neurosecretion

Summary

Top Publications

  1. pmc The PC12 cell as model for neurosecretion
    R H S Westerink
    Cellular and Molecular Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Acta Physiol (Oxf) 192:273-85. 2008
  2. pmc The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells
    Jin Hua Tian
    Synaptic Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
    J Neurosci 25:10546-55. 2005
  3. ncbi A two-step model of secretion control in neuroendocrine cells
    C Heinemann
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Pflugers Arch 424:105-12. 1993
  4. pmc A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion
    Alexander M Walter
    Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam and VU University Medical Center, Amsterdam, The Netherlands Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS Comput Biol 9:e1003362. 2013
  5. ncbi Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion
    Nobutoshi C Harata
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA
    J Neurochem 97:1546-70. 2006
  6. ncbi In PC12 cells, expression of neurosecretion and neurite outgrowth are governed by the transcription repressor REST/NRSF
    Rosalba D'Alessandro
    Division of Neuroscience, IIT Network, Research Unit of Molecular Neuroscience, Vita Salute San Raffaele University and Scientific Institute San Raffaele, DIBIT, Via Olgettina 58, 20132 Milan, Italy
    Cell Mol Neurobiol 30:1295-302. 2010
  7. ncbi Munc18-1 as a key regulator of neurosecretion
    Gayoung A Han
    Division of Fundamental Neurobiology, University Health Network, Toronto, Ontario, Canada
    J Neurochem 115:1-10. 2010
  8. pmc Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells
    Cesar Mattei
    CNRS, Institut de Neurobiologie Alfred Fessard, Laboratoire de Neurobiologie Cellulaire et Moleculaire, Gif sur Yvette, France
    PLoS ONE 3:e3448. 2008
  9. ncbi Nicotinic acid adenine dinucleotide phosphate enhances quantal neurosecretion at the frog neuromuscular junction: possible action on synaptic vesicles in the releasable pool
    E Brailoiu
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614-1708, USA
    Mol Pharmacol 60:718-24. 2001
  10. ncbi Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans
    Tao Cai
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:3115-24. 2004

Detail Information

Publications197 found, 100 shown here

  1. pmc The PC12 cell as model for neurosecretion
    R H S Westerink
    Cellular and Molecular Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Acta Physiol (Oxf) 192:273-85. 2008
    ..As PC12 cells have some advantages over other models for neurosecretion, including chromaffin cells, it is more than likely that in the following decade PC12 cells will continue to ..
  2. pmc The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells
    Jin Hua Tian
    Synaptic Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
    J Neurosci 25:10546-55. 2005
    ..SNARE)-based fusion machinery is critical for understanding the mechanisms underlying calcium-dependent neurosecretion. Snapin binds to synaptosomal-associated protein 25 kDa (SNAP-25) and enhances the association of the SNARE ..
  3. ncbi A two-step model of secretion control in neuroendocrine cells
    C Heinemann
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Pflugers Arch 424:105-12. 1993
    ..Given these functional dependences a variety of results from the literature can be simulated. In particular, the model predicts the occurrence of secretory depression and augmentation under appropriate conditions...
  4. pmc A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion
    Alexander M Walter
    Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam and VU University Medical Center, Amsterdam, The Netherlands Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS Comput Biol 9:e1003362. 2013
    ....
  5. ncbi Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion
    Nobutoshi C Harata
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA
    J Neurochem 97:1546-70. 2006
    ..Full-collapse fusion and kiss-and-run will each contribute to maintaining cellular communication over a wide range of frequencies...
  6. ncbi In PC12 cells, expression of neurosecretion and neurite outgrowth are governed by the transcription repressor REST/NRSF
    Rosalba D'Alessandro
    Division of Neuroscience, IIT Network, Research Unit of Molecular Neuroscience, Vita Salute San Raffaele University and Scientific Institute San Raffaele, DIBIT, Via Olgettina 58, 20132 Milan, Italy
    Cell Mol Neurobiol 30:1295-302. 2010
    ..addition to the wild-type, low REST neurosecretory cells, it includes spontaneously defective clones lacking neurosecretion, where REST is as high as in non-nerve cells...
  7. ncbi Munc18-1 as a key regulator of neurosecretion
    Gayoung A Han
    Division of Fundamental Neurobiology, University Health Network, Toronto, Ontario, Canada
    J Neurochem 115:1-10. 2010
    Munc18-1 plays essential roles in neurosecretion by interacting with syntaxin-1 and controlling the formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex...
  8. pmc Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells
    Cesar Mattei
    CNRS, Institut de Neurobiologie Alfred Fessard, Laboratoire de Neurobiologie Cellulaire et Moleculaire, Gif sur Yvette, France
    PLoS ONE 3:e3448. 2008
    ..However, the mechanism through which slow Na+ influx promotes neurosecretion is not fully understood...
  9. ncbi Nicotinic acid adenine dinucleotide phosphate enhances quantal neurosecretion at the frog neuromuscular junction: possible action on synaptic vesicles in the releasable pool
    E Brailoiu
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614-1708, USA
    Mol Pharmacol 60:718-24. 2001
    ..1,4,5-trisphosphate (IP(3)) and cyclic adenosine diphosphate-ribose (cADPR) are second messengers that enhance neurosecretion by inducing Ca(2+) release from smooth endoplasmic reticulum (SER)...
  10. ncbi Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans
    Tao Cai
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:3115-24. 2004
    ..in the mouse results in reduced insulin release and additional phenotypes, consistent with a general effect on neurosecretion and hormone release...
  11. ncbi Localization of synaptic proteins involved in neurosecretion in different membrane microdomains
    Elena Taverna
    CNR Institute of Neuroscience, Department of Medical Pharmacology, University of Milan, Milan, Italy
    J Neurochem 100:664-77. 2007
    A number of proteins and signalling molecules modulate voltage-gated calcium channel activity and neurosecretion. As recent findings have indicated the presence of Ca(v)2...
  12. ncbi PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons
    Ke Ming Zhou
    Key Laboratory of Molecular Biophysics, Ministry of Education, and Joint Laboratory of Institute of Biophysics, Huazhong University of Science and Technology, Wuhan 430074, China
    Neuron 56:657-69. 2007
    ..Interestingly, the defect in DCV docking caused by UNC-31 mutation can be fully rescued by PKA activation. We also demonstrate that UNC-31 is required for UNC-13-mediated augmentation of DCV exocytosis...
  13. ncbi Nitric oxide implication in the control of neurosecretion by chromaffin cells
    M J Oset-Gasque
    Instituto de Bioquimica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    J Neurochem 63:1693-700. 1994
    ..These results suggest that NO could be an important intracellular messenger in the regulation of neurosecretion in chromaffin cells.
  14. ncbi How important are Rho GTPases in neurosecretion?
    Fanny Momboisse
    CNRS UPR 3212, Institut des Neurosciences Cellulaires et Integratives, Universite de Strasbourg, Strasbourg, France
    J Neurochem 117:623-31. 2011
    ..However, the role of Rho GTPases in neurosecretion is poorly documented...
  15. pmc Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2
    Tao Cai
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 5:e1000447. 2009
    ..To our knowledge, this is the first mutation identified that results in increased neurosecretion, a phenotype that has clinical implications for DCV-mediated secretory disorders.
  16. pmc Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis
    Frederic A Meunier
    Lincoln s Inn Fields Laboratories, London Research Institute, Cancer Research UK, London WC2A 3PX, United Kingdom
    Mol Biol Cell 16:4841-51. 2005
    ..Based on these results, we propose that production of PtdIns3P by PI3K-C2alpha is required for acquisition of fusion competence in neurosecretion.
  17. ncbi A neuroendocrine mechanism for sustaining fear
    Jay Schulkin
    Department of Physiology and Biophysics, Georgetown University, Washington, DC 20007, USA
    Trends Neurosci 28:629-35. 2005
    ..Central regulation of CRH by glucocorticoids is important for adaptive and sustained fear-related behaviors, and its aberration is associated with anxiety and depressive disorders...
  18. ncbi New insights on Saccus vasculosus evolution: a developmental and immunohistochemical study in elasmobranchs
    Catalina Sueiro
    Department of Cell Biology and Ecology, University of Santiago de Compostela, Santiago de Compostela, Spain
    Brain Behav Evol 70:187-204. 2007
    ..The existence of saccopetal monoaminergic and neurosecretory fibers reveals reciprocal connections between the SV and hypothalamic structures which have not been previously detected in teleosts...
  19. ncbi Squeeze involvement in the specification of Drosophila leucokinergic neurons: Different regulatory mechanisms endow the same neuropeptide selection
    Pilar Herrero
    Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Mech Dev 124:427-40. 2007
    ..Thus, Sqz appears to be a regulatory factor for neuropeptidergic identity common to all leucokinergic cells, whose function in different cell types is regulated by cell-specific factors...
  20. ncbi Interactions of temperature and angiotensin II in paraventricular neurons of rats in vitro
    Mathias Dewald
    Institut fur Normale und Pathologische Physiologie, Deutschhausstrasse 2, 35037 Marburg, Germany
    Pflugers Arch 444:117-25. 2002
    ....
  21. ncbi Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
    Kristin Tessmar-Raible
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
    Cell 129:1389-400. 2007
    ....
  22. pmc Exon expression profiling reveals stimulus-mediated exon use in neural cells
    Adrienne E McKee
    Department of Systems Biology, 200 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Biol 8:R159. 2007
    ..Although calcium-induced transcription and transcript variation have both been recognized as important sources of gene regulation, the interplay between these two phenomena has not been evaluated on a genome-wide scale...
  23. ncbi Synergistic activation of astrocytes by ATP and norepinephrine in the rat supraoptic nucleus
    J Espallergues
    INSERM U710, University of Montpellier II, 34095 Montpellier Cedex 9, France
    Neuroscience 148:712-23. 2007
    ....
  24. ncbi Synapsin II negatively regulates catecholamine release
    Melissa Villanueva
    Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Cell Biol 35:125-36. 2006
    ....
  25. ncbi Beacon-like immunoreactivity in the hypothalamus of Sprague-Dawley rats
    G Cristina Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577 Johnson City, TN 37614, USA
    Neurosci Lett 317:166-8. 2002
    ....
  26. ncbi The morphological and histochemical neurosecretory magnocellular system in the rat after administration of chlorpromazine
    Ewa Arciszewska
    Department of Histology and Embryology, Medical University, Białystok, Poland
    Folia Morphol (Warsz) 63:83-5. 2004
    ..It was found that CPZ reduced the content of the neurosecretory material after 24 h, while an increase was observed 7 days after the last drug administration...
  27. ncbi Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models
    Jie Pan
    Department of Paediatric Laboratory Medicine and Programme in Structural Biology and Biochemistry, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Respir Cell Mol Biol 27:553-60. 2002
    ..We propose that these tumor cell lines may be useful models for investigating the role of CFTR in PNEC/NEB functions in health and disease...
  28. ncbi Fish caudal neurosecretory system: a model for the study of neuroendocrine secretion
    Catherine R McCrohan
    Faculty of Life Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Gen Comp Endocrinol 153:243-50. 2007
    ..Furthermore, the presence of homologues of urotensins throughout the vertebrates has sparked new interest in these peptides and their functional evolution...
  29. ncbi Mechanism of alpha-latrotoxin action at nerve endings of neurohypophysis
    Michael Hlubek
    Department of Molecular and Integrative Physiology, 7807 Medical Sciences II Building, University of Michigan, Ann Arbor, MI 48109 0622, USA
    Brain Res 992:30-42. 2003
    ..While alpha-latrotoxin mobilizes intracellular Ca(2+) stores the elevation in [Ca(2+)] reached is insufficient to trigger measurable exocytosis...
  30. ncbi Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23
    Jakob B Sørensen
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Cell 114:75-86. 2003
    ..We conclude that three alternative SNARE components support exocytosis, but they differ in their ability to stabilize vesicles in the primed state...
  31. ncbi Neuroendocrine facets of human puberty
    Johannes D Veldhuis
    University of Virginia School of Medicine, Charlottesville, USA
    Neurobiol Aging 24:S93-S119; discussion S121-2. 2003
    ..Most notably, the outflow of gonadotropins and growth hormone (GH) proceeds both independently and jointly. The current update highlights this unique dependency in the human...
  32. ncbi Regulation of cyclic adenosine 3',5'-monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing hormone neurons
    Carlos E Navarro
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 17:1792-804. 2003
    ..These findings indicate that occupancy of the plasma membrane-associated ERs expressed in GT1-7 neurons by physiological estradiol levels causes activation of a Gi protein and modulates cAMP signaling and neuropeptide secretion...
  33. ncbi Gonadotropin-releasing hormone (GnRH) receptor expression and membrane signaling in early embryonic GnRH neurons: role in pulsatile neurosecretion
    Antonio J Martinez-Fuentes
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Mol Endocrinol 18:1808-17. 2004
    ....
  34. ncbi Neuroendocrine stress response in patients undergoing benign ovarian cyst surgery by laparoscopy, minilaparotomy, and laparotomy
    Elisabetta Marana
    Department of Anesthesiology, Intensive Care, and Emergency Medicine, Catholic University of the Sacred Heart, Largo Agostino Gemelli no 8, Rome, Italy
    J Am Assoc Gynecol Laparosc 10:159-65. 2003
    ..To quantify and compare neuroendocrine stress responses during and immediately after surgery by laparoscopy, minilaparotomy, and laparotomy for benign ovarian cysts...
  35. ncbi The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype
    Alexander W Bruce
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    J Neurochem 98:1828-40. 2006
    ..This is the first demonstration of a transcription factor that directly controls expression of many major components of the RSP and provides further insight into the function of REST...
  36. ncbi Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells
    Y Peng Loh
    Section on Cellular Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    J Mol Neurosci 22:63-71. 2004
    ..These results support the model that POMC is actively sorted to the RSP granules for processing and secretion by a sorting signal-mediated mechanism...
  37. ncbi Calcium requirements for exocytosis do not delimit the releasable neuropeptide pool
    Xinghua Lu
    Department of Pharmacology, E1351 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Calcium 33:267-71. 2003
    ....
  38. ncbi [Morphofunctional basis of neurosecretory cell plasticity]
    P E Garlov
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 44:747-67. 2002
    ....
  39. ncbi The polybasic sequence in the C2B domain of rabphilin is required for the vesicle docking step in PC12 cells
    Takashi Tsuboi
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama, Japan
    J Neurochem 100:770-9. 2007
    ..These results indicate that the polybasic sequence in the C2B domain functions as an effector domain for SNAP-25 and controls the number of 'releasable' vesicles docked to the plasma membrane...
  40. ncbi A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells
    Alena Pance
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    J Neurochem 99:1435-44. 2006
    ..Hence, A35C may provide clues about the mechanisms that underlie control of neurosecretion. We used mRNA microarray profiling to examine gene expression in A35C...
  41. ncbi Postnatal development of catecholamine inputs to the paraventricular nucleus of the hypothalamus in rats
    L Rinaman
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 438:411-22. 2001
    ....
  42. ncbi Extrasynaptic release of dopamine in a retinal neuron: activity dependence and transmitter modulation
    M Puopolo
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 30:211-25. 2001
    ..Since the somatic receptors for these ligands are extrasynaptic, we suggest that the composition of the extracellular fluid directly modulates extrasynaptic release...
  43. ncbi Neuroendocrine secretory protein 55 (NESP55) in the spinal cord of rat: an immunocytochemical study
    Yongling Li
    Department of Anatomy and Cell Biology, Institute of Biomedicine, Goteborg University, SE 405 30 Goteborg, Sweden
    J Comp Neurol 506:733-44. 2008
    ....
  44. ncbi Butyrate sensitizes the release of substance P and calcitonin gene-related peptide evoked by capsaicin from primary cultured rat dorsal root ganglion neurons
    Yi Xing
    Department of Anatomy, Shandong University School of Medicine, Jinan 250012, China
    Neuro Endocrinol Lett 27:695-701. 2006
    ..To investigate whether butyrate increases substance P (SP) and calcitonin gene-related peptide (CGRP) release evoked by capsaicin from primary cultured dorsal root ganglion (DRG) neurons...
  45. ncbi Plasticity of nonapeptidergic neurosecretory cells in fish hypothalamus and neurohypophysis
    Pavel Evgenyevich Garlov
    Institute of Cytology, Russian Academy of Science, St Petersburg 194064, Russia
    Int Rev Cytol 245:123-70. 2005
    ..In the latter, the key role is probably played by the Golgi complex...
  46. ncbi Circadian regulation of the lark RNA-binding protein within identifiable neurosecretory cells
    X Zhang
    Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    J Neurobiol 45:14-29. 2000
    ....
  47. ncbi Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion
    Luca Grumolato
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA CNRS, University of Rouen 76821 Mont St Aignan, France
    FASEB J 22:1756-68. 2008
    ..These findings demonstrate the implication of a selenoprotein in the regulation of Ca(2+) homeostasis and neuroendocrine secretion in response to a cAMP-stimulating trophic factor...
  48. ncbi Expression of the neurosecretory process in PC12 cells is governed by REST
    Rosalba D'Alessandro
    Vita Salute San Raffaele University, Center of Excellence in Cell Development, Milan, Italy
    J Neurochem 105:1369-83. 2008
    ..Our results identify REST, working by direct and indirect mechanisms, as the factor governing the maintenance of the neurosecretory process and the properties of dense-core vesicles in PC12 cells...
  49. ncbi Contributions of insect research toward our understanding of neurosecretion
    Marc J Klowden
    Division of Entomology, University of Idaho, Moscow 83844, USA
    Arch Insect Biochem Physiol 53:101-14. 2003
    The process of neurosecretion is an important and widespread method of biological communication among animals...
  50. ncbi Role of biogenic amines and cHH in the crustacean hyperglycemic stress response
    Simonetta Lorenzon
    BRAIN Center, Department of Biology, University of Trieste, via Giorgieri 7, I 34127 Trieste, Italy
    J Exp Biol 208:3341-7. 2005
    ..The fact that copper induced a rapid and massive release of 5-HT from the eyestalk can explain its demonstrated role in inducing the release of cHH and the consequent hyperglycemia in intact but not eyestalkless animals...
  51. ncbi Secrets of the secretory pathway in dendrite growth
    Michael D Ehlers
    Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 55:686-9. 2007
    ..Dendrites and axons exhibit different morphologies and patterns of growth. This difference in neuronal structure is controlled by evolutionarily conserved directed trafficking through the secretory pathway...
  52. pmc Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion
    M Sjöblom
    Department of Physiology, Uppsala University, Uppsala, Sweden
    J Clin Invest 108:625-33. 2001
    ..Thus, melatonin stimulates duodenal bicarbonate secretion via action at enterocyte MT2-receptors and mediates neural stimulation of the secretion...
  53. ncbi Synthesis of the porcine LH- and FSH-releasing hormone by the solid-phase method
    H Matsuo
    Biochem Biophys Res Commun 45:822-7. 1971
  54. ncbi The destination of the aged, nonreleasable neurohypophyseal peptides stored in the neural lobe is associated to the remodeling of the neurosecretory axon
    Juan Krsulovic
    Instituto de Histologia y Patologia, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile
    Microsc Res Tech 68:347-59. 2005
    ..No differences were detected at the neural lobe level between normal and mutant rats subjected to the same experimental conditions...
  55. ncbi The pharmacological treatment of heart failure: are we looking at the sunset of the neurohormonal hypothesis
    Maurizio Porcu
    Ital Heart J 3:437-8. 2002
  56. pmc Calmodulin increases transmitter release by mobilizing quanta at the frog motor nerve terminal
    Eugen Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, TN 37614 1708, USA
    Br J Pharmacol 137:719-27. 2002
    ..The decreases in MEPP size and m produced by W7 were both reversed by addition of CaM. Our results suggest that CaM increases transmitter release by mobilizing synaptic vesicles at the frog motor nerve terminal...
  57. ncbi Clinical and molecular evidence of abnormal processing and trafficking of the vasopressin preprohormone in a large kindred with familial neurohypophyseal diabetes insipidus due to a signal peptide mutation
    C Siggaard
    Department of Pediatrics, Aarhus University Hospital
    J Clin Endocrinol Metab 84:2933-41. 1999
    ..diabetes insipidus (adFNDI) is a rare disease characterized by postnatal onset of polyuria and a deficient neurosecretion of the antidiuretic hormone, arginine vasopressin (AVP)...
  58. ncbi Effects of reducing agents on glutathione metabolism and the function of carotid body chemoreceptor cells
    Constancio Gonzalez
    Departamento de Bioquimica y Biologia Molecular y Fisiologia, Facultad de Medicina, Universidad de Valladolid, E 47005 Valladolid, Spain
    Biol Chem 385:265-74. 2004
    ..found that hypoxia does not alter the glutathione reduction potential but that it activates chemoreceptor cell neurosecretion. Incubation of tissues with reduced glutathione increases the glutathione-reducing potential but does not ..
  59. ncbi New concepts of the neuroendocrine regulation of gonadotropin surges in rats
    J E Levine
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 56:293-302. 1997
    ..that ovulate spontaneously, two key events mediate the stimulation of preovulatory gonadotropin surges: 1) neurosecretion of a preovulatory LHRH surge and 2) an acute increase in responsiveness of the pituitary gland to the LHRH ..
  60. ncbi Experimental uremia affects hypothalamic amino acid neurotransmitter milieu
    F Schaefer
    Division of Paediatric Nephrology, University Children s Hospital, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 12:1218-27. 2001
    ..The mechanisms of neurosecretion were evaluated further by inhibition of vesicular release with the use of Ca(2+)-free, Mg(2+)-enriched ..
  61. ncbi Pulsatile release of luteinizing hormone-releasing hormone (LHRH) in cultured LHRH neurons derived from the embryonic olfactory placode of the rhesus monkey
    E Terasawa
    Wisconsin Regional Primate Research Center, and Department of Pediatrics, University of Wisconsin, Madison 53715 1299, USA
    Endocrinology 140:1432-41. 1999
    ..These results indicate that: 1) the presence of extracellular Ca2+ is essential for LHRH neurosecretion; 2) Ca2+ enters the cell via L-type channels but not N-type channels; and 3) mobilization of intracellular Ca2+..
  62. ncbi A two-cell biosensor that couples neuronal cells to optically monitored fish chromatophores
    R R Preston
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Biosens Bioelectron 16:447-55. 2001
    ..Agents known to stimulate catecholamine neurosecretion (secretagogues) were presented to the PC12 cells...
  63. ncbi Translating blood-borne stimuli: chemotransduction in the carotid body
    Prem Kumar
    Department of Physiology, The Medical School, University of Birmingham, Birmingham, UK
    Sheng Li Xue Bao 59:128-32. 2007
    ..and the resultant membrane depolarisation is sufficient to activate voltage-gated Ca(2+) entry leading to neurosecretion and afferent discharge...
  64. pmc Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings
    Jody K Hirsh
    Department of Molecular Pharmacology and Biological Chemistry S 215, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Physiol 545:337-43. 2002
    ..GTP-binding protein attached to synaptic vesicles, has been implicated in several stages in the process of neurosecretion, including a late stage occurring just prior to the actual release of neurotransmitter...
  65. ncbi The Coffin-Lowry syndrome-associated protein RSK2 and neurosecretion
    M Zeniou-Meyer
    Département Neurotransmission and Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Intégratives UPR 3212, Centre National de Recherche Scientifique and Université de Strasbourg, 5 rue Blaise Pascal, 67084 Strasbourg, France
    Cell Mol Neurobiol 30:1401-6. 2010
    ..no obvious brain abnormalities at the anatomical and histological levels to study the function of RSK2 in neurosecretion. Behavioral studies revealed normal motor coordination, but a profound retardation in spatial learning and a ..
  66. ncbi The multiple actions of black widow spider toxins and their selective use in neurosecretion studies
    Y A Ushkaryov
    Department of Biological Sciences, Imperial College, London, SW7 2AY, UK
    Toxicon 43:527-42. 2004
    ..As a result, important insights have been gained into the receptor signalling and the role of intracellular Ca(2+) stores in the effect of alphaLTX...
  67. ncbi Effect of CO on VO2 of carotid body and chemoreception with and without Ca2+
    S Lahiri
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Auton Nerv Syst 66:1-6. 1997
    ..Lahiri, News Physiol. Sci. 9 (1992) 161-165], Ca2+ effects occur at the level of neurosecretion after the level of oxygen consumption, according to the following scheme: CO-hypoxia-->VO2 decrease-->K+ ..
  68. pmc Flufenamic acid modulates multiple currents in gonadotropin-releasing hormone neurons
    Yong Wang
    Department of Biological Engineering, University of Missouri, Dalton Cardiovascular Research Center, Columbia, MO 65211, USA
    Brain Res 1353:94-105. 2010
    Reproduction in mammals is dependent upon the appropriate neurosecretion of gonadotropin-releasing hormone (GnRH), yet the endogenous generation of activity underlying GnRH secretion remains poorly understood...
  69. ncbi Clinically non-functioning pituitary macroadenomas in the elderly
    Patrizia Del Monte
    Division of Endocrinology, Galliera Hospital, Mura delle Cappuccine 14, 16128 Genova, Italy
    Aging Clin Exp Res 19:34-40. 2007
    ..The aim of the present study was to evaluate the clinical presentation, characteristics and post-surgical outcome of non-functioning pituitary macroadenomas (NFPM) in elderly patients...
  70. ncbi N type Ca2+ channels and RIM scaffold protein covary at the presynaptic transmitter release face but are components of independent protein complexes
    R Khanna
    Cellular and Molecular Biology Division, MP14 320 Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario, M5T 2S8 Canada
    Neuroscience 140:1201-8. 2006
    ..2) calcium channels. Thus, neurosecretion involves two key processes: the docking of vesicles at the transmitter release site, a process that involves ..
  71. ncbi Substance P enhances desensitization of the nicotinic response in bovine chromaffin cells but enhances secretion upon removal
    L K Lyford
    Program in Molecular and Cellular Biology, University of Massachusetts, Amherst 01003
    J Neurochem 55:1960-5. 1990
    A fundamental process in neurosecretion is desensitization, or a declining response to a stimulus. The response of chromaffin cells to continuous nicotinic stimulation, secretion of catecholamines, desensitizes within a few minutes...
  72. ncbi Regulation of hypothalamic gonadotropin-releasing hormone secretion in experimental uremia: in vitro studies
    S Wibullaksanakul
    Department of Obstetrics and Gynecology, University of Sydney, Australia
    Neuroendocrinology 54:353-8. 1991
    ..GnRH release and the function of GnRH-secreting neurons have suggested functional disturbances of GnRH neurosecretion; however, the precise biochemical mechanisms involved were not defined...
  73. ncbi Intracellular interaction between syntaxin and Munc 18-1 revealed by fluorescence resonance energy transfer
    Adinarayanareddy Yerrapureddy
    Department of Immunology and Molecular Biology, Veterinary Faculty, Free University, Berlin
    Mol Membr Biol 22:401-10. 2005
    b>Neurosecretion is catalyzed by assembly of a soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE)-complex composed of SNAP-25, synaptobrevin and syntaxin. Munc 18-1 is known to bind to syntaxin in vitro...
  74. ncbi Clocks and the black box: circadian influences on gonadotropin-releasing hormone secretion
    P E Chappell
    Department of Reproductive Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0674, USA
    J Neuroendocrinol 17:119-30. 2005
    ..This review re-examines multiple models of circadian control of reproductive neurosecretion, armed with the recent characterisation of the intracellular transcriptional feedback loops that comprise the ..
  75. pmc Suppression of Ca2+ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells
    Jason J Lefkowitz
    Department of Physiology, University of Massachusetts Medical School, Worcester, 01655, USA
    J Gen Physiol 134:267-80. 2009
    A central concept in the physiology of neurosecretion is that a rise in cytosolic [Ca(2+)] in the vicinity of plasmalemmal Ca(2+) channels due to Ca(2+) influx elicits exocytosis...
  76. ncbi Oxytocin neuron activation in NCAM-deficient mice: anatomical and functional consequences
    D T Theodosis
    Laboratory of Morphofunctional Neurobiology, INSERM U 378, University Victor Segalen, 733770 Bordeaux, France
    Eur J Neurosci 20:3270-80. 2004
    During stimulated neurosecretion in the rat, oxytocin neurons display a reduced glial coverage and receive an increased number of synapses, changes that are reversed on arrest of stimulation...
  77. ncbi Blockade of growth hormone-releasing factor (GRF) activity in the pituitary and hypothalamus of the conscious rat with a peptidic GRF antagonist
    M D Lumpkin
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, D C 20007
    Endocrinology 124:1522-31. 1989
    ..possibly representing a negative ultrashort loop autoregulation of GRF and/or stimulation of somatostatin neurosecretion. To demonstrate that such neuromodulation acts physiologically through endogenous GRF activity, the peptidic ..
  78. ncbi The proteins of synaptic vesicle membranes are affected during ageing of rat brain
    S R Lee
    Department of Biochemistry, College of Medicine, Hallym University, Chunchon, Kangwon Do, Korea
    Exp Mol Med 33:220-5. 2001
    ..In this study, we have examined the regulation of small GTP-binding proteins that are implicated in neurosecretion and differentiation of neuron during ageing processes...
  79. ncbi "Low" concentrations of sodium fluoride inhibit neurotransmitter release from the guinea-pig superior cervical ganglion
    Pier Giorgio Borasio
    Department of Biology, Section of General Physiology, University of Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
    Neurosci Lett 364:86-9. 2004
    ..Thus a NaF-sensitive G protein, linked to cAMP synthesis, is determinant for the inhibition of neurosecretion in this cholinergic synapse, involving Ca2+-dependent mechanisms.
  80. ncbi Expression of dense-core vesicles and of their exocytosis are governed by the repressive transcription factor NRSF/REST
    Rosalba D'Alessandro
    Vita Salute San Raffaele University, Milan, Italy
    Ann N Y Acad Sci 1152:194-200. 2009
    ..In wild-type PC12 fully competent for neurosecretion, NRSF/REST is low...
  81. ncbi Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release
    P Foran
    Department of Biochemistry, Imperial College, London, UK
    Biochemistry 35:2630-6. 1996
    The seven types (A--G) of botulinum neurotoxin (BoNT) are Zn2+ -dependent endoproteases that potently block neurosecretion. Syntaxin is presently thought to be the sole substrate for BoNT/C1, and synaptosomal-associated protein of Mr = 25 ..
  82. ncbi Purinergic signalling: past, present and future
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Braz J Med Biol Res 42:3-8. 2009
    ..Both short-term purinergic signalling in neurotransmission, neuromodulation and neurosecretion and long-term (trophic) purinergic signalling of cell proliferation, differentiation, motility, death in ..
  83. pmc A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan
    Brian H Lee
    Department of Physiology, University of California San Francisco, San Francisco, CA, USA
    PLoS Genet 4:e1000213. 2008
    ....
  84. ncbi Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells
    Yaara Kapp-Barnea
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Immunol 171:5320-7. 2003
    ..This protein has been implicated in the control of neurosecretion from dense core granules in neuronal cells as well as in the control of constitutive secretory pathways in ..
  85. ncbi alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor
    V G Krasnoperov
    Department of Environmental Medicine, New York University Medical Center, New York 10016, USA
    Neuron 18:925-37. 1997
    alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors...
  86. ncbi Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells
    Folker Spitzenberger
    Experimental Diabetology and the Department of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, 01307 Dresden, Germany
    J Biol Chem 278:26166-73. 2003
    ..Involvement of ICA69 in neurosecretion has been suggested by the impairment of acetylcholine release at neuromuscular junctions upon mutation of its ..
  87. ncbi Synaptobrevin 2 is palmitoylated in synaptic vesicles prepared from adult, but not from embryonic brain
    M Veit
    Department of Immunology and Molecular Biology, Free University, Berlin, Germany
    Mol Cell Neurosci 15:408-16. 2000
    Neuronal SNARE-proteins such as synaptobrevin, SNAP 25, and synaptotagmin are key players during neurosecretion. So far palmitoylation of SNAP-25 and synaptotagmin 1 have been described in vivo...
  88. pmc Secretory vesicle rebound hyperacidification and increased quantal size resulting from prolonged methamphetamine exposure
    Dmitriy Markov
    Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Neurochem 107:1709-21. 2008
    ..on secretory vesicle pH, and amperometry and intracellular patch electrochemistry to observe the effects on neurosecretion and cytosolic catecholamines in cultured rat chromaffin cells...
  89. ncbi A review of the role of neurosecretion in the control of juvenile hormone synthesis: a tribute to Berta Scharrer
    B Stay
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Insect Biochem Mol Biol 30:653-62. 2000
    ..For the latter group, the neuropeptide regulators of the corpora allata have yet to be isolated. The families of neurosecretory regulators will continue to grow...
  90. pmc Identifying the stress transcriptome in the adrenal medulla following acute and repeated immobilization
    Xiaoping Liu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Ann N Y Acad Sci 1148:1-28. 2008
    ..Robust changes were also observed in transcripts related to growth factors, apoptosis, neurosecretion/neuropeptides, heat shock proteins, structural proteins, chemokines, cytokines, metabolism/lipid-metabolism, ..
  91. ncbi Neuronal Ca2+ sensor 1, the mammalian homologue of frequenin, is expressed in chromaffin and PC12 cells and regulates neurosecretion from dense-core granules
    B W McFerran
    The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
    J Biol Chem 273:22768-72. 1998
    ..No effect of overexpression was seen on GH release because of Ca2+ in permeabilized cells suggesting that NCS-1 may have a regulatory but not direct role in neurosecretion.
  92. ncbi Presence of paraneuronal pseudobranchial neurosecretory system in the gill region of two air-breathing clupeids, Notopterus chitala and Notopterus notopterus
    A Gopesh
    Department of Zoology, University of Allahabad, Allahabad 211002, U P, India
    Respir Physiol Neurobiol 171:135-43. 2010
    The pseudobranchial neurosecretory system (PNS) is a system of neurosecretion observed in certain groups of teleosts, which are air-breathing or known to tolerate low oxygen tension in the surrounding water...
  93. ncbi A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells
    Romana Tomasoni
    Division of Immunology, Transplantation Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Cell Sci 124:3174-86. 2011
    ..Upregulation of REST promoted proliferation and phenotypic changes, thus hindering neurosecretion. The new REST-TSC2-β-catenin signaling paradigm might have an important role in various aspects of neural ..
  94. ncbi [Modulating effect of anticonvulsive agents on Ca2+ dependent membrane fusion in cell-free model of neurosecretion]
    I O Trykash
    Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv
    Ukr Biokhim Zh 75:81-6. 2003
    ..Ethosuximide- and sodium valproat-provoked fusion of synaptic vesicles and plasma membranes of synaptosomes were suppressed by convulsant drugs pentylenetetrazol and picrotoxin...
  95. ncbi Behavioral evaluation of GH treatment in short statured children and adolescents: findings from a pilot study
    H C Steinhausen
    Department of Child and Adolescent Psychiatry, University of Zurich, Switzerland
    J Endocrinol Invest 25:351-6. 2002
    ..The behavioral changes over time were independent of diagnostic category, gender, height velocity, puberty and age...
  96. ncbi SNAP-25 traffics to the plasma membrane by a syntaxin-independent mechanism
    Stephanie S Loranger
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    J Biol Chem 277:34303-9. 2002
    ..targets efficiently to the plasma membrane in cells of neuronal origin but only partially in HeLa cells, a neurosecretion-incompetent line. This phenotype was not rescued when syntaxin 1A was co-expressed with SNAP-25...
  97. ncbi Adequate stimuli of the carotid body: more than an oxygen sensor?
    Prem Kumar
    Department of Physiology, The Medical School, University of Birmingham, Birmingham, UK
    Respir Physiol Neurobiol 157:12-21. 2007
    ..process, albeit converging at the point of type I cell membrane depolarisation or Ca(2+) -dependent neurosecretion. We suggest, therefore, that the carotid body might better be viewed as a polymodal receptor with its multiple ..
  98. ncbi Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta
    Anja van de Stolpe
    Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Mol Endocrinol 18:2908-23. 2004
    ....
  99. pmc Storage and secretion of beta-NAD, ATP and dopamine in NGF-differentiated rat pheochromocytoma PC12 cells
    Ilia A Yamboliev
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Eur J Neurosci 30:756-68. 2009
    ..Adrenal chromaffin cells are thus used here as a single-cell model to examine mechanisms of concomitant neurosecretion. Using high-performance liquid chromatography techniques with electrochemical and fluorescence detection we ..
  100. ncbi Fusion of synaptic vesicles and plasma membrane in the presence of synaptosomal soluble proteins
    I O Trikash
    Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Leontovich st 9, 01601 Kiev, Ukraine
    Neurochem Int 49:270-5. 2006
    ..between synaptic vesicles and plasma membranes isolated from rat brain synaptosomes is regarded as a model of neurosecretion. The main aim of current study is to investigate whether the synaptosomal soluble proteins are essential ..
  101. ncbi Oxygen sensing in neuroepithelial and adrenal chromaffin cells
    C A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Novartis Found Symp 272:106-14; discussion 114-8, 131-40. 2006
    ..membrane-bound NADPH oxidase which during hypoxia, signals K+ channel inhibition, membrane depolarization and neurosecretion via changes in reactive oxygen species (ROS) (e.g. H2O2)...

Research Grants62

  1. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..investigations have the potential to significantly change our understanding of the mechanisms that control neurosecretion and the mechanisms of antidepressants and other drugs that target SERT...
  2. Estrogen Modulation of Bursting Activity in GnRH Neurons
    Oline K Ronnekleiv; Fiscal Year: 2013
    ..by which the ovarian steroid 17 - estradiol (E2) regulates GnRH neuronal excitability, which controls GnRH neurosecretion and fertility...
  3. Circadian Regulation of Gonadotropin-Releasing Hormone
    Patrick E Chappell; Fiscal Year: 2010
    ..Additionally, these studies provide insight into broader mechanisms of endocrine neurosecretion, and advance circadian biology by exploring how transcriptional oscillations can control synchronous multi-..
  4. Dynamic Interactions Between G Proteins and Calcium at SNARE Complexes
    Simon T Alford; Fiscal Year: 2013
    ..on direct mechanisms by which G?? inhibits transmitter release and have demonstrated that G?? can inhibit neurosecretion by an interaction with the fusion machinery - the SNARE complex...
  5. Regulation of opioid receptor function in trigeminal ganglion
    William P Clarke; Fiscal Year: 2012
    ..The neurosecretion study of Drosophila as a model system provides extraordinary opportunities to use different methods of gene ..
  6. Mechanisms of fusion and transmitter release in neurosecretion
    Manfred Lindau; Fiscal Year: 2012
    ..This process of neurosecretion is of outstanding importance in a broad range of physiological functions in the human body...
  7. Sex Steroids, Kisspeptin and Regulation of GnRH
    Sally Radovick; Fiscal Year: 2013
    ..cell-specific ERa knockout (KERaKO) mice to treatments that evoke negative and positive feedback actions on LH neurosecretion will be assessed using a newly developed microdialysis system...
  8. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    EI TERASAWAGRILLEY; Fiscal Year: 2011
    ..Two specific aims are proposed. The first aim will test the hypothesis that LHRH neurosecretion occurs as a consequence of synchronized neuronal activity...
  9. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ..4. Determine whether activation of sympathetic fibers terminating in dental pulp modulates neurosecretion from capsaicin-sensitive fibers...
  10. Neuroimaging of Purinergic Pathways in the Human ENS
    FEDIAS LEONTIOU CHRISTOFI; Fiscal Year: 2013
    ..human ENS/purinergic signaling, and establish purines as critical regulators of 5-HT release, neural activity, neurosecretion and mechanosensory reflexes;immune- neural activation and plasticity in IBD/IBS - providing a sound basis for ..
  11. Regulation of tomosyn-SNARE complex assembly in neurosecretion
    Edward L Stuenkel; Fiscal Year: 2010
    ....
  12. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2005
    ..Thus, we propose that astrocytes are capable of regulating the neurosecretion, neuronal connectivity and survival of GnRH and non-GnRH neurons and that these effects are primarily due to ..
  13. Pathophysiology of Mucus Hypersecretion in Asthma
    Christopher Evans; Fiscal Year: 2003
    ..neuron specific isoform) and the mutation of Drosophila MUNC18 ortholog ROP result in complete failures of neurosecretion and paralysis...
  14. LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDING
    Abhiram Sahu; Fiscal Year: 2001
    ..Peptide neurosecretion will be evaluated by assessing synthetic potential (mRNA), availability for release (peptide content), and ..
  15. Functional Reconstitution of Yeast Exocytosis
    James A McNew; Fiscal Year: 2010
    Membrane fusion is a fundamental process involved in diverse cellular events such as fertilization and neurosecretion. Biological membrane fusion relies on proteins to drive membrane merger and is likely facilitated by specific lipid ..
  16. Neuropeptide Y Regulation of Peripheral Human Nociceptors and Pain
    Kenneth Hargreaves; Fiscal Year: 2007
    ..unreadable] [unreadable] Specific Aim 2: Determine whether NPY inhibits neurosecretion of substance P from peripheral terminals of capsaicin-sensitive neurons innervating normal versus inflamed ..
  17. Beta Amyloid and Presynaptic Nicotinic Receptors
    Robert Nichols; Fiscal Year: 2007
    ..proposal are to characterize the effects of beta amyloid peptides on 1) nicotine-induced calcium responses and neurosecretion in individual nerve endings using confocal microscopy; 2) neurotransmitter release in vivo using microdialysis;..
  18. HORMONAL CONTROL OF HYPOTHALAMIC DOPAMINE SECRETION
    John Porter; Fiscal Year: 1992
    ..The findings of this study will provide insight into the mechanisms controlling neurosecretion by dopaminergic neurons of the brain...
  19. PROTEIN PHISPHORYLATION AND NEUROSECRETION
    Michael Browning; Fiscal Year: 1990
    The focus of this proposal will be on the role of protein phosphorylation in neurosecretion. Previous studies have shown that protein III (protein Illa, M/r III) and protein IIIb, M/r 74,000, and protein IIIb, M 55,000, are collectively ..
  20. MEMBRANE EXCITABILITY AND SECRETION FROM NERVE ENDINGS
    Meyer Jackson; Fiscal Year: 2007
    ..This provides a unique opportunity to investigate basic mechanisms underlying the regulation of neurosecretion. The present plan continues an investigation of membrane excitability in the posterior pituitary, emphasizing ..
  21. CAUDAL NEUROPEPTIDES--NVIRONMENTAL REGULATION
    David Pearson; Fiscal Year: 1990
    ..The proposed work is intended to define specific biochemical mechanisms that regulate the process of neurosecretion of that message into high molecular weight precursor, its processing into biologically active secretory ..
  22. BIOCHEMISTRY OF COATED VESICLES
    JAMES ROTHMAN; Fiscal Year: 2003
    ..underlying the compartmental organization of the cytoplasm and the pathways of exocrine, endocrine, and neurosecretion. Knowledge of the mechanism of action of gene products in these pathways, and their allelic variants, will ..
  23. HORMONAL REGULATION OF PRESYNAPTIC RELEASE MECHANISMS
    MARY WORDEN; Fiscal Year: 1999
    ..second 50 ms) following stimulation with the goal of separating hormonal effects on spontaneous and evoked neurosecretion. To address potential problems with access of the bath-applied test reagents to the release site, experiments ..
  24. MODULATION OF SECRETION IN CHROMAFFIN CELLS
    EDWARD WESTHEAD; Fiscal Year: 1991
    ..catecholamina-secreting cells abovine chromuffin cells) have become a widely used as models for the study of neurosecretion. Two aspects of this project are novel...
  25. ONTOGENY AND EXPRESSION OF THE CFTR IN BRAIN
    ANDREW MULBERG; Fiscal Year: 2003
    ..In children with cystic fibrosis (CF), alterations in puberty and fertility are well-described complications. Neurosecretion may be modulated by the cystic fibrosis transmembrane conductance regulator (CFTR), resulting in abnormal ..
  26. CONFERENCE ON PRESYNAPTIC RECEPTORS
    Stanley Kalsner; Fiscal Year: 1990
    ..ions, second messengers and other significant aspects linking receptor activation to alterations in neurosecretion. It is also expected that the second day will have voluntary contributions in the form of poster sessions, and ..
  27. Proton as co-transmitter of neuronal signaling
    Martin Morad; Fiscal Year: 2006
    ..To test this hypothesis under feasible experimental conditions, we will use two models of neurosecretion: 1) PC12 and chromaffin cells and 2) cultures of cortical and cerebellar neurons, where agonist and protons ..
  28. MEMBRANE EXCITABILITY AND SECRETION FROM NERVE ENDINGS
    Meyer Jackson; Fiscal Year: 2000
    ..Using reagents for CAPS and synaptotagmin, two proteins with demonstrated roles in neurosecretion, experiments will provide insight into how these proteins couple excitation and secretion in nerve endings...
  29. NEUROHORMONAL REGULATION OF CYTOCHROME SYNTHESIS
    LARRY KEELEY; Fiscal Year: 1980
    ..The research will isolate and structurally characterize the neurohormone and investigate the timing of neurosecretion. Studies will be performed on specific cytochromes to identify the action of the neurohormone on cytochrome ..
  30. HERRING BODY AND PITUICYTE IN NEUROSECRETION
    DIETER DELLMANN; Fiscal Year: 1980
    ..The regeneration of neurosecretory axons in the frog will be investigated in a correlative transmission and scanning electronmicroscopic study. ..
  31. MOLECULAR MECHANISMS OF QUANTAL SYNAPTIC TRANSMISSION
    John Hackett; Fiscal Year: 1992
    b>Neurosecretion of transmitter substance is a cellular process whereby information transfer occurs in the nervous system...
  32. VIII INTERNATIONAL SYMPOSIUM ON NEUROSECRETION
    DONALD FARNER; Fiscal Year: 1980
    The series of International Symposia on Neurosecretion began in 1953 at the Stazione Zoologica di Napoli, having been organized by the late Professor Ernst Scharrer and Professor Berta Scharrer who were then members of the faculty of the ..
  33. The Role of IL-1beta in Neurosecretory Function
    John Watt; Fiscal Year: 2002
    ..and vasopressin (VP) neurons of the rat magnocellular neurosecretory system (MNS) where it may act to modulate neurosecretion of OT and VP by influencing neuronal-glial interactions...
  34. SNARE HYPOTHESIS AT NERVE ENDINGS
    EDWARD STUENKEL; Fiscal Year: 2002
    ..Experiments proposed will test the hypothesis that nSec1 protein (nSec1p) regulates neurosecretion via a specific regulated interaction with syntaxins and that this interaction enhances secretory granule ..
  35. Functional changes in GnRH neurons with age
    MARY KUEHL KOVARIK; Fiscal Year: 2007
    ..Reproduction in mammals is critically dependent upon the appropriate neurosecretion of gonadotropin-releasing hormone (GnRH)...
  36. MECHANISMS OF PEPTIDE SECRETION IN PC12 CELLS
    ERIK SCHWEITZER; Fiscal Year: 1999
    ..Abstract) The long-term goal of this project is an understanding, at the molecular level, of the process of neurosecretion, which is responsible for the release of rapidly-acting neurotransmitters and longer-acting neuromodulators ..
  37. THE STRUCTURAL BASIS OF NEUROSECRETION
    John Heuser; Fiscal Year: 1980
    ....
  38. STRUCTURE/FUNCTION OF THE SNARE COMPLEX
    Phyllis Hanson; Fiscal Year: 2002
    ..this information we will be better able to understand how intracellular membrane fusion, and in particular neurosecretion, can be modulated or abolished and how such alterations contribute to human disease and could be exploited to ..
  39. Mechanisms of Fusion & Transmitter release
    Manfred Lindau; Fiscal Year: 2007
    ..This process of neurosecretion is of outstanding importance in a broad range of physiological functions in the human body...
  40. CELLULAR MECHANISMS OF NEUROENDOCRINE HORMONE SECRETION
    NANCY WAYNE; Fiscal Year: 2003
    ..Revealing mechanisms that control neurosecretion is vital to our understanding of both homeostasis of a wide variety of physiological systems and disease ..
  41. NOVEL PROTEINS IN NEUROTRANSMITTER RELEASE
    Lian Li; Fiscal Year: 2001
    ..synaptobrevin and the plasma membrane proteins syntaxin and SNAP-25 has been shown to be a critical step in neurosecretion. A major challenge now is to understand how the formation of this complex is regulated to achieve the temporal ..
  42. TROPHISM AND TRANSMITTER RELEASE IN SYMPATHETIC NEURONS
    ARUN WAKADE; Fiscal Year: 1993
    ..Four major aspects of neurosecretion will be covered in the proposed research plan. 1...
  43. The Role of Ceramide Kinase in Neurosecretion
    Sandra Bajjalieh; Fiscal Year: 2002
    ..This work will lay the foundation for biochemical and genetic studies of the role of ceramide kianse, its substrate and its product in neurotransmission and how changes in its activity contribute to synaptic plasticity. ..
  44. ELECTRICAL AND BIOCHEMICAL PROPERTIES OF EXCITABLE CELLS
    LORIN MULLINS; Fiscal Year: 1980
    ..The role of Ca in neurosecretion has been recognized for some time...
  45. Circadian Clock Regulation of Pulsatile GnRH Secretion
    PATRICK CHAPPELL; Fiscal Year: 2006
    ..regarding the nature of the GnRH "pulse generator," provide insight into broad mechanisms of endocrine neurosecretion, and allow for the candidate to fully develop into a principal investigator capable of eventually becoming a ..
  46. MECHANISMS OF INTRACELLULAR MEMBRANE FUSION
    JAMES ROTHMAN; Fiscal Year: 2004
    ..underlying the compartmental organization of the cytoplasm and the pathways of exocrine, endocrine, and neurosecretion. Knowledge of the mechanism of action of gene products in these pathways, and their allelic variants, will ..
  47. OPIOID EFFECTS ON HYPOTHALAMIC NEURONAL EXCITABILITY
    Martin Kelly; Fiscal Year: 2002
    ..the gonadal steroid 17 beta-estradiol (E2) modulates opioidergic (beta-endorphin) tone and subsequently the neurosecretion of hypothalamic peptides and amines and activation of reward pathways in the female...
  48. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  49. Mechanisms of HIF activation in pulmonary vasculature.
    Navdeep Chandel; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  50. STRESS BIOLOGY, RACE/ETHNICITY & INFECTION IN PREGNANCY
    Pathik Wadhwa; Fiscal Year: 2006
    ..g., the ex-vivo immune challenge methodology) to identify women who are at heightened risk for infection and infection-related preterm birth, thereby improving obstetric risk assessment. ..
  51. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  52. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  53. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..