primary open angle glaucoma is related to an increased resistance to the outflow of aqueous humor...
  68. A Potential Zebrafish Model of Glaucoma by Genetic Ablation and Modification of t
    Xinping Zhao; Fiscal Year: 2009
    ..physiological, and genetic conservation of the important eye tissues that play key roles in maintaining intraocular pressure (IOP) in zebrafish and humans strongly suggests that the fish is a promising model animal for studying ..
  69. DATA COORDINATING CENTER FOR EARLY GLAUCOMA TRIAL
    M Leske; Fiscal Year: 2004
    ..EMGT) is the first large randomized, controlled clinical trial to evaluate the effect of lowering the intraocular pressure (IOP) on the progression of newly detected open-angle glaucoma...
  70. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
    ..It involves death of retinal ganglion cells and degeneration of the optic nerve. High intraocular pressure (IOP) is frequently associated with glaucoma. It is thought to be an important causative factor...
  71. A Previously Unrecognized Site of Resistance in POAG
    Haiyan Gong; Fiscal Year: 2010
    ..We have found that acute elevation of intraocular pressure (IOP) in normal bovine and human eyes causes a decrease in the available area for aqueous outflow, Schlemm&..
  72. REGULATION OF TRABECULAR CELL GLYCOPROTEINS
    John Samples; Fiscal Year: 1991
    ..and juxtacanalicular cells secrete ECM components which are thought to impede outflow and maintain a normal intraocular pressure of approximately 7 mm above venous pressure...
  73. ANTERIOR CHAMBER FLUID ACETYLCHOLINE CONCENTRATION
    Jonathan Wirtschafter; Fiscal Year: 1980
    ..humor are little understood but may be important, particularly since cholinergic drugs are used to reduce intraocular pressure in glaucoma...
  74. MECHANISMS UNDERLYING THE CIRCADIAN RHYTHM OF IOP
    Douglas Gregory; Fiscal Year: 1999
    ..soluble guanylate cyclase, nitric oxide synthase modulation of cGMP in control of the circadian rhythms of intraocular pressure and the aqueous flow rate in rabbits and to explore the possible interaction between the sympathetic system ..