- The PC12 cell as model for neurosecretion
R H S Westerink
Cellular and Molecular Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
Acta Physiol (Oxf) 192:273-85. 2008
..As PC12 cells have some advantages over other models for neurosecretion, including chromaffin cells, it is more than likely that in the following decade PC12 cells will continue to ..
- The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells
Jin Hua Tian
Synaptic Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
J Neurosci 25:10546-55. 2005
..SNARE)-based fusion machinery is critical for understanding the mechanisms underlying calcium-dependent neurosecretion. Snapin binds to synaptosomal-associated protein 25 kDa (SNAP-25) and enhances the association of the SNARE ..
- A two-step model of secretion control in neuroendocrine cells
Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
Pflugers Arch 424:105-12. 1993
..Given these functional dependences a variety of results from the literature can be simulated. In particular, the model predicts the occurrence of secretory depression and augmentation under appropriate conditions...
- A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion
Alexander M Walter
Department of Functional Genomics and Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam and VU University Medical Center, Amsterdam, The Netherlands Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
PLoS Comput Biol 9:e1003362. 2013
- Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion
Nobutoshi C Harata
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA
J Neurochem 97:1546-70. 2006
..Full-collapse fusion and kiss-and-run will each contribute to maintaining cellular communication over a wide range of frequencies...
- In PC12 cells, expression of neurosecretion and neurite outgrowth are governed by the transcription repressor REST/NRSF
Division of Neuroscience, IIT Network, Research Unit of Molecular Neuroscience, Vita Salute San Raffaele University and Scientific Institute San Raffaele, DIBIT, Via Olgettina 58, 20132 Milan, Italy
Cell Mol Neurobiol 30:1295-302. 2010
..addition to the wild-type, low REST neurosecretory cells, it includes spontaneously defective clones lacking neurosecretion, where REST is as high as in non-nerve cells...
- Munc18-1 as a key regulator of neurosecretion
Gayoung A Han
Division of Fundamental Neurobiology, University Health Network, Toronto, Ontario, Canada
J Neurochem 115:1-10. 2010
Munc18-1 plays essential roles in neurosecretion by interacting with syntaxin-1 and controlling the formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex...
- Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells
CNRS, Institut de Neurobiologie Alfred Fessard, Laboratoire de Neurobiologie Cellulaire et Moleculaire, Gif sur Yvette, France
PLoS ONE 3:e3448. 2008
..However, the mechanism through which slow Na+ influx promotes neurosecretion is not fully understood...
- Nicotinic acid adenine dinucleotide phosphate enhances quantal neurosecretion at the frog neuromuscular junction: possible action on synaptic vesicles in the releasable pool
Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614-1708, USA
Mol Pharmacol 60:718-24. 2001
..1,4,5-trisphosphate (IP(3)) and cyclic adenosine diphosphate-ribose (cADPR) are second messengers that enhance neurosecretion by inducing Ca(2+) release from smooth endoplasmic reticulum (SER)...
- Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans
Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 24:3115-24. 2004
..in the mouse results in reduced insulin release and additional phenotypes, consistent with a general effect on neurosecretion and hormone release...
- Localization of synaptic proteins involved in neurosecretion in different membrane microdomains
CNR Institute of Neuroscience, Department of Medical Pharmacology, University of Milan, Milan, Italy
J Neurochem 100:664-77. 2007
A number of proteins and signalling molecules modulate voltage-gated calcium channel activity and neurosecretion. As recent findings have indicated the presence of Ca(v)2...
- PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons
Ke Ming Zhou
Key Laboratory of Molecular Biophysics, Ministry of Education, and Joint Laboratory of Institute of Biophysics, Huazhong University of Science and Technology, Wuhan 430074, China
Neuron 56:657-69. 2007
..Interestingly, the defect in DCV docking caused by UNC-31 mutation can be fully rescued by PKA activation. We also demonstrate that UNC-31 is required for UNC-13-mediated augmentation of DCV exocytosis...
- Nitric oxide implication in the control of neurosecretion by chromaffin cells
M J Oset-Gasque
Instituto de Bioquimica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
J Neurochem 63:1693-700. 1994
..These results suggest that NO could be an important intracellular messenger in the regulation of neurosecretion in chromaffin cells.
- How important are Rho GTPases in neurosecretion?
CNRS UPR 3212, Institut des Neurosciences Cellulaires et Integratives, Universite de Strasbourg, Strasbourg, France
J Neurochem 117:623-31. 2011
..However, the role of Rho GTPases in neurosecretion is poorly documented...
- Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2
Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 5:e1000447. 2009
..To our knowledge, this is the first mutation identified that results in increased neurosecretion, a phenotype that has clinical implications for DCV-mediated secretory disorders.
- Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis
Frederic A Meunier
Lincoln s Inn Fields Laboratories, London Research Institute, Cancer Research UK, London WC2A 3PX, United Kingdom
Mol Biol Cell 16:4841-51. 2005
..Based on these results, we propose that production of PtdIns3P by PI3K-C2alpha is required for acquisition of fusion competence in neurosecretion.
- A neuroendocrine mechanism for sustaining fear
Department of Physiology and Biophysics, Georgetown University, Washington, DC 20007, USA
Trends Neurosci 28:629-35. 2005
..Central regulation of CRH by glucocorticoids is important for adaptive and sustained fear-related behaviors, and its aberration is associated with anxiety and depressive disorders...
- New insights on Saccus vasculosus evolution: a developmental and immunohistochemical study in elasmobranchs
Department of Cell Biology and Ecology, University of Santiago de Compostela, Santiago de Compostela, Spain
Brain Behav Evol 70:187-204. 2007
..The existence of saccopetal monoaminergic and neurosecretory fibers reveals reciprocal connections between the SV and hypothalamic structures which have not been previously detected in teleosts...
- Squeeze involvement in the specification of Drosophila leucokinergic neurons: Different regulatory mechanisms endow the same neuropeptide selection
Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Mech Dev 124:427-40. 2007
..Thus, Sqz appears to be a regulatory factor for neuropeptidergic identity common to all leucokinergic cells, whose function in different cell types is regulated by cell-specific factors...
- Interactions of temperature and angiotensin II in paraventricular neurons of rats in vitro
Institut fur Normale und Pathologische Physiologie, Deutschhausstrasse 2, 35037 Marburg, Germany
Pflugers Arch 444:117-25. 2002
- Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69012 Heidelberg, Germany
Cell 129:1389-400. 2007
- Exon expression profiling reveals stimulus-mediated exon use in neural cells
Adrienne E McKee
Department of Systems Biology, 200 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
Genome Biol 8:R159. 2007
..Although calcium-induced transcription and transcript variation have both been recognized as important sources of gene regulation, the interplay between these two phenomena has not been evaluated on a genome-wide scale...
- Synergistic activation of astrocytes by ATP and norepinephrine in the rat supraoptic nucleus
INSERM U710, University of Montpellier II, 34095 Montpellier Cedex 9, France
Neuroscience 148:712-23. 2007
- Synapsin II negatively regulates catecholamine release
Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Brain Cell Biol 35:125-36. 2006
- Beacon-like immunoreactivity in the hypothalamus of Sprague-Dawley rats
G Cristina Brailoiu
Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577 Johnson City, TN 37614, USA
Neurosci Lett 317:166-8. 2002
- The morphological and histochemical neurosecretory magnocellular system in the rat after administration of chlorpromazine
Department of Histology and Embryology, Medical University, Białystok, Poland
Folia Morphol (Warsz) 63:83-5. 2004
..It was found that CPZ reduced the content of the neurosecretory material after 24 h, while an increase was observed 7 days after the last drug administration...
- Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models
Department of Paediatric Laboratory Medicine and Programme in Structural Biology and Biochemistry, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Am J Respir Cell Mol Biol 27:553-60. 2002
..We propose that these tumor cell lines may be useful models for investigating the role of CFTR in PNEC/NEB functions in health and disease...
- Fish caudal neurosecretory system: a model for the study of neuroendocrine secretion
Catherine R McCrohan
Faculty of Life Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
Gen Comp Endocrinol 153:243-50. 2007
..Furthermore, the presence of homologues of urotensins throughout the vertebrates has sparked new interest in these peptides and their functional evolution...
- Mechanism of alpha-latrotoxin action at nerve endings of neurohypophysis
Department of Molecular and Integrative Physiology, 7807 Medical Sciences II Building, University of Michigan, Ann Arbor, MI 48109 0622, USA
Brain Res 992:30-42. 2003
..While alpha-latrotoxin mobilizes intracellular Ca(2+) stores the elevation in [Ca(2+)] reached is insufficient to trigger measurable exocytosis...
- Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23
Jakob B Sørensen
Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
Cell 114:75-86. 2003
..We conclude that three alternative SNARE components support exocytosis, but they differ in their ability to stabilize vesicles in the primed state...
- Neuroendocrine facets of human puberty
Johannes D Veldhuis
University of Virginia School of Medicine, Charlottesville, USA
Neurobiol Aging 24:S93-S119; discussion S121-2. 2003
..Most notably, the outflow of gonadotropins and growth hormone (GH) proceeds both independently and jointly. The current update highlights this unique dependency in the human...
- Regulation of cyclic adenosine 3',5'-monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing hormone neurons
Carlos E Navarro
Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Endocrinol 17:1792-804. 2003
..These findings indicate that occupancy of the plasma membrane-associated ERs expressed in GT1-7 neurons by physiological estradiol levels causes activation of a Gi protein and modulates cAMP signaling and neuropeptide secretion...
- Gonadotropin-releasing hormone (GnRH) receptor expression and membrane signaling in early embryonic GnRH neurons: role in pulsatile neurosecretion
Antonio J Martinez-Fuentes
Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
Mol Endocrinol 18:1808-17. 2004
- Neuroendocrine stress response in patients undergoing benign ovarian cyst surgery by laparoscopy, minilaparotomy, and laparotomy
Department of Anesthesiology, Intensive Care, and Emergency Medicine, Catholic University of the Sacred Heart, Largo Agostino Gemelli no 8, Rome, Italy
J Am Assoc Gynecol Laparosc 10:159-65. 2003
..To quantify and compare neuroendocrine stress responses during and immediately after surgery by laparoscopy, minilaparotomy, and laparotomy for benign ovarian cysts...
- The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype
Alexander W Bruce
Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
J Neurochem 98:1828-40. 2006
..This is the first demonstration of a transcription factor that directly controls expression of many major components of the RSP and provides further insight into the function of REST...
- Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells
Y Peng Loh
Section on Cellular Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
J Mol Neurosci 22:63-71. 2004
..These results support the model that POMC is actively sorted to the RSP granules for processing and secretion by a sorting signal-mediated mechanism...
- Calcium requirements for exocytosis do not delimit the releasable neuropeptide pool
Department of Pharmacology, E1351 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cell Calcium 33:267-71. 2003
- [Morphofunctional basis of neurosecretory cell plasticity]
P E Garlov
Institute of Cytology RAS, St Petersburg
Tsitologiia 44:747-67. 2002
- The polybasic sequence in the C2B domain of rabphilin is required for the vesicle docking step in PC12 cells
Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama, Japan
J Neurochem 100:770-9. 2007
..These results indicate that the polybasic sequence in the C2B domain functions as an effector domain for SNAP-25 and controls the number of 'releasable' vesicles docked to the plasma membrane...
- A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells
Department of Biochemistry, University of Cambridge, Cambridge, UK
J Neurochem 99:1435-44. 2006
..Hence, A35C may provide clues about the mechanisms that underlie control of neurosecretion. We used mRNA microarray profiling to examine gene expression in A35C...
- Postnatal development of catecholamine inputs to the paraventricular nucleus of the hypothalamus in rats
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Comp Neurol 438:411-22. 2001
- Extrasynaptic release of dopamine in a retinal neuron: activity dependence and transmitter modulation
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Neuron 30:211-25. 2001
..Since the somatic receptors for these ligands are extrasynaptic, we suggest that the composition of the extracellular fluid directly modulates extrasynaptic release...
- Neuroendocrine secretory protein 55 (NESP55) in the spinal cord of rat: an immunocytochemical study
Department of Anatomy and Cell Biology, Institute of Biomedicine, Goteborg University, SE 405 30 Goteborg, Sweden
J Comp Neurol 506:733-44. 2008
- Butyrate sensitizes the release of substance P and calcitonin gene-related peptide evoked by capsaicin from primary cultured rat dorsal root ganglion neurons
Department of Anatomy, Shandong University School of Medicine, Jinan 250012, China
Neuro Endocrinol Lett 27:695-701. 2006
..To investigate whether butyrate increases substance P (SP) and calcitonin gene-related peptide (CGRP) release evoked by capsaicin from primary cultured dorsal root ganglion (DRG) neurons...
- Plasticity of nonapeptidergic neurosecretory cells in fish hypothalamus and neurohypophysis
Pavel Evgenyevich Garlov
Institute of Cytology, Russian Academy of Science, St Petersburg 194064, Russia
Int Rev Cytol 245:123-70. 2005
..In the latter, the key role is probably played by the Golgi complex...
- Circadian regulation of the lark RNA-binding protein within identifiable neurosecretory cells
Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
J Neurobiol 45:14-29. 2000
- Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion
European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA CNRS, University of Rouen 76821 Mont St Aignan, France
FASEB J 22:1756-68. 2008
..These findings demonstrate the implication of a selenoprotein in the regulation of Ca(2+) homeostasis and neuroendocrine secretion in response to a cAMP-stimulating trophic factor...
- Expression of the neurosecretory process in PC12 cells is governed by REST
Vita Salute San Raffaele University, Center of Excellence in Cell Development, Milan, Italy
J Neurochem 105:1369-83. 2008
..Our results identify REST, working by direct and indirect mechanisms, as the factor governing the maintenance of the neurosecretory process and the properties of dense-core vesicles in PC12 cells...
- Contributions of insect research toward our understanding of neurosecretion
Marc J Klowden
Division of Entomology, University of Idaho, Moscow 83844, USA
Arch Insect Biochem Physiol 53:101-14. 2003
The process of neurosecretion is an important and widespread method of biological communication among animals...
- Role of biogenic amines and cHH in the crustacean hyperglycemic stress response
BRAIN Center, Department of Biology, University of Trieste, via Giorgieri 7, I 34127 Trieste, Italy
J Exp Biol 208:3341-7. 2005
..The fact that copper induced a rapid and massive release of 5-HT from the eyestalk can explain its demonstrated role in inducing the release of cHH and the consequent hyperglycemia in intact but not eyestalkless animals...
- Secrets of the secretory pathway in dendrite growth
Michael D Ehlers
Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 55:686-9. 2007
..Dendrites and axons exhibit different morphologies and patterns of growth. This difference in neuronal structure is controlled by evolutionarily conserved directed trafficking through the secretory pathway...
- Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion
Department of Physiology, Uppsala University, Uppsala, Sweden
J Clin Invest 108:625-33. 2001
..Thus, melatonin stimulates duodenal bicarbonate secretion via action at enterocyte MT2-receptors and mediates neural stimulation of the secretion...
- Synthesis of the porcine LH- and FSH-releasing hormone by the solid-phase method
Biochem Biophys Res Commun 45:822-7. 1971
- The destination of the aged, nonreleasable neurohypophyseal peptides stored in the neural lobe is associated to the remodeling of the neurosecretory axon
Instituto de Histologia y Patologia, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile
Microsc Res Tech 68:347-59. 2005
..No differences were detected at the neural lobe level between normal and mutant rats subjected to the same experimental conditions...
- The pharmacological treatment of heart failure: are we looking at the sunset of the neurohormonal hypothesis
Ital Heart J 3:437-8. 2002
- Calmodulin increases transmitter release by mobilizing quanta at the frog motor nerve terminal
Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, TN 37614 1708, USA
Br J Pharmacol 137:719-27. 2002
..The decreases in MEPP size and m produced by W7 were both reversed by addition of CaM. Our results suggest that CaM increases transmitter release by mobilizing synaptic vesicles at the frog motor nerve terminal...
- Clinical and molecular evidence of abnormal processing and trafficking of the vasopressin preprohormone in a large kindred with familial neurohypophyseal diabetes insipidus due to a signal peptide mutation
Department of Pediatrics, Aarhus University Hospital
J Clin Endocrinol Metab 84:2933-41. 1999
..diabetes insipidus (adFNDI) is a rare disease characterized by postnatal onset of polyuria and a deficient neurosecretion of the antidiuretic hormone, arginine vasopressin (AVP)...
- Effects of reducing agents on glutathione metabolism and the function of carotid body chemoreceptor cells
Departamento de Bioquimica y Biologia Molecular y Fisiologia, Facultad de Medicina, Universidad de Valladolid, E 47005 Valladolid, Spain
Biol Chem 385:265-74. 2004
..found that hypoxia does not alter the glutathione reduction potential but that it activates chemoreceptor cell neurosecretion. Incubation of tissues with reduced glutathione increases the glutathione-reducing potential but does not ..
- New concepts of the neuroendocrine regulation of gonadotropin surges in rats
J E Levine
Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
Biol Reprod 56:293-302. 1997
..that ovulate spontaneously, two key events mediate the stimulation of preovulatory gonadotropin surges: 1) neurosecretion of a preovulatory LHRH surge and 2) an acute increase in responsiveness of the pituitary gland to the LHRH ..
- Experimental uremia affects hypothalamic amino acid neurotransmitter milieu
Division of Paediatric Nephrology, University Children s Hospital, University of Heidelberg, Heidelberg, Germany
J Am Soc Nephrol 12:1218-27. 2001
..The mechanisms of neurosecretion were evaluated further by inhibition of vesicular release with the use of Ca(2+)-free, Mg(2+)-enriched ..
- Pulsatile release of luteinizing hormone-releasing hormone (LHRH) in cultured LHRH neurons derived from the embryonic olfactory placode of the rhesus monkey
Wisconsin Regional Primate Research Center, and Department of Pediatrics, University of Wisconsin, Madison 53715 1299, USA
Endocrinology 140:1432-41. 1999
..These results indicate that: 1) the presence of extracellular Ca2+ is essential for LHRH neurosecretion; 2) Ca2+ enters the cell via L-type channels but not N-type channels; and 3) mobilization of intracellular Ca2+..
- A two-cell biosensor that couples neuronal cells to optically monitored fish chromatophores
R R Preston
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
Biosens Bioelectron 16:447-55. 2001
..Agents known to stimulate catecholamine neurosecretion (secretagogues) were presented to the PC12 cells...
- Translating blood-borne stimuli: chemotransduction in the carotid body
Department of Physiology, The Medical School, University of Birmingham, Birmingham, UK
Sheng Li Xue Bao 59:128-32. 2007
..and the resultant membrane depolarisation is sufficient to activate voltage-gated Ca(2+) entry leading to neurosecretion and afferent discharge...
- Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings
Jody K Hirsh
Department of Molecular Pharmacology and Biological Chemistry S 215, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
J Physiol 545:337-43. 2002
..GTP-binding protein attached to synaptic vesicles, has been implicated in several stages in the process of neurosecretion, including a late stage occurring just prior to the actual release of neurotransmitter...
- The Coffin-Lowry syndrome-associated protein RSK2 and neurosecretion
Département Neurotransmission and Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Intégratives UPR 3212, Centre National de Recherche Scientifique and Université de Strasbourg, 5 rue Blaise Pascal, 67084 Strasbourg, France
Cell Mol Neurobiol 30:1401-6. 2010
..no obvious brain abnormalities at the anatomical and histological levels to study the function of RSK2 in neurosecretion. Behavioral studies revealed normal motor coordination, but a profound retardation in spatial learning and a ..
- The multiple actions of black widow spider toxins and their selective use in neurosecretion studies
Y A Ushkaryov
Department of Biological Sciences, Imperial College, London, SW7 2AY, UK
Toxicon 43:527-42. 2004
..As a result, important insights have been gained into the receptor signalling and the role of intracellular Ca(2+) stores in the effect of alphaLTX...
- Effect of CO on VO2 of carotid body and chemoreception with and without Ca2+
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Auton Nerv Syst 66:1-6. 1997
..Lahiri, News Physiol. Sci. 9 (1992) 161-165], Ca2+ effects occur at the level of neurosecretion after the level of oxygen consumption, according to the following scheme: CO-hypoxia-->VO2 decrease-->K+ ..
- Flufenamic acid modulates multiple currents in gonadotropin-releasing hormone neurons
Department of Biological Engineering, University of Missouri, Dalton Cardiovascular Research Center, Columbia, MO 65211, USA
Brain Res 1353:94-105. 2010
Reproduction in mammals is dependent upon the appropriate neurosecretion of gonadotropin-releasing hormone (GnRH), yet the endogenous generation of activity underlying GnRH secretion remains poorly understood...
- Clinically non-functioning pituitary macroadenomas in the elderly
Patrizia Del Monte
Division of Endocrinology, Galliera Hospital, Mura delle Cappuccine 14, 16128 Genova, Italy
Aging Clin Exp Res 19:34-40. 2007
..The aim of the present study was to evaluate the clinical presentation, characteristics and post-surgical outcome of non-functioning pituitary macroadenomas (NFPM) in elderly patients...
- N type Ca2+ channels and RIM scaffold protein covary at the presynaptic transmitter release face but are components of independent protein complexes
Cellular and Molecular Biology Division, MP14 320 Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario, M5T 2S8 Canada
Neuroscience 140:1201-8. 2006
..2) calcium channels. Thus, neurosecretion involves two key processes: the docking of vesicles at the transmitter release site, a process that involves ..
- Substance P enhances desensitization of the nicotinic response in bovine chromaffin cells but enhances secretion upon removal
L K Lyford
Program in Molecular and Cellular Biology, University of Massachusetts, Amherst 01003
J Neurochem 55:1960-5. 1990
A fundamental process in neurosecretion is desensitization, or a declining response to a stimulus. The response of chromaffin cells to continuous nicotinic stimulation, secretion of catecholamines, desensitizes within a few minutes...
- Regulation of hypothalamic gonadotropin-releasing hormone secretion in experimental uremia: in vitro studies
Department of Obstetrics and Gynecology, University of Sydney, Australia
Neuroendocrinology 54:353-8. 1991
..GnRH release and the function of GnRH-secreting neurons have suggested functional disturbances of GnRH neurosecretion; however, the precise biochemical mechanisms involved were not defined...
- Intracellular interaction between syntaxin and Munc 18-1 revealed by fluorescence resonance energy transfer
Department of Immunology and Molecular Biology, Veterinary Faculty, Free University, Berlin
Mol Membr Biol 22:401-10. 2005
b>Neurosecretion is catalyzed by assembly of a soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE)-complex composed of SNAP-25, synaptobrevin and syntaxin. Munc 18-1 is known to bind to syntaxin in vitro...
- Clocks and the black box: circadian influences on gonadotropin-releasing hormone secretion
P E Chappell
Department of Reproductive Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0674, USA
J Neuroendocrinol 17:119-30. 2005
..This review re-examines multiple models of circadian control of reproductive neurosecretion, armed with the recent characterisation of the intracellular transcriptional feedback loops that comprise the ..
- Suppression of Ca2+ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells
Jason J Lefkowitz
Department of Physiology, University of Massachusetts Medical School, Worcester, 01655, USA
J Gen Physiol 134:267-80. 2009
A central concept in the physiology of neurosecretion is that a rise in cytosolic [Ca(2+)] in the vicinity of plasmalemmal Ca(2+) channels due to Ca(2+) influx elicits exocytosis...
- Oxytocin neuron activation in NCAM-deficient mice: anatomical and functional consequences
D T Theodosis
Laboratory of Morphofunctional Neurobiology, INSERM U 378, University Victor Segalen, 733770 Bordeaux, France
Eur J Neurosci 20:3270-80. 2004
During stimulated neurosecretion in the rat, oxytocin neurons display a reduced glial coverage and receive an increased number of synapses, changes that are reversed on arrest of stimulation...
- Blockade of growth hormone-releasing factor (GRF) activity in the pituitary and hypothalamus of the conscious rat with a peptidic GRF antagonist
M D Lumpkin
Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, D C 20007
Endocrinology 124:1522-31. 1989
..possibly representing a negative ultrashort loop autoregulation of GRF and/or stimulation of somatostatin neurosecretion. To demonstrate that such neuromodulation acts physiologically through endogenous GRF activity, the peptidic ..
- The proteins of synaptic vesicle membranes are affected during ageing of rat brain
S R Lee
Department of Biochemistry, College of Medicine, Hallym University, Chunchon, Kangwon Do, Korea
Exp Mol Med 33:220-5. 2001
..In this study, we have examined the regulation of small GTP-binding proteins that are implicated in neurosecretion and differentiation of neuron during ageing processes...
- "Low" concentrations of sodium fluoride inhibit neurotransmitter release from the guinea-pig superior cervical ganglion
Pier Giorgio Borasio
Department of Biology, Section of General Physiology, University of Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
Neurosci Lett 364:86-9. 2004
..Thus a NaF-sensitive G protein, linked to cAMP synthesis, is determinant for the inhibition of neurosecretion in this cholinergic synapse, involving Ca2+-dependent mechanisms.
- Expression of dense-core vesicles and of their exocytosis are governed by the repressive transcription factor NRSF/REST
Vita Salute San Raffaele University, Milan, Italy
Ann N Y Acad Sci 1152:194-200. 2009
..In wild-type PC12 fully competent for neurosecretion, NRSF/REST is low...
- Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release
Department of Biochemistry, Imperial College, London, UK
Biochemistry 35:2630-6. 1996
The seven types (A--G) of botulinum neurotoxin (BoNT) are Zn2+ -dependent endoproteases that potently block neurosecretion. Syntaxin is presently thought to be the sole substrate for BoNT/C1, and synaptosomal-associated protein of Mr = 25 ..
- Purinergic signalling: past, present and future
Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
Braz J Med Biol Res 42:3-8. 2009
..Both short-term purinergic signalling in neurotransmission, neuromodulation and neurosecretion and long-term (trophic) purinergic signalling of cell proliferation, differentiation, motility, death in ..
- A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan
Brian H Lee
Department of Physiology, University of California San Francisco, San Francisco, CA, USA
PLoS Genet 4:e1000213. 2008
- Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells
Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
J Immunol 171:5320-7. 2003
..This protein has been implicated in the control of neurosecretion from dense core granules in neuronal cells as well as in the control of constitutive secretory pathways in ..
- alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor
V G Krasnoperov
Department of Environmental Medicine, New York University Medical Center, New York 10016, USA
Neuron 18:925-37. 1997
alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors...
- Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells
Experimental Diabetology and the Department of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, 01307 Dresden, Germany
J Biol Chem 278:26166-73. 2003
..Involvement of ICA69 in neurosecretion has been suggested by the impairment of acetylcholine release at neuromuscular junctions upon mutation of its ..
- Synaptobrevin 2 is palmitoylated in synaptic vesicles prepared from adult, but not from embryonic brain
Department of Immunology and Molecular Biology, Free University, Berlin, Germany
Mol Cell Neurosci 15:408-16. 2000
Neuronal SNARE-proteins such as synaptobrevin, SNAP 25, and synaptotagmin are key players during neurosecretion. So far palmitoylation of SNAP-25 and synaptotagmin 1 have been described in vivo...
- Secretory vesicle rebound hyperacidification and increased quantal size resulting from prolonged methamphetamine exposure
Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Neurochem 107:1709-21. 2008
..on secretory vesicle pH, and amperometry and intracellular patch electrochemistry to observe the effects on neurosecretion and cytosolic catecholamines in cultured rat chromaffin cells...
- A review of the role of neurosecretion in the control of juvenile hormone synthesis: a tribute to Berta Scharrer
Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
Insect Biochem Mol Biol 30:653-62. 2000
..For the latter group, the neuropeptide regulators of the corpora allata have yet to be isolated. The families of neurosecretory regulators will continue to grow...
- Identifying the stress transcriptome in the adrenal medulla following acute and repeated immobilization
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
Ann N Y Acad Sci 1148:1-28. 2008
..Robust changes were also observed in transcripts related to growth factors, apoptosis, neurosecretion/neuropeptides, heat shock proteins, structural proteins, chemokines, cytokines, metabolism/lipid-metabolism, ..
- Neuronal Ca2+ sensor 1, the mammalian homologue of frequenin, is expressed in chromaffin and PC12 cells and regulates neurosecretion from dense-core granules
B W McFerran
The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
J Biol Chem 273:22768-72. 1998
..No effect of overexpression was seen on GH release because of Ca2+ in permeabilized cells suggesting that NCS-1 may have a regulatory but not direct role in neurosecretion.
- Presence of paraneuronal pseudobranchial neurosecretory system in the gill region of two air-breathing clupeids, Notopterus chitala and Notopterus notopterus
Department of Zoology, University of Allahabad, Allahabad 211002, U P, India
Respir Physiol Neurobiol 171:135-43. 2010
The pseudobranchial neurosecretory system (PNS) is a system of neurosecretion observed in certain groups of teleosts, which are air-breathing or known to tolerate low oxygen tension in the surrounding water...
- A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells
Division of Immunology, Transplantation Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
J Cell Sci 124:3174-86. 2011
..Upregulation of REST promoted proliferation and phenotypic changes, thus hindering neurosecretion. The new REST-TSC2-β-catenin signaling paradigm might have an important role in various aspects of neural ..
- [Modulating effect of anticonvulsive agents on Ca2+ dependent membrane fusion in cell-free model of neurosecretion]
I O Trykash
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv
Ukr Biokhim Zh 75:81-6. 2003
..Ethosuximide- and sodium valproat-provoked fusion of synaptic vesicles and plasma membranes of synaptosomes were suppressed by convulsant drugs pentylenetetrazol and picrotoxin...
- Behavioral evaluation of GH treatment in short statured children and adolescents: findings from a pilot study
H C Steinhausen
Department of Child and Adolescent Psychiatry, University of Zurich, Switzerland
J Endocrinol Invest 25:351-6. 2002
..The behavioral changes over time were independent of diagnostic category, gender, height velocity, puberty and age...
- SNAP-25 traffics to the plasma membrane by a syntaxin-independent mechanism
Stephanie S Loranger
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
J Biol Chem 277:34303-9. 2002
..targets efficiently to the plasma membrane in cells of neuronal origin but only partially in HeLa cells, a neurosecretion-incompetent line. This phenotype was not rescued when syntaxin 1A was co-expressed with SNAP-25...
- Adequate stimuli of the carotid body: more than an oxygen sensor?
Department of Physiology, The Medical School, University of Birmingham, Birmingham, UK
Respir Physiol Neurobiol 157:12-21. 2007
..process, albeit converging at the point of type I cell membrane depolarisation or Ca(2+) -dependent neurosecretion. We suggest, therefore, that the carotid body might better be viewed as a polymodal receptor with its multiple ..
- Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta
Anja van de Stolpe
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Mol Endocrinol 18:2908-23. 2004
- Storage and secretion of beta-NAD, ATP and dopamine in NGF-differentiated rat pheochromocytoma PC12 cells
Ilia A Yamboliev
Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
Eur J Neurosci 30:756-68. 2009
..Adrenal chromaffin cells are thus used here as a single-cell model to examine mechanisms of concomitant neurosecretion. Using high-performance liquid chromatography techniques with electrochemical and fluorescence detection we ..
- Fusion of synaptic vesicles and plasma membrane in the presence of synaptosomal soluble proteins
I O Trikash
Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Leontovich st 9, 01601 Kiev, Ukraine
Neurochem Int 49:270-5. 2006
..between synaptic vesicles and plasma membranes isolated from rat brain synaptosomes is regarded as a model of neurosecretion. The main aim of current study is to investigate whether the synaptosomal soluble proteins are essential ..
- Oxygen sensing in neuroepithelial and adrenal chromaffin cells
C A Nurse
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
Novartis Found Symp 272:106-14; discussion 114-8, 131-40. 2006
..membrane-bound NADPH oxidase which during hypoxia, signals K+ channel inhibition, membrane depolarization and neurosecretion via changes in reactive oxygen species (ROS) (e.g. H2O2)...